Abstract: Aspects of the present disclosure provide compound of Formula (I) and pharmaceutically acceptable hydrates, solvates, crystals, co-crystals, enantiomers, stereoisomers, polymorphs and prodrugs thereof that can find utility in treatment of eye disorders and complications associated therewith. Aspects of the present disclosure also relate to methods of treating an eye disorder and/or complications thereof in a subject in need thereof by administering the compound of Formula (I) or a pharmaceutically acceptable hydrate, solvate, crystal, enantiomer, stereoisomer, polymorph or prodrug thereof. Formula (I) wherein, X+ represents, Formula (II) or Formula (III).
1. A compound of formula I:
or a pharmaceutically acceptable hydrate, solvate, crystal, co-crystal, enantiomer, stereoisomer, polymorph or prodrug thereof,
wherein, X+ represents,
for use in treating an eye disorder or complications associated therewith. 2. The compound as claimed in claim 1, which is selected from:
3. The compound as claimed in claim 1, wherein said eye disorder is selected from the group consisting of macular degeneration, cataract, glaucoma, diabetic retinopathy, dry eye, ocular neuritis, retinitis pigmentosa and presbyopia.
4. A pharmaceutical composition for treating an eye disorder or complications thereof, comprising at least one compound as claimed in any one of claims 1 to 2 and a pharmaceutically acceptable excipient.
5. The pharmaceutical composition as claimed in claim 4, wherein said composition is formulated for oral, nasal, topical, rectal, vaginal, aerosol or parenteral administration.
6. The pharmaceutical composition as claimed in claim 4, wherein said composition is a topical ophthalmic formulation.
7. The pharmaceutical composition as claimed in claim 4, wherein said composition is an ophthalmic drop formulation.
8. A method of synthesis of the compound as claimed in claim 1, the method comprising treating pilocarpine with lipoic acid.
9. A method of treating an eye disorder or complications thereof in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of a compound of formula I
or a pharmaceutically acceptable hydrate, solvate, crystal, co-crystal, enantiomer, stereoisomer, polymorph or prodrug thereof,
10. The method as claimed in claim 9, wherein said compound of formula I is selected from:
11. The method as claimed in claim 9, wherein said administering comprises oral, nasal, topical, rectal, vaginal, aerosol or parenteral administration of said compound of formula I.
12. The method as claimed in claim 9, wherein said compound of formula I is administered to said subject in combination with a pharmaceutically acceptable excipient.
13. The method as claimed in claim 9, wherein said compound of formula I is administered topically in a form of an eye drop, a swab, an ointment, a gel or a mist.
14. The method as claimed in claim 9, wherein said compound of formula I is administered topically to at least one eye of said subject.
15. The method as claimed in claim 9, wherein said therapeutically effective amount ranges from 0.001mg to 1000mg.
16. The method as claimed in claim 9, wherein said subject is a human.
17. The method as claimed in claim 9, wherein said eye disorder is selected from the group consisting of macular degeneration, cataract, glaucoma, diabetic retinopathy, dry eye, ocular neuritis, retinitis pigmentosa and presbyopia.
18. Use of a compound as claimed in any of claims 1 to 2 for manufacture of a medicament for treatment of an eye disorder or complications associated therewith.
| # | Name | Date |
|---|---|---|
| 1 | 202047018489-Correspondence to notify the Controller [16-01-2024(online)].pdf | 2024-01-16 |
| 1 | 202047018489.pdf | 2020-04-30 |
| 2 | 202047018489-STATEMENT OF UNDERTAKING (FORM 3) [30-04-2020(online)].pdf | 2020-04-30 |
| 2 | 202047018489-US(14)-ExtendedHearingNotice-(HearingDate-18-01-2024).pdf | 2023-11-17 |
| 3 | 202047018489-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [15-11-2023(online)].pdf | 2023-11-15 |
| 3 | 202047018489-PROOF OF RIGHT [30-04-2020(online)].pdf | 2020-04-30 |
| 4 | 202047018489-US(14)-HearingNotice-(HearingDate-17-11-2023).pdf | 2023-10-11 |
| 4 | 202047018489-PRIORITY DOCUMENTS [30-04-2020(online)].pdf | 2020-04-30 |
| 5 | 202047018489-POWER OF AUTHORITY [30-04-2020(online)].pdf | 2020-04-30 |
| 5 | 202047018489-CLAIMS [13-06-2022(online)].pdf | 2022-06-13 |
| 6 | 202047018489-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105) [30-04-2020(online)].pdf | 2020-04-30 |
| 6 | 202047018489-CORRESPONDENCE [13-06-2022(online)].pdf | 2022-06-13 |
| 7 | 202047018489-FORM FOR SMALL ENTITY(FORM-28) [30-04-2020(online)].pdf | 2020-04-30 |
| 7 | 202047018489-FER_SER_REPLY [13-06-2022(online)].pdf | 2022-06-13 |
| 8 | 202047018489-FORM 13 [17-02-2022(online)].pdf | 2022-02-17 |
| 8 | 202047018489-FORM 1 [30-04-2020(online)].pdf | 2020-04-30 |
| 9 | 202047018489-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [30-04-2020(online)].pdf | 2020-04-30 |
| 9 | 202047018489-POA [17-02-2022(online)].pdf | 2022-02-17 |
| 10 | 202047018489-DECLARATION OF INVENTORSHIP (FORM 5) [30-04-2020(online)].pdf | 2020-04-30 |
| 10 | 202047018489-RELEVANT DOCUMENTS [17-02-2022(online)].pdf | 2022-02-17 |
| 11 | 202047018489-COMPLETE SPECIFICATION [30-04-2020(online)].pdf | 2020-04-30 |
| 11 | 202047018489-FER.pdf | 2021-12-23 |
| 12 | 202047018489-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [30-04-2020(online)].pdf | 2020-04-30 |
| 12 | 202047018489-FORM 18 [02-11-2021(online)].pdf | 2021-11-02 |
| 13 | 202047018489-FORM 3 [24-09-2021(online)].pdf | 2021-09-24 |
| 13 | 202047018489-Form26_Power of Attorney_08-06-2020.pdf | 2020-06-08 |
| 14 | 202047018489-FORM 3 [26-04-2021(online)].pdf | 2021-04-26 |
| 14 | 202047018489-Form1_After Filing_08-06-2020.pdf | 2020-06-08 |
| 15 | 202047018489-Correspondence_08-06-2020.pdf | 2020-06-08 |
| 15 | 202047018489-FORM 3 [09-09-2020(online)].pdf | 2020-09-09 |
| 16 | 202047018489-Correspondence_08-06-2020.pdf | 2020-06-08 |
| 16 | 202047018489-FORM 3 [09-09-2020(online)].pdf | 2020-09-09 |
| 17 | 202047018489-Form1_After Filing_08-06-2020.pdf | 2020-06-08 |
| 17 | 202047018489-FORM 3 [26-04-2021(online)].pdf | 2021-04-26 |
| 18 | 202047018489-FORM 3 [24-09-2021(online)].pdf | 2021-09-24 |
| 18 | 202047018489-Form26_Power of Attorney_08-06-2020.pdf | 2020-06-08 |
| 19 | 202047018489-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [30-04-2020(online)].pdf | 2020-04-30 |
| 19 | 202047018489-FORM 18 [02-11-2021(online)].pdf | 2021-11-02 |
| 20 | 202047018489-COMPLETE SPECIFICATION [30-04-2020(online)].pdf | 2020-04-30 |
| 20 | 202047018489-FER.pdf | 2021-12-23 |
| 21 | 202047018489-DECLARATION OF INVENTORSHIP (FORM 5) [30-04-2020(online)].pdf | 2020-04-30 |
| 21 | 202047018489-RELEVANT DOCUMENTS [17-02-2022(online)].pdf | 2022-02-17 |
| 22 | 202047018489-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [30-04-2020(online)].pdf | 2020-04-30 |
| 22 | 202047018489-POA [17-02-2022(online)].pdf | 2022-02-17 |
| 23 | 202047018489-FORM 1 [30-04-2020(online)].pdf | 2020-04-30 |
| 23 | 202047018489-FORM 13 [17-02-2022(online)].pdf | 2022-02-17 |
| 24 | 202047018489-FORM FOR SMALL ENTITY(FORM-28) [30-04-2020(online)].pdf | 2020-04-30 |
| 24 | 202047018489-FER_SER_REPLY [13-06-2022(online)].pdf | 2022-06-13 |
| 25 | 202047018489-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105) [30-04-2020(online)].pdf | 2020-04-30 |
| 25 | 202047018489-CORRESPONDENCE [13-06-2022(online)].pdf | 2022-06-13 |
| 26 | 202047018489-POWER OF AUTHORITY [30-04-2020(online)].pdf | 2020-04-30 |
| 26 | 202047018489-CLAIMS [13-06-2022(online)].pdf | 2022-06-13 |
| 27 | 202047018489-US(14)-HearingNotice-(HearingDate-17-11-2023).pdf | 2023-10-11 |
| 27 | 202047018489-PRIORITY DOCUMENTS [30-04-2020(online)].pdf | 2020-04-30 |
| 28 | 202047018489-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [15-11-2023(online)].pdf | 2023-11-15 |
| 28 | 202047018489-PROOF OF RIGHT [30-04-2020(online)].pdf | 2020-04-30 |
| 29 | 202047018489-US(14)-ExtendedHearingNotice-(HearingDate-18-01-2024).pdf | 2023-11-17 |
| 29 | 202047018489-STATEMENT OF UNDERTAKING (FORM 3) [30-04-2020(online)].pdf | 2020-04-30 |
| 30 | 202047018489.pdf | 2020-04-30 |
| 30 | 202047018489-Correspondence to notify the Controller [16-01-2024(online)].pdf | 2024-01-16 |
| 1 | SearchHistory(6)E_23-12-2021.pdf |