DESC:FORM 2

THE PATENTS ACT, 1970
(39 of 1970)
As amended by the Patents (Amendment) Act, 2005
&
THE PATENTS RULES, 2003
As amended by the Patents (Amendment) Rules, 2006

COMPLETE SPECIFICATION
(See section 10 and rule 13)

TITLE OF THE INVENTION
DISINFECTANT AND CLEANING COMPOSITION AND PREPARATION THEREOF

APPLICANTS
GRASIM INDUSTRIES LTD.

of address

Birlagram, Nagda, District Ujjain, Madhya Pradesh – 456331

PREAMBLE TO THE DESCRIPTION
The following specification particularly describes this invention and the manner in which it is to be performed:

FIELD OF THE INVENTION
[001] The present invention relates generally to disinfectant compositions, and more particular to a composition having combined property of disinfectant and cleaner in solid granular/ powder formulation.
DESCRIPTION OF THE BACKGROUND ART
[002] It is known that chlorine-based disinfectants such as those containing hypochlorite, for example calcium hypochlorite, sodium hypochlorite have long been recognized as being effective sanitizing agent for all types of micro-organisms. Calcium hypochlorite, for example, is usually for use as a treatment for water systems. Examples of calcium hypochlorite compositions are shown in various patents such as U.S. Pat. Nos. 3,793,216; 4,201,756; 4,876,003; 4,928,813; 4,145,306; 4,192,763; 4,692,335; 4,865,760; 4,961,872; 5,009,806; 5,164,109; and 5,753,602.
[003] These disinfectants also suffer from the shortcoming that they have a pungent odor of chlorine. Efforts have been made to provide a disinfectant with an odor neutralizer that masks the odor of disinfectants. However, traditional fragrances used to change the odor of the disinfectants when applied significantly compromise the effectiveness of chlorine based disinfectants.
[004] d provides a cleaner composition comprises an odor neutralizer wherein the odor neutralizer comprises a betaine compound, an amino alcohol, a polyol, and an ionone.
[005] US5075025A provides a disinfectant composition which is an aqueous solution containing hypochlorite and a tertiary aliphatic alcohol. The alcohol acts as an odor masking agent and as a stabilizer for hypochlorite ions.
[006] Above mentioned disinfectants are frequently used in hospitals, during dental surgeries, in kitchens, and in bathrooms to kill or otherwise control pathogenic or infectious organisms. Many types of disinfectants are known. However, all have inherent limitations and are typically used only in specific circumstances. Many of present day chlorine based disinfectant have essentially no functionality beyond disinfecting. The disinfectants have no cleaning properties to add value. They essentially have no cleaning capabilities.
[007] However, there is no single product which can eliminate odors, not merely masking odors, superiorly clean surfaces and also disinfect surfaces. This is partly attributed in large part to the incompatibility of the components.
[008] Therefore, there is a need for compositions that overcomes the problems in the prior art compositions.
SUMMARY OF THE INVENTION
[009] An object of the invention is to overcome the limitations of the prior art limitations.
[010] Another object of the invention is to provide a fragrant composition which can disinfectant and clean.
[011] In one exemplary embodiment, the composition comprises of a high stable bleach product, calcium hydroxide, at least one fragrance ingredient, at least one surfactant, at least one inert filler and at least one diluent.
[012] Combination of organic surfactant and fragrance with strong oxidizing agent like calcium hypochlorite is not safe considering fire hazard. Accordingly, another object of the invention is to overcome the above hazard by providing a method of preparing a fragranced composition which can disinfectant and clean.
DESCRIPTION OF THE INVENTION
[013] In describing and claiming the invention, the following terminology will be used in accordance with the definitions set forth below. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described herein. As used herein, each of the following terms has the meaning associated with it in this section. Specific and preferred values listed below for individual process parameters, substituents, and ranges are for illustration only; they do not exclude other defined values or other values falling within the preferred defined ranges.
[014] As used herein, the singular forms "a," "an," and "the" include plural reference unless the context clearly dictates otherwise.
[015] The terms “preferred” and “preferably” refer to embodiments of the invention that may afford certain benefits, under certain circumstances. However, other embodiments may also be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the invention
[016] As used herein, the term “disinfect” shall mean the elimination of many or all pathogenic microorganisms on surfaces with the exception of bacterial endospores.
[017] As used herein, the term “sanitize” shall mean the reduction of contaminants in the inanimate environment to levels considered safe.
[018] The term “surfactant”, as used herein refers to a substance that reduces surface tension when dissolved in water or water solutions, or that reduces interfacial tension between two liquids, or between a liquid and a solid.
[019] The term “inert carrier”, as used herein refers to inert substances capable of absorbing/adsorbing the fragrance, without directly affecting the activity of nor the fragrance or the end formulation.
[020] The present invention is directed to composition comprises of a high stable bleach product, a surfactant, calcium hydroxide, a source of fragrance and a diluent.
[021] In an embodiment, the composition further comprises of an inert carrier for said fragrance. Said inert carrier is selected from a group consisting of precipitated silica, diatomaceous earth, zeolites, nano clays, montmorillonite, preferably precipitated silica. The inert carrier is a porous powder material having high surface area.
[022] The high stable bleach product of the invention is preferably calcium hypochlorite. The calcium hypochlorite used in the composition of the invention is commercially available and can be either anhydrous or hydrated. The concentration of available chlorine in calcium hypochlorite can vary from 10 to 75%. In an embodiment, the amount of calcium hypochlorite is in the range of 50-90 wt% to the total weight of the composition.
[023] The compositions according to the present invention includes at least one surfactant. These surfactants may include anionic, nonionic, cationic or combinations thereof. Non-limiting examples of surfactants are discussed below.
[024] Suitable nonionic surfactants include, but are not limited to, ethoxylated alcohols, ethoxylated phenols, ethoxylated fatty acid esters, ethoxylated glycerol fatty acid esters, sorbitan fatty acid esters, glycerol fatty acid esters, coconut monoethanolamide ethoxylates, ethoxylated tall oil, ethoxylated polypropylene glycol, fatty acid alkanolamides such as coconut mono- and diethanolamide, amine oxides, n-alkyl pyrrolidones, alkyl polysaccharides such as sucrose esters and alkyl polyglycosides, alkyl phenol ethoxylates, ethoxylated castor oil, fatty acid ethoxylates, fatty amine ethoxylates, polyglycerol fatty acid esters, and alkyl adducts of ethylene-oxide-propylene oxide copolymers, as well as mixtures of two or more of the foregoing. In one embodiment, the nonionic surfactant comprises an ethoxylated alcohol such as Tomadol® 25-7, a C12-C15 ethoxylated alcohol available from Tomah Products, Inc. In another embodiment, the surfactant comprises an alkyl polyglycoside such as Glucopon® 425, believed to be a mixture of D-glucopyranoside or a similar C10-C16 alkyl oligomer and D-glucose, or Glucopon® 215, believed to comprise D-glucopyranoside or a similar C10-C16 alkyl oligomer, both available from Cognis. In another embodiment, the surfactant comprises an alkyl polyglycoside such as Dehypound WO7 available from Cognis, believed to comprise a mixture comprising a C10-C16 alkyl polyglycoside and a C8-C10 alcohol ethyoxylate propoxylate plus decene epoxide. In another embodiment, the surfactant comprises an alkyl polyglycoside such as Dehypound HSC 5515 available from Cognis, believed to comprise a mixture comprising a C10-C16 alkyl polyglycoside, and reaction products of epichlorohydrin and isodecyl alcohol-4EO. In yet another embodiment, the nonionic surfactant comprises Genapol® EP 1024 (formerly known as Sandoxylate® SX-408), an iso-C10-ethylene oxide-propylene oxide copolymer adduct. Another suitable nonionic surfactant is an ethoxylated nonylphenol available as a mixture with another proprietary surfactant as Monamulse DLE, available from Uniqema.
[025] Suitable anionic surfactants include, but are not limited to, linear and/or branched chain alkylbenzene sulfonates, alkyl sulfates, ether sulfates, secondary alkyl sulfates, a-olefin sulfonates, phosphate esters, sulfosuccinates, isethionates, carboxylates, and combinations comprising one or more of the foregoing anionic surfactants. Specific anionic surfactants include, for example, sodium lauryl sulfate, sodium lauryl ether sulfate, triethanolamine lauryl sulfate, magnesium lauryl sulfate, sulfosuccinate esters, ammonium lauryl sulfate, alkyl sulfonates, sodium lauryl sulfate, sodium alpha olefin sulfonates, alkyl sulfates, sulfated alcohol ethoxylates, sulfated alkyl phenol ethoxylates, sodium xylene sulfonate, alkylbenzene sulfonates such as triethanolamine dodecylbenzene sulfonate, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, xylene sulfonic acid, dodecylbenzene sulfonic acid, N-alkoyl sarcosinates such as sodium lauroyl sarcosinate, dialkylsulfosuccinates, N-alkoyl sarcosines such as lauroyl sarcosine, alkyl ether carboxylates, soaps including sodium, potassium, magnesium, calcium, alkanolamine, and amine soaps, and combinations comprising one or more of the foregoing anionic surfactants. In one embodiment, the anionic surfactant is sodium lauryl sulfate available as WITCOLATE® WAC LA from Akzo.
[026] Cationic surfactants include, but are not limited to, quaternary ammonium compounds including alkyl dimethyl benzyl ammonium chloride, dialkyl dimethyl ammonium chloride, alkyl trimethyl ammonium chloride or bromide, salts of organic or inorganic acids with fatty amines, fatty amine ethoxylates, and combinations comprising one or more of the foregoing cationic surfactants.
[027] In one embodiment, the surfactant in the composition is preferably anionic sodium lauryl sulfate in powder/ granular/ needle form.
[028] In one embodiment, the composition comprises of surfactant in the range of 1-5 wt% based on the total weight of the composition.
[029] In one embodiment, the composition comprises of at least one fragrance ingredient. In one embodiment, the fragrance may mask the pungent order of chlorine and/ or modify an unpleasant odor to a pleasant odor.
[030] Suitable fragrances include, but not limited to, for example, anethol, methyl heptine carbonate, ethyl aceto acetate, para cymene, nerol, decyl aldehyde, para cresol, methyl phenyl carbinyl acetate, undecylenic aldehyde, undecyl aldehyde, 2,6-nonadienal, nonyl aldehyde, octyl aldehyde, phenyl acetaldehyde, anisic aldehyde, benzyl acetone, ethyl-2-methyl butyrate, damascenone, damascone alpha, damascone beta, flor acetate, frutene, fructone, herbavert, iso cyclo citral, methyl isobutenyl tetrahydro pyran, isopropyl quinoline, 2,6-nonadien-1-ol, 2-methoxy-3-(2-methylpropyl)-pyrazine, methyl octine carbonate, tridecene-2-nitrile, allyl amyl glycolate, cyclogalbanate, cyclal C, melonal, gamma nonalactone, cis 1,3-oxathiane-2-methyl-4-propyl, benzaldehyde, benzyl acetate, camphor, camphene, carvone, borneol, bornyl acetate, decyl alcohol, eucalyptol, linalool, hexyl acetate, iso-amyl acetate, thymol, carvacrol, limonene, menthol, iso-amyl alcohol, phenyl ethyl alcohol, alpha pinene, a terpineol, citronellol, alpha thujone, benzyl alcohol, beta gamma hexenol, dimethyl benzyl carbinol, phenyl ethyl dimethyl carbinol, adoxal, allyl cyclohexane propionate, beta pinene, citral, citronellyl acetate, citronellal nitrile, dihydro myrcenol, geraniol, geranyl acetate, geranyl nitrile, hydroquinone dimethyl ether, hydroxycitronellal, linalyl acetate, phenyl acetaldehyde dimethyl acetal, phenyl propyl alcohol, prenyl acetate, triplal, tetrahydrolinalool, verdox, cis-3-hexenyl acetate, ethyl methyl phenyl glycidate, ethyl vanillin, heliotropin, indol, methyl anthranilate, vanillin, amyl salicylate, coumarin, ambrox, bacdanol, benzyl salicylate, butyl anthranilate, cetalox, ebanol, cis-3-hexenyl salicylate, lilial, gamma undecalactone, gamma dodecalactone, gamma decalactone, calone, cymal, dihydro iso jasmonate, iso eugenol, lyral, methyl beta naphthyl ketone, beta naphthol methyl ether, para hydroxyl phenyl butanone, 8-cyclohexadecen-1-one, oxocyclohexadecen-2-one/habanolide, florhydral, intreleven aldehyde, amyl cinnamic aldehyde, hexyl cinnamic aldehyde, hexyl salicylate, methyl dihydro jasmonate, sandalore, veloutone, undecavertol, exaltolide/cyclopentadecanolide, zingerone, methyl cedrylone, sandela, dimethyl benzyl carbinyl butyrate, dimethyl benzyl carbinyl isobutyrate, triethyl citrate, cashmeran, phenoxy ethyl isobutyrate, iso eugenol acetate, helional, iso E super, ionone gamma methyl, pentalide, galaxolide, phenoxy ethyl propionate, and combinations comprising one or more of the foregoing fragrances.
[031] In an embodiment, the composition of the present invention comprises of at least on diluent. Diluents are inert ingredients which lack anti-microbial activity but are desirable or necessary in anti-microbial preparations to improve the uniformity of the composition.
[032] Suitable diluents include, but not limited to, anhydrous/ hydrated Sodium sulphate, Potassium sulphate, Magnesium sulphate, Sodium chloride, Potassium chloride, Magnesium chloride, Calcium chloride, or combinations thereof.
[033] In an embodiment, the diluent is preferably sodium sulphate, in the range of 5-20 % W/W.
[034] In an embodiment, the composition comprises of hydrated lime in the range of 5-20 % W/W. Hydrated lime has been used as adsorbent of fragrance to ensure existence the same for long time and avoiding reaction with Calcium hypochlorite. Hydrated lime also been used to coat the surfactant to avoid any direct contact of organic surfactant with Calcium hypochlorite.
[035] In general, combination of organic surfactant and fragrance with strong oxidizing agent like calcium hypochlorite is not safe considering fire hazard. However, the claimed invention successfully overcame the limitation by a novel process for preparing the disinfectant and cleaner composition.
[036] In an embodiment, the present invention also provides a process for preparation of the disinfecting cum cleaning composition. The process comprising the steps of:
a) homogenizing a mixture of hydrated lime, at least one fragrance ingredient, at least one surfactant, an inert filler and at least one diluent; and
b) gradually adding a high stable bleach product to the mixture of step (a) and mixing the contents at a predetermined temperature.
[037] In an embodiment the maximum temperature in step (b) is in the range of 25oC to 55oC, preferably less than 40oC.
[038] The disinfectant cum cleaning composition provides for good cleaning and disinfecting while emitting pleasant fragrance.
[039] In an embodiment, the composition of the invention is reconstituted by dissolving the above composition in required quantity of water to provide 50 to 1000 ppm chlorine, preferably 500 ppm chlorine for proper disinfection of surface.
WORKING EXAMPLES
STEP 1: FRAGRANCE ENCAPSULATION PROCESS
[040] 1.25gm of silica was taken in a blender. 1.25 ml of pine oil was sprayed over silica and mixed thoroughly to obtain free flowing powder. To the above mixture, 10 gm of sodium lauryl sulfate was added and mixed. To the above mixture, 27.5gm calcium hydroxide was added slowly and stirred for 20 minutes. To the above, 30 gm sodium sulphate powder was gradually added and stirred for next 20 minute. The fragrance mixture of step 1 was stored for a duration of 24hours.
STEP 2: PREPARATION OF DISINFECTANT AND CLEANING COMPOSITION
[041] To the mixture of step 1, 180 gm of Calcium Hypochlorite was added in the ratio of 2.6: 1. The mixture was stirred at a speed of 12rpm to ensure dissipation of heat. Subsequently, the mixture was cooled to a temperature of less than 45°C.
[042] The effectiveness composition of present invention was compared with the commercially available disinfectant and the results are shown in table 1.
Product Type Domex®
Floor Cleaner Lizol®
Floor Cleaner Present invention

Conc. (Product) 0.60% 0.38% 0.125% 5%
Conc. (Chlorine) 120 ppm N/A 650 25550
Contact Time (min) 5 5 5 5
Test organism
Escherichia coli ATCC 10536 Bacteria 98.75 99.99149 99.87 99.999
Staphylococcus aureus ATCC 6538 Bacteria 70.48 99.24756 99.50 99.98518
Enterococcus hirae ATCC 10541 Bacteria 68.94 99.62821 90.40 99.90458
Pseudomonas aeruginosa ATCC 15442 Bacteria 77.5 98.33333 98.14 99.99926
Candida albicans ATCC 10231 Fungus 97.22 6.315789 99.77 >99.99
Spores of Aspergillus brasiliensis ATCC 16404 Fungus 95.41 8.791209 99.44 >99.999
MS2 Bacteriophage ATCC 15597 - B1 Virus 13.89 1.554404 50.00 >99.9999

Advantages:
1. Strong disinfectant in solid form with cleaning action
2. Ensuring availability of chlorine as disinfectant while masking pungent smell of the same.
3. Requires small amount to achieve 500 – 1000 ppm chlorine for ensuring proper disinfection.

,CLAIMS:Claims
We Claim

1) A disinfecting and cleaning composition comprising of:
(a) 50-90 wt% of high stable bleach product;
(b) 1-5 wt% of at least one surfactant,
(c) 5-20 % W/W of calcium hydroxide,
(d) at least a source of fragrance; and
(e) 5-20 wt% at least one diluent.

2) The composition as claimed in claim 1, further comprises of at least one inert carrier.

3) The composition as claimed in claim 1, wherein said high stable bleach is preferably calcium hypochlorite.

4) The composition as claimed in claim 1, wherein said surfactant is selected from a group consisting if anionic, non-ionic, cationic surfactants or combinations thereof.

5) The composition as claimed in claim 1, wherein said source of fragrance is pine oil.

6) The composition as claimed in claim 1, wherein said diluents is selected from a group consisting of anhydrous/hydrated sodium sulphate, potassium sulphate, magnesium sulphate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, or combinations thereof.

7) A process for preparation of the disinfecting cum cleaning composition comprising the steps of:
a) homogenizing a mixture of hydrated lime, at least one fragrance ingredient, at least one surfactant and at least one diluent; and
b) gradually adding a high stable bleach product to the mixture of step (a) and mixing the contents at a predetermined temperature.

8) The method as claimed in claim 6, wherein temperature of step (b) is in the range of 25oC to 55oC.