DITH I AZOCANE COMPOUNDS FOR THE COSMETIC USE THEREOF The present invention relates to the cosmetic use of dithiazocane to especially cosmetic containing same and to the cosmetic use thereof for depigmenting bleaching keratin in particular human At various periods in their some people develop darker more colored blemishes on their and more especially on the neck and the which give the skin These blemishes are especially due to a high concentration of melanin in the keratinocytes located at the surface of the The use of highly effective inoffensive topical depigmenting substances is most particularly sought for the purpose of reducing treating pigmentary The mechanism of formation of the pigmentation of the of the formation of is particularly complex and the following main Tyrosine Dopa Dopaquinone Dopachrome Melanin Tyrosinase dihydroxyl oxygen oxidoreductase EC 1 is the essential enzyme involved in this sequence of In it catalyzes the conversion reaction of tyrosine to give dopa by virtue of its hydroxylase and the conversion reaction of dopa to give by virtue of its oxidase This tyrosinase acts only when it is in mature form under the effect of certain biological A substance is acknowledged as being depigmenting if it acts directly on the vitality of the epidermal melanocytes where melanogenesis takes if it interferes with one of the steps of melanin either by inhibiting one of the enzymes involved in or by inserting itself as a structural analog of one of the chemical compounds of the melanin synthesis which chain can then be thus ensuring Arbutin and kojic acid are known as skin depigmenting There remains a need for a novel agent for bleaching keratin in particular human which is effective and does not have the drawbacks of the depigmenting agents known from the prior that is to say which is toxic for keratin in particular the while also being stable in a especially a novel agent which is stable example chemical stability or and especially having an odor a color which is stable over or else alternatively which has a reinforced action so as to be able to be used in a smaller which considerably reduces the side effects Cyclic disulfide derivative compounds are known in the prior art for the pharmaceutical use thereof as medicaments of use for treating ischemic cardiac diseases and the caused by oxidative especially in document WO the use of these compounds to bleach keratin especially human is not suggested by this In this the Applicant has surprisingly and that certain dithiazocane compounds have good depigmenting even at low without showing any The invention relates to the cosmetic use of at least one compound of formula or of a composition containing at least one compound of formula as defined as an agent for lightening depigmenting keratin especially human a subject of the invention is a composition in a physiologically acceptable at least one compound of formula as defined Another subject of the invention is a cosmetic treatment process for lightening bleaching keratin especially human comprising the application to the keratin and especially human of at least one compound of formula as defined below or of a composition containing In another one subject of the invention is some compounds of formula as defined below for the dermatological use thereof for depigmenting the The compounds of formula in accordance with the as defined make it possible to depigment lighten or even human They are especially intended to be applied to the skin of individuals exhibiting brownish pigmentation blemishes or liver or to the skin of individuals wishing to reduce soften the appearance of a brownish color caused by For the purposes of the present the is intended to mean human keratin and in particular the More denote human and even more particularly the skin of the neck and a subject of the invention is the cosmetic use of at least one compound of formula or of a composition containing at least one compound of formula as an agent for lightening depigmenting keratin especially human said compounds corresponding to the following formula in R denotes a radical or R1 denotes a hydrogen atom or a alkyl a hydrogen a said alkyl group being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from alkoxy at least one of the ring members of said denoting a ketone optionally substituted especially with one or more identical or different radicals chosen from C4 said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as a said alkenyl radical being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as an optionally substituted aryl or heteroaryl Ra and Rb independently a hydrogen a said alkyl group being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as a said alkenyl group being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as an aryl or heteroaryl optionally substituted especially with one or more identical or different radicals chosen from such as a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from alkoxy at least one of the ring members of said heterocycloalkyl radical denoting a ketone or else Ra and Rb together with the nitrogen atom to which they are an optionally substituted such as piperidino or and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a The denotes the point of attachment of the radical to the rest of the For the purposes of the present the of formula T to and to in particular compounds 1 and is intended to mean the compounds as defined in the present and also the solvates thereof such as the optical and geometrical isomers the tautomers and the organic or mineral base or acid salts The acceptable solvates of the compounds used in the present invention comprise conventional solvates such as those formed during the last step of the preparation of said compounds due to the presence of Mention may be by way of of the solvates due to the presence of water or of linear or branched such as ethanol or The salts of the compounds which comprise at least one acid function can be chosen from metal for example aluminum zinc manganese or copper alkali metal for example lithium sodium or potassium or metal for example calcium or magnesium They can also be ammonium derivatives of formula or organic salts such as ammoniums of formula NY3 denoting an organic the Y radicals being identical or it being possible for two or three Y radicals to in a ring with the nitrogen atom which carries them or it being possible for NY3 to denote an aromatic The organic amines are for example for instance triethylamine or or for instance or or for instance bicyclohexylamine or or pyridines and the for example quinine or or amino acids which are basic in for instance lysine or The salts of the compounds of formula which comprise at least one amine function can also be salts of an organic acid such as citric lactic tartaric aspartic glutamic acetic formic trifluoroacetic hydrochloric glycolic acid or malic In the case where the compounds according to the invention are in salt the cations are of course in an amount which ensures the of the compounds of formula The salts of the compounds of formula according to the invention which comprise at least one acid function can advantageously be chosen from the metal salts and the alkali metal salts and and the earth metal salts and According to another the salts of the compounds of formula according to the invention which comprise at least one acid function can advantageously be chosen from preferably from the salts of amino acids which are basic in for instance lysine or arginine or from diethanolamine salts or triethanolamine For the purposes of the present invention and unless otherwise the saturated or unsaturated and optionally fused rings may also be optionally the radicals are linear or generally particularly preferably alkyl as alkyl mention may especially be made of and the radicals are linear or unsaturated especially and more particularly comprising one or more conjugated or unconjugated double such as prenyl and in particular radicals are monocyclic or fused or unfused preferentially comprising from 6 to 30 carbon atoms and at least one ring of which is the aryl radical is chosen from a a a an an and a more aryl denotes the aryl radicals may be substituted especially with one or more identical or different radicals chosen from and more particularly and more particularly radicals are alkyloxy radicals with alkyl as previously the alkyl part of the alkoxy generally being preferably more preferentially such as propoxy and when mention is made of this implies that the alkoxy group can represent an alkenyloxy group with alkenyl as previously radicals are saturated or partially aromatic cycloalkyl preferably cyclopentyl and cyclohexyl the cycloalkyl radicals may be substituted cycloalkyl in particular substituted with carboxylic hydroxyl or amine at least one of the ring members thereof may be a radicals are saturated or partially heterocyclic radicals comprising from 4 to 8 ring which comprise from 1 to 3 especially chosen from sulfur and preferably the piperazino and tetrahydropyran preferably tetrahydrofuran or the heterocycloalkyl radicals may be substituted in particular substituted with carboxylic amine and ketone especially with hydroxyl or ketone the or radicals may be substituted with at least one radical chosen preferably and more preferentially such as said alkyl radical being optionally substituted with one or more radicals chosen from optionally unsaturated amino substituted with two identical or different alkyl optionally bearing at least one hydroxyl or it being possible for the two radicals to with the nitrogen atom to which they are a saturated or unsaturated heterocycle comprising from 5 to 7 ring preferably 5 or 6 ring said heterocycle being optionally substituted optionally comprising another heteroatom identical to or different from especially alkoxy such as especially alkoxycarbonyl such as methoxycarbonyl or preferentially or or or optionally substituted with a preferentially the or or radicals may be substituted with at least one radical chosen especially alkoxy such as C especially alkoxycarbonyl such as methoxycarbonyl or preferentially or or or optionally substituted with a preferentially the radicals are radicals in at least one one or more heteroatoms chosen in particular from N and preferably O or optionally substituted in particular with one or more amine or ketone and at least one ring of which is These rings may contain one or more oxo groups on the carbon atoms of mention may especially be among the heteroaryl radicals that may be of and pyrimidinyl the heteroaryl groups are fused such as coumarinyl or isocoumarinyl it being possible for these groups to be in particular with one or more OH a radical denotes an aryl radical or a heteroaryl a radical denotes a heterocycloalkyl radical or a cycloalkyl According to a particular the compounds of formula are of R In other the configuration of the carbon of the dithiazocane ring bearing the radical is the R According to a particular the compounds of formula are such that Ri denotes a group such as methyl or a hydrogen preferably a hydrogen According to a particular the compounds of formula are such that R denotes an being as defined According to a particular the compounds of formula are such that R denotes a radical in which denotes a hydrogen atom or a in particular a hydrogen atom or a group such as or According to a particular the compounds of formula are such that R denotes a radical in which denotes a in particular a optionally substituted with one or more identical or different radicals chosen from heterocycloalkyl substituted with one or more identical or different radicals chosen from alkoxy one of the ring members of said heterocycloalkyl denotes a ketone preferably substituted with one or more identical or different radicals chosen from hydroxyalkyl one of the ring members of said heterocycloalkyl denotes a ketone optionally substituted with one or more identical or different radicals chosen from preferably phenyl substituted with one or more identical or different radicals chosen from hydroxyl or such as According to a particular the compounds of formula are such that R denotes a radical in which denotes a alkyl group such as said alkyl group being interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as preferably interrupted with one or more oxygen According to a particular the compounds of formula are such that R denotes a radical in which denotes a radical of formula in which Rh and Rk independently of one another denote a hydrogen atom or a methyl it being understood that Rh and Rk preferably cannot simultaneously denote a methyl Ri denotes H or y denotes an integer from 1 to 10 inclusive values According to a particular the compounds of formula are such that R denotes a radical in which denotes a in particular a optionally substituted with one or more identical or different radicals chosen from heterocycloalkyl substituted with one or more identical or different radicals chosen from alkoxy one of the ring members of said heterocycloalkyl denotes a ketone preferably substituted with one or more identical or different radicals chosen from hydroxyalkyl one of the ring members of said heterocycloalkyl denotes a ketone optionally substituted with one or more identical or different radicals chosen from preferably phenyl substituted with one or more identical or different radicals chosen from hydroxyl or such as said alkenyl radical preferably being substituted with a phenyl substituted with one or more identical or different radicals chosen from hydroxyl or such as According to a particular the compounds of formula are such that R denotes a radical in which Ra and Rb are as defined According to a particular the compounds of formula are such that R denotes a radical in which Ra and Rb independently a hydrogen a in particular group such as methyl or According to another particular the compounds of formula are such that R denotes a radical in which Ra denotes a hydrogen atom and Rb represents a in particular group such as said alkyl group being optionally substituted with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from According to another particular the compounds of formula are such that R denotes a radical in which Ra denotes a hydrogen atom and Rb represents a radical of the following formula in i 0 or 1 R4 represents a hydrogen atom or a group optionally substituted with one or more groups chosen from with and which are identical or representing an oxygen or sulfur and RC and which are identical or representing a hydrogen atom or a and represent an group such as such as optionally substituted especially with a hydroxyl with and Rc as defined in particular represents an oxygen represents an oxygen atom or an group such as and Rc represents a hydrogen with representing an sulfur or selenium atom or an NH group and Rc is as defined in R4 represents a group optionally substituted with with and which are identical or representing an oxygen or sulfur and RC and which are identical or representing a hydrogen atom or a preferably and represent an group such as when Ra and R4 together with the nitrogen atom which bears Ra and with the carbon atom which bears a saturated or preferably heterocycle such as a pyrrolidine R6 a hydroxyl radical a saturated or unsaturated or an with Rf and which are identical or representing a hydrogen or a R6 denotes a hydroxyl radical or a saturated or unsaturated alkoxy radical such as methyl or According to another particular the compounds of formula are such that R denotes a radical NRaRb in which Ra denotes a hydrogen atom and Rb represents a radical of formula as defined in which formula R6 denotes a hydroxyl radical or a saturated or unsaturated radical such as methyl or and R4 represents a hydrogen atom or R4 is chosen from radicals to described when Ra and R4 together with the nitrogen atom which bears Ra and with the carbon atom which bears a saturated or heterocycle of formula A1 A2 or A3 preferably such as a pyrrolidine ring a saturated heterocycle of formula A1 or A2 or A1 A2 A3 According to another particular the compounds of formula are such that R denotes a radical NRaRb in which Ra denotes a hydrogen atom and Rb represents a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from at least one of the ring members of said heterocycloalkyl radical denoting a ketone the heterocycloalkyl radical is a According to another particular the compounds of formula are such that R denotes a radical in which Ra denotes a hydrogen atom and Rb represents a glucopyran radical of formula in which formula Re and which are identical or represent a hydroxyl the alkyl part of which may optionally be especially with one or more hydroxyl and an NR1R2 group with R1 and which are identical or chosen from a hydrogen and it being understood that one of the radicals Re and Rf represents a covalent bond with the nitrogen atom of the NRaRb the configuration of said compounds of formula being D or preferably and of a or b anomeric the compounds of formula and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a are such R denotes a radical or Ri denotes a hydrogen atom or a group such as preferably a hydrogen a hydrogen or a in particular said alkyl group being optionally substituted with one or more identical or different radicals chosen heterocycloalkyl substituted with one or more identical or different radicals chosen from alkoxy one of the ring members of said heterocycloalkyl denotes a ketone preferably substituted with one or more identical or different radicals chosen from hydroxyalkyl one of the ring members of said heterocycloalkyl denotes a ketone optionally substituted with one or more identical or different radicals chosen from preferably phenyl substituted with one or more identical or different radicals chosen from hydroxyl or such as or a group such as said alkyl group being interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as preferably interrupted with one or more oxygen or a in particular optionally substituted with one or more identical or different radicals chosen from heterocycloalkyl substituted with one or more identical or different radicals chosen from alkoxy one of the ring members of said heterocycloalkyl denotes a ketone preferably substituted with one or more identical or different radicals chosen from hydroxyalkyl one of the ring members of said heterocycloalkyl denotes a ketone optionally substituted with one or more identical or different radicals chosen from preferably phenyl substituted with one or more identical or different radicals chosen from hydroxyl or such as said alkenyl radical preferably being substituted with a phenyl substituted with one or more identical or different radicals chosen from hydroxyl or such as Ra a hydrogen a in particular group such as methyl or Rb a in particular group such as said alkyl group being optionally substituted with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from a in particular said alkenyl group being optionally substituted with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from C4 alkoxy at least one of the ring members of said heterocycloalkyl radical denoting a ketone preferably a radical of formula as defined or else Ra and Rb together with the nitrogen atom to which they are an optionally substituted such as piperidino or and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a the compounds of formula are chosen from the compounds to and from the compounds to below and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a Even more the compounds of formula are chosen from the compounds 1 to 4 below and also the salts the solvates alone or in a from the compounds to and from compounds to described above and also the salts the solvates and the optical geometrical isomers including enantiomers and and the racemates alone or in a The invention relates to the cosmetic use of at least one compound of formula as defined previously or of a composition containing at least one compound of formula and more particularly of at least one compound chosen from the compounds T to and from the compounds to as described more particularly chosen from the compounds 1 and 2 described and even more preferentially the compound 1 as an agent for lightening depigmenting keratin especially the Novel compounds Some compounds of formula are novel and constitute another subject of the another subject of the invention is the compounds of formula as defined with the exception of the following compounds Cp1 to and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a another subject of the invention relates to the compounds of formula which are in R is as defined previously for the compounds of formula Sub denotes a group such as and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a Another subject of the invention relates to the compounds of formula which are also novel in which formula denotes a radical or a said alkyl group being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from alkoxy at least one of the ring members of said denoting a ketone optionally substituted especially with one or more identical or different radicals chosen from C4 said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as a said alkenyl radical being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as an optionally substituted aryl or heteroaryl Ta represents a radical chosen a hydrogen a said alkyl group being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as a said alkenyl group being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as an aryl or heteroaryl optionally substituted especially with one or more identical or different radicals chosen from such as a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from alkoxy at least one of the ring members of said heterocycloalkyl radical denoting a ketone Tb represents a radical chosen a hydrogen a said alkyl group being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as a said alkenyl group being optionally especially with one or more identical or different radicals chosen from optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as an aryl or heteroaryl optionally substituted especially with one or more identical or different radicals chosen from such as a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from alkoxy at least one of the ring members of said heterocycloalkyl radical denoting a ketone or else Ta and Tb together with the nitrogen atom to which they are an optionally substituted such as piperidino or and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a As examples of novel compounds of formula and of formula mention may be made of the following compounds to and to and also the salts the solvates thereof and including enantiomers and and the racemates alone or in a and in particular the R isomers of the carbon in position 4 of the dithiazocane ring of said Table 1 The numbers in the table correspond to the numbers used in the examples and also the salts the solvates thereof and including enantiomers and and the racemates alone or in a The compounds of the invention may be prepared according to the following scheme 1 making use of the methods known and described for those skilled in the art in Synthesis and pharmacological activities of novel cyclic disulfide and cyclic sulfide derivatives as hepatoprotective by Susumu et al from Chemical Pharmaceutical 41 1993 and in patent EP Scheme 1 after obtaining the ring having a carboxylic acid the latter may be converted to ester or amide according to reactions known to those skilled in the art and described Comprehensive Organic second by RC ISBN 2010 COMPOSITION The compounds of formula according to the invention have a most particular application in the cosmetics Another subject of the invention is a preferably a cosmetic containing at least one compound of formula in particular a composition containing at least one compound chosen from the compounds T to and to described and more preferentially containing at least one compound chosen from the compounds 1 and 2 described most particularly containing the compound Another subject of the invention is a especially a cosmetic containing at least one novel compound of formula or of formula as described in particular containing at least one novel compound of formula more particularly containing at least one compound of formula to and to as defined said composition containing in particular at least one novel compound of formula to and to in R isomer form of the carbon bearing the radical in the novel compounds of formula The preferably cosmetic according to the invention is advantageously a composition intended for topical In a variant of the the composition may be a dermatological or pharmaceutical especially intended for topical The preferably cosmetic according to the invention advantageously in a physiologically acceptable at least one compound of formula as described in particular at least one compound chosen from the compounds T to and to described preferably at least one compound chosen from the compounds 1 or 2 described previously and most particularly the compound 1 described The term acceptable is intended to mean a medium that is compatible with human keratin materials such as the skin of the such as the neck or The compound of formula may be present in the preferably cosmetic according to the invention at an amount that may be between and by preferably between and by especially from to by weight relative to the total weight of the The preferably cosmetic according to the invention may comprise water adjuvants usually used in the cosmetics Mention may be made especially of organic especially C6 especially oils and silicone cosmetic active organic or mineral photoprotective preserving odor These optional cosmetic adjuvants may be present in the cosmetic composition in a proportion of from to by weight and especially from to by weight relative to the total weight of the In any these and the proportions will be chosen by those skilled in the art such that the advantageous properties of the compounds according to the invention are or are not adversely affected by the envisaged As active it will be advantageous to introduce into the composition according to the invention at least one compound chosen desquamating organic or mineral photoprotective additional depigmenting agents other than the compounds of formula of the agents for stimulating the synthesis of dermal or epidermal macromolecules for preventing their agents for stimulating fibroblast keratinocyte proliferation or for stimulating keratinocyte tensioning agents agents acting on the agents acting on the energy metabolism of and mixtures The preferably cosmetic according to the invention may in particular be in any presentation form normally used in the cosmetics and especially in the form of an aqueous or which is optionally a dispersion of the lotion which is optionally a an or or multiple example or an aqueous a dispersion of oil in an aqueous phase by means of these spherules possibly being polymer nanoparticles such as nanospheres and nanocapsules better lipid vesicles of the ionic nonionic aqueous or oily These compositions are prepared according to the usual The cosmetic composition according to the invention may constitute a skincare and especially a treating or care cream for the the the the major anatomical folds or the body example day night foundation creams or a fluid a a protective or care body milk or an a skincare gel or such as a cleansing Another subject of the invention is a cosmetic process for lightening bleaching keratin especially the comprising the application of the preferably cosmetic previously More it is a cosmetic process for lightening bleaching the The invention is illustrated in greater detail by the following nonlimiting The various examples below describe various synthesis routes making it possible to obtain the compounds of formula In these means room Examples 1 and Synthesis of compounds 1 and 2 By Susumu et from Chemical Pharmaceutical 41 1993 and in patent EP 356006A1 To a solution of 130 in 440 ml of ethyl the following are a solution of iodine 130 in 440 ml of then between and a solution of thethylamine 290 in 430 ml of EtOAc over 3 The mixture is stirred at this temperature for 1 The triethylammonium iodide precipitate formed is then and the filtrate is washed with 1 N hydrochloric sodium bisulfite at 1 in water then a saturated sodium chloride After concentrating the filtrate under a precipitate forms after is recrystallized in a mixture to give compound 1 The MS and NMR spectra are in accordance with the desired Diazomethane dissolved in ether at is added to a solution of compound 1 1 acidified with hydrochloric acid N in in methyl acetate At the end of the the reaction mixture is stirred for 10 minutes before adding 8 ml of acetic acid After concentration under the crude product is purified by silica column to give compound 2 with a yield of The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a solution of compound 1 500 in anhydrous Tetrahydrofurane 5ml at we added oxalyle chloride 1 and 2 drops of The mixture was stirred for 4 hours and concentrated with The residue was solubilized in a mix of and cool at bubbling with ammonia during 1 hour and the stirring is continued for 16 hours at room The mixture was concentrated under reduced pressure and the residue was purified by chromatography on inverse silica gel to and lyophilized to give compound a yield of The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a solution of compound 1 200 in anhydrous 4 we added Me2NH 1 hexafluorophosphate 1 355 and The mixture was stirred for 20 hours at room Water was added to the mixture and extracted with Dicloromethane ethyl acetate time and dichloromethane 1 The organic layer was mixed and dried with filtered and concentrated under reduced The residue obtained is purified by chromatography on silica gel to give compound with a yield of The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a solution of compound 1 300 in dichloromethane we added successively 1 395 Ethanol and The mixture was stirred for 16 hours at room Brine was added to the mixture and extracted with ethyl acetate The organic layer was mixed and dried with filtered and concentrated under reduced The residue obtained is purified by chromatography on silica gel to give compound a yield of 71 The MS and NMR spectra are in accordance with the desired product Example Synthesis of compound To a solution of compound 1 250 in dichloromethane we added successively 1 328 Isopropanol and The mixture was stirred for 16 hours at room Brine was added to the mixture and extracted with ethyl acetate The organic layer was mixed and dried with filtered and concentrated under reduced The residue obtained is purified by chromatography on silica gel to give compound with a yield of The MS and NMR spectra are in accordance with the desired product Example Synthesis of compound T To a solution of compound 1 400 in anhydrous we added 596 1 hexafluorophosphate 1 732 and The mixture was stirred for 40 hours at room Water was added to the mixture and extracted with dichloromethane 1 AcOEt time and dichloromethane 1 The organic layer was mixed and dried with filtered and concentrated under reduced The residue obtained is purified by chromatography on silica gel acetone to to give intermediate compound with a yield of The compound obtained 370 previously was dissolved in anhydrous DCM 10 HCI was added at The mixture was stirred for 20 hours at after it was concentrated under reduced The residue is purified by chromatography on silica gel times to and 1 time to give compound a yield of The MS and NMR spectra are in accordance with the desired product Example Synthesis of compound To a solution of compound 1 400 in anhydrous we added at under 1 hexafluorophosphate 1 732 and diisopropylethylamine 1 The mixture was stirred for 40 hours at room temperature after it was concentrated under reduced The residue obtained is purified by chromatography on silica gel to to give compound a yield of The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a solution of compound 1 150 in anhydrous we added at under propanoate 1 187 1 hexafluorophosphate 1 286 and DIEA ml The mixture was stirred for 40 hours at room temperature after it was concentrated under reduced The residue obtained is purified by chromatography on silica gel to to give compound a yield of The MS and NMR spectra are in accordance with the desired product Example Synthesis of compound To a solution of compound 1 250 in dichloromethane 5 ml we added successively 1 328 and 26 The mixture was stirred for 16 hours at room Brine was added to the mixture and extracted with ethyl acetate The organic layer was mixed and dried with filtered and concentrated under reduced The residue obtained is purified by chromatography on silica gel to give compound a yield of The MS and NMR spectra are in accordance with the desired Example 11 Synthesis of compound To a solution of compound 1 250 in dichloromethane we added successively 1 328 1 1 and dimethylaminopyridine 26 The mixture was stirred for 16 hours at room Brine was added to the mixture and extracted with ethyl acetate The organic layer was mixed and dried with filtered and concentrated under reduced The residue obtained is purified by chromatography on silica gel to give compound 1 with a yield of The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a solution of compound 1 400 with 293 in 4 ml at we added slowly dicyclohexylcarbodiimide 1 526 in solution in Dimethylformamide 3 The mixture was stirred for 2 hours at room temperature and a solution of glycine 140 with KFICO3 340 in water was The mixture was stirred for 16 hours at room temperature and cool with ice Water 5 was added and slowly formic acid was added pH The mixture was The crude was purified by chromatography on inverse silica gel to to give compound with a yield of The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a solution of compound 1 300 in anhydrous 6 we added reactant heptylamine 1 hexafluorophosphate 1 eq 549 and The mixture was stirred for 40 hours at room Water was added to the mixture and extracted with Dicloromethane 1 ethyl acetate time and dichloromethane 1 The organic layer was mixed and dried with filtered and concentrated under reduced The residue obtained is purified by chromatography on silica gel and to give compound with a yield of The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a suspension of 400 in pyridine 8ml we added successively hexamethyldisilazane and chlorotrimethylsilane The mixture was stirred for 20 hours at room temperature after it was concentrated under reduced pressure with toluene and purified by chromatography on silica gel A colorless oil is yield 63 To a solution of compound 1 178 in we added successively the compound synthetized previously 390 1 hexafluorophosphate 345 and The mixture was stirred for 20 hours at room Water was added and the solution was The crude was used for the next The crude was solubilized in a mix of after silicagel and a little of AcOH was The mixture was stirred for 2 days at room temperature before to be filtered and concentrated under reduced The crude was purified by chromatography on inverse silica gel to We obtained a white powder with global yield of 77 for the three The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a solution of compound 1 400 in dichloromethane Dimethylformamide we added 1 526 mixture was stirred for 5 min at room temperature after solketal and 20 was The mixture was stirred for 16 hours at room Dicloromethane was added and the mixture was filtered on The solution obtained was concentrated under reduced pressure and purified by chromatography on silica gel A white powder is yield 23 A solution of the compound synthetized previously 258 in AcOH 8 with water was stirred for 2 days at room temperature and A white hygroscopic powder quantitative yield was The MS and NMR spectra are in accordance with the desired Example Synthesis of compound To a suspension of compound above 2 in pyridine we added successively hexamethyldisilazane and chlorotrimethylsilane The mixture was stirred for 16 hours at room temperature after it was concentrated under reduced pressure with toluene and purified by chromatography on silica gel A pale yellow oil is yield 85 To a solution of previous compound above in EtOH 30 we added NaBH4 The mixture was stirred for 1 hour at room The mixture is then poured in saturated aqueous solution of filtered and concentrated under reduced The residue was purified by chromatography on silica gel We obtained a colorless oil compound with yield 62 To a solution of compound 1 200 in anhydrous tetrahydrofurane 16 ml we added 1 165 and the mixture was stirred at room temperature for Compound below 1 416 in solution in anhydrous THF was added and the mixture was heated at 60 during 2 After the mixture was diluted in a solution of 20 and a little of AcOH 1 was The solution was stirred for 2 days and concentrated under reduced pressure with The oil obtained was purified by chromatography on inverse silica gel to We obtained a white powder with yield 19 The MS and NMR spectra are in accordance with the desired product Example Demonstration of the depigmenting activity The measurement of the depigmenting activity of melanin of compounds of formula was performed by assaying normal human melanocytes in vitro as First of normal human melanocytes are cultured and dispensed into After 24 the culture medium was replaced with a medium containing compounds of formula to be The cells were incubated 72 hours before measurement of the final optical which measures the amount of melanin produced by the A dose effect is performed using a wide concentration range of the compounds by making the concentrations and the melanin measurements it is possible to determine an IC50 in concentration at which a decrease in melanin synthesis is Various test campaigns were conducted and the results collated in the table The compounds of formula showed a strong depigmenting Coculture A biological test demonstrated the depigmenting activity of compound 1 The effect of compound 1 was measured according to the method described in patent and also in the article by Krien and 1 This test is performed on a coculture of keratinocytes and The following were determined for the test the the inhibitory activity on melanin by estimating the melanin optical The IC50 values for which of the melanin synthesis is were Compound 1 IC50 Compound IC50 Compound IC50 Compound IC50 1 Compound IC50 1 Compound IC50 1 Compound IC50 Example Other Demonstration of the depigmenting activity Compositions comprising 300 pM of compound 1 in DMSO were applied to samples of pigmented reconstructed epidermis EP 1 878 The control is The melanin was quantified by image analysis on histological slices after staining with Fontana Masson Each sample of coloured epidermis is photographed over its entire length using a camera connected to a The melanin is thresholded and the number of melanin pixels is measured in each field using automated image analysis A statistical test is performed in order to determine the significance of the measurements Whitney see 1 The pigmented reconstructed epidermis standard study model was published Regnier Duval Galey Philippe Lagrange Tuloup Schmidt Cellular and Molecular Melanocyte and pigmented reconstructed human models to study modulation of Significant depigmenting activity was evaluated at 300 mM for compound 1 significant depigmenting Example Cosmetic composition A skin depigmenting composition is comprising Compound 1 2 g PEG400 68 g Ethanol 30 g The composition applied to the skin makes it possible to lighten the skin of the face and especially to attenuate brown Example gel A skin depigmenting gel is comprising by Compound 1 Carbomer 981 from 1 Preservative qs Water qs The composition applied to the skin makes it possible to attenuate brown insufficientOCRQuality

CLAIMS 1 The cosmetic as an agent for lightening depigmenting keratin of at least one compound of formula in R denotes a radical or R1 denotes a hydrogen atom or a alkyl a hydrogen a said alkyl group being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from alkoxy at least one of the ring members of said denoting a ketone optionally substituted especially with one or more identical or different radicals chosen from C4 said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as a said alkenyl radical being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as an optionally substituted aryl or heteroaryl Ra and Rb independently a hydrogen a said alkyl group being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as a said alkenyl group being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as an aryl or heteroaryl optionally substituted especially with one or more identical or different radicals chosen from such as a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from alkoxy at least one of the ring members of said heterocycloalkyl radical denoting a ketone or else Ra and Rb together with the nitrogen atom to which they are an optionally substituted such as piperidino or and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or as a The cosmetic use as claimed in claim 1 characterized in that said compound of formula are of R The cosmetic use as claimed in claim 1 or 2 of at least one compound of formula in which Ri denotes a group such as methyl or a hydrogen preferably a hydrogen The cosmetic use as claimed in any one of claims 1 to 3 of at least one compound of formula in which R denotes an in which a hydrogen atom or a in particular a hydrogen atom or a group such as or a in particular alkyl optionally substituted with one or more identical or different radicals chosen heterocycloalkyl substituted with one or more identical or different radicals chosen from alkoxy one of the ring members of said heterocycloalkyl denotes a ketone preferably substituted with one or more identical or different radicals chosen from hydroxyalkyl one of the ring members of said heterocycloalkyl denotes a ketone optionally substituted with one or more identical or different radicals chosen from preferably phenyl substituted with one or more identical or different radicals chosen from hydroxyl or such as or a alkyl group such as said alkyl group being interrupted with one or more heteroatoms such as S and with R5 representing a hydrogen atom or a group such as preferably interrupted with one or more oxygen or a radical of formula in which Rh and Rk independently of one another denote a hydrogen atom or a methyl it being understood that Rh and Rk preferably cannot simultaneously denote a methyl Ri denotes H or y denotes an integer from 1 to 10 or a in particular optionally substituted with one or more identical or different radicals chosen heterocycloalkyl substituted with one or more identical or different radicals chosen from alkoxy one of the ring members of said heterocycloalkyl denotes a ketone preferably substituted with one or more identical or different radicals chosen from hydroxyalkyl one of the ring members of said heterocycloalkyl denotes a ketone optionally substituted with one or more identical or different radicals chosen from preferably phenyl substituted with one or more identical or different radicals chosen from hydroxyl or such as The cosmetic use as claimed in any one of claims 1 to 3 of at least one compound of formula in which R denotes an NRaRb in Ra and Rb independently represent a hydrogen atom or a in particular such as methyl or or Radenotes a hydrogen atom and Rb represents a in particular such as said alkyl group being optionally substituted with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from or Ra denotes a hydrogen atom and Rb represents a radical of following formula in i 0 or 1 R4 represents a hydrogen atom or a group optionally substituted with one or more groups chosen from with and which are identical or representing an oxygen or sulfur and RC and which are identical or representing a hydrogen atom or a and represent an group such as such as optionally substituted especially with a hydroxyl with and Rc as defined in particular represents an oxygen represents an oxygen atom or an group such as and Rc represents a hydrogen with representing an sulfur or selenium atom or an NH group and Rc is as defined in R4 represents a group optionally substituted with with and which are identical or representing an oxygen or sulfur and RC and which are identical or representing a hydrogen atom or a preferably and represent an group such as when Ra and R4 together with the nitrogen atom which bears Ra and with the carbon atom which bears a saturated or preferably heterocycle such as a pyrrolidine R6 a hydroxyl radical a saturated or unsaturated or an with Rf and which are identical or representing a hydrogen or a R6 denotes a hydroxyl radical or a saturated or unsaturated alkoxy radical such as methyl or or Ra denotes a hydrogen atom and Rb represents a radical of formula as defined in which formula R6 denotes a hydroxyl radical or a saturated or unsaturated radical such as methyl or and R4 represents a hydrogen atom or is chosen from radicals to described when Ra and R4 together with the nitrogen atom which bears Ra and with the carbon atom which bears a saturated or heterocycle of formula A1 A2 or A3 preferably such as a pyrrolidine ring a saturated heterocycle of formula A1 or A2 or Ra denotes a hydrogen atom and Rb represents a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from at least one of the ring members of said heterocycloalkyl radical denotes a ketone or Ra denotes a hydrogen atom and Rb represents a glucopyran radical of formula in which Re and which are identical or a hydroxyl the alkyl part of which may be optionally especially with one or more hydroxyl or an NR1R2 with R1 and which are identical or chosen from a hydrogen and it being understood that one of the radicals Re and Rf represents a covalent bond with the nitrogen atom of the NRaRb the configuration of said compounds of formula being D or preferably and of a or b anomeric The cosmetic use as claimed in any one of claims 1 to characterized in that said compound of formula is chosen from the compounds T to and to defined and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and the racemates alone or in a The cosmetic use as claimed in any one of claims 1 to characterized in that said compound of formula is chosen from the compounds to and to as defined in claim 6 and the compounds 1 to 4 as defined and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and the racemates alone or in a The compounds of formula as defined in any one of claims 1 to with the exception of compounds Cp1 to Cp5 and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a The compounds as claimed in claim chosen from the compounds of formula in R is as defined in any one of claims 1 to 5 for the compounds of formula Sub denotes a group such as and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a The compounds as claimed in claim chosen from the compounds of formula in denotes a radical or a said alkyl group being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from alkoxy at least one of the ring members of said denoting a ketone optionally substituted especially with one or more identical or different radicals chosen from C4 said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as a said alkenyl radical being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as an optionally substituted aryl or heteroaryl Ta represents a radical chosen a hydrogen a said alkyl group being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as a said alkenyl group being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with Rs representing a hydrogen atom or a group such as an aryl or heteroaryl optionally substituted especially with one or more identical or different radicals chosen from such as a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from C4 alkoxy at least one of the ring members of said heterocycloalkyl radical denoting a ketone Tb represents a radical chosen a hydrogen a said alkyl group being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from said alkyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as a said alkenyl group being optionally substituted especially with one or more identical or different radicals chosen optionally substituted especially with one or more identical or different radicals chosen from said alkenyl radical being optionally interrupted with one or more heteroatoms such as S and with representing a hydrogen atom or a group such as an aryl or heteroaryl optionally substituted especially with one or more identical or different radicals chosen from such as a heterocycloalkyl optionally substituted especially with one or more identical or different radicals chosen from C4 alkoxy at least one of the ring members of said heterocycloalkyl radical denoting a ketone or else Ta and Tb together with the nitrogen atom to which they are an optionally substituted such as piperidino or and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a The compounds as claimed in any one of claims 8 to chosen from the compounds to and to defined and also the salts the solvates thereof and including enantiomers and and the racemates alone or in a and in particular the R isomers of the carbon in position 4 of the dithiazocane ring of said compounds to and to The cosmetic use as claimed in one of the preceding claims characterized in that said compounds of formula are chosen and also the salts the solvates thereof and the optical geometrical isomers including enantiomers and and the racemates alone or in a A preferably a cosmetic preferably intended for topical in a physiologically acceptable a compound of formula as claimed in any one of the preceding The preferably cosmetic as claimed in the preceding characterized in that the compound is present at an amount of between and by preferably between and by weight and preferentially from to by relative to the total weight of the The preferably cosmetic as claimed in either of claims 13 and characterized in that it comprises at least one adjuvant chosen from the group formed by organic especially especially oils and silicone cosmetic active organic or mineral photoprotective odor A cosmetic process for lightening bleaching keratin comprising the application of at least one compound of formula as defined in any one of claims 1 to 12 or of a composition containing same according to a composition as claimed in any one of claims 13 to The process as claimed in the preceding for lightening bleaching the insufficientOCRQuality