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Effervescent Formulations Of Florfenicol For Addition In Drinking Water Systems

Abstract: Abstract EFFERVESCENT FORMULATIONS OF FLORFENICOL FOR ADDITION IN DRINKING WATER SYSTEMS The invention relates to an effervescent formulation containing florfenicol or an antibiotic of related structure. When introduced into water, the effervescent formulation s dissolved with minimal or no agitation and provides a solution or a homogeneous dispersion of florfenicol. The formulations are typically in the form of free flowing powders, granules or tablets. The effervescent formulations are useful for the treatment of bacterial infections and allow for the rapid dispersion and dissolution of florfenicol in the drinking water systems of an animal in need of such treatment.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
18 June 2009
Publication Number
36/2016
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application

Applicants

SCHERING-PLOUGH LTD.,
WEYSTRASSE 20, PO BOX, CH-6000 LUCERNE 6,

Inventors

1. TONGIANI, SERENA,
29/B SPRINGFIELD AVENUE, NEW JERSEY 07016,
2. FREEHAUF, KEITH
24, READING ROAD, STOCKTON, NEW JERSEY 08559,

Specification

EFFERVESCENT FORMULATIONS OF FLORFENICOL FOR ADDITION IN DRINKING WATER SYSTEMS Field of the Invention: The present invention relates to an effervescent pharmaceutical composition of florfenicol (FFC), and antibiotics of related structure in the form of blend powder, granules or tablets. The composition is providing a rapidly solubilizing additive for addition to drinking water systems for the treatment of bacterial infections in animals. Background of Invention: Florfenicol is a broad spectrum antibiotic, structurally related to thiomphenicol and chloramphenicol, which has been developed as a veterinary treatment for use in animals, particularly cattle, swine, poultry, and fish. Florfenicol is indicated for the control of mortality due to E. coli airsacculitis in broiler chickens, aRd for treatment and control of swine respiratory diseases associated with Actinobacillus pleuropneumoniae, P. multocida, Mycoplasma, Salmonella cholera suis and Streptococcus suis Type il. Currently veterinary products containing florfenicol are available in the form of injectable (for treatment of cattle respiratory diseases) powder or granules (addition to feed in aquaculture) and as concentrate nonaqueous organic solution (for addition in swine and poultry drinking water systems). The effervescent product designed for addition to drinking water systems has significant appeal to the industry because of its ease of administration. One currently marketed product is Nuflor® Concentrate Solution (Schering-Plough). Nuflor® Concentrate Solution uses a high content of organic solvent to provide an immediate solubilization of florfenicol in water and can be used not only in the bulk water source, at the efficacious concentration of 400 mg/gal (-0.1 mg/mL), but also with an automated proportioner mixing tank system (mixing ratio of 1 oz. to 1 gallon) at a concentration of -13.5 mg/mL. There are, however, some drawbacl

Documents

Application Documents

# Name Date
1 3503-CHENP-2009 CORRESPONDENCE OTHERS 17-12-2009.pdf 2009-12-17
1 3503-CHENP-2009-AbandonedLetter.pdf 2017-07-19
2 3503-CHENP-2009-FER.pdf 2016-10-24
2 3503-CHENP-2009 FORM-18 18-12-2009.pdf 2009-12-18
3 3503-chenp-2009 description(complete).pdf 2011-09-04
3 3503-chenp-2009 abstract.pdf 2011-09-04
4 3503-chenp-2009 corrspondence others.pdf 2011-09-04
4 3503-chenp-2009 claims.pdf 2011-09-04
5 3503-chenp-2009 pct.pdf 2011-09-04
5 3503-chenp-2009 form-1.pdf 2011-09-04
6 3503-chenp-2009 form-5.pdf 2011-09-04
6 3503-chenp-2009 form-26.pdf 2011-09-04
7 3503-chenp-2009 form-3.pdf 2011-09-04
8 3503-chenp-2009 form-5.pdf 2011-09-04
8 3503-chenp-2009 form-26.pdf 2011-09-04
9 3503-chenp-2009 pct.pdf 2011-09-04
9 3503-chenp-2009 form-1.pdf 2011-09-04
10 3503-chenp-2009 corrspondence others.pdf 2011-09-04
10 3503-chenp-2009 claims.pdf 2011-09-04
11 3503-chenp-2009 abstract.pdf 2011-09-04
11 3503-chenp-2009 description(complete).pdf 2011-09-04
12 3503-CHENP-2009-FER.pdf 2016-10-24
12 3503-CHENP-2009 FORM-18 18-12-2009.pdf 2009-12-18
13 3503-CHENP-2009-AbandonedLetter.pdf 2017-07-19
13 3503-CHENP-2009 CORRESPONDENCE OTHERS 17-12-2009.pdf 2009-12-17

Search Strategy

1 3503CHENP2009SEARCH_30-09-2016.pdf