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Dual Specificity Antibodies And Methods Of Making And Using
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for il-1 alpha and il-1 beta and neutralize il-1 alpha and il-1 beta activity in vitroand in vivo. An antibody of the invention can be full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies if the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., il-1 alpha and il-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which il-1 alpha and/or il-1 beta activity is detrimental.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
21 September 2007
Publication Number
26/2009
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application
Applicants
Abbott Laboratories,
OF 100 ABBOTT PARK ROAD, ABBOTT PARK, IL 60064,
Inventors
1. COLLINSON Albert
of 21 Overlook Drive Marlborough MA 01752 USA.
2. GHAYUR Tariq
of 1014 Washington Street Holliston MA 01746 USA.
3. AVGERINOS George
of 15 Hammond Circle Sudbury MA 10776 USA.
4. DIXON Richard
of 6 Samuel Drive North Grafton MA 01536 USA.
5. KAYMAKCALAN Zehra
of 4 Piccadilly Way Westborough MA 01581 USA.
Specification
As Attached
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 1500-mumnp-2007-abstract(21-9-2007).pdf | 2018-08-09 |
| 1 | 1500-MUMNP-2007-CORRESPONDENCE(23-10-2012).pdf | 2012-10-23 |
| 2 | 1500-MUMNP-2007 -MUM-REPLY TO HEARING(14-12-2012).pdf | 2012-12-14 |
| 2 | 1500-MUMNP-2007-ASSIGNMENT(1-10-2013).pdf | 2018-08-09 |
| 3 | 1500-mumnp-2007-assignment(4-4-2008).pdf | 2018-08-09 |
| 3 | 1500-MUMNP-2007 -MUM-MARKED COPY(14-12-2012).pdf | 2012-12-14 |
| 4 | 1500-MUMNP-2007-AUSTRALIAN DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 4 | 1500-MUMNP-2007 -MUM-FORM 13(14-12-2012).pdf | 2012-12-14 |
| 5 | 1500-MUMNP-2007-BRAZILLIA DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 5 | 1500-MUMNP-2007 -MUM-CLAIMS(AMENDED)-(14-12-2012).pdf | 2012-12-14 |
| 6 | Form-5.doc | 2018-08-09 |
| 6 | 1500-MUMNP-2007-BULGARIAN DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 7 | 1500-MUMNP-2007-CANADA DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 8 | Form-1.pdf | 2018-08-09 |
| 8 | 1500-MUMNP-2007-CHINA DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 9 | 1500-mumnp-2007-claims(21-9-2007).pdf | 2018-08-09 |
| 9 | 1500-MUMNP-2007_EXAMREPORT.pdf | 2018-08-09 |
| 10 | 1500-MUMNP-2007-CLAIMS(AMENDED)-(8-6-2012).pdf | 2018-08-09 |
| 10 | 1500-MUMNP-2007-US DOCUMENT(8-6-2012).pdf | 2018-08-09 |
| 11 | 1500-MUMNP-2007-CLAIMS(MARKED COPY)-(8-6-2012).pdf | 2018-08-09 |
| 11 | 1500-MUMNP-2007-US DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 12 | 1500-MUMNP-2007-CORRESPONDENCE(1-10-2013).pdf | 2018-08-09 |
| 12 | 1500-MUMNP-2007-TAIWAN DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 13 | 1500-MUMNP-2007-CORRESPONDENCE(16-6-2010).pdf | 2018-08-09 |
| 13 | 1500-mumnp-2007-sequence listing(21-9-2007).pdf | 2018-08-09 |
| 14 | 1500-MUMNP-2007-CORRESPONDENCE(24-8-2012)-.pdf | 2018-08-09 |
| 14 | 1500-MUMNP-2007-REPLY TO EXAMINATION REPORT(8-6-2012).pdf | 2018-08-09 |
| 15 | 1500-MUMNP-2007-CORRESPONDENCE(24-8-2012).pdf | 2018-08-09 |
| 15 | 1500-MUMNP-2007-POLISH DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 16 | 1500-MUMNP-2007-NEW ZEALAND DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 16 | 1500-mumnp-2007-correspondence(4-4-2008).pdf | 2018-08-09 |
| 17 | 1500-MUMNP-2007-MEXICAN DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 17 | 1500-MUMNP-2007-CORRESPONDENCE(7-12-2011).pdf | 2018-08-09 |
| 18 | 1500-MUMNP-2007-CORRESPONDENCE(8-8-2012).pdf | 2018-08-09 |
| 18 | 1500-MUMNP-2007-KOREA DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 19 | 1500-MUMNP-2007-CORRESPONDENCE(IPO)-(FER)-(10-6-2011).pdf | 2018-08-09 |
| 19 | 1500-MUMNP-2007-JAPANESE DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 20 | 1500-MUMNP-2007-CORRESPONDENCE(IPO)-(HEARING NOTICE)-(25-4-2016).pdf | 2018-08-09 |
| 20 | 1500-MUMNP-2007-ISRAEL DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 21 | 1500-MUMNP-2007-CORRESPONDENCE(IPO)-(HEARING NOTICE)-(26-7-2012).pdf | 2018-08-09 |
| 21 | 1500-MUMNP-2007-GENERAL POWER OF ATTORNEY(8-6-2012).pdf | 2018-08-09 |
| 22 | 1500-MUMNP-2007-CORRESPONDENCE(IPO)-(ORDER)-(16-9-2016).pdf | 2018-08-09 |
| 22 | 1500-MUMNP-2007-GENERAL POWER OF ATTORNEY(1-10-2013).pdf | 2018-08-09 |
| 23 | 1500-mumnp-2007-description(complete)-(21-9-2007).pdf | 2018-08-09 |
| 23 | 1500-MUMNP-2007-FORM 6(1-10-2013).pdf | 2018-08-09 |
| 24 | 1500-MUMNP-2007-EP DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 24 | 1500-mumnp-2007-form 5(21-9-2007).pdf | 2018-08-09 |
| 25 | 1500-MUMNP-2007-EP DOCUMENT(8-6-2012).pdf | 2018-08-09 |
| 25 | 1500-MUMNP-2007-FORM 3(7-12-2011).pdf | 2018-08-09 |
| 26 | 1500-MUMNP-2007-FORM 1(1-10-2013).pdf | 2018-08-09 |
| 26 | 1500-mumnp-2007-form 3(4-4-2008).pdf | 2018-08-09 |
| 27 | 1500-mumnp-2007-form 1(21-9-2007).pdf | 2018-08-09 |
| 27 | 1500-mumnp-2007-form 3(4-2-2008).pdf | 2018-08-09 |
| 28 | 1500-MUMNP-2007-FORM 13(8-6-2012).pdf | 2018-08-09 |
| 28 | 1500-MUMNP-2007-FORM 3(24-8-2012).pdf | 2018-08-09 |
| 29 | 1500-mumnp-2007-form 3(21-9-2007).pdf | 2018-08-09 |
| 29 | 1500-mumnp-2007-form 18(28-9-2007).pdf | 2018-08-09 |
| 30 | 1500-mumnp-2007-form 2(21-9-2007).pdf | 2018-08-09 |
| 30 | 1500-MUMNP-2007-FORM 3(16-6-2010).pdf | 2018-08-09 |
| 31 | 1500-MUMNP-2007-FORM 2(TITLE PAGE)-(1-10-2013).pdf | 2018-08-09 |
| 31 | 1500-mumnp-2007-form 2(title page)-(21-9-2007).pdf | 2018-08-09 |
| 32 | 1500-MUMNP-2007-FORM 2(TITLE PAGE)-(1-10-2013).pdf | 2018-08-09 |
| 32 | 1500-mumnp-2007-form 2(title page)-(21-9-2007).pdf | 2018-08-09 |
| 33 | 1500-mumnp-2007-form 2(21-9-2007).pdf | 2018-08-09 |
| 33 | 1500-MUMNP-2007-FORM 3(16-6-2010).pdf | 2018-08-09 |
| 34 | 1500-mumnp-2007-form 3(21-9-2007).pdf | 2018-08-09 |
| 34 | 1500-mumnp-2007-form 18(28-9-2007).pdf | 2018-08-09 |
| 35 | 1500-MUMNP-2007-FORM 13(8-6-2012).pdf | 2018-08-09 |
| 35 | 1500-MUMNP-2007-FORM 3(24-8-2012).pdf | 2018-08-09 |
| 36 | 1500-mumnp-2007-form 1(21-9-2007).pdf | 2018-08-09 |
| 36 | 1500-mumnp-2007-form 3(4-2-2008).pdf | 2018-08-09 |
| 37 | 1500-MUMNP-2007-FORM 1(1-10-2013).pdf | 2018-08-09 |
| 37 | 1500-mumnp-2007-form 3(4-4-2008).pdf | 2018-08-09 |
| 38 | 1500-MUMNP-2007-EP DOCUMENT(8-6-2012).pdf | 2018-08-09 |
| 38 | 1500-MUMNP-2007-FORM 3(7-12-2011).pdf | 2018-08-09 |
| 39 | 1500-mumnp-2007-form 5(21-9-2007).pdf | 2018-08-09 |
| 39 | 1500-MUMNP-2007-EP DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 40 | 1500-mumnp-2007-description(complete)-(21-9-2007).pdf | 2018-08-09 |
| 40 | 1500-MUMNP-2007-FORM 6(1-10-2013).pdf | 2018-08-09 |
| 41 | 1500-MUMNP-2007-CORRESPONDENCE(IPO)-(ORDER)-(16-9-2016).pdf | 2018-08-09 |
| 41 | 1500-MUMNP-2007-GENERAL POWER OF ATTORNEY(1-10-2013).pdf | 2018-08-09 |
| 42 | 1500-MUMNP-2007-CORRESPONDENCE(IPO)-(HEARING NOTICE)-(26-7-2012).pdf | 2018-08-09 |
| 42 | 1500-MUMNP-2007-GENERAL POWER OF ATTORNEY(8-6-2012).pdf | 2018-08-09 |
| 43 | 1500-MUMNP-2007-CORRESPONDENCE(IPO)-(HEARING NOTICE)-(25-4-2016).pdf | 2018-08-09 |
| 43 | 1500-MUMNP-2007-ISRAEL DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 44 | 1500-MUMNP-2007-CORRESPONDENCE(IPO)-(FER)-(10-6-2011).pdf | 2018-08-09 |
| 44 | 1500-MUMNP-2007-JAPANESE DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 45 | 1500-MUMNP-2007-CORRESPONDENCE(8-8-2012).pdf | 2018-08-09 |
| 45 | 1500-MUMNP-2007-KOREA DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 46 | 1500-MUMNP-2007-CORRESPONDENCE(7-12-2011).pdf | 2018-08-09 |
| 46 | 1500-MUMNP-2007-MEXICAN DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 47 | 1500-MUMNP-2007-NEW ZEALAND DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 47 | 1500-mumnp-2007-correspondence(4-4-2008).pdf | 2018-08-09 |
| 48 | 1500-MUMNP-2007-CORRESPONDENCE(24-8-2012).pdf | 2018-08-09 |
| 48 | 1500-MUMNP-2007-POLISH DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 49 | 1500-MUMNP-2007-CORRESPONDENCE(24-8-2012)-.pdf | 2018-08-09 |
| 49 | 1500-MUMNP-2007-REPLY TO EXAMINATION REPORT(8-6-2012).pdf | 2018-08-09 |
| 50 | 1500-MUMNP-2007-CORRESPONDENCE(16-6-2010).pdf | 2018-08-09 |
| 50 | 1500-mumnp-2007-sequence listing(21-9-2007).pdf | 2018-08-09 |
| 51 | 1500-MUMNP-2007-CORRESPONDENCE(1-10-2013).pdf | 2018-08-09 |
| 51 | 1500-MUMNP-2007-TAIWAN DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 52 | 1500-MUMNP-2007-CLAIMS(MARKED COPY)-(8-6-2012).pdf | 2018-08-09 |
| 52 | 1500-MUMNP-2007-US DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 53 | 1500-MUMNP-2007-CLAIMS(AMENDED)-(8-6-2012).pdf | 2018-08-09 |
| 53 | 1500-MUMNP-2007-US DOCUMENT(8-6-2012).pdf | 2018-08-09 |
| 54 | 1500-mumnp-2007-claims(21-9-2007).pdf | 2018-08-09 |
| 54 | 1500-MUMNP-2007_EXAMREPORT.pdf | 2018-08-09 |
| 55 | Form-1.pdf | 2018-08-09 |
| 55 | 1500-MUMNP-2007-CHINA DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 56 | 1500-MUMNP-2007-CANADA DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 57 | 1500-MUMNP-2007-BULGARIAN DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 58 | 1500-MUMNP-2007-BRAZILLIA DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 58 | 1500-MUMNP-2007 -MUM-CLAIMS(AMENDED)-(14-12-2012).pdf | 2012-12-14 |
| 59 | 1500-MUMNP-2007-AUSTRALIAN DOCUMENT(7-12-2011).pdf | 2018-08-09 |
| 59 | 1500-MUMNP-2007 -MUM-FORM 13(14-12-2012).pdf | 2012-12-14 |
| 60 | 1500-MUMNP-2007 -MUM-MARKED COPY(14-12-2012).pdf | 2012-12-14 |
| 60 | 1500-mumnp-2007-assignment(4-4-2008).pdf | 2018-08-09 |
| 61 | 1500-MUMNP-2007 -MUM-REPLY TO HEARING(14-12-2012).pdf | 2012-12-14 |
| 61 | 1500-MUMNP-2007-ASSIGNMENT(1-10-2013).pdf | 2018-08-09 |
| 62 | 1500-mumnp-2007-abstract(21-9-2007).pdf | 2018-08-09 |
| 62 | 1500-MUMNP-2007-CORRESPONDENCE(23-10-2012).pdf | 2012-10-23 |