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"Determining The Sensitivity Of A Cell To A Drug"
Abstract: The present invention provides an in vitro method for determining the resistance or sensitivity of a cell line or patient sample to a deoxyribonucleoside kinase-dependent drug, wherein the method comprises the steps of: (i) treating a patient sample or cell line, or a portion thereof, with a deoxyribonucleoside kinase-dependent drug; (ii) lysing the cells of the patient sample or cell line from step (i); (iii) optionally, mixing a portion of the cell lysate from step (ii) with a biolumine scent reporter bacteria incorporating a gene coding for deoxyribonucleoside kinase; (iv) mixing a portion of the cell lysate from (ii) with a bioluminescent reporter bacteria incorporating a gene coding for a deoxyribonucleoside kinase and a deoxyribonucleoside kinase transcription promoter; (v) mixing a portion of the cell lysate from step (ii) with a bioluminescent reporter bacteria incorporating a gene coding for a deoxyribonucleoside kinase, a deoxyribonucleoside kinase transcription promoter and a dephosphorylating agent; and (vi) measuring the bioluminescence of each of the mixtures from steps (iii) to (v), wherein the comparative levels of bioluminescence of each of the mixtures provides a measure of the resistance or sensitivity to the drug.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
24 January 2011
Publication Number
05/2012
Publication Type
INA
Invention Field
MICRO BIOLOGY
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2018-07-30
Renewal Date
Applicants
RANDOX LABORATORIES LIMITED
ARDMORE, DIAMOND ROAD, CRUMLIN, COUNTY ANTRIM BT29 4QY, UNITED KINGDOM
UNIVERSITY OF THE WEST OF ENGLAND
BRISTOL FRENCHAY CAMPUS, COLDHARBOUR LANE, BRISTOL BS16 1QY, UNITED KINGDOM
Inventors
1. SALISBURY, VYVYAN, CLARE
UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL FRENCHAY CAMPUS, COLDHARBOUR LANE, BRISTOL BS16 1QY, UNITED KINGDOM
2. ALLOUSH, HABIB, MAHMOUD
UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL FRENCHAY CAMPUS, COLDHARBOUR LANE, BRISTOL BS16 1QY, UNITED KINGDOM
3. SMITH, MARGARET, ANN
UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL FRENCHAY CAMPUS, COLDHARBOUR LANE, BRISTOL BS16 1QY, UNITED KINGDOM
4. INNOCENZI, PAUL, JOHN
RANDOX LABORATORIES LIMITED ARDMORE, DIAMOND ROAD, CRUMLIN, COUNTY ANTRIM BT29 4QY, UNITED KINGDOM
5. RUDDOCK, MARK, WILLIAM
RANDOX LABORATORIES LIMITED ARDMORE, DIAMOND ROAD, CRUMLIN, COUNTY ANTRIM BT29 4QY, UNITED KINGDOM
6. MARTIN, ASHLEY DIANE
RANDOX LABORATORIES LIMITED ARDMORE, DIAMOND ROAD, CRUMLIN, COUNTY ANTRIM BT29 4QY, UNITED KINGDOM
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
| 15 | NILANJANA MUKHERJEE | 2018-02-22 |
| 77(1)(f) | NILANJANA MUKHERJEE | 2018-07-30 |
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 543-DELNP-2011-Correspondence Others-(01-04-2011).pdf | 2011-04-01 |
| 2 | 543-delnp-2011-Form-18-(07-04-2011).pdf | 2011-04-07 |
| 3 | 543-delnp-2011-Correspondence-Others-(07-04-2011).pdf | 2011-04-07 |
| 4 | 543-delnp-2011-Form-3-(13-07-2011).pdf | 2011-07-13 |
| 5 | 543-delnp-2011-Correspondence-Others-(13-07-2011).pdf | 2011-07-13 |
| 6 | 543-Delnp-2011-GPA-(20-07-2011).pdf | 2011-07-20 |
| 7 | 543-Delnp-2011-Form-1-(20-07-2011).pdf | 2011-07-20 |
| 8 | 543-Delnp-2011-Correspodence Others-(20-07-2011).pdf | 2011-07-20 |
| 9 | 543-DELNP-2011-GPA-(21-07-2011).pdf | 2011-07-21 |
| 10 | 543-DELNP-2011-Form-1-(21-07-2011).pdf | 2011-07-21 |
| 11 | 543-DELNP-2011-Correspondence-Others-(21-07-2011).pdf | 2011-07-21 |
| 12 | Abstract.jpg | 2011-11-25 |
| 13 | 543-delnp-2011-Form-5.pdf | 2011-11-25 |
| 14 | 543-delnp-2011-Form-3.pdf | 2011-11-25 |
| 15 | 543-delnp-2011-Form-2.pdf | 2011-11-25 |
| 16 | 543-delnp-2011-Form-1.pdf | 2011-11-25 |
| 17 | 543-delnp-2011-Drawings.pdf | 2011-11-25 |
| 18 | 543-delnp-2011-Description (Complete).pdf | 2011-11-25 |
| 19 | 543-delnp-2011-Correspondence-others.pdf | 2011-11-25 |
| 20 | 543-delnp-2011-Claims.pdf | 2011-11-25 |
| 21 | 543-delnp-2011-Abstract.pdf | 2011-11-25 |
| 22 | 543-delnp-2011-Others-(08-05-2015).pdf | 2015-05-08 |
| 23 | 543-delnp-2011-Form-3-(08-05-2015).pdf | 2015-05-08 |
| 24 | 543-delnp-2011-Correspondence Others-(08-05-2015).pdf | 2015-05-08 |
| 25 | 543-delnp-2011-Form-3-(06-08-2015).pdf | 2015-08-06 |
| 26 | 543-delnp-2011-Correspodence Others-(06-08-2015).pdf | 2015-08-06 |
| 27 | Other Document [18-08-2015(online)].pdf | 2015-08-18 |
| 28 | Marked Copy [18-08-2015(online)].pdf | 2015-08-18 |
| 29 | Form 13 [18-08-2015(online)].pdf | 2015-08-18 |
| 30 | Description(Complete) [18-08-2015(online)].pdf | 2015-08-18 |
| 31 | 543-delnp-2011-Others-(19-08-2015).pdf | 2015-08-19 |
| 32 | 543-delnp-2011-Marked Form-5-(19-08-2015).pdf | 2015-08-19 |
| 33 | 543-delnp-2011-Marked Form-2-(19-08-2015).pdf | 2015-08-19 |
| 34 | 543-delnp-2011-Marked Form-1-(19-08-2015).pdf | 2015-08-19 |
| 35 | 543-delnp-2011-Form-5-(19-08-2015).pdf | 2015-08-19 |
| 36 | 543-delnp-2011-Form-2-(19-08-2015).pdf | 2015-08-19 |
| 37 | 543-delnp-2011-Form-13copy-(19-08-2015).pdf | 2015-08-19 |
| 38 | 543-delnp-2011-Correspondence Others-(19-08-2015).pdf | 2015-08-19 |
| 39 | 543-delnp-2011-Marked Claims-(25-08-2015).pdf | 2015-08-25 |
| 40 | 543-delnp-2011-GPA-(25-08-2015).pdf | 2015-08-25 |
| 41 | 543-delnp-2011-Form-2-(25-08-2015).pdf | 2015-08-25 |
| 42 | 543-delnp-2011-Form-1-(25-08-2015).pdf | 2015-08-25 |
| 43 | 543-delnp-2011-Drawings-(25-08-2015).pdf | 2015-08-25 |
| 44 | 543-delnp-2011-Description (Complete)-(25-08-2015).pdf | 2015-08-25 |
| 45 | 543-delnp-2011-Correspondence Other-(25-08-2015).pdf | 2015-08-25 |
| 46 | 543-delnp-2011-Claims-(25-08-2015).pdf | 2015-08-25 |
| 47 | 543-delnp-2011-Abstract-(25-08-2015).pdf | 2015-08-25 |
| 48 | 543-delnp-2011-Form-3-(15-02-2016).pdf | 2016-02-15 |
| 49 | 543-delnp-2011-Correspondence Others-(15-02-2016).pdf | 2016-02-15 |
| 50 | Petition Under Rule 137 [01-04-2016(online)].pdf | 2016-04-01 |
| 51 | Other Document [01-04-2016(online)].pdf | 2016-04-01 |
| 52 | 543-delnp-2011-Form-1-(06-04-2016).pdf | 2016-04-06 |
| 53 | 543-delnp-2011-Correspondence Others-(06-04-2016).pdf | 2016-04-06 |
| 54 | Petition Under Rule 137 [07-04-2016(online)].pdf | 2016-04-07 |
| 55 | Other Document [07-04-2016(online)].pdf | 2016-04-07 |
| 56 | 543-delnp-2011-Correspondence Others-(11-04-2016).pdf | 2016-04-11 |
| 57 | Other Patent Document [25-05-2016(online)].pdf | 2016-05-25 |
| 58 | 543-delnp-2011-Form-1-(26-05-2016).pdf | 2016-05-26 |
| 59 | 543-delnp-2011-Correspondence Others-(26-05-2016).pdf | 2016-05-26 |
| 60 | 543-DELNP-2011_EXAMREPORT.pdf | 2016-06-30 |
| 61 | Form 3 [08-07-2016(online)].pdf | 2016-07-08 |
| 62 | Other Patent Document [23-12-2016(online)].pdf | 2016-12-23 |
| 63 | HEARING ADJOURNMENT [22-02-2017(online)].pdf | 2017-02-22 |
| 64 | Other Patent Document [28-03-2017(online)].pdf | 2017-03-28 |
| 65 | 543-delnp-2011-ExtendedHearingNoticeLetter_26Dec2017.pdf | 2017-12-12 |
| 66 | 543-DELNP-2011-Written submissions and relevant documents (MANDATORY) [08-01-2018(online)].pdf | 2018-01-08 |
| 67 | 543-DELNP-2011-FORM 4 [19-03-2018(online)].pdf | 2018-03-19 |
| 68 | 543-DELNP-2011-RELEVANT DOCUMENTS [20-04-2018(online)].pdf | 2018-04-20 |
| 69 | 543-DELNP-2011-FORM-24 [20-04-2018(online)].pdf | 2018-04-20 |
| 70 | 543-DELNP-2011-PatentCertificate30-07-2018.pdf | 2018-07-30 |
| 71 | 543-DELNP-2011-IntimationOfGrant30-07-2018.pdf | 2018-07-30 |
| 72 | 543-DELNP-2011-PROOF OF ALTERATION [10-10-2018(online)].pdf | 2018-10-10 |