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"Color Imaging Element And Method Of Manufacturing The Same Photosensor And Method Of Manufacturing The Same, Photoelectric Transducer And Method Of Manufacturing The Same, And Electronic Device"

Abstract: A color imaging element, a photosensor and a photoelectric transducer which use a protein and are capable of being stably used for a long time, and methods of manufacturing them are provided. A zinc-substituted cytochrome c552 13 is immobilized on a gold electrode 11 with a self-assembled monolayer 12 in between to form a blue-light photoelectric transducer. Alternatively, a cytochrome c552 is immobilized on a gold electrode with a self-assembled monolayer in between, and a fluorescent protein absorbing blue light is bonded to the cytochrome c552, thereby forming a blue-light photoelectric transducer. These photoelectric transducers each are used as a color imaging element or a blue-light photoelectric transducer of a photosensor.

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Patent Information

Application #
Filing Date
10 August 2011
Publication Number
05/2012
Publication Type
INA
Invention Field
ELECTRICAL
Status
Email
Parent Application

Applicants

SONY CORPORATION
1-7-1 KONAN, MINATO-KU, TOKYO 1080075, JAPAN

Inventors

1. SEIJI YAMADA
C\O SONY CORPORATION, 1-7-1 KONAN, MINATO-KU, TOKYO 1080075, JAPAN
2. YUICHI TOKITA
C\O SONY CORPORATION, 1-7-1 KONAN, MINATO-KU, TOKYO 1080075, JAPAN
3. YOUSHIO GOTO
C\O SONY CORPORATION, 1-7-1 KONAN, MINATO-KU, TOKYO 1080075, JAPAN
4. WEI LUO
C\O SONY CORPORATION, 1-7-1 KONAN, MINATO-KU, TOKYO 1080075, JAPAN
5. DAISUKE YAMAGUCHI
C\O SONY CORPORATION, 1-7-1 KONAN, MINATO-KU, TOKYO 1080075, JAPAN
6. DAISUKE ITO
C\O SONY CORPORATION, 1-7-1 KONAN, MINATO-KU, TOKYO 1080075, JAPAN
7. JUSUKE SHIMURA
C\O SONY CORPORATION, 1-7-1 KONAN, MINATO-KU, TOKYO 1080075, JAPAN

Specification

DESCRIPTION [Title of Invention] COLOR IMAGING ELEMENT AND METHOD OF MANUFACTURING THE SAME, PHOTOSENSOR AND METHOD OF MANUFACTURING THE SAME, PHOTOELECTRIC TRANSDUCER AND METHOD OF MANUFACTURING THE SAME, AND ELECTRONIC DEVICE TECHNICAL FIELD [0001] The present invention relates to a color imaging element, a photosensor and a photoelectric transducer using a protein, and methods of manufacturing the same, and an electronic device using the above-described color imaging element, photosensor or photoelectric transducer. BACKGROUND ART [0002] Proteins are promising functional elements as an alternative to semiconductor elements. While miniaturization of semiconductor elements is limited to a size of several tens of nanometers, proteins with an extremely small size of 1 nm to 10 nm exert a sophisticated function. In related art, as a photoelectric transducer using a protein, there is proposed a photoelectric transducer using a protein-immobilized electrode formed by immobilizing a zinc-substituted cytochrome c (a horse-heart cytochrome c having zinc substituted for iron as a central metal of a heme) on a gold electrode, and it is reported that a photocurrent is obtained by the protein-immobilized electrode (refer to PTL 1). [0003] Moreover, there are proposed color picture light-sensitive elements including light-sensitive units having a photoelectric conversion function and being formed by supporting an alignment film of a photosensitive chromoprotein such as bacteriorhodopsin on an electrode, and including a plurality of combinations of light-sensitive units of photosensitive chromoproteins with different photosensitive wavelengths (refer to PTLs 2 and 3). [0004] [Citation list] [Patent Literature] [PTL 1] Japanese Unexamined Patent Application Publication No. 2007-220445 [PTL 2] Japanese Unexamined Patent Application Publication No. H3-237769 [PTL 3] Japanese Unexamined Patent Application Publication No. H3-252530 [NPTL 1] Fee, J.A.and 13 others, Protein Sci. 9,2074(2000) [NPTL 2] Vanderkooi, J.M. and 2 others, Eur. J.Biochem. 64, 381-387(1976) [NPTL 3] [Searched on July 15, 2008] the Internet (URL: http://www.wako-chem.co.jp/siyakii/info/gene/article/EvrogenSeries.htm) [NPTL 4] [Searched on July 15, 2008] the Internet (URL: http://clontech.takara-bio.co .j p/product/faniilies/gfp/lc_table2. shtml) [NPTL 5] [Searched on July 15, 2008] the Internet (URL: http://clontech.takara-bio.co.jp/product/catalog/200708_12.shtml) [NPTL 6] Choi, J.-M. and Fujihira M. Appl. Phys. Lett.84, 2187-2189 (2004) [NPTL 7] Robert K. and 2 others, Isolation and modification of natural porphyrins, in "The Porphyrins, vol. I" (Dolphin D. ed.), pp.289-334, Academic press, New York, 1978. [NPTL 8] Fuhrhop J.H., Irreversible reactions on theporphyrin periphery (excluding oxidations reductions, and photochemicalreactions), in "The Porphyrins, vol. II" (Dolphin D ed.) pp.131-156, Academic Press, New York, 1978. [NPTL 9] McDonagh A.F., Bile pigments: bilatrienes and 5,15-biladienes, in "The Porphyrins, vol. VI" (Dolphin D ed.) pp.294-472, Academic Press, New York, 1979. [NPTL 10] Jackson AH., Azaporphyrins, in "The Porphyrins, vol. I" (Dolphin D ed.), pp. 3 65-3 87, Academic Press, New York, 1978. [NPTL 11] Gouterman M., Optical spectra and electronicstructure of porphyrins and related rings, in "The Porphyrinis, vol. Ill" (Dolphin D ed.), pp. 1-156, Academic Press, New York, 1978. [NPTL 12] Gouterman M., Optical spectra and electronicstructure of porphyrins and related rings, in "The Porphyrinis, vol. m"(Dolphin D ed.), pp.11-30, Academic Press, New York, 1978. [NPTL 13] Sano S., Reconstitution of hemoproteins, in"The Porphyrins, vol. VII" (Dolphin D. ed.), pp.391-396, Academic Press, New York, 1979. SUMMARY OF THE INVENTION [0005] However, as the proteins used in the photoelectric transducer and the color picture light-sensitive elements proposed in PTLs 1 to 3 are unstable in vitro, there is an issue that the photoelectric transducer and the color picture light-sensitive elements lack long stability. When the photoelectric transducer and the color picture light-sensitive elements are allowed to achieve long stability, they are extremely useful; however, as far as the inventors and others of the present invention are aware, there have been no reports describing such a photoelectric transducer or color picture light-sensitive element. Therefore, an object to be achieved by the present invention is to provide a color imaging element which uses a protein and is capable of being stably used for a long time, and a method of manufacturing the same. Another object to be achieved by the invention is to provide a photosensor which uses a protein and is capable of being stably used for a long time, and a method of manufacturing the same. Still another object to be achieved by the invention is to provide a photoelectric transducer which uses a protein and is capable of being stably used for a long time, and a method of manufacturing the same. A further object to be achieved by the invention is to provide an electronic device using the above-described superior color imaging element, photosensor or photoelectric transducer. The above-described objects and other objects will become apparent from the description of the present specification and the accompanying drawings. [0006] To achieve the above-described objects, the present invention provides a color imaging element including: a blue-light photoelectric transducer using a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof. Moreover, the present invention provides a method of manufacturing a color imaging element including: a step of immobilizing a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof on an electrode. [0007] Further, the present invention provides a photosensor including a blue-light photoelectric transducer using a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof. Moreover, the present invention provides a method of manufacturing a photosensor including: a step of immobilizing a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof on an electrode. [0008] Moreover, the present invention provides a blue-light photoelectric transducer using a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof. Further, the present invention provides a method of manufacturing a blue-light photoelectric transducer including: a step of immobilizing a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof on an electrode. [0009] Moreover, the present invention provides a red-light or green-light photoelectric transducer using a cytochrome c552 modified zinc-porphyrin. Further, the present invention provides a method of manufacturing a red-light or green-light photoelectric transducer including: a step of immobilizing a cytochrome c552 modified zinc-porphyrin on an electrode. [0010] In the above-described respective inventions, as a material of an electrode on which the zinc-substituted cytochrome c552, the derivative thereof or the variant thereof, or the cytochrome c552 modified zinc-porphyrin is immobilized, a gold electrode is most preferably used; however, any other material may be used. More specifically, as an inorganic material, for example, in addition to a metal such as platinum or silver, a metal oxide such as ITO (indium-tin oxide), FTO (fluorine-doped tin oxide) or Nesa glass (SnO2) may be used. Moreover, as an organic material, for example, various conductive polymers and a charge-transfer complex (for example, TTF-TCNQ or the like) containing a tetrathiafulvalene derivative (such as TTF, TMTSF, or BEDT-TTF) may be used. As the conductive polymer, for example, polythiophene, polypyrrole, polyacetylene, polydiacetylene, polyparaphenylene, polyparaphenylene sulfide or the like may be used. [0011] Moreover, the present invention provides a color imaging element including a red-light, green-light or blue-light photoelectric transducer, the red-light, green-light or blue-light photoelectric transducer using: a gold electrode; a cytochrome c552, a derivative thereof or a variant thereof immobilized on the gold electrode; and a fluorescent protein bonded to the cytochrome c552, the derivative thereof or the variant thereof and absorbing red light, green light or blue light. Further, the present invention provides a method of manufacturing a color imaging element including: a step of immobilizing a cytochrome c552, a derivative thereof or a variant thereof on a gold electrode; and a step of bonding a fluorescent protein absorbing red light, green light or blue light to the cytochrome c552, the derivative thereof or the variant thereof. [0012] Moreover, the present invention provides a photosensor including: a gold electrode; a cytochrome c552, a derivative thereof or a variant thereof immobilized on the gold electrode; and a fluorescent protein bonded to the cytochrome c552, the derivative thereof or the variant thereof. Further, the present invention provides a method of manufacturing a photosensor including: a step of immobilizing a cytochrome c552, a derivative thereof or a variant thereof on a gold electrode; and a step of bonding a fluorescent protein to the cytochrome c552, the derivative thereof or the variant thereof. [0013] Moreover, the present invention provides a photoelectric transducer including: a gold electrode; a cytochrome c552, a derivative thereof or a variant thereof immobilized on the gold electrode; and a fluorescent protein bonded to the cytochrome c552, the derivative thereof or the variant thereof. Further, the present invention provides a method of manufacturing a photoelectric transducer including: a step of immobilizing a cytochrome c552, a derivative thereof or a variant thereof on a gold electrode; and a step of bonding a fluorescent protein to the cytochrome c552, the derivative thereof or the variant thereof. [0014] In the above-described photosensor and the above-described photoelectric transducer formed by immobilizing a cytochrome c552, a derivative thereof or a variant thereof on a gold electrode and bonding a fluorescent protein thereto and a methods of manufacturing them, as the fluorescent protein, a fluorescent protein with a necessary absorption wavelength is used. In particular, in the case where the photosensor is a color photosensor, as the fluorescent protein, a fluorescent protein absorbing red light, a fluorescent protein absorbing green light and a fluorescent protein absorbing blue light are used. Likewise, in a red-light, green-light or blue-light photoelectric transducer, a fluorescent protein absorbing red light, green light or blue light is used. [0015] In the above-described respective inventions, preferably, a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof, or a cytochrome c552 modified zinc-porphyrin, or a cytochrome c552, a derivative thereof or a variant thereof is immobilized with a hydrophobic portion thereof facing the electrode or the gold electrode. Typically, the cytochrome c552, the derivative thereof or the variant thereof, or the cytochrome c552 modified zinc-porphyrin, or the cytochrome c552, the derivative thereof or the variant thereof is bonded to the electrode or the gold electrode with a self-assembled monolayer in between. In this case, a derivative of the zinc-substituted cytochrome c552 is a zinc-substituted cytochrome c552 having a chemically modified amino acid residue or porphyrin in a skeleton thereof. A variant of the zinc-substituted cytochrome c552 is a zinc-substituted cytochrome c552 having a part of an amino acid residue in a skeleton thereof substituted by another amide acid residue. Likewise, a derivative of the cytochrome c552 is a cytochrome c552 having a chemically modified amino acid residue or heme in a skeleton thereof, and a variant of the cytochrome c552 is a cytochrome c552 having a part of an amino acid residue in a skeleton thereof by another amino acid residue. [0016] In the above-described respective inventions, the photoelectric transducer includes a counter electrode in addition to the electrode or the gold electrode on which a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof, or a cytochrome c552 modified zinc-porphyrin, or a cytochrome c552, a derivative thereof or a variant thereof is immobilized. The counter electrode is arranged to face the electrode or the gold electrode with a space in between. Moreover, the present invention provides a photoelectric transducer using a metal-substituted cytochrome c552, a derivative thereof or a variant thereof. Further, the present invention provides a method of manufacturing a photoelectric transducer including: a step of immobilizing a metal-substituted cytochrome c552, a derivative thereof or a variant thereof on an electrode. In these inventions using a metal-substituted cytochrome c552, a derivative thereof or a variant thereof, matters described relative to the above-described respective inventions are established unless it departs from the nature thereof. A metal of the metal-substituted cytochrome c552 is selected as necessary to obtain a target photoelectric conversion wavelength. [0017] In the invention configured as described above, a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof, or a cytochrome c552 modified zinc-porphyrin, or a cytochrome c552, a derivative thereof or a variant thereof, or a metal-substituted cytochrome c552, a derivative thereof or a variant thereof has higher thermal stability than a zinc-substituted cytochrome c, bacteriorhodopsin or the like. In addition, a photoelectric transducer absorbing red light, green light or blue light is allowed to be obtained by a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof, or a cytochrome c552 modified zinc-porphyrin. Moreover, a photoelectric transducer absorbing light with a desired wavelength is allowed to be obtained by a metal-substituted cytochrome c552, a derivative thereof or a variant thereof. [0018] According to the invention, the zinc-substituted cytochrome c552, the cytochrome c552 modified zinc-porphyrin, the cytochrome c552, the metal-substituted cytochrome c552 or the like has high thermal stability; therefore, a color imaging element, a photosensor and a photoelectric transducer which use a protein and are capable of being stably used for a long time are achievable. Then, a superior electronic device is achievable with use of such a superior color imaging element, photosensor or photoelectric transducer. BRIEF DESCRIPTION OF THE DRAWINGS [0019] [FIG. 1] FIG. 1 is a schematic diagram illustrating a blue-light photoelectric transducer according to a first embodiment of the invention. [FIG. 2] FIG. 2 is a schematic diagram illustrating a structure of a zinc-substituted cytochrome c552 used in the blue-light photoelectric transducer according to the first embodiment of the invention. [FIG. 3] FIG. 3 is a schematic diagram illustrating the structure of the zinc-substituted cytochrome c552 used in the blue-light photoelectric transducer according to the first embodiment of the invention. [FIG. 4] FIG. 4 is a schematic diagram illustrating a structure of a horse-heart cytochrome c. [FIG. 5] FIG. 5 is a schematic diagram illustrating the structure of the horse-heart cytochrome c. [FIG. 6] FIG. 6 is a schematic diagram specifically illustrating the structure of the zinc-substituted cytochrome c552 used in the blue-light photoelectric transducer according to the first embodiment of the invention. [FIG. 7] FIG. 7 is a schematic diagram specifically illustrating the structure of the zinc-substituted cytochrome c552 used in the blue-light photoelectric transducer according to the first embodiment of the invention. [FIG. 8] FIG. 8 is a schematic diagram illustrating a structure of a self-assembled monolayer used in the blue-light photoelectric transducer according to the first embodiment of the invention. [FIG. 9] FIG. 9 is a schematic diagram illustrating a first example of usage of the blue-light photoelectric transducer according to the first embodiment of the invention. [FIG. 10] FIG. 10 is a schematic diagram illustrating a second example of usage of the blue-light photoelectric transducer according to the first embodiment of the invention. [FIG. 11] FIG. 11 is a schematic diagram illustrating a third example of usage of the blue-light photoelectric transducer according to the first embodiment of the invention. [FIG. 12] FIG. 12 is a schematic diagram illustrating a measurement result of a circular dichroic spectrum of a zinc-substituted cytochrome c552. [FIG. 13] FIG. 13 is a schematic diagram illustrating measurement results of absorption spectra of various kinds of cytochromes c552. [FIG. 14] FIG. 14 is a schematic diagram illustrating an absorption spectrum of a zinc-substituted cytochrome c and a structure of a zinc-porphyrin as a chromophore of the zinc-substituted cytochrome c. [FIG. 15] FIG. 15 is a schematic diagram illustrating measurement results of absorption spectra and fluorescence spectra of a zinc-substituted cytochrome c552. [FIG. 16] FIG. 16 is a schematic diagram illustrating measurement results of quantum yields of a zinc-substituted cytochrome c552 and a zinc-substituted cytochrome c. [FIG. 17] FIG. 17 is a schematic diagram for describing photolysis of the zinc-substituted cytochrome c552 and the zinc-substituted cytochrome c. [FIG. 18] FIG. 18 is a schematic diagram illustrating an example of fitting of second-order reaction equations of photolysis reactions of a zinc-substituted cytochrome c552 and a zinc-substituted cytochrome c. [FIG. 19] FIG. 19 is a schematic diagram for describing an effect of inhibiting a photolysis reaction of a zinc-substituted cytochrome c552 by removing oxygen and a radial. [FIG. 20] FIG. 20 is a schematic diagram illustrating measurement results of photocurrent action spectra of a zinc-substituted-cytochrome-c552-inrmobilized gold drop electrode. [FIG. 21] FIG. 21 is a schematic diagram illustrating a blue-light photoelectric transducer according to a second embodiment of the invention. [FIG. 22] FIG. 22 is a schematic diagram illustrating results of cyclic voltammetry performed with use of a cytochrome-c552-immobilized electrode. [FIG. 23] FIG. 23 is a schematic diagram illustrating results of cyclic voltammetry performed with use of the cytochrome-c552-immobilized electrode. [FIG. 24] FIG. 24 is a schematic diagram illustrating daily changes in current value when the cytochrome-c552-immobilized electrode is stored in a protein solution at room temperature. [FIG. 25] FIG. 25 is a schematic diagram illustrating results of cyclic voltammetry performed with use of cytochrome-c552-immobilized electrodes. [FIG. 26] FIG. 26 is a schematic diagram illustrating results of cyclic voltammetry performed with use of cytochrome-c552-immobilized electrodes. [FIG. 27] FIG. 27 is a schematic diagram illustrating results of cyclic voltammetry performed with use of cytochrome-c552-immobilized electrodes formed by using cytochrome-c552 solutions with different KC1 concentrations. [FIG. 28] FIG. 28 is a schematic diagram illustrating results of cyclic voltammetry performed with use of cytochrome-c552-immobilized electrodes formed by using different contents of HS(CH3)10CH2OH used for formation of self-assembled monolayers. [FIG. 29] FIG. 29 is a schematic diagram illustrating results of cyclic voltammetry performed with use of cytochrome-c552-immobilized electrodes formed by using different contents of HS(CH3)10CH2OH used for formation of self-assembled monolayers. [FIG. 30] FIG. 30 is a diagram obtained by plotting, with respect to contents of HS(CH3)10CH2OH in materials used for formation of self-assembled monolayers, current values at peaks in cyclic voltammograms obtained by cyclic voltammetry performed with use of cytochrome-c552-immobilized electrodes formed by using different contents of HS(CH3)10CH2OH. [FIG. 31] FIG. 31 is a schematic diagram illustrating results of cyclic voltammetry performed with use of cytochrome-c552-immobilized electrodes formed by using hydrophobic thiols and hydrophilic thiols with different lengths used for formation of self-assembled monolayers. [FIG. 32] FIG. 32 is a schematic diagram illustrating a green-light or red-light photoelectric transducer according to a third embodiment of the invention. [FIG. 33] FIG. 33 is a schematic diagram illustrating a method of synthesizing a cytochrome c552 modified zinc-porphyrin. [FIG. 34] FIG. 34 is a schematic diagram illustrating a protoporphyrin. [FIG. 35] FIG. 25 is a schematic diagram illustrating 2,4-diacetyldeuteroporphyrin. [FIG. 36] FIG. 26 is a schematic diagram illustrating a diformyldeuteroporphyrin. [FIG. 37] FIG. 37 is a schematic diagram illustrating a mesotetrachlorooctaethylporphyrin. [FIG. 38] FIG. 38 is a schematic diagram illustrating a measurement result of an absorption spectrum of a mesotetrachlorooctaethylporphyrin. [FIG. 39] FIG. 39 is a schematic diagram illustrating a mesotetrachloroporphyrin. [FIG. 40] FIG. 40 is a schematic diagram illustrating bilirubin obtained by opening a protoporphyrin ring at the a-position thereof and adding oxygen atoms. [FIG. 41] FIG. 41 is a schematic diagram illustrating measurement results of spectral changes of bilirubin in zinc titration. [FIG. 42] FIG. 42 is a schematic diagram illustrating a tetraazaporphyrin. [FIG. 43] FIG. 43 is a schematic diagram illustrating measurement results of absorption spectra of tetraazaporphyrins. [FIG. 44] FIG. 44 is a schematic diagram illustrating a tetraazaporphyrin formed by adding vinyl groups to the 2- and 4-positions thereof and adding propionic acid groups to the 6- and 7-positions thereof. [FIG. 45] FIG. 45 is a schematic diagram illustrating absorption spectra of freebase octaethylporphyrin and vanadyl octaethylporphyrin. [FIG. 46] FIG. 46 is a schematic diagram illustrating absorption spectra of nickel octaethylporphyrin and zinc octaethylporphyrin. [FIG. 47] FIG. 47 is a schematic diagram illustrating absorption spectra of magnesium etioporphyrin-I and cobalt octaethylporphyrin. [FIG. 48] FIG. 48 is a schematic diagram illustrating absorption spectra of copper octaethylporphyrin and palladium octaethylporphyrin. [FIG. 49] FIG. 49 is a schematic diagram illustrating an octaethylporphyrin. [FIG. 50] FIG. 50 is a schematic diagram illustrating an etioporphyrin. [FIG. 51] FIG. 51 is a schematic diagram illustrating a green-light or red-light photoelectric transducer according to a fourth embodiment of the invention. [FIG. 52] FIG. 52 is a schematic diagram illustrating a first example of a color imaging element according to a fifth embodiment of the invention. [FIG. 53] FIG. 53 is a schematic diagram illustrating a second example of the color imaging element according to the fifth embodiment of the invention. [FIG. 54] FIG. 54 is a circuit diagram illustrating a photosensor according to a seventh embodiment of the invention. [FIG. 55] FIG. 55 is a plan view illustrating a configuration example of the photosensor according to the seventh embodiment of the invention. [FIG. 56] FIG. 56 is a sectional view illustrating a configuration example of the photosensor according to the seventh embodiment of the invention. [FIG. 57] FIG. 57 is a sectional view illustrating a configuration example of the photosensor according to the seventh embodiment of the invention. [FIG. 58] FIG. 58 is a sectional view illustrating a color CCD imaging element according to an eighth embodiment of the invention. [FIG. 59] FIG. 59 is a circuit diagram illustrating an inverter circuit according to a ninth embodiment of the invention. [FIG. 60] FIG. 60 is a circuit diagram illustrating a configuration example of the inverter circuit according to the ninth embodiment of the invention. [FIG. 61] FIG. 61 is a schematic diagram illustrating a photosensor according to a tenth embodiment of the invention. [FIG. 62] FIG. 62 is a sectional view illustrating the photosensor according to the tenth embodiment of the invention. [FIG. 63] FIG. 63 is a circuit diagram illustrating the photosensor according to the tenth embodiment of the invention. DESCRIPTION OF EMBODIMENTS [0020] Best modes for carrying out the invention (hereinafter referred to as "embodiments") will be described below referring to the accompanying drawings. It is to be noted that descriptions will be given in the following order. 1. First Embodiment (Blue-light photoelectric transducer) 2. Second Embodiment (Blue-light photoelectric transducer) 3. Third Embodiment (green-light or red-light photoelectric transducer) 4. Fourth Embodiment (Green-light or red-light photoelectric transducer) 5. Fifth Embodiment (Color imaging element) 6. Sixth Embodiment (Photosensor) 7. Seventh Embodiment (Photosensor) 8. Eighth Embodiment (Color CCD imaging element) 9. Ninth Embodiment (Inverter circuit) 10. Tenth Embodiment (photosensor) [0021] (1. First Embodiment) [Blue-light photoelectric transducer] A cytochrome c552 derived from a thermophile, Thermus thermophilus serves as an electron carrier in vivo as in the case of a horse-heart cytochrome c. Although active centers of the cytochrome c552 and the horse-heart cytochrome c similarly contain a heme (an iron-protoporphyrin DC complex), the cytochrome c552 has extremely high thermal stability by an amino acid around the active center thereof which is different from that in the horse-heart cytochrome c (refer to NPTL 1). For example, whereas a typical protein and the horse-heart cytochrome c have a denaturation midpoint of 50°C to 60°C and a denaturation midpoint of 85°C, respectively, the cytochrome c552 has a higher denaturation midpoint of not less than 100°C, because the denaturation temperature of the cytochrome c552 is not measurable in a typical aqueous solution (of which the upper temperature limit is 100°C). In addition, it is reported that the cytochrome c552 has a denaturation midpoint of 60°C to 70°C in the presence of 4.2 M guanidine hydrochloride (a denaturant). [0022] A zinc-substituted cytochrome c552 formed by substituting zinc for iron as the central metal of the heme of a cytochrome c552 has as high thermal stability as the cytochrome c552, and is a fluorescent protein absorbing blue light. Therefore, in the first embodiment, the zinc-substituted cytochrome c552 is used for a blue-light photoelectric transducer. [0023] FIG. 1 illustrates the blue-light photoelectric transducer according to the first embodiment, and in particular, a protein-immobilized electrode. As illustrated in FIG. 1, in the blue-light photoelectric transducer, a zinc-substituted cytochrome c552 13 is immobilized on a gold electrode 11 with a self-assembled monolayer (SAM) 12 in between. In this case, the cytochrome c552 13 is immobilized with a hydrophobic portion 13a thereof facing the gold electrode 11. Zinc (Zn) as a central metal is coordinated to a porphyrin 13b inside the zinc-substituted cytochrome c552 13. [0024] FIG. 2A schematically illustrates a structure of a zinc-substituted cytochrome c552. FIG. 2A illustrates a porphyrin, axial ligands thereof, i.e., histidine (His) and methionine (Met), and a lysine residue (a positively charged amino acid) of the zinc-substituted cytochrome c552 represented by stick models. FIG. 2A is a front view of the porphyrin, where a direction in which the axial ligand, histidine (His) is located on a right side is regarded as front. FIG. 2B illustrates a surface charge distribution diagram of the zinc-substituted cytochrome c552 illustrated in FIG. 2A. FIG. 3A illustrates a diagram of the zinc-substituted cytochrome c552 viewed from a back side of the porphyrin. FIG. 3B illustrates a surface charge distribution diagram of the zinc-substituted cytochrome c552 illustrated in FIG. 3 A. [0025] For comparison, FIG. 4A illustrates a diagram of a horse-heart cytochrome c viewed from a front side of the heme thereof, FIG. 4B illustrates a surface charge distribution diagram of the horse-heart cytochrome c illustrated in FIG. 4A, FIG. 5 A illustrates a diagram of the horse-heart cytochrome c viewed from a back side of the heme thererof, and FIG. 5B illustrates a surface charge distribution diagram of the horse-heart cytochrome c illustrated in FIG. 5A. [0026] While, as illustrated in FIGs. 4B and 5B, the horse-heart cytochrome c has positive charges dispersed over an entire molecule thereof, as illustrated in FIGs. 2B and 3B, the zinc-substituted cytochrome c552 has positive charges concentrated on the back side of the porphyrin. Moreover, the front side of the porphyrin of the zinc-substituted cytochrome c552 13 is occupied by hydrophobic residues and neutral polar residues. The hydrophobic portion 13a of the zinc-substituted cytochrome c552 13 refers to a front portion of the porphyrin. [0027] FIG. 6 schematically illustrates the zinc-substituted cytochrome c552 13 immobilized on the gold electrode 11 with the self-assembled monolayer 12 in between. In FIG. 6, the axial ligand, histidine is located on a front side of the zinc-substituted cytochrome c552 13, and a lysine residue is represented by a stick model. FIG. 7 illustrates a diagram of the zinc-substituted cytochrome c552 13 immobilized on the gold electrode 11 with the self-assembled monolayer 12 in between viewed from the gold electrode 11 side, where the axial ligand, histidine is located on a right side (in front of the porphyrin). In FIG. 7, an amino acid side chain is represented by a stick model. [0028] The self-assembled monolayer 12 is configured of three portions. A first portion is a bonding functional group (for example, a thiol group (-SH) or the like) reacting with an atom on a surface of the gold electrode 11 on which the self-assembled monolayer 12 is to be immobilized. A second portion is typically an alkyl chain, and a two-dimensional ordered structure of the self-assembled monolayer 12 is determined mainly by a Van der Waals'' force between the alkyl chains. Therefore, typically, in the case where the alkyl chain has a certain number or more of carbon atoms, a stable, highly dense and highly oriented film is formed. A third portion is an end group, and when the end group is a functional group with functionality, a solid surface is allowed to be functionalized. [0029] The self-assembled monolayer 12 is formed with use of, for example, a hydrophobic thiol and a hydrophilic thiol, and the proportions of the hydrophobic thiol and the hydrophilic thiol determine ease of bonding between the zinc-substituted cytochrome c552 13 and the gold electrode 11. Examples of a hydrophilic group of the hydrophilic thiol include -OH, -NH2, SO3", OSO3", COO", NlV and the like The hydrophobic thiol and the hydrophilic thiol are selected as necessary. [0030] As a preferable example of a combination of the hydrophobic thiol and the hydrophilic thiol, the hydrophobic thiol is HS(CH2)nCH3 (n=5, 8 or 10), and the hydrophilic thiol is HS(CH2)nCH2OH (n=5, 8 or 10). More specifically, for example, the hydrophobic thiol is 1-undecane thiol (HS(CH2)10CH3) and the hydrophilic thiol is 1-hydroxy-11-undecane thiol (HS(CH2)10CH2OH). As another example of the combination of the hydrophobic thiol and the hydrophilic thiol, the hydrophobic thiol is HS(CH2)mCH3, and the hydrophilic thiol is HS(CH2)nCH2OH (where m2 film may be formed on a surface of the substrate 61, and the gold electrodes 62a, 62b and 62c may be formed thereon. [0105] In a section corresponding to the red-light photoelectric transducer, as in the case of the red-light photoelectric transducer according to the third embodiment, for example, a cytochrome c552 modified zinc-porphyrin 64 absorbing red light is immobilized on the gold electrode 62a with a self-assembled monolayer 63 a in between. Moreover, in a section corresponding to the green-light photoelectric transducer, as in the case of the green-light photoelectric transducer according to the third embodiment, for example, a cytochrome c552 modified zinc-porphyrin 65 absorbing green light is immobilized on the gold electrode 62b with a self-assembled monolayer 63b in between. Further, in a section corresponding to the blue-light photoelectric transducer, as in the case of the blue-light photoelectric transducer according to the first embodiment, a zinc-substituted cytochrome c552 66 is immobilized on the gold electrode 62c with a self-assembled monolayer 63 c in between. [0106] As the red-light, green-light and blue-light photoelectric transducers, the same photoelectric transducers as those according to the second or fourth embodiment may be used. In other words, as illustrated in FIG. 53, in the section corresponding to the red-light photoelectric transducer, a cytochrome c552 67 is immobilized on the gold electrode 62a with the self-assembled monolayer 63 a in between, and a fluorescent protein 68 absorbing red light is electrostatically bonded to the cytochrome c552 67. As this fluorescent protein 68, commercially available fluorescent proteins, a cytochrome c552 modified zinc-porphyrin and the like are allowed to be used. Moreover, in the section corresponding to the green-light photoelectric transducer, a cytochrome c552 69 is immobilized on the gold electrode 62b with the self-assembled monolayer 63b in between, and a fluorescent protein 70 absorbing green light is electrostatically bonded to the cytochrome c552 69. As this fluorescent protein 70, for example, commercially available fluorescent proteins, a cytochrome c552 modified zinc-porphyrin and the like are allowed to be used. Further, in the section corresponding to the blue-light photoelectric transducer, a cytochrome c552 71 is immobilized on the gold electrode 62c with the self-assembled monolayer 63c in between, and a fluorescent protein absorbing blue light, for example, a zinc-substituted cytochrome c552 or a commercially available fluorescent protein is electrostatically bonded to the cytochrome c552 71. [0107] As the red-light, green-light and blue-light photoelectric transducers, photoelectric transducers similar to those according to the first to fourth embodiments may be used together. The arrangement of red-light, green-light, and blue-light photoelectric transducers on the substrate 61 is similar to that in, for example, a known CCD color imaging element or a known MOS color imaging element in related art, and is determined as necessary In other points, the fifth embodiment is similar to the first embodiment. According to the fifth embodiment, a novel color imaging element which uses a protein and is capable of being stably used for a long time is achievable. [0108] (6. Sixth Embodiment) [Photosensor] In a photosensor according to a sixth embodiment, a photoelectric transducer which uses a fluorescent protein and has an absorption wavelength corresponding to the wavelength of light to be detected is used. In particular, in the case where this photosensor is a color photosensor, a red-light photoelectric transducer, a green-light photoelectric transducer and a blue-light photoelectric transducer are used. As these photoelectric transducer, in the case where red light, green light or blue light is to be detected, the red-light, green-light or blue-light photoelectric transducer according to the first to fourth embodiments is allowed to be used. Alternatively, in the case where light with a wavelength other than red light, green light or blue light is to be detected, a photoelectric transducer using a cytochrome c552 modified zinc-porphyrin whose absorption wavelength is adjusted to the wavelength is used. These photoelectric transducers may be formed on one and the same substrate, or the photoelectric transducers may be formed on a plurality of substrates, respectively, to constitute a photosensor by arranging these substrates. The arrangement of the photoelectric transducers on the substrate is determined as necessary; however, in the color photosensor, the photoelectric transducers are allowed to be arranged in the same manner as that in, for example, a known CCD color imaging element or a known MOS color imaging element in related art. In other points, the sixth embodiment is similar to the first embodiment. According to the sixth embodiment, a novel photosensor which uses a protein and is capable of being stably used for a long time is achievable. [0109] (7. Seventh Embodiment) [Photosensor] FIG. 54 is a circuit diagram illustrating a photosensor according to a seventh embodiment. As illustrated in FIG. 54, this photosensor is configured of a photodiode 71 which is configured of the photoelectric transducer according to one of the first to fourth embodiments and a single-electron transistor 72 for amplifying an output of the photodiode 71. The single-electron transistor 72 is configured of a small tunnel junction J1 on a drain side and a small tunnel junction J2 on a source side. The capacitances of the small tunnel junctions J1 and J2 are represented by C1 and C2, respectively. For example, while one electrode of the photodiode 71 is grounded through a load resistor RL, the other electrode thereof is connected to a positive power supply for supplying a positive voltage VPD for biasing the photodiode 72. On the other hand, while a source of the single-electron transistor 72 is grounded, a drain thereof is connected to a positive power supply for supplying a positive voltage Vcc through an output resistor Rout- Then, the electrode on the load resistor RL side of the photodiode 71 and a gate of the single-electron transistor 72 are connected to each other through a capacitor Cg. [0110] In the photosensor configured as described above, when the photodiode 71 is irradiated with light to allow a photocurrent to flow, a voltage generated across both ends of the load resistor RL charges the capacitor Cg, and a gate voltage Vg is applied to the gate of the single-electron transistor 72 through the capacitor Cg. Then, a change ΔVg in the gate voltage Vg is measured by measuring a change ΔQ=CgΔVg in the amount of charge accumulated in the capacitor Cg. In this case, the single-electron transistor 72 used for amplifying the output of the photodiode 71 is allowed to measure the change ΔQ=CgΔVg in the amount of charge accumulated in the capacitor Cg with, for example, a million times as high sensitivity as that of a transistor in related art. In other words, as the single-electron transistor 72 is allowed to measure a slight change ΔVg in the gate voltage Vg, the value of the load resistor RL is allowed to be reduced. Therefore, much higher sensitivity and much higher speed of the photosensor are achievable. Moreover, thermal noise is suppressed on the single-electron transistor 72 side by a charging effect; therefore, noise generated on an amplifier circuit side is allowed to be suppressed. In addition, the single-electron transistor 72 has extremely low power consumption, because the single-electron transistor 72 uses a single-electron tunneling effect in its basic operation. In this photosensor, as described above, the photodiode 71 and the single-electron transistor 72 are capacitively coupled. As a voltage gain at this time is given by Cg/C1, an output voltage Vout high enough to drive an element connected to a subsequent stage of the photosensor is allowed to be easily obtained by reducing the capacitance C1 of the small tunnel junction Jl to a sufficiently low value. [0111] Next, a specific configuration example of the photosensor will be described below. In this example, the single-electron transistor 72 is configured by a metal-insulator junction, and the photodiode 71 is configured of the photoelectric transducer according to one of the first to fourth embodiments. FIG. 55 is a plan view of the photosensor. FIG. 56 is a sectional view of the photodiode 71 in the photosensor, and FIG. 57 is a sectional view of the single-electron transistor 72 in the photosensor. [0112] As illustrated in FIGs. 55, 56 and 57, in this photosensor, an insulating film 82 such as an SiO2 film, an SiN film or a polyimide film is arranged on a substrate 81 such as a semiconductor substrate. In a portion corresponding to the photodiode 71 of the insulating film 82, an opening 82a is provided. Then, a gold electrode 83 is arranged on the substrate 81 in the opening 82a, and a fluorescent protein 84 having an absorption wavelength corresponding to the wavelength of light to be detected is immobilized on the gold electrode 83, and a counter electrode 85 is arranged thereon with a solid electrolyte (not illustrated) in between. In this case, light passes through the counter electrode 85 to be received; therefore, the counter electrode 85 is transparent to light used for photoexcitation of the fluorescent protein 84. As the fluorescent protein 84, for example, fluorescent proteins similar to those used in the photoelectric transducers according to the first to fourth embodiments are allowed to be used. [0113] On the other hand, a source electrode 86 and a drain electrode 87 are arranged in a portion corresponding to the single-electron transistor 72 of the insulating film 82 to face each other. Then, a gate electrode 88 is formed to partially overlap an end of the source electrode 86 and an end of the drain electrode 87. In this case, insulating films 89 with a thickness of, for example, several tenths of a nanometer to several nanometers are formed on surfaces of at least portions overlapping the gate electrode 88 of the source electrode 86 and the drain electrode 87. Thus, the gate electrode 88 partially overlaps the ends of the source electrode 86 and the drain electrode 87 with the insulating films 89 in between. The overlapping portions typically have a size of several hundreds of nanometers by several hundreds of nanometers, or less. In this case, the portions where the gate electrode 88 overlaps the source electrode 86 with the insulating films 89 in between correspond to the small tunnel junction J1 and J2, respectively in FIGs. 54 and 55. The gate electrode 88, the source electrode 86, and the drain electrode 87 are formed of, for example, a metal such as Al, In, Nb, Au or Pt A passivation film (not illustrated) is optionally arranged on an entire surface to cover the photodiode 71 and the single-electron transistor 72 therewith. [0114] In this case, an end of the counter electrode 85 of the photodiode 71 is adjacent to the gate electrode 88 of the single-electron transistor 72. Then, in the case where no passivation film is provided, a capacitor is formed between the end of the counter electrode 85 and the gate electrode 88 with an air layer in between, thereby capacitively coupling the counter electrode 85 and the gate electrode 88. In the case where a passivation film is provided, a capacitor is formed between the end of the counter electrode 85 and the gate electrode 88 with the passivation film in between, thereby capacitively coupling the counter electrode 85 and the gate electrode 88. Thus, according to the seventh embodiment, a novel photosensor which uses a protein and is capable of being stably used for a long time is achievable. Moreover, this photosensor is configured to amplify the output of the photodiode 71 by the single-electron transistor 72. Therefore, the photosensor is allowed to have much higher speed, higher sensitivity and lower power consumption than a typical photosensor in related art which amplifies the output of the photodiode by a typical transistor in related art. [0115] (8. Eighth Embodiment) [Color CCD imaging element] Next, a color CCD imaging element according to an eighth embodiment will be described below. This color CCD imaging element is an interline-transfer type CCD imaging element including a light-sensitive section, a vertical register, and a horizontal register. FIG. 58 illustrates a sectional structure of the light-sensitive section and the vertical register in proximity to the light-sensitive section of the color CCD imaging element. As illustrated in FIG. 58, a gate-insulating film 92 is formed on a p-type sihcon substrate 91 (or on a p-well layer formed on an n-type silicon substrate), and a read-out gate electrode 93 is formed on the gate-insulating film 92. An n-type layer 94 and an n-type layer 95 constituting the vertical register are formed in the p-type silicon substrate 91 on both sides of the read-out gate electrode 93. An opening 92a is formed in the gate-insulating film 92 above the n-type layer 94. Then, a gold electrode 95 is arranged on the n-type layer 94 in the opening 92a, and a fluorescent protein 96 similar to that used in the photoelectric transducer according to any one of the first to fourth embodiments is immobilized on the gold electrode 95, and a counter electrode 97 is arranged thereon with a solid electrolyte (not illustrated) in between. The photoelectric transducer constitutes a light-sensitive section 98. In this case, as light passes through the counter electrode 97 to be received, the counter electrode 97 is transparent to light used for photoexcitation of the electron transfer protein 96. The other configuration of the color CCD imaging element (including the arrangement of red, green, and blue light-sensitive elements 98) is similar to that of a known interline-transfer type color CCD imaging element in related art. [0116] In the color CCD imaging element, the gold electrode 95 of the photoelectric transducer constituting the light-sensitive element 98 is positively biased relative to the counter electrode 97. When light enters the fluorescent protein 96 in the light-sensitive element 98, electrons generated by photoexcitation flow into the n-type layer 94. Next, in a state where a voltage higher than that of the n-type layer 94 is applied to the n-type layer 95 constituting the vertical register, a positive voltage is applied to the read-out gate electrode 93 to form an n-type channel in the p-type silicon substrate 91 directly under the read-out gate electrode 93, and electrons of the n-type layer 94 are read to the n-type layer 95 through the n-type channel. After that, a charge read out in such a manner is transferred through the vertical register and then through the horizontal register, thereby extracting an electrical signal corresponding to an image picked up from an output terminal. According to the eighth embodiment, a novel color CCD imaging element which uses the fluorescent protein 96 for the light-sensitive section 98 and is capable of being stably used for a long time is achievable. [0117] (9. Ninth Embodiment) [Inverter circuit] Next, an inverter circuit according to a ninth embodiment of the invention will be described below. FIG. 59 illustrates the inverter circuit. As illustrated in FIG. 59, in this inverter circuit, a photoelectric transducer 101 with the same configuration as that of one of the first to fourth embodiments and a load resistor RL are connected to each other in series. In this case, the load resistor RL is connected to a counter electrode (not illustrated) of the photoelectric transducer 101. A predetermined positive power supply voltage VDD is applied to an end of the load resistor RL, and a gold electrode of the photoelectric transducer 101 is grounded. When a fluorescent protein (not illustrated) of the photoelectric transducer 101 is irradiated with light having an absorption wavelength of the fluorescent protein as signal light, the photoelectric transducer 101 is turned on to allow a photocurrent to flow therethrough, thereby setting an output voltage Vout from the gold electrode (not illustrated) to a low level, and when irradiation with the light stops, the photoelectric transducer 101 is turned off to allow the photocurrent not to flow therethrough, thereby setting the output voltage Vout from the gold electrode to a high level. [0118] FIG. 60 illustrates a configuration example of the inverter circuit. As illustrated in FIG. 60, in this configuration example, an n-type layer 112 used as the load resistor RL is formed in a p-type silicon substrate 111 (or in a p-well layer formed in an n-type silicon substrate). An insulating film 113 such as a SiO2 film is formed on a surface of the p-type silicon substrate 111. Openings 113a and 113b are formed in the insulating film 113 at one end and the other end of the n-type layer 112. A gold electrode 114 is arranged on the n-type layer 112 in the opening 113a, and a fluorescent protein 115 similar to that used in the photoelectric transducer according to any one of the first to fourth embodiments is immobilized on the gold electrode 114, and a counter electrode 115 is arranged thereon with a solid electrolyte (not illustrated) in between. The gold electrode 114, the fluorescent protein 115, the solid electrolyte and the counter electrode 116 constitute a photoelectric transducer 117. The electrode 118 is in ohmic contact with the n-type layer 112 through the opening 113b. In addition to the above-described inverter circuit, various electronic circuits (such as an amplifier circuit) driven by the output voltage Vout are allowed to be optionally formed on the p-type silicon substrate 111. According to the ninth embodiment, a novel inverter circuit which uses a protein and is capable of being stably used for a long time is allowed to be configured, and various circuits such as logic circuits are allowed to be configured with use of the inverter circuit. [0119] (10. Tenth Embodiment) [Photosensor] FIG. 61 illustrates a photosensor according to a tenth embodiment of the invention. As illustrated in FIG. 61, this photosensor includes light-sensitive sections 122, which are configured of photoelectric transducers similar to those according to the first to fourth embodiments, arranged on a silicon substrate 121 in a two-dimensional matrix form. The silicon substrate 121 is an integrated circuit including circuits necessary for photosensor, such as a signal-processing circuit and a drive circuit. [0120] FIG. 62 illustrates a specific configuration of each light-sensitive element 122. As illustrated in FIG. 62, an insulating film 123 such as a SiO2 film is formed on, for example, a p-type silicon substrate 121. A recess 124 having a predetermined planar shape, for example, a square planar shape is formed on a top of the insulating film 123. A contact hole 125 having a predetermined planar shape, for example, a circular planar shape is formed in a center portion of the recess 124. A gold electrode 126 is formed on a bottom surface of the recess 124. The gold electrode 126 is also formed in the contact hole 125. A fluorescent protein 127 used in the photoelectric transducer according to any one of the first to fourth embodiments is immobilized on the gold electrode 126 with a self-assembled monolayer (not illustrated) in between. A solid electrolyte layer 128 is arranged on the fluorescent protein 127. Then, a counter electrode 129 is arranged on the solid electrolyte layer 128. The gold electrode 126, the fluorescent protein 127, the solid electrolyte layer 128 and the counter electrode 129 constitute a photoelectric transducer. The photoelectric transducer constitutes the light-sensitive section 122. [0121] An n-channel MOSFET 133 configured of a gate electrode 130 formed with a gate-insulating film in between, an n-type source region 131, and an n-type drain region 132 is formed on the p-type silicon substrate 121. The gold electrode 126 is in contact with the drain region 132 of the n-channel MOSFET 133 through the contact hole 125. Moreover, an n-channel MOSFET 137 configured of a gate electrode 134 formed with the gate-insulating film therebetween, an n-type source region 135 and an n-type drain region 136 is formed on the p-type silicon substrate 121. An end of a counter electrode 129 extends to the top of the insulating film 123 outside the recess 124, and the extending portion of the counter electrode 129 is in contact with the drain region 136 of the n-channel MOSFET 137 through a metal 139 embedded in a contact hole 138 formed in the insulating film 123. The source region 131 of the n-channel MOSFET 133 and the gate electrode 134 and the source region 135 of the n-channel MOSFET 137 are connected to a column-selection/current-detection circuit 140. [0122] FIG. 63 illustrates an example of a circuit configuration of the photosensor. As illustrated in FIG. 63, a row-selection circuit 141 and the column-selection/current-detection circuit 140 select the light-sensitive elements 122 arranged on the silicon substrate 121 in a two-dimensional matrix form and detect a photocurrent obtained from the light-sensitive elements 122. The row-selection circuit 141 and the column-selection/current-detection circuit 140 are allowed to be configured in the same manner as that of a known semiconductor memory in related. According to the tenth embodiment, a novel photosensor which uses a fluorescent protein for the light-sensitive section 122 and is capable of being stably used for a long time is achievable. [0123] Although the embodiments of the present invention have been specifically described above, the invention is not limited thereto and may be variously modified based on the technical ideas of the invention. For example, the values, structures, configurations, shapes, materials and the like used in the above-described embodiments are merely illustrative, and different values, structures, configurations, shapes, materials and the like may be used as necessary. CLAIMS 1. A color imaging element comprising: a blue-light photoelectric transducer using a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof. 2. The color imaging element according to claim 1, wherein the zinc-substituted cytochrome c552, the derivative thereof or the variant thereof is immobilized on an electrode. 3. The color imaging element according to claim 2, wherein the electrode is a gold electrode. 4. The color imaging element according to claim 3, wherein the zinc-substituted cytochrome c552, the derivative thereof or the variant thereof is immobilized with a hydrophobic portion thereof facing the gold electrode. 5. The color imaging element according to claim 1, comprising: a red-light or green-light photoelectric transducer using a cytochrome c552 modified zinc-porphyrin. 6. A method of manufacturing a color imaging element comprising: a step of immobilizing a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof on an electrode. 7. A photosensor comprising: a blue-light photoelectric transducer using a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof. 8. A method of manufacturing a photosensor comprising: a step of immobilizing a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof on an electrode. 9. A blue-light photoelectric transducer using a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof. 10. A method of manufacturing a blue-light photoelectric transducer comprising: a step of immobilizing a zinc-substituted cytochrome c552, a derivative thereof or a variant thereof on an electrode. 11. A red-light or green-light photoelectric transducer using a cytochrome c552 modified zinc-porphyrin. 12. A method of manufacturing a red-light or green-light photoelectric transducer comprising: a step of immobilizing a cytochrome c552 modified zinc-porphyrin on an electrode. 13. A color imaging element including a red-light, green-light or blue-light photoelectric transducer, the red-light, green-light or blue-light photoelectric transducer comprising: a gold electrode; a cytochrome c552, a derivative thereof or a variant thereof immobilized on the gold electrode; and a fluorescent protein bonded to the cytochrome c552, the derivative thereof or the variant thereof and absorbing red light, green light or blue light. 14. A method of manufacturing a color imaging element comprising: a step of immobilizing a cytochrome c552, a derivative thereof or a variant thereof on a gold electrode; and a step of bonding a fluorescent protein absorbing red light, green light or blue light to the cytochrome c552, the derivative thereof or the variant thereof. 15. A photosensor including a photoelectric transducer, the photoelectric transducer comprising: a gold electrode; a cytochrome c552, a derivative thereof or a variant thereof immobilized on the gold electrode; and a fluorescent protein bonded to the cytochrome c552, the derivative thereof or the variant thereof. 16. A method of manufacturing a photosensor comprising: a step of immobilizing a cytochrome c552, a derivative thereof or a variant thereof on a gold electrode; and a step of bonding a fluorescent protein to the cytochrome c552, the derivative thereof or the variant thereof. 17. A photoelectric transducer comprising: a gold electrode; a cytochrome c552, a derivative thereof or a variant thereof immobilized on the gold electrode; and a fluorescent protein bonded to the cytochrome c552, the derivative thereof or the variant thereof. 18. A method of manufacturing a photoelectric transducer comprising: a step of immobilizing a cytochrome c552, a derivative thereof or a variant thereof on a gold electrode; and a step of bonding a fluorescent protein to the cytochrome c552, the derivative thereof or the variant thereof. 19. A photoelectric transducer using a metal-substituted cytochrome c552, a derivative thereof or a variant thereof. 20. A method of manufacturing a photoelectric transducer comprising: a step of immobilizing a metal-substituted cytochrome c552, a derivative thereof or a variant thereof on an electrode.

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