Diazabicyclic Derivatives As Nicotinic Acetycholine Receptor Ligands

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2; Z is selected from the group consisting of CH2, CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

Patent Information

Application #

Filing Date

13 July 2001

Publication Number

36/2007

Publication Type

INA

Invention Field

PHARMACEUTICALS

Status

Email

Parent Application

Applicants

ABBOTT LABORATORIES

CHAD O377/AP6D-2, 100 Abbott Park Road, Abbott Park, IL 60064-6050

Inventors

1. BUNNELLE, William, H.

1826 Victoria Way, Mundelein, IL 60060

2. CRISTINA, Daniela, Barlocco

Via G Frua, 20, I-20146 Milano

3. DAANEN, Jerome, F

4137 Nantucket Place, Racine, WI 53405

4. DART, Michael, J.

1026 Princeton Avenue, Highland Park, IL 60035

5. MEYER, Michael, D

25151 Amanda Court, Lake Villa, IL 60046

6. RYTHER, Keith, B.

862 Waterview Drive, Round Lake Park, IL 60073

7. SCHRIMPF, Michael, R.

327 Cambridge Drive, Grayslake, IL 60030

8. SIPPY, Kevin, B.

633 Wood Creek Dr., Antioch, IL 60613

9. TOUPENCE, Richard, B.

4239 N. Hermitage Avenue, Chicago, IL 60613

Specification

Documents

Application Documents

#	Name	Date
1	in-pct-2001-00831-mum-form 19(17-5-2004).pdf	2018-08-08
2	in-pct-2001-00831-mum-correspondence(ipo)-(27-1-2010).pdf	2018-08-08
3	in-pct-2001-00831-mum-correspondence(1-8-2002).pdf	2018-08-08
4	abstract1.jpg	2018-08-08