The present invention relates to a device and a method for damaging a cut portion of a medical glass product, and more specifically, an ultra-cutting portion of a medical glass product such as an ampoule using glass as a material or a glass tube for medical equipment. The present invention relates to a damaging processing device and a method capable of performing damage processing with a fast laser (Ultrafast Laser) to minimize the generation of glass fragments.
Background technology
[0002]
The present invention relates to a method for damaging a cut portion of a medical glass product, such as a glass ampoule for storing an injection solution or a nutritional supplement, or a medical glass tube.
[0003]
Medical glass products such as glass ampoules that store injections or nutritional supplements are manufactured in a form that allows the contents of injections and nutritional supplements to enter the human body. It is imperative that the tubes be manufactured to be completely sterile / dust-free in the process of breaking to separate them. Therefore, in the manufacturing process, meticulous consideration and considerable care are required.
[0004]
However, in the conventional manufacturing process of medical glass products, foreign substances such as glass fragments may always enter the ampoule. For example, an OPC ampoule used as a container for injections or nutritional supplements is an ampoule designed to minimize the generation of glass shards, but even if it is used normally, the user puts effort into it by hand. Fine glass fragments will be generated when cutting.
[0005]
For example, referring to FIG. 8 showing a prior art injectable or nutritional supplement ampoule 20, the conventional or nutritional supplement ampoule 20 has a cutting direction indicator 23, a cutting assist notch 22 and a bottleneck. 24 is included.
[0006]
In this case, in the conventional ampoule 20 for injection or nutritional supplement, a cutting assist notch 22 is formed at the cutting portion of the neck (bottleneck portion 24) of the ampoule by a diamond blade rotating at a high speed. Then, in order to facilitate cutting, a bottleneck portion whose diameter is smaller than that of the periphery is provided, and pressure is applied to the portion displayed on the cutting direction display unit 23 to allow the user to manually cut the ampoule. do. Then, the notch 22 for cutting assistance is folded and opened as a starting point, and the injection solution or the nutritional supplement inside the ampoule can be used there.
[0007]
9 (a) and 9 (b) are photographs taken at high speed of the cut portion of the glass ampoule when the user manually opens the glass ampoule in which the notch 22 for cutting assistance is formed by the conventional technique. In FIG. 9A, it can be seen that the glass dust is scattered even though the glass ampoule is normally opened. Further, referring to FIG. 9B, it can be seen that large glass fragments are generated.
[0008]
At this time, when the user (for example, a nurse) cuts the cutting site of the ampoule for injection or drinking with the injection solution or the nutritional supplement contained in the OPC ampoule, the fine glass generated at the time of forming the cutting assist notch. Powder can get inside the ampoule.
[0009]
In order to solve the problem that fine glass dust may be generated when cutting auxiliary notches are processed through a diamond blade, a method of creating fine gaps with a laser (Japanese Patent Laid-Open No. 11-71124) was also devised. Have been done. However, since such a method also creates a groove in a part of the area from the glass surface of the ampoule, there is a disadvantage that large glass fragments may be generated if the user applies a force in the wrong direction. ..
[0010]
Therefore, when not used correctly (for example, when the user applies a force in a direction different from the direction displayed on the cutting direction display unit 23), the generation of glass fragments can be significantly increased. That is, the OPC ampoule 20 is manufactured so that when the glass is cut, the glass is given directionality so that debris is not generated. , More glass shards will be generated.
[0011]
Since such glass fragments and glass powder can cause great damage to the human body if they enter the human body, in particular, the user of the injection solution does not use all the injection solution, but instead uses the injection solution of the part where the glass powder sinks. It will be used except.
[0012]
Therefore, in order to prevent such wasteful use of medical drugs or nutritional supplements, and to remove glass fragments and dust that are harmful to the human body, the possibility of foreign matter flowing into the ampoule is eliminated, and it is completely dust-free for medical use. There is an urgent need for a method for manufacturing medical glass products that can provide a glass product process.
Prior art literature
Patent documents
[0013]
Patent Document 1: Japanese Patent Application Laid-Open No. 11-71124
Outline of the invention
[0014]
An object to be solved by the present invention is to provide a completely dust-free medical glass product damaging process by removing the source of foreign matter flowing into an ampoule during the manufacturing process of a medical glass product. ..
[0015]
Therefore, according to the present invention, there is provided a method for processing a medical glass product that minimizes the generation of particles during cutting.
[0016]
On the other hand, another object of the present invention is that the ampoule is produced as described above, and particles are generated regardless of the direction in which the ampoule for injection or nutritional supplement is cut without indicating the cutting direction on the ampoule. It is to provide a method for producing an ampoule for injection or a nutritional supplement with almost no ampoule and an ampoule for injection.
[0017]
Further, another object of the present invention is that it is not necessary to bother to prepare a bottleneck portion when manufacturing an ampoule for injection or a nutritional supplement, and the process time and defects required for manufacturing the bottleneck are significantly reduced. It is to provide a method for producing an ampoule for injection or a nutritional supplement which can be made to be used, and an ampoule for injection or a nutritional supplement.
[0018]
In order to solve the above-mentioned problems, the cutting site damaging device for the medical glass product according to the embodiment of the present disclosure is a laser light source that bursts an ultrafast laser beam; the ultrafast laser beam is used. Beam profile forming part that has multiple focal distances and is molded to have an elongated form of profile; the profile of the molded ultrafast laser beam is formed inside the glass of the medical glassware. A beam irradiation unit that is irradiated so as to form an inside damage formed by an internal defect due to bulk deformation inside the glass of the medical glass product; and the medical glass product. A rotating portion that rotates at a predetermined rotation speed can be included.
[0019]
At this time, the cutting site damaging device of the medical glass product sets the predetermined rotation speed and the burst speed of the laser beam so that a plurality of the inside damages are formed at the cut portion of the medical glass product. It can further include a control unit to control.
[0020]
Further, the inside damage may be formed in the thickness direction of the glass along the circumference of the medical glass product.
[0021]
Further, the medical glass product may include any one of an ampoule for injection or a nutritional supplement, a blood collection tube, a syringe, a cartridge, a glass medicine bottle, and a glass tube for a medical device. ..
[0022]
Therefore, according to the present invention, it is possible to provide a method for processing a medical glass product in which the generation of particles is minimized at the time of cutting.
[0023]
On the other hand, in the case of the injection ampoule according to the embodiment of the present invention, cutting errors can be reduced when the ampoule is used. That is, even if the cutting direction is not displayed on the ampoule, particles are hardly generated regardless of the cutting direction, so that cutting errors during use of the ampoule can be significantly reduced.
[0024]
Further, when manufacturing the ampoule for injection, it is not necessary to add a process to the bottleneck portion, so that the process time and defects required for manufacturing the bottleneck are significantly reduced.
[0025]
The effects according to the present invention are not limited by the contents exemplified above, and various effects are further included in the present specification.
A brief description of the drawing
[0026]
FIG. 1 is a block diagram of a cutting site damaging device for a medical glass product according to an embodiment of the present invention.
FIG. 2 is a diagram (No. 1) for explaining a laser beam having a plurality of focal lengths due to self-diffraction of an axicon lens according to an embodiment of the present invention.
FIG. 3 is a diagram (No. 2) for explaining a laser beam having a plurality of focal lengths due to self-diffraction of an axicon lens according to an embodiment of the present invention.
FIG. 4 is a diagram (No. 3) for explaining a laser beam having a plurality of focal lengths due to self-diffraction of an axicon lens according to an embodiment of the present invention.
FIG. 5 is a diagram for explaining the thickness direction of the glass of the ampoule of the medical glass product according to the embodiment of the present invention.
FIG. 6 is a diagram for explaining a medical glass product manufactured according to an embodiment of the present invention.
FIG. 7 is a diagram for explaining a medical glass product manufactured according to an embodiment of the present invention.
[Fig. 8] Fig. 8 is a diagram showing an ampoule for injection or a nutritional supplement according to a conventional technique.
[Fig. 9a] This is a high-speed photograph taken at the time of opening an ampoule manufactured by a conventional technique.
[Fig. 9b] This is a high-speed photograph of an ampoule manufactured by conventional technology when it is open.
Embodiment for carrying out the invention
[0027]
The following content merely exemplifies the principle of the invention. Therefore, one of ordinary skill in the art can embody the principles of the invention and invent various devices within the concept and scope of the invention, which are not expressly described or illustrated herein. Also, all conditional terms and examples listed herein are, in principle, expressly intended only for the purpose of understanding the concepts of the invention and are thus specifically listed. It should be understood that there are no restrictions on the examples and conditions.
[0028]
Further, in the following description, mathematical expressions such as the first, second, etc. are for explaining objects that are equivalent to each other and independent of each other, and the order is main / sub or main. It should be understood that there is no meaning of (master) / slave.
[0029]
The above-mentioned objectives, features and advantages will be further clarified through the following detailed description in connection with the accompanying drawings, thereby facilitating the technical idea of ​​the invention by those with ordinary knowledge in the field of technology to which the invention belongs. Will be able to be carried out.
[0030]
Each feature of the various embodiments of the invention can be partially or wholly coupled to or combined with each other and can be technically varied and interlocked and driven, as will be fully understood by those skilled in the art. The examples can be implemented independently of each other and can be implemented together in a related relationship.
[0031]
Hereinafter, various embodiments of the present invention will be described in detail with reference to the accompanying drawings.
[0032]
FIG. 1 is a block diagram of a cutting site damaging device 1000 for a medical glass product according to an embodiment of the present invention. According to FIG. 1, the cutting site damaging device for glass products includes a control unit 100, a laser light source 200, an energy control module 300, a beam expander 400, a beam profile forming unit 500, a beam irradiation unit 600, and a rotation unit. A unit 700 and a distance adjusting unit 800 can be included. Here, the medical glass product is a cut surface processed with glass including a tube-shaped part such as an ampoule for injection or a nutritional supplement, a blood collection tube, a syringe, a cartridge, and a glass medicine bottle. It means a medical glass product that has no glass fragments or glass dust inside.
[0033]
As a material for glass products, soda lime, quartz, borosilicate glass and the like are used. In particular, in the case of a medical glass container, borosilicate glass is preferable.
[0034]
The control unit 100 can control the energy of the laser beam 150, the distance between the workpiece (medical glass product) 10 and the beam irradiation unit 500, and the rotation speed of the rotating unit 700. Further, the magnification can be adjusted through the control for adjusting the distance between the first condenser lens 630 and the second condenser lens 650. Further, the control unit 100 can control the number of bursts of the laser beam 150 according to the rotation speed of the rotation unit 700.
[0035]
The laser light source 200 is a light source that generates and irradiates an ultrafast laser beam 150.
[0036]
Further, the energy control module 300 and the beam expansion unit 400 are configured to adjust the energy amount and magnitude of the laser beam reaching the workpiece 10. In this case, an optical mechanism such as a plurality of mirrors 410 can be further provided so that the laser beam generated by the laser light source reaches the beam profile forming unit 500 and the beam irradiating unit 600.
[0037]
The beam profile forming unit 500 is configured to form a profile of a laser beam that has a plurality of focal lengths due to self-diffraction of the axicon lens, and an axicon lens is preferably used. ..
[0038]
As shown in FIG. 2, a laser beam having a plurality of focal lengths due to self-diffraction of an axicon lens is generally a laser having a conical shape, for example, a laser passing through the axicon lens 500 when passing through the lens. Formed through beam interference. At this time, the wavefront of the laser beam is formed by the diffraction of the Gaussian beam passing through the axicon lens. The fringes are long and consist of a central core with a micro unit diameter and several rings with relatively low intensity strength surrounding these cores. That is, according to the embodiment of the present invention, the beam profile forming unit 500 is molded so that the ultrafast laser beam has a plurality of focal lengths and has a profile having a high aspect ratio in an elongated form. ..
[0039]
In this case, the laser beam is partially absorbed while passing through the glass of the workpiece 10, and transfers energy to the constituent molecules of the glass. At this time, the absorbed energy density is high and the laser beam is instantaneously absorbed. Plasma is formed inside the glass of the workpiece 10. Referring to FIG. 3, the above-mentioned plasma forms an internal defect due to bulk deformation with a high aspect ratio inside the glass of the workpiece 10. The internal defect formed by the laser beam in this way is referred to as damage in the present specification, and the process of forming the damage is referred to as the damage process, and the structure in which the damage is formed assists the cutting of the medical glass product. Is referred to as inside damage (Inside Damage, see FIGS. 3 and 6) 15.
[0040]
In the embodiment of the present invention, the step of continuously forming damage by the laser beam is used to form a structure that replaces the cutting assist notch using the diamond blade of the conventional technique. Further, a method and an apparatus for cutting a medical glass product by forming inside damage are also included in the scope of the present invention.
[0041]
In this case, the central core radius (r) of the laser beam that has a plurality of focal lengths due to the self-diffraction of the axicon lens can be indicated by the following equation (1) (the portion shown in FIG. 2 is the diameter). 2r).
[0042]
[Number 1]

[0043]
Here, θ is the angle between the two diffracted wave vectors formed by the axicon lens (see FIG. 2). Such an angle is determined by the axicon parameter (eg, the axicon parameter includes the angle of the apex of the axicon lens and the optical index of refraction). Further, from a geometrical point of view, the length (L) of the laser beam that has a plurality of focal lengths due to self-diffraction of the axicon lens, which is called depth of focus, can be calculated by the following equation 2.
[0044]
[Number 2]

[0045]
Here, w is the diameter of the laser beam 150 incident on the axicon lens.
[0046]
In this case, the morphology of the laser beam, which results from the self-diffraction of the axicon lens to have multiple focal lengths, is designed to create elongated, uniform inside damage along the thickness of the glass. .. Here, "elongated" means that the length (L) of the inside damage processed into the glass of the workpiece 10 is much larger than the radius (R) of the inside damage, and the length (L) of the inside damage is This means that the inside damage radius (R) is 10 times or more.
[0047]
The beam irradiation unit 600 includes optical mechanisms 630 and 650 that allow the laser beam deformed by the beam profile deformation unit 500 to have an elongated profile to be incident on the glass portion of the workpiece 10, and whether or not the laser beam is accurately incident. A identifiable coaxial CCD camera 610 and an Episcopic illumination 620 can be included. At this time, beam splitters 640 and 660 can be included to align the coaxial CCD camera 610 and the episcopic illumination 620 with the laser beam 160.
[0048]
In this case, the beam irradiation unit 600 described above includes the first condensing lens 630, the second condensing lens 650, and the magnification adjusting device (see FIG. 4) 635 locally inside the glass material of the workpiece 10. The laser beam can be controlled to form a concentrated energy. Therefore, the deformed laser beam 160 is imaged through the first condensing lens 630 and the second condensing lens 650 to cause bulk deformation at a reduced rate.
[0049]
The wavelength of the laser beam used in this embodiment is a wavelength in the region of 1030 to 1070 nm, and the focal length is the self of the axicon lens inside the glass product in the thickness direction of the glass from the glass surface of the workpiece. Diffraction allowed the formation of a starting point for a laser beam that would have multiple focal lengths.
[0050]
On the other hand, the rotating portion 700 is configured to rotate the workpiece 10 in order to form the inside damage 15 in the thickness direction of the glass along the circumference of the workpiece 10. In this case, the thickness direction of the glass means the direction perpendicular to the glass surface of the workpiece 10 (see the direction A in FIG. 5). In this case, the control unit 100 determines the interval between the inside damages depending on the rotation speed and the burst time point of the laser beam. Further, the control unit 100 can control the number of bursts (Burst Numbers) to control the energy of the laser beam provided in the thickness direction of the glass. The number of bursts means the number of pulses contained in one burst.
[0051]
On the other hand, the distance adjusting unit 800 adjusts the distance between the workpiece 10 and the beam irradiation unit 600, and the laser beam having a plurality of focal lengths due to the self-diffraction of the axicon lens is accurately the workpiece. Allows imaging inside 10 glasses.
[0052]
6 (a) to 6 (c) are views for explaining the inside damage formed in the circumferential direction while rotating the workpiece 10 by the rotating portion 700.
[0053]
6 (a) is a diagram showing a part of the workpiece 10, and FIG. 6 (b) is a diagram showing a cross section of the BB' portion of FIG. 6 (a). (C) is a photograph of the inside damage 15 of FIG. 6 (b) actually embodied.
[0054]
As shown in FIGS. 6 (b) and 6 (c), the workpiece 10 is provided with a laser beam that has a plurality of focal lengths due to the self-diffraction of the axicon lens formed by the beam profile forming unit 500. For example, it can be seen that the inside damage 15 is formed in the thickness direction of the glass along the circumferential surface of the cut portion of the ampoule for injection.
[0055]
7 (a) and 7 (b) are diagrams for explaining the embodiment and the effect according to the embodiment of the present invention.
[0056]
In FIGS. 7 (a) and 7 (b), inside damage having a diameter of 2 to 4 μm was formed while rotating an injection ampoule as the workpiece 10. The length (L) of the laser beam that has a plurality of focal lengths due to the self-diffraction of the axicon lens is processed to be approximately the glass thickness of the glass. In this case, the circumference of the ampoule is about 4 mm, the laser used has a wavelength of 1030 nm to 1070 nm, and the pulse energy is embodied as 80 uJ or more. Then, the ultrafast laser beam was burst at a speed of 1000 Khz or more.
[0057]
When processed under the above-mentioned conditions, as shown in FIGS. 7 (a) and 7 (b), the cut surface of the injection ampoule is reproduced in a form similar to the polished surface (2 to 3 μm) and has a cross section. No modification changes or cracks occurred.
[0058]
Therefore, according to the present invention, there is provided a completely dust-free medical glass product process by removing the source of foreign matter flowing into the ampoule during the manufacturing process of the medical glass product.
[0059]
Further, according to the present invention, there is provided a method for processing a medical glass product in which the generation of particles is minimized at the time of cutting.
[0060]
On the other hand, in the case of the injection ampoule according to the embodiment of the present invention, cutting errors can be reduced when the ampoule is used. That is, even if the cutting direction is not displayed on the ampoule, particles are hardly generated regardless of the cutting direction, so that cutting errors during use of the ampoule can be significantly reduced.
[0061]
Further, when manufacturing the ampoule for injection, it is not necessary to add a process to the bottleneck portion, so that the process time and defects required for manufacturing the bottleneck are significantly reduced.
[0062]
Although the embodiments of the present invention have been described in more detail with reference to the accompanying drawings, the present invention is not necessarily limited to such examples and is within the scope of the technical idea of ​​the present invention. It can be modified in various ways within. Therefore, the examples disclosed in the present invention are not intended to limit the technical idea of ​​the present invention, but are intended to explain, and such examples limit the scope of the technical idea of ​​the present invention. It's not something. Therefore, it should be understood that the examples described above are exemplary in all respects and are not limiting. The scope of protection of the present invention should be construed according to the following claims, and all technical ideas within the equivalent scope should be construed as being included in the scope of rights of the present invention.
Description of the sign
[0063]
100 Control unit
200 Laser light source
300 energy control module
400 Beam extension
500 Beam profile forming part
600 beam irradiation part
630, 650 1st and 2nd condenser lenses
700 rotating part
800 distance adjustment unit
The scope of the claims
[Claim 1]
A laser light source that bursts an ultrafast laser beam;
A beam profile forming section that allows the ultrafast laser beam to have multiple focal lengths and is shaped to have an elongated morphological profile;
The profile of the molded ultrafast laser beam is irradiated so as to be formed inside the glass of the medical glass product, and is formed inside the glass of the medical glass product by internal defects due to bulk deformation. Beam irradiation part that allows inside damage to be formed;
A rotating portion that rotates the medical glass product at a predetermined rotation speed so that a plurality of the inside damages are formed along the circumference of the medical glass product.
Cutting site damage device for medical glass products.
[Claim 2]
The predetermined rotation speed and the burst number of the laser beam (Burst Numbers) so that a plurality of the inside damages are formed at the cut portion of the medical glass product. ) Is further included,
The cutting site damaging device for medical glass products according to claim 1.
[Claim 3]
The inside damage is formed in the thickness direction of the glass along the circumference of the medical glass product.
The cutting site damaging device for medical glass products according to claim 1.
[Claim 4]
The medical glass product is characterized by being any one of an ampoule for injection or a nutritional supplement, a blood collection tube, a syringe, a cartridge, a glass medicine bottle, and a glass tube for a medical device. ,
The cutting site damaging device for medical glass products according to claim 1.
[Claim 5]
The step of bursting an ultrafast laser beam;
The step of forming the ultrafast laser beam so that it has multiple focal lengths and has an elongated morphological profile;
The profile of the molded ultrafast laser beam is irradiated so as to be formed inside the glass of the medical glass product, and is formed inside the glass of the medical glass product by internal defects due to bulk deformation. Steps to allow inside damage to form; and
Including the step of rotating the medical glass product at a predetermined rotation speed.
How to damage the cut part of medical glass products.
[Claim 6]
Further including a step of controlling the predetermined rotation speed and the burst number (Burst Numbers) of the laser beam so that a plurality of the inside damages are formed at the cut portion of the medical glass product.
The method for damaging a cut portion of a medical glass product according to claim 5.
[Claim 7]
The inside damage is formed in the thickness direction of the glass along the circumference of the medical glass product.
The method for damaging a cut portion of a medical glass product according to claim 5.
[Claim 8]
The medical glass product is characterized by being any one of an ampoule for injection or a nutritional supplement, a blood collection tube, a syringe, a cartridge, a glass medicine bottle, and a glass tube for a medical device. ,
The method for damaging a cut portion of a medical glass product according to claim 5.