DESC:FIELD OF THE INVENTION
The present invention comprises curcuminoid clear liquid compositions suitable for filling in hard capsules for human administration orally. The compositions of this invention show enhanced solubility, better stability and improved bioavailability.

BACKGROUND OF THE INVENTION
Despite considerable efforts, the prevalence of complex multigenic human diseases such as cardiovascular diseases, metabolic diseases, cancer, and neurological diseases have not decreased significantly in recent years. A number of monotargeted “smart” drugs have emerged over the past decade; however, the aforementioned diseases are caused by perturbations of multiple signaling pathways. These features of monotargeted drugs underscore the importance of multitargeted, innocuous, inexpensive, and readily available dietary agents or nutraceuticals for the prevention and treatment of human diseases. Curcumin is one such widely studied nutraceutical. It is safe, tolerable, and non-toxic even at doses up to 8 g per day. Poor bioavailability is a major limitation to the therapeutic utility of curcumin (AAPS J. 2013 Jan; 15(1): 195–218). Turmeric contains up to 5% of curcuminoids of which curcumin is main curcuminoid. Other curcumnoids include demethoxycurcumin and bisdemethoxycurcumin

Poor bioavailability of curcuminoids is attributed to poor solubility in water, low permeability and faster elimination. Piperine, a major component of black pepper, known as inhibitor of hepatic and intestinal glucuronidation is shown to increase the bioavailability of curcumin. This effect of piperine on the pharmacokinetics of curcumin has been shown to be much greater in humans than in rats (Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers is presented in Planta Med. 1998; 64:353–356.)

US8835509B2 disclosed a self nano emulsifying drug delivery formulation for curcuminoids. It contains curcuminoid, an oil phase of propylene glycol monocaprylate present in a range of 25-33% (w/w), a surfactant selected from a polyoxyethylene or polyethoxyl derivative of a vegetable oil present in a range of 35-45% (w/w) and another surfactant to be used as co-surfactant(s) present in a range of 8-16% (w/w).

US20160128939 disclosed micelles loaded with curcumin. More specifically it disclosed a solubilisate composed of curcumin in a quantity of less or equal to 10% by weight; and at least one emulsifier having an HLB value in the range between 13 and 18, namely polysorbate 80, or polysorbate 20, or a mixture of polysorbate 20 and polysorbate 80, wherein the average diameter of the micelles loaded with curcumin is between 5 nm and 40 nm.

US4138212 disclosed a process in which a water soluble curcumin coloring agent is produced from ground turmeric root by washing the root with a soap solution in which the curcumin dissolves. A subsequent treatment of the solution with acid precipitates the curcumin and produces a paste or putty which is dispersible in fatty based substances. Specifically it disclosed a process which involves circulating a soap solution through a heated tank which contains ground turmeric root until the ground rootstock exhibits little or none of its original dominant orange-brown color. At this time, the curcumin is dissolved in the soap solution and is a dark brown-maroon syrupy viscous substance. After filtering, it is ready for use directly as a water soluble coloring agent which requires dissolving a small quantity in water to impart an intense yellow color to the water. A batch of the dark viscous fluid is treated with acid until it turns to a yellow precipitant which settles out of the water solvent. The clear water and any other solutes which may be present are filtered out, leaving a paste or putty like agglomeration which is bright yellow. This putty is directly usable as a colorant in fatty materials such as oleo margarine and vegetable oil shortenings and many other food products.

US6238696 disclosed a process for providing non-lipid, liquid-form herbal extracts in a vegetable gelatin, HPMC, or any other cellulose derivative capsule. The process includes extracting an herbal plant material with an alcohol or aqueous/alcohol to provide an aqueous alcoholic herbal extract. This aqueous alcoholic herbal extract is transferred to a liquid glycerin-based herbal extract through rotary evaporation or other condensing equipment. This transfer of solution is accomplished by adding vegetable glycerin while the water and alcohol are being evaporated. The herbal extract is maintained in solution or dispersed in the alcohol mixture. The resulting herbal extract contains a moisture content of no more than 10 percent by weight, and preferably no more than 5 percent by weight. The herb extract is then encapsulated in vegetable gelatin, HPMC, or any other cellulose derivative capsule. The document mentions that herbal extracts in a fixed oil base filled into gelatin capsule have received little recognition. Problems of miscibility and absorption are numerous with such systems.

US9192644 disclosed lipid micelles, microemulsions or microencapsulated oils of curcuminoid. The compositions contain a curcuminoid, an antioxidant, and a water-solubilizing, pharmaceutically acceptable carrier, and optionally a glucuronidation inhibitor. The solubilization is achieved by forming curcuminoid-lipid micelles, and the composition is provided as a microemulsion or solid lipid nanoparticles (SLN). Alternatively, the curcuminoid is dissolved in an edible oil, which can then be microencapsulated or emulsified. The disclosed composition can be provided as a gel, capsule, liquid, or other pharmaceutically acceptable form.

US20170042833A1 claims a method of decreasing inflammation comprising administering a composition for enhanced bioavailability of curcumin, demethoxycurcumin and bisdemethoxycurcumin, the composition comprising a curcuminoid mixture and essential oil of turmeric, wherein the curcuminoid mixture comprises curcumin, demethoxycurcumin and bisdemethoxycurcumin in a weight ratio of curcumin:demethoxycurcumin: bisdemethoxycurcumin of about 0.8:1:1 to about1:1.1:1.2, wherein the essential oil of turmeric comprises about 45% Ar-turmerone, and, wherein a weight ratio of the curcuminoid mixture to essential oil of turmeric ranges from about 1:3 to about 99:1.

Indian patent application 2553/MUM/2010 relates to stable liquid pharmaceutical compositions of curcumin. But these liquids are not suitable for filling in hard capsules as those contain propylene glycol and ethyl alcohol.

Though prior art mention about the herbal extracts, self nano emulsifying drug delivery formulation, micelles, microemulsions or microencapsulated oils of curcuminoid, the solubilization and stability of curcuminoid in liquid compositions has always remained a major challenge till date. Liquid compositions are expected to give better bio-availability.

Till date there is no clear liquid filled hard capsules for curcumin in the market. The available conventional formulations are generally solids/ semi-solids filled into hard capsules or suspensions filled into Soft gelatin capsules. The major drawbacks of solid powder filled capsules is the risk of subsequent airborne powder dust created during manufacturing. Lesser homogeneity of products due to powders and granules filled in capsules, complex process for scaling up on a commercial level, a variety of excipients and increased manufacturing steps and machines are required for filling and sealing of capsules. Dissolution profile of poorly water-soluble drugs and also controlled drug delivery cannot be efficiently achieved with solid powdered filled capsule formulations.

Liquids filled in clear, transparent hard capsules of HPMC (vegetable origin) or gelatin will give confidence to user as any changes in the filled solution can be observed without opening the capsule besides enhancing bioavailability. There is need for such liquids which can be filled in hard capsules while maintaining acceptable stability.

Obtaining clear solution of curcumin by dissolving it in appropriate surfactants and solubilisers; and fill it in hard capsules by maintaining the shell integrity and compatibility is a major challenge. Clear solution of formulation when filled in transparent hard gelatin and HPMC capsules make the evaluation process less complex. The formulation can be monitored for any physical instability like clarity, colour change, deformation of shell etc via naked observation. Thus current invention provides clear curcuminoid liquid compositions that can be filled in hard capsules which overcome the above challenges faced for conventional formulations.

SUMMARY OF THE INVENTION:
Present invention in its various aspects provides clear curcuminoid liquid compositions that can be filled in transparent hydroxypropyl methylcellulose (HPMC) and hard gelatin capsules.

In first aspect, it provides a clear curcuminoid liquid composition for filling in transparent HPMC and hard gelatin capsules comprising curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and polyethylene glycol 600.

In second aspect, it provides a clear curcuminoid liquid composition for filling in transparent hard gelatin capsules comprising curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and diethylene glycol monoethyl ether.

In third aspect, it provides a clear curcuminoid liquid composition for filling in transparent hard gelatin capsules comprising curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, caprylocaproyl Polyoxyl-8 glycérides, and low molecular weight polyethylene glycols.

DESCRIPTION OF THE INVENTION:
Current invention disclose the clear curcuminoid liquid compositions suitable for filling in hard capsules with increased solubility, improved stability, enhanced bioavailability
The liquid compositions can be filled in hard capsules for oral delivery.

The term “liquid” mentioned herein general refer to the compositions which exhibit flowability. They may be solutions, suspensions, emulsions, thixotropic gels, self-emulsifying systems. Further they include semisolid matrix or hot melts flowable up to the temperature 70°C for filling in hard capsules. Hard capsules also enable filling another capsule, small tablets or pellets in addition to the liquid.

The invention in its various aspects provides clear curcuminoid liquid compositions that can be filled in transparent HPMC and hard gelatin capsules. These are the clear curcuminoid liquid compositions having curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids formulated with the judiciously selected ingredients such as polyethylene glycol 600, diethylene glycol monoethyl ether, caprylocaproyl Polyoxyl-8 glycérides, and low molecular weight polyethylene glycols. The turmeric extract powder include the aqueous extract evaporated to dryness and containing at least 95% of curcuminoids.

Accordingly, in first aspect the invention provides a clear curcuminoid liquid composition that can be filled in transparent HPMC and hard gelatin capsules. It comprises curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and polyethylene glycol 600.

In these clear curcuminoid liquid composition the polyethylene glycol 600 is present in the volume to weight percentage ratio of at least 0.75 with respect to curcuminoids. The 0.3 ml volume of polyethylene glycol 600 is sufficient to give clear liquid solution for 40 mg of curcuminoids.

These compositions can further include low molecular weight polyethylene glycols. The low molecular weight polyethylene glycols include polyethylene glycol 200 and polyethylene glycol 400.

In second aspect of the invention, it provides a clear curcuminoid liquid composition that can be filled in transparent hard gelatin capsules. It comprises curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and diethylene glycol monoethyl ether. In these clear curcuminoid liquid composition the diethylene glycol monoethyl ether is present in the volume to weight percentage ratio of at least 1 with respect to curcuminoids. The 0.3 ml volume of diethylene glycol monoethyl ether of is sufficient to give clear liquid solution for 30 mg of curcuminoids.

These compositions also can further include low molecular weight polyethylene glycols. The low molecular weight polyethylene glycols include polyethylene glycol 200 and polyethylene glycol 400.

In third aspect, the invention provides a clear curcuminoid liquid composition for filling in transparent hard gelatin capsules comprising curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, caprylocaproyl Polyoxyl-8 glycérides, and low molecular weight polyethylene glycols.
The low molecular weight polyethylene glycols are preferably selected from polyethylene glycol 200 and polyethylene glycol 400.

In these clear curcuminoid liquid composition the caprylocaproyl Polyoxyl-8 glycérides, polyethylene glycol 200 and polyethylene glycol 400 are present in the volume to weight percentage ratio of at least 0.6, 0.4 and 0.6 respectively with respect to curcuminoids. The 0.3 ml volume of caprylocaproyl Polyoxyl-8 glycérides, 0.2 ml volume of polyethylene glycol 200 and 0.3 ml volume of polyethylene glycol 400 are sufficient to give clear liquid solution for 50 mg of curcuminoids.

The clear curcuminoid liquid compositions achieved in present invention by the judicious selection of the surfactants and solubilisers. The curcuminoid shows insolubility in the conventionally used oils, surfactants and triglycerides including Soyabean oil, Sunflower oil, Sesame oil, Capyrol 90, Labrafil, Labrafac, Labrasol, Lauroglycol 90, Kollisolv MCT 70, Kollisolv P 124, Kolliphor EL, Kollisolv PEG 300, Kollihphor RH 40, Kolliphor HS 15, PVPK 30, Tween 80 (Polysorbate 80), Caprylic Capric Triglyceride (Harilol 538) and Maisicine (Glyceryl monolinoleate).

The surfactant like caprylocaproyl Polyoxyl-8 glycérides, ethyl oleate, transcutol HP, harilol and low molecular weight PEGs are suitable to form clear liquid solution in a desired concentration range of active. However, ethyl oleate and harilol doesn’t show compatibility with the capsule shell materials.

The clear curcuminoid liquid compositions according to current invention are compatible with capsule shells and exhibited consistency in clarity at least up to 3 months.

Filling of these hard capsules is simpler, compact and economical process than soft gelatin capsules (SGC). Hard capsules have thinner walls and need overall four to five times lesser gelatin than SGC. It is not possible to fill hot melts in SGC. These can lose shape in topical and humid climates. Hard capsules reduce the exposure to oxygen and can be purged with Nitrogen. It also reduces product migration and odour into the shell. The ability to fill the capsules on semiautomatic or automatic equipment is a recent development. Two sealing technology options are available to pharmaceutical and biotech companies developing liquid-filled hard capsule products. Capsule banding, where a visible band of gelatin or HPMC is applied around the joint between the capsule – thus sealing the caps to the body of the capsule – is one approach often favoured for client branding (band colouring), dose identification, or tamper-evidence considerations. The second option is “Fusion” technology, which utilizes the application of a fine micro-spray of sealing solution around the joint between the body and the cap of the capsule so that the contacting surfaces of the cap and the body are effectively fused together.

These liquid filled hard capsules have stronger barrier properties with respect to oxidation and temper ability.

Liquid filled hard capsules showed improved bioavailability, it reduces the food effects, it stabilises the active pharmaceutical ingredient with respect to oxygen, light and moisture exposure, and improve the dose uniformity of curcuminoid and reduce the risk of handling of dry powder curcuminoid.

Another advantage of these liquid filled capsules is it showed the content uniformity for low dose, highly potent curcuminoid. They also improved the safety of the workers because they reduce the fine particles exposure.

Liquid filled capsules allow active ingredient to be solubilised or suspended in a liquid media within the capsule fill. The Liquid filled capsules could be monitored for their appearance, uniformity and stability.

The foregoing description of the specific embodiments will so fully reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and/or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope.

Examples:
Curcumin dry extract powder yellowish to orange in colour or Turmeric extract powder containing not less than 95% of curcuminoids was procured from the manufacturer. This is referred as curcuminoids powder. The powder is solubilised as per following examples. The solution was filled on semiautomatic liquid filling machine for hard capsules and band sealing was applied using gelatin band on the same machine. Transparent capsules were used. The volume that could be filled in 00 size hard capsule is 0.8 ml.
Following compositions were taken for manufacturing and the observations were determined and reported as below:
Example 1: Clear curcuminoid liquid composition filled in transparent HPMC and hard gelatin capsules. Capsules size 0 was used.

1A 1B
Sr. No. Components Amount Amount
1. Drug (mg) 30 40
2. PEG 600 ( ml) 0.3 0.3
Total Volume 0.3 0.3
Observation: Clear, homogenous red solution with no incompatibilities with the HPMC and Gelatin capsule shell. The solutions were stable for 3 months at room temperature.

Example 1C
Sr. No. Components Amount
1. Drug (mg) 30
2. PEG 200 (ml) 0.1
3. PEG 400 (ml) 0.1
4. PEG 600 ( ml) 0.3
Total Volume 0.5
Observation: Clear, homogenous red solution with no incompatibilities with the HPMC and Gelatin capsule shell. The solutions were stable for 3 months at room temperature.

Example 2: Clear curcuminoid liquid composition filled in hard gelatin capsules. Capsules size 0 was used.
Example 2A
Sr. No. Components Amount
1. Drug (mg) 30
2. diethylene glycol monoethyl ether i.e. Transcutol HP (ml) 0.3
Total Volume 0.3
Observation: Clear, homogenous red solution. The batches were found to be compatible with Gelatin capsule shell. The solutions were stable for 3 months at room temperature.

Example 2B
Sr. No. Components Amount
1. Drug (mg) 30
2. Transcutol HP (ml) 0.3
3. PEG 200 (ml) 0.1
Total Volume 0.4
Observation: Clear, homogenous red solution. The batches were found to be compatible with Gelatin capsule shell. The solutions were stable for 3 months at room temperature.

Example 2C
Sr. No. Components Amount
1. Drug (mg) 30
2. Transcutol HP (ml) 0.3
3. PEG 400 (ml) 0.1
Total Volume 0.4
Observation: Clear, homogenous red solution. The batches were found to be compatible with Gelatin capsule shell. The solutions were stable for 3 months at room temperature.

Example 2D
Sr No.
2D Components Amount
1. Drug (mg) 30
2. Transcutol HP (ml) 0.3
3. PEG 600 ( ml) 0.1
Total Volume 0.4
Observation: Clear, homogenous red solution. The batches were found to be compatible with Gelatin capsule shell. The solutions were stable for 3 months at room temperature.

Example 2E
Sr No.
2E Components Amount
1. Drug (mg) 30
2. Transcutol HP (ml) 0.3
3. PEG 200 (ml) 0.1
4. PEG 400 (ml) 0.1
5. PEG 600 ( ml) 0.1
Total Volume 0.6
Observation: Clear, homogenous red solution. The batches were found to be compatible with Gelatin capsule shell. The solutions were stable for 3 months at room temperature.

Example 3: Clear curcuminoid liquid composition filled in hard gelatin capsules. Capsules size 00 was used.
Example 3E
Sr No.
3A Components Amount
1. Drug (mg) 50
2. caprylocaproyl Polyoxyl-8 glycérides i.e.
Labrasol ALF (ml) 0.3
3. PEG 200 (ml) 0.2
4. PEG 400 (ml) 0.3
Total Volume 0.8
Observation: Clear, homogenous red solution. The batches were found to be compatible with Gelatin capsule shell. The solutions were stable for 3 months at room temperature.

The drug release study using dissolution by HPLC method for some of the above compositions is mentioned below:
Chromatographic system
Detector: UV-Vis 420 nm
Column: 4.6 mm * 25 cm, 5 µm packing L1
Flow rate: 1 mL/min
Injection size: 20 µL
Mobile Phase: 1mg/ml citric acid in water: Tetrahydrofuran (60:40)

Dissolution method
Medium: Distilled water containing 1% w/v SLS; 900 mL
Apparatus: USP Apparatus II Paddle Type

Table indicating % Drug release:
Sr.No. Time in mins % Drug release (% Curcuminoids release)
Transparent hard gelatine capsules Transparent HPMC Capsules Transparent hard gelatine capsules

Clear curcuminoid liquid composition Formula = [30mg drug, 0.3g PEG 600 + 0.1g PEG 400 + 0.1g PEG 200]
filled in gelatin capsule Clear curcuminoid liquid composition Formula =
[30mg drug, 0.3g PEG 600 + 0.1g PEG 400 + 0.1g PEG 200]
filled in HPMC capsule
Clear curcuminoid liquid composition Formula = [30mg drug, 0.3g Transcutol HP + 0.1g PEG 600 + 0.1g PEG 400 + 0.1g PEG 200]
filled in gelatin capsule Formula =
Std. drug (95% curcumin)
1 0 min 0 0 0 0
2 5 mins 54.66 32.33 23.33 7.66
3 10 mins 95.33 89.66 84.66 10.66
4 15 mins 97.66 93 95.33 11.33
5 30 mins 99.66 94 97.66 15
6 60 mins 101 93 100.3 19

In vitro Drug release pattern

The product according to the current invention showed better release profile than the standard.
,CLAIMS:I/We Claim:
1. A clear curcuminoid liquid composition for filling in transparent HPMC and hard gelatin capsules comprising curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and polyethylene glycol 600.

2. The clear curcuminoid liquid composition for filling in transparent HPMC and hard gelatin capsules as claimed in claim 1, wherein the polyethylene glycol 600 is present in the volume to weight percentage ratio of at least 0.75 with respect to curcuminoids.

3. The clear curcuminoid liquid composition for filling in transparent HPMC and hard gelatin capsules as claimed in claim 1 and 2 wherein said composition has 30 mg curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and 0.3 ml of polyethylene glycol 600.

4. The clear curcuminoid liquid composition for filling in transparent HPMC and hard gelatin capsules as claimed in claim 1 and 2 wherein said composition has 40 mg curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and 0.3 ml of polyethylene glycol 600.

5. The clear curcuminoid liquid composition for filling in transparent HPMC and hard gelatin capsules as claimed in claims 1 and 2, wherein said compositions further include low molecular weight polyethylene glycols.

6. The clear curcuminoid liquid composition for filling in transparent HPMC and hard gelatin capsules as claimed in claim 5, wherein said composition has 30 mg of curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, 0.3 ml polyethlene glycol 600, 0.1 ml polyethylene glycol 400 and 0.1 ml polyethylene glycol 200.

7. A clear curcuminoid liquid composition for filling in transparent hard gelatin capsules comprising curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and diethylene glycol monoethyl ether.

8. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claim 7, wherein the diethylene glycol monoethyl ether is present in the volume to weight percentage ratio of at least 1 with respect to curcuminoids.

9. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claims 7 and 8, wherein said composition has 30 mg of curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids and 0.3 ml diethylene glycol monoethyl ether.

10. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claims 7 and 8, wherein said compositions further include low molecular weight polyethylene glycols.

11. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claim 10, wherein said composition has 30 mg of curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, 0.3 ml diethylene glycol monoethyl ether and 0.1 ml polyethylene glycol 200.

12. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claim 10, wherein said composition has 30 mg of curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, 0.3 ml diethylene glycol monoethyl ether and 0.1 ml polyethylene glycol 400.

13. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claim 10, wherein said composition has 30 mg of curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, 0.3 ml diethylene glycol monoethyl ether and 0.1 ml polyethylene glycol 600.

14. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claim 10, wherein said composition has 30 mg of curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, 0.3 ml diethylene glycol monoethyl ether, 0.1 ml polyethylene glycol 200, 0.1 ml polyethylene glycol 400 and 0.1ml polyethylene glycol 600.

15. A clear curcuminoid liquid composition for filling in transparent hard gelatin capsules comprising curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, caprylocaproyl Polyoxyl-8 glycérides, and low molecular weight polyethylene glycols.

16. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claim 15, wherein the low molecular weight polyethylene glycols are selected from polyethylene glycol 200 and polyethylene glycol 400.

17. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claim 16, wherein the caprylocaproyl Polyoxyl-8 glycérides, polyethylene glycol 200 and polyethylene glycol 400 are present in the volume to weight percentage ratio of at least 0.6, 0.4 and 0.6 respectively with respect to curcuminoids.

18. The clear curcuminoid liquid composition for filling in transparent hard gelatin capsules as claimed in claim 17, wherein the said composition has 50 mg weight of curcumin dry powder or turmeric extract powder containing at least 95% of curcuminoids, 0.3 ml caprylocaproyl Polyoxyl-8 glycérides, 0.2 ml polyethylene glycol 200, and 0.3 ml polyethylene glycol 400.

Dated this 28th day of November, 2019

Signature: To be digitally signed by-
Name: Mr. Parag M. More
OF INTELLECTUAL PLATFORM
Patent Agent for applicant
Patent Agent Regn. No. IN/PA-1688
On behalf of applicant