DESC:FIELD OF THE INVENTION
[0001] The present disclosure generally relates to the field of herbicides. Particularly, the present disclosure provides a composition comprising a compound [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone; in combination with a compound 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one; and at least one additional herbicide compound for controlling weeds specifically for controlling weeds growing amongst crop plants.

BACKGROUND OF THE INVENTION
[0002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the present invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Various chemical compounds have been developed and used as herbicides for controlling different weeds growing along with crop plants and competing with them and thereby overtaking the crop plants in the field and resulting into loss for farmers. Success of controlling weeds depends upon various factors including mode of action, dose and rate of application of herbicide, specificity of herbicide in controlling particular weeds, mechanism of dissipation herbicide and other factors. To compensate the specificity of the herbicide to control only limited number of species of weeds, loss of herbicide due to dissipation and other such reasons, to improve the weedicide effect, different herbicides are applied simultaneously at much higher rates leading to antagonistic effect of different herbicides when applied together thereby resulting into ineffective weed control, resistance to such herbicides due to their continued application at much higher doses and harmful effects on crop plants leading to loss of crops in the field.
[0004] Therefore, attempts have been made to provide compositions comprising different herbicides to overcome one or more drawbacks mentioned above with the conventional manner of use of different herbicides together at higher rates. However, such attempts have not be successful in providing the effective composition comprising different herbicides. Thus, there still exists an unmet need in the art to provide compositions comprising different herbicides, wherein different herbicides comprised in the composition do not counteract each other’s action but provide synergistic effect, the composition is stable, can minimize or curtail toxic or harmful effect on crop plants, help in reducing the dose and rate of application and effective on array of different weeds.

OBJECTS OF THE INVENTION
[0005] An object of the present disclosure is to provide a composition comprising combination of compounds having synergistic herbicidal effect.
[0006] One object of the present disclosure is to provide a composition comprising herbicides, said composition being stable.
[0007] One object of the present disclosure is to provide a composition comprising herbicide compounds for effective control of wide array of weeds.

SUMMARY OF THE INVENTION
[0008] This summary is provided to introduce a selection of concepts in a simplified form that are further described below in Detailed Description section. This summary is not intended to identify key features or essential features of the subject matter of the present invention, nor is it intended to be used as an aid in determining the scope of the subject matter disclosed herein.
[0009] In a general aspect the present invention provides a composition comprising compounds having synergistic herbicidal effect.
[0010] In one aspect the present disclosure provides a stable composition comprising combination of herbicide compounds.
[0011] In one aspect the present disclosure provides a composition comprising synergistic combination of herbicide compounds for effective control of wide array of weeds.
[0012] In an aspect there is provided a composition comprising a herbicide compound [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone; in combination with a herbicide compound 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one; and at least one additional herbicide compound for controlling wide array of weeds growing amongst crop plants.
[0013] In an aspect, the present invention provides a synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) at least one additional herbicidal compound; and
(d) optionally agriculturally acceptable excipients.
[0014] In one aspect, the at least one additional herbicide to be included in the composition in accordance with the present invention may be selected from the group consisting of but not limited to S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin.
[0015] In another aspect of the present invention, the agriculturally acceptable excipient is selected from wetting agents, dispersing agents, suspending agent, anti-foaming agent, anti-freezing agent, preservatives, thickeners, solvents, emulsifiers, stabilizers, buffering agents, solid carriers, humectants, disintegrating agents, fillers, colorants, fertilizers, surfactants, tackifiers, pH regulators, and a combination thereof.
[0016] In another aspect of the present invention, the [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethyl isoxazol -3-yl sulfone is present in an amount ranges from 0.01 % to 50% by weight of the composition.
[0017] In another aspect of the present invention, the 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one is present in an amount ranges from 0.01 % to 50% by weight of the composition.
[0018] In another aspect of the present invention, the at least one herbicidal compound is present in an amount ranges from 0.01 % to 50% by weight of the composition.
[0019] In another aspect of the present invention, the agriculturally acceptable excipients is present in an amount ranges from 0 % to 80% by weight of the composition.
[0020] In one aspect, the composition comprises effective amount of herbicide compounds for exhibiting herbicidal activity. The concentration of the compound [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone ranges from about 0.01% to about 50% by weight of the composition. The concentration of the compound 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one ranges from about 0.01% about 50% by weight of the composition. The concentration of at least one additional compound can range from about 0.01% to about 50% by weight of the composition.
[0021] In another aspect of the present invention, the composition comprises:
(a) 0.01 % to 50% [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone by weight of the composition;
(b) 0.01 % to 50% 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one by weight of the composition;
(c) 0.01 % to 50% at least one herbicidal compound selected from the group consisting of S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin by weight of the composition; and
(d) 0 % to 80% agriculturally acceptable excipients by weight of the composition.
[0022] In another aspect of the present invention, the composition comprises:
(a) 2.5% to 20% [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone by weight of the composition;
(b) 4% to 50% 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one by weight of the composition;
(c) 1 % to 50% at least one herbicidal compound selected from the group consisting of S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin by weight of the composition; and
(d) 10% to 80% agriculturally acceptable excipients by weight of the composition.
[0023] In yet another aspect of the present invention, the composition is in the form of capsule suspension (CS), dispersible concentrate (DC), emulsifiable concentrate (EC), emulsion, water in oil (EO), emulsion, oil in water (EW), jambo balls or bags (bags in water soluble pouch), micro-emulsion (ME), oil dispersion (OD), oil miscible flowable concentrate (oil miscible suspension) (OF), oil miscible liquid (OL), suspension concentrate (SC), suspo-emulsion (SE), soluble concentrate (SL), water dispersible granule (WDG), wettable granule (WG), water soluble granule (SG), water soluble powder (SP), wettable powder (WP), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), and Controlled release granules (CR).
[0024] In yet another aspect of the present invention, the composition is in the form of suspo-emulsion (SE), suspension concentrate (SC), and wettable granule (WG).
[0025] In yet another aspect, the present invention relates to a synergistic herbicide composition for use in controlling weeds growing amongst crop plants.
[0026] In yet another aspect, the present invention relates to a method of controlling weeds growing amongst crop plants by application of an effective amount of a composition of the present invention.
[0027] Other aspects of the invention will be set forth in the description which follows, and in part will be apparent from the description, or may be learnt by the practice of the invention.

DETAILED DESCRIPTION OF THE INVENTION
[0028] The following is a detailed description of embodiments of the disclosure. The embodiments are in such detail as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the scope of the present disclosure.
[0029] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.
[0030] Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
[0031] In some embodiments, numbers have been used for quantifying weights, percentages, ratios, and so forth, to describe certain embodiments of the invention and are to be understood as being modified in some instances by the term “about.” The term “about” when used in conjunction with any figure would mean + 10% of said figure. Accordingly, in some embodiments, the numerical parameters set forth in the written description are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
[0032] Various terms as used herein are shown below. To the extent a term used is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.
[0033] As used in the description herein that follow, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise.
[0034] Unless the context requires otherwise, throughout the specification which follow, the word “comprise” and variations thereof, such as, “comprises” and “comprising” are to be construed in an open, inclusive sense that is as “including, but not limited to.”
[0035] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein.
[0036] All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g. “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention.
[0037] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is herein deemed to contain the group as modified.
[0038] The description that follows, and the embodiments described therein, is provided by way of illustration of an example, or examples, of particular embodiments of the principles and aspects of the present disclosure. These examples are provided for the purposes of explanation, and not of limitation, of those principles and of the disclosure.
[0039] It should also be appreciated that the present disclosure can be implemented in numerous ways, including as a composition, a formulation, a kit comprising the herbicide compounds or composition or formulations thereof, a method of applying the compositions or formulation provided in accordance with the present invention for controlling weeds.
[0040] The following disclosure provides many exemplary embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus, if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.
[0041] As described herein, the term ‘effective amount of’ is used to imply the amount of the herbicide compound used in the composition or the amount of composition or the amount of formulation in accordance with the present invention that is necessary for the elimination, prevention or curb of growth of unwanted or undesired plants and vegetation referred as weeds without causing harmful effect to crop plants. The effective amount may be dependent on the time, soil, target weeds, crops and environmental conditions at the time of application.
[0042] The present invention relates to a composition comprising synergistic combination of herbicide compounds for effective control of wide array of weeds.
[0043] In one embodiment of the present invention there is provided a composition comprising a herbicide compound [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone; in combination with a herbicide compound 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one; and at least one additional herbicide compound for controlling wide array of weeds growing amongst crop plants.
[0044] The herbicide compound [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone, commonly known as Pyroxasulfone, used as one of the active ingredients in the composition of the present invention is a compound belonging to the N-phenylphthalimide class of chemical compounds. It is a pre-emergence grass and broad-leaved weed herbicide and has code ‘K3’as per Herbicide Resistance Action Committee (HRAC). It’s weedicidal property is due to the inhibition of very long-chain fatty acid synthesis. It has the structure as per Formula I:

Formula I
[0045] The herbicide compound 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one, commonly known as Metribuzin, is a member of the class of 1,2,4-triazines. It is a pre and post-emergence herbicide that inhibits photosynthesis at PS II of the target plants and is thus categorized under code ‘C1’ by the HRAC. It has the structure as per Formula II:

Formula II
[0046] In one embodiment, the additional herbicide to be included in the composition in accordance with the present invention can be selected from the group consisting of but not limiting to ametryn, diuron, atrazine, s-metolachlor, mesotrione, prosulfocarb, pendimethalin, topramezone, isoxaflutole, flufenacet, flumioxazin, tolpyralate, tembotrione, salt of 2,4-D, trifludimoxazin, bicyclopyrone, sulcotrione, and sulfentrazone.
[0047] Ametyn is a triazine herbicide used to control most annual and broad-leaved weeds and is categorized under code ‘C1’ by the HRAC.
[0048] Diuron is a substituted urea herbicide used to control annual and perennial broadleaf and grassy weeds. Diuron works by inhibiting photosynthesis. It belongs to group ‘C2’ as classified by HRAC.
[0049] Atrazine is a selective triazine herbicide used to control broadleaf and grassy weeds. It’s mechanism of action is by inhibition of photosynthesis at photosystem II. It belongs to group ‘C1’ as classified by HRAC.
[0050] S-metolachlor is a preemergent herbicide used for the control of annual grasses and small-seeded broadleaf weeds. As per HRAC classification, it is categorized under class K3.
[0051] Mesotrione pre-emergence and post-emergence herbicide used to control some grass and broad-leaved weeds. It belongs to class “F2” as per HRAC classification.
[0052] Prosulfocarb is a thiocarbamate herbicide used for controlling grass and broadleaf weeds. It belongs to group ‘N’ as per HRAC classification.
[0053] Pendimethalin is an herbicide of the dinitroaniline class used in premergence and postemergence applications to control annual grasses and certain broadleaf weeds. It belongs to group ‘K1’ as classified by HRAC.
[0054] Topramezone, is a herbicide, which belongs to the class of pyrazolones or benzoylpyrazoles. It can be used to control broad leaved weeds and grass weeds. It belongs to the group ‘A’ of the HRAC classification system.
[0055] Isoxaflutole is a member of the class of isoxazoles used for control of certain broadleaf and grass weeds. It belongs to group ‘F2’ as classified by HRAC.
[0056] Flufenacet is an oxyacetamide herbicide used to control grasses and some broad-leaved weeds. It belongs to group ‘K3’ as classified by HRAC.
[0057] Flumioxazin is a N-phenylimide herbicide used for control of grass weeds. It belongs to group ‘E’ as classified by HRAC.
[0058] Tolpyralate belongs to hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor class of herbicide. It is placed in group ‘F2’ by HRAC. It is used for control of grass and broad-leaved weeds.
[0059] Tembotrione is a triketone group herbicide. It belongs to group ‘F2’ as classified by HRAC. It is used for the control of broad-leaved and grassy weeds.
[0060] Salt of 2,4-D is a translocated phenoxy herbicide. It belongs to group ‘O’ as classified by HRAC. It is used against broad-leaved weeds and evasive weeds in aquatic situations.
[0061] Trifludimoxazin is a member of the class of 1,3,5-triazinanes. It belongs to group ‘G’ as classified by HRAC. It is used for controlling broadleaf and grass weeds.
[0062] Bicyclopyrone belongs to hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor class of herbicide. It is placed in HRAC group ‘F2’. It is used for controlling broadleaf and grass weeds.
[0063] Sulcotrione is a ß-triketone herbicide. It belongs to group ‘F2’ as classified by HRAC. It is used for controlling grass and broad-leaved weeds.
[0064] Sulfentrazone is a member of the class of triazoles that is 5-oxo-1,2,4-triazole. It belongs to group ‘E’ as classified by HRAC. It is used as a herbicide to control broad-leaved weeds.
[0065] The individual herbicides belonging to different class of chemicals and HRAC mostly are suitable for controlling limited species of weeds growing with only few crops like soybean, maize, sugarcane, and few others. Surprisingly the composition comprising combination of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone; 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one and at least one additional herbicide selected from ametryn, diuron, atrazine, s-metolachlor, mesotrione, prosulfocarb, pendimethalin, topramezone, isoxaflutole, flufenacet, flumioxazin, tolpyralate, tembotrione, salt of 2,4-D, trifludimoxazin, bicyclopyrone, sulcotrione, and sulfentrazone act synergistically that can control array of diverse weeds growing amongst large number of crop plants.
[0066] In one embodiment the composition comprises effective amount of herbicide compounds for exhibiting synergistic herbicidal activity on wide array of weeds.
[0067] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) at least one additional herbicidal compound is selected from the group consisting of S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin; and
(d) optionally agriculturally acceptable excipients.
[0068] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of S-metolachlor; and
(d) optionally agriculturally acceptable excipients.
[0069] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of topramezone; and
(d) optionally agriculturally acceptable excipients.
[0070] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of sulfentrazone; and
(d) optionally agriculturally acceptable excipients.
[0071] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of isoxaflutole; and
(d) optionally agriculturally acceptable excipients.
[0072] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of sulcotrione; and
(d) optionally agriculturally acceptable excipients.
[0073] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of ametryn; and
(d) optionally agriculturally acceptable excipients.
[0074] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of atrazine; and
(d) optionally agriculturally acceptable excipients.
[0075] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin; and
(d) optionally agriculturally acceptable excipients.
[0076] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of mesotrione; and
(d) optionally agriculturally acceptable excipients.
[0077] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of tembotrione; and
(d) optionally agriculturally acceptable excipients.
[0078] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of flumioxazin; and
(d) optionally agriculturally acceptable excipients.
[0079] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of trifludimoxazin; and
(d) optionally agriculturally acceptable excipients.
[0080] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of 2,4-D salt; and
(d) optionally agriculturally acceptable excipients.
[0081] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of prosulfocarb; and
(d) optionally agriculturally acceptable excipients
[0082] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of bicyclopyrone; and
(d) optionally agriculturally acceptable excipients.
[0083] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of tolpyralate; and
(d) optionally agriculturally acceptable excipients.
[0084] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of pendimethalin; and
(d) optionally agriculturally acceptable excipients.
[0085] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of flufenacet; and
(d) optionally agriculturally acceptable excipients.
[0086] In another embodiment of the present invention, the synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) effective amount of flumioxazin; and
(d) optionally agriculturally acceptable excipients.
[0087] In one embodiment, the concentration of the compound [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone ranges from about 0.01% to about 50% by weight of the composition. Preferably in the ranges from 2.5% to 10%, from 2.5% to 15%, from 2.5% to 20%, from 2.5% to 25%, from 2.5% to 30%, from 2.5% to 35%, from 2.5% to 40% and from 2.5% to 50% by weight of the composition.
[0088] In one embodiment, the concentration of the compound 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one ranges from about 0.01% about 50% by weight of the composition. Preferably in the ranges from 4% to 10%, from 4% to 15%, from 4% to 20%, from 4% to 25%, from 4% to 30%, from 4% to 35%, from 4% to 40% and from 4% to 50% by weight of the composition.
[0089] In one embodiment, the concentration of at least one additional compound can range from about 0.01% to about 50% by weight of the composition.
[0090] In one embodiment, the concentration of the compound, S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin can range from 0.01% to about 50% by weight of the composition.
[0091] In certain embodiment, the present invention relates to synergistic herbicide SE formulation comprising combination of:
(a) 2.5% [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone by weight of the composition;
(b) 4% 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one by weight of the composition;
(c) 20 % additional herbicidal compound; and
(d) 73.5% agriculturally acceptable excipients;
wherein the additional herbicidal compound is S-metolachlor and pendimethalin.
[0092] In certain embodiment, the present invention relates to synergistic herbicide WG formulation comprising combination of:
(a) 4% to 15% [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone by weight of the composition;
(b) 15% to 40% 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one by weight of the composition;
(c) 10 % to 40% additional herbicidal compound by weight of the composition; and
(d) 5% to 71% agriculturally acceptable excipients by weight of the composition;
wherein the additional herbicidal compound is flufenacet, flumioxazin, isoxaflutole, sulfentrazone, or atrazine.
[0093] In certain embodiment, the present invention relates to synergistic herbicide SC formulation comprising combination of:
(a) 4% [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone by weight of the composition;
(b) 16% 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one by weight of the composition;
(c) 1 % to 3% additional herbicidal compound by weight of the composition; and
(d) 77% to 79% agriculturally acceptable excipients by weight of the composition;
wherein the additional herbicidal compound is topramezone, mesotrione, or tembotrione.
[0094] In one embodiment, the agriculturally acceptable excipient is selected from wetting agents, dispersing agents, suspending agent, anti-foaming agent, anti-freezing agent, preservatives, thickeners, solvents, emulsifiers, stabilizers, buffering agents, solid carriers, humectants, disintegrating agents, fillers, colorants, fertilizers, surfactants, tackifiers, pH regulators, and a combination thereof.
[0095] In one embodiment of the present invention, the wetting agent is selected from ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, organosilicons surfactants (as a wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.
[0096] According to the present invention, the dispersing agent can be a conventionally available for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylic polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymers and mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof. The examples of dispersing agents are alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium salt of alkyl naphthalene sulfonate, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide. In one embodiment the dispersing agent is selected from naphthalenesulfonic acid, sodium salt condensated with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide and the like.
[0097] In one embodiment of the present invention, the suspending agent is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay and the like.
[0098] In one embodiment of the present invention, the anti-foaming agent is selected from silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane and the like.
[0099] In one embodiment of the present invention, the anti-freezing agent is selected from ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride and the like.
[00100] In certain embodiment of the present invention, the preservative is selected from 1,2-benzisothiazolin-3(2H)-one, sodium salt, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one, propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, para hydroxy benzoates or mixtures thereof and the like.
[00101] In another embodiment of the present invention, the thickeners is selected from xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch and the like. The thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and 15 seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl 20 alcohol and polyethylene oxide or mixtures.
[00102] In one embodiment of the present invention, the solvent is selected from includes water, water soluble alcohols and dihydroxy alcohol ethers. Water soluble alcohol or lower alcohol (1-4 carbon atoms) includes-methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol. Macromolecular alcohol includes polyethylene glycol, sorbitol, glucitol etc., dihydroxy alcohol ethers includes dihydroxy alcohol alkyl ether or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, di-propylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, di-propylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, di-propylene glycol phenyl ether, and the like. Any of the mentioned solvent can be used either alone or in combinations thereof. Paraffinic hydrocarbons, cyclohexanone, isophorone and ester solvents such as methyloleate, dimethylamide and morpholineamide derivatives of C6-C16 fatty acids, and mono-alkylene carbonates such as ethylene carbonate, propylene carbonate and butylene carbonates, dimethylsulfoxide (DMSO), 2-ethylhexanol and n-butanol, n-alkylpyrrolidones, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic hydrocarbons and/or aliphatic hydrocarbons, one or more dimethylamides, such as C8-dimethylamide, C10-dimethylamide, C12-dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycols, aromatic hydrocarbons, methylpyrrolidinone (NMP); dimethylformamide (DMF); dimethylisosorbide (DMI); isophorone; acetophenone; 1,3-dimethyl-2-imidazolidonone; lactate esters; dimethyl and diethylcarbonates; alcohols including methanol; ethanol; iso-propanol; n-propanol; n-butanol; iso-butanol; and tert-butanol; Methyl L-lactate, 2-Ethylhexyl L-lactate, Ethyl L-lactate, n-Butyl L-lactate, Octyl phenyl ethoxylates.
[00103] In one embodiment of the present invention, the emulsifiers is selected from the emulsifiers containing salts of dodecylbenzene sulphonate, e.g. Ca-salts or amine salts, and sulphonates of other C11-C16 alkylbenzenes, alkylether sulphates, alkylphenoletherphosphates and ester phosphates; non-ionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, e.g. ethoxylated castor oil, fatty acid esters, e.g. of sorbitol, and their ethoxylated derivatives, ethoxylated amines, and condensates of glycerol; and catanionic emulsifiers such as a cationic amine, optionally in combination with an alkylsulphonate or ether sulphonate or ether phosphate, alkoxylated alcohols; alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; ethoxylated tristyrylphenol; fatty acid esters of sorbitol and ethoxylated derivatives thereof; ethoxylated amines and condensates of glycerol; sulfonated alkylbenzenes in the range C11-C16 and salts thereof; alkylether sulphates; alkyletherphosphates; alkylphenoletherphosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulphated ethers of ethoxylated tristyrylphenol; or a catanionic system, wherein a cationic amine is present in combination with an alkylsulphonate, an alkylethersulphonate, an ether sulphate, or an ether phosphate such as an alkyletherphosphate, nonylphenol polyethoxy ethanols, castor oil polyglycol ethers, polyadducts of ethylene oxide and polypropylene, tributyl phenoxy polyethoxy ethanol, octyl phenoxy polyethoxy ethanol.
[00104] Various embodiments of the present invention, the stabilizer can be selected from butylated hydroxytoluene (BHT), epoxidized soybean oil (ESBO), Epichlorhydrin and the like.
[00105] In one embodiment of the present invention, the buffering agent is selected from group consisting of calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.
[00106] In another embodiment of the present invention, the solid carrier is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.
[00107] In another embodiment of the present invention, the disintegrating agent is selected from citric acid, succinic acid, sodium bicarbonate and the like
[00108] In another embodiment of the present invention, the preservative is selected from the group consisting of propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2- methyl-4-isothiazolin-3-one, potassium sorbate, para hydroxy benzoates or mixtures thereof.
[00109] In an embodiment of the present invention, the humectant is selected from the group consisting of urea, humic acid, glycerol, lactose and the like.
[00110] The composition of the present invention comprises active ingredients having synergistic activity thereby reducing the dose of individual ingredients or of the combination as such. Consequently, the same also helps to reduce the number of applications and duration of application of composition.
[00111] In an embodiment, the herbicidal composition can control and shows broad spectrum activity and upto 99% reduction in weeds. In an embodiment, the herbicidal composition shows at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95% or at least 99% reduction in weeds.
[00112] In an embodiment, the composition may be used for the control of the growth, proliferation or germination of weeds.
[00113] In an embodiment, the composition of present disclosure can be used to control all kind of monocots, dicots, sedges weeds or any undesired or harmful plants. The composition can also control annual and perennial weeds. The most common weeds controlled by the composition include, but are not limited to, Abutilon indicum, Acalypha indica, Acanthospermum hispidum, Achyranthes aspera, Aerva tomentosa, Ageratum conyzoides, Alhagi camelorum, Amaranthus hybridus, Amaranthus spinosus, Amaranthus viridis, Ammannia baccifera, Anagallis arvensis, Argemone mexicana, Artemisia nilagiricia, Asphodelus tenuifolius, Avena fatua, Avena ludoviciana, Bidens pilosa, Boerhaavia diffusa, Boerhavia repanda, Brachiaria mutica, Brassica kaber, Bromus tectorum, Calotropis gigantea, Cannabis sativa, Carthamus axyacantha, Cassia tora, Celosia argentea, Centella asiatica, Chenopodium album, Chenopodium murale, Chloris barbata, Chrozophora rottlerii, Cichorium intybus, Cirsium arvense, Clitoria ternatea, Cnicus arvensis, Commelina benghalensis, Commelina communis, Convolvulus arvensis, Conyza canadensis, Corchorus acutangulus, Coronopus didymus, Crotalaria serice, Cucumis callosus, Cuscuta campestris, Cuscuta chinensis, Cynodon dactylon, Cyanotis axillaris, Cyperus esculenthus, Cyperus iria, Cyperus rotundus, Dactyloctenium aegyptium, Datura stramonium, Daucus carota, Digera arvensis, Digitaria sanguinalis, Dinebra retroflexa, Echinochola colonum, Echinochola crusgalli, Eclipta alba, Eichhornia crassipes, Elephantopus scaber, Eleusine indica, Eragrostis major, Euphorbia geniculata, Euphorbia hirta, Fimbristylis miliacea, Fumaria indica, Gynandropsis gynandra, Heliotropium indicum, Indigofera glandulosa, Ipomea aquatica, Lantana camara, Lathyrus aphaca, Launaea asplenifolia, Launaea nudicaulis, Leucas aspera, Ludwigia parviflora, Marsilea quadrifoliata, Medicago denticulate, Mimosa pudica, Melilotus alba, Melilotus indica, Ocimum canum, Oenothera biennis, Opuntia dillenil, Orobanche ramosa, Oryza longistaminata, Oryza sativa, Oxalis corniculata, Oxalis latifolia, Parthenium hysterophorus, Paspalum sanguinale, Phalaris minor, Phyllanthus niruri, Physalis minima, Polypogon monspeliensis, Portulaca oleracea, Prosopis juliflora, Rumex dentatus, Saccharum spontaneum, Stearia glauca, Seteria viridis, Sida spinosa, Silene antirrhina, Sisymbrium irio, Solanum nigrum, Solanum surattense, Sonchus oleraceous, Sorghum halepense, Spergula arvensis, Sphenocleazeylanica Gaertn, Striga asiatica, Tagetes minuta, Trianthema monogyna, Trianthema portulacastrum, Tribulus terrestris, Trigonelia polycerata, Vernonia cinerea, Vicia sativa and Xanthium strumarium.
[00114] The composition in accordance with the present invention can be used to control harmful plants that are difficult to control and that sprout from rhizomes, rhizomes or other permanent organs.
[00115] The composition in accordance with the present invention can be used to control wide array of weeds in non-cultivated areas, on paths, track systems, industrial areas ("industrial weed control") or the like.
[00116] In an embodiment, the composition of the present invention may be used to control the target weeds among the field GMO (Genetically Modified Organism) and Non GMO varieties of including but not limited to, Cotton (Gossypium spp.),Paddy (Oryza sativa), Wheat (Triticumaestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor),Oat (Avena sativa), Pearl millet (Pennisetum glaucum),Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linumusitatissimum), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus), Onion (Allium cepa L.),Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum), Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapasubsprapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander(Coriandrum sativum), Ajwain (Trachyspermumammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold (Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera (Gerbera jamesonii), Carnation (Dianthus caryophyllus), and the like.
[00117] In one embodiment the composition can be used to control weeds growing along with crops that have become tolerant to herbicides or classes of herbicides by conventional breeding or genetic engineering methods.
[00118] In one embodiment the composition can be used in known plant crops or tolerant crop plants which are still to be developed, are modified by conventional mutagenesis or are genetically modified for any property in comparison to previously occurring plants.
[00119] In an embodiment, the composition of the present invention can be used to delay, reduce and/or avoid the onset of herbicidal resistance.
[00120] In an embodiment, the composition of the present invention can be used to control unwanted vegetation in plantation crops, orchards, fallow lands, water bodies, field bunds, and the like
[00121] The composition of the present invention may also comprise other active ingredients selected from but not limiting to insecticides, fungicides, pesticides, safeners, fertilizers, growth regulators, and the like and/or combinations thereof. The composition content of these additives is not particularly limiting and may be determined by a skilled technician in the art according to the conventional protocols.
[00122] In an embodiment, the composition of the present invention may be formulated into formulation including a solid, liquid or semi-solid formulation.
[00123] In an embodiment, the formulation may be selected from the group comprising of capsule suspension (CS), dispersible concentrate (DC), emulsifiable concentrate (EC), emulsion, water in oil (EO), emulsion, oil in water (EW), jambo balls or bags (bags in water soluble pouch), micro-emulsion (ME), oil dispersion (OD), oil miscible flowable concentrate (oil miscible suspension) (OF), oil miscible liquid (OL), suspension concentrate (SC), suspo-emulsion (SE), soluble concentrate (SL), water dispersible granule (WG or WDG), water soluble granule (SG), water soluble powder (SP), wettable powder (WP), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), granule (GR), soil applied granules (SAG), controlled release granules (CR), dusts, spray powders or the like
[00124] In a preferred embodiment of the present invention, the composition is in the form of suspo-emulsion (SE), suspension concentrate (SC), and wettable granule (WG).
[00125] In an embodiment, the present disclosure relates to a process of preparing the composition of the present invention or formulation comprising the composition of the present invention.
[00126] In an embodiment, the process may comprise the steps of milling, blending, drying, packaging, combinations thereof and the like.
[00127] In an embodiment, the process of preparation of suspo-emulsion (SE) formulation comprises the step of:
Preparation SC Premix:
Step 1: Preparation of 2% Gum Solution:
Charging thickener and preservative into water and homogenizing the mixture to obtain 2% gum solution. This solution should be prepared 12-18 hours prior to use.
Step 2-Charging DM water (25.7 liter), anti-freezing agent and humectant into designated vessel and mixed thoroughly.
Step 3-Adding suspending agent, wetting agent, dispersing agent and anti-foaming into the vessel having water and homogenise the contents for 45 to 60 minutes using high shear homogeniser.
Step 4- Adding pyroxasulfone and Metribuzin to the premix slowly and homogenised to get uniform slurry ready for grinding.
Step 5-Before grinding half the quantity of antifoam was added and then material was subjected to grinding in mill till desired particle size is achieved.
Step 6-Add remaining antifoaming agent after grinding process completes and before sampling for in process analysis.
Preparation of EC Premix:
Step 7-Charging the additional herbicide into aromatic solvent and heated at 60 degree Celsius and now added another dispersing agent and emulsifier and mixed properly.
Preparation of SE Formulation:
Step 8- Mixing SC and EC premix slowly into other vessel
Step 9-Finally adding 2% gum solution to this formulation and send to QC for quality check.
[00128] In an embodiment, the process of preparation of suspension concentrate (SC) formulation comprises the step of:
Step 1-2% Gum Solution: Charging thickener and preservative into water and homogenizing the mixture to obtain 2% gum solution. This solution should be prepared 12-18 hours prior to use.
Step 2- Charging DM water (25.7 liter), anti-freezing agent and humectant into designated vessel and mixed thoroughly.
Step 3-Adding suspending agent, wetting agent, dispersing agent and anti-foaming into the vessel having water and homogenise the contents for 45 to 60 minutes using high shear homogeniser.
Step 4- Adding pyroxasulfone, Metribuzin and additional herbicide to the premix slowly and homogenised to get uniform slurry ready for grinding.
Step 5-Before grinding half the quantity of antifoam was added and then material was subjected to grinding in mill till desired particle size is achieved.
Step 6-Add remaining antifoaming agent after grinding process completes and before sampling for in process analysis.
Step 7-Finally adding the 2% gum solution to this formulation and send to QC for quality check.
[00129] In an embodiment, the process of preparation of Wettable Granule (WG) formulation comprises the steps of:
Step 1-Charging the carriers, humectant, anti-foaming agent, wetting agent, dispersing agent, and co-dispersing agent into a ribbon or premix blender and homogenization for 30 minutes.
Step 2- Charge Pyroxasulfone Metribuzin technical (20 kg) and additional herbicide and again homogenized for 30 minutes and now this pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender for approx. 90 minutes till it becomes homogeneous.
Step 3-Finely grinded powder is mixed with DM water having anti-foaming agent to form extrudable dough.
Step 4-Dough is passed through extruder to get granules of required size.
Step 5-Wet granules are passed through fluidized bed drier to remove extra water and further graded using vibrating screens.
Step 6-Final product is sent for QC approval.
Step 7-After approval material is packed in required pack sizes.
[00130] In another embodiment, the present disclosure relates to a method of controlling growth of undesired plants by application of a herbicidally effective amount of an composition of the present invention or formulation comprising the same.
[00131] In still another embodiment, the present disclosure relates to a method of preventing undesired plants from infecting crops by applying a herbicidally effective amount of the composition of the present invention or formulation comprising the same.
[00132] In yet another embodiment, the present disclosure relates to use of the composition of the present invention or formulation comprising the same on unwanted vegetation or plants.
[00133] The formulations present in the commercial form for example wettable powders, emulsifiable concentrates, dispersions and water-dispersible granules using water for use are optionally diluted in the customary manner with water or other inert substance before use. The manner of use can include mixing the formulation together with water in the tank and the spray mixture, application before or after sowing, apply to the open furrow in which the seeds have been sown, seed dressing or treatment of the germinated seedlings.
[00134] The composition of the present invention as such or formulation comprising the same can be applied to the plants (for example harmful plants such as mono- or dicotyledon weeds or undesired crop plants), the seeds (for example grains, seeds or vegetative propagation organs such as tubers or shoot parts with buds) or the area on which the plants grow (for example the area under cultivation).
[00135] The composition of the present invention as such or formulation comprising the same can be applied in the pre-sowing (possibly also by incorporation into the soil), pre-emergence or post-emergence methods. Preference is given to use in the early post-sowing pre-emergence process or in the post-emergence process of plantation crops against harmful plants which have not yet emerged or have already emerged. The application can also be integrated into weed management systems, with shared multiple applications for example sequential applications.
[00136] In an embodiment, the composition or formulation in accordance with the present disclosure may be applied via tank mix method or sequential application. The composition may be used pre-emergence or post-emergence of undesired plants. It may be applied on the locus of the plant, including all plant parts, or on the soil or turf of growth. It may be applied before or after the crop seeds are planted.
[00137] In an embodiment, the composition lowers the application rate of active compounds on the undesired plants based on the formulation the way of application may be selected from spraying, dusting, scattering, soaking and the like.
[00138] In an embodiment, the composition or formulation comprising the same slows down the growth or kills the undesired plants. The herbicide compounds comprised in the composition in synergistic manner intervene the undesired plant's own metabolism and can thus be used to influence plant constituents in a targeted manner and to facilitate the harvest, e.g. by triggering desiccation and stunted growth. Furthermore, they are also suitable for general control and inhibition of undesirable vegetative growth without killing the plants, which can play an important role in many monocotyledonous and dicotyledon crops, as this can reduce or completely prevent storage.
EXAMPLES
[00139] The present invention is further explained in the form of following examples. However, it is to be understood that the following examples are merely illustrative and are not to be taken as limitations upon the scope of the invention.
[00140] Example 1: Pyroxasulfone 2.5%+Metribuzin 4%+S-metolachlor 20% SE (Suspo Emulsion)
Ingredients Percent (w/w) Function
Pyroxasulfone a.i. 2.50 Active Ingredient
Metribuzin a.i. 4.00 Active Ingredient
S-metolachlor a.i. 20.00 Active Ingredient
Urea 5.00 Humectant
Octyl phenol ethoxylate 10.00 Solvent
Aromatic solvent 10.00 Co-Solvent
Castor oil ethoxylate 40 moles 5.00 Emulsifier
Copolymer butanol EO/PO 1.50 Wetting agent
Acrylic graft copolymer 2.00 Dispersing agent 1
Tri-styryl phenol with 16 moles EO 3.00 Dispersing agent 2
Attapulgite clay 1.00 Suspending agent
Polydimethyl siloxane 0.30 Antifoaming agent
1,2- benzisothiazoline-3-one 0.15 Preservative
1,2-Propylene glycol 5.00 Antifreezing agent
Xanthan gum 0.15 Thickner
Water 30.40 Diluent Water
Total 100.00

Manufacturing process of Pyroxasulfone 2.5%+Metribuzin 4%+S-metolachlor 20% SE (Suspo Emulsion)
[00141] Preparation of SC Premix
Step 1: Preparation of 2% Gum Solution: Charged Xanthan gum (2 kg) and 1,2-benzisothiazoline-3-one (2 kg) into 96 kg water and homogenized. The gum solution was made 12-18 hours prior to use.
Step 2-Charged DM water (25.7 liter), 1,2-propylene glycol (5 kg) and urea (5 kg) into designated vessel and mixed thoroughly.
Step 3-Added attapulgite clay (1 kg), copolymer butanol EO/PO (1.5 kg), acrylic graft copolymer (2 kg) and polydimethylsiloxane (0.15 kg) into the vessel having water and homogenized the contents for 45 to 60 minutes using high shear homogenizer.
Step 4-Added pyroxasulfone technical (2.5 kg) and metribuzin technical (4 kg) to this premix slowly and homogenized to get uniform slurry ready for grinding.
Step 5-Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6-Added remaining polydimethyl siloxane (0.15 kg) and antifoam was added after grinding process completed and before sampling for in process analysis.
[00142] Preparation of EC Premix
Step 7-Charged S-metolachlor technical (20 kg) into aromatic solvent (10 kg) and Octyl phenol ethoxylate (10 kg) and heated at 60 degree celsius and then added Tri-styryl phenol with 16 moles of EO (3 kg) and castor oil ethoxylate 40 moles (5kg) and mixed properly.
[00143] Preparation of SE Formulation
Step 8-Mixed the SC and EC premix slowly into other vessel.
Step 9-Finally added the 2% gum solution (5.0 kg) to this mixture to obtain SE formulation and sent to QC for quality check.
[00144] Storage stability results:
Laboratory storage for 14 days
Parameters Specification (in house) Initial at 54±2 ?C at 0±2 ?C
Pyroxasulfone content percent by mass 2.375 to 2.75 2.70 2.55 2.65
Metribuzin content percent by mass 3.80 to 4.40 4.30 4.10 4.20
S-metolachlor content percent by mass 19.0 to 21.0 21.00 20.40 20.85
Pyroxasulfone suspensibility percent min. 80 97.50 96.50 97.30
Metribuzin suspesnibility precent min. 80 98.50 97.50 98.30
S-metolachlor suspesnibility precent min. 80 98.50 97.70 98.40
pH range (1% aq. Suspension) 7.0 to 10.0 7.25 7.35 7.25
Pourability 95% min. 98.00 97.10 97.20
Specific gravity 1.00-1.10 1.05 1.05 1.05
Viscosity at spindle no. 62, 20 rpm 350-800 cps 650 660 675
Particle size (micron) D50<3, D90<10 2.2,8.6 2.4,8.8 2.5,8.9
Persistent foam ml (after 1 minute) max. 60 nil 3 nil
Room temperature storage
Parameters Specification (in house) 1 month 6 months 12 months
Pyroxasulfone content percent by mass 2.375 to 2.75 2.70 2.65 2.60
Metribuzin content percent by mass 3.80 to 4.40 4.30 4.20 4.10
S-metolachlor content percent by mass 19.0 to 21.0 21.00 20.80 20.40
Pyroxasulfone suspensibility percent min. 80 97.50 96.50 97.30
Metribuzin suspesnibility precent min. 80 98.50 97.50 98.30
S-metolachlor suspesnibility precent min. 80 98.50 97.70 98.40
pH range (1% aq. Suspension) 7.0 to 10.0 7.25 7.35 7.25
Pourability 95% min. 98.00 97.50 97.00
Specific gravity 1.00-1.10 1.05 1.05 1.05
Viscosity at spindle no. 62, 20 rpm 350-800 cps 650 660 675
Particle size (micron) D50<3, D90<10 2.2,8.6 2.4,8.8 2.5,8.9
Persistent foam ml (after 1 minute) max. 60 nil 3 nil

[00145] Example 2: Pyroxasulfone 4%+Metribuzin 16%+Topramezone 1% SC (Suspension Concentrate)
Ingredients Percent (w/w) Function
Pyroxasulfone a.i. 4.00 Active Ingredient
Metribuzin a.i. 16.00 Active Ingredient
Topramezone a.i. 1.00 Active Ingredient
Urea 5.00 Humectant
Copolymer butanol EO/PO 3.50 Wetting agent
Acrylic graft copolymer 1.50 Dispersing agent 1
Tri-styryl phenol with 16 moles EO 2.00 Dispersing agent 2
Attapulgite clay 2.00 Suspending agent
Polydimethyl siloxane 0.30 Antifoaming agent
1,2- benzisothiazoline-3-one 0.15 Preservative
1,2-Propylene glycol 5.00 Antifreezing agent
Xanthan gum 0.15 Thickner
Water 59.40 Diluent Water
Total 100.00

Manufacturing process for Pyroxasulfone 4%+Metribuzin 16%+Topramezone 1% SC (Suspension Concentrate)
Step 1-2% Gum Solution: Charged Xanthan gum (2.0 kg) and 1,2-benzisothiazoline-3-one (2.0 kg) into 96 kg water and homogenized. It should be made 12-18 hours prior to use.

Step 2-Charged DM water (50.70 liter), 1,2-propylene glycol (5 kg) and urea (5 kg) into designated vessel and mixed thoroughly.

Step 3-Added attapulgite clay (2 kg), copolymer butanol EO/PO (3.5 kg), acrylic graft copolymer (1.5 kg), tri-styryl phenol with 16 moles EO (2 kg) and polydimethylsiloxane (0.15 kg) into the vessel having water and homogenise the contents for 45 – 60 minutes using high shear homogeniser.

Step 4-Added pyroxasulfone technical (4 kg), metribuzin technical (16 kg) and topramezone technical (1 kg) to this premix slowly and homogenised to get uniform slurry ready for grinding.

Step 5-Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.

Step 6-Added remaining polydimethyl siloxane (0.15 kg) antifoam was added after grinding process completes and before sampling for in process analysis.

Step 7-Finally added 9.0 kg of 2% gum solution to obtain the SC formulation and sent the formulation to QC for quality check.
[00146] Storage stability results:
Laboratory storage for 14 days
Parameters Specification (in house) Initial At 54±2 0C At 0±2 0C
Pyroxasulfone content percent by mass 3.80 to 4.20 4.20 4.08 4.16
Metribuzin contnet percent by mass 15.20 to 17.60 17.50 16.50 17.20
Topramezone content percent by mass 0.950 to 1.10 1.08 1.02 1.06
Pyroxasulfone suspensibility percent mini. 80 98.55 95.65 96.25
Metribuzin suspensibility percent mini. 80 98.14 94.56 97.91
Topramezone suspensibility percent mini. 80 97.13 94.25 96.10
pH range (1% aq. Suspension) 5.0 to7.5 6.50 6.55 6.50
Pourability 95 % min 98.70 97.70 97.60
Specific gravity 1.05 – 1.15 1.09 1.09 1.09
Viscosity at spindle no.62, 20 rpm 350 -800 cps 510 520 530
Particle size (micron) D50 <3, D90 <10 2.2, 7.9 2.6, 8.5 2.7, 8.5
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage data
Parameters Specification (in house) 1 month 6 months 12 months
Pyroxasulfone content percent by mass 9.50 to 10.50 4.20 4.15 4.10
Metribuzin contnet percent by mass 3.80 to 4.40 17.50 17.20 16.60
Topramezone content percent by mass 1.90 to 2.20 1.08 1.06 1.04
Pyroxasulfone suspensibility percent mini. 80 97.85 97.61 97.19
Metribuzin suspensibility percent mini. 80 97.62 97.14 96.33
Topramezone suspensibility percent mini. 80 96.15 96.56 95.65
pH range (1% aq. Suspension) 5.0 to7.5 6.50 6.55 6.50
Pourability 95 % min 98.70 98.60 98.30
Specific gravity 1.05 – 1.15 1.09 1.09 1.09
Viscosity at spindle no.62, 20 rpm 350 -800 cps 510 510 515
Particle size (micron) D50 <3, D90 <10 2.2, 8 2.2, 8.1 2.3, 8.2
Persistent foam ml (after 1 minute) max. 60 nil nil nil

[00147] Example 3: Pyroxasulfone 4.8%+Metribuzin 20%+Sulfentrazone 20% WG (Wettable Granule)
Ingredients Percent (w/w) Function
Pyroxasulfone a.i. 4.80 Active Ingredient
Metribuzin a.i. 20.00 Active Ingredient
Sulfentrazone a.i. 20.00 Active Ingredient
Alkylated naphthalene sulfonate, sodium salt 7.00 Co-Dispersing agent
Polyacrylate polymer sodium salt 3.00 Dispersing agent
Sodium alkyl naphthalene sulfonate blend 2.00 Wetting agent
Poldimethyl siloxane 1.00 Antifoaming agent
Sodium sulfate anhydrous 5.00 Carrier cum humectant
Corn starch 5.00 Carrier
China Clay 2.09 Carrier
Total 100.00

[00148] Manufacturing process of Pyroxasulfone 4.8%+Metribuzin 20%+Sulfentrazone 20% WG (Wettable Granule)
Step 1-Charged the corn starch (5 kg), sodium sulphate anhydrous (5 kg), china clay (32.20 kg), silicone antifoam (0.5 kg), sodium alkyl napthalene sulfonate blend (2 kg), polyacrylate polymer sodium salt (3 kg), and alkylated naphthalene sulfonate sodium salt (7 kg) into a ribbon or premix blender and homogenized for 30 minutes.
Step 2-Charged pyroxasulfone technical (4.8 kg), metribuzin technical (20 kg) and sulfentrazone technical (20 kg) and homogenized for 30 minutes. The pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous (for approx. 90 minute).
Step 3-Finely grinded powder is mixed with DM water (5 liter) having polydimethyl siloxane (0.5 kg) to form extrudable dough.
Step 4-Dough is passed through extruder to get granules of required size.
Step 5-Wet granules are passed through fluidized bed drier to remove 5 kg extra water and further graded using vibrating screens.
Step 6-Final product is sent for QC approval.
Step 7-After approval material is packed in required pack sizes
[00149] Storage stability results:
Laboratory storage stability for 14 days
Parameters specification in house) Initial At 54±2 0C At 0±2 0C
Pyroxasulfone content percent by mass 4.56 to 5.28 5.20 4.96 5.12
Metribuzin contnet percent by mass 19.0 to 22.0 21.50 20.80 21.20
Sulfentrazone content percent by mass 19.0 to 22.0 21.20 20.40 20.80
Pyroxasulfone suspensibility percent min. 70 97.15 95.02 97.52
Metribuzin suspensibility percent min. 70 95.36 91.15 94.56
Sulfentrazone suspensibility percent min. 70 95.75 93.11 94.25
pH range (1% aq. Suspension) 5.5 to 7.5 7.03 7.01 7.03
wettability sec. max. 60 8 9 9
wet sieve (45 micron) percent by mass min. 98.5 99.5 99.2 99.3
bulk density (g/ml) 0.45 to 0.75 0.47 0.46 0.47
moisture content percent by mass max. max. 2% 1.1 0.8 1
Room temperature storage stability up to 12 months
Parameters Specification (in house) 1 month 6 months 12 months
Pyroxasulfone content percent by mass 4.56 to 5.28 5.20 5.10 5.02
Metribuzin contnet percent by mass 19.0 to 22.0 21.50 21.20 20.60
Sulfentrazone content percent by mass 19.0 to 22.0 21.20 20.80 20.40
Pyroxasulfone suspensibility percent min. 70 96.98 96.85 96.14
Metribuzin suspensibility percent min. 70 95.12 94.46 94.16
Sulfentrazone suspensibility percent min. 70 95.24 95.02 94.58
pH range (1% aq. Suspension) 5.5 to 7.5 7.03 7.03 7.02
wettability sec. max. 60 8 8 9
wet sieve (45 micron) percent by mass min. 98.5 99.30 99.30 99.20
bulk density (g/ml) 0.45 to 0.75 0.47 0.46 0.46
moisture content percent by mass max. max. 2% 1.10 1.00 0.90

[00150] The following formulations in the table below were manufactured according to the present invention by following the above manufacturing procedures using different excipients.
Compound C Active ingredients (%) Formulation Strength (%) Formulation Type
Compound A
Pyroxasulfone Compound B
Metribuzin Compound C
Isoxaflutole 9.6 40 10 59.60 WG
Sulcotrione 4.8 20 20 44.80 WG
Sulfentrazone 4.8 20 20 44.80 WG
Ametryn 4 16.67 40 60.67 WG
Atrazine 4 16.67 40 60.67 WG
Diuron 4 16.67 40 60.67 WG
Mesotrione 4 16 3 23.00 SC
Tembotrione 4 16 3 23.00 SC
Topramezone 4 16 1 21.00 SC
Flumioxazin 12 50 8 70.00 WG
Trifludimoxazin 12 50 8 70.00 WG
2,4-D salt 4.8 20 40 64.80 WG
Prosulfocarb 4.8 20 50 74.80 WG
Bicyclopyrone 4.8 20 30 54.80 WG
Tolpyralate 12 50 3 65.00 WG
S-metolachlor 2.5 4 20 26.50 SE
Pendimethalin 2.5 4 20 26.50 SE
Flufenacet 15 24 20 59.00 WG
Flumioxazin 15 24 18 57.00 WG

[00151] Efficacy Examples:
[00152] Bio-efficacy (Weed control %): Weed counts were recorded at 30 and 60 DAA (Days after Application by using (50 cm x 50 cm) quadrant treatment wise at 4 places randomly selected covering entire treatment. The weed control (%) calculated by using given formula.

The weed control (as observed weed control %) data was used in Colby’s formula to calculate the expected weed control (%) and synergism.
[00153] Synergism: A synergistic effect exists wherever the action of a combination of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticidal activity than the sum of the pesticidal activities of the individual components.
[00154] In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two or three active components can be calculated as follows:


[00155] Phytotoxicity: The observations on crop safety i.e. phytotoxicity or adverse effect of treatments were recorded for symptoms visible. All the visual phytotoxicity symptoms like plant yellowing, leaf scorching, bleaching, necrosis, stunting, crinkling, epinasty, hyponasty recorded on the basis of entire plot in comparison with untreated control (UTC) plot. Each individual visual symptoms were recorded on the basis severity of injury i.e. from 0 to 100%. The observations on productive tillers were recorded from 4 spots, each spots of 1m x 1m size and represented as number of productive tiller per 1 sq.m. area. Plant height (in cm) were also recorded
[00156] FIELD BIO-EFFICACY STUDIES:
[00157] The field experiments were carried out to study the bio-efficacy, phytotoxicity and synergism.
[00158] Example 1: Bio-efficacy against mixed weedflora in wheat, Triticum aestivum
Example 1: Bioefficacy against mixed weedflora in wheat, Triticum aestivum
Crops: Wheat
Location: Khanna, Punjab
No. of Treatments: As per treatment details
Plot size: 24 sq.m.
Application Time: 2 DAS (Days after sowing)
Spray Volume: 500 liter water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle boom.
Agronomic practices: All the required agronomic practices followed except herbicidal application.
Table 1: Treatment details
Treatment number Treatment details Application Rate (gai/h)
T1 Pyroxasulfone 2.5%+Metribuzin 4%+S-metolachlor 20% SE 75+120+600
T2 Pyroxasulfone 2.5%+Metribuzin 4%+Pendimethalin 20% SE 75+120+600
T3 Pyroxasulfone 15%+Metribuzin 24%+Flufenacet 20% WG 75+120+100
T4 Pyroxasulfone 15%+Metribuzin 24%+Flumioxazin 18% WG 75+120+90
T5 Pyroxasulfone 85% WDG+Metribuzin 70% WP 75+120
T6 Pyroxasulfone 85% WDG+S-metolachlor 50% EC 75+600
T7 Pyroxasulfone 85% WDG+Pendimethalin 30% EC 75+600
T8 Pyroxasulfone 85% WDG+Flufenacet 50% SC 75+100
T9 Pyroxasulfone 85% WDG+Flumioxazine 50% SC 75+90
T10 Metribuzin 70% WP+S-metolachlor 50% EC 120+600
T11 Metribuzin 70% WP+Pendimethalin 30% EC 120+600
T12 Metribuzin 70% WP+Flufenacet 50% SC 120+100
T13 Metribuzin 70% WP+Flumioxazine 50% SC 120+90
T14 Pyroxasulfone 85% WDG 75
T15 Metribuzin 70% WP 120
T16 S-metolachlor 50% EC 600
T17 Pendimethalin 30% EC 600
T18 Flufenacet 50% SC 100
T19 Flumioxazine 50% SC 90
T20 Untreated Control (UTC) 0
T1, T2, T3 and T4 are ready mix innovative combinations. T5 to T13 are conventional tank mix combinations.
SE suspo emulsion, WG Wettable Granule, WP Wettable powder, EC emulsifiable concentrate, SC Suspension concentrate. Gai/h gram active per hectare.
Table 2: Bioefficacy against mixed weedflora in wheat crop
Treatment number % Weed control Synergism (Y/N) Average number of productive tillers/sq.mt. Plant height (cm)
30 DAA 60 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 98.2 96.06 1.02 95.2 88.77 1.07 Y 304.2 90.9
T2 97.8 95.80 1.02 94.6 88.08 1.07 Y 302.8 91.2
T3 99.2 96.15 1.03 94.2 89.55 1.05 Y 303.0 91.6
T4 98.6 95.61 1.03 93.8 87.66 1.07 Y 301.2 90.8
T5 87.8 88.27 0.99 71.4 76.98 0.93 N 288.6 88.2
T6 88.6 89.52 0.99 70.8 78.72 0.90 N 290.4 88.7
T7 87.4 88.83 0.98 71.8 77.42 0.93 N 291.4 89.0
T8 88.2 89.77 0.98 73.4 80.21 0.92 N 293.4 88.5
T9 87.6 88.33 0.99 67.6 76.63 0.88 N 289.6 87.9
T10 86.8 87.37 0.99 66.2 74.23 0.89 N 291.2 86.2
T11 86 86.54 0.99 62.4 72.65 0.86 N 288.4 86.7
T12 87.2 87.67 0.99 68.2 76.03 0.90 N 285.6 86.4
T13 85.2 85.94 0.99 61.2 71.70 0.85 N 283.8 86.5
T14 68.8 56.4 275.6 85.8
T15 62.4 47.2 273.4 84.9
T16 66.4 51.2 275.4 84.7
T17 64.2 48.2 273.4 84.8
T18 67.2 54.6 276.2 85.1
T19 62.6 46.4 272.2 83.2
T20 0.0 0.0 262.4 80.7
DAA days after application; OV observed value, EV expected value.
Weed flora observed in trial plots were Grasses-Phalaris minor, broad leaf weeds-Chenopodium album, Melilotus spp., Medicago spp.
[00159] Observations: All the ready mix innovative combinations of pyroxasulfone+metribuzin+herbicide (T1 to T4) provide excellent synergistic control of all weeds (grasses and broadleaf weeds) in wheat crop and also produce higher number of productive tillers as compared to all conventional tank mix combinations (T5 to T13). None of the treatment shows any kind of phytotoxicity symptoms in wheat crop.
[00160] Example 2: Weed control and crop safety in sugarcane, Saccharum officinarum
Crops: Sugarcane
No. of Treatments: As per treatment details
Plot size: 40 sq. mt.
Application Time: 10 DAP (Days after planting)
Spray Volume: 500 liter water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices followed except herbicidal application.
Observations: weed control(%), phytotoxicity observations methods were followed same as given in example 1.
Shoot count: Count the number of shoots per 1 meter row length (mrl). Record such observations from 5 spots per plot and present the data as number of shoot per mrl.

Table 3: Treatment details
Treatment number Treatment details Application Rate (gai/h)
T1 Pyroxasulfone 9.6%+Metribuzin 40%+Isoxaflutole 10% WG 120+500+125
T2 Pyroxasulfone 4.8%+Metribuzin 20%+Sulfentrazone 20% WG 120+500+500
T3 Pyroxasulfone 4%+Metribuzin 16.67%+Atrazine 40% WG 120+500+1200
T4 Pyroxasulfone 85% WDG+Metribuzin 70% WP 120+500
T5 Pyroxasulfone 85% WDG+Isoxaflutole 75% WG 120+125
T6 Pyroxasulfone 85% WDG+Sulfentrazone 39.6% SC 120+500
T7 Pyroxasulfone 85% WDG+Atrazine 50% WP 120+1200
T8 Metribuzin 70% WP+Isoxaflutole 75% WG 500+125
T9 Metribuzin 70% WP+Sulfentrazone 39.6% SC 500+500
T10 Metribuzin 70% WP+Atrazine 50% WP 500+1200
T11 Pyroxasulfone 85% WDG 120
T12 Metribuzin 70% WP 500
T13 Isoxaflutole 75% WG 125
T14 Sulfentrazone 39.6% SC 500
T15 Atrazine 50% WP 1200
T16 Untreated Control (UTC) 0
T1, T2 and T3 are ready mix innovative combinations. T4 to T10 are conventional tank mix combinations.
Table 4: Synergistic weed control in sugarcane
Treatment number % Weed control Synergism (Y/N) Average number of shoots/mrl at 75 DAA
30 DAA 60 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 99.8 95.64 1.04 93.8 84.72 1.11 Y 77.5
T2 99.2 95.17 1.04 92.2 83.20 1.11 Y 79.4
T3 99.6 94.16 1.06 91.4 81.43 1.12 Y 78.5
T4 87.6 85.26 1.03 66.2 68.43 0.97 N 74.8
T5 90.2 88.40 1.02 71.8 73.28 0.98 N 75.3
T6 89.6 87.14 1.03 67.8 70.63 0.96 N 74.9
T7 85.8 84.48 1.02 64.6 67.54 0.96 N 75.1
T8 90.4 88.87 1.02 70.2 72.32 0.97 N 72.3
T9 89.6 87.67 1.02 66.8 69.57 0.96 N 73.1
T10 87.4 85.11 1.03 63.2 66.37 0.95 N 73.3
T11 60.8 44.8 71.7
T12 62.4 42.8 70.8
T13 70.4 51.6 72.1
T14 67.2 46.8 70.9
T15 60.4 41.2 71.7
T16 0.0 0.0 65.3
Weed flora of trial plot: Grassy weeds (Echinochloa colonum, Eleusine indica), Broad leaf weeds (Trianthema monogyna, Digera arvensis, Amaranthus viridis), Sedges (Cyperus rotundus). DAA Days after application; OV observed value, EV expected value.
[00161] Observations: All the ready mix combinations of pyroxasulfone+metribuzin+herbicide (T1 to T3) provide synergistic control of weeds with residual control and does not show any kind of phytotoxicity to the sugarcane crop. The treatment number T4 to T10 also produce higher number of shoots per mrl which are directly contributing to the cane yield.
[00162] Example 3: Crop safety and weed control in sugarcane, Saccharum officinarum
Crops: Sugarcane
No. of Treatments: As per treatment details
Plot size: 50 sq. mt.
Application Time: 4 to 6 leaf stage of weed and crop as 40 DAP (Days after planting)
Spray Volume: 500 liter water per hectare
Application Equipment: Manually operated knapsack sprayer fitted with flat fat nozzle
Agronomic practices: All the required agronomic practices followed except herbicidal application.
Observations: as given in example 2.
Table 5: Treatment details
Treatment number Treatment details Application Rate (gai/h)
T1 Pyroxasulfone 4%+Metribuzin 16%+Topramezone 1% SC 100+400+25
T2 Pyroxasulfone 4%+Metribuzin 16%+Mesotrione 3% SC 100+400+75
T3 Pyroxasulfone 4%+Metribuzin 16%+Tembotrione 3% SC 100+400+75
T4 Pyroxasulfone 85% WDG+ Metribuzin 70% WP 100+400
T5 Pyroxasulfone 85% WDG+ Topramezone 33.6% SC 100+25
T6 Pyroxasulfone 85% WDG+ Mesotrione 42% SC 100+75
T7 Pyroxasulfone 85% WDG+ Tembotrione 42% SC 100+75
T8 Metribuzin 70% WP+ Topramezone 33.6% SC 400+25
T9 Metribuzin 70% WP+ Mesotrione 42% SC 400+75
T10 Metribuzin 70% WP+ Tembotrione 42% SC 400+75
T11 Pyroxasulfone 85% WDG 100
T12 Metribuzin 70% WP 400
T13 Topramezone 33.6% SC 25
T14 Mesotrione 42% SC 75
T15 Tembotrione 42% SC 75
T16 Untreated Control (UTC) 0
T1, T2 and T3 are ready mix innovative combinations. T4 to T10 are conventional tank mix combinations. NIS (Non-ionic surfactant) has been added in all treatments @ 2.5 ml/liter of water.
Table 6: Synergistic weed control
Treatment number % Weed control Synergism (Y/N)
20 DAA 40 DAA
OV EV Colby's ratio OV EV Colby's ratio
T1 100 93.60 1.07 92.2 83.83 1.10 Y
T2 100 92.87 1.08 92.8 83.22 1.12 Y
T3 100 92.43 1.08 91.6 82.88 1.11 Y
T4 82.8 79.87 1.04 62.2 66.02 0.94 N
T5 87.4 86.26 1.01 68.6 72.77 0.94 N
T6 86.2 84.71 1.02 67.4 71.74 0.94 N
T7 84.4 83.76 1.01 68.6 71.17 0.96 N
T8 86.8 85.18 1.02 66.6 71.73 0.93 N
T9 84.6 83.50 1.01 64.6 70.66 0.91 N
T10 83.8 82.48 1.02 63.8 70.06 0.91 N
T11 56.8 42.8
T12 53.4 40.6
T13 68.2 52.4
T14 64.6 50.6
T15 62.4 49.6
T16 0.0 0.0
Weed flora of trial plot-Grassy weeds (Dactyloctenium aegyptium, Brachiaria mutica, Panicum spp.), Broad leaf weeds (Trianthema mongyna, Parthenium hysterophorus), and Sedges (Cyprus rotundus).
[00163] Observations: All the ready mix combinations of pyroxasulfone+metribuzin+herbicide (T1 to T3) provides synergistic control of weeds with residual control and does not shows any kind of phytotoxicity to the sugarcane crop.
[00164] Summary of field trials:
The ready mix formulations of pyroxasulfone+metribuzin+herbicide provide synergistic weed control.
The ready mix formulations of pyroxasulfone+metribuzin+herbicide provide desirable residual control of weeds.
The ready mix formulations of pyroxasulfone+metribuzin+herbicide provide excellent control of tough to control weeds in single shot application. Farmers do not need to apply frequently.
The ready mix formulations of pyroxasulfone+metribuzin+herbicide do not show phytotoxicity to wheat and sugarcane and do not have any kind of negative impact on crop growth.
The ready mix formulations of pyroxasulfone+herbicide+herbicide increase tillers counts, shoot counts which are directly contributing to the crop yield.
[00165] While the foregoing describes various embodiments of the disclosure, other and further embodiments of the disclosure may be devised without departing from the basic scope thereof. The invention is not limited to the described embodiments, versions or examples, which are included to enable a person having ordinary skill in the art to make and use the invention when combined with information and knowledge available to the person having ordinary skill in the art.
[00166] The foregoing embodiments are merely illustrative and are not to be taken as limitations upon the scope of the invention. Various changes and modifications to the disclosed embodiments will be apparent to those skilled in the art. Such changes and modifications may be made without departing from the scope of the invention.

ADVANTAGES OF THE INVENTION
[00167] The present disclosure provides a composition comprising combination of compounds having synergistic herbicidal effect.
[00168] The present disclosure provides a composition comprising herbicides, said composition being stable.
[00169] The present disclosure provides a composition comprising herbicide compounds for effective control of wide array of weeds.
[00170] The present disclosure provides a composition that can help delay, reduce and/or avoid the onset of herbicidal resistance or can be used on weeds already resistant to existing herbicides.
,CLAIMS:1. A synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) at least one additional herbicidal compound; and
(d) optionally agriculturally acceptable excipients.

2. The synergistic herbicide composition as claimed in claim 1, wherein the at least one additional herbicidal compound is selected from the group consisting of S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin.

3. The synergistic herbicide composition as claimed in claim 1 or 2, wherein the at least one additional herbicidal compound is selected from the group consisting of S-metolachlor, topramezone, and sulfentrazone.

4. A synergistic herbicide composition comprising combination of:
(a) effective amount of [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone;
(b) effective amount of 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one;
(c) at least one additional herbicidal compound is selected from the group consisting of S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin; and
(d) optionally agriculturally acceptable excipients.

5. The synergistic herbicide composition as claimed in any one of the claims 1 to 4, wherein the agriculturally acceptable excipient is selected from wetting agents, dispersing agents, suspending agent, anti-foaming agent, anti-freezing agent, preservatives, thickeners, solvents, emulsifiers, stabilizers, buffering agents, solid carriers, humectants, disintegrating agents, fillers, colorants, fertilizers, surfactants, tackifiers, pH regulators, and a combination thereof.

6. The synergistic herbicide composition as claimed in any one of the claims 1 to 5, wherein the [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone is present in an amount ranges from 0.01 % to 50% by weight of the composition.

7. The synergistic herbicide composition as claimed in any one of the claims 1 to 5, wherein the 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one is present in an amount ranges from 0.01 % to 50% by weight of the composition.

8. The synergistic herbicide composition as claimed in any one of the claims 1 to 5, wherein the at least one herbicidal compound is present in an amount ranges from 0.01 % to 50% by weight of the composition.

9. The synergistic herbicide composition as claimed in any one of the claims 1 to 5, wherein the agriculturally acceptable excipients is present in an amount ranges from 0 % to 80% by weight of the composition.

10. The synergistic herbicide composition as claimed in any one of the claims 1 to 5, wherein the composition comprises:
(a) 0.01 % to 50% [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone by weight of the composition;
(b) 0.01 % to 50% 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one by weight of the composition;
(c) 0.01 % to 50% at least one herbicidal compound selected from the group consisting of S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin by weight of the composition; and
(d) 0 % to 80% agriculturally acceptable excipients by weight of the composition.

11. The synergistic herbicide composition as claimed in any one of the claims 1 to 5, wherein the composition comprises:
(a) 2.5% to 20% [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 4,5-dihydro-5,5-dimethylisoxazol -3-yl sulfone by weight of the composition;
(b) 4% to 50% 4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one by weight of the composition;
(c) 1 % to 50% at least one herbicidal compound selected from the group consisting of S-metolachlor, topramezone, sulfentrazone, isoxaflutole, sulcotrione, ametryn, atrazine, diuron, mesotrione, tembotrione, flumioxazin, trifludimoxazin, 2,4-D salt, prosulfocarb, bicyclopyrone, tolpyralate, pendimethalin, flufenacet, and flumioxazin by weight of the composition by weight of the composition; and
(d) 10% to 80% agriculturally acceptable excipients by weight of the composition.

12. The synergistic herbicide composition as claimed in any one of the claims 1 to 11, wherein the composition is in the form of capsule suspension (CS), dispersible concentrate (DC), emulsifiable concentrate (EC), emulsion, water in oil (EO), emulsion, oil in water (EW), jambo balls or bags (bags in water soluble pouch), micro-emulsion (ME), oil dispersion (OD), oil miscible flowable concentrate (oil miscible suspension) (OF), oil miscible liquid (OL), suspension concentrate (SC), suspo-emulsion (SE), soluble concentrate (SL), water dispersible granule (WDG), wettable granule (WG), water soluble granule (SG), water soluble powder (SP), wettable powder (WP), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), and Controlled release granules (CR).
13. The synergistic herbicide composition as claimed in claim 12, wherein the composition is in the form of suspo-emulsion (SE), suspension concentrate (SC), and wettable granule (WG).

14. The synergistic herbicide composition as claimed in any one of the claims 1 to 13, for use in controlling weeds growing amongst crop plants.

15. A method of controlling weeds growing amongst crop plants by application of an effective amount of a composition as claimed in any one of the claims 1 to 13.