DESC:FIELD OF THE INVENTION
[0001] The present disclosure pertains to a composition for syndet bar. Particularly the present disclosure relates to a composition comprising parabiotic for syndet based bar. In particular the present disclosure relates to a composition comprising parabiotic and syndet base for bathing bar, especially for sensitive skin, and humans having a compromised skin barrier.

BACKGROUND OF THE INVENTION
[0002] The background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.
[0003] The word syndet is derived from synthetic combined with detergent. Syndet bars comprise different detergents, also called surfactants or tension-active agents. Technically these detergents, having an affinity for oils, bind to them repelling water, surround dirt with small structures that are then removed by water.
[0004] Syndet bars referred as cleansing bars or dermatological bars occupy a vast majority of market as against the traditional vegetable oil soaps. Traditional vegetable oil based commercial soaps often contain free alkali which increases the pH and makes them harsh and drying to the skin. The long term use of traditional soaps is considered to causes irreversible damage to the acid mantle.
[0005] Syndet bars are generally recommended for cleansing sensitive skin and even baby skin, as they are far more gentle and skin-friendly than traditional soaps.
[0006] From a technical standpoint, syndet bars are considered to have advantages over traditional soap, that syndet allows including additives preferred by large population of consumers like colourants and fragrances that are not suitable to be included in traditional soaps due to the high pH environment.
[0007] However, conventional syndet soap compositions comprise sulphates, parabens, phthalates which are harmful for sensitive skin population with compromised skin barrier function. Often for this reason syndets are now not preferred for babies and those suffering from dermatological conditions.
[0008] Therefore, there is an unmet need in the art to provide a composition for syndet bar which is devoid of harmful constituents like sulphates, parabens, phthalates and still provide effective cleaning properties and without drying out the skin of those having sensitive skin.

OBJECTS OF THE INVENTION
[0009] It is an object of the present disclosure to provide a composition for syndet bar with effective cleaning properties without drying out the skin.
[00010] It is an object of the present disclosure to provide a composition for syndet bar which is sulphate free.
[00011] It is an object of the present disclosure to provide a composition for syndet bar which is devoid of parabens, phthalates which are harmful for skin.
[00012] It is an object of the present disclosure to provide a composition for syndet bar comprising additional moisturizing ingredient(s) to further repair the skin barrier.
[00013] It is an object of the present disclosure to provide a composition for syndet bar comprising parabiotic.

SUMMARY OF THE INVENTION
[00014] The present disclosure discloses a composition for syndet bar comprising 97-99 % wt. of syndet base; 0.15-0.75 % wt. of parabiotic; 0.025-0.5 % wt. of additional moisturizing ingredient; and 0.025-0.5 % wt. of cosmetic acceptable excipient.
[00015] The present disclosure pertains to a composition for syndet bar with effective cleaning properties without drying out the skin.
[00016] In an aspect the present disclosure provides a composition for syndet bar which is sulphate free.
[00017] In an aspect the present disclosure provides a composition for syndet bar which is devoid of parabens, phthalates which are harmful for skin.
[00018] Various objects, features, aspects and advantages of the inventive subject matter will become more apparent from the following detailed description of preferred embodiments.

DETAILED DESCRIPTION OF THE INVENTION
[00019] The following is a detailed description of embodiments of the present disclosure. The embodiments are in such detail as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims.
[00020] Unless the context requires otherwise, throughout the specification which follow, the word “comprise” and variations thereof, such as, “comprises” and “comprising” are to be construed in an open, inclusive sense that is as “including, but not limited to.”
[00021] Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
[00022] As used in the description herein and throughout the claims that follow, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise.
[00023] In some embodiments, the numbers expressing quantities of ingredients, properties such as concentration, and so forth, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term “about.” Accordingly, in some embodiments, the numerical parameters set forth in the written description are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.
[00024] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein.
[00025] All methods described herein can be performed in suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g. “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
[00026] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments.
[00027] Various terms are used herein. To the extent a term used is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.
[00028] The present disclosure discloses a composition for syndet bar comprising: 97-99 % wt. of syndet base; 0.15-0.75 % wt. of parabiotic; 0.025-0.5 % wt. of additional moisturizing ingredient; and 0.025-0.5 % wt. of cosmetic acceptable excipient.
[00029] The syndet base is selected from the group consisting of sodium cocoyl lsethionate, glyceryl mono stearate, stearic acid, cocamidopropyl betaine, glycerin, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, disodium EDTA, potassium chloride, starch, aqua and phosphoric acid or combination thereof.
[00030] The parabiotic is Lactobacillus ferment. Lactobacillus ferment is a Lactobacillus sp. ferment adsorbed on a substrate like maltodextrin. Lactobacillus sp. ferment is in the range of 30% to 50% and maltodextrin is in the range of 50% to 70% by weight of the final Lactobacillus sp. ferment adsorbed on the substrate.
[00031] The additional moisturizing ingredient is selected from the group consisting of avocado oil, shea butter, olive oil or ester of olive oil, coco glucoside, glyceryl oleate, sodium L-pyrrolidone carboxylate, aqua, or the like or combinations thereof.
[00032] The cosmetically acceptable excipient is selected from a group of consisting of fragrance, fillers or carriers or combination thereof. The fragrance is present in the range of 0.5% to 1% by weight.
[00033] The composition comprises other component. The other component is selected from a group consisting of surfactants, colorants, emollients, emulsifiers, UV light protection filters, antioxidants, solids and fillers, pearlescing additives, deodorant and antiperspirant active ingredients, insect repellents, care additives and superfatting agents or combination thereof.
[00034] The present disclosure pertains to a composition for syndet bar with effective cleaning properties without drying out the skin.
[00035] In one embodiment the present disclosure provides a composition for syndet bar which is sulphate free.
[00036] In one embodiment the present disclosure provides a composition for syndet bar which is devoid of parabens, phthalates which are harmful for skin.
[00037] In one embodiment the present disclosure provides a composition for syndet bar comprising additional moisturizing ingredient(s) suitable for sensitive skin and capable of repairing the skin barrier.
[00038] In one embodiment the present disclosure provides a composition for syndet bar comprising parabiotic.
[00039] In one embodiment the present disclosure provides a composition for syndet bar comprising syndet base and parabiotic for example Lactobacillus ferment.
[00040] In one embodiment the present disclosure provides a composition for syndet bar comprising syndet base, parabiotic for example Lactobacillus ferment, additional moisturizing ingredient(s), and cosmetically acceptable excipients.
[00041] The syndet base to be included in the composition for the syndet bar in accordance with the present disclosure comprises one or more of sodium cocoyl lsethionate, glyceryl mono stearate, stearic acid, cocamidopropyl betaine, glycerin, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, disodium EDTA, potassium chloride, starch, aqua, phosphoric acid or the like.
[00042] Lactobacillus ferment is a parabiotic which is lysed parabiotic with intact cell walls. It is mildly heat treated to exert the metabolites like antimicrobial peptides (AMPs).
[00043] In one embodiment the Lactobacillus ferment is a Lactobacillus sp. ferment adsorbed on a substrate like maltodextrin.
[00044] In one embodiment the Lactobacillus sp. ferment adsorbed on a substrate like maltodextrin comprises Lactobacillus sp. ferment in about 30% to about 50% and maltodextrin is about 50% to about 70% by weight of the final Lactobacillus sp. ferment adsorbed on the substrate.
[00045] Without bound by any theory it is believed that Lactobacillus ferment comprising metabolites like antimicrobial peptides (AMPs) induce anti-inflammatory response on the skin.
[00046] The composition for syndet bar in accordance with the present disclosure comprises additional moisturizing ingredient selected from avocado oil, shea butter, olive oil or ester of olive oil for example sodium PEG-7 olive oil carboxylate, coco glucoside, glyceryl oleate, sodium L-pyrrolidone carboxylate (Sodium PCA), aqua, or the like or combinations thereof.
[00047] The composition for syndet bar in accordance with the present disclosure comprises cosmetically acceptable excipient selected from fragrance(s), fillers or carriers like starch, maltodextrin, or the like or combination thereof.
[00048] The fragrance to be included in the composition for syndet bar in accordance with the present disclosure are selected from hypoallergenic, phthalate free fragrance.
[00049] The composition for syndet bar may further comprise additional moisturizing ingredients, or some of the additional moisturizing ingredients listed hereinabove may be altered with additional moisturizing ingredients with similar properties.
[00050] The composition for syndet bar according to the present disclosure may comprise as further components in particular, for example those which are selected, for example, from the group of surfactants, colorants, emollients, emulsifiers, UV light protection filters, antioxidants, solids and fillers, pearlescing additives, deodorant and antiperspirant active ingredients, insect repellents, care additives, superfatting agents, or any other constituent required to achieve a desired property or function.
[00051] In one embodiment, the present disclosure provides a composition for syndet bar comprising sulphate free syndet base, Lactobacillus ferment, shea butter, olive oil ester, sodium PCA, and cosmetically acceptable excipient(s).
[00052] In one embodiment, the present disclosure provides a composition for syndet bar comprising sulphate free syndet base, Lactobacillus ferment, shea butter, avocado oil, olive oil ester, sodium PCA, and cosmetically acceptable excipient(s).
[00053] In one embodiment the syndet base is present in the range of about 90% to about 99% by weight of the composition.
[00054] In one embodiment the syndet base is present in the range of about 95% to about 99% by weight of the composition.
[00055] In one embodiment the syndet base is present in the range of about 97% to about 99% by weight of the composition.
[00056] In one embodiment L. ferment adsorbed on maltodextrin is present in the range of about 0.15% to about 0.75% by weight of the composition.
[00057] In one embodiment L. ferment adsorbed on maltodextrin is present in the range of about 0.2% to about 0.7% by weight of the composition.
[00058] In one embodiment L. ferment adsorbed on maltodextrin is present in the range of about 0.25% to about 0.5% by weight of the composition.
[00059] In one embodiment avocado oil is present in the range of about 0.025% to about 0.2% by weight of the composition.
[00060] In one embodiment avocado oil is present in the range of about 0.03% to about 0.15% by weight of the composition.
[00061] In one embodiment avocado oil is present in the range of about 0.05% to about 0.1% by weight of the composition.
[00062] In one embodiment shea butter is present in the range of about 0.025% to about 0.2% by weight of the composition.
[00063] In one embodiment shea butter is present in the range of about 0.03% to about 0.15% by weight of the composition.
[00064] In one embodiment shea butter is present in the range of about 0.05% to about 0.1% by weight of the composition.
[00065] In one embodiment sodium PEG-7 olive oil carboxylate is present in the range of about 0.025 % to about 0.5 % by weight of the composition.
[00066] In one embodiment sodium PEG-7 olive oil carboxylate is present in the range of about 0.05% to about 0.4% by weight of the composition.
[00067] In one embodiment sodium PEG-7 olive oil carboxylate is present in the range of about 0.1% to about 0.3% by weight of the composition.
[00068] In one embodiment coco glucoside and glyceryl oleate is present in the range of about 0.025% to about 0.5 % by weight of the composition.
[00069] In one embodiment coco glucoside and glyceryl oleate is present in the range of about 0.05% to about 0.4% by weight of the composition.
[00070] In one embodiment coco glucoside and glyceryl oleate is present in the range of about 0.1% to about 0.3% by weight of the composition.
[00071] In one embodiment sodium L-pyrrolidone carboxylate in aqua is present in the range of about 0.025% to about 0.5% by weight of the composition.
[00072] In one embodiment sodium L-pyrrolidone carboxylate in aqua is present in the range of about 0.03% to about 0.3% by weight of the composition.
[00073] In one embodiment sodium L-pyrrolidone carboxylate in aqua is present in the range of about 0.05% to about 0.1% by weight of the composition.
[00074] In one embodiment fragrance is present in the range of about 0.025% to about 0.5% by weight of the composition.
[00075] In one embodiment fragrance is present in the range of about 0.03% to about 0.3% by weight of the composition.
[00076] In one embodiment fragrance is present in the range of about 0.05% to about 0.1% by weight of the composition.
[00077] In one embodiment the composition for syndet bar comprises syndet base comprising sodium cocoyl lsethionate, glyceryl mono stearate, stearic acid, cocamidopropyl betaine, glycerin, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, disodium EDTA, potassium chloride, starch, aqua, and phosphoric acid; L. ferment adsorbed on maltodextrin; avocado oil; shea butter; sodium PEG-7 olive oil carboxylate; sodium L-pyrrolidone carboxylate in aqua; coco glucoside and glyceryl oleate; and fragrance in defined concentrations.
[00078] In one embodiment the composition for syndet bar comprises about 97% to about 99% by weight of syndet base comprising sodium cocoyl lsethionate, glyceryl mono stearate, stearic acid, cocamidopropyl betaine, glycerin, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, disodium EDTA, potassium chloride, starch, aqua, and phosphoric acid; about 0.25% to about 0.5% by weight of L. ferment adsorbed on maltodextrin; about 0.05% to about 0.1% by weight of avocado oil; about 0.05% to about 0.01% by weight of shea butter; about 0.05% to about 0.5 % by weight of sodium PEG-7 olive oil carboxylate; about 0.05% to about 0.1% by weight of sodium L-pyrrolidone carboxylate in aqua; about 0.5% to about 1% by weight of coco glucoside and glyceryl oleate; and about 0.5% to about 1% by weight of fragrance.
[00079] In another embodiment the present disclosure provides a formulation for a syndet bathing bar comprising a composition in accordance with the present disclosure comprising syndet base, parabiotic for example Lactobacillus ferment, additional moisturizing ingredient(s) and cosmetically acceptable excipients.
[00080] The syndet bar prepared from composition in accordance with the present disclosure is dermatologically safe and hypoallergenic.
[00081] The syndet bar comprising composition in accordance with the present disclosure is capable to balance skin microbiome and results in improved skin barrier function on regular use.
[00082] The syndet bar comprising composition in accordance with the present disclosure is suitable for use in babies, babies having sensitive skin, and babies with atopic dermatitis (AD).
EXAMPLES
[00083] The present disclosure is further explained in the form of following examples. However, it is to be understood that the foregoing examples are merely illustrative and are not to be taken as limitations upon the scope of the invention. Various changes and modifications to the disclosed embodiments will be apparent to those skilled in the art. Such changes and modifications may be made without departing from the scope of the invention.
Example 1
[00084] The present disclosure discloses a syndet bar. The composition of syndet bar is given in the below table 1:
Table 1:
Ingredient % Qty
Syndet base 98.80%
Fragrance 0.50%
Parabiotic 0.25%
Tinogard TT 0.10%
Disodium EDTA 0.10%
Avocado oil 0.05%
Shea butter 0.05%
Sodium PCA 0.05%
Olivem 0.05%
Coco glucoside, glyceryl oleate 0.05%

Example 2: Scorad Index

[00085] It is observed that 32.6 % in atopic dermatitis severity observed post 30 days of daily skidel bar application as shown in Fig. 1 and below table 2:
Table 2:
1 2
Visit 1 36.8 41.3
Visit 2 26.8 25.8

SCORAD Index assess the extent and severity of Atopic Dermatitis (AD) and evaluates improvement in AD management post treatment. In addition to objective signs such as extension, severity of signs and symptoms like erythema, Oedema, lichenification and dryness, SCORAD Index also considers subjective signs like irritability and loss of sleep. After 30 days of skidel bar application, 32.6% reduction in SCORAD Index is observed indicating management of subjective signs and reduction in objective signs.
Example 3: Eczema Area and Severity Index (EASI): Severity Score
[00086] It is observed that 8.3 % reduction in atopic dermatitis severity observed post 30 days of daily skidel bar application as shown in Fig. 2 and below table 3:
Table 3:
1 2
Visit 1 3.0 4.2
Visit 2 3.0 3.6

EASI Score measures the severity of clinical signs in atopic dermatitis and evaluates improvement in AD management post treatment. It assesses four AD characteristics such as erythema, thickness, scratching and lichenification on a scale of 0 (absent) to 3 (severe) in four different part of the body, namely Head & Neck, Upper Limbs, trunk and lower limbs. After 30 days of skidel bar application, 8.3% reduction in EASI score is observed indicating reduction in severity of clinical signs of AD.

Example 4: Staphylococcus Aureus
[00087] It is observed that 25% showed no growth in staphylococcus aureus after 30 days of daily application using skidel bar application as shown in Fig. 3 and below table 4:
Table 4:
1 2
Visit 1 No growth Mild growth
Visit 2 No growth Scanty growth

(Staphylococcus aureus is associated with the severity, pathogenesis and exacerbation of AD. Increase in colonization triggers Th2 and IgE response which exacerbates inflammation and itching which further increases risk of various invasive infections. After 30 days of skidel bar application, 25% reduction in growth of Staphylococcus aureus is observed indicating reduction in severity of clinical signs of AD.
Example 5: Visual Analogue Scale (VAS)
[00088] There is 55.5% reduction in pruritus severity observed post 30 days of daily Skidel bar application as shown in Fig. 4 and below table 5:
Table 5:
1 2
Visit 1 4 5
Visit 2 2 2
Itching Score helps to assess severity of pruritis, a disease-defining symptom of atopic dermatitis. After 30 days of skidel bar application, 55.5% reduction in pruritis is observed indicating reduction in severity of clinical signs of AD.
Example 6: Moisture Content
[00089] For affected area, skin hydration at the epidermis and the upper dermis is increased by 24.2% after 30 days of daily skidel bar application as shown in Fig. 5 and below table 6:

Table 6:
1 2
Visit 1 15% 20%
Visit 2 24% 20%

Measuring moisture content is one of the important factors in AD as it helps to assess the skin’s integrity and the degree of skin hydration of the epidermis layer. After 30 days of Skidel bar application, 24.2% increase in skin hydration at the epidermis and the upper dermis is observed which helps in management of clinical signs of AD.
Example 7: Transdermal water loss
[00090] For affected area, transepidermal water loss (TEWL) is decreased by 34% after 30 days of daily skidel foam and Tep AD with parabiotic application as shown in Fig. 6 and below table 7:
Table 7:
1 2
Visit 1 12.8 17.8
Visit 2 9.6 10.6

TEWL helps in assessing the barrier function of skin in atopic dermatitis. It assesses the quantity of condensed water that diffuses across a fixed area of stratum corneum to the skin surface per unit time. Due to dysfunction of skin barrier, patients with AD display higher TEWL. After 30 days of skidel bar application, 34% decrease in TEWL is observed which indicates lesser water loss and better management of clinical signs of AD.

ADVANTAGES OF THE INVENTION
[00091] The present disclosure provides a composition for syndet bar with effective cleaning properties without drying out the skin.
[00092] The composition for syndet bar in accordance with the present disclosure is sulphate free.
[00093] The composition for syndet bar in accordance with the present disclosure is devoid of parabens, phthalates which are harmful for skin.
[00094] The composition for syndet bar in accordance with the present disclosure is suitable for sensitive skin and capable of repairing the skin barrier.
[00095] The composition in accordance with the present disclosure; the formulation and syndet bar comprising the composition in accordance with the present disclosure are capable of exhibiting one or more action(s) like: (a) strengthen the skin barrier function, and/or; (b) reduce trans-epidermal water loss, and/or; (c) reduce pathogenic bacteria like S. aureus, and/or; (d) maintain and/or establish and/or restore a healthy state of the skin microbiome, and/or (e) improvement of severity scoring of atopic dermatitis: the SCORAD index.
[00096] This invention has been described in terms of specific embodiments set forth in detail, but it should be understood that these are by way of illustration only and that the invention is not necessarily limited thereto. Modifications and variations will be apparent from this disclosure and may be achieved without departing from the scope of this invention, as those skilled in the art will readily understand. Accordingly, such variations and modifications of the disclosed embodiments are considered to be within the purview and scope of this invention and the following claims.
,CLAIMS:1. A composition for syndet bar comprising:
97-99 % wt. of syndet base;
0.15-0.75 % wt. of parabiotic;
0.025-0.5 % wt. of additional moisturizing ingredient; and
0.025-0.5 % wt. of cosmetic acceptable excipient.
2. The composition as claimed in claim 1, wherein the syndet base is selected from the group consisting of sodium cocoyl lsethionate, glyceryl mono stearate, stearic acid, cocamidopropyl betaine, glycerin, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, disodium EDTA, potassium chloride, starch, aqua and phosphoric acid or combination thereof.
3. The composition as claimed in claim 1, wherein the parabiotic is Lactobacillus ferment.
4. The composition as claimed in claim 3, wherein Lactobacillus ferment is a Lactobacillus sp. ferment adsorbed on a substrate like maltodextrin.
5. The composition as claimed in claim 4, wherein Lactobacillus sp. ferment is in the range of 30% to 50% and maltodextrin is in the range of 50% to 70% by weight of the final Lactobacillus sp. ferment adsorbed on the substrate.
6. The composition as claimed in claim 1, wherein the additional moisturizing ingredient is selected from the group consisting of avocado oil, shea butter, olive oil or ester of olive oil, coco glucoside, glyceryl oleate, sodium L-pyrrolidone carboxylate, aqua, or the like or combinations thereof.
7. The composition as claimed in claim 1, wherein the cosmetically acceptable excipient is selected from a group of consisting of fragrance, fillers or carriers or combination thereof.
8. The composition as claimed in claim 1, wherein the fragrance is present in the range of 0.5% to 1% by weight.
9. The composition as claimed in claim 1, wherein the composition comprises other component.
10. The composition as claimed in claim 9, wherein the other component is selected from a group consisting of surfactants, colorants, emollients, emulsifiers, UV light protection filters, antioxidants, solids and fillers, pearlescing additives, deodorant and antiperspirant active ingredients, insect repellents, care additives and superfatting agents or combination thereof.