CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS RELATED APPLICATIONS [0001] This application claims benefit under one or more of 35 U.S.C. § 119(a)-l 19(d) of Indian Patent Application No. IN 1770/DEL/201, filed June 22, 201 land under 35 U.S.C. § 119(e) of the U.S. Provisional Application No. 61/514,305, filed August 2, 2011, the content of both applications are incorporated herein by reference in their entirety. FIELD OF THE INVENTION [0002] The invention relates to the field of personal care products. More specifically, the invention relates to conjugate-based antifungal and antibacterial prodrugs formed by coupling an antifungal agent or an antibacterial agent with linker(s) or carrier(s) and nanoparticles comprising the conjugate based prodrugs. The invention also relates to conjugated prodrugs in the form of nanoaprticels. The invention also relates tonon-cojugated antifungal and antibacterial agents in the form of nanoparticles along one or more lipids. BACKGROUND OF THE INVENTION [0003] Dandruff is a chronic scalp condition that causes scaling and flaking of the skin. The causes of dandruff are not entirely known. Currently, fungi of the genus Malassezia, are believed to be the likely responsible agents (Dawson, Thomas L. J. Investig. Dermatol. Symp, Proc. (2007), 12:1519). These fungi are highly dependent on external lipids for in vitro growth (Chen TA, Hill PV 2005, Vet Dermatol 16:4). The lipid dependence of Malassezia can be explained by the apparent absence of fatty acid synthase gene (Jun Xu, et al PNAS, 2007, 104:18730). Further, the inability to synthesize fatty acids may be complimented by the presence of multiple secreted lipases to aid in harvesting host lipids. Consequently, these fungi metabolize triglycerides present in sebum through these lipases resulting in lipid byproducts. Penetration of the top layer of the epidermis, the stratum corneum, by some of these lipid byproducts results in an inflammatory response in susceptible persons, which disturbs homeostasis causing erratic cleavage of stratum corneum cells. The primary treatment for dandruff is the topical application of antifungal agents that reduce the level of Malassezia on the scalp. Typically, the antifungal agent is applied to the scalp as a component of a shampoo or other hair care composition. However, the antidandruff agents are in contact with the scalp for a short period of time, necessitating long, repeated use of the hair care composition. A long-lasting, durable dandruff treatment would represent an advance in the art. [0004] In view of the above, a need exists for antidandruff agents that provide improved durability for long lasting effects and are easy and inexpensive to prepare. SUMMARY OF THE INVENTION [0005] Described herein are novel conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one antifungal agent or antibacterial agent with at least one linker and/or carrier. In some embodiments the conjugate-based prodrug has the general structure: (AFA)m-X-(L)n, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 2 to 10; and n ranges from 2 to 10. [0006] Typically, m is 2, 3, 4, or 5. And, n is 2, 3, 4, or 5. [0007] In some embodiments, the conjugate-based prodrug has the general formula: (Formula Removed) wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m' is 1 to 10; and p is 1 to 10. [0008] Typically, m is 1, 2, 3, 4, or 5. And, p is 1, 2, 3, 4, or 5. In some embodiments, m' and p are both 1. [0009] In some embodiments, the conjugate-based prodrug has the general formula: (Formula Removed) wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; n' is 1 to 10; and q is 1 to 10, provided that that q' and n are not both 1. [0010] Typically, n' is 1, 2, 3, 4, or 5. Generally q is 1, 2, 3, 4, or 5. In some embodiments, q is 1 and n' is 2. [0011] In some embodiments, the conjugate-based antifungal prodrug has the general formula: (Formula Removed) wherein: AFA is an antifungal agent or an antibacterial agent; X is a linker; and m"is 1 to 10. [0012] Typically, m" is 1,2, 3, 4, or 5. In some embodiments, m" is 2. [0013] When a conjugate comprises two or more antifungal and/or antibacterial agents, such agents can be the same or different. Similarly, when a conjugate comprises two or more carrier, such agents can be the same or different [0014] Described herein also are personal care compositions comprising an effective amount of a conjugate-based antifungal or antibacterial prodrug described herein. [0015] In another aspect, the invention provides a method for treating or preventing dandruff comprising applying a personal care composition described herein to the scalp of a subject in need thereof. [0016] In yet another aspect, the invention provides a method for treating or preventing acne comprising applying a personal care compositions described herein to the skin of a subject in need thereof. BRIEF DESCRIPTION OF THE DRAWINGS [0017] Figures 1A-21 show exemplary conjugated prodrugs, carriers and linkers. In Figures 13 and 14, RC2OH can be selected from, but is not limited to, a carboxylic acid selected from a saturated or unsaturated fatty acid, comprising a C8 to C26 carbon chain; a polymer with terminal -CO2H functionality (e.g., PLGA, PLA, HO2C-PEG-CO2H, and the like); an antibacterial agent having a CO2H functionality, an alpha-hydroxy acid; a beta-hydroxy acid; azelaic acid; adapalene; a glycolic acid or derivative thereof of formula, (Formula Removed) wherein R' can be an antibacterial agent with CO2H functionality or a carboxylic acid that can be used to modulate the 'Hydrophilic-Lypophilic- Balance' of the conjugate (e.g., PLGA); salicyclic acid or derivative thereof of formula (Formula Removed) wherein R' can be an antibacterial agent with -CO2H functionality or a carboxylic acid that can be used to modulate the 'Hydrophilic-Lypophilic-Balance' of the conjugate (e.g., PLGA); an amino acid or peptide, 10-undecenopic acid, succinic acid or derivative therof of formula (Formula Removed) wherein R" is an antibacterial agent with -OH functionality or an alcohol that can be used to modulate the 'Hydrophilic-Lypophilic-Balance' of the conjugate (e.g., HO-PEG-OH). In Figures 17 and 20. R(CO2H)2 can be any dicarobxylic acid, for example, R(CO2H)2 can be selected from azelaic acid, oxadiacids of formula (Formula Removed) wherein n is 1 to 500, a PEG-disuccinate of formula , wherein n is 1 to 500; a diacid of formula (Formula Removed) wherein m is 1 to 28; aspartic acid, glutamic acid, a polymer with -CO2H functionality on both termini (e.g., HO2C-PEG-CO2H); or a natural or synthetic linker with -CO2H functionality on both termini. [0018] Figure 22 is a schematic of the conjugated prodrugs of the invention. [0019] Figures 23 and 24 show size distribution of nanoparticles comprising clindamycin undecylene (Figure 23) and clindamycin laurate (Figure 24) described herein. [0020] Figurs 25-27 are photogrpahs of MIC Agar plate assay for the TEG based conjugates (Figure 25), methylene and ethylene based conjugates (Figure 26), KMP and KAH conjugates (Figure 27). Concentrations of drugs used were 0.0625 ug/ml to 16 µg/ml (Figure 25), 0.0625 µg/ml to 8 ug/ml along with growth controls, normal saline and 1% DMSO (Figure 26), and 0.125 µg/ml and 4 ug/ml (Figure 27 [0021] Figure 28 is photograph of a representative Zone of Inhibition as determined by agar well diffusion method. [0022] Figure 29 is a line graph showing biological efficacy comparison between control ketoconazole, ketoconazole methylene palmitate (KMP), and negative control Keto-N-hexadecylacetamide (KAH) by Zone of inhibition. The prodrug conjugates comprised ester linkages while the negative control KAH comprised an amide linkage. [0023] Figure 30 is a line graph showing the Time kill assay of M. furfur with ketoconazole and ketoconazole-methylene-caprylate (KMC) at 0.25 µg/ml concentration. [0024] Figure 31A is a line graph showing the Time kill assay of M furfur with different concentrations of prodrug KMC. Concentation of the prodrug KMC ranged from 0.125 µg/ml to 1.0 µg/ml. [0025] Figure 31B is a line graph showing the Time kill assay of M furfur with different concentrations of unconjugated ketoconazole. Concentation of the ketoconazole ranged from 0.125µg/mlto 1.0 µg/ml. [0026] Figurea 32A-32C are a schematic representation of intra-follicular retention of NPs and enhanced uptake of drug by fungi or bacteria. Figure 32 A is schematic representation of cross-section of a hair follicle showing presence of microbes onto stratum corneum. It also shows NPs retained into the intra-follicular space towards epidermis, which ooze out slowly and continuously with sweat and sebum. Figure 32B is a schematic representation showing interaction of intact NPs, released drug and released lipidic part with microbes. Presence of lipidic part (which acts a food for the lipophilic microbes) enhances uptake of the intact nanoparticles and / or released drug, eventually leading to cell death. Figure 32C is a schematic representation of an embodiment of a nanoparticlc described herein. DETAILED DESCRIPTION OF THE INVENTION [0027] Described herein are novel conjugate-based antifungal and/or antibacterial prodrugs formed by coupling at least one antifungal agent or antibacterial agent with at least one carrier, either directly or through a linker. Also described herein in nanoparticles comprising a non-conjugated antifungal or antibacterial agent and a lipid. [0028] The compositions described herein (e.g., conjugate-based antifungal or antibacterial compositions, nanoparticles comprising same, and nanoparticles comprising a non-conjugated antifungal or antibacterial agent and a lipid), can be used for treatment of fungal or bacterial infections. The compositions described herein can be applied locally (e.g., topically) or admiminstered systemically. [0029] The compositions described herein can be used in personal care compositions, such as hair care compositions and skin care compositions. These personal care compositions can be used to treat or prevent dandruff. Compositions described herein can also be used in skin care compositions to treat or prevent acne. In some embodiments, the composition described herein can be used to treat a fugal or bacterial infection. For example, the composition described herein can be used to treat oral/vaginal candidiasis, ring worm, (tinea infections of the body, scalp, beard, jock itch, and athlete's foot), nail infections, ear infections, and the like. [0030] In some embodiments the conjugate-based prodrug has the general structure: (Formula Removed) wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; and X is a linker. [0031] In some embodiments, the conjugate-based antifungal or antibacterial prodrug has the general formula: (Formula Removed) wherein: AFA is an antifungal agent or an antibacterial agent; and X is a linker. [0032] Without wishing to be bound by a theory, the conjugated prodrugs of the invention provide a number of advantages compared to an unconjugated antifungal and/or antibacterial agent. For example, formulation of the conjugated prodrugs into nanoparticle, allows better entrapment in skin or scalp microcracks. This in turn can allow enhanced retention time on the skin and/or scalp; allowing lower amounts of the active agent and improving bioavailability. The linker and/or the carrier can provide a synergistic effect. Additionally, the linker and/or the carrier can provide penetration enhancement. The conjugated prodrugs can also provide sustained release of the antifungal or antibacterial agent, thus providing better pharmacokinetics. Nanoparticles [0033] The conjugate-based prodrugs and unconjugated antifungal or antibacterial agents can be formulated into particles, e.g. nano- or microparticles. Formulation of the conjugate-based prodrugs or the unconjugated drugs into particles can be advantageous. For example, particles can be better trapped into microcracks of skin or scalp, thus providing a durable, long lasting effect. Accordingly, it can be possible to use lower concentrations of the antifungal or antibacterial agents compared to conventional antifungal and antibacterial agents. [0034] As used herein, the term "nanoparticle" refers to particles that are on the order of 10-9 or one billionth of a meter and below 10-6 or 1 millionth of a meter in size. The term "nanoparticle" includes nanospheres; nanorods; nanoshells; and nanoprisms; and these nanoparticles may be part of a nanonetwork. The term "nanoparticles" also encompasses liposomes and lipid particles having the size of a nanoparticle. The particles may be, e.g., monodisperse or polydisperse and the variation in diameter of the particles of a given dispersion may vary, e.g., particle diameters of between about 0.1 to 100's of nm. [0035] Without limitation, there are at least seven types of nanoparticles that can be formulated: (1) nanoparticles formed from a polymer or other material to which a conjugate-based prodrug absorbs/adsorbs or forms a coating on a nanoparticle core; (2)) nanoparticles formed from a core formed by the conjugate-based prodrug, which is coated with a polymer or other material; (3) nanoparticles formed from a polymer or other material to which a conjugate-based prodrug is covalently linked; (4) nanoparticles formed from conjugate-based prodrug and other molecules; (5) nanoparticles formed so as to comprise a generally homogeneous mixture of a conjugate-based prodrug with a constituent of the nanoparticle or other non-drug substance; (6) nanoparticles of pure drug or drug mixtures with a coating over a core of a conjugate-based prodrug; and (7) nanoparticles composed entirely of a conjugate-based prodrug. While the above is discussed with reference to conjugated prodrugs, similar types nanoparticles with unconjugated anti-bacterial or anti-fungal agents can also be prepared. [0036] In some embodiments, the nanoparticle is of size about lnm to about 1000nm, about 50nm to about 500nm, about 100nm to about 250nm, or about 200nm to about 350nm. In one embodiment, the nanoparticle is of about 100nm to about 1000nm. In another embodiment, the nanoparticle is of size about 80nm to about 200nm. In one embodiment, nanoparticle is of size about 50nm to about 500nm. In some embodiments, nanpartilce is of size about 158nm, about 218nm, or about 305nm. In some embodiments, nanoparticle is of size about 337 nm, about 526 nm, about 569 nm, about 362 nm, about 476 nm, about 480 nm, about 676 nm, about 445 nm, about 434 nm, about 462 nm, about 492 nm, about 788 nm, about 463 nm, or about 65 nm [0037] Nanoparticles described herein usually have a narrow size distribution as measuered by Polydispersity Index (PdI). As used herein, the term "polydispersity index" is a measure of the distribution broadness of a sample, and is typically defined as the relative variance in the correlation decay rate distribution, as is known by one skilled in the art. See B J. Fisken, "Revisiting the method of cumulants for the analysis of dynamic light-scattering data," Applied Optics, 40(24), 4087-4091 (2001) for a discussion of cumulant diameter and polydispersity. Generally, the polydispersity of the nanoparticles described herein is less than about 0.8. In some embodiments, the polydispersity of the nanoparticles is less than about 0.5, less than about 0.4, less than about 0.3, less than about 0.25, less than about 0.2, less than about 0.15, less than about 0.1, or less than about 0.05. In some embodiments, the polydispersity of the nanoparticles is about 0.072, about 0.1, about 0.149, or about 0.236, about 0.165, about 0.221, about 0.177, about 0.213, about 0.264, about 0.241, about 0.251, about 0.273, about 0.211, about 0.181, about 0.249, about 0.298, about 0.348, or about 0.282. [0038] Without limitations, the nanoparticle can comprise other components in addition to the prodrug conjugate described herein or the unconjugated drug. For example, the nanoparticle can comprise one or more of polymers, anionic polymers, cationic polymers, amphiphilic polymers, surfactants, lipids, phospholipids, cationic lipids, amphiphilic lipids, excipients and the like. If present in nanoparticle, each of the additional component can be present in an amount ranging from about 0.01% to about 90%, e.g., from about 0.01% to about 80%, from about 0.01% to about 70%, from about 0.01% to about 60%, from about 0.01% to about 50%, from about 0.01% to about 40%. from about 0.01% to about 30%, from about 0.01% to about 25%, of the total weight of the nanoparticle. It is to be understood that amount of a component is independent from the amount of a second component in the liposome or the emulsion. [0039] In some embodiments, the additional component is stearic acid-PEG-stearic acid or lecithin. [0040] A surfactant that can be added to the nanoparticle can be any of anionic, cationic. ampholytic and nonionic surfactants. Examples anionic surfactants include fatty esters such as sodium stearate, potassium oleate and semicurable tallow fatty acid sodium; alkyl sulfates such as sodium dodecyl sulfate, tri(2-hydroxyethyl) ammonium dodecyl sulfate and sodium octadecyl sulfate; benzensulfonates such as sodium nonyl benzanesulfonate, sodium dodecyl benzenesulfonate, sodium otadecyl benzenesulfonate and sodium dodecyl diphenylether disulfonate; naphthalenesulfonates such as sodium dodecyl naphthalenesulfonate and naphthalenesulfonic acid formalin condensates; sulfosuccinates such as sodium didodecyl sulfosuccinate and sodium dioctadodecyl sulfosuccinatc; polyoxyethylene sulfates such as sodium polyoxyethylenedodecylether sulfate, tri(2-hydroxyethyl) ammonia polyoxyethylene dodecylether sulfate, sodium polyoxyethylene octadecyl ether sulfate and sodium polyoxyethylene dodecylphenylether sulfate; and phosphates such as potassium dodecyl phosphate and sodium octadecyl phosphate. Examples of cationic surfactants include alkyl amine salts such as octadecyl ammonium acetate and coconut oil amine acetate; and fourth ammonia salts such as dodecyl trimethyl ammonium chloride, octadecyl trimethyl ammonium chloride, dioctadecyl dimethyl ammonium chloride and dodecyl benzyl dimethyl ammonium chloride. Examples of ampholytic surfactants include alkyl betains such as dodecyl betain and octadodecyl betain; and amine oxides such as dodecyl dimethyl amine oxide. Examples of nonionic surfactants include polyoxyethylene alkyl ethers such as polyoxyethylene dodecyl ether, polyoxyethylene hexadecyl ether, polyoxyethylene octadecyl ether and polyoxyethylene (9-octadecenyl) ether; polyoxyethylene phenyl ethers such as polyoxyethylene octylphenyl ether and polyoxyethylene nonylphenyl ether; oxirane polymers such as polyethylene oxide and copolymer of ethylene oxide and propylene oxide; sorbitan fatty esters such as sorbitan dodecanoic ester, sorbitan hexadecanoic ester, sorbitan octadecanoic ester, sorbitan (9-octadecenoic) ester, sorbitan (9-octadecenoic) triester, polyoxyethylene sorbitan dodekanoic ester, polyoxyethylene sorbitan hexadecanoic ester, polyoxyethylene sorbitan octadecanoic ester, polyoxyethylene sorbitan octanoic triester, polyoxyethylene sorbitan (9-octadecenoic) ester and polyoxyethylene sorbitan (9-octadecenoic) triester; sorbitol fatty esters such as polyoxyethylene sorbitol (9-octadecenoic) tetraester; glycerin fatty esters such as glycerin octadecanoic ester and glycerin (9-octadecenoic) ester; polyalkylene oxide block copolymers such poloxomers (commercially available under the trademark PLURONIC® (BASF)). [0041] Suitable commercially available amphoteric surfactants include, but are not limited to, MIRANOL® HMA sodium lauroampho acetate (38% solids) and MIRANOL® ULTRA L32 sodium lauroampho acetate available from Rhodia Novecare (Cranbury, N.J.). Suitable commercially available linear alcohol ethoxylates include, but are not limited to, SURFON1C® L12-6 six-mole ethoxylate of linear, primary 10-12 carbon number alcohol available from Huntsman Performance Products (The Woodlands, Tex.). Suitable commercially available alkyl sulfates include, but are not limited to, POLYSTEP® B-29 sodium octyl sulfate available from Stepan Company (Northfield. 111.). Suitable commercially available nonionic surfactants include, but are not limited to, oxo-alcohol polyglycol ethers such as GENAPOL® UD 070 CI 1-oxo-alcohol polyglycol ether (7 LEO) available from Clariant Corporation (Cranbury, N.J.). Suitable commercially available linear alkylbenzene sulfonic acids and their salts include, but are not limited to, NAXSOFT® 98S dodecyl Benzene Sulfonic Acid and NAXSOFT® 40S Sodium dodecyl Benzene sulfonate available from Nease Corporate (Cincinnati, Ohio). [0042] In some embodiments, surfactant is PEG-35 hydrogenated castor oil, Poloxamer 188, or sodium laureth sulphate. [0043] Some examples of materials which can serve as excipients include: (1) sugars, such as mannitol, lactose, maltose, glucose and sucrose; (2) starches, such as corn starch and potato starch; (3) cellulose, and its derivatives, such as sodium carboxymethyl cellulose, methylcellulose, ethyl cellulose, microcrystalline cellulose and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) lubricating agents, such as magnesium stearate, sodium lauryl sulfate and talc; (8) excipients, such as cocoa butter and suppository waxes; (9) oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; (10) glycols, such as propylene glycol; (11) polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol (PEG); (12) esters, such as ethyl oleate and ethyl laurate; (13) agar; (14) buffering agents, such as magnesium hydroxide and aluminum hydroxide; (15) alginic acid; (16) pyrogen-free water; (17) isotonic saline; (18) Ringer's solution; (19) ethyl alcohol; (20) pH buffered solutions; (21) polyesters, polycarbonates and/or polyanhydrides; (22) bulking agents, such as polypeptides and amino acids (23) serum component, such as serum albumin, HDL and LDL; (22) C2-C12 alchols, such as ethanol; and (23) other non-toxic compatible substances employed in pharmaceutical formulations. [0044] In some embodiments, excipient is mannitol. [0045] Without limitations, the conjugate can be formulated in any type of nanparticle, including, but not limited to, liposomes, emulsions, microemulsions, nanoemulsions, self-microemulsifying drug delivery systems (SMEDDS), polymeric nanoparticles, solid-lipid nanoparticles, nano-structured liquid crystals, and the like. [0046] In some embodiments, the conjugated prodrug or the unconjugated drug can be formulated in liposomes. As used herein, the term "liposome" encompasses any compartment enclosed by a lipid layer, which can be a monolayer or a bilayer. Liposomes may be characterized by membrane type and by size. Liposomes are also referred to as lipid vesicles in the art. In order to form a liposome the lipid molecules comprise elongated non-polar (hydrophobic) portions and polar (hydrophilic) portions. The hydrophobic and hydrophilic portions of the molecule are preferably positioned at two ends of an elongated molecular structure. When such lipids are dispersed in water they spontaneously form bilayer membranes referred to as lamellae or self arranged vesicles. The lamellae are composed of two mono layer sheets of lipid molecules with their non-polar (hydrophobic) surfaces facing each other and their polar (hydrophilic) surfaces facing the aqueous medium. The membranes formed by the lipids enclose a portion of the aqueous phase in a manner similar to that of a cell membrane enclosing the contents of a cell. Thus, the bilayer of a liposome has similarities to a cell membrane without the protein components present in a cell membrane. [0047] The liposomes that are used in the present invention are preferably formed from lipids which when combined form relatively stable vesicles. An enormous variety of lipids are known in the art which can be used to generate such liposomes. Preferred lipids include, but are not limited to, neutral and negatively charged phospholipids or sphingolipids and sterols, such as cholesterol. The selection of lipids is generally guided by consideration of, e.g., liposome size and stability in the personal care composition. [0048] Liposomes include unilamellar vesicles which are comprised of a single lipid layer and generally have a diameter of 20 to 100 nanometers; large unilamellar vesicles (LUVS) are typically larger than 100nm, which can also be produced by subjecting multilamellar liposomes to ultrasound. In some embodiments, liposomes have a diameter in the range of 20nm to 400nm. [0049] Liposomes can further comprise one or more additional lipids and/or other components such as sterols, e.g., cholesterol. Additional lipids can be included in the liposome compositions for a variety of purposes, such as to prevent lipid oxidation, to stabilize the bilayer, to reduce aggregation during formation or to attach carriers onto the liposome surface. Any of a number of additional lipids and/or other components can be present, including amphipathic, neutral, cationic, anionic lipids, and programmable fusion lipids. Such lipids and/or components can be used alone or in combination. [0050] Liposome compositions can be prepared by a variety of methods that are known in the art. See e.g., U.S. Pat. Nos. 4,235,871; 4,737,323; 4,897,355 and 5,171,678; published International Applications WO1996/14057 and W01996/37194; Feigner, P. L. et al, Proc. Natl. Acad. Sci., USA (1987) 8:7413-7417, Bangham, et al. M. Mol. Biol. (1965) 23:238, Olson, et al. Biochim. Biophys. Acta (1979) 557:9, Szoka, et al. Proc. Natl. Acad. Sci. (1978) 75: 4194, Mayhew, et al. Biochim. Biophys. Acta (1984) 775:169, Kim, et al. Biochim. Biophys. Acta (1983) 728:339, and Fukunaga, et al. Endocrinol. (1984) 115:757, content of all of which is incorporated herein by reference. [0051] In some embodiments, the conjugated prodrug or the unconjugated drug can be formulated in an emulsion. As used herein, "emulsion" is a heterogenous system of one liquid dispersed in another in the form of droplets. Emulsions are often biphasic systems comprising two immiscible liquid phases intimately mixed and dispersed with each other. Either of the phases of the emulsion can be a semisolid or a solid, as is the case of emulsion-style ointment bases and creams. The conjugate can be present as a solution in the aqueous phase, oily phase or itself as a separate phase. [0052] In some embodiments, the compositions are formulated as nanoemulsions. The term "nanoemulsion" means an emulsion wherein the particles are of sized in the nanometer scale. Nanoemuslions also include thermodynamically stable, isotropically clear dispersions of two immiscible liquids that are stabilized by interfacial films of surface-active molecules. The application of emulsion formulations via dermatological, oral and parenteral routes and methods for their manufacture have been reviewed in the literature, for example see Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y.. volume 1. p. 199; Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; and Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N. Y., volume 1, p. 335, content of all of which is herein incorporated by reference in its entirety. [0053] In some embodioments, the conjugated prodrug or the unconjugated drug can be formulated in a polymeric nanoparticle. As used herein, the term "polymeric nanoparticle" refers to a carrier system in which the prodrug conjugate is retained, encapsulated or adsorbed. The term polymeric nanoparticles can be used to denote nanospheres and nanocapsules. Nanospheres are constituted of a polymer matrix in which the prodrug conjugate is retained, encapsulated or adsorbed. Nanocapsules are constituted of a polymer container enclosing a nucleus, in which the prodrug conjugate can be dissolved, retained, or dispersed in the nucleus and/or adsorbed in the polymeric wall. [0054] Overall, the production processes for polymer nanoparticles can be classified among the methods of in situ polymerisation or methods using pre-formed polymers. Polymers commonly used in the preparation of nanoparticles are, for example poly (lactide), poly (lactideglycolide), poly (glycolide), poly (caprolactone), poly (amides), poly (anhydrides), poly (amino acids), poly (esters), poly (cyanoacrylates), poly (phosphazines), poly (phosphoesters), poly (esteramides), poly (dioxanones), poly (acetals), poly (cetals), poly (carbonates), poly (orthocarbonates), degradable poly (urethanes), chitins, chitosans, poly (hydroxybutyrates), poly (hydroxyvalerates), poly (maleic acid), poly (alkylene oxalates), poly (alkylene succinates), poly (hydroxybutyrates-co-hydroxyvalerates), and copolymers, terpolymers, oxidised cellulose, or combinations or mixtures of these materials. Some polymers that prove to be especially interesting are poly (e-caprolactone) (PCL; for example, poly (E-caprolactone) 65 Kd—Sigma Aldrich); methacryllate acid copolymers and methacryllate or acrylic esters (e.g. EUDRAGITS®); poly (alkyl methacrylate); poly (methyl methacryllate) (e.g. PMM). [0055] Polymeric nanoparticles can be produced, for example, by the methods (i) of in situ polymerisation of monomers (latex) or dispersion of pre-formed polymers (pseudolatex or artificial latex) as described in De Jaeghere F et al. Nanoparticles. In: Mathiowitz E, ed. The Encyclopedia of Controlled Drug Delivery. New York, N.Y.: Wiley and Sons Inc; 1999: 641-664 and Couvreur P, et al. Controlled drug delivery with nanoparticles: Eur JPharm Biopharm. 1995; 41: 2-13; (ii) method of emulsion-evaporation for pharmaceutical use first proposed by Gurny R, Peppas N A, Harrington D D, Banker G S. Development of biodegradable and injectable lattices for controlled release of potent drugs. Drug Dev Ind Pharm. 1981; 7: 1 -25 based on patent U.S. Pat. No. 4,177,177, with the polymer being dissolved in a volatile organic solvent immiscible in water. The organic solution is dispersed in an aqueous phase containing emulsifier and oil/ water emulsion forming facilitators; and (iii) method of the interface deposit of pre-formed polymers (nanoprecipitation) as described by l-'cssi et al. in patent U.S. Pat. No. 5,049,322. Content of all references cites in this paragraph is incorporated herein by reference. [0056] The organic solvents that can be used for the preparation of nanoparticles are: small chain alcohols (methanol, ethanol, isopropanol, etc.), small chain ketones (acetone, methyl-ethyl-ketone. etc.), light hydrocarbons or a mixture of light hydrocarbons (hexane, petroleum ether, etc.), lightly chlorated hydrocarbons (chloroform, methylene hydrochloride, trihydrochlorideethylene, etc.), or other common light solvents such as acetonitryl, dioxane, etc. Acetone is a particularly interesting solvent. [0057] Surfactants are commonly used to avoid the aggregation of the particles when stored. Examples of surfactants that can be used are: lecithins, synthetic, anionic (e.g. sodium lauryl sulphate), cationic (e.g. quaternary ammonium) or non-ionic (e.g. sorbitan monoesters, containing or not polyoxyethylene residues, ethers formed from fatty alcohols and polyethylene glycol, polyoxyethylene-polypropylene glycol, etc.). Particularly interesting combinations include lipophilic surfactants with low hydrophilic-lipophilic (EHL) balance values (e.g. sorbitan esters—Span 20 or Span 60) and hydrophilic surfactants with high EHL values (ethoxylated sorbitan esters-Tween 80) or. indeed, merely a single non-ionic surfactant having a high EHL (such as Tween 80). [0058] In some embodiments, the prodrug conjugate can be formulated in a self-microemulsifying drug delivery system (SMEDDS). A self-microemulsifying drug delivery system can be described as an optically isotropic system of oil, surfactant and drug, which forms an oil in water microemulsion on gentle agitation in the presence of water. A SMEDDS for pharmaceutical application can thus be considered as a concentrate which is rapidly dispersed when introduced to the body to form an oil-in-water microemulsion. [0059] In some embodiments, the prodrug conjugate can be formulated in a solid lipid nanoparticle. Solid lipid nanoparticles can be prepared in any manner conventional in the art. such as. for example, as described in Stuchlik, M. and Zak, S. (Lipid-Based Vehicle for Oral Delivery, Biomed. Papers 145 (2): 17-26, (2001)). The solid lipid nanoparticle can be prepared in a hot homogenization process by homogenization of melted lipids at elevated temperature. In this process, the solid lipid is melted and the prodrug conjughate is dissolved in the melted lipid. A pre-heated dispersion medium is then mixed with the conjugate-loaded lipid melt, and the combination is mixed with a homogenisator to form a coarse pre-emulsion. High pressure homogenization is then performed at a temperature above the lipids melting point to produce an oil/water-nanoemulsion. The nanoemulsion is cooled down to room temperature to form solid lipid nanoparticles. [0060] Alternativley, the the solid lipid nanoparticles can be prepared in a cold homogenization process. In this process, the lipid is melted and the prodrug conjugate is dissolved in the melted lipid. The prodrug-loaded lipid is then solidified in liquid nitrogen or dry ice. The solid prodrug-lipid is ground in a powder mill to form 50-100 urn particles. The lipid particles are then dispersed in cold aqueous dispersion medium and homogenized at room temperature or below to form solid lipid nanoparticles. Antifungal agents [0061] As used herein, the term "antifungal agent" is intended to mean a substance capable of inhibiting or preventing the growth, viability and/or reproduction of a fungal cell. Preferable antifungal agents are those capable of preventing or treating a fungal infection in an animal or plant. A preferable antifungal agent is a broad spectrum antifungal agent. However, an antifungal agent can also be specific to one or more particular species of fungus. [0062] Examples of antifungal agents include, but are not limited to, azoles (e.g.. Fluconazole. Isavuconazole, Itraconazole, Ketoconazole, Miconazole, Clortrimazole, Voriconazole, Posaconazolc. Ravuconazole, etc.), polyenes (e.g., natamycin, Iucensomycin, nystatin, amphotericin B, etc.), echinocandins (e.g., Cancidas), pradimicins (e.g., beanomicins, nikkomycins, sordarins, allylamines. etc.), Triclosan, Piroctone, fenpropimorph, terbinafine, and derivatives and analogs thereof. Additional antifungal agents include those described, for example, in Int. Pat. Pub. No. WO2001/066551, No. WO2002/090354, No. WO2000/043390, No. WO2010/032652, No. WO2003/008391, No. WO2004/018485, No. WO2005/006860, No. WO2003/086271, No. WO2002/067880; in U.S. Pat. App. Pub. No. 2008/0194661, No. 2008/0287440, No. 2005/0130940. No. 2010/0063285, No. 2008/0032994, No. 2006/0047135, No. 2008/0182885; and in U.S. Pat. No. 6,812,238; No. 4,588,525; No. 6,235,728; No. 6,265,584; No. 4,942,162; and No. 6,362,172, content of all of which is incorporated herein by reference. [0063] In some embodiments, the antifungal agent is an azole based antifungal agent. By an azole based antifungal agent is meant an antifungal agent which comprises at least one azole in its structure. Preferred azoles include imidazoles and triazoles. Exemplary azole based antifungal agents include, but are not limited to, Fluconazole, Isavuconazole, Itraconazole, Ketoconazole. Miconazole. Clortrimazole, Voriconazole, Posaconazole, and Ravuconazole. In some embodiments, the azoic based antifungal agent is linked to the linker or the carrier by a ring-nitrogen of the azole moiety. [0064] In some embodiments, the antifungal agent comprises at least one free hydroxyl group. Exemplary antifungal agents which comprise a free hydroxyl group include, but are not limited to, Ciclopirox, Fluconazole, Voriconazole, Piroctone, Triclosan, Ravuconazole, and Isavuconazole. In some embodiments, antifungal comprising a free hydroxyl group is linked to the linker or the carrier by said free hydroxyl group. [0065] In some embodiments, the antifungal agent is an antifungal peptide. Antifungal peptides are well known in the art (see for example, De Lucca et al.. Rev. Iberoam. Micol. 17:116-120 (2000)). The antifungal peptide can be a naturally occurring peptide or an analog thereof, or it may be a synthetic peptide. As used herein, the term "analog" refers to a naturally occurring antifungal peptide that has been chemically modified to improve its effectiveness and/or reduce its toxic/side effects. Exemplary antifungal peptides can include, but are not limited to, syringomycins, syringostatins, syringotoxins, nikkomycins, echinocandins, pneumocadins, aculeacins, mulundocadins, cecropins, alpha-defensins, beta-defensins, novispirins, and combinations thereof. Other antifungal peptides include those described, for example, in U.S. Pat. No. 6,255,279 and U.S. Pat. App. Pub. No. 2005/0239709; No. 2005/0187151; No. 2005/0282755, and No. 2005/0245452, content all of which is incorporated herein by reference. [0066] As used herein, the terms "fungus" or "fungi" include a variety of nucleated, spore-bearing organisms which are devoid of chlorophyll. Examples include yeasts, mildews, molds, rusts, and mushrooms. Examples of fungi include, but are not limited to Aspergillus fumigates, Aspergillus flavus, Aspergillus nidulans, Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida lusitaniae, Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans, Issatchenkia orientalis, Coccidioides, Paracoccidioides, Histoplasma, Blastomyces, and Neurospora crassa. [0067] In some embodiments, fungus is of the genus Malassezia (e.g., M furfur, M pachydermatis, M. globosa, M. restricta, M. slooffiae. M. sympodialis, M. nana, M. yamatoensis. M dermatis, and M. obtuse). [0068] Without wishing to be bound by a theory, the Malassezia species causing most skin disease in humans, including the most common cause of dandruff and seborrhoeic dermatitis, is M globosa (though M. restricta and M. furfur are also involved). The skin rash of tinea versicolor (pityriasis versicolor) is also due to infection by this fungus. As the fungus requires fat to grow, it is most common in areas with many sebaceous glands: on the scalp, face, and upper part of the body. When the fungus grows too rapidly, the natural renewal of cells is disturbed and dandruff appears with itching (a similar process may also occur with other fungi or bacteria). [0069] Accordingly, in some embodiments, the antifungal agent is an antifungal agent effective against the fungus of genus Malassezia. In some further embodiments of this, the antifungal agent is an antifungal agent that is effective against the fungus M. globosa. [0070] In some embodiments, the antifungal agent is Itraconazole or Ketoconazole. Antibacterial agents [0071] As used herein, the term "antibacterial agent" is defined as a compound having either a bactericidal or bacteriostatic effect upon bacteria contacted by the compound. As used herein, the term "bactericidal" is defined to mean having a destructive killing action upon bacteria. As used herein, the term "bacteriostatic" is defined to mean having an inhibiting action upon the growth of bacteria. [0072] Examples of antibacterial agents include, but are not limited to, macrolides or ketolides such as erythromycin, azithromycin, clarithromycin, and telithromycin; beta-lactams including penicillin, cephalosporin, and carbapenems such as carbapenem, imipenem, and meropenem; monolactams such as penicillin G, penicillin V, methicillin, oxacillin, cloxacillin, dicloxacillin, nafcillin, ampicillin, amoxicillin, carbenicillin, ticarcillin, meziocillin, piperacillin, azlocillin, temocillin, cepalothin, cephapirin, cephradine, cephaloridine, cefazolin, cefamandole, cefuroxime, cephalexin, cefprozil, cefaclor, loracarbef, cefoxitin, cefmetazole, cefotaxime, ceftizoximc, ceftriaxone, cefoperazone, ceftazidime, cefixime, cefpodoxime, ceftibuten, cefdinir, cefpirome. cefepime, and astreonam; quinolones such as nalidixic acid, oxolinic acid, norfloxacin, pefloxacin, enoxacin, ofloxacin, levofloxacin, ciprofloxacin, temafloxacin, lomefloxacin, fleroxacin, grepafloxacin, sparfloxacin, trovafloxacin, clinafloxacin, gatifloxacin, moxifloxacin, sitafloxacin, ganefloxacin, gemifloxacin and pazufloxacin; antibacterial sulfonamides and antibacterial sulphanilamides, including para-aminobenzoic acid, sulfadiazine, sulfisoxazole, sulfamethoxazole and sulfathalidine; aminoglycosides such as streptomycin, neomycin, kanamycin, paromycin, gentamicin. tobramycin, amikacin, netilmicin, spectinomycin, sisomicin, dibekalin and isepamicin; tetracyclines such as tetracycline, chlortetracycline, demeclocycline, minocycline, oxytetracycline, methacycline, doxycycline; rifamycins such as rifampicin (also called rifampin), rifapentine, rifabutin, bezoxazinorifamycin and rifaximin; lincosamides such as lincomycin and clindamycin; glycopeptides such as vancomycin and teicoplanin; streptogramins such as quinupristin and daflopristin; oxazolidinones such as linezolid; polymyxin, colistin and colymycin; trimethoprim, bacitracin, and phosphonomycin. [0073] In some embodiments, the antibacterial agent is effective against P. acnes. [0074] In some embodiments, the antibacterial agent is an antiacne agent. As used herein, the term "antiacne agent" refers to any chemical that is effective in the treatment of acne and/or the symptoms associated therewith. Antiacne agents are well known in the art such as U.S. Pat. App. Pub. No. 2006/ 0008538 and U.S. Pat. No. 5,607,980, content of both of which is incorporated herein by reference. Examples of useful antiacne agents include, but are not limited to keratolytics, such as salicylic acid, derivatives of salicylic acid, and resorcinol; retinoids, such as retinoic acid, tretinoin, adapalene, tazarotene; sulfur-containing D- and L-amino acids and their derivatives and salts: lipoic acid; antibiotics and antimicrobials, such as benzoyl peroxide, triclosan, chlorhexidine gluconate, octopirox, tetracycline, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'-trichlorobanilide, nicotinamide, tea tree oil, rofecoxib, azelaic acid and its derivatives, phenoxyethanol, phenoxypropanol, phenoxisopropanol, ethyl acetate, clindamycin, erythromycin, and meclocycline; sebostats, such as flavonoids; and bile salts, such as scymnol sulfate and its derivatives, deoxycholatc. and cholate; and combinations thereof. These agents are well known and commonly used in the field of personal care. [0075] Additionally, the antiacne agent may be an antimicrobial peptide having activity against P. acnes. Antimicrobial peptides are ubiquitous in nature and play an important role in the innate immune system of many species (Zasloff, Nature 415:389-395 (2002) and Epand et al„ Biochim Biophys Acta 1462:11-28 (1999)). The antimicrobial peptide may be a naturally occurring peptide or an analog thereof, or it may be a synthetic peptide. As used herein an "analog" refers to a naturally-occurring antimicrobial peptide that has been chemically modified to improve its effectiveness and/or reduce its toxic side effects. The antimicrobial peptide may be a peptide known to be effective against Gram positive bacteria. Non-limiting examples include lantibiotics, such as nisin, subtilin, epidcrmin and gallidermin; defensins; attacins, such as sarcotoxin; cecropins, such as cecropin A, bactericidin, and lepidopteran; magainins; melittins; histatins; brevinins; and combinations thereof. Additionally, antimicrobial peptides having activity against P. acnes have been reported, for example, in U.S. Pat. App. Pub. No. 2005/0282755; No. 2005/02455452; andNo.2005/0209157, and U.S. Pat. No. 6,255,279, content of all of which is incorporated herein by reference. Suitable examples of antimicrobial peptides having reported activity against P. acnes include, but are not limited to, novispirins (Hogenhaug, supra), and those described in U.S. Pat. App. Pub. No.2007/0265431, content of which is incorporated herein by reference. [0076] In some embodiments, the antibacterial agent is clindamycin. Carriers [0077] A wide variety of entities, e.g., carriers, can be coupled to an antifungal or antibacterial agent. Carriers can include naturally occurring molecules, or recombinant or synthetic molecules. Carriers can include, but are not limited to, polymers; carboxylated polymers, hydroxylated polymer, polyethylene glycols (PEG); mono- or di-carboxylated PEGs; fatty acids comprising a C6-C26 alkyl. which can be optionally substituted and/or interspersed with a heteroatom, aryl, heteroaryl, cyclyl, or heterocyclyl; alcohols comprising a C6-C26 alkyl, which can be optionally substituted and/or interspersed with a heteroatom, aryl, heteroaryl, cyclyl, or heterocyclyl; glycerol; derivatives of glycerol, amino acids; nucleic acids; antibacterial agents; antifungal agents; alpha-hydroxy acids; beta-hydroxy acids; diacids; oxadiacids; peptides; peptidomimetics; polylysine, cationic groups; spermine; spermidine; polyamine; thyrotropin; melanotropin; lectin; glycoprotein; surfactant protein A; mucin; glycosylated polyaminoacids; transferrin, aptamer; immunoglobulins (e.g., antibodies); insulin, transferrin; albumin; sugar; lipophilic molecules (e.g, steroids, bile acids, cholesterol, cholic acid, and fatty acids); vitamin A; vitamin E; vitamin K; vitamin B; folic acid; B12; riboflavin; biotin; pyridoxal; vitamin cofactors; lipopolysaccharide; hormones and hormone receptors; lectins; carbohydrates; multivalent carbohydrates; radiolabeled markers; fluorescent dyes; and any combinations thereof. A carrier can be substituted with one or more (e.g., one, two, three, four, five, six, seven, eight, nine, ten, or more) substituents. A carrier can be a therapeutic agent. [0078] In some embodiments, the carrier comprises a free carboxylic or a free hydroxyl group. This carboxylic or hydroxyl group can be the attachment point for the linker. [0079] In some embodiments, the carrier is a fatty acid comprising 6-25 carbons. In some embodiments, the carrier is a fatty acid selected from the group consisting of Caprylic acid, Pelargonic acid. Capric acid, Undecylic acid, Laurie acid, Tridecylic acid, Myristic acid, Pentadecylic acid, Palmitic acid, Heptadecanoic acid, Stearic acid, Nonadecylic acid, Arachidic acid, Heneicosylic acid, Behenic acid, Tricosylic acid, Lignoceric acid, Pentacosylic acid, Cerotic acid, Heptacosylic acid, Montanic acid, Myristoleic acid, Palmitoleic acid, Sapienic acid, Oleic acid, Elaidic acid. Vaccenic acid, Linoleic acid, Linoelaidic acid, α-Linolenic acid, -Linolenic acid, Arachidonic acid. Eicosapentaenoic acid, Erucic acid, Docosahexaenoic acid, cis-11-octadecenoic acid, cis-11-eicosenoic acid, undecylenic acid, cis-13-docosenoic acid, neoheptanoic acid, neononanoic acid, neodecanoic acid, isostearic acid, 10-undecenoic acid, and adapalene. [0080] In some embodiments, the carrier is an alkyl alcohol, e.g., a C6-C25 alkyl alcohol. In some embodiements, the carrier is an alkyl alcohol selected from the group consisting of undecanol. lauryl alcohol, myrsityl alcohol, cetyl alcohol, oleyl alcohol. [0081] In some embodiments, the carrier is a polyethylene glycol (PEG) or an analog or derivative thereof. A PEG carrierr can be of the general formula -O-CH2CH2[OCH2CH2]aR. wherein a is 1-500 and R can be H, OH, O-alkyl (e.g. O-CH3), amino, alkylated amino, protected amino group.. Suitable PEGs include, but are not limited to, PEG having an average molecular weight ranging from about 200 g/mole to about 30,000 g/mole. [0082] In some embodiments, the carrier is a biocompatible polymer. As used herein, the term "biocompatible" means exhibition of essentially no cytotoxicity or immunogenicity while in contact with body fluids or tissues. As used herein, the term "polymer" refers to oligomers, co-oligomers, polymers and co-polymers, e.g., random block, multiblock, star, grafted, gradient copolymers and combination thereof. [0083] The term "biocompatible polymer" refers to polymers which are non-toxic, chemically inert, and substantially non-immunogenic when used internally in a subject and which are substantially insoluble in blood. The biocompatible polymer can be either non-biodegradable or preferably biodegradable. Preferably, the biocompatible polymer is also noninflammatory when employed in situ. [0084] Biodegradable polymers are disclosed in the art. Examples of suitable biodegradable polymers include, but are not limited to, linear-chain polymers such as polylactides, polyglycolides, polycaprolactones, copolymers of polylactic acid and polyglycolic acid, polyanhydrides, polyepsilon caprolactone, polyamides, polyurethanes, polyesteramides, polyorthoesters, polydioxanones, polyacetals, polyketals, polycarbonates, polyorthocarbonates, polydihydropyrans, polyphosphazenes, polyhydroxybutyrates, polyhydroxyvalerates, polyalkylene oxalates, polyalkylene succinates. poly(malic acid), poly(amino acids), polyvinylpyrrolidone, polyethylene glycol, polyhydroxycellulose, polymethyl methacrylate, chitin, chitosan, copolymers of polylactic acid and polyglycolic acid, poly(glycerol sebacate) (PGS), and copolymers, terpolymers, and copolymers including one or more of the foregoing. Other biodegradable polymers include, for example, gelatin, collagen, silk, chitosan, alginate, cellulose, poly-nucleic acids, etc. [0085] Suitable non-biodegradable biocompatible polymers include, by way of example, cellulose acetates (including cellulose diacetate), polyethylene, polypropylene, polybutylene, polyethylene terphthalate (PET), polyvinyl chloride, polystyrene, polyamides, nylon, polycarbonates, polysulfides, polysulfones, hydrogels (e.g., acrylics), polyacrylonitrile, polyvinylacetate, cellulose acetate butyrate, nitrocellulose, copolymers of urethane/carbonate, copolymers of styrene/ maleic acid, poly(ethylenimine), Pluronic (Poloxamers 407, 188), Hyaluron, heparin, agarose, Pullulan, andcopolymers including one or more of the foregoing, such as ethylene/vinyl alcohol copolymers (EVOH). [0086] In some embodiments, the biocompatible polymer is a copolymer of polylactic acid and polyglycolic acid, poly(glycerol sebacate) (PGS), poly(ethylenimine), Pluronic (Poloxamers 407, 188), Hyaluron, heparin, agarose, or Pullulan. [0087] In some embodiments, the carrier is an amino acid or a peptide. As used herein, the term "peptide" refers to two or more amino acids joined to each other by amide bonds or modified amide bonds or modified peptide linkages. A peptide carrier can be linked by its N-terminus amino group, C-terminus carboxylic group, or a functional group (e.g, amino, hydroxyl, thiol, carboxylic) at a side chain of an amino acid in the peptide. In some embodiments, a peptide carrier is linked by its C-terminus carboxylic group. In some embodiments, peptide comprises 2-20 aminoacids. In one embodiment, the peptide comprises 2-10 aminoacids. A peptide can comprise an amino acid selected from the group consisting of alanine; argnine; asparagine; aspartic acid; cysteine; glutamic acid; glutamine; glycine; histadine; isoleucine; leucine; lysine; methionine; phenylalanine; proline; serine; threonine; tryptophan; tyrosine; valine; homocysteine; phosphoserine; phosphothreonine; phosphotyrosine; hydroxyproline; y-carboxyglutamate; hippuric acid; octahydroindole-2-carboxylic acid; statine; l,2,3,4,-tetrahydroisoquinoline-3-carboxylic acid; penicillamine (3-mercapto-D-valine); ornithine (Orn); citruline; alpha-methyl-alanine; para-benzoylphenylalanine; para-aminophenylalanine; p-fluorophenylalanine; phenylglycine; propargylglycine; N-methylglycins (sarcosine, Sar); and tert-butylglycine; diaminobutyric acid; 7-hydroxy-tetrahydroisoquinoline carboxylic acid; naphthylalanine; biphenylalanine; cyclohexylalanine; amino-isobutyric acid (Aib); norvaline; norleucine (Nle); tert-leucine; tetrahydroisoquinoline carboxylic acid; pipecolic acid; phenylglycine; homophenylalanine; cyclohexylglycine; dehydroleucine; 2,2-diethylglycine; 1-amino-1-cyclopentanecarboxylic acid; 1-amino-l-cyclohexanecarboxylic acid; amino-benzoic acid; amino-naphthoic acid; gamma-aminobutyric acid; difluorophenylalanine; nipecotic acid; N-a-imidazole acetic acid (IMA); thienyl-alanine; t-butylglycine; desamino-Tyr; aminovaleric acid (Ava); pyroglutaminic acid (