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Crystalline Form Of Dihydro 2,3 Benzodiazodiazepine Derivative.
Abstract: A crystalline form of (R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-l,3-dioxolo[4,5-h][ 2,3]benzodiazepine having an X-ray powder diffraction pattern with d spacings at 12.78, 9.48, 8.99, 8.64, 8.23, 6.39, 6.27. 5.73, 4.01 and 3.96 A'. The compound is useful as an AMPA antagonist.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
30 August 1995
Publication Number
08/05
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2007-05-16
Renewal Date
Applicants
ELI LILLY AND COMPANY
A CORPORATION OF THE STATE OF INDIANA, U.S.A, HAVING A PRINCIPAL PLACE OF BUSINESS AT LILLY CORPORATE CENTRE ,CITY OF INDIANAPOLIS, STATE OF INDIANA,
Inventors
1. BENJAMIN ALAN ANDERSON
1644 CATALINA WAY, ZIONSVILLE
INDIANA 46077
2. MARVIN MARTIN HANSEN
6409 FORREST COMMONS BOULEVARD INDIANAPOLIS, INDIANA 46227,
3. JEFFREY THOMAS VICENZI
49 TIMBER LANR, BROENSBURG, INDIANA 46112,
4. DAVID LEE VARIE
5363 MOHICAN ROAD, INDIANAPOLIS, INDIANA 46220,
5. MILTON JOSEPH ZMIJEWSKI, JUNIOR
10152 PARTRIDGE, CARMEL, INDIANA 46033,
6. EDWARD GRANT GROLEAU
1025 WEST 78TH STREET, INDIANAPOLIS, INDIANA 46260,
Specification
-1A-
This invention relates to a novel physical form of a dihydro-2,3-benzodiazepine derivative useful as a pharmaceutical in the treatment of disorders of the nervous system.
European patent application publication number EP-Al-0492485 discloses the compound 1-(4-aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine. The compound is a potent and selective antagonist of the excitatory amino acid AMPA receptor and is believed to have the ability to treat a variety of neurological disorders. The (R)-enantiomer of this compound hereinafter referred to as
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 1045-cal-1995-granted-specification.pdf | 2011-10-07 |
| 2 | 1045-cal-1995-granted-form 2.pdf | 2011-10-07 |
| 3 | 1045-cal-1995-granted-examination report.pdf | 2011-10-07 |
| 4 | 1045-cal-1995-granted-description (complete).pdf | 2011-10-07 |
| 5 | 1045-cal-1995-granted-claims.pdf | 2011-10-07 |
| 6 | 1045-CAL-1995-CORRESPONDENCE.pdf | 2011-10-07 |
| 7 | 01045-cal-1995 reply f.e.r.pdf | 2011-10-07 |
| 8 | 01045-cal-1995 letters patent.pdf | 2011-10-07 |
| 9 | 01045-cal-1995 g.p.a.pdf | 2011-10-07 |
| 10 | 01045-cal-1995 form-5.pdf | 2011-10-07 |
| 11 | 01045-cal-1995 form-3.pdf | 2011-10-07 |
| 12 | 01045-cal-1995 form-2.pdf | 2011-10-07 |
| 13 | 01045-cal-1995 form-18.pdf | 2011-10-07 |
| 14 | 01045-cal-1995 form-13.pdf | 2011-10-07 |
| 15 | 01045-cal-1995 form-1.pdf | 2011-10-07 |
| 16 | 01045-cal-1995 description(complete).pdf | 2011-10-07 |
| 17 | 01045-cal-1995 correspondence.pdf | 2011-10-07 |
| 18 | 01045-cal-1995 claims.pdf | 2011-10-07 |
| 19 | 01045-cal-1995 abstract.pdf | 2011-10-07 |
| 20 | 1045-CAL-1995-19-01-2023-ALL DOCUMENTS.pdf | 2023-01-19 |