Abstract: The present disclosure discloses a composition comprising vanillic acid and 3-furancarboxaldehyde in a specific weight percentage in a range of 0.001-0.01% with respect to the composition. More particularly, the present disclosure discloses a composition exhibiting synergistic effect against the biofilm and hyphae formation in the species of Candida genus such as C. albicans and C. tropicalis. Also, provided is a method of preparing the composition.
I/We Claim:
1. A composition comprising:
a) vanillic acid; and
b) 3-furancarboxaldehyde,
wherein vanillic acid has a weight percentage in a range of 0.001% -0.01% with respect to the composition, and 3-furancarboxaldehyde has a weight percentage in a range of 0.001% - 0.01% with respect to the composition, and wherein vanillic acid, and 3-furancarboxaldehyde w/w ratio is in a range of 3:1 to 1:3.
2. The composition as claimed in claim 1, wherein vanillic acid to 3-furancarboxaldehyde w/w ratio is in a range of 2:1 to 1:2.
3. The composition as claimed as claimed in claim 1, wherein the composition further comprises at least one component selected from a group consisting of water phase component, oil phase component, and combinations thereof.
4. The composition as claimed as claimed in claim 3, wherein the water phase component comprises at least one water phase excipient selected from a group consisting of hydrosol, humectant, and combinations thereof, and the oil phase component comprises at least one oil phase excipient selected from a group consisting of preservative, emollient, structurant, thickener, emulsifier, and combinations thereof.
5. The composition as claimed in claim 3, wherein the composition comprises a combination of the water phase component and the oil phase component.
6. A process for preparing the composition as claimed in claim 1, said process comprising:
a) obtaining vanillic acid;
b) obtaining 3-furancarboxaldehyde; and
c) contacting vanillic acid with 3-furancarboxaldehyde at 600-1000 rpm for 2 - 10 minutes at a temperature range of 40-45 °C to obtain the composition.
7. A process for preparing the composition as claimed in any one of the
claims 3-5 said process comprising:
a) obtaining vanillic acid;
b) obtaining 3-furancarboxaldehyde;
c) obtaining at least one water phase component;
d) obtaining at least one oil phase component;
e) mixing the at least one water phase component having a weight percentage in a range of 51% - 80% with respect to the composition, with the at least one oil phase component having a weight percentage in a range of 1.1% - 42% with respect to the composition at 600 -1000 rpm for 2 - 10 minutes at a temperature range of 40-45 °C to obtain a first mixture; and
f) contacting vanillic acid having a weight percentage in a range of 0.001-0.01%) with respect to the composition, 3-furancarboxaldehyde having a weight percentage in a range of 0.001-0.01%) with respect to the composition with the first mixture at 600 -1000 rpm for 2-10 minutes at a temperature range of 40-45 °C to obtain, to obtain the composition.
8. The composition as claimed in any one of the claims 1 to 5, wherein said composition exhibits inhibitory activity against hyphal formation in species of Candida genus.
9. The composition as claimed in any one of the claims 1 to 5, wherein said composition exhibits inhibitory activity against biofilm formation in species of Candida genus.
| # | Name | Date |
|---|---|---|
| 1 | 201941007130-CLAIMS [14-03-2025(online)].pdf | 2025-03-14 |
| 1 | 201941007130-FER.pdf | 2024-10-01 |
| 1 | 201941007130-STATEMENT OF UNDERTAKING (FORM 3) [22-02-2019(online)].pdf | 2019-02-22 |
| 2 | 201941007130-CORRESPONDENCE [14-03-2025(online)].pdf | 2025-03-14 |
| 2 | 201941007130-FORM 1 [22-02-2019(online)].pdf | 2019-02-22 |
| 2 | 201941007130-FORM 18 [11-02-2022(online)].pdf | 2022-02-11 |
| 3 | 201941007130-DRAWINGS [22-02-2019(online)].pdf | 2019-02-22 |
| 3 | 201941007130-FER_SER_REPLY [14-03-2025(online)].pdf | 2025-03-14 |
| 3 | 201941007130-FORM-8 [11-02-2022(online)].pdf | 2022-02-11 |
| 4 | 201941007130-FORM-26 [14-03-2025(online)].pdf | 2025-03-14 |
| 4 | 201941007130-EDUCATIONAL INSTITUTION(S) [08-11-2021(online)].pdf | 2021-11-08 |
| 4 | 201941007130-DECLARATION OF INVENTORSHIP (FORM 5) [22-02-2019(online)].pdf | 2019-02-22 |
| 5 | Correspondence by Agent_Form26_06-05-2019.pdf | 2019-05-06 |
| 5 | 201941007130-OTHERS [14-03-2025(online)].pdf | 2025-03-14 |
| 5 | 201941007130-COMPLETE SPECIFICATION [22-02-2019(online)].pdf | 2019-02-22 |
| 6 | Correspondence by Agent_Proof of Right_06-05-2019.pdf | 2019-05-06 |
| 6 | 201941007130-Proof of Right (MANDATORY) [02-05-2019(online)].pdf | 2019-05-02 |
| 6 | 201941007130-FER.pdf | 2024-10-01 |
| 7 | 201941007130-FORM-26 [02-05-2019(online)].pdf | 2019-05-02 |
| 7 | 201941007130-FORM 18 [11-02-2022(online)].pdf | 2022-02-11 |
| 8 | 201941007130-FORM-8 [11-02-2022(online)].pdf | 2022-02-11 |
| 8 | 201941007130-Proof of Right (MANDATORY) [02-05-2019(online)].pdf | 2019-05-02 |
| 8 | Correspondence by Agent_Proof of Right_06-05-2019.pdf | 2019-05-06 |
| 9 | 201941007130-COMPLETE SPECIFICATION [22-02-2019(online)].pdf | 2019-02-22 |
| 9 | 201941007130-EDUCATIONAL INSTITUTION(S) [08-11-2021(online)].pdf | 2021-11-08 |
| 9 | Correspondence by Agent_Form26_06-05-2019.pdf | 2019-05-06 |
| 10 | 201941007130-DECLARATION OF INVENTORSHIP (FORM 5) [22-02-2019(online)].pdf | 2019-02-22 |
| 10 | 201941007130-EDUCATIONAL INSTITUTION(S) [08-11-2021(online)].pdf | 2021-11-08 |
| 10 | Correspondence by Agent_Form26_06-05-2019.pdf | 2019-05-06 |
| 11 | 201941007130-DRAWINGS [22-02-2019(online)].pdf | 2019-02-22 |
| 11 | 201941007130-FORM-8 [11-02-2022(online)].pdf | 2022-02-11 |
| 11 | Correspondence by Agent_Proof of Right_06-05-2019.pdf | 2019-05-06 |
| 12 | 201941007130-FORM 1 [22-02-2019(online)].pdf | 2019-02-22 |
| 12 | 201941007130-FORM 18 [11-02-2022(online)].pdf | 2022-02-11 |
| 12 | 201941007130-FORM-26 [02-05-2019(online)].pdf | 2019-05-02 |
| 13 | 201941007130-FER.pdf | 2024-10-01 |
| 13 | 201941007130-Proof of Right (MANDATORY) [02-05-2019(online)].pdf | 2019-05-02 |
| 13 | 201941007130-STATEMENT OF UNDERTAKING (FORM 3) [22-02-2019(online)].pdf | 2019-02-22 |
| 14 | 201941007130-COMPLETE SPECIFICATION [22-02-2019(online)].pdf | 2019-02-22 |
| 14 | 201941007130-OTHERS [14-03-2025(online)].pdf | 2025-03-14 |
| 15 | 201941007130-DECLARATION OF INVENTORSHIP (FORM 5) [22-02-2019(online)].pdf | 2019-02-22 |
| 15 | 201941007130-FORM-26 [14-03-2025(online)].pdf | 2025-03-14 |
| 16 | 201941007130-DRAWINGS [22-02-2019(online)].pdf | 2019-02-22 |
| 16 | 201941007130-FER_SER_REPLY [14-03-2025(online)].pdf | 2025-03-14 |
| 17 | 201941007130-CORRESPONDENCE [14-03-2025(online)].pdf | 2025-03-14 |
| 17 | 201941007130-FORM 1 [22-02-2019(online)].pdf | 2019-02-22 |
| 18 | 201941007130-CLAIMS [14-03-2025(online)].pdf | 2025-03-14 |
| 18 | 201941007130-STATEMENT OF UNDERTAKING (FORM 3) [22-02-2019(online)].pdf | 2019-02-22 |
| 1 | s7E_26-09-2024.pdf |