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A Kit Comprising: I) A Composition Of Mesenchymal Stromal Cells, And Ii) Hyaluronic Acid And Treatment Of Osteoarthritis Thereof
Abstract: The present disclosure relates to an ultrasound guided intraarticular administration of a combination of a composition comprising pooled mesenchymal stromal cells, and mid molecular weight hyaluronic acid for treatment of osteoarthritis. The disclosure also provides methods for increasing levels of anti-inflammatory marker and decreasing levels of disease progression marker in a human subject suffering from osteoarthritis through the use of the said combination. The present disclosure accordingly also relates to a kit comprising the said composition and the hyaluronic acid as such for the said use and treatment.
Notices, Deadlines & Correspondence
Patent Information
Applicants
STEMPEUTICS RESEARCH PRIVATE LIMITED
Inventors
1. PAWAN KUMAR GUPTA
2. UDAYKUMAR KOLKUNDKAR
3. SHIVASHANKAR PARASHURAM
4. SURESH KANNAN SUBRAMANIAN SHANMUGAM
Specification
We claim:
1. A combination product or a kit, comprising a combination of:
• a composition comprising about 20 to 30 million mesenchymal stromal cells,
5 about 1 ml of multiple electrolyte solution and about 1 ml of protein free, serum
free, animal component free formulation of about 2.5% to 5% dimethyl
sulfoxide (DMSO); and
• about 2 ml of mid molecular weight hyaluronic acid,
wherein the composition is devoid of human serum albumin (HSA); and wherein the
mesenchymal stromal cells are bone marrow derived pooled mesenchymal stromal cells
obtained from pooling mesenchymal stromal cells from at least 3 donors.
2. The product or the kit as claimed in claim 1, wherein the multiple electrolyte solution
is Plasmalyte A.
3. The product or the kit as claimed in claim 1, wherein the composition comprises 25
million pooled mesenchymal stromal cells.
4. The product or the kit as claimed in claim 1, wherein the combination is employed for
treatment of Grade II or Grade III osteoarthritis.
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202241070687-STATEMENT OF UNDERTAKING (FORM 3) [07-12-2022(online)].pdf | 2022-12-07 |
| 2 | 202241070687-REQUEST FOR EXAMINATION (FORM-18) [07-12-2022(online)].pdf | 2022-12-07 |
| 3 | 202241070687-REQUEST FOR EARLY PUBLICATION(FORM-9) [07-12-2022(online)].pdf | 2022-12-07 |
| 4 | 202241070687-POWER OF AUTHORITY [07-12-2022(online)].pdf | 2022-12-07 |
| 5 | 202241070687-FORM-9 [07-12-2022(online)].pdf | 2022-12-07 |
| 6 | 202241070687-FORM FOR SMALL ENTITY(FORM-28) [07-12-2022(online)].pdf | 2022-12-07 |
| 7 | 202241070687-FORM FOR SMALL ENTITY [07-12-2022(online)].pdf | 2022-12-07 |
| 8 | 202241070687-FORM 18 [07-12-2022(online)].pdf | 2022-12-07 |
| 9 | 202241070687-FORM 1 [07-12-2022(online)].pdf | 2022-12-07 |
| 10 | 202241070687-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [07-12-2022(online)].pdf | 2022-12-07 |
| 11 | 202241070687-DRAWINGS [07-12-2022(online)].pdf | 2022-12-07 |
| 12 | 202241070687-DECLARATION OF INVENTORSHIP (FORM 5) [07-12-2022(online)].pdf | 2022-12-07 |
| 13 | 202241070687-COMPLETE SPECIFICATION [07-12-2022(online)].pdf | 2022-12-07 |
| 14 | 202241070687-Power of Attorney [11-01-2023(online)].pdf | 2023-01-11 |
| 15 | 202241070687-Form 1 (Submitted on date of filing) [11-01-2023(online)].pdf | 2023-01-11 |
| 16 | 202241070687-Covering Letter [11-01-2023(online)].pdf | 2023-01-11 |
| 17 | 202241070687-Proof of Right [18-01-2023(online)].pdf | 2023-01-18 |
| 18 | 202241070687-MSME CERTIFICATE [19-01-2023(online)].pdf | 2023-01-19 |
| 19 | 202241070687-FORM28 [19-01-2023(online)].pdf | 2023-01-19 |
| 20 | 202241070687-FORM 18A [19-01-2023(online)].pdf | 2023-01-19 |
| 21 | 202241070687-FER.pdf | 2023-02-07 |
| 22 | 202241070687-FORM 3 [12-04-2023(online)].pdf | 2023-04-12 |
| 23 | 202241070687-OTHERS [06-07-2023(online)].pdf | 2023-07-06 |
| 24 | 202241070687-FER_SER_REPLY [06-07-2023(online)].pdf | 2023-07-06 |
| 25 | 202241070687-CLAIMS [06-07-2023(online)].pdf | 2023-07-06 |
| 26 | 202241070687-US(14)-HearingNotice-(HearingDate-18-12-2023).pdf | 2023-12-06 |
| 27 | 202241070687-US(14)-ExtendedHearingNotice-(HearingDate-27-12-2023).pdf | 2023-12-14 |
| 28 | 202241070687-Correspondence to notify the Controller [26-12-2023(online)].pdf | 2023-12-26 |
| 29 | 202241070687-Written submissions and relevant documents [03-01-2024(online)].pdf | 2024-01-03 |
| 30 | 202241070687-PatentCertificate05-01-2024.pdf | 2024-01-05 |
| 31 | 202241070687-IntimationOfGrant05-01-2024.pdf | 2024-01-05 |
Search Strategy
| 1 | SearchHistoryE_07-02-2023.pdf |