CLAIMS
What is claimed is:
1. A particle comprising: (i) a core comprising a first active agent; and (ii) a first coating layer comprising a lipid at least partially covering the core.
2. A particle comprising: (i) a core comprising a first active agent; and (ii) a first coating layer comprising a carbohydrate at least partially covering the core.
3. A particle comprising: (i) a core comprising a first active agent; and (ii) a first coating layer comprising a protein at least partially covering the core.
4. A particle comprising: (i) a core comprising a first active agent; and (ii) a first coating layer comprising a cationic molecule at least partially covering the core.
5. A particle comprising: (i) a core comprising a first active agent; and (ii) a first coating layer comprising at least two molecules selected from lipids, carbohydrates, proteins, and cationic molecules and the coating layer at least partially covering the core.
6. The particle of any of claims 1-5, wherein the core further comprises a lipid, a carbohydrate, a protein, a cationic molecule, or any combinations thereof.
7. A particle comprising: (i) a core comprising a lipid, a carbohydrate, a protein, a cationic molecule, or any combinations thereof; (ii) and a first coating comprising a first active agent at least partially covering the core.
8. The particle of any of claims 1-7, wherein the coating acts a food for a pathogen.
9. The particle of any of claims 1-7, wherein the coating enhances targeting, binding, or retention of the active agent to a desired site of action.
10. The particle of any of claims 1-7, wherein the coating has a synergistic effect on activity of the active agent.
11. The particle of any of claims 1-7, wherein the coating acts as an active agent.
12. The particle of any of claims 1-7 wherein the particle further comprises a second active agent.
13. The particle of claim 12, wherein the second active agent is present in the core.
14. The particle of claim 12, wherein the second active agent is in the coating layer.

15. The particle of claim 12, wherein the second active agent forms a second coating layer on the first coating layer.
16. The particle of claim 15, wherein the particle further comprises a third coating layer on the second coating layer.
17. The particle of claim 16, wherein the third layer comprises a lipid, a protein, a polymer, a carbohydrate, or any combinations thereof.
18. The particle of any of claims 1-7, wherein the particle further comprises at least one second layer on the first coating layer.
19. The particle of claim 18, wherein the second layer comprises a lipid, a protein, a polymer, a carbohydrate, or any combinations thereof.
20. The particle of any of claims 1-19, wherein the particle further comprises at least two alternating coating layers, wherein one layer in the alternating coating layers comprises an active agent and another layer in the alternating coating layers comprises a lipid, a protein, a polymer, a carbohydrate, or any combinations thereof.
21. The particle of claim 20, wherein the outermost layer comprises the active agent.
22. The particle of claim 20, wherein the outermost layer comprises the lipid, the protein, the polymer, the carbohydrate, or any combinations thereof.
23. The particle of any of claims 1-22, wherein the active agent is selected from the group consisting of small organic or inorganic molecules, saccharines, oligosaccharides, polysaccharides, peptides; proteins, peptide analogs and derivatives, peptidomimetics, nucleic acids, nucleic acid analogs and derivatives, antibodies, antigen binding fragments of antibodies, lipids, extracts made from biological materials, naturally occurring or synthetic compositions, and any combinations thereof.
24. The particle of claim 23, wherein the active agent is selected from the group consisting of antifungal agents, antibacterial agents, antimicrobial agents, antioxidant agents, cooling agents, soothing agents, wound healing agents, anti-inflammatory-agents, anti-aging agents, anti-wrinkle agents, skin whitening or bleaching agents, ultraviolet (UV) light absorbing or scattering agents, skin depigmentation agents, dyes or coloring agents, deodorizing agents, fragrances, and any combinations thereof.

25. The particle of claim 24, wherein the active agent is selected from the group
consisting of pyrithione salts; ketoconazole; salicylic acid; curcumin or a derivative of curcumin, curcuminoids; tetrahydro curcuminoids; titanium dioxide (Ti02); zinc oxide (ZnO); chloroxylenol; flvanoids; CoQIO; vitamin C; herbal extracts; alkaloids; 13-cis retinoic acid; 3,4-methylenedioxymethamphetamine; 5-fluorouracil; 6,8-dimercaptooctanoic acid (dihydrolipoic acid); abacavir; acebutolol; acetaminophen; acetaminosalol; acetazolamide; acetohydroxamic acid; acetylsalicylic acid; acitretin; aclovate; acrivastine; actiq; acyclovir; adapalene; adefovir dipivoxil; adenosine; Albaconazole; albuterol; alfuzosin; Allicin; allopurinol; alloxanthine; allylamines; almotriptan; alpha-hydroxy acids; alprazolam; alprenolol; aluminum acetate; aluminum chloride; aluminum chlorohydroxide; aluminum hydroxide; amantadine; amiloride; aminacrine; aminobenzoic acid (PABA); aminocaproic acid; aminoglycosides such as streptomycin, neomycin, kanamycin, paromycin, gentamicin, tobramycin, amikacin, netilmicin, spectinomycin, sisomicin, dibekalin and isepamicin; aminosalicylic acid; amiodarone; amitriptyline; amlodipine; amocarzine; amodiaquin; Amorolfin; amoxapine; amphetamine; amphotericin B; ampicillin; anagrelide; anastrozole; Anidulafungin; anthralin; antibacterial sulfonamides and antibacterial sulphanilamides, including para-aminobenzoic acid, sulfadiazine, sulfisoxazole, sulfamethoxazole and sulfathalidine; antifungal peptide and derivatives and analogs thereof; apomorphine; aprepitant; arbutin; aripiprazole; ascorbic acid; ascorbyl palmitate; atazanavir; atenolol; atomoxetine; atropine; azathioprine; azelaic acid; azelaic acid; azelastine; azithromycin; bacitracin; bacitracin; beanomicins; beclomefhasone dipropionate; bemegride; benazepril; bendroflumethiazide; benzocaine; Benzoic acid with a keratolytic agent; benzonatate; benzophenone; benztropine; bepridil; beta-hydroxy acids; beta-lactams including penicillin, cephalosporin, and carbapenems such as carbapenem, imipenem, and meropenem; betamethasone dipropionate; betamethasone valerate; brimonidine; brompheniramine; bupivacaine; buprenorphine; bupropion; burimamide; butenafine; Butenafine; butoconazole; Butoconazole; cabergoline; caffeic acid; caffeine; calcipotriene; camphor; Cancidas; candesartan cilexetil; capsaicin;

carbamazepine; Caspofungin; cefditoren pivoxil; cefepime; cefpodoxime
proxetil; celecoxib; cetirizine; cevimeline; chitosan; chlordiazepoxide;
chlorhexidine; chloroquine; chlorothiazide; chloroxylenol;
chlorpheniramine; chlorpromazine; chlorpropamide; ciclopirox; Ciclopirox (ciclopirox olamine); cilostazol; cimetidine; cinacalcet; ciprofloxacin; citalopram; citric acid; Citronella oil; cladribine; clarithromycin; clemastine; clindamycin; clioquinol; clobetasol propionate; clomiphene; clonidine; clopidogrel; Clortrimazole; clotrimazole; Clotrimazole; clozapine; cocaine; Coconut oil; codeine; colistin; colymycin; cromolyn; crotamiton; Crystal violet; cyclizine; cyclobenzaprine; cycloserine; cytarabine; dacarbazine; dalfopristin; dapsone; daptomycin; daunorubicin; deferoxamine; dehydroepiandrosterone; delavirdine; desipramine; desloratadine; desmopressin; desoximetasone; dexamethasone; dexmedetomidine; dexmethylphenidate; dexrazoxane; dextroamphetamine; diazepam; dicyclomine; didanosine; dihydrocodeine; dihydromorphine; diltiazem; diphenhydramine; diphenoxylate; dipyridamole; disopyramide; dobutamine; dofetilide; dolasetron; donepezil; dopa esters; dopamine; dopamnide; dorzolamide; doxepin; doxorubicin; doxycycline; doxylamine; doxypin; duloxetine; dyclonine; echinocandins; econazole; Econazole; eflormthine; eletriptan; emtricitabine; enalapril; ephedrine; epinephrine; epinine; epirubicin; eptifibatide; ergotarnine; erythromycin; escitalopram; esmolol; esomeprazole; estazolam; estradiol; ethacrynic acid; ethinyl estradiol; etidocaine; etomidate; famciclovir; famotidine; felodipine; fentanyl; Fenticonazole; ferulic acid; fexofenadine; flecainide; fluconazole; Fluconazole; flucytosiine; Flucytosine or 5-fluorocytosine; fluocinolone acetonide; fluocinonide; fluoxetine; fluphenazine; flurazepam; fluvoxamine; formoterol; furosemide; galactarolactone; galactonic acid; galactonolactone; galactose; galantamine; gatifloxacin; gefitinib; gemcitabine; gemifloxacin; gluconic acid; glycolic acid; glycolic acid; glycopeptides such as vancomycin and teicoplanin; griseofulvin; Griseofulvin; guaifenesin; guanethidine; haloperidol; haloprogin; Haloprogin; herbal extract, an alkaloid, a flvanoid, Abafungin; hexylresorcinol; homatropine; homosalate; hydralazine; hydrochlorothiazide; hydrocortisone; hydrocortisone 17-butyrate; hydrocortisone 17-valerate; hydrocortisone 21-acetate;

hydromorphone; hydroquinone; hydroquinone monoether; hydroxyzine; hyoscyamine; hypoxanthine; ibuprofen; ichthammol; idarubicin; imatinib; imipramine; imiquimod; indinavir; indomethacin; Iodine; irbesartan; irinotecan; Isavuconazole; Isoconazole; isoetharine; isoproterenol; itraconazole; Itraconazole; kanamycin; ketamine; ketanserin; ketoconazole; ketoprofen; ketotifen; kojic acid; labetalol; lactic acid; lactobionic acid; lactobionic acid; lamivudine; lamotrigine; lansoprazole; lemon myrtle; letrozole; leuprolide; levalbuterol; levofloxacin; lidocaine; lincosamides such as lincomycin and clindamycin; linezolid; lobeline; loperamide; losartan; loxapine; lucensomycin; lysergic diethylamide; macrolides or ketolides such as erythromycin, azithromycin, clarithromycin, and telithromycin; mafenide; malic acid; maltobionic acid; mandelic acid; mandelic acid; maprotiline; mebendazole; mecamylamine; meclizine; meclocycline; memantine; menthol; meperidine; mepivacaine; mercaptopurine; mescaline; metanephrine; metaproterenol; metaraminol; metformin; methadone; methamphetamine; methotrexate; methoxamine; methyl nicotinate; methyl salicylate; methyldopa esters; methyldopamide; methyllactic acid; methylphenidate; metiamide; metolazone; metoprolol; metronidazole; mexiletine; Micafungin; miconazole; Miconazole; midazolam; midodrine; miglustat; minocycline; minoxidil; mirtazapine; mitoxantrone; moexiprilat; molindone; monobenzone; monolactams such as penicillin G, penicillin V, methicillin, oxacillin, cloxacillin, dicloxacillin, nafcillin, ampicillin, amoxicillin, carbenicillin, ticarcillin, meziocillin, piperacillin, azlocillin, temocillin, cepalothin, cephapirin, cephradine, cephaloridine, cefazolin, cefamandole, cefuroxime, cephalexin, cefprozil, cefaclor, loracarbef, cefoxitin, cefmetazole, cefotaxime, ceftizoxime, ceftriaxone, cefoperazone, ceftazidime, cefixime, cefpodoxime, ceftibuten, cefdinir, cefpirome, cefepime, and astreonam; morphine; moxifloxacin; moxonidine; mupirocin; nadolol; naftifine; Naftifine; nalbuphine; nalmefene; naloxone; naproxen; natamycin; Neem Seed Oil; nefazodone; nelfinavir; neomycin; nevirapine; N-guanylhistamine; nicardipine; nicotine; nifedipine; nikkomycins; nimodipine; nisoldipine; nizatidine; norepinephrine; nystatin; nystatin; octopamine; octreotide; octyl methoxycinnamate; octyl salicylate; ofloxacin; olanzapine; Olive leaf

extract; olmesartan medoxomil; olopatadine; omeprazole; Omoconazole;
ondansetron; Orange oil; oxazolidinones such as linezolid; oxiconazole;
Oxiconazole; oxotremorine; oxybenzone; oxybutynin; oxycodone;
oxymetazoline; padimate O; palmarosa oil; palonosetron; pantothenic acid;
pantoyl lactone; paroxetine; patchouli; pemoline; penciclovir; penicillamine;
penicillins; pentazocine; pentobarbital; pentostatin; pentoxifylline;
pergolide; perindopril; permethrin; phencyclidine; phenelzine; pheniramine;
phenmetrazine; phenobarbital; phenol; phenoxybenzamine;
phenpropimorph; phentolamine; phenylephrine; phenylpropanolamine; phenytoin; phosphonomycin; physostigmine; pilocarpine; pimozide; pindolol; pioglitazone; pipamazine; piperonyl butoxide; pirenzepine; Piroctone; piroctone olamine; podofilox; podophyllin; Polygodial; polyhydroxy acids; polymyxin; Posaconazole; pradimicins; pramoxine; pratipexole; prazosin; prednisone; prenalterol; prilocaine; procainamide; procaine; procarbazine; promazine; promethazine; promethazine propionate; propafenone; propoxyphene; propranolol; propylthiouracil; protriptyline; pseudoephedrine; pyrethrin; pyrilamine; pyrimethamine; quetiapine; quinapril; quinethazone; quinidine; quinolones such as nalidixic acid, oxolinic acid, norfloxacin, pefloxacin, enoxacin, ofloxacin, levofloxacin, ciprofloxacin, temafloxacin, lomefloxacin, fleroxacin, grepafloxacin, sparfloxacin, trovafloxacin, clinafloxacin, gatifloxacin, moxifloxacin, sitafloxacin, besifloxacin, besifloxaxin, clintafloxacin, ganefloxacin, gemifloxacin and pazufloxacin; quinupristin; rabeprazole; Ravuconazole; reserpine; resorcinol; retinal; retinoic acid; retinol; retinyl acetate; retinyl palmitate; ribavirin; ribonic acid; ribonolactone; rifampin; rifamycins such as rifampicin (also called rifampin), rifapentine, rifabutin, bezoxazinorifamycin and rifaximin; rifapentine; rifaximin; riluzole; rimantadine; risedronic acid; risperidone; ritodrine; rivasfigmine; rizatriptan; ropinirole; ropivacaine; salicylamide; salicylic acid; salicylic acid; salmeterol; scopolamine; selegiline; Selenium; selenium sulfide; serotonin; Sertaconazole; sertindole; sertraline; sibutramine; sildenafil; sordarins; sotalol; streptogramins such as quinupristin and daflopristin; streptomycin; strychnine; sulconazole; Sulconazole; sulfabenz; sulfabenzamide; sulfabromomethazine; sulfacetamide; sulfachlorpyridazine; sulfacytine;

sulfadiazine; sulfadimethoxine; sulfadoxine; sulfaguanole; sulfalene; sulfamethizole; sulfamethoxazole; sulfanilamide; sulfapyrazine; sulfapyridine; sulfasalazine; sulfasomizole; sulfathiazole; sulfisoxazole; tadalafil; tamsulosin; tartaric acid; tazarotene; Tea tree oil - ISO 4730 ("Oil of Melaleuca, Terpinen-4-ol type"); tegaserol; telithromycin; telmisartan; temozolomide; tenofovir disoproxil; terazosin; terbinafine; Terbinafine; terbutaline; terconazole; Terconazole; terfenadine; tetracaine; tetracycline; tetracyclines such as tetracycline, chlortetracycline, demeclocycline, minocycline, oxytetracycline, methacycline, doxycycline; tetrahydrozoline; theobromine; theophylline; thiabendazole; thioridazine; thiothixene; thymol; tiagabine; timolol; tinidazole; tioconazole; Tioconazole; tirofiban; tizanidine; tobramycin; tocainide; tolazoline; tolbutamide; tolnaftate; Tolnaftate; tolterodine; tramadol; tranylcypromine; trazodone; triamcinolone acetonide; triamcinolone diacetate; triamcinolone hexacetonide; triamterene; triazolam; triclosan; triclosan; Triclosan; triflupromazine; trimethoprim; trimethoprim; trimipramine; tripelennamine; triprolidine; tromethamine; tropic acid; tyramine; undecylenic acid; Undecylenic acid; urea; urocanic acid; ursodiol; vardenafil; venlafaxine; verapamil; vitamin C; vitamin E acetate; voriconazole; Voriconazole; warfarin; xanthine; zafirlukast; zaleplon; zinc pyrithione; Zinc Selenium sulfide; ziprasidone; zolmitriptan; Zolpidem; WS-3; WS-23; menthol; 3-substituted-P-menthanes; N-substituted-P-menthane-3-carboxamides; isopulegol; 3-(l- menthoxy)propane-l,2-diol; 3-(l-menthoxy)-2-methylpropane-l,2-diol; p-menthane-2,3-diol; p-menthane-3,8-diol; 6-isopropyl-9-methyl-l,4-dioxaspiro[4,5]decane-2-methanol; menthyl succinate and its alkaline earth metal salts; trimethylcyclohexanol; N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide; Japanese mint oil; peppermint oil; menthone; menthone glycerol ketal; menthyl lactate; 3-(l-menthoxy)ethan-l-ol; 3-(l-menthoxy)propan-l-ol; 3-(l- menthoxy)butan-l-ol; 1-menthylacetic acid N-ethylamide; l-menthyl-4-hydroxypentanoate; 1-menthyl-3-hydroxybutyrate; N,2,3-trimethyl-2-(l-methylethyl)-butanamide; n-ethyl-t-2-c-6 nonadienamide; N,N-dimethyl menthyl succinamide; menthyl pyrrolidone carboxylate; aloe; avocado oil; green tea extract; hops extract; chamomile extract; colloidal oatmeal; calamine; cucumber extract; sodium palmate; sodium palm kernelate; butyrospermum parkii (i.e., shea

butter); menthe piperita (i.e.; peppermint) leaf oil; sericin; pyridoxine (a
form of vitamin B6); retinyl palmitate and/or other forms of vitamin A;
tocopheryl acetate and/or other forms of vitamin E; lauryl laurate; hyaluronic
acid; aloe barbadensis leaf juice powder; euterpe oleracea (i.e., acai berry)
fruit extract; riboflavin (i.e., vitamin B2); thiamin HC1 and/or other forms of
vitamin Bl; ethylenediaminetetraacetic acid (EDTA); citrate; ethylene
glycol tetraacetic acid (EGTA); l,2-bis(o-aminophenoxy)ethane-N,N,N',N'-
tetraacetic acid (BAPTA); diethylene triamine pentaacetic acid (DTPA); 2,3-
dimercapto-1-propanesulfonic acid (DMPS); dimercaptosuccinic acid
(DMSA); a-lipoic acid; salicylaldehyde isonicotinoyl hydrazone (SIH);
hexyl thioethylamine hydrochloride (HTA); desferrioxamine; ascorbic acid
(vitamin C); cysteine; glutathione; dihydrolipoic acid; 2-mercaptoethane
sulfonic acid; 2-mercaptobenzimidazole sulfonic acid; 6-hydroxy-2,5,7,8-
tetramethylchroman-2-carboxylic acid; sodium metabisulfite; vitamin E
isomers such as a-, p\ y-, and 8-tocopherols and a-, p\ y-, and 8-
tocotrienols; polyphenols such as 2-tert-butyl-4-methyl phenol, 2-tert-butyl-
5-methyl phenol, and 2-tert-butyl-6-methyl phenol; butylated
hydroxyanisole (BHA) such as 2-tert-butyl-4-hydroxyanisole and 3-tert-
butyl-4-hydroxyanisole; butylhydroxytoluene (BHT); tert-
butylhydroquinone (TBHQ); ascorbyl palmitate; n-propyl gallate; soy extract; soy isoflavones; retinoids such as retinol; kojic acid; kojic dipalmitate; hydroquinone; arbutin; transexamic acid; vitamins such as niacin and vitamin C; azelaic acid; linolenic acid and linoleic acid; placertia; licorice; and extracts such as chamomile and green tea; hydrogen peroxide; zinc peroxide; sodium peroxide; hydroquinone; 4-isopropylcatechol; hydroquinone monobenzyl ether; kojic acid; lactic acid; ascorbyl acid and derivatives such as magnesium ascorbyl phosphate; arbutin; licorice root; dihydroxyacetone (DHA); glyceryl aldehyde; tyrosine and tyrosine derivatives such as malyltyrosine, tyrosine glucosinate, and ethyl tyrosine; phospho-DOPA; indoles and derivatives; glucosamine; N-acetyl glucosamine; glucosamine sulfate; mannosamine; N-acetyl mannosamine; galactosamine; N-acetyl galactosamine; N-acyl amino acid compounds (e.g., N- undecylenoyl-L-phenylalanine); flavonoids such as quercetin, hesperidin, quercitrin, rutin, tangeritin, and epicatechin; CoQIO; vitamin C; hydroxy

acids including C2 -C30 alpha-hydroxy acids such as glycolic acid, lactic
acid, 2-hydroxy butanoic acid, malic acid, citric acid tartaric acid, alpha-
hydroxyethanoic acid, hydroxycaprylic acid and the like; beta hydroxy acids
including salicylic acid and polyhydroxy acids including gluconolactone
(G4); retinoic acid; gamma-linolenic acid; ultraviolet absorber of benzoic
acid system such as para-aminobenzoic acid (hereinafter, abbreviated as
PABA), PABA monoglycerin ester, N,N-dipropoxy PABA ethyl ester, N,N-
diethoxy PABA ethyl ester, N,N-dimethyl PABA ethyl ester, N,N-dimethyl
PABA butyl ester, and N,N-dimethyl PABA methyl ester and the like;
ultraviolet absorber of anthranilic acid system such as homomenthyl-N-
acetyl anthranilate and the like; ultraviolet absorber of salicylic acid system
such as amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl
salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl
salicylate and the like; ultraviolet absorber of cinnamic acid system such as
octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl
cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl
cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate,
isoamyl-p-methoxy cinnamate, octyl-p-methoxy cinnamate(2-ethylhexyl-p-
methoxy cinnamate), 2-ethoxyethyl-p-methoxy cinnamate, cyclohexyl-p-
methoxy cinnamate, ethyl-a-cyano-P-phenyl cinnamate, 2-ethylhexyl-a-
cyano-P-phenyl cinnamate, glyceryl mono-2-ethylhexanoyl-dipara-methoxy
cinnamate, methyl bis(trimethylsiloxane)silylisopentyl trimethoxy cinnamate
and the like; 3-(4'-methylbenzylidene)-d,l-camphor; 3-benzylidene-d,l-
camphor; urocanic acid, urocanic acid ethyl ester; 2-phenyl-5-
methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-
hydroxy-5' -t-octylphenyl)benzotriazole; 2-(2' -hydroxy-5' -
methylphenylbenzotriazole; dibenzaladine; dianisoylmethane; 4-methoxy-4'-t-butyldibenzoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentane-2-one; dimorpholinopyridazinone; titanium oxide; particulate titanium oxide; zinc oxide; particulate zinc oxide; ferric oxide; particulate ferric oxide; eerie oxide; inorganic sunscreens such as tianium dioxide and zinc oxide; organic sunscreens such as octyl- methyl cinnamates and derivatives thereof; retinoids; vitamins such as vitamin E, vitamin A, vitamin C (ascorbic acid), vitamin B, and derivatives thereof such as vitamin E acetate, vitamin C

palmitate, and the like; antioxidants including alpha hydroxy acid such as
glycolic acid, citric acid, lactic acid, malic acid, mandelic acid, ascorbic
acid, alpha-hydroxybutyric acid, alpha- hydroxyisobutyric acid, alpha-
hydroxyisocaproic acid, atrrolactic acid, alpha- hydroxyisovaleric acid, ethyl
pyruvate, galacturonic acid, glucopehtonic acid, glucopheptono-1 ,4-lactone,
gluconic acid, gluconolactone, glucuronic acid, glucurronolactone, glycolic
acid, isopropyl pyruvate, methyl pyruvate, mucic acid, pyruvia acid,
saccharic acid, saccaric acid 1 ,4-lactone, tartaric acid, and tartronic acid;
beta hydroxy acids such as beta-hydroxybutyric acid, beta-phenyl-lactic
acid, beta-phenylpyruvic acid; botanical extracts such as green tea, soy, milk
thistle, algae, aloe, angelica, bitter orange, coffee, goldthread, grapefruit,
hoellen, honeysuckle, Job's tears, lithospermum, mulberry, peony, puerarua,
rice, and safflower; 21-acetoxypregnenolone; alclometasone; algestone;
amcinonide; beclomethasone; betamethasone; budesonide;
chloroprednisone; clobetasol; clobetansone; clocortolone; cloprednol; corticosterone; cortisone; cortivazol; deflazacort; desonide; desoximetasone; dexamethasone; diflorasone; diflucortolone; difluprednate; enoxolone; fluazacort; flucloronide; flumethasone flunisolide; fluocinolone acetonide; fluocinonide; fluocortin butyl; fluocortolone; fluorometholone; fluperolone acetate; fluprednidene acetate; fluprednisolone; flurandrenolide; fluticasone propionate; formocortal; halcinonide; halobetasol propionate; halometasone; halopredone acetate; hydrocortamate; hydrocortisone; loteprednol etabonate; mazipredone; medrysone; meprednisone; methylprednisolone; mometasone furcate; paramethosone; prednicarbate; prednisolone; prednisolone 25-diethylamino-acetate; prednisolone sodium phosphate; prednisone; prednival; prednylidene; rimexolone; tixocortol; triamcinolone; triamcinolone acetonide; triamcinolone benetonide; triamcinolone hexacetonide; COX inhibitors such as salicylic acid derivatives (e.g., aspirin, sodium salicylate, choline magnesium trisalicylate, salicylate, diflunisal, sulfasalazine and olsalazine); para-aminophenol derivatives such as acetaminophen; indole and indene acetic acids such as indomethacin and sulindac; heteroaryl acetic acids such as tolmetin, dicofenac and ketorolac; arylpropionic acids such as ibuprofen, naproxen, flurbiprofen, ketoprofen, fenoprofen and oxaprozin; anthranilic acids (fenamates) such as mefenamic

acid and meloxicam; enolic acids such as the oxicams (piroxicam, meloxicam); alkanones such as nabumetone; diarylsubstituted furanones such as refecoxib; diaryl-substituted pyrazoles such as celecoxib; indole acetic acids such as etodolac; sulfonanilides such as nimesulide; selenium sulfide; sulfur; sulfonated shale oil; salicylic acid; coal tar; povidone-iodine, imidazoles such as ketoconazole, dichlorophenyl imidazolodioxalan, clotrimazole, itraconazole, miconazole, climbazole, tioconazole, sulconazole, butoconazole, fluconazole, miconazolenitrite; anthralin; piroctone olamine (Octopirox); ciclopirox olamine; anti-psoriasis agents; vitamin A analogs; corticosteroids; and any combinations thereof.
26. The particle of claim 25, wherein the pyrithione salt is selected from the group consisting of zinc pyrithione, sodium pyrithione, potassium pyrithione, lithium pyrithione, ammonium pyrithione, copper pyrithione, calcium pyrithione, magnesium pyrithione, strontium pyrithione, silver pyrithione, gold pyrithione, manganese pyrithione, and any combinations thereof.
27. The particle of claim 25, wherein the active agent is besifloxacin.
28. The particle of any of claims 1-27, wherein the particle has a size of from about 5 nm to about 20 um.
29. The particle of claim 28, wherein the particle has a size of from about 100 nm to about 10 um.
30. The particle of claim 29, wherein the particle has a size of from about 200 nm to about 6 um.
31. The particle of claim 30, wherein the particle has a size of from about 1 um to about 6um.
32. The particle of claim 30, wherein the particle has a size of from about 300 nm to about 700 nm.
33. The particle of any of claims 1-32, wherein the coating layer has a thickness of: (i) from about 1 nm to about 1000 nm.
34. The particle of claim 33, wherein the coating layer has a thickness of from about 1 nm to about 150 nm.
35. The particle of any of claims 1-34, wherein the active agent is present in an amount from about 1% to about 99% (w/w).

36. The particle of claim 35, wherein the active agent is present in an amount from about 75% to about 98% (w/w).
37. The particle of any of claims 1 or 5-36, wherein the lipid is selected from the group consisting of fatty acids; mono-, di- or tri-esters of fatty acids; salts of fatty acids; fatty alcohols; mono-, di- or tri-esters of fatty alcohols; glycerolipids; phospholipids; glycerophospholipids; sphingolipids; sterol lipids; prenol lipids; saccharolipids; polyketides; and any combination thereof.
38. The particle of any of claims 1 or 5-36, wherein the lipid is selected from the group consisting of 1,3-Propanediol Dicaprylate/Dicaprate; 10-undecenoic acid; 1-dotriacontanol; 1-heptacosanol; 1-nonacosanol; 2-ethyl hexanol; Androstanes; Arachidic acid; Arachidonic acid; arachidyl alcohol; Behenic acid; behenyl alcohol; Capmul MCM CIO; Capric acid; capric alcohol; capryl alcohol; Caprylic acid; Caprylic/Capric Acid Ester of Saturated Fatty Alcohol C12-C18; Caprylic/Capric Triglyceride; Caprylic/Capric Triglyceride; Ceramide phosphorylcholine (Sphingomyelin, SPH); Ceramide phosphorylethanolamine (Sphingomyelin, Cer-PE); Ceramide phosphorylglycerol; Ceroplastic acid; Cerotic acid; Cerotic acid; ceryl alcohol; Cetearyl alcohol; Ceteth-10; cetyl alcohol; Cholanes; Cholestanes; cholesterol; cis-11-eicosenoic acid; cis-11-octadecenoic acid; cis-13-docosenoic acid; cluytyl alcohol; coenzyme Q10 (CoQIO); Dihomo-y-linolenic; Docosahexaenoic acid; egg lecithin; Eicosapentaenoic acid; Eicosenoic acid; Elaidic acid; elaidolinolenyl alcohol; elaidolinoleyl alcohol; elaidyl alcohol; Erucic acid; erucyl alcohol; Estranes; Geddic acid; geddyl alcohol; glycerol distearate (type I) EP (Precirol ATO 5); Glycerol Tricaprylate/Caprate; Glycerol Tricaprylate/Caprate (CAPTEX® 355 EP/NF); glyceryl monocaprylate (Capmul MCM C8 EP); Glyceryl Triacetate; Glyceryl Tricaprylate; Glyceryl Tricaprylate/Caprate/Laurate; Glyceryl Tricaprylate/Tricaprate; glyceryl tripalmitate (Tripalmitin); Henatriacontylic acid; Heneicosyl alcohol; Heneicosylic acid; Heptacosylic acid; Heptadecanoic acid; Heptadecyl alcohol; Hexatriacontylic acid; isostearic acid; isostearyl alcohol; Lacceroic acid; Laurie acid; Lauryl alcohol; Lignoceric acid; lignoceryl alcohol; Linoelaidic acid; Linoleic acid; linolenyl alcohol; linoleyl alcohol; Margaric acid; Mead; Melissic acid;

melissyl alcohol; Montanic acid; montanyl alcohol; myricyl alcohol; Myristic acid; Myristoleic acid; Myristyl alcohol; neodecanoic acid; neoheptanoic acid; neononanoic acid; Nervonic; Nonacosylic acid; Nonadecyl alcohol; Nonadecylic acid; Nonadecylic acid; Oleic acid; oleyl alcohol; Palmitic acid; Palmitoleic acid; palmitoleyl alcohol; Pelargonic acid; pelargonic alcohol; Pentacosylic acid; Pentadecyl alcohol; Pentadecylic acid; Phosphatidic acid (phosphatidate, PA); Phosphatidylcholine (lecithin, PC); Phosphatidylethanolamine (cephalin, PE); Phosphatidylinositol (PI); Phosphatidylinositol bisphosphate (PIP2); Phosphatidylinositol phosphate (PIP); Phosphatidylinositol triphosphate (PIP3); Phosphatidylserine (PS); polyglyceryl-6-distearate; Pregnanes; Propylene Glycol Dicaprate; Propylene Glycol Dicaprylocaprate; Propylene Glycol Dicaprylocaprate; Psyllic acid; recinoleaic acid; recinoleyl alcohol; Sapienic acid; soy lecithin; Stearic acid; Stearidonic; stearyl alcohol; Tricosylic acid; Tridecyl alcohol; Tridecylic acid; Triolein; Undecyl alcohol; undecylenic acid; Undecylic acid; Vaccenic acid; a-Linolenic acid; y-Linolenic acid; a fatty acid salt of 10-undecenoic acid, adapalene, arachidic acid, arachidonic acid, behenic acid, butyric acid, capric acid, caprylic acid, cerotic acid, cis-11-eicosenoic acid, cis-11-octadecenoic acid, cis-13-docosenoic acid, docosahexaenoic acid, eicosapentaenoic acid, elaidic acid, erucic acid, heneicosylic acid, heptacosylic acid, heptadecanoic acid, isostearic acid, lauric acid, lignoceric acid, linoelaidic acid, linoleic acid, montanic acid, myristic acid, myristoleic acid, neodecanoic acid, neoheptanoic acid, neononanoic acid, nonadecylic acid, oleic acid, palmitic acid, palmitoleic acid, pelargonic acid, pentacosylic acid, pentadecylic acid, recinoleaic acid, sapienic acid, stearic acid, tricosylic acid, tridecylic acid, undecylenic acid, undecylic acid, vaccenic acid, valeric acid, a-linolenic acid, or y-linolenic acid; paraffin; and any combinations thereof.
39. The particle of claim 38, wherein the fatty acid salt is selected from the group consisting of zinc, sodium, potassium, lithium, ammonium, copper, calcium, magnesium, strontium, manganese, and combinations thereof.
40. The particle of any of claims 1 or 5-36, wherein the lipid comprises 11 or fewer carbon atoms.

41. The particle of any of claims 1 or 5-36, wherein the lipid is selected from the group consisting of ethylene glycol distearate (EGDS), caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, zinc recinoleate, CoQIO, paraffin, triplamitin, polyglyceryl-6-distearate, and any combinations thereof.
42. The particle of any of claims 1 or 5-36, wherein the lipid is present in an amount from about 1% to about 99% (w/w).
43. The particle of claim 42, wherein the lipid is present in an amount from about 2% to about 25 % (w/w).
44. The particle of any of claims 1 or 5-36, wherein the particle comprises an excess of the active agent relative to the total lipids.
45. The particle of any of claims 1 or 5-36, wherein ratio of total lipid to the active agent in the particle is from about 100:1 to about 1:100.
46. The particle of claim 45, wherein ratio of total lipid to the active agent in the particle is from about 100:1 to about 1:100.
47. The particle of claim 46, wherein the ratio of total lipid to the active agent in the particle is from about 10:1 to about 1:50.
48. The particle of claim 47, wherein ratio of total lipid to the active agent in the particle is about 2:1 to about 1:30.
49. The particle of any of claims 3 or 5-36, wherein the protein is selected from the group consisting of Actin, Albumin, Amaranth Protein, Ammonium Hydrolyzed Animal Protein, Animal protein, Barley Protein, Brazil Nut Protein, Casein, Collagen, Collagen protein hydrolyzed, Conchiolin Protein, corn protein, Cottonseed Protein, Elastin, Extensin, Fibroin, Fibronectin, Fish Protein, Gadidae Protein, Gelatin, Glutein, Glycoproteins, Hazelnut Protein, Hemoglobin, Hemp Seed Protein, Honey Protein, Hydrolyzed Actin, Hydrolyzed Amaranth Protein, Hydrolyzed animal protein, Hydrolyzed Barley Protein, Hydrolyzed Brazil Nut Protein, Hydrolyzed Conchiolin Protein, Hydrolyzed corn protein, Hydrolyzed Cottonseed Protein, Hydrolyzed Elastin, Hydrolyzed Extensin, Hydrolyzed Fibroin, Hydrolyzed Fibronectin, Hydrolyzed Fish Protein, Hydrolyzed Gadidae Protein, Hydrolyzed Gadidae Protein, Hydrolyzed Gelatin, Hydrolyzed Hair Keratin, Hydrolyzed Hazelnut, Hydrolyzed Hazelnut Protein, Hydrolyzed Hemoglobin, Hydrolyzed Hemp Seed Protein, Hydrolyzed Honey Protein,

Hydrolyzed Keratin, Hydrolyzed Lupine Protein, Hydrolyzed Maple Sycamore Protein, Hydrolyzed Milk Protein, Hydrolyzed Oat Protein, Hydrolyzed Pea Protein, Hydrolyzed Potato Protein, Hydrolyzed Reticulin, Hydrolyzed Royal Jelly Protein, Hydrolyzed Sericin, Hydrolyzed Serum Protein, Hydrolyzed Sesame Protein, Hydrolyzed Soy Protein, Hydrolyzed Soymilk Protein, Hydrolyzed Spinal Protein, Hydrolyzed Spongin, Hydrolyzed Sweet Almond Protein, Hydrolyzed Vegetable Protein, Hydrolyzed Wheat Gluten, Hydrolyzed Wheat Protein, Hydrolyzed Whey Protein, Hydrolyzed Yeast Protein, Hydrolyzed Yogurt Protein, Hydrolyzed Zein, Integrin, Jojoba protein HP, Hydrolyzed, keratin, Lupine Protein, Maple Sycamore Protein, MEA-Hydrolyzed Collagen, MEA-Hydrolyzed Silk, Milk Protein, Myosin, Oat Protein, Pea Protein, polylysine, Potato Protein, Reticulin, Rice Quat, Royal Jelly Protein, Sericin, Serum Protein, Sesame Protein, Silk powder, Sodium Hydrolyzed Casein, Soy Protein, Soy Rice Peptides, Soymilk Protein, Spinal Protein, Spongin, Sweet Almond Protein, Vegetable Protein, Wheat Gluten, Whey Protein, Yeast Protein, Yogurt Protein, Zein, and Zinc Hydrolyzed Collagen.
50. The particle of claim 49, wherein the albumin is bovine serum albumin, egg albumin, Hydrolyzed Lactalbumin, or Lactalbumin.
51. The particle of any of claims 3 or 5-36, wherein the protein is present in an amount from about 1% (w/w) to about 99% (w/w).
52. The particle of claim 51, wherein the protein is present in an amount from about 5% (w/w) to about 50% (w/w).
53. The particle of any of claims 3 or 5-36, wherein ratio of the protein to the active agent in the particle is from about 100:1 to about 1:100.
54. The particle of claim 53, wherein ratio of the protein to the active agent in the particle is about 10:1 to about 1:50.
55. The particle of claim 54, wherein ratio of the protein to the active agent in the particle is about 2:1 to about 1:30.
56. The particle of any of claims 4-36, wherein the cationic molecule is a poly amine.
57. The particle of claim 56, wherein the cationic molecule is selected from the group consisting of Putrescine (Butane- 1,4-diamine), Cadaverine (Pentane-1,5-diamine), Spermidine, Spermine, Cyclen (1,4,7,10-

tetrazacyclododecane), Cyclam (1,4,8,11-Tetraazacyclotetradecane), Linear
Polyethyleneimine (Poly(iminoethylene)), Norspermidine, p-
Phenylenediamine (1,4-diaminobenzene), Diethylenetriamine (N-(2-aminoethyl)-l,2-ethanediamine), thermospermine, Tris(2-aminoethyl)amine, Hexamethylenediamine, Beta-lysine (3,6-diaminohexanoic acid), m-Phenylenediamine (1,3-diaminobenzene), Diaminopropane (1,2-Diaminopropane), Ethylenediamine dihydroiodide, and polyamine D 400 (Polyoxyalkyleneamine D 400).
58. The particle of any of claims 4-36, wherein the cationic molecule is present in an amount from about 1% (w/w) to about 99% (w/w).
59. The particle of claim 58, wherein the cationic molecule is present in an amount from about 5% (w/w) to about 50% (w/w).
60. The particle of any of claims 4-36, wherein ratio of the cationic molecule to the active agent in the particle is from about 100:1 to about 1:100.
61. The particle of claim 60, wherein ratio of the cationic molecule to the active agent in the particle is about 10:1 to about 1:50.
62. The particle of claim 61, wherein ratio of the cationic molecule to the active agent in the particle is about 2:1 to about 1:30.
63. The particle of any of claims 2 or 5-36, wherein the carbohydrate is selected from the group consisting of oligosaccharides, polysaccharides, glycoproteins, glycolipids and any combinations thereof.
64. The particle of claim 63, wherein the carbohydrate is selected from the group consisting of fructooligosaccharide, galactooligosaccharides, mannanoligosaccharides, glycogen, starch, glycosaminoglycans, cellulose, beta-glucan, maltodextrin, inulin, levan beta (2->6), chitin, chitosan, and any combinations thereof.
65. The particle of any of claims 2 or 5-36, wherein the carbohydrate is present in an amount from about 1% (w/w) to about 99% (w/w).
66. The particle of claim 65, wherein the carbohydrate is present in an amount from about 5% (w/w) to about 50% (w/w).
67. The particle of any of claims 2 or 5-36, wherein ratio of the carbohydrate to the active agent in the particle is from about 100:1 to about 1:100.
68. The particle of claim 67, wherein ratio of the carbohydrate to the active agent in the particle is about 10:1 to about 1:50.

69. The particle of claim 68, wherein ratio of the carbohydrate to the active agent in the particle is about 2:1 to about 1:30.
70. A composition comprising an effective amount of particle of any of claims 1-69.
71. The composition of claim 70, wherein the composition comprises from about 0.01% to about 50% (w/w or w/v) of the particles.
72. The composition of claim 71, wherein the composition comprises from about 10%) to about 30%> (w/w or w/v) of the particles.
73. The composition of any of claims 70-72, wherein the composition further comprises one or more excipients.
74. The composition of claim 73, wherein the composition comprises from about 5%> to about 99.99%> (w/w or w/v) of the one or more excipients.
75. The composition of claim 73 or 74, wherein the excipient is a solvent or an additive.
76. The composition of any of claims 73-75, wherein the additive is selected from the group consisting of surfactants, stabilizers, rheology modifiers, conditioning agents, fragrances, potentiating agents, preservatives, opacifiers, pH modifiers, moisturizers, humectants, suspending agents, solubilizers, and any combinations thereof.
77. The composition of claim 76, wherein the additive is selected from the group consisting of 45° Be'glucose syrup, Acrylates/10-30 alkyl acrylate crosspolymer, Acrylates/Acrylamide Copolymer , agar, Allantoin, Aminomethyl propanol, Ammonium lauryl sulfate (ALS), Amodimethicone emulsion, AMP-Acrylates/Allyl Methacrylate Copolymer, Behentrimonium methosulfate, Benzophenone-4, Butylene glycol, Carbapol Aqua SF-1, Carbapol-934, Carbapol-940, Carbopol, Carboxymethyl cellulose, Cassia hydroxy propyltrimoniumchloride, Cetearyl alcohol, Cetearyl alcohol, Cetearyl isononanoate, Cetrimoniumchloride (CTC), Cetyl Alcohol, Cetyl octanoate, Chloromethyl/Methylisothiazolinone, Chloromethyl/Methylisothiazolinone, Citric acid, Citrus Aurantium Dulcis (Orange) Fruit Extract, Cocamidopropyl betain (CAPB), Cocamidopropyl betain (CAPB), Coco monoethanolamide (CMEA), Cocodimonium hydroxypropyl hydrolyzed wheat protein, Coloring agent, CPB, Diisopropyl sebacate, Dimethicone PEG-7 Isostearate, Disodium EDTA, DMDM

hydantoin, Dove AD shine, Emulsifying wax, Ethanol, Ethylene glycol
distearate (EGDS), Ethylhexyl methoxycinnamate, eucalyptol, Flavors, Forte
therapy, Fragrance, Glycerin, Glycerine, Glyceryl monohydroxystearate,
Glyceryl monostearate, Glycolic acid, Guar gum, Gum base, Hyaluronic
acid, Hydrated silica, Hydrolyzed silk protein, Intense repair, Lactamide
MEA acetamide MEA, Lactic acid, Limnanthes Alba (Meadowfoam) Seed
Oil, Linalool, Linoleamidopropyl PG-dimonium chloride phosphate,
Macrogolcetostearyl ether 20, magnese chloride,, Magnesium sulfate,
Menthol, Methyl gluceth-20, methyl salicylate, Mineral oil, Mint-type
flavor, PEG/PPG-8/3 laurate, PEG-12 dimethicone, PEG-20 Almond
Glycerides, PEG-40 hydrogenated castor oil, PEG-80 glyceryl cocoate,
peppermint oil, Phenyl trimethicone, Polyacrylate-1 crosspolymer,
Polyethylene glycol 1450, Polyoxyethylene/polyoxypropylene block
polymer (Poloxamer 407), Polyquaternium-22, Polyquaternium-39,
Polysorbate 85, polysorbate-20, PPG-3 myristyl ether, Preservative,
Propylene glycol, Propylene glycol monocaprylate, Prunus Armeniaca
(Apricot) Kernel Oil, Pyrus Malus (Apple) Fruit Extract, retinyl palmitate,
Saccharin sodium, Salicylic acid, Sensomer CT-250, Silica Xerogel, SLES,
SLS, sodium chloride, sodium docusate, Sodium hydroxide, Sodium lauryl
ether sulfate (SLES), sodium lauryl sulphate, Sodium monofluorophosphate,
Sodium saccharin, Sorbitol, Stearamidopropyldimethylamine, Steareth-2,
Steareth-21, Stearic acid, Sugar powder, sunflower seed oil, Tea tree oil,
Titanium dioxide, Tocopheryl acetate, Triclosan, Triethanolamine, Wheat
amino acids, Xanthan gum, zinc carbonate, zinc chloride, zinc recinoleate,
zinc stearate, and any combinations thereof.
78. The composition of any of claims 70-77, wherein the composition further
comprises: (i) Carbopol, Ammonium lauryl sulfate (ALS), Sodium lauryl ether sulfate (SLES), Sodium hydroxide, Coco monoethanolamide (CMEA), Ethylene glycol distearate (EGDS), Propylene glycol monocaprylate, Menthol, Magnesium sulfate, Amodimethicone emulsion, Propylene glycol, Zinc carbonate, Cocamidopropyl betaine (CAPB), Cassia hydroxyl propyltrimoniumchloride, Chloromethyl/Methylisothiazolinone, Linalool, Fragrance, Citric acid, and Sodium Chloride; or (ii) Carbopol, Ammonium lauryl sulfate (ALS), Sodium lauryl ether sulfate (SLES), Sodium hydroxide,

Ethylene glycol distearate (EGDS), Propylene glycol monocaprylate, Menthol, Magnesium sulfate, Amodimethicone emulsion, Propylene glycol, Zinc carbonate, Cocamidopropyl betaine (CAPB), Cassia hydroxyl propyltrimoniumchloride, Chloromethyl/Methylisothiazolinone, Linalool, Fragrance, Citric acid, and Sodium Chloride.
79. The composition of any of claims 70-77, wherein the composition further
comprises: (i) Carbopol, Sodium lauryl ether sulphate (SLES), Sodium
hydroxide, Steareth-2, Steareth-21, Propylene glycol monocaprylate,
Macrogolcetostearyl ether 20, Coco monoethanolamide (CMEA), Cetyl
Alcohol, Stearamidopropyldimethylamine, Lactic acid, Cocamidopropyl
betain (CAPB), Cetrimoniumchloride (CTC), Polyquaternium-22,
Amodimethicone emulsion, Cassia hydroxy propyltrimoniumchloride,
Propylene glycol, Glycerine, Zinc carbonate, Titanium dioxide, Linalool,
Fragrance, and Chloromethyl/Methylisothiazolinone; or (ii) Carbopol,
Sodium lauryl ether sulphate (SLES), Sodium hydroxide, Steareth-2,
Steareth-21, Propylene glycol monocaprylate, Macrogolcetostearyl ether 20,
Coco monoethanolamide (CMEA), Cetyl Alcohol,
Stearamidopropyldimethylamine, Lactic acid, Cocamidopropyl betain
(CAPB), Cetrimoniumchloride (CTC), Polyquaternium-22,
Amodimethicone emulsion, Cassia hydroxy propyltrimoniumchloride,
Propylene glycol, Glycerine, Titanium dioxide, Linalool, Fragrance, and
Chloromethyl/Methylisothiazolinone.
80. The composition of any of claims 70-77, wherein the composition further
comprises: (i) Stearic acid, Mineral oil, Glyceryl monostearate, Glyceryl
monohydroxystearate, Cetearyl alcohol, Cetyl octanoate, Emulsifying wax,
Cabopol, Triethanolamine, Water, Glycerin, Propylene glycol, Fragrance,
and Preservative; (ii) Stearic acid, Mineral oil, Glyceryl monostearate,
Glyceryl monohydroxystearate, Cetearyl alcohol, Cetyl octanoate, Cabopol,
Triethanolamine, Glycerin, Salicylic acid, Citrus Aurantium Dulcis (Orange)
Fruit Extract, Fragrance, and Preservative; (iii) Emulsifying wax,
Behentrimonium methosulfate and Cetearyl alcohol, PPG-3 myristyl ether,
Cetearyl isononanoate, Dimethicone PEG-7 Isostearate, Ethylhexyl
methoxycinnamate, Cabopol, Acrylates/Acrylamide Copolymer (and)
Mineral Oil, (and) Polysorbate 85, Triethanolamine, Glycerin, Hyaluronic

acid, Wheat amino acids, Lactamide MEA and acetamide MEA, Hydrolyzed silk protein, Salicylic acid, Propylene glycol, Pyrus Malus (Apple) Fruit Extract, Citrus Aurantium Dulcis (Orange) Fruit Extract, Tocopheryl acetate, Fragrance, and Preservative; or (iv) Glyceryl monohydroxystearate, Limnanthes Alba (Meadowfoam) Seed Oil, Prunus Armeniaca (Apricot) Kernel Oil, Phenyl trimethicone, Diisopropyl sebacate, Ethylhexyl methoxycinnamate, Cabopol, Acrylates/Acrylamide Copolymer (and) Mineral Oil, (and) Polysorbate 85, AMP-Acrylates/Allyl Methacrylate Copolymer, Triethanolamine, PEG-20 Almond Glycerides, Titanium dioxide, Propylene glycol, Linoleamidopropyl PG-dimonium chloride phosphate, Cocodimonium hydroxypropyl hydrolyzed wheat protein, Tocopheryl acetate, Fragrance, and Preservative.
81. The composition of any of claims 70-77, wherein the composition further comprises: (i) Glycerin, Methyl gluceth-20, Benzophenone-4, Acrylates/10-30 alkyl acrylate crosspolymer, PEG/PPG-8/3 laurate, Aminomethyl propanol, Polyquaternium-39, PEG-80 glyceryl cocoate, Coloring agent, Preservative, and Fragrance; (ii) Disodium EDTA, Propylene glycol, Carbopol, Aminomethyl propanol, Tea tree oil, PEG-40 hydrogenated castor oil, polysorbate-20, Coloring agent, Preservative, and Fragrance; (iii) Butylene glycol, Glycerin, Methyl gluceth-20, Allantoin, Disodium EDTA, PEG-12 dimethicone, Polyacrylate-1 crosspolymer, Gly colic acid, Triethanolamine, Tocopheryl acetate, retinyl palmitate, sunflower seed oil, agar, Coloring agent, Preservative, and Fragrance; or (iv) Glycerin, Methyl gluceth-20, Carbopol, Triethanolamine, Ethanol, Triclosan, Coloring agent, Preservative, and Fragrance.
82. The composition of any of claims 70-77, wherein the composition further comprises Carboxymethyl cellulose, Polyethylene glycol 1450, Sorbitol, Glycerin, Sodium monofluorophosphate, Sodium saccharin, Preservative, Coloring agent, Silica Xerogel, Hydrated silica, Mint-type flavor, and Sodium lauryl sulfate.
83. The composition of any of claims 70-77, wherein the composition further comprises Ethyl alcohol, menthol, methyl salicylate, peppermint oil, eucalyptol, Glycerin, Polyoxyethylene/polyoxypropylene block polymer (Poloxamer 407), and Saccharin sodium.

84. The composition of any of claims 70-77, wherein the composition further comprises Gum base, 45° Be'glucose syrup, Sugar powder, Flavors, Glycerin, and Preservative
85. The composition of any of claims 70-84, wherein the composition is a cream, oil, lotion, serum, gel, shampoo, conditioner, tooth paste, mouth wash, chewing gum, sun screen, nail varnish, ointment, foam, spray, or aerosol.
86. The composition of any of claims 70-84, wherein the composition is an anti-dandruff hair care composition selected from the group consisting of a shampoo, a conditioner, a rinse, a lotion, an aerosol, a gel, a mousse, and a hair dye.
87. The composition of any of claims 70-84, wherein the composition is a skin care composition selected from the group consisting of lotions, creams, gels, sticks, sprays, ointments, cleansing liquid washes, cleansing solid bars, pastes, foams, powders, shaving creams, and wipes.
88. The composition of any of claims 70-84, wherein the composition is an oral care composition selected from the group consisting of tooth pastes, mouth washes, and chewing gums.
89. The composition of any of claims 70-84, wherein the composition is an antifungal, antibacterial, anti-inflammatory, anti-aging, anti-wrinkle, or skin whitening or skin bleaching composition.
90. The composition of any of claims 70-84, wherein the composition is an anti-acne composition.
91. The composition of any of claims 70-84, wheren the composition is a shampoo, the active agent is an anti-fungal agent and the coating layer lipid is EGDS, and wherein the excipient is propylene glycol monocaprylate.
92. The composition of any of claims 70-84, wheren the composition is a gel or cream, wherein the active agent is an anti-propionibacterium agent and the coating layer lipid is Laurie acid and/or stearic acid, and wherein the excipient is TPGS.
93. The particle of any of claims 1-48, wherein the lipid is stable in shampoo formulation and acts a food for a pathogen.

94. The particle of any of claims 1-48, wherein the lipid is stable in shampoo formulation and enhances targeting, binding, or retention of the active agent to a desired site of action.
95. The particle of any of claims 1-48, wherein the lipid is stable in shampoo formulation and has a synergistic effect on activity of the active agent.