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Fatty Acid Derivative Labeled With Positron Emitting Radionuclide
Abstract: [Problem] To provide a labeled fatty acid derivative for imaging diagnosis that enables quantification of fatty acid metabolic activity in the heart muscle. [Solution] As the results of intensive studies on a method enabling quantification of fatty acid metabolic activity, the present inventors found that a labeled fatty acid derivative typified by 3-{[(5Z)-3-[18F]fluorotetradeca-5-en-1-yl]sulfanyl}propanoic acid or a salt thereof well accumulates in the heart muscle and thus enables imaging of fatty acid metabolic activity by positron emission tomography (PET). Thus, the labeled fatty acid derivative according to the present invention is usable as a radiolabeled tracer for quick and non-invasive quantification of fatty acid metabolic activity in the heart muscle, imaging diagnosis of heart diseases typified by ischemic heart disease, imaging diagnosis of the therapeutic effect of a therapeutic drug for a heart disease, etc.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
19 January 2021
Publication Number
05/2021
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
patent@depenning.com
Parent Application
Patent Number
Legal Status
Grant Date
2023-11-14
Renewal Date
Applicants
ASTELLAS PHARMA INC.
5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
Inventors
1. MURAKAMI, Yoshihiro
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
2. FUSHIKI, Hiroshi
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
3. FUJITA, Yuji
c/o Astellas Pharma Inc., 5-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
1038411
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202147002416-IntimationOfGrant14-11-2023.pdf | 2023-11-14 |
| 1 | 202147002416-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [19-01-2021(online)].pdf | 2021-01-19 |
| 2 | 202147002416-PatentCertificate14-11-2023.pdf | 2023-11-14 |
| 2 | 202147002416-STATEMENT OF UNDERTAKING (FORM 3) [19-01-2021(online)].pdf | 2021-01-19 |
| 3 | 202147002416-PRIORITY DOCUMENTS [19-01-2021(online)].pdf | 2021-01-19 |
| 3 | 202147002416-2. Marked Copy under Rule 14(2) [26-10-2023(online)].pdf | 2023-10-26 |
| 4 | 202147002416-FORM 3 [26-10-2023(online)].pdf | 2023-10-26 |
| 4 | 202147002416-FORM 1 [19-01-2021(online)].pdf | 2021-01-19 |
| 5 | 202147002416-Retyped Pages under Rule 14(1) [26-10-2023(online)].pdf | 2023-10-26 |
| 5 | 202147002416-DRAWINGS [19-01-2021(online)].pdf | 2021-01-19 |
| 6 | 202147002416-Written submissions and relevant documents [26-10-2023(online)].pdf | 2023-10-26 |
| 6 | 202147002416-DECLARATION OF INVENTORSHIP (FORM 5) [19-01-2021(online)].pdf | 2021-01-19 |
| 7 | 202147002416-Correspondence to notify the Controller [10-10-2023(online)].pdf | 2023-10-10 |
| 7 | 202147002416-COMPLETE SPECIFICATION [19-01-2021(online)].pdf | 2021-01-19 |
| 8 | 202147002416-FORM-26 [10-10-2023(online)].pdf | 2023-10-10 |
| 8 | 202147002416-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [19-01-2021(online)].pdf | 2021-01-19 |
| 9 | 202147002416-FORM-26 [16-02-2021(online)].pdf | 2021-02-16 |
| 9 | 202147002416-US(14)-HearingNotice-(HearingDate-13-10-2023).pdf | 2023-09-12 |
| 10 | 202147002416-ABSTRACT [11-04-2023(online)].pdf | 2023-04-11 |
| 10 | 202147002416-Proof of Right [03-03-2021(online)].pdf | 2021-03-03 |
| 11 | 202147002416-CLAIMS [11-04-2023(online)].pdf | 2023-04-11 |
| 11 | 202147002416-Correspondence_Form1_07-04-2021.pdf | 2021-04-07 |
| 12 | 202147002416-FER_SER_REPLY [11-04-2023(online)].pdf | 2023-04-11 |
| 12 | 202147002416-FORM 3 [14-06-2021(online)].pdf | 2021-06-14 |
| 13 | 202147002416-FORM 3 [11-04-2023(online)].pdf | 2023-04-11 |
| 13 | 202147002416.pdf | 2021-10-18 |
| 14 | 202147002416-FORM 18 [23-05-2022(online)].pdf | 2022-05-23 |
| 14 | 202147002416-OTHERS [11-04-2023(online)].pdf | 2023-04-11 |
| 15 | 202147002416-Correspondence_GPA_01-07-2022.pdf | 2022-07-01 |
| 15 | 202147002416-FER.pdf | 2022-10-19 |
| 16 | 202147002416-Correspondence_GPA_01-07-2022.pdf | 2022-07-01 |
| 16 | 202147002416-FER.pdf | 2022-10-19 |
| 17 | 202147002416-OTHERS [11-04-2023(online)].pdf | 2023-04-11 |
| 17 | 202147002416-FORM 18 [23-05-2022(online)].pdf | 2022-05-23 |
| 18 | 202147002416-FORM 3 [11-04-2023(online)].pdf | 2023-04-11 |
| 18 | 202147002416.pdf | 2021-10-18 |
| 19 | 202147002416-FER_SER_REPLY [11-04-2023(online)].pdf | 2023-04-11 |
| 19 | 202147002416-FORM 3 [14-06-2021(online)].pdf | 2021-06-14 |
| 20 | 202147002416-CLAIMS [11-04-2023(online)].pdf | 2023-04-11 |
| 20 | 202147002416-Correspondence_Form1_07-04-2021.pdf | 2021-04-07 |
| 21 | 202147002416-ABSTRACT [11-04-2023(online)].pdf | 2023-04-11 |
| 21 | 202147002416-Proof of Right [03-03-2021(online)].pdf | 2021-03-03 |
| 22 | 202147002416-FORM-26 [16-02-2021(online)].pdf | 2021-02-16 |
| 22 | 202147002416-US(14)-HearingNotice-(HearingDate-13-10-2023).pdf | 2023-09-12 |
| 23 | 202147002416-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [19-01-2021(online)].pdf | 2021-01-19 |
| 23 | 202147002416-FORM-26 [10-10-2023(online)].pdf | 2023-10-10 |
| 24 | 202147002416-Correspondence to notify the Controller [10-10-2023(online)].pdf | 2023-10-10 |
| 24 | 202147002416-COMPLETE SPECIFICATION [19-01-2021(online)].pdf | 2021-01-19 |
| 25 | 202147002416-Written submissions and relevant documents [26-10-2023(online)].pdf | 2023-10-26 |
| 25 | 202147002416-DECLARATION OF INVENTORSHIP (FORM 5) [19-01-2021(online)].pdf | 2021-01-19 |
| 26 | 202147002416-Retyped Pages under Rule 14(1) [26-10-2023(online)].pdf | 2023-10-26 |
| 26 | 202147002416-DRAWINGS [19-01-2021(online)].pdf | 2021-01-19 |
| 27 | 202147002416-FORM 3 [26-10-2023(online)].pdf | 2023-10-26 |
| 27 | 202147002416-FORM 1 [19-01-2021(online)].pdf | 2021-01-19 |
| 28 | 202147002416-PRIORITY DOCUMENTS [19-01-2021(online)].pdf | 2021-01-19 |
| 28 | 202147002416-2. Marked Copy under Rule 14(2) [26-10-2023(online)].pdf | 2023-10-26 |
| 29 | 202147002416-STATEMENT OF UNDERTAKING (FORM 3) [19-01-2021(online)].pdf | 2021-01-19 |
| 29 | 202147002416-PatentCertificate14-11-2023.pdf | 2023-11-14 |
| 30 | 202147002416-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [19-01-2021(online)].pdf | 2021-01-19 |
| 30 | 202147002416-IntimationOfGrant14-11-2023.pdf | 2023-11-14 |
Search Strategy
| 1 | SearchHistoryE_12-10-2022.pdf |