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A Cyclic Peptide
Abstract: Cyclic peptides and peptidomimetics are provided that bind to and/or modulate activities associated with Trk receptors, including processes associated with the growth and repair of the central nervous system (e.g., neuronal growth and survival, axonal growth, neurite outgrowth and synaptic plasticity). Cyclic peptides and peptidomimetics are also provided that block or reduce the effect of other factors that inhibit growth and/or repair of the central nervous system. Pharmaceutical compositions and other formulations comprising these compounds are provided. In addition, the invention provides methods for using the cyclic peptides and peptidomimetics to modulate Trk mediated activities, including processes such as neuronal growth, survival and recover, axonal growth, neurite outgrowth, and synaptic plasticity. Further, the invention provides methods for promoting central nervous system (CNS) neuron growth by administering a p75 receptor binding agent.
Notices, Deadlines & Correspondence
Patent Information
Applicants
WYETH
KING'S COLLEGE LONDON
Inventors
1. DOHERTY PATRICK
2. WILLIAMS GARETH
Specification
Cyclic peptides and peptidomimetics are provided that bind to and/or modulate activities associated with Trk receptors, including processes associated with the growth and repair of the central nervous system (e.g., neuronal growth and survival, axonal growth, neurite outgrowth and synaptic plasticity). Cyclic peptides and peptidomimetics are also provided that block or reduce the effect of other factors that inhibit growth and/or repair of the central nervous system. Pharmaceutical compositions and other formulations comprising these compounds are provided. In addition, the invention provides methods for using the cyclic peptides and peptidomimetics to modulate Trk mediated activities, including processes such as neuronal growth, survival and recover, axonal growth, neurite outgrowth, and synaptic plasticity. Further, the invention provides methods for promoting central nervous system (CNS) neuron growth by administering a p75 receptor binding agent.
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 885-KOLNP-2006-INTERNATIONAL SEARCH REPORT & OTHERS.pdf | 2016-12-30 |
| 1 | abstract-00885-kolnp-2006.jpg | 2011-10-07 |
| 2 | 885-KOLNP-2006-ABSTRACT.pdf | 2016-12-29 |
| 2 | 885-KOLNP-2006-FORM 3-1.2.pdf | 2011-10-07 |
| 3 | 885-KOLNP-2006-EXAMINATION REPORT REPLY RECIEVED.pdf | 2011-10-07 |
| 3 | 885-KOLNP-2006-AMENDED CLAIMS.pdf | 2016-12-29 |
| 4 | 885-KOLNP-2006-CORRESPONDENCE-1.2.pdf | 2011-10-07 |
| 4 | 885-KOLNP-2006-ASSIGNMENT.pdf | 2016-12-29 |
| 5 | 885-KOLNP-2006-CANCELLED PAGES.pdf | 2016-12-29 |
| 5 | 885-KOLNP-2006-AMANDED CLAIMS.pdf | 2011-10-07 |
| 6 | 885-KOLNP-2006-CLAIMS 1.pdf | 2016-12-29 |
| 6 | 00885-kolnp-2006-priority document.pdf | 2011-10-07 |
| 7 | 885-KOLNP-2006-CLAIMS.pdf | 2016-12-29 |
| 7 | 00885-kolnp-2006-pct form.pdf | 2011-10-07 |
| 8 | 885-KOLNP-2006-CORRESPONDENCE.pdf | 2016-12-29 |
| 8 | 00885-kolnp-2006-international search authority report.pdf | 2011-10-07 |
| 9 | 00885-kolnp-2006-international publication.pdf | 2011-10-07 |
| 9 | 885-KOLNP-2006-DESCRIPTION (COMPLETE).pdf | 2016-12-29 |
| 10 | 885-KOLNP-2006-DRAWINGS.pdf | 2016-12-29 |
| 11 | 00885-kolnp-2006-form-1.pdf | 2011-10-07 |
| 11 | 885-KOLNP-2006-FIRST EXAMINATION REPORT.pdf | 2016-12-29 |
| 12 | 00885-kolnp-2006-form 5.pdf | 2011-10-07 |
| 12 | 885-KOLNP-2006-FORM 1.pdf | 2016-12-29 |
| 13 | 00885-kolnp-2006-form 3.pdf | 2011-10-07 |
| 13 | 885-KOLNP-2006-FORM 13.pdf | 2016-12-29 |
| 14 | 00885-kolnp-2006-form 13.pdf | 2011-10-07 |
| 14 | 885-KOLNP-2006-FORM 18.pdf | 2016-12-29 |
| 15 | 00885-kolnp-2006-drawings.pdf | 2011-10-07 |
| 15 | 885-KOLNP-2006-FORM 2.pdf | 2016-12-29 |
| 16 | 00885-kolnp-2006-description(complete).pdf | 2011-10-07 |
| 16 | 885-KOLNP-2006-FORM 3.pdf | 2016-12-29 |
| 17 | 885-KOLNP-2006-FORM 5.pdf | 2016-12-29 |
| 17 | 00885-kolnp-2006-correspondence others.pdf | 2011-10-07 |
| 18 | 885-KOLNP-2006-GPA.pdf | 2016-12-29 |
| 19 | 00885-kolnp-2006-claims.pdf | 2011-10-07 |
| 19 | 885-KOLNP-2006-INTERNATIONAL PUBLICATION.pdf | 2016-12-29 |
| 20 | 885-KOLNP-2006-OTHERS.pdf | 2016-12-29 |
| 21 | 00885-kolnp-2006-asignment.pdf | 2011-10-07 |
| 21 | 885-KOLNP-2006-PETITION UNDER RULE 137.pdf | 2016-12-29 |
| 22 | 00885-kolnp-2006-amended page.pdf | 2011-10-07 |
| 22 | 885-KOLNP-2006-REPLY TO EXAMINATION REPORT.pdf | 2016-12-29 |
| 23 | 00885-kolnp-2006-abstract.pdf | 2011-10-07 |
| 23 | 885-KOLNP-2006-SEQUENCE LISTING.pdf | 2016-12-29 |
| 24 | 00885-kolnp-2006 form-18.pdf | 2011-10-07 |
| 24 | 885-KOLNP-2006-SPECIFICATION-COMPLETE.pdf | 2016-12-29 |
| 25 | 885-KOLNP-2006-(23-12-2016)-HEARING NOTICE.pdf | 2016-12-23 |
| 25 | 00885-kolnp-2006 correspondence.pdf | 2011-10-07 |
| 26 | 885-KOLNP-2006_EXAMREPORT.pdf | 2016-06-30 |
| 26 | 885-KOLNP-2006-(31-05-2012)-CORRESPONDENCE.pdf | 2012-05-31 |
| 27 | 885-KOLNP-2006-(31-05-2012)-CORRESPONDENCE.pdf | 2012-05-31 |
| 27 | 885-KOLNP-2006_EXAMREPORT.pdf | 2016-06-30 |
| 28 | 00885-kolnp-2006 correspondence.pdf | 2011-10-07 |
| 28 | 885-KOLNP-2006-(23-12-2016)-HEARING NOTICE.pdf | 2016-12-23 |
| 29 | 00885-kolnp-2006 form-18.pdf | 2011-10-07 |
| 29 | 885-KOLNP-2006-SPECIFICATION-COMPLETE.pdf | 2016-12-29 |
| 30 | 00885-kolnp-2006-abstract.pdf | 2011-10-07 |
| 30 | 885-KOLNP-2006-SEQUENCE LISTING.pdf | 2016-12-29 |
| 31 | 00885-kolnp-2006-amended page.pdf | 2011-10-07 |
| 31 | 885-KOLNP-2006-REPLY TO EXAMINATION REPORT.pdf | 2016-12-29 |
| 32 | 00885-kolnp-2006-asignment.pdf | 2011-10-07 |
| 32 | 885-KOLNP-2006-PETITION UNDER RULE 137.pdf | 2016-12-29 |
| 33 | 885-KOLNP-2006-OTHERS.pdf | 2016-12-29 |
| 34 | 00885-kolnp-2006-claims.pdf | 2011-10-07 |
| 34 | 885-KOLNP-2006-INTERNATIONAL PUBLICATION.pdf | 2016-12-29 |
| 35 | 885-KOLNP-2006-GPA.pdf | 2016-12-29 |
| 36 | 00885-kolnp-2006-correspondence others.pdf | 2011-10-07 |
| 36 | 885-KOLNP-2006-FORM 5.pdf | 2016-12-29 |
| 37 | 00885-kolnp-2006-description(complete).pdf | 2011-10-07 |
| 37 | 885-KOLNP-2006-FORM 3.pdf | 2016-12-29 |
| 38 | 885-KOLNP-2006-FORM 2.pdf | 2016-12-29 |
| 38 | 00885-kolnp-2006-drawings.pdf | 2011-10-07 |
| 39 | 00885-kolnp-2006-form 13.pdf | 2011-10-07 |
| 39 | 885-KOLNP-2006-FORM 18.pdf | 2016-12-29 |
| 40 | 00885-kolnp-2006-form 3.pdf | 2011-10-07 |
| 40 | 885-KOLNP-2006-FORM 13.pdf | 2016-12-29 |
| 41 | 00885-kolnp-2006-form 5.pdf | 2011-10-07 |
| 41 | 885-KOLNP-2006-FORM 1.pdf | 2016-12-29 |
| 42 | 00885-kolnp-2006-form-1.pdf | 2011-10-07 |
| 42 | 885-KOLNP-2006-FIRST EXAMINATION REPORT.pdf | 2016-12-29 |
| 43 | 885-KOLNP-2006-DRAWINGS.pdf | 2016-12-29 |
| 44 | 00885-kolnp-2006-international publication.pdf | 2011-10-07 |
| 44 | 885-KOLNP-2006-DESCRIPTION (COMPLETE).pdf | 2016-12-29 |
| 45 | 00885-kolnp-2006-international search authority report.pdf | 2011-10-07 |
| 45 | 885-KOLNP-2006-CORRESPONDENCE.pdf | 2016-12-29 |
| 46 | 00885-kolnp-2006-pct form.pdf | 2011-10-07 |
| 46 | 885-KOLNP-2006-CLAIMS.pdf | 2016-12-29 |
| 47 | 00885-kolnp-2006-priority document.pdf | 2011-10-07 |
| 47 | 885-KOLNP-2006-CLAIMS 1.pdf | 2016-12-29 |
| 48 | 885-KOLNP-2006-CANCELLED PAGES.pdf | 2016-12-29 |
| 48 | 885-KOLNP-2006-AMANDED CLAIMS.pdf | 2011-10-07 |
| 49 | 885-KOLNP-2006-ASSIGNMENT.pdf | 2016-12-29 |
| 49 | 885-KOLNP-2006-CORRESPONDENCE-1.2.pdf | 2011-10-07 |
| 50 | 885-KOLNP-2006-EXAMINATION REPORT REPLY RECIEVED.pdf | 2011-10-07 |
| 50 | 885-KOLNP-2006-AMENDED CLAIMS.pdf | 2016-12-29 |
| 51 | 885-KOLNP-2006-FORM 3-1.2.pdf | 2011-10-07 |
| 51 | 885-KOLNP-2006-ABSTRACT.pdf | 2016-12-29 |
| 52 | abstract-00885-kolnp-2006.jpg | 2011-10-07 |
| 52 | 885-KOLNP-2006-INTERNATIONAL SEARCH REPORT & OTHERS.pdf | 2016-12-30 |