DESC:Composition for Improving Cognition

Field of the Invention
The present invention provides a nutraceutical composition comprising of amino acids, herbal extracts and B group of vitamins responsible for the sustenance of optimal cognitive functions such as memory, focus and attention in the healthy individuals.

Background of the Invention
Cognition is the process of acquiring knowledge and understanding through experience, thought and senses. Human cognition can be unconscious and conscious, concrete or abstract, as well as intuitive and conceptual. It encompasses many aspects of intellectual functions and processes like attention, formation of knowledge and working memory, judgment and evaluation, reasoning and computation, problem solving and decision making, comprehension and production of language.
In our extensive market research we found that there is no such product which combines specific ingredients from the various categories currently available in the Indian market for improving the gaming performance. Gamers have a very particular need when it comes to supplementation. These are very different from the needs of sports athletes and bodybuilders. In fact they are more complicated and specific to the cognitive performance such as faster reaction time, increased focus and enhanced working memory, brain clarity and decision making.
U. S. Patent no 20130156872 describes a synergistic combination of vitamins, alkaloids, herbs, minerals, fatty acids, lipids, and phospholipids and amino acids that provide specific support factors for improving cognitive function and mood by increasing cholinergic and monoaminergic neurotransmission, promoting synapse formation, and maintenance and providing neuroprotective effects.
U.S Patent Application No. 20160354422 describes a focus enhancing composition comprising L-theanine, Acetyl L-Carnitine, and a choline derivative present in an amount effective to raise memory and cognition levels.
U.S Patent Application No. 20180085310 describes a composition comprising Inositol, N-Acetyl L-Tyrosine, pyrrolloquinoline quinone, Choline bitartrate, L-theanine and Acetyl L-carnitine that can be used to improve brain health.
The benefits of the current compositions includes improved gaming performance by providing Phospholipid support, thus improving memory, recall and mental speed; increasing glucose and ketone conversion providing cognitive fuel, energy and endurance; improving blood flow leading to improved alertness; providing neurotransmission support leading to improved focus, alertness and concentration.
Based on the above pathways, the inventors have formulated a composition that can be used for improving the performance of gamers by increasing the processing speed, better mental recovery, improved focus and attention and better eye health.
Summary of the Invention
In one general aspect, the present invention provides a nutraceutical composition comprising:
i) Vitamins from vitamin B group;
ii) Amino acids;
iii) Plant extracts; and optionally
iv) One or more other active ingredients selected from the group consisting of L-Alpha glycerylphosphorylcholine, Glucuronolactone and caffeine.
In an embodiment of the above aspect, the vitamins are selected from the group consisting of Vitamin B1, B2, B3, B5, B6, B9 and B12 and combinations thereof. Vitamins comprise from 10 microgram to 15 mg, preferably, from 50 microgram to 13 mg by weight of the nutraceutical composition.
In an embodiment of the above aspect, the amino acids are selected from the group consisting of L-theanine, arginine, L-tyrosine, L-tryptophan, phenylalanine and taurine and combinations thereof. Amino acids comprise from 3 mg to 7 grams, preferably, from 4 mg to 5 grams by weight of the nutraceutical composition.
In another embodiment of the above aspect, the plant extracts are selected from the group consisting of Bacopa monnieri, Shankhpushpi extract, Centella asiatica, black pepper extract (bioperine), Turmeric extract, Mentha spicata extract, Ginkgo Biloba extract, Panax Ginseng extract, Alpinia galangal extract and combinations thereof. The plant extract comprise from 1 mg to 500 mg, preferably, from 50 mg to 400 mg.
In an embodiment of the above aspect, the other active ingredient comprises from 1 mg to 5 g, preferably, from 2 mg to 4.5 g.
Detailed description of the invention
The present invention is targeted for individuals involved in the electronic sports (e-sports) activities who experience mental fatigue, debilitating ability to focus and slow processing speeds. The nutraceutical composition will be useful for reducing oxidative stress and increasing neurotransmission activity to help e-gamers to improve their concentration, memory and mental agility.
Nootropics are cognition enhancers that reportedly improve mental functions such as cognition, memory, intelligence, attention and concentration. Various mechanisms by which nootropics act include increasing blood circulation to the brain, improving neuron function, providing precursors to neurotransmitters and providing usable form of energy to the brain.
The human brain contains an estimated 86 billion neurons. Those billions of brain cells communicate by passing chemical messages at the synapse, the small gap between cells, in a process called neurotransmission. Those chemical messengers are unique molecules called neurotransmitters. Neurotransmitters are endogenously produced inside the neuron itself. When a cell is activated, these neurochemicals are released into the synapse from the specialized pouches clustered near the cell membrane called synaptic vesicles. Specific receptors on the neighboring cells can then take up these neurotransmitters, which can increase or decrease the signal being passed along a particular circuit. Classification of neurotransmitters is complicated because there are over 100 different ones. Fortunately, the seven “small molecule” neurotransmitters dopamine, norepinephrine, serotonin acetylcholine, glutamate, gamma-aminobutyric acid (GABA), and are mostly involved in neurotransmission.
Dopamine is a neurotransmitter that is produced in the dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain, the substantia nigra pars compacta, and the arcuate nucleus of the hypothalamus. It helps in the transmission of signals in the brain and other vital areas. D1 receptors and D4 receptors are responsible for the cognitive-enhancing effects of dopamine. The amino acid tyrosine is taken up by dopaminergic neurons and converted by tyrosine hydroxylase to 3,4-dihydroxyphenylalanine (dopa), which is decarboxylated by aromatic-l-amino-acid decarboxylase to dopamine.
Norepinephrine is the neurotransmitter of most postganglionic sympathetic fibers and many central neurons (e.g., in the locus caeruleus and hypothalamus). The precursor tyrosine is converted to dopamine, which is hydroxylated by dopamine beta-hydroxylase to norepinephrine. It has been linked to mood, arousal, vigilance, memory, and stress.
Serotonin (5-hydroxytryptamine, or 5-HT) sometimes also called the “calming chemical,” is best known for its mood modulating effects. It is generated by the raphe nucleus and midline neurons of the pons and upper brain stem. Tryptophan is hydroxylated by tryptophan hydroxylase to 5-hydroxytryptophan, then decarboxylated to serotonin. Serotonin levels are controlled by the uptake of tryptophan. A lack of 5HT has been linked to depression and related neuropsychiatric disorders.
Acetylcholine plays a significant role in the peripheral nervous system, where it is released by motor neurons and neurons of the autonomic nervous system. It is concentrated within the nerve endings. Acetylcholine is excitatory at the neuromuscular junction in skeletal muscle, causing the muscle to contract, but inhibitory in the heart, where it slows the heart rate.
Glutamate is the major excitatory neurotransmitter in the vertebrate CNS. Glutamate also serves as a precursor for gamma-aminobutyric acid (GABA) synthesis in the brain (Pinal and Tobin, 1998).
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. It is an amino acid derived from glutamate, which is decarboxylated by glutamate decarboxylase. After interaction with its receptors, GABA is actively pumped back into nerve terminals and metabolized.
The various amino acids responsible for release of the above mentioned neurotransmitters are mentioned in Table 1 below:
Table 1: Amino Acids and Their Neurotransmitter/Neuromodulator Products
Amino Acid Neurotransmitter Functions
Tryptophan Serotonin Mood, pain, food intake, arousal
Melatonin
Tyrosine/phenylalanine Dopamine Motor function, mood, arousal
Norepinephrine Arousal, attention, anxiety
Epinephrine
Arginine Nitric Oxide Arousal, anxiety, memory

The disclosure relates to compositions and their use for improving various brain functions such as motor control, cognition, emotion, memory processing, and endocrine modulation. The compositions contain active ingredients like L-Alpha glycerylphosphorylcholine (Alpha-GPC); caffeine; amino acids like L-theanine, , arginine, l-tyrosine, L-tryptophan, phenylalanine and taurine and active ingredients like extract of Alpinia galangal, glucuronolactone, vitamins like vitamin B1, B2, B3, B5, B12, B6 and B9. The compositions further comprise botanical active ingredients like Brahmi (Bacopa monniera), Gotu Kola (Centella asiatica), turmeric extract and Shankhpushpi (Convolvulus pluricaulis).
Alpha-GPC administration increases the release of the neurotransmitter acetylcholine and facilitates learning and memory. Acetylcholine is a vital neurotransmitter that is important for the formation and maintenance of memories and overall healthy brain function. Not only does it involve both short and long term memory, but alpha-GPC has also been linked to increased oxygenation of the brain through increased blood flow to improve the ability to concentrate and focus. Alpha-GPC is the most bioavailable of the naturally occurring choline compounds, thus has been shown to be effective in supporting cognitive function and neurological, corporeal health in both pre-clinical and clinical studies. Alpha-GPC may comprise from 1 mg to 600 mg, preferably, from 50 mg to 400 mg by weight of the nutraceutical composition.
Amino acids comprise from 3 mg to 7 grams, preferably, from 4 mg to 5 grams by weight of the nutraceutical composition.
L-Theanine increases dopamine and serotonin production in the brain and induces relaxation through the enhancement of alpha wave activity in brain. In central nervous system, there are two main competing neurotransmitters: the inhibitory neurotransmitter, GABA, and the excitatory neurotransmitter, glutamate. The GABA and glutamate pathways are linked to many other neurotransmitters like dopamine, and serotonin. Any change in the levels of these two neurotransmitters can affect other neurotransmitters. L-Theanine stimulates GABA release. It promotes GABA release indirectly by interacting with glutaminergic neurons. Since L-theanine’s molecular structure is analogous to the molecular structure of the amino acid glutamine and glutamate, it can block transporters and receptors important for the release of glutamate. This means L-theanine regulates the balance of neurotransmitters in the brain, promoting GABA (inhibitory) over glutamate (excitatory), consequently, increasing other neurotransmitters like dopamine and serotonin. To put it in simple terms, L-theanine can activate the brain’s calming pathways, also influences other neurotransmitters important for mood, motivation, attention, and memory. The effects of L-theanine are often in combination with caffeine because of its synergistic effects. Together, they increase attention, alertness and accuracy in healthy adults during cognitive testing. L-theanine may comprise from 1 mg to 100 mg, preferably, from 25 mg to 100 mg by weight of the nutraceutical composition.
Caffeine is a well-known stimulant that affects numerous neurotransmitter and endocrine signaling pathways. By inhibiting phosphodiesterase, caffeine enhances signaling through adrenergic pathways resulting in increased heart rate. Caffeine antagonizes signaling through adenosine receptors, and increases release of catecholamines. Caffeine may comprise from 1 mg to 200 mg, preferably, from 25 mg to 150 mg by weight of the nutraceutical composition.
L-Arginine metabolism in the brain is very important for normal brain function. In addition to brain protein synthesis, arginine is a substrate for the production of urea, creatine, nitric oxide, agmatine, glutamic acid, ornithine, proline and polyamines. All these compounds are vital for brain function. L-arginine may comprise from 10 mg to 2 g, preferably, from 100 mg to 1.5 g by weight of the nutraceutical composition. Bonded inositol arginine silicate may be added in dosage form 0.5g to 1.5 g per day.
L- Tyrosine is an essential amino acid which supports brain function. It helps to produce the neurotransmitters (Dopamine, Norepinephrine and Epinephrine), hormones which are depleted by stress, excessive work and certain drugs. Norepinephrine is believed to play a critical role in the response of the brain to acute stress. Exposure to heat, cold, cardiovascular stressors, and electric shock produce significant increase in brain catecholaminergic activity. Central noradrenergic neurons seem to be critical for regulating key behavioral parameters such as attention, arousal level, and mood state. Although norepinephrine appears to be particularly critical for the brain's response to stress, another brain catecholamine, dopamine, also appears to be involved in certain aspects of the acute response to various stressors. By replenishing catecholamines, mental energy levels are enhanced and a sense of contentment often occurs. L tyrosine boosts neurotransmitter production within the brain thereby helping to create alertness. It is converted in the body into other key biological compounds, including L-Dopa, CoQ10, thyroid hormones and melanin. L-tyrosine may comprise from 100 mg to 2000 mg, preferably, from 500 mg to 1500 mg by weight of the nutraceutical composition.
L-Tryptophan helps to improve decision making, stabilizes mood and influences the cognitive process, specifically learning and memory. It is a precursor of two important neurotransmitters (Acetylcholine and Serotonin). Acetylcholine is essential in memory formation and maintenance while Serotonin helps with sleep regulation and reduction of anxiety. L-tryptophan may comprise from 1 mg to 500 mg, preferably, from 50 mg to 500 mg by weight of the nutraceutical composition.
Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one among the DNA-encoded amino acids. L-tyrosine is successively converted into L-DOPA, which is further converted into dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). Phenylalanine may comprise from 1mg to 700 g, preferably, from 100 mg to 500 mg by weight of the nutraceutical composition.
Taurine is a sulfur-containing amino acid with antioxidant properties that is found in high levels in the developing brain, as well as in the adult hippocampus, cerebellum, and hypothalamus. Taurine supports proliferation of neural progenitor cells and synapse formation in brain regions required for long-term memory. Taurine stimulates action potentials in GABAnergic neurons and specifically targets the GABA receptor. Taurine may comprise from 100 mg to 1500 mg, preferably, from 250 mg to 1200 mg by weight of the nutraceutical composition.
EnXtra is the first and only botanical ingredient proven to provide same day effect and improve alertness and focus up to 5 hours with and without caffeine. Made from a proprietary extract of Alpinia galanga, it targets a cognitive process known as “Attention Network Function” (ANF), which is the ability of the brain to allocate processing resources to a specific task. The ANF system plays a critical role in mental alertness and the ability to focus on a task. EnXtra may comprise from 10 mg to 300 mg, preferably, from 50 mg to 300 mg by weight of the nutraceutical composition.
Glucuronolactone is a physiologically inactive substance that is converted into an active substance (taurine) through a chemical process. Glucuronolactone is a naturally occurring metabolite in the body that is produced by the metabolism of glucose in the liver. Glucuronolactone may comprise from 10 mg to 600 mg, preferably, from 10 mg to 500 mg by weight of the nutraceutical composition.
The B group of vitamins play a key role in ensuring that the brain achieves its full potential. They keep humans energized, positive and focused on a day-to-day basis, while helping promote long-term brain health as we move through life. Vitamins B12, B6 and B9 help metabolize homocysteine, reducing its concentration in the bloodstream, and possibly helping to prevent long-term damage to brain tissue. Vitamin B1 helps in nerve cell function and helps in converting carbohydrates into glucose which helps in the production of Acetylcholine and GABA. Vitamin B5 acts as a cofactor in the conversion of choline to acetylcholine. Vitamins may comprise from 10 microgram to 15 mg, preferably, from 50 microgram to 13 mg by weight of the nutraceutical composition.
The plant extract comprise from 1 mg to 500 mg, preferably, from 50 mg to 400 mg by weight of the composition.
Brahmi (Bacopa monniera) is an ayurvedic herb and keeps the brain safe from free radical damage, stimulating improved learning. The medical properties have been derived from two main alkaloids - brahmine and herpestine. When taken on a regular basis, it enhances concentration, improves memory and retention capacity. Bacopa monnieri may comprise from 10 mg to 200 mg, preferably, from 50 mg to 150 mg by weight of the nutraceutical composition.
Centella asiatica contains the components triterpenes including asiaticoside, madecassoside, asiatic acid, and madecassic acid, which have antioxidant, anti-inflammatory properties. Centella asiatica may comprise from 1 mg to 300 mg, preferably, from 50 mg to 200 mg by weight of the nutraceutical composition.
Black pepper is a staple seasoning in many households around the globe. Its distinct flavor is due to the presence of piperine, a compound that has been linked to a long list of health benefits. The chemical piperine is a major bioactive component present in black pepper. BioPerine is a piperine extract that contains at least 95% piperine in a form that is well absorbed by the body. The scientific literature provides evidence that black pepper may have health benefits, particularly in enhancing digestive tract function. There is suggestive evidence that black pepper piperine may have nervous system benefits. Preliminary evidence in cell culture studies suggests that black pepper contains antioxidant constituents and possesses anti-inflammatory and antimicrobial properties. Bioperine extract may comprise from 1 mg to 50 mg, preferably, from 1 mg to 10 mg by weight of the nutraceutical composition.
Shankhpushpi (Convolvulus pluricaulis, Clitoria ternatea) is widely recognized for its anxiolytic, antidepressant and nootropic activities. It contains volatile oil; fatty alcohols; flavonoids, i.e. kaempferol; hydroxy cinnamic acid; ß-sitosterol; and carbohydrates such as glucose, rhamnose, sucrose etc., which endow this plant with nootropic capabilities. Moreover, an alkaloid, namely, convolvine present in this herb has also been found to block cholinergic muscarinic receptors: M2 and M4. Convolvine also aids in potentiating the effect of another muscarinic memory enhancer, namely, arecoline, thereby imparting nootropic abilities to shankhpushpi. Shankhpushpi extract may comprise from 1 mg to 400 mg, preferably, from 50 mg to 200 mg by weight of the nutraceutical composition.
Turmeric (Curcuma longa) cognitive benefits stem from its anti-inflammatory and/or anti-amyloid brain effects leading to improvement in memory and modulating mood. Curcumin extract may comprise from 1 mg to 400 mg, preferably, from 50 mg to 200 mg by weight of the nutraceutical composition.
Spearmint (Mentha spicata) aerial parts contain polyphenols such as rosmarinic acid and salvianolic acid, which have been shown to have anticholinesterase, antioxidant, and anti-inflammatory activities in neuronal cells. Spearmint extract may comprise from 1 mg to 500 mg, preferably, from 50 mg to 200 mg by weight of the nutraceutical composition.
Ginkgo (Ginkgo Biloba) increases cerebral blood flow thereby improving oxygen and glucose availability to neurons for neuronal health leading to improved memory, recall, and learning. It increases dopamine in the brain by acting as a monoamine oxidase inhibitor which reduces levels of monoamine oxidase in the brain. Ginkgo Biloba extract may comprise from 1 mg to 600 mg, preferably, from 50 mg to 200 mg by weight of the nutraceutical composition.
Panax Ginseng contains active compounds called Ginsenosides that increase protein synthesis and the activity of neurotransmitters in the brain. It stimulates the formation of blood vessels and improves blood circulation in the brain which thereby improves memory and quicker thinking. Ginseng may comprise from 1 mg to 500 mg, preferably, from 50 mg to 200 mg by weight of the nutraceutical composition.
The nutraceutical composition can be taken in the dosage amount of from 0.5g to 10g depending upon the requirement of the consumer. The selected dose would provide the required amounts of the active ingredients.
The nutraceutical composition can be developed in different formulations such as tablets, chewable tablets, powder, bars, capsules, RTDs, gummies etc.

Examples
The present invention will be further described having reference to the following examples, by way of illustration only.
All the components were weighed according to the compositions defined below and blended. The blend was sieved together and further blended for 20 minutes at 15 rpm. The above blend may be added to any of the ready to mix powder that may be protein, pre workout, gainer composition or any other suitable health/nutraceutical supplement. The quantity of the blend will depend upon the intended use of the supplement. Other excipients like flavour, salt, gums, sweetener, acidity regulators and other suitable fillers like dextrose, maltodextrin, fruit powders etc. may be added as per the composition requirement to make the product palatable.

Example 1:
S. No. Active Ingredients Quantity
(Milligram)
1. Vitamin B2 0.750
2. Vitamin B3 9.000
3. Vitamin B6 1.800
4. Vitamin B12 0.000750
5. Tryptophan 250
6. Taurine 1000
7. L Arginine alpha ketoglutarate 500
8. Caffeine Anhydrous 80
9. Bioperine 5
10. Theanine 50
11. Centella asiatica 50
12. Shankhpushpi Extract 50
13. Bacopa monnieri 50
14. Choline bitartarate 250
15. Phenylalaline 500
16. Glucuronolactone 100
17. Tyrosine 500
18. EnXtra 150

Example 2:
S. No. Active Ingredients Quantity
(Milligrams)
1. Vitamin B2 0.750
2. Vitamin B3 9.000
3. Vitamin B6 1.800
4. Vitamin B12 0.000750
5. Tryptophan 250
6. Taurine 500
7. L Arginine alpha ketoglutarate 500
8. Caffeine Anhydrous 100
9. Bioperine 5
10. Theanine 50
11. Centella asiatica 100
12. Shankhpushpi Extract 100
13. Bacopa monnieri 100
14. Choline bitartarate 250
15. Phenylalaline 500
16. Glucuronolactone 100
17. Tyrosine 500

Example 3:
S. No. Active Ingredients Quantity
(Milligrams)
1. Vitamin B2 0.750
2. Vitamin B3 9.000
3. Vitamin B6 1.800
4. Vitamin B12 0.000750
5. Tryptophan 250
6. Taurine 500
7. L Arginine alpha ketoglutarate 500
8. Caffeine Anhydrous 100
9. Bioperine 5
10. Theanine 100
11. Centella asiatica 100
12. Shankhpushpi Extract 100
13. Bacopa monnieri 100
14. Glucuronolactone 100
15. Phenylalaline 500
16. Tyrosine 500
17. Enxtra 200

Example 4:
S. No. Active Ingredients Quantity
(Milligrams)
1. Vitamin B2 0.750
2. Vitamin B3 9.000
3. Vitamin B6 1.800
4. Vitamin B12 (microgram) 0.750
5. Tryptophan 250
6. Taurine 500
7. L Arginine alpha ketoglutarate 500
8. Caffeine Anhydrous 120
9. Bioperine 5
10. Theanine 50
11. Centella asiatica 50
12. Shankhpushpi Extract 50
13. Bacopa monnieri 50
14. Glucuronolactone 150
15. Phenylalaline 500
16. Tyrosine 500

Example 5:
S. No. Active Ingredients Quantity
(Milligrams)
1. Vitamin B2 0.750
2. Vitamin B3 9.000
3. Vitamin B6 1.800
4. Vitamin B12 0.000750
5. Tryptophan 250
6. Taurine 500
7. L Arginine alpha ketoglutarate 500
8. Caffeine Anhydrous 120
9. Bioperine 5
10. Theanine 50
11. Centella asiatica 50
12. Shankhpushpi Extract 50
13. Bacopa monnieri 50
14. Glucuronolactone 150
15. Phenylalaline 500
16. Tyrosine 500
17. EnXtra 300
18. Curcuma Longa Extract 50

Example 6:
S. No. Active Ingredients Quantity
(Milligrams)
1. Vitamin B2 0.750
2. Vitamin B3 9.000
3. Vitamin B6 1.800
4. Vitamin B12 0.000750
5. Tryptophan 250
6. Taurine 500
7. L Arginine alpha ketoglutarate 500
8. Caffeine Anhydrous 120
9. Bioperine 5
10. Theanine 100
11. Centella asiatica 100
12. Shankhpushpi Extract 100
13. Bacopa monnieri 100
14. Glucuronolactone 100
15. Phenylalaline 500
16. Tyrosine 1000
17. Ginkgo Biloba Extract 75
18. Panax Ginseng Extract 50

Example 7:
S. No. Active Ingredients Quantity
(Milligrams)
1. Vitamin B2 0.750
2. Vitamin B3 9.000
3. Vitamin B6 1.800
4. Vitamin B12 0.000750
5. Tryptophan 250
6. Taurine 1000
7. L Arginine alpha ketoglutarate 1000
8. Caffeine Anhydrous 135
9. Bioperine 5
10. Theanine 100
11. Centella asiatica 50
12. Shankhpushpi Extract 50
13. Bacopa monnieri 50
14. Phenylalaline 500
15. Alpha GPC 250
16. Glucuronolactone 100
17. Tyrosine 1000
18. Curcuma Longa Extract 50
19. Spearmint Extract 100
20. Ginkgo Biloba Extract 50
21. Panax Ginseng Extract 50

A group of panelists was chosen and comparative efficacy studies were done. On comparing the prototype with Benchmark (Gfuel market sample), the prototype was found to be better as shown in Table 2.

Table 2: Comparison of the activity of composition of the invention with a marketed composition
S. No. Sensory Attributes Prototype A
(Example 7) Benchmark
(Gfuel)
1 Mental Focus 3.5 3
2 Reaction Time 3.5 2
3 Energy 4 3 ,CLAIMS:1. A nutraceutical composition comprising:
i. Vitamins from vitamin B group;
ii. Amino acids;
iii. Plant extracts; and optionally
iv. Other one or more active ingredients selected from the group consisting of L-Alpha glycerylphosphorylcholine, Glucuronolactone and caffeine.
2. The nutraceutical composition as claimed in claim 1, wherein the vitamins are selected from the group consisting of Vitamin B1, B5, B6, B9 and B12 and combinations thereof.
3. The nutraceutical composition as claimed in claim 1, wherein the amino acids are selected from the group consisting of L-theanine, arginine, L-tyrosine, L-tryptophan, phenylalanine and taurine and combinations thereof.
4. The nutraceutical composition as claimed in claim 1, wherein the plant extracts are selected from the group consisting of Bacopa monnieri, Shankhpushpi extract, Centella asiatica and black pepper extract (bioperine), Turmeric extract, Mentha spicata extract, Ginkgo Biloba extract, Panax Ginseng extract, Alpinia galangal extract and combinations thereof.
5. The nutraceutical composition as claimed in claim 1, wherein vitamins comprise from 10 microgram to 15 mg by weight of the nutraceutical composition.
6. The nutraceutical composition as claimed in claim 1, wherein the amino acids comprise from 3 mg to 7 grams by weight of the nutraceutical composition.
7. The nutraceutical composition as claimed in claim 1, wherein the plant extract comprise from 1 mg to 500 mg by weight of the nutraceutical composition.
8. The nutraceutical composition as claimed in claim 1, wherein the other active ingredients comprise from 1 mg to 5g by weight of the nutraceutical composition.
9. The nutraceutical composition as claimed in claim 1, wherein the nutraceutical composition is formulated in the form of tablets, chewable tablets, powder, bars, capsules, RTDs and gummies.
10. The nutraceutical composition as claimed in claim 1, wherein the dosage amount of from 0.5g to 10g depending upon the requirement of the consumer.