CUSTOMIZED TOPICAL COMPOSITION
Field of Invention- The present invention comprises of 1. Topical composition
2. Shade card wherein the topical composition for use by an individual is
customized on basis of complexion of individual user as determined by
matching of complexion and the color in the shade card, Without limitations
this form of customized topical composition is useful for treatment of various
skin disorders such as Acne Vulgaris, chloasma polymorphic light eruption
5seborrhic melanosis , post inflammatory pigmentation beside the therapeutic
field this can also be useful for users cosmetics
BACKGROUND OF THE INVENTION
Topical agents in the form of an applied cream or lotion are widely used in
dermatological therapy in treatment of various skin disorders such as Acne,
Photodermatitis, poly morphic light eruption ,Vitiligo , mask blemishes and
skin discoloration, reduce or prevent irritation, The ideal topical therapy,
would be specified by a team of experts for a particular individual with specific
needs, and for a specific environment or country whare it is being used. On
prescription the topical agent would then be formulated in a timely manner and
delivered to the individual. Unfortunately, logistics and cost have to date
limited the practicality of providing such a specific, optimized product to a
given user.
Currently, there are some approaches to provide topical agents that match a
particular, need , dermatologists prescribe these agents with particular
concentration of active agents those are available in the market however, the
l
SSB/15
need of an individual and also the area of skin to be treated varies e.g. the
facial skin may demand a lesser strength of concentration of active ingredient
as compared to skin over the back . They may be assembled in a retail store
from a set of ingredients by a knowledgeable clerk. However the time and cost
of preparing such medicament go up.
The main barrier to a general solution for the custom manufacture and
distribution of these topical agents is that the number of features in the product
are many, and the needs are quite varied. It is not commercially feasible to
manufacture and stock each formulation with the granularity that is optimum
' for a given need and of an individual and areas to be treated. What is needed,
then, are ways to provide useful compounds based on a determination of an
individual's specific needs using, for example formulations that are optimal for
that set of needs, further prepared ,formulated by a pharmacist 5medical
attendant or by the user him/her self by simple means of dilution dissolving or
mixing according to the color of the individual user as indicated by
correlating the shade card and the color of the individual user so that the topical
composition is made dermatologically acceptable meaning there is absence of
any undesirable effect on the skin on application of the composition.
The two factors those are to be considered to evaluate the need and necessity of
this invention are 1. Sensitive skin 2. Variation of skin color amongst general
population.
1. Sensitive Skin - Sensitive skin is a very common complaint amongst the
patients suffering from skin disorder the users of certain topical agents as well
L. H X d o ~ i £= ~ d KJ- JL o- JL. 3> - fc* d-
2
SSB/15
as users of cosmetics. Though there is lack of clear consensual in defining of
sensitive skin,a sensitive skin can be characterized by sensorial symptoms of
burning, feeling as stinging or tightness on application of various
medicaments or cosmetics . Most of the time there is absence of any clear
signs on the skin of the user but at times excess of drying which may present
as flaking can be found , However, this phenomenon of sensitive skin is not an
allergic reaction as sensitivity reaction process as we find and define under
dermalological consideration .
Some of this author have reported redness of skin associated with use of
topical therapeutic agent or cosmetics.
2. Variation in skin color -Variation of in color of the skin is wide amongst
the world population As we can find very in dark complexion as in Africans
and at one end in contrast to very light in celelies (Indian Journal of
Dermatology 2014, 59 (4) Pg. 339. This variation of color of the skin is not
only limited to race or country, as can be appreciated that in India which is an
Asian country geographically the population shows remarkable diversity
amongst its 2000 ethnic group at one end one can find very fair complexion
as in the northern most part i.e. Kashmir , Himanchal , Punjab in contrast to
very dark brown complexion in down south in Tamil Nadu and Kerala,
complexion also varies amongst the population belonging to same state ,further
complexion varies within the families because of hetrogenicity.
This variation of skin color is a major factor in precipitation of
photosenstievity as shown in by Fitzpatrick , and accordingly based on
photosensitivity Fitzpatrick has classified as Skin type I -VI.
SSB/15
Correlation of the above two factors- Interestingly it has been observed by
the inventors of this invention that there exists a correlation between the two
above discussed factors and it is the individuals who complain of sensitive
skin are those who have a lighter colored skin in other words it is lighter the
color of the skin greater is the complain of burning ,stinging, itching or
dryness on application of topical medicaments or cosmetics overcoming this
complain the dermatologists often advices to dilute the topical agent to make it
dermatologically acceptable, however, the amount or level of dilution is
difficult without a proper graduation or measurement because the degree of
sensitiveness varies from one to other , thus there is a need to quantify or read
the degree of sensitiveness which can provide a methodical and measured
amount of dilution and this can be attained through this invention wherein a
shade card is provided along with the composition/s to match with the color of
the skin of an user so that an optimal amount of dilution is attained without
losing the pharmaceutical or desired result. However a reverse is also observed
as in the use of Hydroquinone which is used in treatment of various
hyperpigmentry such as Chloasma . though it is widely used in the west the
use of hydroquinone produces severe erythematous reaction amongst the
vast majority of Indian Patients with darker complexion .
The above mentioned correlation is thus helpful in treatment of various
dermatological conditions ,without limitations this can be useful while treating
Acne, Chloasma, photosensitivity , photo dermatitis, pleomorphic light
eruption other conditions those may be included are seb.melanosis psoriasis,
SSB/15
lichen planus , though it is the face which is very commonly affected by
sensitiveness but other areas can also be involved.
Types of shade card with colors and shades-
Shade Cards - Shade cards have been used as an indicator to assess and/or
convince the user of the cosmetic improvement in color of the skin on using
the cosmetic agent over a period of time Shade card are also used in the field
of dentistry to assess whitening of the teeth on using the tooth paste mostly it
is the cosmetic industry shade cards have been used as in products by 1 c
OREAL or UNILEVERS Fair and Lovely in the field of dermatological
practice shade card has been used in assessing improvement in blemishes , it
has also been used in assessment of changes in color in cases of melanoma.
There are various types of shade cards such as Taylor 's hyperpigmented scale,
another popular skin color chart is the Felix von Lusschan skin color chart
which was used in assessing the complexion of an individual /other forms of
color shade cards can be used as an indicator . The color chart can be as made
and used based on Fitzpatrick typing of skin.
PRIOR ART
Earlier before the era of industrialization the art of dispensing was in vogue and
the physician had the opportunity of prescribing medicines according to
individual needs, the pharmacist were there to serve the prescription
accordingly ,however with passage of time and industrialization the practice of
dispensing has gone in oblivion, now the physician has to depend on what is
available in the market, the individual need is not possible to catered and one
5
SSB/15
has to prescribe what is available. The liberty of individualized and customized
in terms of activate and inactivate ingredients.
This draw back can be over corned by this simple means of dilution dissolve
and mixing by the individual or a pharmacist. The main barrier to a general
solution for the custom manufacturing and distribution of these topical agents
is that the number of features in the product is many, and the needs are quite
varied. It is not commercially feasible to manufacture and stock each formation
to meet this challenges Howell et al in there disclosure US Publication No
9122919. describe of system and methods for specifying topical customized
agents in there work there is use of mobile phone, a table, a digital camera, a
webcam, smart phone etc. These are not as a very popular amongst the Indian
masses and there is a need for a simpler method of matching the colour based
on shade card matching. Mridula Kini, et.al., in the Patent publication no.
WO2010100032 Al describes of a shade with indicator in the field of
cosmetics to assess the improvement in complexion on use of cosmetic
EMBODIMENTSThe
present invention comprises of 1. Topical composition 2. Shade card
wherein the topical composition for use by an individual is customized on
basis of complexion of individual user as determined by matching of
complexion and the color in the shade card, Without limitations this form of
customized topical composition is useful for treatment of various skin
disorders such as Acne Vulgaris, chloasma polymorphic light eruption
,seborrhic melanosis , post inflammatory pigmentation ,
6
SSB/15
Further Topical composition can be helpful in topical therapy prepared
^formulated by a pharmacist ,medical attendant or by the user him/her self by
simple means of dilution dissolving or mixing according to the color of the
individual user which is indicated by correlating the shade card so that the
topical composition thus formulated is made dermatologically acceptable, the
composition can be provided in separate packaging or can be packaged along
with. In one embodiment a shade card is provided along with a topical
medicament along with a shade card.
In second embodiment a medicament containing active and inactive ingredient
along with the shade card is provided wherein the medicament can be diluted
with a water or any solvent system according to the color of the skin which
matches with the color shade in the shade card.
In third embodiment a shade card is provided along with two or more topical
compositions containing active ingredients those can be mixed and make a
pharmaceutically and dermatologically acceptable according to the color
matched with the shade card.
In fourth embodiment a topical composition is prepared by mixing of two or
more topical agents which on mixing yields a colored composition which
matches with the color of the individual user as indicated by the colored shade
card.
In fifth embodiment a shade card is provided along with topical composition/s
to form a kit wherein the shade card is based on Fitzpatrick skin pattern with
grading as described with grading of I- VI according to the race.
In sixth embodiment topical agents are provided along with a shade card
wherein the topical composition is of different colors but on mixing gives a
color which matched with the color of the patient according to the shade card.
7
SSB/15
In seventh embodiment a kit is provided wherein the composition or more are
provided which is mixed and matched according to the ph of the skin which is
indicated by the hade card.
Examples -
1. Salicylic Acid - 2.5 gm
Ethyl Alcohol - 65 ml
Aqua Distil - q.s.
Packaged along with aShade card depicting Felix von Luschan skin color chart
Felix von Luschan scale
0-6 Very light or white
7-13 Light or light-skin
14-20 Light intermediate,
21-27 Dark intermediate
28-34 Dark or Dark brown
35-36 Very dark or Black
2. 8 Methoxypsoralen - 0.75 gm
Acetone - 15 ml
Propylene Glycol - 15 cc
Aqua - q.s.
Packaged along with a Shade card based on Fitzpatrick Skin Type I-VI
Fitzpatrick type
I Very light or white
II Light or light-skin
III Light intermediate,
IV Dark intermediate
V Dark or Dark brown
,„ Very dark or Black
Accompanying dilution component - Acetone 50 cc
It will be appreciated that the examples hereinabove gives a relatively simple
indication of usage of this invention many formulations can be prepared and
can be therapeutically be used based on colored shade card matching .
8
SSB/15
All documents referred herein including all patents, patent application and
printed publication are hereby incorporated by reference in their entirety in this
disclosure. It should be understood that the specific forms of the invention
herein described are intended to be representative only and certain changes
may be made therein without departing from the teaching of the disclosure.
Although the invention has been described with reference to specific
embodiments, it will be appreciated by those skilled in the art that the invention
may be embodied in many other forms without departing from the true spirit of
invention.
REFERENCES
1. Sensitive Skin, Basis Science for Cosmetic Dermatology, First Edition,
Jaypee Medical Incorporation, Chapter 9, P-128 to 136.
2. Arucha Treesirichod et.al. Correlation Between skin color evaluation by
skin color scale chart and narrowband reflectance spectrophotometer,
Indian Journal of Dermatology, 2014; 59 (4) Page- 339-342.
3. Hourblin V, et.al., Skin Complexion and pigmentory disorders in facial
skin of 1204 women in 4 Indian Cities. Indian Journal of Dermatology,
Venereol Leprol 2014;80:395-401.
4. Wikipedia.org, Sen Francisco Wikipedia foundation Incorporation C
2003, available from https://en.wikipedia.org/wiki/Von_ Luschan's_
chromatic_scale Page updated on 12 November 2016 website visited on
26 December 2016
5. Taylor S. et.al. Noninvasive techniques for the evaluation of skin color.
J Am Acad Dermatology 2006; 54:S282-290.
6. Braun Falcos Dermatology Vol. 1 Third Ed.

I/We claim
1) A topical Pharmaceutical composition comprising of 1. A skin color
shade card 2. A topical medicament for treatment of various
dermatological condition wherein the topical agent is prepared in
customized basis for use by the individual in need based on matching of
complexion of the individual user and shade card color.
2) The topical component of Claim 1 is in a lotion, solution , cream or
ointment dosage form, preferably in a solution or a lotion form
3) The composition of Claim 1 is for use in treatment of Acne, Chloasma,
Photodermatitis, Hyperpigmentation, Polymorphic Light eruption
, Vitiligo.
4) The topical medicament component of claim 1 comprises of one or more
of the active ingredients including but not limited to Salysalic Acid,
Benzoic Acid, Benzoyl per oxide, Retinoic Acid, Kojic acid, Nicitonic
Acid, Resorcinol, Recorcinol Mono acetate, Hydroquinone, Psoralen ,
trimethyl psoralen 8 methoxy psoralen.
5) The topical medicament component of Claim 1 comprises of one or
more of the ingredients derived from plants and herbs such as Aloe vera
,angelica, Beet root, bengal rose , blackberry, bloodroot, blue flag,
bogbean, boldo, boneset, broom, ,buchu, burdock, bumet calendula
coltsfoot, dandelion ,Hibiscus Henna, cereus, chamomile, german
chamomile, roman chamomile, cinnamon, cohosh, blue, cola, corn silk,
SSB/15
cowslip, damiana, devil's claw, drosera, elder, elecampane, euphorbia,
eyebright, figwort, frangula, fiicus, fumitory, garlic, golden seal, gravel
root, ground ivy, guaiacum, hawthorn, holy thistle, hops, horehound
blackberry, lime flower, liquorice, lobelia, mate, meadowsweet,
mistletoe, motherwort, myrrh, nettle, parsley, parsley piert,
passionflower, pennyroyal, pilewort, plantain, pleurisy root, pokeroot,
poplar, Pulsatilla, queen's delight, raspberry, red clover, rosemary, a
scullcap, squill, St. John's wort, stone root, tansy, Turmeric.
6) The colors in Shade Card component of Claim 1 is Felix von Luschan
skin color chart, Taylor hyperpigmented scale or a print of color shades
prepared by combination of colored printable inks.
7) The colored shade card of claim one is printed in a card board , plastic,
or printed on the label of the packaging
8) The composition of Claim 1 is provided in form of a kit where in beside
the shade card and topical medicament a separate packaging is provided
containing, distilled aqua or a solvent.
9) The composition of Claim 4 comprises, of photo chemotherapy agent
such as Spiraled, Trimethl, Psoralen 8 methoxy psoralen and the shade
cards is based on Fitzpatrick pattern of skin colour.