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Compositions And Methods For The Treatment Of Eye Disorders

Abstract: Aspects of the present disclosure provide compound of Formula (I) and pharmaceutically acceptable hydrates, solvates, crystals, co-crystals, enantiomers, stereoisomers, polymorphs and prodrugs thereof that can find utility in treatment of eye disorders and complications associated therewith. Aspects of the present disclosure also relate to methods of treating an eye disorder and/or complications thereof in a subject in need thereof by administering the compound of Formula (I) or a pharmaceutically acceptable hydrate, solvate, crystal, enantiomer, stereoisomer, polymorph or prodrug thereof. Formula (I) wherein, X+ represents, Formula (II) or Formula (III).

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
30 April 2020
Publication Number
24/2020
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
docket@khuranaandkhurana.com
Parent Application

Applicants

CELLIX BIO PRIVATE LIMITED
Plot No. 1177 B, Road No. 56, Jubilee Hills, Hyderabad, Telangana 500033

Inventors

1. KANDULA, Mahesh
11-61, G.MEDAPADU, Andhra Pradesh 533434, India.

Specification

1. A compound of formula I:
or a pharmaceutically acceptable hydrate, solvate, crystal, co-crystal, enantiomer, stereoisomer, polymorph or prodrug thereof,
wherein, X+ represents,
for use in treating an eye disorder or complications associated therewith. 2. The compound as claimed in claim 1, which is selected from:

3. The compound as claimed in claim 1, wherein said eye disorder is selected from the group consisting of macular degeneration, cataract, glaucoma, diabetic retinopathy, dry eye, ocular neuritis, retinitis pigmentosa and presbyopia.
4. A pharmaceutical composition for treating an eye disorder or complications thereof, comprising at least one compound as claimed in any one of claims 1 to 2 and a pharmaceutically acceptable excipient.
5. The pharmaceutical composition as claimed in claim 4, wherein said composition is formulated for oral, nasal, topical, rectal, vaginal, aerosol or parenteral administration.

6. The pharmaceutical composition as claimed in claim 4, wherein said composition is a topical ophthalmic formulation.
7. The pharmaceutical composition as claimed in claim 4, wherein said composition is an ophthalmic drop formulation.
8. A method of synthesis of the compound as claimed in claim 1, the method comprising treating pilocarpine with lipoic acid.
9. A method of treating an eye disorder or complications thereof in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of a compound of formula I
or a pharmaceutically acceptable hydrate, solvate, crystal, co-crystal, enantiomer, stereoisomer, polymorph or prodrug thereof,
10. The method as claimed in claim 9, wherein said compound of formula I is selected from:

11. The method as claimed in claim 9, wherein said administering comprises oral, nasal, topical, rectal, vaginal, aerosol or parenteral administration of said compound of formula I.
12. The method as claimed in claim 9, wherein said compound of formula I is administered to said subject in combination with a pharmaceutically acceptable excipient.
13. The method as claimed in claim 9, wherein said compound of formula I is administered topically in a form of an eye drop, a swab, an ointment, a gel or a mist.
14. The method as claimed in claim 9, wherein said compound of formula I is administered topically to at least one eye of said subject.
15. The method as claimed in claim 9, wherein said therapeutically effective amount ranges from 0.001mg to 1000mg.
16. The method as claimed in claim 9, wherein said subject is a human.
17. The method as claimed in claim 9, wherein said eye disorder is selected from the group consisting of macular degeneration, cataract, glaucoma, diabetic retinopathy, dry eye, ocular neuritis, retinitis pigmentosa and presbyopia.
18. Use of a compound as claimed in any of claims 1 to 2 for manufacture of a medicament for treatment of an eye disorder or complications associated therewith.

Documents

Application Documents

# Name Date
1 202047018489-Correspondence to notify the Controller [16-01-2024(online)].pdf 2024-01-16
1 202047018489.pdf 2020-04-30
2 202047018489-STATEMENT OF UNDERTAKING (FORM 3) [30-04-2020(online)].pdf 2020-04-30
2 202047018489-US(14)-ExtendedHearingNotice-(HearingDate-18-01-2024).pdf 2023-11-17
3 202047018489-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [15-11-2023(online)].pdf 2023-11-15
3 202047018489-PROOF OF RIGHT [30-04-2020(online)].pdf 2020-04-30
4 202047018489-US(14)-HearingNotice-(HearingDate-17-11-2023).pdf 2023-10-11
4 202047018489-PRIORITY DOCUMENTS [30-04-2020(online)].pdf 2020-04-30
5 202047018489-POWER OF AUTHORITY [30-04-2020(online)].pdf 2020-04-30
5 202047018489-CLAIMS [13-06-2022(online)].pdf 2022-06-13
6 202047018489-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105) [30-04-2020(online)].pdf 2020-04-30
6 202047018489-CORRESPONDENCE [13-06-2022(online)].pdf 2022-06-13
7 202047018489-FORM FOR SMALL ENTITY(FORM-28) [30-04-2020(online)].pdf 2020-04-30
7 202047018489-FER_SER_REPLY [13-06-2022(online)].pdf 2022-06-13
8 202047018489-FORM 13 [17-02-2022(online)].pdf 2022-02-17
8 202047018489-FORM 1 [30-04-2020(online)].pdf 2020-04-30
9 202047018489-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [30-04-2020(online)].pdf 2020-04-30
9 202047018489-POA [17-02-2022(online)].pdf 2022-02-17
10 202047018489-DECLARATION OF INVENTORSHIP (FORM 5) [30-04-2020(online)].pdf 2020-04-30
10 202047018489-RELEVANT DOCUMENTS [17-02-2022(online)].pdf 2022-02-17
11 202047018489-COMPLETE SPECIFICATION [30-04-2020(online)].pdf 2020-04-30
11 202047018489-FER.pdf 2021-12-23
12 202047018489-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [30-04-2020(online)].pdf 2020-04-30
12 202047018489-FORM 18 [02-11-2021(online)].pdf 2021-11-02
13 202047018489-FORM 3 [24-09-2021(online)].pdf 2021-09-24
13 202047018489-Form26_Power of Attorney_08-06-2020.pdf 2020-06-08
14 202047018489-FORM 3 [26-04-2021(online)].pdf 2021-04-26
14 202047018489-Form1_After Filing_08-06-2020.pdf 2020-06-08
15 202047018489-Correspondence_08-06-2020.pdf 2020-06-08
15 202047018489-FORM 3 [09-09-2020(online)].pdf 2020-09-09
16 202047018489-Correspondence_08-06-2020.pdf 2020-06-08
16 202047018489-FORM 3 [09-09-2020(online)].pdf 2020-09-09
17 202047018489-Form1_After Filing_08-06-2020.pdf 2020-06-08
17 202047018489-FORM 3 [26-04-2021(online)].pdf 2021-04-26
18 202047018489-FORM 3 [24-09-2021(online)].pdf 2021-09-24
18 202047018489-Form26_Power of Attorney_08-06-2020.pdf 2020-06-08
19 202047018489-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [30-04-2020(online)].pdf 2020-04-30
19 202047018489-FORM 18 [02-11-2021(online)].pdf 2021-11-02
20 202047018489-COMPLETE SPECIFICATION [30-04-2020(online)].pdf 2020-04-30
20 202047018489-FER.pdf 2021-12-23
21 202047018489-DECLARATION OF INVENTORSHIP (FORM 5) [30-04-2020(online)].pdf 2020-04-30
21 202047018489-RELEVANT DOCUMENTS [17-02-2022(online)].pdf 2022-02-17
22 202047018489-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [30-04-2020(online)].pdf 2020-04-30
22 202047018489-POA [17-02-2022(online)].pdf 2022-02-17
23 202047018489-FORM 1 [30-04-2020(online)].pdf 2020-04-30
23 202047018489-FORM 13 [17-02-2022(online)].pdf 2022-02-17
24 202047018489-FORM FOR SMALL ENTITY(FORM-28) [30-04-2020(online)].pdf 2020-04-30
24 202047018489-FER_SER_REPLY [13-06-2022(online)].pdf 2022-06-13
25 202047018489-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105) [30-04-2020(online)].pdf 2020-04-30
25 202047018489-CORRESPONDENCE [13-06-2022(online)].pdf 2022-06-13
26 202047018489-POWER OF AUTHORITY [30-04-2020(online)].pdf 2020-04-30
26 202047018489-CLAIMS [13-06-2022(online)].pdf 2022-06-13
27 202047018489-US(14)-HearingNotice-(HearingDate-17-11-2023).pdf 2023-10-11
27 202047018489-PRIORITY DOCUMENTS [30-04-2020(online)].pdf 2020-04-30
28 202047018489-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [15-11-2023(online)].pdf 2023-11-15
28 202047018489-PROOF OF RIGHT [30-04-2020(online)].pdf 2020-04-30
29 202047018489-US(14)-ExtendedHearingNotice-(HearingDate-18-01-2024).pdf 2023-11-17
29 202047018489-STATEMENT OF UNDERTAKING (FORM 3) [30-04-2020(online)].pdf 2020-04-30
30 202047018489.pdf 2020-04-30
30 202047018489-Correspondence to notify the Controller [16-01-2024(online)].pdf 2024-01-16

Search Strategy

1 SearchHistory(6)E_23-12-2021.pdf