Abstract: The present disclosure provides a composition comprising Andrographis paniculata extract, and Vitis vinifera L. extract, obtained from various plant parts, which at particular w/w ratios is particularly useful in reduction of intracellular cholesterol levels. This finds potential application in nature based medicaments and lifestyle enhancing edible products for better health.
Claims:1. A composition comprising:
a. Andrographis paniculata extract; and
b. Vitis vinifera L. extract,
wherein Andrographis paniculata extract to Vitis vinifera L. extract w/w ratio is in the range of 1:0.16-1:1.
2. The composition as claimed in claim 1, wherein Andrographis paniculata extract to Vitis vinifera L. extract w/w ratio is 1:0.37.
3. The composition as claimed in claim 1, wherein Andrographis paniculata extract weight concentration in said composition is in the range of 0.00025-0.00075%, and Vitis vinifera L. extract weight concentration in said composition is in the range of 0.000125-0.00025%.
4. The composition as claimed in claim 2, wherein Andrographis paniculata extract weight concentration in said composition is 0.0005%, and Vitis vinifera L. extract weight concentration in said composition is 0.000187%.
5. The composition as claimed in claim 1, wherein said Andrographis paniculata extract is obtained from stems and leaves; said Vitis vinifera L. extract is obtained from seeds.
6. The composition as claimed in any of the claims 1-5, further comprising suitable carriers, diluents, and excipients.
7. A method of preparing a composition as claimed in any of the claims 1-6.
8. A method of inhibiting intracellular cholesterol levels, said method comprising:
a. obtaining a composition as claimed in any of the claims 1-6; and
b. contacting said composition with cells comprising cholesterol,
wherein said method inhibits intracellular cholesterol levels.
9. A composition as claimed in any of the claims 1-6 for use in preparing oral formulations for inhibition of intracellular cholesterol.
, Description:As Attached
| Section | Controller | Decision Date |
|---|---|---|
| # | Name | Date |
|---|---|---|
| 1 | Form 5 [11-02-2016(online)].pdf | 2016-02-11 |
| 2 | Form 3 [11-02-2016(online)].pdf | 2016-02-11 |
| 3 | Drawing [11-02-2016(online)].pdf | 2016-02-11 |
| 4 | Description(Complete) [11-02-2016(online)].pdf | 2016-02-11 |
| 5 | 201641004921-Power of Attorney-110416.pdf | 2016-06-30 |
| 6 | 201641004921-Form 1-110416.pdf | 2016-06-30 |
| 7 | 201641004921-Correspondence-Form 1-PA-110416.pdf | 2016-06-30 |
| 8 | 201641004921-FORM 18 [07-01-2020(online)].pdf | 2020-01-07 |
| 9 | 201641004921-FER.pdf | 2022-04-25 |
| 10 | 201641004921-FER_SER_REPLY [21-10-2022(online)].pdf | 2022-10-21 |
| 11 | 201641004921-CLAIMS [21-10-2022(online)].pdf | 2022-10-21 |
| 12 | 201641004921-US(14)-HearingNotice-(HearingDate-30-01-2024).pdf | 2023-12-26 |
| 13 | 201641004921-Correspondence to notify the Controller [25-01-2024(online)].pdf | 2024-01-25 |
| 14 | 201641004921-FORM-26 [30-01-2024(online)].pdf | 2024-01-30 |
| 15 | 201641004921-Written submissions and relevant documents [13-02-2024(online)].pdf | 2024-02-13 |
| 16 | 201641004921-Response to office action [23-07-2024(online)].pdf | 2024-07-23 |
| 1 | tkdl2AE_22-12-2023.pdf |
| 2 | tkdl1AE_22-12-2023.pdf |
| 3 | tkdl-d4AE_22-12-2023.pdf |
| 4 | tkdl-3AE_22-12-2023.pdf |
| 5 | 4921searchE_19-04-2022.pdf |