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Fatty Acid Derivative Labeled By Positron Emitting Nuclide
Abstract: [Problem] To provide a labeled fatty acid derivative for diagnostic imaging that enables the quantification of myocardial fatty acid metabolic activity. [Solution] The inventors, engaging in diligent research into methods that enable the quantification of fatty acid metabolic activity, discovered that a labeled fatty acid derivative represented by formula (I), in which [18F] has been substituted at a specific position of a long-chain carboxylic acid compound containing a sulfur atom, or a salt thereof, has good accumulation in the myocardium, and enables imaging of fatty acid metabolic activity via positron emission tomography (PET). Therefore, the labeled fatty acid derivative according to the present invention can be used as a radiotracer for swift and noninvasive quantification of myocardial fatty acid metabolic activity, diagnostic imaging of heart diseases such as ischemic heart disease, diagnostic imaging of the therapeutic effects yielded by a heart disease therapeutic agent, and so forth.
Notices, Deadlines & Correspondence
Patent Information
Applicants
ASTELLAS PHARMA INC.
Inventors
1. MURAKAMI, Yoshihiro
2. FUSHIKI, Hiroshi
3. YONEZAWA, Koichi
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202247040884-CLAIMS [28-03-2025(online)].pdf | 2025-03-28 |
| 1 | 202247040884-FORM 3 [28-10-2024(online)]-1.pdf | 2024-10-28 |
| 1 | 202247040884.pdf | 2022-07-18 |
| 2 | 202247040884-FER_SER_REPLY [28-03-2025(online)].pdf | 2025-03-28 |
| 2 | 202247040884-FORM 3 [28-10-2024(online)].pdf | 2024-10-28 |
| 2 | 202247040884-STATEMENT OF UNDERTAKING (FORM 3) [18-07-2022(online)].pdf | 2022-07-18 |
| 3 | 202247040884-FER.pdf | 2024-10-04 |
| 3 | 202247040884-OTHERS [28-03-2025(online)].pdf | 2025-03-28 |
| 3 | 202247040884-PROOF OF RIGHT [18-07-2022(online)].pdf | 2022-07-18 |
| 4 | 202247040884-PRIORITY DOCUMENTS [18-07-2022(online)].pdf | 2022-07-18 |
| 4 | 202247040884-FORM 3 [28-10-2024(online)]-1.pdf | 2024-10-28 |
| 4 | 202247040884-FORM 18 [20-10-2023(online)].pdf | 2023-10-20 |
| 5 | 202247040884-FORM 3 [28-10-2024(online)].pdf | 2024-10-28 |
| 5 | 202247040884-FORM 1 [18-07-2022(online)].pdf | 2022-07-18 |
| 5 | 202247040884-Correspondence_Form 1 And Form 26_12-01-2023.pdf | 2023-01-12 |
| 6 | 202247040884-FORM 3 [15-12-2022(online)].pdf | 2022-12-15 |
| 6 | 202247040884-FER.pdf | 2024-10-04 |
| 6 | 202247040884-DRAWINGS [18-07-2022(online)].pdf | 2022-07-18 |
| 7 | 202247040884-FORM-26 [07-10-2022(online)].pdf | 2022-10-07 |
| 7 | 202247040884-FORM 18 [20-10-2023(online)].pdf | 2023-10-20 |
| 7 | 202247040884-DECLARATION OF INVENTORSHIP (FORM 5) [18-07-2022(online)].pdf | 2022-07-18 |
| 8 | 202247040884-COMPLETE SPECIFICATION [18-07-2022(online)].pdf | 2022-07-18 |
| 8 | 202247040884-Correspondence_Form 1 And Form 26_12-01-2023.pdf | 2023-01-12 |
| 9 | 202247040884-DECLARATION OF INVENTORSHIP (FORM 5) [18-07-2022(online)].pdf | 2022-07-18 |
| 9 | 202247040884-FORM 3 [15-12-2022(online)].pdf | 2022-12-15 |
| 9 | 202247040884-FORM-26 [07-10-2022(online)].pdf | 2022-10-07 |
| 10 | 202247040884-DRAWINGS [18-07-2022(online)].pdf | 2022-07-18 |
| 10 | 202247040884-FORM 3 [15-12-2022(online)].pdf | 2022-12-15 |
| 10 | 202247040884-FORM-26 [07-10-2022(online)].pdf | 2022-10-07 |
| 11 | 202247040884-COMPLETE SPECIFICATION [18-07-2022(online)].pdf | 2022-07-18 |
| 11 | 202247040884-Correspondence_Form 1 And Form 26_12-01-2023.pdf | 2023-01-12 |
| 11 | 202247040884-FORM 1 [18-07-2022(online)].pdf | 2022-07-18 |
| 12 | 202247040884-DECLARATION OF INVENTORSHIP (FORM 5) [18-07-2022(online)].pdf | 2022-07-18 |
| 12 | 202247040884-FORM 18 [20-10-2023(online)].pdf | 2023-10-20 |
| 12 | 202247040884-PRIORITY DOCUMENTS [18-07-2022(online)].pdf | 2022-07-18 |
| 13 | 202247040884-DRAWINGS [18-07-2022(online)].pdf | 2022-07-18 |
| 13 | 202247040884-FER.pdf | 2024-10-04 |
| 13 | 202247040884-PROOF OF RIGHT [18-07-2022(online)].pdf | 2022-07-18 |
| 14 | 202247040884-FORM 1 [18-07-2022(online)].pdf | 2022-07-18 |
| 14 | 202247040884-FORM 3 [28-10-2024(online)].pdf | 2024-10-28 |
| 14 | 202247040884-STATEMENT OF UNDERTAKING (FORM 3) [18-07-2022(online)].pdf | 2022-07-18 |
| 15 | 202247040884-FORM 3 [28-10-2024(online)]-1.pdf | 2024-10-28 |
| 15 | 202247040884-PRIORITY DOCUMENTS [18-07-2022(online)].pdf | 2022-07-18 |
| 15 | 202247040884.pdf | 2022-07-18 |
| 16 | 202247040884-OTHERS [28-03-2025(online)].pdf | 2025-03-28 |
| 16 | 202247040884-PROOF OF RIGHT [18-07-2022(online)].pdf | 2022-07-18 |
| 17 | 202247040884-FER_SER_REPLY [28-03-2025(online)].pdf | 2025-03-28 |
| 17 | 202247040884-STATEMENT OF UNDERTAKING (FORM 3) [18-07-2022(online)].pdf | 2022-07-18 |
| 18 | 202247040884-CLAIMS [28-03-2025(online)].pdf | 2025-03-28 |
| 18 | 202247040884.pdf | 2022-07-18 |
| 19 | 202247040884-US(14)-HearingNotice-(HearingDate-15-09-2025).pdf | 2025-08-14 |
| 20 | 202247040884-Correspondence to notify the Controller [08-09-2025(online)].pdf | 2025-09-08 |
Search Strategy
| 1 | Search_202247040884E_03-10-2024.pdf |