FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE
DERIVATIVES
Related Application Information
This application claims priority to U.S. Application No. 60/802.195 filed on May 19. 2006. the contents of which are herein incorporated by reference.
Technical Field
The invention relates to fused bicycloheterocyclc substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Description of Related Technology
Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central (CNS) and peripheral (PNS) nervous systems. Such receptors play an important role in regulating CNS function, particularly by modulating release of a wide range of neurotransmitters, including, but not necessarily limited to acetylcholine, norepinephrine, dopamine, serotonin and GABA. Consequently, nicotinic receptors mediate a very wide range of physiological effects, and have been targeted for therapeutic treatment of disorders relating to cognitive function, learning and memory, neurodegeneration. pain and inflammation, psychosis and sensory gating, mood and emotion, among others.
Many subtypes of the nAChR exist in the CNS and periphery. Each subtype has a different effect on regulating the overall physiological function. Typically, nAChRs are ion channels that are constructed from a pentameric assembly of subunit proteins. At least 12 subunit proteins, a2-al0 and β2-β4, have been identified in neuronal tissue. These subunits provide for a great variety of homomeric and heteromeric combinations that account for the diverse receptor subtypes. For example, the predominant receptor that is responsible for high affinity binding of nicotine in brain tissue has composition (a4)2{(β2)3 (the a4β2 subtype), while another major population of receptors is comprised of homomeric (a7)s (the a7 subtype) receptors.
Certain compounds, like the plant alkaloid nicotine, interact with all subtypes of
the nAChRs. accounting for the physiological effects of this compound. While nicotine
2

has been demonstrated to have many biological activities, not all of the effects mediated by nicotine aredesirable. For example, nicotine exerts gastrointestinal and cardiovascular side effects that interfere at therapeutic doses, and its addictive nature and acute toxicity are well-known. Ligands that arc selective for interaction with only certain subtypes of the nAChR offer potential for achieving beneficial therapeutic effects with an improved margin for safety.
The a7 and a4β2 nAChRs have been shown to play a significant role in enhancing cognitive function, including aspects of learning, memory and attention (Levin, E.D., J. Neurobiol. 53: 633-640, 2002). For example, a7 nAChRs have been linked to conditions and disorders related to attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, dementia associated with Lcwy bodies, dementia associated with Down's syndrome, AIDS dementia, Pick's Disease, as well as cognitive deficits associated with schizophrenia, among other systemic activities. The a4β2 receptor subtype is implicated in attention, cognition, schizophrenia, epilepsy, and pain control (Paterson and Norberg, Progress in Neurobiology 61 75-111, 2000).
The activity at both a7 and a4p2 nAChRs can be modified or regulated by the administration of subtype selective nAChR ligands. The ligands can exhibit antagonist, agonist, or partial agonist properties. Compounds that function as positive allosteric modulators are also known.
Although compounds that nonselectively demonstrate activity at a range of nicotinic receptor subtypes including the a4β2 and a? nAChRs are known, it would be beneficial to provide compounds that interact selectively with a7-containing neuronal nAChRs, a4p2 nAChRs, or both a7 and a4p2 nAChRs compared to other subtypes.
SUMMARY OF THE INVENTION
The invention is directed to fused bicycloheterocycle substituted azabicyclic compounds as well as compositions comprising such compounds, and method of using the same.
One aspect of the present invention is directed toward a compound of formula (I)


or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-0 ;
R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1is a 6-membered aryl or 6 mcmbered heteroaryl ring; Ar2 is a bicyclic heteroaryl; and
Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar' is

then L is O or S.
Another aspect of the invention relates to pharmaceutical compositions comprising compounds of the invention. Such compositions can be administered in accordance with a method of the invention, typically as part of a therapeutic regimen for treatment or prevention of conditions and disorders related to nAChR activity, and more particularly a7 nAChR activity.
Yet another aspect of the invention relates to a method of selectively modulating to nAChR activity, for example a7 nAChR activity. The method is useful for treating and/or preventing conditions and disorders related to a7 nAChR activity modulation in mammals. More particularly, the method is useful for conditions and disorders related to attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia. Pick's Disease, dementia associated with Lewy bodies, dementia associated with Down's syndrome, amyotrophic lateral sclerosis, Huntington's disease, diminished CNS function

associated with traumatic brain injury, acute pain, post-surgical pain, chronic pain, inflammatory pain, neuropathic pain, infertility, need for new blood vessel growth associated with wound healing, need for new blood vessel growth associated with vascularization of skin grafts, and lack of circulation, more particularly circulation around a vascular occlusion, among other systemic activities, for example inflammatory response mediated by TNF.
The compounds, compositions comprising the compounds, and methods for treating or preventing conditions and disorders by administering the compounds are further described herein.
DETAILED DESCRIPTION OF THE INVENTION
Definition of Terms
Certain terms as used in the specification are intended to refer to the following definitions, as detailed below.
The term "acyl", as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of acyl include, but are not limited to, acetyl, 1-oxopropyl, 2,2-dimethyl-1-oxopropyl, 1-oxobutyl, and 1-oxopentyl.
The term "acyloxy". as used herein, means an acyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom. Representative examples of acyloxy include, but are not limited to, acetyloxy. propionyloxy, and isobutyryloxy.
The term "alkenyl", as used herein, means a straight or branched chain hydrocarbon containing from 2 to 10 carbons and containing at least one carbon-carbon double bond formed by the removal of two hydrogens. Representative examples of alkenyl include, but are not limited to, ethenyl, 2-propenyl. 2-melhyl-2-propenyl. 3-butenyl. 4-penlenyl, 5-hexenyl, 2-heptenyl, 2-methyl-l-heptenyl, and 3-decenyl.
The term "alkoxy", as used herein, means an alkyl group as defined herein, appended to the parent molecular moiety through an oxygen atom. Representative examples of alkoxy include, but are not limited to, methoxy, ethoxy. propoxy, 2-propoxy, butoxy, tert-butoxy, pentyloxy, and hexyloxy.

The term "alkoxyalkoxy", as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through anolher alkoxy group, as defined herein. Representative examples of alkoxyalkoxy include, but are not limited to, tert-butoxymethoxy, 2-ethoxyethoxy, 2-mcthoxycthoxy, and methoxymethoxy.
The term "alkoxyalkyl", as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of alkoxyalkyl include, but are not limited to, tert-butoxymethyl, 2-ethoxycthyl, 2-methoxyethyl, and methoxymethyl.
The term "alkoxycarbonyl", as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through a carbonyl group, represented by -C(0)-, as defined herein. Representative examples of alkoxycarbonyl include, but are not limited to, methoxycarbonyl, ethoxycarbonyl, and tert-butoxycarbonyl.
The term "alkoxyimino", as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through an imino group, as defined herein. Representative examples of alkoxyimino include, but are not limited to, ethoxy(imino)methyl and methoxy(imino)methyl.
The term "alkoxysulfonyl", as used herein, means an alkoxy group, as defined herein, appended to the parent molecular moiety through a sulfonyl group, as defined herein. Representative examples of alkoxysulfonyl include, but are not limited to, niethoxysulfonyl, cthoxysulfonyl and propoxysulfonyl.
The term "alkyl", as used herein, means a straight or branched chain hydrocarbon containing from 1 to 6 carbon atoms. Representative examples of alkyl include, but are not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl. sec-butyl, iso-butyl, tert-butyl, n-pentyl, isopentyl, neopcntyl, and n-hexyl.
The term "alkylcarbonyl", as used herein, means an alkyl group, as defined herein, appended to the parent molecular - moiety through a carbonyl group, as defined herein. Representative examples of alkylcarbonyl include, but are not limited to, acetyl. 1-oxopropyl. 2.2-dimethyl-l-oxopropyl. 1-oxobutyl, and 1-oxopentyl.
The term "alkylcarbonyloxy", as used herein, means an alkylcarbonyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom. Representative examples of alkylcarbonyloxy include, but arc not limited to, acetyloxy. ethylcarbonyloxy, and tert-butylcarbonyloxy.

The term "alkylsulfonyl", as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a sulfonyl group, as defined herein. Representative examples of alkylsulfonyl include, but are not limited to, methylsulfonyl and ethylsulfonyl.
The term "alkylthio", as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a sulfur atom. Representative examples of alkylthio include, but are not limited, methylthio, ethylthio. tert-butylthio, and hcxylthio.
The term "alkynyl", as used herein, means a straight or branched chain hydrocarbon group containing from 2 to 10 carbon atoms and containing at least one carbon-carbon triple bond. Representative examples of alkynyl include, but arc not limited, to acetylenyl, 1-propynyl, 2-propynyl, 3-butynyl, 2-pentynyl, and 1-butynyl.
The term "amido", as used herein, means an amino, alkylamino, or dialkylamino group appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of amido include, but are not limited to, aminocarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, and ethylmethylaminocarbonyl.
The term "aryl", as used herein, means a monocyclic or bicyclic aromatic ring system. Representative examples of aryl include, but are not limited to, phenyl and naphthyl.
The aryl groups of this invention are substituted with 0, 1, 2, 3, 4, or 5 substituents independently selected from acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylsulfonyl, alkynyl, amino, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy, -NRgR,, (NRgRj)alkyl. (NRgR|)alkoxy. (NRgRj)cai-bonyl, and (NRgRi)sulfonyl, wherein Rg and R, are each independently selected from the group consisting of hydrogen and alkyl.
The term "arylcarbonyl", as used herein, means an aryl group, as defined herein, or a benzyl group appended lo the parent molecular moiety through a carbonyl gioup, represented by -C(0)-, as defined herein. Representative examples of arylcarbonyl include, but are not limited to, phenylcarbonyl and benzylcarbonyl.
The term "aryloxycarbonyl", as used herein, means an aryl-O- group, wherein the aryl of aryl-O- is as defined herein, or a benzyoxyl group appended to the parent

molecular moiety through a carbonyl group, represented by -C(0)-, as defined herein. Representative examples of aryloxycarbonyl include, but are not limited to, phenoxycarbonyl and benzyloxycarbonyl.
The term "arylsulfonyl", as used herein, means an aryl group, as defined herein, appended to the parent molecular moiety through a sulfonyl gioup, as defined herein. Representative examples of arylsulfonyl include, but arc not limited to, phenylsulfonyl, (mcthylaminophenyl)sulfonyl, (dimethylaminophenyl)sulfonyl, and (naphthyl)sulfonyl.
The term "carbonyl", as used herein, means a -C(0)- group.
The term "carboxy", as used herein, means a -CO2H group.
The term "cyano", as used herein, means a -CN group.
The term "formyl", as used herein, means a -C(0)H group.
The term "halo" or "halogen", as used herein, means -CI, -Br, -I or -F.
The term "haloalkoxy", as used herein, means at least one halogen, as defined herein, appended to the parent molecular moiety through an alkoxy group, as defined herein. Representative examples of haloalkoxy include, but are not limited to, chloromethoxy, 2-fluoroethoxy, trifluoromethoxy, and pentafluoroethoxy.
The term "haloalkyl", as used herein, means at least one halogen, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of haloalkyl include, but are not limited to, chloromethyl, 2-fluoroethyl, trifluoromethyl, pcntafluoroethyl, and 2-chloro-3-tluoropentyl.
The term "hcteroaryl" means an aromatic five- or six-membercd ring containing 1, 2, 3, or 4 heteroatoms independently selected from group consisting of nitrogen, oxygen and sulfur. The hcteroaryl groups arc connected to the parent molecular moiety through a carbon or nitrogen atom. Representative examples of hcteroaryl include, but are not limited to, furyl, imidazolyl. indazolyl, benzothiozolyl. isoxazolyl, isothiazolyl, oxadiazolyl, oxazolyl, pyrazinyl. pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl, tctrazolyl, thiadiazolyl, thiazolyl, thienyl. triazinyl, and triazolyl.
The hcteroaryl groups of the invention are substituted with 0, 1,2, or 3 substituents independently selected from alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycai-bonyl, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylcaibonyloxy, alkylsulfonyl, alkylthio, alkynyl, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy.

hydroxyalkyl, mercapto, nitro, -NRgR,, (NRgRj)alkyl, (NRgRj)alkoxy, (NRgRi)carbonyl, and (NRgRi)sulfonyl, wherein Rg and Rj, are each independently selected from the group consisting of hydrogen and alkyl.
The term "bicyclic heteroaryl" refers to fused aromatic nine- and ten-membercd bicyclic rings containing 1, 2, 3, or 4 hcteroatoms independently selected from the group conisisting of nitrogen, oxygen and sulfur. The bicyclic heteroaryl groups are connected to the parent molecular moiety through a carbon or nitrogen atom. Representative examples of bicyclic heteroai'yl rings include, but arc not limited to, indolyl, benzothiazolyl, benzofuranyl, isoquinolinyl, and quinolinyl. Bicyclic heteroaryl groups of the invention are substituted with 0, 1,2, or 3 substituents independently selected from alkcnyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfonyl, alkylthio, alkynyl, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, -NRgR,. (NRgRj)alkyl, (NRgRj)alkoxy, (NRgRj)carbonyl, and (NR„Rj)sulfonyl, wherein Rg and Rj are each independently selected from the group consisting of hydrogen and alkyl.
The term "heterocycle" or "heterocyclic" as used herein, means a monocyclic heterocycle or a bicyclic heterocycle. The monocyclic heterocycle is a 3, 4, 5, 6 or 7 membered ring containing at least one heteroatom independently selected from the group consisting of nitrogen, oxygen and sulfur. The 3 or 4 membered ring contains 1 heteroatom selected from the group consisting of nitrogen, oxygen and sulfur. The 5 membered ring contains zero or one double bond and one, two or three heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur. The 6 or 7 membered ring contains zero, one or two double bonds and one, two or three heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur. The monocyclic heterocyclc is connected to the parent molecular moiety through any carbon atom or any nitrogen atom contained within the monocyclic heterocycle. Representative examples of monocyclic heterocycle include, but are not limited to, azetidinyl, azepanyl, aziridinyl, diazepanyl, 1,3-dioxanyl, 1,3-dioxolanyl, 1.3-dithiolanyl, 1,3-dithianyl, imidazolinyl. imidazolidinyl, isothiazolinyl, isothiazolidinyl, isoxazolinyl, isoxazolidinyl, morpholinyl, oxadiazolinyl, oxadiazolidinyl, oxazolinyl, oxazolidinyl, piperazinyl, piperidinyl, pyranyl, pyrazolinyl, pyrazolidinyl, pyrrolinyl, pyrrolidinyl, tetrahydrofuranyl. tetrahydrothienyl, thiadiazolinyl, thiadiazolidinyl, thiazolinyl, thiazolidinyl, thiomorpholinyl, 1,1-

dioxidothiomorpholinyl (thiomorpholine sulfone), thiopyranyl, and trithianyl. The bicyclic hcterocycle is a monocyclic hcterocyclc that is either fused to a cycloalkyl ring, a heteroaryl ring or another heterocyclic ring, or is formed by an alkyl chain attached to two non-adjacent carbons contained within the monocyclic heterocyclic ring. The bicyclic hcterocycle is connected to the parent molecular moiety through any carbon atom or any nitrogen atom contained within the monocyclic hcterocycle. Representative examples of bicyclic hcterocycle include, but are not limited lo, azabicyclo|3.1.1|heptane, azabicyclo|3.2.1]octanc, 1,3-benzodioxolyl, 1,3-bcnzodithiolyl, 2,3-dihydro-l,4-benzodioxinyl, 2,3-dihydro-l-benzofuranyl, 2,3-dihydro-l-benzothienyl, 2,3-dihydro-IH-indolyl, and 1,2,3,4-tetrahydroquinolinyl.
The heterocyclic groups of the invention are substituted with 0, 1,2, or 3 substituents independently selected from alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxysulfonyl alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfonyl, alkylthio, alkynyl, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, -NRgRj, (NRgRi)alkyl, (NRgRj)alkoxy, (NRgRj)carbonyl, and (NRgRj)sulfonyl, wherein Rg and R, are each independently selected from the group consisting of hydrogen and alkyl.
The term "hydroxy", as used herein, means an -OH group.
The term "hydroxyalkyl", as used herein, means at least one hydroxy group, as defined herein, is appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of hydroxyalkyl include, but are not limited to, hydroxymethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2,3-dihydroxypentyl, and 2-ethyl-4-hydroxyheptyl.
The term "mercapto". as used herein, means a -SH gioup.
The term "nitro", as used herein, means a -NO2 group.
The term "-NRgRj", as used herein, means two groups, Rg and R,, which are appended to the parent molecular moiety through a nitrogen atom. Rg and Rj are each independently hydrogen or alkyl. Representative examples of-NRgR, include, but arc not limited to, amino, mcthylamino, dimethylamino, and mcthylethylamino.
The term "(NRgRj)alkyl", as used herein, means a - NRgRj group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of (NRgRj)alkyl include, but are not limited to.

(amino)methyl, (dimethylamino)methyl, and (ethylamino)methyl.
The term "(NRgRj)alkoxy", as used herein, means a - NRgR, group, as defined herein, appended to the parent molecular moiety through an alkoxy group, as defined herein. Representative examples of (NRgRi)alkoxy include, but are not limited to, (amino)melhoxy, (dimethylamino)methoxy. and (diethylamino)ethoxy.
The term "(NRgRi)carbonyl", as used herein, means a - NRgR, group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein. Representative examples of (NRgRj)carbonyl include, but are not limited to, aminocarbonyl. (methylamino)carbonyl, (dimethylamino)carbonyl, and (ethyl methyl am i no )c arbonyl.
The term "(NRgRi)sulfonyl", as used herein, means a -NRgR, group, as defined herein, appended to the parent moleculai' moiety through a sulfonyl group, as defined herein. Representative examples of (NRgRi)sulfonyl include, but are not limited to, aminosulfonyl, (methylamino)sulfonyl, (dimethylamino)sulfonyl, and (ethylmethylamino)sulfonyl.
The term "sulfonyl", as used herein, means a -S(0):- group.
The term "thioalkoxy", as used herein, means an alkyl group, as defined herein, appended to the parent molecular moiety through a sulfur atom. Representative examples of thioalkoxy include, but are no limited to, methylthio, ethylthio, and propylthio.
Although typically it may be recognized that an asterisk is used to indicate that the exact subunit composition of a receptor is uncertain, for example a3b4* indicates a receptor that contains the a3 and P4 proteins in combination with other subunits, the term cx7 as used herein is intended to include receptors wherein the exact subunit composition is both certain and uncertain. For example, as used herein a7 includes homomeric (a7)5 receptors and a7* receptors, which denote a nAChR containing at least one a7 subunit.
Compounds of the invention
Compounds of the invention have the formula (1) as described above. More particularly, compounds of formula (I) can include, but are not limited to, compounds wherein A is N, and n is 1 or 2. Certain preferred compounds exist wherein A is N; L is O; n is 2.
More particularly, in compounds of formula (I) Ar is selected from:


wherein R|, R2, R3, R4 and R5 are independently acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylsulfonyl, alkynyl, amino, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy, -NRgR,, (NRgRj)alkyl, (NRgRj)alkoxy, (NRgRj)carbonyl, or (NRgRj)sulfonyl; Rg and Rj are each independently hydrogen or alkyl. More preferably, Ar' is

Particularly, the invention includes, but is not limited to, compounds of formula (I) wherein A is N; R is methyl; L is O; n is 2; Ar is

Ar*^ in compounds of formula (I) is selected from:


wherein Z1, Z2, Z3 and Z4 are each independently nitrogen or are carbon, wherein the carbon atom is optionally substituted with a substituent selected from the group consisting of hydrogen, halogen, alkyl, -ORc. -alkyl-ORc -NRdRe, and -alkyl-NRdRe; Ri, is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; Re is alkyl; Rd and Re ai'e each independently selected from the group consisting of hydrogen and alkyl, R6 and R7 are each independently selected from the gioup consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycaibonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfonyl. alkynyl, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydrogen, hydroxy, hydroxyalkyl, mercapto, nilro, thioalkoxy, -NRgRj, (NRgRj)alkyl, (NRgRi)alkoxy, (NRgRj)carbonyl, and (NRgRi)sulfonyl; Rg and Rj are each independently selected from the gioup consisting of hydrogen and alkyl.
R is selected from hydrogen, alkyl, cycloalkylalkyl, and arylalky. Prefened compounds are disclosed wherein R is hydrogen and alkyl. Preferably, R is methyl and hydrogen.
Preferred compounds are disclosed wherein Ar" is

More preferably Ar2 is


Particularly, the invention relates to compounds of formula (I) wherein A is N; R is selected from methyl and hydrogen; L is O; n is 2; and Ar" is selected from the group of consisting of:
More particularly, the invention relates to compounds of formula (I) wherein A is N; R is methyl or hydrogen; L is O; n is 2; Ar' is
Ar2 is
R7
(i).
Compounds for the method of the invention, including but not limited to those specified in the examples or otherwise specifically named, can modulate, and often possess an affinity for, nAChRs, and more particularly a7 nAChRs. As a7 nAChRs ligands, the compounds of the invention can be useful for the treatment or prevention of a number of a7 nAChR-mediated diseases or conditions.
Specific examples of compounds that can be useful for the treatment or prevention of a7 nAChR-mediated diseases or conditions include, but are not limited to, compounds described in the Compounds of the invention and also in the Examples, and

also compounds such as;
5-{6-(endo)-8-methyl-8-aza-bicyclo[3.2.1|ocl-3-yloxy|-pyndazin-3-yl)-lH-indole;
(endo-(6-benzo[b|lhiophcn-5-yl-pyridazin-3-yIoxy)-8-mclhyl-8-aza-bicyclol 3.2.1 Joctane;
(endo-[6-(benzofuran-5-yl)-pyridazin-3-yloxyl-8-mclhyl-8-aza-bicyclo(3.2.11octane;
6-{6-|(endo-melhyl-8-aza-bicyclo|3.2.1|ocl-3-yloxy]-pyridazin-3-yl!-lH-indolc;
5-{6-[(endomethyl-8-aza-bicyclo[3.2.1]oct-3-yloxy|-pyridazin-3-yl)-lH-indazole;
l-methy]-5-{6-|{endo-methyl-8-aza-bicyclo| 3.2.1 |oct-3-yloxy |-pyridazin-3-ylj-lH-indole;
5-(6-l((endo)ethyl-8-aza-bicyclo|3.2.1 joct-3-yloxy|-pyridazin-3-yl}-2-trifluoromethyl-1 H-indole;
5-{6-[(exo-methyl-8-aza-bicyclo|3.2.1]oct-3-yloxyl-pyridazin-3-yl}-lH-indole;
5-{5-[(endo)thyl-8-aza-bicyclo|3.2.1 |oct-3-yloxy]-pyridin-2-yl}-l H-indole;
(endo)6-benzo|b|thiophen-5-yl-pyridin-3-yloxy)-8-methyl-8-aza-bicyclo|3.2.1|octane;
5- {5-|(exo-mclhyl-8-aza-bicyclo( 3.2.1 |oct-3-yloxy | -pyridin-2-yl} -1 H-indole;
(exo)-3-[6-(benzofuran-5-yl)-pyridin-3-yloxy]-8-methyl-8-aza-bicyclo[3.2.11octane;
5-{5-|(exo)ethyl-8-aza-bicyclo|3.2.r|oct-3-yloxyl-pyridin-2-yl)-lH-indazole;
5-{5-|(exo8-methyl-8-aza-bicyclo[3.2.1|ocl-3-yloxy|-pyridin-2-yl)-2-trinuoromcthy 1-1 H-indole;
4-{5-[((exo-methyl-8-aza-bicyclo| 3.2. lloct-3-yloxyl-pyridin-2-yl}-l H-indole;
5-{6-[(endomethyl-8-aza-bicyclo|3.2.rioct-3-yloxyl-pyridin-3-yl}-lH-indolc;
(e/7t/o)-3-(5-benzo[blthiophen-5-yl-pyridin-2-yloxy)-8-methyl-8-aza-bicyclol 3.2.1 joctane;
5-{6-[((exo-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxy|-pyridin-3-yl}-l H-indole;
|6-(lH-indol-5-yl)-pyridin-3-yll-|(end8-melhyl-8-aza-bicyclo[3.2.11oct-3-yl]-aniine;

[6-(benzofuran-5-yl)-pyridin-3-ylj-[(end8-methyl-8-aza-bicyclol3.2.]]oct-3-yl I-amine;
|(endo-8-methyl-8-aza-bicyclo| 3.2.1 |oct-3-yl|-|6-(2-trif]uoromethyl-lH-indol-5-yl)-pyridin-3-ylJ-amine;
r6-(lH-indazol-5-yl)-pyridin-3-yl]-|(endo-mclhyl-8-aza-bicyclo[3.2.11oct-3-yl I-amine;
|6-(]H-indol-4-yl)-pyridin-3-yl]-|{endo)-melhyl-8-aza-bicyclo|3.2.]loct-3-yl]-amine;
|(end-8-aza-bicyclo[3.2.1|ocl-3-yll-|6-(lH-indol-5-yi)-pyridin-3-yll-aminc ;
|4-(lH-indol-5-yl)-phenyll-|((endomethyl-8-aza-bicyclo|3.2.1|oct-3-yl]-amine;
|4-(lH-indazol-5-yl)-phenyl|-|(endomcthyl-8-aza-bicyclo|3.2.1Joct-3-yll-amine;
[(endo-methyl-8-aza-bicyclo[3.2.i|ocl-3-yil-|4-(l-methyl-lH-indol-5-yl)-phenyl]-amine;
(4-benzo|b]thiophen-5-yl-phenyl)-[(endoethyl-8-aza-bicyclo|3.2.1 |oct-3-yl I-amine;
[4-(benzofuran-5-yl)-phenylJ-[(endomethyl-8-aza-bicyclo[3.2.11oct-3-yll-amine;
|4-(lH-indol-4-yl)-phenyl|-[(d'?7(;/o)-8-methyl-8-aza-bicyclo|3.2.r|oct-3-yl|-amine;
[3-(lH-indoi-5-yI)-phenyll-[((endomethyi-8-aza-bicyclo|3.2.11ocl-3-yi]-aminc;
[3-{lH-indol-4-yl)-phenyll-|(endo)methyl-8-aza-bicyclo|3.2.1|oct-3-yl|-amine;
5-{6-[(endomethyl-8-aza-bicyclo|3.2.1]oct-3-yioxy]-pyridazin-3-yl}-2-trifluoromethyl-lH-indole;
4-{6-|(exo)melhyl-8-aza-bicyclo[3.2.i|ocl-3-yloxy|-pyridazin-3-yl)-lH-indole;
5-{6-|(exo8-methyl-8-aza-bicyclo|3.2.11oct-3-yloxyl-pyridin-3-yl}-lH-indole;
5-{ 6-1 (exo)-8-methyl-8-aza-bicycio| 3.2.1 ]oct-3-yloxy]-pyridin-3-yi}-2-
triniioromelhyl-1 H-indole;
4-{6-|(exo8-methyl-8-aza-bicyclo|3.2.1|ocl-3-yloxy|-pyridazin-3-yl}-lH-indolc; 6-{5-[(exo8-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxy|-pyridin-2-yl}-l H-indole; 5-{5-|(end8-methyl-8-aza-bicyclo[3.2.11oct-3-yloxy]-pyrazin-2-yl 1-1 H-indole; 4-{5-[(endomethyl-8-aza-bicyclo|3.2.11oct-3-yloxyl-pyrazin-2-yl]-l H-indole;

6-{5-l(endo)-8-methyl-8-aza-bicyclol3.2.11oct-3-yloxyl-pyrazin-2-yri-lH-indole; |6-(lH-indol-6-yl)-pyridin-3-yl|-[(endo;)-8-inclhyl-8-aza-bicyclo|3.2.1|oct-3-yl]-amine;
5-{6-((end9-mcthyl-9-azabicyclo(3.3.1|nonan-3-yloxylpyiidazin-3-yl}-lH-indolc;
(endo-[6-(benzo[b|thiophen-5-yl)pyridazin-3-yloxy|-9-mclhyl-9-azabicyclo[3.3.1]nonanc;
5-{5-[(endo)-methyl-8-aza-bicyclo|3.2.1]oct-3-yloxy|-pyrazin-2-yl}-lH-pyiTolo|2,3-b]pyridine;
5-{5-|(endomethyl-8-aza-bicyclo| 3.2.1 |oct-3-yloxy|-pyridin-2-yl}-lH-pyrrolo[2,3-blpyridine;
5-{5-|(endo)ethyl-8-aza-bicyclo[3.2.1Joct-3-yloxy|-pyrldin-3-yl}-lH-indole;
5-{5-|(exo-methyl-8-aza-bicyclo|3.2.11ocl-3-yloxyl-pyiazin-2-yl)-lH-indole;
4-{5-[(exo-methyl-8-aza-bicyclo|3.2.1 |oct-3-yloxy|-pyrazin-2-yl)-lH-indole;
6-{5-[(endo-methyl-8-aza-bicyclo|3.2.1 |oct-3-yloxy|-pyrazin-2-yl)-lH-indole;
(endo)5-(lH-Indol-5-yl)pyridin-3-yl)-8-methyl-8-azabicyclo|3.2.1|octan-3-amine;
{endo)-N-i5-{ lH-Indol-4-yl)pyridin-3-yl)-8-methyl-8-azabicyclo|3.2.1 loctan-3-amine;
(endo-N-H-Indol-6-yl)pyridin-3-yl)-8-methyl-8-azabicyclo[3.2.1 |oclan-3-aniine;
.6'/7Jo)-A^-{5-|2-(lrinuoromethyl)-lH-indol-5-yl]pyridin-3-yl)-8-Melhyl-8-azabicyclol 3.2.1 ]octan-3-amine;
5-{5-|((?«Jo)-8-Methyl-8-azabicyclo[3.2.11oclan-3-yloxylpyridin-2-yl}-lH-pyiTolo(2,3-b]pyridinc;
5- {5-|(f «t/o)-8-Mcthyl-8-azabicyclo| 3.2.1 |oclan-3-yloxy |pyridin-2-yl} indolin-2-onc;
5-{5-(endoAzabicyclo[3.2.11oclan-3-yloxy|pyridin-2-yl}-lH-indolc;
(7/?,-?r,55,&)-3-(6-(lH-Indol-5-yl)pyridin-3-yloxy)-8-methyl-8-azabicyclo[3.2.1 |octane 8-oxide;
(7/?,ir,55,Sr)-3-(6-(lH-Indol-5-yl)pyiidin-3-yloxy)-8-mcthyl-8-azabicycIo|3.2.1 ]octane 8-oxide;

4-{5-(endo)-8-Azabicyclol3.2.l|octan-3-yloxylpyridin-2-yl}-lH-indole; 5-{5-[(endo;)-8-Azabicyclo|3.2.11octan-3-yloxy|pyndin-2-ylj-lH-indole; 5-{5-[(endo)-8-Azabicyclo|3.2.1|octan-3-yloxy|pyridin-2-yl}indolin-2-one; 5-{ 5-(endo)-8-Azabicyclo[3.2.1 loctan-3-yloxy |pyridin-2-yI}-1 H-pyn-olo[2,3-b] pyridine;
5-{5-|((?Ao)-8-Azabicyclo|3.2.1|octan-3-yloxy]pyridin-2-yl}-lH-pyrrolo|2,3-b] pyridine,
or pharmaccutically acceptable salts, esters, amides, and prodrugs thereof.
Compound names are assigned by using AuToNoM naming software, which is provided by MDL Information Systems GmbH (formerly known as Beilstein Informationssysteme) of Frankfurt, Germany, and is part of the CHEMDRAW® ULTRA V. 6.0.2 software suite.
Compounds of the invention may exist as stereoisomers wherein, asymmetric or chiral centers are present. These stereoisomers are "R" or "S" depending on the configuration of substituents around the chiral element. The terms "R" and "S" used herein are configurations as defined in lUPAC 1974 Recommendations for Section E. Fundamental Stereochemistry, Pure Appl. Chem., 1976, 45: 13-30.

The attachment of L to the azabicyclic alkane may be considered to encompass both the endo and cxo geometries, such as isomer (la) and (lb). The configurational assignment of structures of formula (la) are assigned endo in accordance with that described in Stereochemistry of Organic Compounds, E.L. Eliel, S.H Wilen; John Wiley and Sons, Inc. 1994. Structures of formula (lb) are assigned exo using the same methods.

The N^^-O" portion of isomer (Ic) and isomer (Id) aie diastereomers. The configurational assignment of structures of formula (Ic) are assigned (r) in accordance

with that described in Synthesis, 1992, 1080, Becker, D. P.; Flynn, D.L. and as defined in Stereochemistry of Organic Compounds, E.L. Elicl, S.H Wilen; John Wiley and Sons, Inc. 1994. In addition the configurational assignment of structures of formula (id) are assigned (s) using the same methods.
The invention contemplates various stereoisomers and mixtures thereof and are specifically included within the scope of this invention. Stereoisomers include cnantiomcrs and diastereomers, and mixtures of enantiomcrs or diastereomers. Individual stereoisomers of compounds of the invention may be prepared synthetically from commercially available starting materials which contain asymmetric or chiral centers or by preparation of racemic mixtures followed by resolution well-known to those of ordinary skill in the art. These methods of resolution arc exemplified by (1) attachment of a mixture of enantiomers to a chiral auxiliary, separation of the resulting mixture of diastereomers by rccrystallization or chromatography and optional liberation of the optically pure product from the auxiliary as described in Furniss, Hannaford, Smith, and Tatchell, "Vogel's Textbook of Practical Organic Chemistry", 5th edition (1989), Longman Scientific & Technical, Essex CM20 2JE, England, or (2) direct separation of the mixture of optical enantiomers on chiral chromatographic columns or (3) fractional recrystallization methods.

Methods for Preparing Compounds of the Invention
The reactions exemplified in the schemes are performed in a solvent appropriate to the reagents and materials employed and suitable for the transformations being effected. The described transformations may require modifying the order of the synthetic steps or selecting one particular process scheme over another in order to obtain a desired compound of the invention, depending on the functionality present on the molecule.
The methods described below can entail use of various enantiomers. Where the stereochemistry is shown in the Schemes, it is intended for illustrative purposes only.

Compounds of formula (8), wherein Ar', Ar" are as defined in formula (I), can be prepared as described in Scheme 1. Compounds of formula (1) when treated with a compound of formula (2a), wherein halo is bromide, chloride, or iodide, in the presence of Cul, l,l()-phenanthroline and CS2CO3 in a solvent such as, but not limited to, toluene as described in Org. Lett., 2002, 4, 973, will provide compounds of formula (3). Compounds of formula (3) can also be prepared through the rection of compounds of formula (1) with compounds of formula (2b) in the presence of a base, such as, but not limited to, KHMDS, in a solvent such as but not limited to THF, DME and toluene. Compounds of formula (3) when treated with hexamethylditin or an organo-boranc

compound of formula (4), such as bis(pinacolato)diboron or bis(catecholato)diboron, wherein R is hydrogen, alky! or aryl, in the presence of a palladium catalyst will provide the corresponding tin or boronic acid of formula (5), wherein M is -Sn-(Me)3 or -B(OR)2. Compounds of formula (5) when treated with compounds of formula (6), Ar'-halo, wherein Ar" is a bicyclic heteroaryl ring and halo is bromide, chloride, or iodide, in the presence of a palladium catalyst to provide compounds of formula (8). Alternatively, compounds of formula (6) when treated with hexamethylditin or a di-borane containing compound of formula (4), such as bis(pinacolato)diboron and bis(catecholalo)diboron, in the presence of a palladium catalyst will provide a concsponding tin or boronic acid containing compound of formula (7), wherein Ar' is a bicyclic heteroaryl and wherein M is -Sn-{Mc)3 or -B(0R)2. Compounds of formula (7) when treated with a compound of formula (3) in the presence of a palladium catalyst will provide a compound of formula (8).

Compounds of formula (13), wherein Ar' is a nitrogen-containing heteroaryl, for examples pyridazine, pyrimidine, pyrazine, 2-pyridyl, and Ar" is as defined for formula (I), can be prepared as shown in Scheme 2. Compounds of formula (9), wherein R^ is alkoxyalkyl, alkyl, alkyloxycarbonyl, alkylcarbonyl, aryl, arylalkyloxycarbonyl, cycloalkylalkyl, arylcarbonyl and aryloxycarbonyl and K represents the potassium, which are prepared from treating hydroxyl containing heterocycles of similar formula with potassium tert-butoxide in solvents such as but not limited to THF or DMF to provide the

potassium oxide containing compounds of formula (9). The compounds of formula (9) when treated with compounds of formula (10), wherein Y' and halo arc both bromo, chloro and iodo, and X2 X3,X4 and X5 are independently either carbon or nitrogen, for example, dichloropyridazine, will provide compounds of formula (11). Compounds of formula (11) when treated with hexamethyldilin or a di-boranc containing compound of formula (4) in the presence of a palladium catalyst according to the procedure outlined in Scheme 1 will provide compounds of formula (12). Compounds of formula (12) treated with compounds of formula 6 in the presence of a palladium catalyst will provide compounds of fomula (13). Alternatively, the compounds of formula (11) when treated with organo stannane or organo boronic acid containing compounds of formula (7), as described in Scheme 1, in the presence of a palladium catalyst will provide a compound of formula (13).

Alternatively, compounds of formula (8) may be prepared as outlined in Scheme 3. Compounds of formula (1) when treated with a compound of formula (14), wherein Z is bromo, chloro or iodo or is Ar'^, in the presence of diethyl azodicarboxylatc or di(isopropyl)l azodicarboxylatc and a phosphine, such as iriphenylphosphine, will provide compounds of formula (15). When T} is Ar', compounds of formula (15) arc representative of the present invention. When l} is a halogen, the further treatment of the compound according to conditions outlined in Schemes 1-2 outlining the Su/uki type coupling to provide compounds of formula (8) which are representative of the

compounds of the present invention.

Another method of generating compounds of formula (8) is described in Scheme 4. The activated tin or boronic acid compounds of formula (7) can be coupled with a variety of aryl halides that will provide a method of generating biaryl compounds of formula (17) and of formula (20). For example compounds of formula (7) when treated with diiodobenzene of formula (16) in the presence of a palladium catalyst will provide compounds of formula (17). Compounds of formula (17) when treated with compounds of formula (1) in the presence of cuprous iodide and cesium carbonate and 1, 10-phenanthroline as described in scheme 1, will provide compounds of formula (8). Alternatively, compounds of formula (7) when treated with a compound of formula (18), wherein R" is benzyl or another appropriate alcohol protecting gioup, in the presence of a palladium catalyst will provide compounds of formula (19). The dcprotection of the alcohol protecting group, for example when R" is benzyl the dcprotection is generally achieved utilizing palladium on carbon and an atmosphere of hydrogen, will provide compounds of formula (20). Compounds of formula (20) when treated with compounds of formula (1) in the presence of triphenylphosphine and diethyldiazocarboxylate or a

similar reagent will provide compounds of formula (8).

Compounds of formula (25), which are representative of compounds of formula (I), wherein L is -NH-, can be prepared as shown in Scheme 5. Compounds of formula (21) when treated with compounds of formula (22), wherein halo is bromide, chloride, or iodide, along with sodium triacetoxy borohydride and Na2S04 in acetic acid will provide compounds of formula (23). Alternatively, a compound of formula (23) can be obtained by treating compounds of formula (24) with a compound of formula (2), wherein Y is bromo or iodo, in the presence of palladium catalyst, preferably in toluene. Compounds of formula (23) when further treated with a tin or diboron of formula (4), such as bis(pinacolato)diboron and bis(calecholato)diboron, under conditions described in Scheme 2, will provide the corresponding tin or boronic acid compounds of formula (26). Compounds of formula (26) when treated with a compound of formula (6) in the presence of a palladium catalyst, will provide the compound of formula (25). Alternatively, the compound of formula (23) when treated with a tin or boronic acid containing compound of formula (7) in the presence of a palladium catalyst will also provide compounds of formula (25).


In addition, compounds of formula (25) can be prepared as sliown in Scheme 6. Ketone containing compounds of formula (21), when treated with compounds of formula (27). prepared via the coupling reaction of haloarylamine of formula (22) and a suitable tin or boron agent of formula (7) in the presence of a palladium catalyst, followed by treatment with sodium triacetate borohydride and Na2S04 in acetic acid will provide compounds of formula (25) as described in Tetrahedron Lett. 1996, 37, 6045.

Compounds of formula (31), wherein L is S and Ar and Ar"^ are as defined in formula (I), can be prepared as shown in Scheme 7. Compounds of formula (29). wherein halo is bromide, chloride, or iodide, when pretreated with sodium hydride in a solvent such as but not limited to DMF followed by treatment with compounds of formula (28) will provide compounds of formula (30). Compounds of formula (30) when treated with a compound of formula (7) as described in Scheme 1, will provide compounds of formula (31), which are representative of compounds of formula (I)

wherein L is S. Alternatively, the compound of formula (30) when treated with a hcxamethylditin or diboron reagent of formula (4), such as bis(pinacolato)diboron and bis(catecholato)diboron, in the presence of a palladium catalyst will provide a compound of formula (32). Compounds of formula (32) when treated with compounds of formula (6), wherein halo is bromo, chloro or iodo, in the presence of a palladium catalyst will provide compounds of formula (31).

Compounds of formula (35) which arc representative of compounds of formula (I), wherein L is O, S, or -N(Ra)-, Ar' is as prcviouly defined in formula (I), and Ar2 is an aminosubstituted benzothiazole are prepared according to the conditions outlined in Scheme 8. Compounds of formula (33) which are obtained by methods described in Schemes 1-7, wherein Ar1 is substituted with -NH2, when treated with bromine and KSCN in acetic acid will provide compounds of formula (34). Compounds of formula (34) can be further treated with the halidc of a desired R'^ group, wherein R^ is as defined under the scope compounds of the present invention to provide compounds of formula (35).


Compounds of formula (39), wherein L is O, NH, or S; Ar' is as previouly defined in formula (I), Ar2 is a benzoimidazole as defined for compounds of formula (I), are prepared as outlined in Scheme 9. Compounds of formula (36), are obtained by treating compounds of formula (33) of Scheme 8, using conditions known to one skilled in the art that will incorporate a nitrogen-protecting group to the nitrogen atom of Ar" wherein P is tert-butyloxycarbonyl, benzyloxycarbonyl, alkoxycarbonyl, alkylcarbonyl, arylcarbonyl or trialkylsilane. Compounds of formula (36) when treated with nitric acid in sulfuric acid will provide compounds of formula (37). Compounds of formula (37) when subjected to reducing conditions such as but not limited to treatment with a palladium catalyst and an atmosphere of hydrogen will reduce the nitro group to the corresponding amine, which is subjected to conditions known to one skilled in the art that will remove the nitrogen protecting group to provide compounds of formula (38). Compounds of formula (38) were then further subjected to treatment with an excess of an orthoester of formula (EtO)3CR'" will provide compounds of formula (39) wherein R'" is alkyl or aryl.
Scheme 10


Benzooxazole-containing compounds of formula (44), wherein L is O, NH, or S, Ar is as previouiy defined in formula (I), and R" is alkyl hydrogen, or aryl, can be prepared as outlined in Scheme 10. Compounds of formula (40) can be treated with a dilin or diboron reagent of formula (4). such as hexamethyldilin, bis(pinacolato)diboron and bis(catecholato)diboron. in the presence of a palladium catalyst to provide the corresponding tin or boronic acid of formula (41). Compounds of formula (41) when treated with a halogen containing compound of formula (42) in the presence of a palladium catalyst will provide compounds of formula (43). Compounds of formula (43) when treated according to conditions known to one skilled in the art that will reduce nitro groups to the corresponding amine group, followed by treatment with a R" substituted ortho ester, wherein R" is hydrogen, alkyl or aryl will provide compounds of formula (44).
In addition, compounds of formula (I) wherein A is N can be converted to compounds of formula (I) wherein A is N"^-0" by treatment with an oxidizing agent. Examples of the oxidizing agent include, but not limited to, aqueous hydrogen peroxide and m-chloroperbcnzoic acid. The reaction is generally performed in a solvent such as, but not limited to, acetonitrile, water, dichloromethane, acetone or mixture thereof, preferably a mixture of acetonitrile and water, at a temperature from about 0° C to about 80° C, for a period of about 1 hour to about 4 days.
The compounds and intermediates of the invention may be isolated and purified by methods well known to those skilled in the art of organic synthesis. Examples of conventional methods for isolating and purifying compounds can include, but are not limited to, chromatography on solid supports such as silica gel, alumina, or silica derivatized with alkylsilane groups, by recrystallization at high or low temperature with

an optional pretreatment with activated carbon, thin-layer chromatography, distillation at various pressures, sublimation under vacuum, and trituration, as described for instance in "Vogel's Textbook of Practical Organic Chemistry", 5th edition (1989), by Furniss, Hannaford, Smith, and Tatchell, pub. Longman Scientific & Technical, Essex CM2() 2JE, England.
The compounds of the invention have at least one basic nitrogen whereby the compound can be treated with an acid to form a desired salt. For example, a compound may be reacted with an acid at or above room temperature to provide the desired salt, which is deposited, and collected by filtration after cooling. Examples of acids suitable for the reaction include, but are not limited to tartaric acid, lactic acid, succinic acid, as well as mandelic, atrolactic, methanesulfonic. ethanesulfonic, toluenesulfonic, naphthalenesulfonic, carbonic, fumaric, gluconic, acetic, propionic, salicylic, hydrochloric, hydrobromic, phosphoric, sulfuric, citric, or hydroxybutyric acid, camphorsulfonic, malic, phenylacetic, aspartic, glutamic, and the like.
Nitrogen protecting groups can be used for protecting amine groups present in the described compounds. Such methods, and some suitable nitrogen protecting groups, are described in Greene and Wuts (Protective Groups In Organic Synthesis, Wiley and Sons, 1999). For example, suitable nitrogen protecting groups include, but are not limited to, tert-butoxycarbonyl (Boc), benzyloxycarbonyl (Cbz), benzyl (Bn), acetyl, and trifluoracetyl. More particularly, the Boc protecting gi-oup may be removed by treatment with an acid such as trifluoroacetic acid or hydrochloric acid. The Cbz and Bn protecting groups may be removed by catalytic hydrogenation. The acetyl and trifluoracetyl protecting groups may be removed by a hydroxide ion.
The compounds and processes of the invention will be better understood by reference to the following Examples, which are intended as an illustration of and not a limitation upon the scope of the invention.
Example 1 5-16-[(endo)-8-Methvl-8-aza-bicvclol3.2.1 loct-3-vloxvl-Pvridazin-3-vn- IH-indole
tritluoroacetate

Example lA (endo)-3-(6-chloro-pvridazin-3-vloxv)-8-methyl-8-aza-bicyclo|3.2.r| octane A mixture of (endo)-tropine (Aldrich, 706 mg, 5.0 mmol), 3,6-dichloropyridazine [Aldrich, 745 mg, 5.0 mmol) and potassium t-butoxide (Aldrich, 1.12 g, 10 mmol) in THE (anhydrous, Aldrich, 25 mL) was stiired at 60 "C under an atmosphere of nitrogen for 16 hours. The mixture was concentrated under reduced pressure and the residue purified by chromatography (150 g Si02, EtOAc: MeOH : NH3H2O, 90:10:1, R,. 0.20) to provide the title compound. 'H NMR (300 MHz, CD3OD) 5 2.03 - 2.36 (m, 8 H), 2.45 (s. 3 H), 3.38 [s (br.), 2 H), 5.40 (t, J=5.09 Hz, 1 H), 7.20 (d, .1=9.16 Hz, 1 H), 7.66 (d, J=9.16 Hz, 1 H) ppm; MS (DCI/NH3) nVz 254 (M+H)^.
Example IB 5-{6-|(endo)-8-Methvl-8-aza-bicvclo|3.2.1 |oct-3-vloxy|-pYridazin-3-vU-lH-indole
trifluoroacetatc The mixture of Example 1A (112 mg, 0.44 mmol), 5-(4,4,5,5-tetramethyl-[l,3,2|dioxaborolan-2-yl)-lH-indole (Aldrich, 232 mg, 0.954 mmol), bis(triphenylphosphine)palladium(II) chloride (Aldrich, 7.02 mg, 0.01 mmol) and biphenyl-2-yl-dicyclohexyl-phosphane (Strem Chemicals, 10.5 mg, 0.03 mmol) in dioxane/EtOH/Na2C03 (aq., 1 M) (v. 1/1/1, 3 mL) were heated and microwaved to 150 °C and 300 watts for 15 minutes in an Emry™ Creator microwave. The solid was filtered off with a syringe filter and the organic solution was directly purified by preparative HPLC (Gilson, column, Xterra® 5μm, 40 x 100 mm. Eluting Solvent, MeCN / H2O containing 0.1% v. TEA (90% to 10%. over 25 minutes. Flow rate of 40 niL/minute, uv detector set to 254 nm). The fractions containing the desired product were collected and concentrated under reduced pressure and the residue was stirred in ether/ethanol (v. 10/1, 5 mL) at ambient temperature for 16 hours to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.31 - 2.60 (m, 8 H), 2.85 (s, 3 H), 3.97 [s (br.), 2 H], 5.53 - 5.62 (m, 1 H), 6.56 (d, J=3.05 Hz, 1 H), 7.24 - 7.34 (m, 2 H), 7.51 (d, J=8.48 Hz, 1 H), 7.74 (dd, J=8.65, 1.86 Hz, 1 H), 8.09 - 8.17 (m, 2 H) ppm; MS (DCI/NH3) iTi/z 335 (M+H)^ Anal. Calculated for C2()H22N40-1.05 CF3CO2H-0.50 C2H5OH: C, 58.14; H, 5.50; N, 11.74. Found: C, 58.07; H, 5.44; N, 11.75.

Example 2 (endo)-3-(6-Benzo|b|thiophen-5-yl-pyridazin-3-vloxv)-8-methvl-8-aza-bicvclol3.2.1 loctanc tiifluoroacetatc The product from Example lA (121 mg, 0.48 mmol) and 2-benzo[b]lhiophen-5-yl-4,4,5,5-tetramethyl-[l,3,2|dioxaborolane (Maybridgc, 219 mg, 0.84 mmol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.33 - 2.58 (m, 8 H), 2.86 (s. 3 H), 3.94 - 4.02 (m, 2 H), 5.57 - 5.64 (m, 1 H), 7.34 (d, J=9.15 Hz, 1 H), 7.50 (d. J=5.42 Hz, 1 H), 7.67 (d, J=5.42 Hz, 1 H), 7.98 (dd, J=8.48, 1.70 Hz, 1 H), 8.06 (d. J=8.48 Hz, 1 H), 8.20 (d, J=9.15 Hz, 1 H), 8.44 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH3): m/z 352 (M+H)^ Anal. Calculated for C2()H2iN3OS-1.10CF3CO2H: C, 55.91; H, 4.67; N, 8.81. Found: C, 55.90; H, 4.41; N, 8.59.
Example 3 (endo)-3-|6-(Benzofuran-5-yl)-pyridazin-3-vloxvl-8-methvl-8-a7.a-bicvclo[3.2.1|octane
trifluoroacetate The product from Example lA (131 mg, 0.52 mmol) and 1-benzofuran-5-ylboronic acid (Apollo, 166 mg, 1.02 mol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.33 - 2.64 (m, 8 H), 2.86 (s, 3 H), 3.94 - 4.02 (m, 2 H), 5.56 - 5.63 (m, 1 H), 6.96 (d, J=1.36 Hz. 1 H), 7.32 (d, J=9.16 Hz, 1 H), 7.65 (d, J=8.82 Hz, 1 H), 7.84 (d. J=2.37 Hz, 1 H), 7.93 (dd, J=8.82, 2.03 Hz, 1 H), 8.15 (d, J=9.49 Hz, 1 H), 8.22 (d, J=1.36 Hz. 1 H) ppm; MS (DCI/NH3): m/z 336 (M+Uf. Anal. Calculated for C2()H2iN302l.l CF3CO2H: C, 57.86; H, 4.83; N, 9.12. Found: C, 58.10; H, 4.54; N. 9.06.

Example 4 6-{6-[(endo)-8-Methvl-8-aza-bicvclor3.2.11oct-3-vloxy|-pvridazin-3-vll-lH-indole
trifluoroacetatc The product of Example lA (158 mg, 0.62 mmol) was coupled with indole-6-boronic acid (Frontier, 162 mg, 1.01 mol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.33 - 2.59 (m, 8 H), 2.85 (s, 3 H), 3.93 - 4.01 (m, 2 H), 5.58 (t, J=3.()5 Hz, 1 H), 6.51 (d. J=3.05 Hz, 1 H), 7.29 (d, J=9.16 H/, 1 H), 7.35 (d, J=3.05 Hz. 1 H), 7.58 - 7.64 (m, 1 H), 7.66 - 7.73 (m, 1 H), 8.01 (s, 1 H), 8.13 (d. J=9.49 Hz, 1 H) ppm. MS (DCI/NH3): m/z 335 (M+H^. Anal. Calculated for C2„H2iN4O1.10 CFCO.H: C, 57.99; H, 5.06: N, 12.18. Found: C, 58.09; H, 4.95; N, 11.97.
Example 5 5-{ 6-1 (endo)-8-Methyl-8-aza-bicyclo| 3.2.1 |oct-3-yloxy|-pyridazin-3-vll-lH-indazole
fumarate
Example 5A 5-(4.4.5.5-tetramethyl-l,3.2-dioxaborolan-2-vl)-lH-indazole A flask containing 5-bromo-lH-indazolc (Rcf. US 2003199511, 9.45 g, 48 mmol) and bis(pinacolato)diboron(Aldrich, 15.5 g, 61 mmol) in dry DMF (160 mL) was added KOAc (16.7 g, 170 mmol). The mixture was degassed and purged with N2 three times followed by the addition of PdCl2(dppf)CH2Cl2 (Aldrich, 985 mg, 1.21 mmol). The mixture was heated to 90°C and stincd for 24 hours. The mixture was cooled to ambient temperature, diluted with ethyl acetate (250 mL), washed with water (2 x 50 mL). The organic phase was concentrated under reduced pressure and the residue was purified by chromatography (400 g Si02, hexane : EtOAc 90 : 10, Rt=0.6) to provide the title compound. 'H NMR (300 MHz, CD3OD) 5 1.36 (s, 12 H), 7.51 (dt, J=8.48, 1.02 Hz, 1 H), 7.73 (dd, J=8.48, 1.02 Hz, 1 H), 8.08 (d, J=1.02 Hz, 1 H), 8.23 (t, J=l.()2 Hz, 1 H) ppm. MS (DCI/NH3): nVz 245 (M+H)^.
Example 5B

5-{6-|(endo)-8-Methvl-8-aza-bicvclo|3.2.1|oct-3-yloxvl-pvridazin-3-vU-lH-indazole A mixture of Example lA (158 mg, 0.62 mmol) and the product of Example 5A (308 mg, 1.26 mol) were treated with bis(triphenylpho.sphine)palladium(n) chloride (Aldrich, 7.02 mg, 0.01 mmol) and biphcnyl-2-yl-dicyclohcxyl-phosphane (Strem Chemicals, 10.5 mg, 0.03 mmol) in dioxanc/EtOH/Na2C03 (aq., 1 M) (v. 1/1/1, 3 mL) were heated and microwaved to 150 °C and 300 watts for 15 minutes in an Emry^'^ Creator microwave reactor. The mixture was cooled to ambient temperature, solid was filtered off with a syringe filter and the organic solution was directly purified by chromatography (40 g Si02, EtOAc:MeOH:NH.vH20, 90:10:1, R,=0.10) to provide the title compound. 'H NMR (300 MHz, CDiOD) 5 2.02 - 2.33 (m, 8 H), 2.36 (s, 3 H), 3.25 Is (br.), 2 H], 5.47 (t, J=4.92 Hz, 1 H), 7.23 (d, J=9.16 Hz, 1 H), 7.67 (dt, J=8.82, 0.85 Hz, 1 H), 8.07 (dd, J=8.82, 1.70 Hz, 1 H), 8.10 - 8.19 (m, 2 H), 8.36 (dd, J=1.53, 0.85 Hz,
1 H) ppm; MS(DCI/NH3): m/z 336 (M+H)^
Example 5C 5-i6-|(endo)-8-Methyl-8-aza-bicyclo|3.2.1|oct-3-vloxvl-pvridazin-3-yll-lH-indazole
fumarate The product of Example 5B (128 mg, 0.38 mmol) was treated with fumaric acid (46 mg, 0.40 mmol) in EtOAc/EtOH (v. 1:1,5 mL) at ambient temperature for 15 hours. The mixture was filtered to provide the titled compound. 'H NMR (300 MHz, CD3OD) 8 2.29 - 2.61 (m, 8 H), 2.86 (s, 3 H), 3.90 - 3.99 (m, 2 H), 5.59 (t, J=4.92 Hz, 1 H), 6.69 (s,
2 H), 7.32 (d, J=9.16 Hz, 1 H), 7.68 (d, J=8.82 Hz, 1 H), 8.08 (dd, J=8.82, 1.70 Hz, 1 H),
8.15 - 8.21 (m, 2 H), 8.38 (dd, J=1.70, 0.68 Hz. 1 H)ppm; MS(DCI/NHO: m/z 336
(M+Hf. Anal. Calcd. for C|„H2iN50-1.20 C4H4O4: C, 60.22; H, 5.48; N, 14.75. Found:
C, 60.03; H, 5.17; N, 14.85.
Example 6 l-Methyl-5-{6-l(endo)-8-methyl-8-aza-bicyclo|3.2.lloct-3-yloxy1-pyridazin-3-yll-lH-
indole trifluoroacetatc The product of Example 1A (121 mg, 0.48 mmol) and N-methylindole-5-boronic acid (Frontier, 175 mg, 1.0 mol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.22 - 2.70

(m, 8 H), 2.86 (s, 3 H), 3.93 - 4.03 (m, 2 H), 5.53 - 5.62 (m, 1 H), 6.57 (d, J=3.05 Hz, 1 H), 7.26 (d, J=3.39 Hz, 1 H), 7.37 (d, J=9.49 Hz, 1 H), 7.54 (d, J=8.82 Hz, 1 H), 7.80 (dd, J=8.65, 1.87 Hz, 1 H), 8.16(d, J=1.70Hz, 1 H), 8.21 (d, J=9.16Hz, 1 H) ppm; MS (DCI/NH3): nVz 349 (M+H)^ Anal. Calculated for C21H24N40-1.60 CF3CO2H: C, 54.75; H, 4.86; N, 10.55. Found: C, 54.69; H. 4.80; N, 10.58.
Example 7
5-(64(endo)-8-Methvl-8-aza-bicvclo[3.2.1 loct-3-vloxvl-pvridazin-3-vn-2-
trifluoromethyl-1 H-indolc trifluoroacetate
Example 7A 5-(4,4,5,5-Tetramethyl-[l,3,21dioxaborolan-2-yl)-2-trif1uoromethvl-lH-indole A mixture of 5-Bromo-2-trifluoromelhyl-1 H-indolc (Ref. US 2005043347, 6.05 g, 22.9 mmol), bis(pinacolato)diboron (7.74 g, 30.5 mmol), KOAc (8.05 g, 82 mmol) and PdCl2(dppf)'CH2Cl2 (901 mg, 1.1 mmol) in anhydrous DMF (242 mL) were processed according to the procedure of outlined in Example 5 A to provide the titled compound. H NMR (300 MHz, CD3OD) 5 1.36 (s, 12 H), 6.91 (s, 1 H), 7.43 (d, J=8.48 Hz, 1 H), 7.64 (d, J=8.14Hz, 1 H), 8.11 (s, 1 H)ppm; MS (DCI/NHO: 312 (M+H)^
Example 7B (exo)-8-Methvl-8-aza-bicvclo| 3.2.1 |oct-3-vl-4-nitro-benzoate To a mixture of (endo)-tropine (2.82 g, 20.0 mmol). 4-nitrobenzoic acid (3.34 g, 20.0 mmol) and triphenylphosphine (5.24 g, 20.0 mmol) in dry THE (100 mL) at room temperature was added diisopropyl azodicarboxylate (4.04 g, 20.0 mmol) and the resulting mixture stirred for 40 hours. The mixture was concentrated under reduced pressure and the residue purified by chromatography (140 g Si02, ElOAc : MeOH : NH.VH2O, 90:10:1, Rf=0.30) to provide the titled compound. 'H NMR (300 MHz, CD3OD) 6 1.74 - 2.23 (m, 8 H), 2.38 (s, 3 H), 3.32 - 3.38 (m, 2 H), 5.23 - 5.38 (m, 1 H), 8.21 (d, J=8.82 Hz, 2 H), 8.32 (d, J=8.82 Hz, 2 H) ppm; MS (DCI/NH3): 291 (M+H)^
Example 7C (exo)-8-methvl-8-aza-bicvclo| 3.2.1 |octan-3-ol

The product of Example 7B (5.0 g, 0.017 mol) in ethanol (10 mL) was treated with NaOH (IN, 200 mL) at room temperature for 40 hours. The mixture was extracted with the mixture of 10% isopropanol in chloroform (3 X 100 mL) and the combined extracts concentrated under reduced pressure to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 1.55 - 1.69 (m. 4 H), 1.80 (m, 2 H), 1.99 - 2.09 (m. 2 H), 2.28 (s, 3 H), 3.14 - 3.21 (m, 2 H), 3.79 - 3.93 (m, 1 H) ppm. MS (DCI/NH3): 142 (M+H)^
Example 7D (exo)-3-(6-chloro-pyridazin-3-yloxy)-8-methyl-8-aza-bicyclo[3.2.1|octane The product of Example IC (721 mg, 5.1 mmol) and 3,6-dichlropyridazine (1.04 g, 7.0 mmol) were treated according to the procedure outlined in Example 1A to provide the title compound. 'H NMR (300 MHz, CD;,OD) 8 1.87 - 2.07 (m, 4 H), 2.23 - 2.31 (m,
2 H), 2.37 (m, 2 H), 3.60 - 3.69 (m, 2 H), 5.54 (m, 1 H). 7.15 (d, J=9.16 Hz, 1 H), 7.64 (d, J=9.16 Hz, 1 H) ppm; MS (DCI/NH3): 254 (M+H)+
Example 7E 5-(6-[(endo)-8-Methyl-8-aza-bicvclo|3.2.1 |oct-3-yloxv1-pvridazin-3-Yn-2-
trifluoromethyl-1 H-indole trifluoroacetate The product of Example 7D (128 mg, 0.5 mmol) and the product of Example 7A (311 mg, LO mmol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD,OD) 8 2.01 - 2.73 (m, 8 H), 2.85 (s,
3 H), 4.01 -4.10(m. 2H), 5.64-5.80(m, 1 H), 7.02 (s, 1 H), 7.23 (d, J=9.15 Hz, 1 H),
7.60 (d, J=8.48 Hz, 1 H), 7.95 (dd, J=8.48, 1.70 Hz, 1 H), 8.13 (d, J=9.49 Hz, 1 H), 8.26
(d, J=1.02 Hz, 1 H) ppm; MS (DCI/NH3): m/z 403 (M+H)\ Anal. Calculated for
C2iH2iF3N40-1.55CF3C02H: C, 49.98; H, 3.92; N, 9.67. Found: C. 49.93; H, 4.09; N,
9.69.

Example 8 5-|6-|(eA-o)-8-Methvl-8-aza-bicvclo[3.2.1 |oct-3-yloxy|-pvridazin-3-vl)-lH-indole
fumaratc The product of Example 7D (154 mg, 0.61 mmol) and 5-(4.4,5,5-lctramcthyl-[ 1.3,2|dioxaborolan-2-yl)-lH-indolc (Aldrich, 243 mg, 1.0 mmol) were treated with bis(triphenylphosphine)palladium(II) chloride (Aldrich, 7.02 mg, 0.01 mmol) and biphcnyl-2-yl-dicyclohexyl-phosphane (Strem Chemicals. 10.5 mg, 0.03 mmol) in dioxanc/EtOH/ aqeouslM N'd2CO^ (v. 1/1/1,3 niL) were heated and microwaved to 150 °C and 300 watts for 15 minutes in an Emry^*^ Creator microwave. The mixture was cooled to ambient temperature, the solid was filtered off with a syringe filter and the organic solution was directly purified by preparative HPLC (Gilson, Xterra® column, 7 ^m, 40 X 100 mm, eluting solvent, MeCN / H2O (with 0.1 M NH4HCO3/NH4OH, PH=10) (v. 90/10 to 10/90 over 25 minutes), flow rate, 40 mL/min., uv. 254 nm) to provide the free base of the titled compound. The free base was treated with fumaric acid (65 mg, 0.57 mmol) according to the procedure of Example 5C to provide the title compound. H NMR (300 MHz, CD3OD) 8 2.04 - 2.50 (m, 6 H), 2.57 - 2.69 (m, 2 H), 2.85 (s, 3 H), 3.99 - 4.05 (m, 2 H), 5.63 - 5.78 (m, 1 H), 6.56 (d, J=3.05 Hz, 1 H), 6.69 (s, 2 H), 7.20 (d, J=9.15 Hz, 1 H), 7.31 (d, J=3.39 Hz, 1 H), 7.51 (d, J=8.48 Hz. 1 H), 7.74 (dd, J=8.48, 1.70 Hz, 1 H), 8.09 (d, J=9.49 Hz, 1 H). 8.14 (d. J=1.02 Hz. 1 H) ppm; MS (DCI/NH3): m/z 335 (M+H)^; Anal. Calculated for C20H22N4O-1.20 C4H4O4: C, 62.88; H, 5.70; N. 11.83. Found: C, 62.63; H. 5.70; N, 11.96.
Example 9 5-{5-[(endo)-8-Methvl-8-aza-bicvclo|3.2.11oct-3-Yloxvl-pvridin-2-vl}-lH-indole
bistosylate
Example 9A (endo)-3-(6-Chloro-pvi-idin-3-vioxy)-8-mcthyl-8-aza-bicyclol3.2.11octane The mixture of (endo)-tropine (Aldrich, 2.82 g, 20 mmol), 2-chloro-5-iodo-pyridinc (Aldrich, 2.39 g, 24 mmol), Cul (Strem Chemicals, 0.19 g, 1 mmol) and 1,10-phenanthroline (Aldrich, 0.36 g. 2 mmol). C.S2CO3 (Aldrich. 6.52 g. 20 mmol) in toluene

(anhydrous, Aldrich, 25 mL) was stirred at 110 °C for 40 hours. The mixture allowed to cool to ambient temperature and was diluted with CH2CI7 (100 niL) and washed with water (2x10 mL). The organic solution was concentrated and the title compound was purified by chromatography (Si02, CH2CI2: McOH : NHVH2O, 90:10:1, R,. 0.10) to provide the titled compound. 'H NMR (300 MHz. CD3OD) 8 1.97 - 2.08 (d, J=14.5 Hz,, 2 H). 2.13 - 2.18 (d, J=2.37 Hz, 2 H), 2.45 (s, 3 H), 3.35 - 3.41 (m, 2 H), 4.66 (t, J=4.8 Hz, 1 H), 7.35 - 7.42 (m, 2 H), 7.96 - 8.04 (dd, J=2.3, 1.0 Hz, 1 H) ppm. MS (DCI/NH3) m/z 255 iM+U)\ 253 (M+Hf.
Example 9B 5-{5-l(endo)-8-Methvl-8-aza-bicvclo|3.2.1|oct-3-vloxvl-pvridin-2-vl}-lH-indole The mixture of the product from Example 9A (150 mg, 0.59 mmol), 5-indolylboronic acid (Rsycor, 143.3 mg, 0.89 mmol), Pd(PPh3)4 (Aldrich, 6.8 mg, 0.006 mmol) and K2CO3 (2 M, 1 niL) was heated to 85 °C in dioxane(4 mL) for 12 hours. The mixture was cooled to ambient, filtered and purified by preparative HPLC [Waters XTerra RP18 column, 30x100 mm, eluting solvents, MeCN / H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide) (v. 90/10 to 10/90 over 20 min.), flow rate 40 mL/min, uv, 250 nm] to provide the titled compound. 'H NMR (300 MHz, CD3OD) 61.94 - 2.06 (m, 2 H), 2.06 - 2.27 (m, 6 H), 2.34 (s, 3 H), 3.21 |s(br.), 2 H], 4.67 (t, J=4.75 Hz, 1 H), 6.52 (dd, J=3.05, 1.00 Hz, 1 H), 7.26 (d, J=3.39 Hz, 1 H), 7.40 (dd, J=8.82, 3.05 Hz, 1 H), 7.45 (dl, J=8.48. 0.7 Hz, 1 H), 7.63 (dd, J-8.65, 1.87 Hz, 1 H), 7.77 (dd. J=8.82, 0.70 Hz, 1 H), 7.99 - 8.08 (m, 1 H), 8.18 (d, J=3.()5 Hz, 1 H) ppm. MS (DCI/NH3) m/z 334 (M+H)+
Example 9C 5-{5-[(endo)-8-Methyl-8-aza-bicvclo[3.2.1|oct-3-yloxy|-pyridin-2-yll-lH-indole
bistosylatc The product of Example 9B (40 mg, 0.12 mmol) was treated with p-toluene.sulfonic acid monohydrate TsOHHiO (Aldrich, 38 mg, 0.2mmol) in a mixture of 25 % isopropanol in iso-propylacetatc (5 mL) at ambient temperature for 10 hours. The mixture was filtered to provide the titled compound. 'H NMR (300 MHz, CD3OD) 8 2.25-2.56 (m, 13 H), 2.77 - 2.89 (m, 4 H), 3.87 - 4.03 (m, 2 H), 4.90-2.04 (m, IH), 6.66

(dd, J=3.1, 0.7 Hz, 1 H), 7.19 (d, J=8.10 Hz, 4H), 7.43 (d, J=3.39 Hz, 1 H), 7.55 - 7.65 (m. 2 H), 7.68 (d, J=8.14 Hz, 4 H), 8.10 - 8.17 (m, 1 H), 8.22 - 8.38 (m, 2 H), 8.46 (d, J=2.03 Hz, 1 H) ppm. MS (DCI/NH3): m/z 334 (M+H)^ Anal. Calculated for C2iH23N3O-2.05 C7H8SO.v2.OO H2O: C, 57.52; H, 6.17; N, 5.72. Found: C, 57.88; H, 5.99; N, 5.33.
Example 10
(endo)-3-(6-Bcnzo|b|thiophen-5-yl-pyridin-3-vloxy)-8-methyl-8-aza-
bicyclo[3.2.1 loctane bistosylate
Example lOA 2-Benzo|b1thiophen-5-yl-4,4,5,5-tetramethvl-|l,3,21dioxaborolane A mixture of 5-bromo-benzo[b]thiophene (Maybridge. 4.26 g. 0.0200 mol), bis(pinacolato)diboron (Aldrich, 6.09 g, 0.0240 mol) and potassium acetate (Aldrich, 2.94 g, 0.0300 mol) in 1,4-dioxane (Aldrich, 50 mL) was degassed and purged with N2 three times. [l,r-Bis(diphenylphosphino)ferrocene|dichloropalladium(II) PdCl2{dppf)-CH2Cl2 (300 mg, 0.4 mmol, Aldrich) was and the solution was heated to 100°C for 20 hours. The mixture was then cooled to room temperature, diluted with 300 mL of EtOAc and washed with brine (2 x 20 mL). The organic solution was concentrated under reduced pressure and the residue was chromatogi'aphed to provide the title product. 'H NMR (300 MHz, CDCh) 8 1.36 - 1.41 (S, 12 H), 7.35 (d. J=5.50 Hz, 1 H), 7.42(d, J=5.70Hz, 1 H). 7.75 (d, J=8.I4 Hz, 1 H), 7.89 (d, J=8.14 Hz, 1 H), 8.31 (s, 1 H) ppm. MS (DCI/NH3) m/z 278 (M+H)^
Example 108 (endo)-3-(6-Benzo[blthiophen-5-vl-pvridin-3-vloxv)-8-methvl-8-aza-
bicvclof3.2.1 loctane The product from Example 9A (150 mg, 0.59 mmol) and the product of lOA (231.6 mg, 0.89 mmol) was treated with Pd(PPh3)4 (Aldrich, 6.8 mg, 0.006 mmol) according to the procedure of outlined in Example 9B. The title product was purified by preparative HPLC [Waters XTerra RPl 8 column, 30x100 mm, eluting solvents, MeCN / H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium

hydroxide) (v. 90/10 to 10/90 over 20 min.), flow rate 40 niLVmin, uv, 250 nmJ. 'H NMR (300 MHz, CD,OD) S 1.93 - 2.07 (m, 2 H), 2.06 - 2.28 (m, 6 H), 2.34 (s, 3 H), 3.21 [s(br.), 2 HJ, 4.70 (t, J=5.26 Hz, 1 H), 7.37 - 7.50 (m, 2 H). 7.61 (d, J=5.43 Hz, 1 H), 7.80 - 7.92 (m, 2 H), 7.94 - 8.02 (m, 1 H), 8.25 (d, J=2.71 Hz, 1 H), 8.34 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH3) m/z 351 (M+H)^
Example IOC (endo)-3-(6-Benzofb]thiophcn-5-vl-pvridin-3-yloxy)-8-methvl-8-a/a-bicvclol3.2.11octane bistosylate The product of Example lOB (70 mg, 0.20 mmol) was treated with p-toluenesulfonic acid monohydrate TsOHHjO (Aldrich, 38 mg, 0.2mmol) in a mixture of 25% isopropanol in isopropyl acetate as outlined in Exampled 9C. The mixture was filtered to provide the titled compound. 'H NMR (300 MHz, CD3OD) 5 2.35 (s, 6 H), 2.48-2.62 (m, 8 H), 2.78 (s, 3H), 3.88 - 4.05 (m, 2 H), 5.02 (t, J=4.58 Hz, 1 H), 7.22 (d, J=7.80 Hz, 4 H), 7.55 (d, J=5.76 Hz, 1 H), 7.70 (d, J=8.48 Hz, 4 H), 7.75 - 7.84 (m, 2 H), 8.12-8.22(m,2H), 8.29(d,J=9.20Hz, 1 H) 8.37 (d, J=1.70 Hz, 1 H), 8.56 (d, J=3.05 Hz, 1 H) ppm. MS (DCI/NH,): m/z 351 (M+H)^ Anal. Calculated for C2iH2,,N2OS-2.00 C7HxSO3-].00H2O: C, 58.97; H, 5.66; N, 3.93. Found: C, 58.86; H, 5.61; N, 5.7L
Example 11 5-15-1 (exo)-8-Methyl-8-aza-bicyclo|3.2.1 loct-3-vloxy1-pyridin-2-yl}-1 H-indole tosylate
Example llA (exo)-3-(6-Chloro-pvridin-3-vloxv)-8-methvl-8-aza-bicvclo|3.2.Moctanc tosvlatc To the mixture of (endo)-tropinc (Aldrich, 2.82 g. 20 mmol), 2-chloro-5-hydroxy-pyridine (Aldrich, 1.29 g, 10 mmol) and Ph.^P (Aldrich, 5.24 g, 20 mmol) was added di-isopropyl azadicarboxylate (Aldrich, 4.04 g, 20 mmol) in THE (anhydrous, Aldrich, 100 niL) and the mixture was stiired for two days. The mixture was concentrated under reduced pressure and the title product was purified by chromatography (Si02, CH2CI2: McOH : NHvH.O, 90:10:1, Rf. 0.40) as solid (1.98 g. yield, 78.3%). 'H NMR ( 300 MHz , CD3OD) 8 1.63 - 1.92 (m, 4 H). 1.97 - 2.20 (m, 4 H), 2.33 (s. 3 H), 3.34 (s, 2 H), 4.51 - 4.75 (m, 1 H), 7.27 - 7.37 (dd, J=8.8(), 0.7 Hz, 1 H). 7.37 - 7.49 (dd, J=8.80, 3.00

Hz, 1 H), 8.01 (d, J=3.05 Hz, 1 H) ppm. MS (DCI/NHi) m/z 255 (M+H^, 253 (M+Hf.
Example 1 IB 5-{5-r(cxo)-8-Methvl-8-aza-bicvclol3.2.1loct-3-vloxvl-Dvridin-2-vll-lH-indole The mixture of the product irom Example 11A (150 mg, 0.59 mmol), 5-hidolylboronic acid (R.sycor, 143.3 mg, 0.89 mmol) and Pd{PPh3)4 (Aldrich. 6.8 mg, 0.006 mmol) and K2CO3 (2 M, 1 mL) in dioxane(4 mL) was stirred at 85 °C for 12 hours according to the procedure of outlined in Example 9B. The title product was purified by preparative HPLC [Waters XTerra RP18 column, 30x100 mm, eluting solvents, MeCN / H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide) (v. 90/10 to 10/90 over 20 min.), How rate 40 mUmin. uv. 250 nm]. 'H NMR (300 MHz. CD3OD) 8 1.61-1.97 (m, 4 H), 2.00 - 2.23 (m. 4 H), 2.35 (s, 3 H), 3.22 -3.38 (m, 2 H), 4.56 - 4.78 (m, 1 H). 6.51 (d, J=4.07 Hz, 1 H), 7.26 (d, J=3.39 Hz, 1 H), 7.40 - 7.52 (m, 2 H), 7.62 (dd, J=8.48, 1.70 Hz, 1 H), 7.75 (d, J=8.82 Hz, 1 H). 8.03 (s, 1 H), 8.21 (d, J=2.37 Hz, 1 H) ppm. MS (DCI/NH3) m/z 334 (M+H)^
Example 1IC 5-{5-|(exo)-8-Methyl-8-aza-bicvclo[3.2.11oct-3-vloxvl-pvridin-2-vl}-lH-indole tosylate
The product of Example 1 IB (50 mg. 0.15 mmol) was treated with p-toluenesulfonic acid monohydrale TsOHH^O (Aldrich. 38 mg, 0.2mmol) in a mixture of 25% isopropanol in isopropyl acetate (5 mL) at ambient temperature for 10 hours according to the procedure of Example 9C. The mixture was filtered to provide the titled compound. 'H NMR (300 MHz, CD,OD) 5 1.90 - 2.13 (m, 2 H), 2.17 - 2.31 (m, 2 H), 2.33-2.42 (m, 5H), 2.44 - 2.58 (m, 2 H), 2.83 (s, 3 H), 4.02 |s (br.), 2 H|. 4.86 - 5.03 (m. 1 H). 6.53 (dd, J=3.22, 0.85 Hz, 1 H), 7.22 (d, J=8.14 Hz, I H), 7.26 - 7.32 (m, 1 H), 7.47 (d, J=8.48 Hz, 1 H), 7.56 - 7.66 (m, 2H), 7.70 (dt, J=8.10, 1.80 Hz, 2 H), 7.82 (d, J=8.82 Hz. 1 H). 8.05 (d, J=1.36 Hz. 1 H). 8.28 (d. 1:^:3.05 Hz, 1 H) ppm. MS (DCI/NHO: m/z 334 (M+H)^ Anal. Calculated for CaiH.iNiO-1.00 CyHsSOv 1.00 H2O: C, 64.22; H, 6.35; N. 8.02. Found: C, 64.07; H, 6.16; N, 7.69.
Example 12 (exo)-3-[6-(Bcnzofuran-5-vl)-pyridin-3-vloxvl-8-mcthvl-8-aza-bicvclol3.2.1|octane
40

9

bistritluoroacetate The product of Examplel lA (130 mg, 0.52 mmol) and 1-benzoluran-5-ylboronic acid (Maybridge, 166 mg, 1.0 mmol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD^OD) 8 1.98 - 2.58 (m, 8 H), 2.84 (s, 3 H), 3.98-4.09 (m, 2 H), 4.93 - 5.07 (m. 1 H), 6.94 (d, J=1.36 Hz, 1 H), 7.62 (d, J=8.81 Hz, 1 H). 7.73 (dd, J=8.81, 3.05 Hz, 1 H), 7.80 - 7.86 (m, 2 H), 7.92 (d, J=8.48 Hz, 1 H), 8.13(d,J=1.36H7., 1 H), 8.38 (d, J=2.37 Hz, 1 H) ppm; MS (DCI/NH3): m/z 335 (M+H)^ Anal. Calculated for C2iH22N2O2-2.00 CF3CO2H: C, 53.39; H, 4.30; N, 4.98. Found: C, 53.28; H, 4.04; N, 4.95.
Example 13 5-{5-|(exo)-8-Methvl-8-aza-bicvclo|3.2.1 |oct-3-vloxv|-pvridin-2-yll-lH-indazole
hcmifumaratc The product of Example 11A (139 mg, 0.55 mmol) and the product of Example 5A (325 mg, 1.3 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 1.97 - 2.45 (m, 8 H), 2.73 (s, 3 H), 3.80 - 3.89 (m, 2 H), 4.84 - 4.96 (m, 1 H), 6.68 (s, 1 H), 7.56 (dd. J=8.82. 3.05 Hz, 1 H), 7.62 (d, J=8.82 Hz, 1 H), 7.84 (d, J=8.82 Hz, 1 H), 7.97 (dd, J=8.82, 1.70 Hz, 1 H). 8.12 (d, J=1.02 Hz, 1 H), 8.27 (dd, J=1.53, 0.85 Hz, 1 H), 8.32 (d, J=3.()5 Hz. 1 H) ppm; MS (DCI/NH3): m/z 335 (M+H)^
Example 14 5-{ 5-|(exo)-8-Methvl-8-aza-bicvclo[3.2.1 loct-3-vloxvl-pyridin-2-vl 1-2-tritluoromethvl-lH-indole fumarate The product of Example 11A (130 mg. 0.52 mmol) and the product of Example 7A (319 mg. 1.0 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 1.99 - 2.53 (m. 8 H), 2.83 (s, 3 H), 3.96 - 4.03 (m, 2 H), 4.85 - 5.02 (m, 1 H). 6.69 (s. 2 H), 6.97 (s, 1 H), 7.50 - 7.62 (m. 2H), 7.78-7.88(m, 2H), 8.16(d, J=1.36H7.. 1 H), 8.31 (d, J=2.71 Hz, 1 H) ppm; MS (DCI/NH3): m/z 402 (M+H)^ Anal. Calculated for C22H22F3N3O-1.20 C4O4H4: C, 59.53; H, 5.00; N, 7.77. Found: C, 59.26; H, 5.06; N, 7.86.

Example 15 4-{5-[(exo)-8-Methvl-8-aza-bicvclo|3.2.1|oct-3-vloxvl-pvridin-2-vU-lH-indolc
bistrifluoroacetate The product of Example 11A (130 mg, 0.52 mmol) and indole-4-boronic acid (Apollo, 165 mg, 1.0 mmol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD3OD) 6 2.03 - 2.64 (m, 8 H), 2.85(s, 3H), 4.00-4.10(m, 2H), 5.()2-5.16(m, 1 H), 6.70 (d, J=2.37 Hz. 1 H), 7.25-7.40 (m, 2 H), 7.44 (d, J=3.05 Hz, 1 H), 7.59 (d, J=7.80 Hz, 1 H), 8.01 - 8.17 (m, 2 H), 8.50 (d, J=2.71 Hz, 1 H) ppm; MS (DCI/NH3): m/z 334 (M+H)^; Anal. Calculated for C2iH23N^O-2.00C2F.iO2H: C, 53.48; H, 4.49; N, 7.48. Found: C, 53.29; H, 4.17; N, 7.35.
Example 16 4-{5-|(exo)-8-Methyl-8-aza-bicvclo|3.2.1 |oct-3-vloxvl-pvridin-2-yll-phenylamine
bistrifluoroacetate
Example 16A 4-{5-|(exo)-8-Methvl-8-aza-bicvclo|3.2.1|oct-3-vloxvl-pvridin-2-vll-phenvlamine The product of Example 11A (379 mg, 1.5 mmol) and 4-(4,4,5,5-tetramethyl-I l,3,2|dioxaborolan-2-yl)-phenylamine (Aldrich, 552 mg, 2.5 mmol) were processed according to the procedure of Example 58. The mixture was purified by chromatography (140 g Si02, EtOAc : MeOH : NHrH20, 90:10:1) to provide the title compound. 'H NMR (300 MHz, CD3OD) 5 1.76- 1.91 (m, 4 H), 2.08 - 2.21 (m, 4 H), 3.35 - 3.42 [s (br.), 2 H], 4.62 - 4.76 (m. 1 H). 6.73 - 6.81 (m, 2 H), 7.42 (dd, J=8.81, 3.05 Hz, 1 H), 7.57 - 7.68 (m, 3 H), 8.15 (d, J=2.37 Hz, 1 H) ppm; MS (DCI/NH3): m/z 310 (M+H)^
Example 16B 4-i5-l(exo)-8-Methyl-8-aza-bicyclo|3.2.1|ocl-3-yloxyl-pvridin-2-yU-phcnylamine
bistrifluoroacetate The product of Example 16A (135 mg, 0.44 mmol) was repurified by preparative HPLC (Gilson, Xlerra® column, 5 nm, 40 x 100 mm. Eluting Solvent, MeCN / H2O (with 0.1% V. TFA) (v. 90/10 to 10/90 over 25 min.) Flow rate, 40 mLVmin., uv, 254 mn).

The fractions of the desired product were collected and concentrated under reduced pressure and the residue was stin-ed in Ether/Ethanol (v. 10/1, 5 mL) at room temperature for 16 hours. The mixture was filtered to provide the bis tritluoroacetate salt. 'H NMR (300 MHz, CD3OD) 5 1.99 - 2.56 (m, 8 H), 4.03 |s (br.), 2 H], 4.93 - 5.07 (m, 1 H), 6.96 -7.07 (m, 2 H), 7.73 - 7.86 (m, 3 H), 7.88 - 7.98 (m, 1 H). 8.32 (d, J=3.05 Hz. 1 H) ppm; MS (DCI/NH3) m/z 310 (M+Hf; Anal. Calculated for CmH23N3O-2.30 CF3CO2H: C, 49.58; H, 4.46; N, 7.53. Found: C, 49.58; H, 4.36; N, 7.44.
Example 17 5-{6-1 (endo)-8-Methyl-8-aza-bicvclo|3.2.1 |oct-3-vloxvl-pvridin-3-yl}-lH-indole tosylate
Example 17A (endo)-3-(5-Bromo-pyridin-2-yIoxy)-8-methvl-8-aza-hicyclof3.2.1 loctane (endo)-Tropine (Aldrich, 282 mg, 2 mmol) was treated with 'BUOK (Aldrich, 224 mg, 2 mmol) in THF(20 mL) at ambient temperature for 1 hour followed by the addition of 3,6-dibromopyridine (Aldrich, 569 mg, 2.4 mmol). The mixture was stirred at 60°C for additional 10 hours and then concentrated under reduced pressure. The residue was dissolved in CHCiyisopropaiiol (10 : 1, 50 mL) and washed with brine (2 x 5 mL). The organic solution was concentrated under reduced pressure and the title compound was purified by chromatography (SiOj, CH.Cb : MeOH : NHvHzO, 90:10:1, Rf. 0.10). 'H NMR (300 MHz, CD3OD) 8 1.93 (d, J=14.50 Hz, 2 H), 2.02 - 2.23 (m, 6 H), 2.31 (s, 3 H). 3.17|s(br.), 2H], 5.16(t,J=5.26Hz, 1 H), 6.70 (d, J=8.82 Hz, 1 H), 7.77 (dd, J=8.81, 2.71 Hz, 1 H), 8.16 (d, J=2.71 Hz, 1 H) ppm. MS (DCI/NH3): 299 (M+Hf, 297 (M+H)^
Example 17B 5-{6-|(endo)-8-Methyl-8-aza-bicvclo|3.2.1]oct-3-yloxy]-pyridin-3-vU-lH-indole The mixture of the product from Example 17A (150 mg. 0.50 mmol), 5-indolylboronic acid (Rsycor. 121.9 mg, 0.75 mmol), Pd(PPh3)4 (Aldrich. 6.8 mg. 0.006 mmol) and K2CO3 (2 M. 1 mL) in dioxane(4 mL) was stirred at 85 °C for 12 hours according to the procedure of outlined in Example 9B. The title product was purified by preparative HPLC [Waters XTerra RP18 column. 30x100 mm, eluting solvents, MeCN /

H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide) (v. 90/10 to 10/90 over 20 min.), flow rate 40 mL/min. uv, 250 nm]. 'H NMR (300 MHZ, CD3OD) 5 2.01 (d, J=14.30 Hz, 2 H), 2.06 - 2.28 (m, 6 H), 2.34 (s, 3 H), 3.17 - 3.26 (m, 2 H), 5.19 (t, J=5.26 Hz, 1 H), 6.49 (d, J=2.37 Hz, 1 H), 6.82 (d, J=8.48 Hz, 1 H), 7.26 (d, J=3.05 Hz, 1 H), 7.31 (dd, J=8.48, 1.70 Hz, 1 H), 7.45 (d, J=8,48 Hz, 1 H). 7.73 (s, 1 H), 7.96 (dd, J=8.65. 2.54 Hz, 1 H), 8.35 (d, J=2.()3 Hz, 1 H)ppm. MS (DCI/NH3) m/z 334 (M+H)^
Example 17C 5-(6-f(endo)-8-Methvl-8-aza-bicvclo|3.2.1|oct-3-yloxy|-pvridin-3-vl}-lH-indole
bistosylate The product of Example 11B (40 mg, 0.15 mmol) was treated with p-tolucnesulfonic acid monohydrate TSOHH2O (Aldrich, 38 mg, 0.2mmol) in a mixture of 25% isopropanol in isopropyl acetate (5 mL) at ambient temperature for 10 hours according to the procedure outlined in Example 9C. The mixture was filtered to provide the title compound. 'H NMR (300 MHz, CD3OD) 6 2.32-2.58 (m, 14 H), 2.81 - 2.88 (s, 3 H), 3.89 - 4.01 (m, 2 H), 5.27 - 5.41 (m, 1 H), 6.52 (d, J=3.39 Hz, 1 H), 7.13 (d, J=8.48 Hz, 1 H), 7.23 (d, J=7.80 Hz, 4 H), 7.35 (dd, J=8.48, 2.03 Hz, 1 H), 7.49 (d, J=8.48 Hz, 1 H), 7.70 (d, J=8.14 Hz, 4 H). 7.79 (s, 1 H), 8.24 (dd, J=8.65, 2.54 Hz, 1 H), 8.47 (d, J=2.71 Hz. 1 H) ppm. MS (DCI/NH3): m/z 334 (M+H)^ Anal. Calculated for C21H23N3O-2.20 C7HHSO32.00 H2O: C, 58.42; H, 6.01; N, 5.62. Found: C, 58.02; H, 5.84; N, 5.31.
Example 18
(endo)-3-(5-Benzofb|thiophen-5-vl-pvridin-2-vloxv)-8-methvl-8-aza-
bicyclo|3.2.1 loctane tosylate
Example 18A (endo)-3-(5-Benzo[b1thiophen-5-yl-pyridin-2-vloxv)-8-methvl-8-aza-
bicyclo|3.2.1 loctane The mixture of Example 17A (150 mg, 0.50 mmol), the product of Example 10A (197.0 mg, 0.75 mmol), Pd(PPh3)4 (Aldrich, 6.8 mg, 0.006 mmol) and K2CO3 (2 M, 1

mL) in dioxane(4 mL) was processed according to the procedure outlined in Example 9B. The title product was purified by preparative HPLC (Waters XTeita RP18 column, 30x100 mm, eluting .solvents, MeCN / H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide) (v. 90/10 to 10/90 over 20 min.), How rate 40 mlimin, uv, 250 nm]. 'H NMR (300 MHz, CD^OD) 8 1.99 (d, J=14.50 Hz, 1 H), 2.03 - 2.28 (m, 6 H), 2.33 (s, 3 H), 3.14 - 3.25 (m, 2 H), 5.23 (t, J=5.26 Hz, 1 H), 6.86 (d, J=8.48 Hz, 1 H), 7.43 (d, J=5.43 Hz, 1 H), 7.57 (dd, J=8.48, 1.70 Hz, 1 H), 7.61 (d, J=5.43 Hz, 1 H), 7.91 - 8.09 (m, 3 H), 8.42 (d, J=1.70 Hz. 1 H) ppm. MS (DCI/NH3) m/z 351 (M+H)^
Example 18B (endo)-3-(5-Benzorblthiophen-5-yl-pYridin-2-yloxY)-8-methvl-8-aza-bicyclo|3.2.1 loctane tosylate The product of Example 18A (60 mg, 0.17 mmol) was treated with p-lolucnesulfonic acid monohydratc TsOH-H2O (Aldrich, 38 mg, 0.2 mmol) in a mixture of 25% isopropanol in isopropyl acetate (5 mL) at ambient temperature for 10 hours according to the procedure outlined in Example 9C. The mixture was filtered to provide the titled compound. 'H NMR (300 MHz, CD3OD) 8 2.34-2.45 (m, 9 H), 2.48-2.55 (m, 2 H), 2.84 (s, 3 H), 3.88 - 4.00 (m, 2 H), 5.39 (t, J=4.41 Hz, 1 H), 7.06 (d, J=8.82 Hz, 1 H), 7.23 (d, J=7.80 Hz, 2 H), 7.45 (d, J=5.43 Hz, 1 H), 7.59 (dd, J=8.48, 1.70 Hz, 1 H), 7.64 (d, J=5.76 Hz, 1 H), 7.70 (d, J=8.48 Hz, 2 H), 8.00 (d, J=8.48 Hz, 1 H), 8.08 (d. J=1.36 Hz, 1 H), 8.18 (dd, J=8.82, 2.37 Hz, 1 H), 8.51 (d, J=2.03 Hz, 1 H) ppm. MS (DCI/NH,): m/z 351 (M+H)^ Anal. Calculated for C.iHj^N.OS-1.10 CyHsSOv 1.00 H2O: C, 61.79; H, 5.93; N, 5.02. Found: C, 61.44; H, 5.63; N, 4.68.
Example 19 5-{6-|(exo)-8-Methvl-8-aza-bicyclol3.2.1loct-3-vloxvl-pyridin-3-vll-lH-indolefumarate
Example 19A (exo)-3-(5-Bromo-pvridin-2-vloxv)-8-methvl-8-aza-bicvclo[3.2.1 loctane The product of Example IC (721 mg, 5.1 mmol) and 2,5-dibromopyridine (1.66

g, 7.0 mmol) were treated according to the procedure outlined in Example lA to provide the title compound. 'H NMR (300 MHz, CD3OD) 5 1.88 - 2.47 (m, 8 H), 2.74 (s, 3 H), 3.82 - 3.90 (m, 2 H), 5.34 - 5.48 (m, 1 H), 6.71 (d, J=8.82 Hz, 1 H), 7.78 (dd, J=8.82, 2.71 Hz, 1 H), 8.20 (d, J=2.37 Hz, 1 H) ppm; MS (DCI/NH3): 2997 (M+H)^ 297 (M+Hf.
Example 19B 5-{6-[(exo)-8-Methyl-8-aza-bicvclo[3.2.1 |oct-3-yloxyl-pyridin-3-yll-lH-indole tumaratc
The product of Example 19A (129 mg, 0.434 mmol) and 5-indolylboronic acid (165 mg, 1.02 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 1.97 - 2.12 (m, 2 H), 2.20 -2.46 (m, 4 H), 2.48 - 2.60 (m, 2 H), 2.84 (s, 3 H), 3.96 - 4.07 (m, 2 H), 5.43 - 5.60 (m, 1 H). 6.49 (d, J=3.05 Hz, 1 H), 6.70 (s, 2 H), 6.82 (d, J=8.48 Hz, 1 H), 7.23 - 7.35 (m, 2 H), 7.46 (d, J=8.14 Hz, 1 H), 7.73 (d, J=1.70 Hz, 1 H), 7.95 (dd, J=8.65, 2.54 Hz, 1 H), 8.37 (d, J=2.03 Hz, 1 H) ppm; MS DCUNHO: m/z 334 (M+H)^ Anal. Calculated for C21H23N3OI.IOC4O4H4I.OOH2O: C, 63.67: H, 6.18; N, 8.77. Found: C, 63.77; H, 6.26; N, 8.64.

Example 20 |6-(lH-Indol-5-vl)-pvridin-3-vll-l(endo)-8-methvl-8-aza-bicvclol3.2.1|oct-3-vl|-amine
bis( hydrochloride)
Example 20A (6-Chloro-pyridin-3-yl)-[(endo)-8-methvl-8-aza-bicvclo|3.2.11oct-3-yl]-amine A mixture of tropinone (Aldrich, 2.78 g, 20 mmol), 6-chloro-pyridin-3-ylaminc (Aldrich, 2.83 g, 22 mmol), Na2S04 (anhydrous, Aldrich, 21.3 g, 150 mmol) and NaBH(0Ac)3 (Aldrich, 8.48 g, 40 mmol) in HOAc (50 mL) at ambient temperature was stirred for 15 hours. The mixture was filtered and the filtrate washed with EtOH (2 x 10 mL). The organic solution was concentrated under reduced pressure and the title compound obtained by purified using chromatogiaphy (SiOi, CH2CI2: MeOH : NHrH20, 90:10:2, Rf. 0.10). 'H NMR (300 MHz, CD3OD) 6 2.16 (d, J=15.26 Hz, 2 H), 2.25 - 2.35 (m, 2 H), 2.37 - 2.60 (m, 4 H), 2.81 (s, 3 H), 3.65 (t, J=5.93 Hz, 1 H), 3.79 -3.98 (m, J=2.71 Hz, 1 H), 7.09 (dd, J=8.50, 3.00 Hz, 1 H), 7.21 (d, J=8.80Hz, 1 H), 7.73 (d, J=2.71 Hz, 1 H)ppm. MS (DCI/NH3) m/z 254 (M+H)^ 252 (M+H)^
Example 20B |6-(lH-Indol-5-vl)-pyridin-3-yll-|(endo)-8-mcthyl-8-aza-bicvclo|3.2.11oct-3-vll-amine The mixture of Example 20A (250 mg, 1.0 mmol), 5-indolylboronic acid (Rsycor, 241.0 mg, 1.50 mmol), bis(triphenylphosphine)palladium(II) chloride (Aldrich, 10.0 mg, 0.01 mmol) and biphenyl-2-yl-dicyclohexyl-phosphane (Strem Chemicals, 11.0 mg, 0.03 mmol) in dioxane/EtOH/ IM aqueous Na2C0:i (v. l/I/l 3 mL) were heated and microwaved to 130 °C and 300 watts for 15 minutes in an Emry™ Creator microwave. The mixture was filtered through a syringe filter and the liquid was purified by preparative HPLC [Waters XTerra RP18 column, 30x100 mm. eluting solvents, MeCN / H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide) (v. 90/10 to 10/90 over 20 min.), flow rate 40 mUmin, uv. 250 nm| to provide the titled compound. 'H NMR (300 MHz. CD,OD) 5 1.88 (d, J= 15.20 Hz, 2 H) 2.05 -2.18 (m, 4 H), 2.18 - 2.31 (m. 2 H), 2.37 (s, 3 H), 3.26 |s (br.), 2 H)|, 3.60 (t, J=6.44 Hz, I H), 6.49 (d, J=3.05 Hz, 1 H), 7.05 (dd, J=8.82. 2.71 Hz. 1 H), 7.24 (d, J=3.05 Hz, 1 H),
47

7.42 (d,.J=8.48 Hz, 1 H), 7.49 - 7.64 (m. 2 H), 7.95 (s, 1 H) ppm. MS (DCI/NHO m/z 333 (M+Hf.
Example 20C |6-(lH-Indol-5-vl)-pvridin-3-vl|-[(cndo)-8-mcthvl-8-aza-bicvclo|3.2.noct-3-vl|-amine
bis( hydrochloride) The solution of Example 20B (160 mg, 0.48 mmol) in EtOAc (10.0 mL) at ambient temperature was treated with 4M hydrochloric acid in dioxane (0.5 mL, 2.0 mmol) for 10 hours. The title compound was obtained by filtration. 'H NMR (300 MHz, CD:,OD) 6 2.25 (d, J=15.65 Hz, 2 H), 2.32 - 2.53 (m, 4 H). 2.54 - 2.64 (m, 2 H), 2.84 (s, 3H), 3.83(t,J=6.14Hz, 1 H), 3.97 |s (br.), 2 H|, 6.63 (d, J=3.07 Hz, 1 H), 7.40-7.41 (m, 1 H), 7.54 (dd, J=8.60, 1.90Hz, 1 H), 7.62 (d, J=8.60 Hz, 1 H). 7.83 - 7.95 (m, 2 H), 8.06 (d, J=1.53 Hz, 1 H), 8.12 (d, J=8.90 Hz, 1 H) ppm. MS (DCI/NH3): nVz 333 (M+Uf. Anal. Calculated for C21H24N4 • 2.30 HCl- 3.35 H2O: C, 52.92; H, 6.98; N, 11.75. Found: C, 52.87; H, 6.78; N, 11.35.
Example 21 |6-(Benzofuran-5-yl)-pyridin-3-yll-|(endo)-8-methyl-8-aza-bicvclol3.2.1 |oct-3-yl|-amine
fumarate The product of Example 20A (136 mg, 0.54 mmol) and l-bcnzofuran-5-ylboronic acid (Aldrich, 185 mg, 1.14 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.14- 2.57 (m, 8 H). 2.83 (s, 3 H), 3.74 (t, J=5.93 Hz, 1 H), 3.90 |s (br.), 2 H|, 6.69 (s, 2 H), 6.89 (d, J=1.36 Hz, 1 H), 7.13 (dd, J=8.65, 2.88 Hz, 1 H), 7.54 (d, J=8.82 Hz, 1 H), 7.68 (d, J=8.82 Hz, 1 H), 7.72 - 7.79 (m, 2 H), 7.99 - 8.07 (m, 2 H) ppm; MS DCI/NH3): nVz 334 (M+Hf.

Example 22 l(endo)-8-Methvl-8-aza-bicvclol3.2.1loct-3-Yll-|6-(2-trit1uoroinethvl-lH-indol-5-vl)-
pyridin-3-yl|-aminc histrifluoroacetate The product of Example 20A (130 mg, 0.52 mmol) and the product of Example 7A (262 mg, 0.84 mmol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.17 - 2.62 (m, 8 H), 2.84 (s, 3 H), 3.82 (t, J=:5.93 Hz, 1 H), 3.96 |s (br.), 2 H], 7.06 (s, 1 H), 7.63 - 7.80 (m, 3 H), 7.95 (d, J=2.71 Hz, 1 H), 8.06 (d, J=9.16 Hz, 1 H), 8.15 (d, J=1.36 Hz, 1 H) ppm; MS DCI/NH3): m/z 401 (M+Hf; Anal. Calculated for C22H22F3N3O • 2.00 CF3CO2H • 0.70 NH4OH: C, 47.75; H, 4.24; N, 7.92. Found: C, 47.69; H. 3.91; N, 8.14.
Example 23 16-( 1 H-lndazol-5-yl )-pyridin-3-yll-| (endo)-8-methvl-8-aza-bicyclo| 3.2.1 loct-3-vl l-amine
fumurate The product of Example 20A (128 mg, 0.51 mmol) and the product of Example 5A (205 mg, 0.84 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.11 - 2.55 (m, 8 H), 2.79 (s, 3 H), 3.73 (t, J=5.93 Hz, 1 H), 3.85 |s (br.), 2 H], 6.67 (s, 3 H), 7.13 (dd, J=8.65, 2.88 Hz, 1 H), 7.59 (d, J=8.82 Hz. 1 H), 7.70 (d, J=8.82 Hz, 1 H), 7.90 (dd, J=8.82, 1.70 Hz, 1 H), 8.04 (d, J=2.71 Hz, 1 H), 8.09 (s, 1 H), 8.18 (s, 1 H) ppm; MS DCI/NH3): m/z 334 (M+H)^; Anal. Calculated for C2oH23Ny 1.50 C404H4- I.OONH4OH: C, 57.55; H, 6.32; N, 15.49. Found: C, 57.46; H, 6.26; N, 15.55.
Example 24 |6-(lH-lndol-4-vl)-pvridin-3-vl|-[(endo)-8-methvl-8-aza-bicvclol3.2.1|oct-3-vl1-amine
fumarate The product of Example 20A (130 mg, 0.52 mmol) and indole-4-boronic acid (Apollo, 165 mg, 1.0 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.16 - 2.60 (m, 8 H), 2.84 (s, 3 H). 3.76 (t, J=5.76 Hz, 1 H), 3.88 - 3.95 |s (br.), 2 Hj, 6.69 (s, 2 H), 6.70 (d, J=3.39 Hz, 1 H), 7.14 - 7.32 (m, 4 H), 7.40 (d, J=7.80 Hz, 1 H), 7.68 (d, J=8.48 Hz, 1 H),

8.06 (d, J=2.71 Hz, 1 H) ppm; MS DCI/NH3): m/z 333 (M+Hf; Anal. Calculated for C2iH24N4-1.40C4O4H4-0.90H2O: C, 62.50; H, 6.19; N, 10.96. Found: C, 62.40; H, 6.17; N, 11.04.
Example 25 |(endo)-8-aza-bicyclo|3.2.1|oct-3-vll46-(lH-indol-5-yl)-pyridm-3-yl|-aminc
Example 25A (cndo)-3-(6-Chloro-pyridin-3-ylamino)-8-aza-bicvclo|3.2.1]octane|-8-carboxylic acid
tert-butyl ester The mixture of 3-oxo-8-aza-bicyclo[3.2.1|octane-8-carboxylic acid tert-butyl ester (Fluka, 3.50 g, 15.50 mmol), 6-chloro-pyridin-3-ylamine (Aldrich, 2.20 g, 17.1 mmol), Na2S04 (anhydrous, Aldrich, 16.6 g, 116 mmol) and NaBH(0Ac)3 (Aldrich, 6.59 g, 31.1 mmol) in HOAc (40 mL) was stin-ed at ambient temperature for 15 hours according to the procedure outlined in Example 20A. The title compound was purified by chromatography (SiOa, hexane : EtOAc, 50 : 50, R,. 0.40). 'H NMR (300 MHz, CD30D)5 1.41- 1.56 (m, 9 H), 1.58 - 2.90 (m, 8 H) 4.13 - 4.33 (m, 1 H), 4.37 - 4.54 (m, 2 H), 7.00 (dd, J=8.81, 3.05 Hz, 0.5 H), 7.15 (d, J=8.14 Hz, 0.5 H), 7.26 (dd, J=8.30, 3.10 Hz, 0.5 H) 7.41 (d, J=8.48 Hz, 0.5 H), 7.68 (d, J=3.05 Hz, 0.5 H) 7.84 (d, J=2.37 Hz, 0.5 H) ppm. MS (DCI/NH3) m/z 340 (M+H)^ 338 (M+H)^
Example 25B Kendo)- 8-Aza-bicvclo|3.2.l1oct-3-vl|-(6-chloro-pvridin-3-vl)-amine The product of Example 25A (2.92 g, 8.7 mmol) was treated with trifluoroacetic acid (5 mL) in dichloromethane (20 mL) at ambient temperature for 4 hours. The mixture was concentrated under reduced pressure and the residue purified by chromatography (Si02, CH2CI2: MeOH ; NHVH2O, 90:10:2, R,. 0.10) to provide the title compound, 'H NMR (300 MHz, CD3OD) 8 1.71-1.94 (m, 4 H) 2.03 - 2.22 (m, 4 H), 3.42 - 3.64 (m, 3 H), 6.98 (dd, J=8.82, 3.05 Hz, 1 H), 7.14 (d, J=8.14 Hz, 1 H), 7.65 (d, J=3.05 Hz, 1 H) ppm. MS (DCI/NH3) m/z 238 (M+H)^ 240 (M+H)^
Example 25C

|(endo)-8-aza-bicvclol3.2.11oct-3-vl|-|6-(lH-indol-5-vl)-pyridin-3-vl|-amine The product of Example 20A (250 mg, 1.0 mmol), 5-indolylboronic acid (Rsycor, 241.0 mg, 1.50 mmol), bi.s(triphenylphosphine)palladium{II) chloride (Aldrich, 10.0 mg, 0.01 mmol) and biphenyl-2-yl-dicyclohcxyl-phosphanc (Slrem Chemicals, 11.0 mg, 0.03 mmol) in dioxanc/EtOH/ IM aqueous Na2C03 (1/1/1 3 niL) were heated and microwaved to 130 °C and 300 watts for 15 minutes in an Emry^'^^ Creator microwave. The solid was filtered off with a syringe filter and the liquid was purified by preparative HPLC [Waters XTerra RP18 column, 30x100 mm, eluting solvents, McCN / H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide) (v. 90/10 to 10/90 over 20 min.), flow rate 40 niL/min, uv, 250 nm] to provide the titled compound. 'H NMR (300 MHz, CD3OD) 8 1.96-2.17 (m, 4 H), 2.20 - 2.52 (m, 4 H), 3.71 (t, J=6.1 Hz, 1 H) 3.80 - 3.92 (m, 2 H), 6.49 (d, J=2.37 Hz, 1 H), 7.10 (dd, J=8.82, 3.05 Hz, 1 H), 7.25 (d, J=3.05 Hz, 1 H), 7.42 (d. J=8.48 Hz, 1 H), 7.56 (dd, J=8.48, 1.70 Hz, 1 H), 7.63 (d, J=8.48 Hz, 1 H), 7.92 - 8.00 (s, 1 H) ppm. MS (DCI/NH,) m/z 319 (M+H)^
Example 26 |6-(4-Amino-3-methyl-phenyl)-pvridin-3-yl|-|(endo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-
yl I-amine fumarate
Example 26A [2-methyl-4-(4,4,5,5-tetramethvl-|l,3.2|dioxaborolan-2-yl)-phenyll-trifluoroacctamide A mixture of N-(4-Bronio-2-methyl-phenyl)-2,2,2-tritluoro-acetamide (ref. US 2005-0043347, 4.23 g, 15.0 mmol), bis(pinacolato)diboron (Aldrich, 5.07 g, 20 mmol), KOAc (Aldrich, 5.27 g, 53.7 mmol) and PdCl2(dppf):CH:Cl2 (Aldrich, 203 mg, 0.25 mmol) in anhydrous dioxane (50 mL) at 100°C for 72 hours. The mixture was cooled to ambient temperature, diluted with EtOAc (150 mL), washed with water (2 x 25 mL). The organic solution was concentrated under reduced pressure and the residue was purified by chromatography (140 g Si02, hexane : EtOAc. 80:20, R|. 0.6) to provide the titled compound. 'H NMR (300 MHz, CDCI3) 8 1.35 (s, 12 H), 2.31 (s, 3 H), 7.66 - 7.80 (m. 3 H), 7.90 (d, J=8.14 Hz, 1 H) ppm; MS (DCI/NH3): 347 (M+NH4)^
Example 26B

|6-(4-Amino-3-niethyl-phenvl)-pvridin-3-vl|-|(endo)-8-methvl-8-aza-bicyclo[3.2.1|oct-3-
ylj-amine fumarate The product of Example 20A (130 mg, 0.52 mmol) and the product of Example 26A (277 mg, 0.84 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound, 'H NMR (300 MHz, CD3OD) 8 2.12 - 2.57 (m, 11 H), 2.82 (s, 3 H), 3.71 (t, J=6.10 Hz, 1 H), 3.85 - 3.94 (m, 2 H), 6.69 (s. 2 H), 6.77 (d, J=8.14 Hz, 1 H), 7.10 (dd, J=8.65, 2.88 Hz, 1 H), 7.42 (dd, J=8.14. 2.37 Hz, 1 H), 7.47 (s, I H), 7.53 (d. J=8.82 Hz, 1 H) ,7.92 (d, J=2.7l Hz, 1 H) ppm; MS DCI/NH3): m/z 323 (M+H^.
Example 27 l4-(lH-Indol-5-vl)-phenvH-l(endo)-8-methvl-8-aza-bicyclo[3.2.11oct-3-yl|-amine
fumarate
Example 27A (4-Bromo-phenyl)-(3-endo-8-methyl-8-aza-bicvclo|3.2.1 |oct-3-vl)-amine Tropinone (Aldrich, 2.78 g, 20 mmol) and p-bromoaniline (Aldrich, 3.78 g, 22 mmol) were treated according to the procedure outlined in Example 20A to provide the title compound. The title compound was purified by chromatography (140 g SiOi, EtOAc: MeOH (v. 2% NH3.H2O), 50:50, R|. 0.25). 'H NMR (300 MHz. MeOH-D4) 5 1.71-1.82 (m, 2 H), 2.00 - 2.22 (m, 6 H), 2.29 (s, 3 H), 3.14 |s (br.), 2 HI, 3.46 (t, J=6.61 Hz, 1 H), 6.46 (d, J=8.81 Hz, 2 H), 7.17 (d, J=9.15 Hz, 2 H)ppm; MS (DCI/NH3): 297 (M+H)^ 295 (M+H)^
Example 27B f4-(lH-lndol-5-vl)-phenvl|-[(endo)-8-methvl-8-aza-bicyclo[3.2.1]oct-3-vl|-amine
fumarate The product of Example 27A (134 mg. 0.45 mmol) and 5-(4,4,5,5-lelramethyl-I l,3,21dioxaborolan-2-yl)-lH-indole (Aldrich, 198 mg, 0.81 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. H NMR (300 MHz, CD3OD) 8 2.16 - 2.60 (m, 8 H), 2.82 (,s. 3 H). 3.72 (t. J=5.76 Hz. 1 H). 3.89 Is (br.). 2 H|, 6.44 (d, J=2.37 Hz, 1 H), 6.66 - 6.74 (m. 5.3 H), 7.21 (d, J=3.39 Hz, 1 H), 7.26 - 7.32 (m, 1 H), 7.35 - 7.41 (m, 1 H), 7.46 (d, J=8.82 Hz, 2 H), 7.67 (d, J=1.02

Hz, 1 H) ppm; MS DCI/NH3): m/z 332 (M+H)^; Anal. Calculated for C22H2sNvl.65 C4O4H4: C, 65.68; H, 6.09; N, 8.03. Found: C, 65.62; H. 6.40; N, 8.14.
Example 28 |4-(lH-Indazol-5-vl)-phenvll-[(endo)-8-mclhvl-8-aza-bicvclo[3.2.1|oct-3-vl|-aminc
fumarate The product of Example 27A (134 mg, 0.45 mmol) and the product of Example 5A (265 mg. 1.08 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz. CD,,OD) 5 2.14- 2.61 (m, 8 H). 2.82 (s, 3 H), 3.72 (t, J=5.93 Hz, 1 H), 3.89 |s (br.). 2 H|, 6.67 - 6.77 (m, 5 H), 7.45 - 7.52 (m, 2 H), 7.52 - 7.58 (m, 1 H), 7.59 - 7.65 (m, 1 H), 7.87 (s, 1 H), 8.04 (s. 1 H) ppm; MS DCI/NH3): m/z 333 (M+H)^ Anal. Calculated for C2iH24N4-1.48 C4O4H4: C, 64.12; H, 5.98; N, 11.11. Found: C, 64.00; H, 5.98; N, 11.22.
Example 29 Kendo )-8-Methvl-8-aza-bicvclol3.2.1loct-3-vl|-|4-(l-methvl-lH-indol-5-vl)-phenYll-
amine fumarate The product of Example 27A (128 mg. 0.43 mmol) and N-methylindole-5-boronic acid (Frontier. 142 mg, 0.81 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz. CD3OD) 8 2.12 - 2.63 (m. 8 H), 2.82 (s. 3 H). 3.72 (t. J=5.93 Hz, 1 H), 3.80 (s, 3 H), 3.88 |s (br.). 2 H], 6.42 (d, J=3.05 Hz, 1 H), 6.66 - 6.74 (m, 4 H). 7.13 (d, J=3.()5 Hz, 1 H), 7.36 (d, J=1.0 Hz, 2 H), 7.46 (d, J=8.48 Hz, 2 H), 7.67 (t, J=1.20 Hz, 1 H) ppm; MS DCI/NH3): m/z 346 (M+H)^ Anal. Calculated for C23H27N3-1.10 C4O4H4: C, 69.55; H, 6.69; N, 8.88. Found: C, 69.29; H. 6.76; N, 8.85.

Example 30 (4-Benzo|b|thiophen-5-vl-phenvl)-r(endo)-8-i-nethvl-8-aza-bicvclol3.2.1|oct-3-vl|-amine
trifluoioacctalc The product of Example 27A (129 mg, 0.44 mmol) and 2-bcnzo|b|thiophen-5-yl-4,4,5,5-tetramcthyl-[l,3,2]dioxaborolane (Maybridgc, 189 mg, 0.73 mmol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD^OD) 8 2.17 - 2.60 (m, 8 H), 2.82 (s. 3 H), 3.73 (t, J=5.76 Hz, 1 H), 3.90 [s (br.), 2 H|, 6.73 (d, J=8.82 Hz, 2 H), 7.38 (d, J=5.76 Hz, 1 H), 7.48 - 7.59 (m, 4 H), 7.88 (d, J=8.48 Hz, 1 H), 7.97 (d, J=1.70 Hz, 1 H) ppm; MS DCI/NH3): m/z 349 (M+H)^ Anal. Calculated for C22H24N2S-1.10 C2F3O2H: C, 61.33; H, 5.34; N, 5.91. Found: C, 61.03; H, 5.34; N, 5.76.
Example 31 |4-(Benzofuran-5-yl)-phenvl1-|(endo)-8-methyl-8-aza-bicyclo[3.2.1|oct-3-yl|-amine
fumarate The product of Example 27A (135 mg, 0.46 mmol) and 5-(4,4,5,5-tetramethyl-I l,3,2]dioxaborolan-2-yl)-benzofuran (Maybridge, 189 mg, 0.77 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. H NMR (300 MHz, CD3OD) 8 2.15 - 2.60 (m, 8 H), 2.82 (s. 3 H), 3.72 (t, J=5.93 Hz, 1 H), 3.88 Is (br.), 2 H], 6.65 - 6.76 (m, 4 H), 6.83 (d, J=2.71 Hz. 1 H), 7.40 - 7.52 (m, 4 H), 7.69 - 7.75 (m, 2 H) ppm; MS DCI/NH3): nVz 333 (M+H)^ Anal. Calculated for C22H24N20-1.15C404H4: C, 68.57; H, 6.19; N, 6.01. Found: C, 68.42; H, 6.17; N, 6.02.
Example 32 |4-(lH-hidol-4-yl)-phenvll-[(endo)-8-methyl-8-aza-bicyclol3.2.1]oct-3-vll-amine
fumarate The product of Example 27A (125 mg, 0.42 mmol) and indole-4-boronic acid (Apollo, 131 mg, 0.81 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 5 2.11 - 2.68 (m. 8H). 2.83(s, 3H), 3.74(t,J=8.31 Hz, 1 H), 3.89 |s (br.), 2 H] 6.58 (dd, J=3.39, 1.02 Hz, 1 H), 6.68 (s, 2 H), 6.74 (d, J=8.82 Hz, 2 H), 6.99 (dd, J=7.12, 1.02 Hz, 1 H), 7.08 -

7.15 (m, 1 H), 7.23 (d, J:=:3.39 Hz, 1 H), 7.29 (d. J=8.14 Hz. 1 H). 7.51 (d. J=8.81 Hz. 2 H) ppm; MS DCI/NH3): m/z 332 (M+Hf; Anal. Calculated for C22H25NV 1.00 C4O4H4: C. 69.78; H, 6.53; N. 9.39. Found: C. 70.17; H. 6.69; N. 9.58.
Example 33 [3-( lH-Indol-5-yl)-phenyI]-[(cndo)-8-methyl-8-aza-bicyclo|3.2.1 loct-3-yl1-aminc
fumarate
Example 33A (3-Bromo-phenyl)-[(endo)-8-methyl-8-aza-bicyclo[3.2.1|oct-3-yll-amine Tropinone (696 mg, 5.0 mmol) and m-bromoaniline (946 mg, 5.5 nimol) were treated according to the procedure outlined in Example 20A to provide the title compound. The title compound was purified by chromatography 1140 g SiO^, EtOAc: MeOH (v. 2% NH3.H2O), 50:50, R,=0.25|. 'H NMR (300 MHz, MeOH-D4) 8 1.72 - 2.23 (m. 8 H), 2.29 (s, 3 H), 3.14 |s (br.), 2 HI. 3.47 (t, J=6.44 Hz. 1 H). 6.46 - 6.52 (ddd, J=8.20, 2.00, 1.00 Hz, 1 H), 6.64 - 6.72 (m. 2 H). 6.92 - 7.02 (t. J=8.10 Hz, lH)ppm;MS (DCI/NH3): 297 (M+H)^ 295 (M+Hf.
Example 33B |3-(lH-lndol-5-yl)-phenvl1-[(endo)-8-methYl-8-aza-bicyclo|3.2.l |oct-3-vl|-amine
fumarate The product of Example 33A (128 mg, 0.43 mmol) and indole-5-boronic acid (165 mg, 1.0 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz. CD3OD) 8 2.19 - 2.61 (m, 8 H). 2.81 (s, 3 H). 3.75 (t. J=5.76 Hz. 1 H), 3.83 - 3.92 (m. 2 H). 6.47 (dd. J=3.()5. 0.70 Hz, 1 H). 6.55 (ddd, J=7.1(), 2.60, 0.70 Hz, 1 H), 6.68 (s, 2 H), 6.89 (t. J=2.03 Hz. 1 H). 6.96 (ddd. J=7.80. 1.70, 1.00 Hz. 1 H). 7.20 (t. J=7.80 Hz. 1 H). 7.24 (d. J= 7.10 Hz. IH). 7.34(dd. J=8.5(), 1.70 Hz. 1 H). 7.39 (I, J=8.40 Hz.l H), 7.74 (dd. J=1.70. 0.70 Hz 1 H) ppm; MS DCI/NH3): m/z 332 (M+H)^; Anal. Calculated for C22H25N3-1.10 C4 H4O4'0.40 C4H8O2: C. 68.03; H, 6.65; N. 8.50. Found: C, 67.68; H, 6.85; N, 8.78.

Example 34 |3-(lH-Indol-4-vl)-phenvl]-l(endo)-8-mcthyl-8-a/a-hicvclo|3.2.11oct-3-yl|-aminc
trifluoroacetate The product of Example 33A (128 mg, 0.43 mmol) and indolc-4-boronic acid (Apollo, 168 mg, 1.0 mmol) were treated according to the procedure outlined in Example IB to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.22 - 2.64 (m, 8 H), 2.81 (s, 3 H), 3.74 (t, J=5.42 Hz, 1 H), 3.87 - 3.93 (m, 2 H). 6.57 - 6.67 (m, 2 H), 6.92 (t, J=2.10Hz, 1 H), 6.99 (dt, J=7.8(), 1.00 Hz, 1 H) 7.14 (t. J=7.56 Hz, 1 H), 7.21 - 7.28 (m,
2 H), 7.35 (d. J=8.14 Hz, 1 H) ppm; MS DCI/NH3): m/z 332 (M+H)^ Anal. Calculated
for C22H2.sNvl.lO CF3CO2H 0.60 EtOH: C, 62.96; H, 6.18; N. 8.67. Found: C, 62.85;
H. 5.98; N, 8.65.
Example 35 5-{6-[(endo)-8-Methyl-8-aza-bicyclo|3.2.1 |oct-3-yloxyl-pyridazin-3-yl}-2-
triffuoromethvl-1 H-indole trifluoroacetate The product of Example 1A (89 mg, 0.35 mmol) and the product of Example 7A (299 mg, 0.96 mmol) were treated according to the procedure outlined in Example 1B to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.22 - 2.67 (m, 8 H), 2.86 (s,
3 H), 3.93 - 4.01 |s (br), 2 H|, 5.55 - 5.62 (ni, 1 H), 7.02 (t. J=1.02 Hz, 1 H), 7.32 (d,
J=9.15Hz, 1 H), 7.60(d, J=8.81 Hz, 1 H), 7.94 (dd, J=8.82. 1.70 Hz, 1 H), 8.16(d,
J=9.49 Hz, 1 H), 8.26 (d, J=l .36 Hz, 1 H) ppm; MS DCI/NH,): m/z 403 (M+H)^ Anal.
Calculated for C21H21F3N4OI.53CF3CO2H: C, 50.09; H. 3.94; N, 9.71. Found: C,
50.07; H, 3.94; N, 9.66.
Example 36 4-{6-f(exo)-8-Methyl-8-aza-bicyclof3.2.1|oct-3-yloxy|-pvridazin-3-yll-lH-indole
fumarate The product of Example 7D (129 mg, 0.51 mmol) and indole-4-boronic acid (Apollo, 161 mg, 1.0 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD,OD) 8 2.05 - 2.50 (m, 6 H),
2.66 (ddd, J=14.92. 5.76, 3.05 Hz, 2 H), 2.85 (s, 3 H). 4.03 (dd, J=3.73, 3.05 Hz, 2 H),
5.66 - 5.83 (m, 1 H), 6.79 (dd, J=3.22, 0.85 Hz, 1 H), 7.22 - 7.30 (m, 2 H), 7.37 (d.

J=3.05 Hz, 1 H), 7.41 (dd, J=7.29, 0.85 Hz, 1 H), 7.54 (d, J=8.14 Hz, 1 H), 8.08 (d, J=9.15 Hz, 1 H) ppm; MS DCI/NH3): nVz 335 (M+H)^; Anal. Calculated for C2()H22N4O.1.20 C4H4O4: C, 62.88; H, 5.70; N, 11.83. Found: C, 62.90; H, 5.53; N, 11.79.
Example 37 5-{6-[(cxo)-8-Methyl-8-aza-bicyclo|3.2.11oct-3-yloxy|-pvridin-3-yll-lH-indole fumaratc
Example 37A (exo)-3-(5-Bromo-pvridin-2-yloxv)-8-methvl-8-a7.a-bicvclo[3.2.1 loctane The product of Example IC (721 mg, 5.1 mmol) and 2,5-dibromo-pyridine (Aldrich, 1.66 g, 7.0 mmol) were treated according to the procedure outlined in Example 1A to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 1.90 - 2.46 (m, 8 H), 2.74 (s, 3 H), 3.81 - 3.90 (m, 2 H), 5.34 - 5.48 (m, 1 H), 6.71 (d, J=8.82 Hz, 1 H), 7.78 (dd, J=8.82, 2.71 Hz, 1 H), 8.20 (d, J=2.37 Hz, 1 H) ppm; MS DCI/NH,): m/z 299 (M+H)^297(M+H)^
Example 37B 5-{6-|(exo)-8-Methyl-8-aza-bicvclo|3.2.1 |oct-3-vloxy|-pvridin-3-vll-lH-indole tumarate
The product of Example 37A (129 mg, 0.43 mmol) and indolc-5-boronic acid (Ryscor Inc., 165 mg, 1.0 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 1.96 - 2.62 (m, 8 H), 2.84 (s, 3 H), 3.97 - 4.04 (m, 2 H), 5.44 - 5.58 (m, 1 H), 6.49 (dd, J=3.22, 0.85 Hz. 1 H), 6.70 (s, 2 H), 6.82 (d, J=8.48 Hz, 1 H), 7.27 (d, J=3.()5 Hz, 1 H), 7.30 (dd, J=8.48, 1.70 Hz, 1 H), 7.46 (d, J=8.14 Hz, 1 H). 7.73 (d, J=1.70 Hz. 1 H), 7.95 (dd. J=8.65. 2.54 Hz. 1 H). 8.37 (d, J=2.()3 Hz. 1 H) ppm; MS DCI/NH3): m/z 334 (M+H)^ Anal. Calculated for C2iH23N30-1.10 C4H404-1.00 H.O: C. 63.67; H, 6.18; N. 8.77. Found: C. 63.77; H, 6.26; N, 8.64.
Example 38 5-i6-|(cxo)-8-Mcthvl-8-aza-bicyclo[3.2.1|oct-3-vloxvl-pvridin-3-vli-2-trifluoromcthvl-
1 H-indole bi.sfumarate

The product of Example 37A (129 mg, 0.43 mmol) and 5-(4,4,5,5-tetramethyl-[l,3,21dioxaborolan-2-yl)-2-trifluoromethyl-lH-indole (Aldrich, 319 mg, 1.02 mmol) were treated according to the procedure outlined in Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 1.92 - 2.63 (m, 8 H). 2.85 (s, 3 H), 4.02 (s (br), 2 HI, 5.46 - 5.61 (m, 1 H), 6.71 (s, 4 H), 6.84 (d, J=8.48 Hz, 1 H), 6.95 (s, 1 H), 7.47 - 7.59 (m, 2 H), 7.85 (s, 1 H), 7.97 (dd, J=8.65, 2.54 Hz, 2 H), 8.40 (d, J=2.03 Hz, 1 H) ppm; MS DCI/NH3): m/z 402 (M+H)^ Anal. Calculated for C22H22F3N3O-2.0()C4H4O4: C, 56.87; H, 4.77; N, 6.63. Found: C, 56.98; H, 5.09; N. 6.29.
Example 39 4-{6-|(exo)-8-Methyl-8-aza'bicvclo[3.2.1|oct-3-yloxyl-pyridazin-3-yll-lH-indole
fumarate The product of Example 7D (129 mg, 0.51 mmol) was coupled with indole-4-boronic acid (Apollo, 161 mg, 1.0 mmol) to give the free base of the title compound (150 mg, 0.45 mmol). It was then was treated with fumaric acid (52.0 mg, 0.45 mmol) according to the procedure of Example of 5C to give the title compound as white solid. 'H NMR (300 MHz, CD3OD) 5 2.05 - 2.49 (m, 6 H) 2.60 - 2.71 (m, 2 H) 2.85 (s, 3 H) 4.01 - 4.07 (m, 2 H) 5.69 - 5.81 (m, 1 H) 6.69 (s, 2 H) 6.79 (dd, J=3.22, 0.85 Hz, 1 H) 7.23 - 7.29 (m, 2 H) 7.37 (d, J=3.05 Hz, 1 H) 7.41 (dd, J=7.29, 0.85 Hz, 1 H) 7.54 (d, J=8.14 Hz, 1 H) 8.08 (d, J=9.15 Hz, 1 H) ppm. MS (DCI/NH3): m/z 335 (M+H)^. Anal. Calculated for C2()H22N40-1.2C4O4H4: C 62.88; H, 5.70; N, 11.83. Found: C, 62.90; H, 5.53; N, 11.79.

Example 40 6-(5-l(exo)-8-Methvl-8-aza-bicvclol3.2.1loet-3-vloxvl-pvridin-2-vl)-lH-indole
hydrochloride
Example 40A 6- {5-1 (exo)-8-Methvl-8-aza-bicyclo[ 3.2.1 |oct-3-yloxv |-pvridin-2-yl 1 -1 H-indole Under N2, the mixture of the product Irom Example 11A (240 mg, 0.95 mmol) was coupled with 6-indolylboronic acid (Frontier Scientific. 229 mg, 1.42 mmol) according to the procedure of Example 1 IB to provide the title product. 'H NMR (300 MHz, CD3OD) 8 1.72 - 1.93 (m, 4 H), 2.00 - 2.25 (m, 4 H), 2.39 (s, 3 H), 3.23-3.35 (m, 2H), 4.56 - 4.82 (m, 1 H), 7.29 (d, J=3.05 Hz, 1 H), 7.46 (d, J=2.71 Hz, 1 H), 7.47 - 7.51 (m, 1 H), 7.53 (d, J=1.36 Hz, 1 H), 7.60 (d, J=8.52 Hz, 1 H), 7.76 (d, J=8.82 Hz, 1 H), 7.88 (s, 1 H), 8.22 (d, J=3.05 Hz, 1 H) ppm; MS (DCI/NH,) m/z 334 (M+Hf.
Example 40B 6- {5-f (cxo)-8-Methvl-8-aza-bicvclo| 3.2.1 |oct-3-vloxv l-pvridin-2-vl i -1 H-indole
hydrochloride The product of Example 40A (210 mg, 0.63 mmol) was treated with HCl (Aldrich, 4 M in dioxane, 0.5 mL, 2.0 mmol) EtOAc (10 mL) at ambient temperature for 10 hours and concentrated under reduced pressure to provide the title compound. H NMR (300 MHz, CD3OD) 8 2.14-2.32 (m, 2 H), 2.26 - 2.49 (m, 4 H), 2.49 - 2.65 (m, 2 H), 2.85 (s, 3 H), 3.99 - 4.18 (m, 2 H), 5.07 - 5.31 (m, 1 H), 6.60 (d, J=4.07 Hz, 1 H), 7.46 - 7.56 (m, 2 H), 7.82 (d, J=8.48 Hz, 1 H), 7.98 (s, 1 H), 8.34 (s, 1 H), 8.35 (d, J=2.71 Hz, 1 H), 8.55 (d, J=2.37 Hz, 1 H) ppm. MS (DCI/NH3): nVz 334 (M+H)^ Anal. Calculated for C2iH23N30-1.00 HCl-1.20 H2O: C, 64.42: H, 6.80; N, 10.73. Found: C, 64.54; H,6.61;N, 10.89.

Example 41 5-{5-|(endo)-8-Methvl-8-aza-bicyclo|3.2.1]oct-3-vloxvl-pvrazin-2-vl)-lH-indole tosylate
Example 41A 5-Bromo-pvrazin-2-ylamine To the solution of 2-aminopyrazine (Aldrich, 4.75 g. 50 mmol) in anhydrous MeCN (Aldrich, 50 mL) was slowly added the solution of N-bromosuccinimide (Aldrich, 8.90 g, 50 mmol) in MeCN (anhydrous, 50 mL) at 0-10°C. The reaction mixture was then stirred at ambient temperature and qunched with saturated Na^SiO,^ (5.0 mL). The mixture was concentrated and the residue was extracted with EtOAc (3 x 50 mL). The combined extracts were concentrated and the title compound was purified by chromatography (Si02, EtOAc/hexane = 1/1, v. R|=0.50). 'H NMR (300 MHz, CDCI3) 8 7.77 (d, J=1.36 Hz, 1 H), 8.09 (d, J=1.36 Hz, 1 H) ppm; nVz 174 (M+H)\ 174 (M+Hf.
Example 41B 5-Bromo-2-iodopvrazine Under N2, to the mixture of the product of Example 41A (7.50 g, 43 mmol) in DME (anhydrous, Aldrich, 200 mL) was added Csl (Aldrich, 11.20 g, 43 mmol), iodine (Aldrich, 5.52 g, 21.6 mmol), Cul (Stream, 2.52 g, 13.2 mmol) and isoamyl nitrite (34.8 niL, 259.2 mmol) at ambient temperature. It was then heated to 60°C and stirred for 30 min. till no gas evolution was observed. After being cooled down to room temperature, the dark mixtures was poured into a flask containing EtOAc (200 mL) and saturated NH4CI (200 mL), stirred for 10 min. The organic layer was scperated and the aqueous layer was extracted with EtOAc ( 2 x 1000 mL). The combined organic solution was washed with 5% of Na2S203 aqueous (2 x 50 niL), brine (50 mL) and dried over MgS04. The dring agents were filtered off and the organic solution was concentrated to provide the title compound. 'H NMR (300 MHz. CDCI3) 8 8.50 (d, J=1.36 Hz, 1 H), 8.62 (d. J=1.36 Hz, 1 H) ppm; m/z 284 (M+H)^ 286 (M+H)^

Example 41C (g/7Jr))-3-(5-Iodo-pyrazin-2-vloxv)-8-methvl-8-aza-bicvclo|3.2.noctane Under N2, the mixture of (endo)-tropinc (Aldrich, 1.54 g, 11 mmol) was treated with potassium t-butoxide (Aldrich, 0.96 g, 10 mmol) in THE (anhydrous, Aldrich, 50 mL) at ambient temperature for 1 h. The product of Example 41B (2.85 g, 10.0 mmol) and was added. The brown mixture was stirred at ambient icmpcrature for 4 hours and quenched with water (5 mL). The mixture was concentrated and the residue was purified by chromatography (150 g Si02, EtOAc : MeOH : NH3H2O, 90:10:1, R,. 0.20) to give the title compound. 'H NMR (300 MHz, CD3OD) 6 2.16 - 2.60 (m, 8 H). 2.84 (s. 3 H), 3.78 - 4.05 (m, 2 H), 5.17-5.40 (m, 1 H), 8.14 (d, .1=1.36 Hz, 1 H), 8.42 (d, J=1.36 Hz, 1 H) ppm; MS (DCI/NH3) m/z 346 (M-l-H)^
Example 4ID 5-{5-|(CT^6i)-8-Methvl-8-aza-bicyclo|3.2.11oct-3-yloxy|-pvrazin-2-vl|-lH-indole The product from Example 41C (200 mg, 0.58 mmol), was coupled with 5-indolylboronic acid (Rsycor, 143.3 mg, 0.89 mmol) according to the procedure of Example 9B to provide the title product. 'H NMR (300 MHz, CD^OD) 8 1.94 - 2.05 (m, 2 H), 2.07 - 2.29 (m, 6 H), 2.34 (s, 3 H), 3.15 - 3.27 (m, 2 H), 5.29 (t, J=5.09 Hz, 1 H), 6.53 (d, J=2.37 Hz, 1 H), 7.27 (d, J=3.39 Hz, 1 H), 7.47 (d, J=8.48 Hz, 1 H), 7.68 (dd, J=8.48, 1.70 Hz, 1 H),8.11 (s, 1 H), 8.17 (d, J=1.70 Hz, 1 H), 8.58 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH3) m/z 335 (M+H)^
Example 41E 5-{5-[(gn.^(y)-8-Methvl-8-aza-bicvclo[3.2.1loct-3-vloxvl-pvrazin-2-vn-lH-indole
tosylate The product of Example 4 ID (90 mg, 0.27 mmol) was treated with p-tokienesulfonic acid monohydrate TSOHH2O (Aldrich, 57 mg, 0.3 mmol) in EtOAc/EtOH (v. 4:1, 5 mL) at ambient temperature for 10 hour. The mixture was concentrated under reduced pressure to provide the title compound. H NMR (300 MHz, CD,,OD) 6 2.36 (s, 3 H), 2.38 - 2.48 (m, 4 H), 2.48 - 2.61 (m, 4 H), 2.84 (s, 3 H), 3.84 -4.05 (m, 2 H), 5.41 (t, J=4.41 Hz, 1 H), 7.23 (d, J=7.80 Hz, 2 H). 7.30 (s, 1 H), 7.49 (d, J=8.48Hz, 1 H), 7.65-7.77(m,4H), 8.13(d,J=1.70Hz, 1 H), 8.29 (s, 1 H) ppm. MS (DCI/NH3): m/z 335 (M+HY. Anal. Calculated for C2()H2:N40-1.38 C7HxSOy0.80 H.O:

C, 60.74; H, 5.95; N, 9.55. Found: C, 61.00; H, 5.63; N, 9.17.
Example 42 4-{5-[(f/it/o)-8-Methvl-8-aza-bicvclol3.2.rioct-3-vloxvl-pvrazin-2-vU-lH-indolc
bistosylatc
Example 42A 4-{5-|(g/7<7(j)-8-Methyl-8-aza-bicyclo|3.2.lloct-3-vloxv1-pyrazin-2-yl}-lH-indolc The product from Example 41C (200 mg. 0.58 mmol), was coupled with 4-indolylboronic acid (Apollo, 143.3 mg, 0.89 mmol) according to the procedure of Example 9B to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 1.97-2.06 (m, 2 H), 2.08 - 2.30 (m, 6 H), 2.34 (s, 3 H), 3.16 - 3.28 (m, 2 H), 5.33 (t, J=5.09 Hz, 1 H). 6.82 (d, J=3.39 Hz, 1 H), 7.22 (t, J=7.50 Hz, 1 H), 7.34 (d, J=3.()5 Hz, 1 H), 7.40 (d, J=7.46 Hz, 1 H), 7.47 (d, J=8.14 Hz, 1 H), 8.27 (d, J=1.36 Hz. 1 H), 8.61 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NHi) m/z 335 (M+H)^
Example 42B 4-(5-[(gnJo)-8-Methyl-8-aza-bicvcio|3.2.1|oct-3-yloxyl-pyrazin-2-yll-lH-indole
bi.stosylate The product of Example 42A (40 mg, 0.12 mmol) was treated with p-toluenesulfonic acid monohydrate TsOH-H^O (Aldrich, 27 mg, 0.15 mmol) in EtOAc/EtOH (v. 4:1, 5 mL) at ambient temperature for 10 hours. The mixture was concentrated under reduced pressure to provide the title compound. H NMR (300 MHz, CD3OD) 5 2.36 (s, 6 H) 2.40-2.48 (m. 4 H), 2.50 - 2.64 (m. 2 H), 2.85 (s, 3 H), 3.87 -4.04 (m. 2 H), 5.26 - 5.63 (m. 1 H), 7.19 - 7.29 (m, 6 H), 7.35 (s, 1 H), 7.42 (d. J=6.44 Hz. 1 H), 7.49(d.J=8.14Hz. 1 H),7.71 (d, J=8.48 Hz. 4 H), 8.38 (d, J=1.36 Hz, 1 H), 8.68 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH.O: m/z 335 (M+Hf. Anal. Calculated for C2„H22N4O-2.00 C7HxSO,v0.50 H.O: C, 59.37; H, 5.71; N. 8.15. Found: C, 59.56; H, 6.10; N, 8.17.
Example 43 6- {5-1 (g/?^r;)-8-Methvl-8-aza-bicvclo| 3.2.1 |oct-3-v]oxvl-pvrazin-2-vl 1-1 H-indoIe

tosylate
Example 43A 6-i5-|(ew/(;)-8-Methvl-8-aza-bicyclo[3.2.11oct-3-yloxy]-pyrazin-2-yll-lH-indole The product from Example 4IC (200 mg, 0.58 mmol), was coupled with 6-indolylboronic acid (Frontier Scientific, 143.3 mg, 0.89 mmol) according to the procedure of Example 9B to provide the title product. 'H NMR (300 MHz, CD3OD) 5 1.93 - 2.05 (m, 2 H), 2.08 - 2.28 (m, 6 H), 2.33 (s, 3 H), 3.13 - 3.26 (m, 2 H), 5.29 (t, J=4.92 Hz, 1 H), 6.47 (d, J=3.05 Hz, 1 H), 7.30 (d, J=3.39 Hz. 1 H), 7.54 - 7.68 (m, 2 H), 7.96 (s, 1 H), 8.19 (d, J=1.36 Hz, 1 H), 8.60 (d, J=1.36 Hz. 1 H) ppm. MS (DCI/NH3) m/z 335 (M+Hf.
Example 43B 6-(5-[(g/?J(9)-8-Methvl-8-aza-bicvclo|3.2.1 |oct-3-vloxy|-pvrazin-2-vll-lH-indole
tosylate The product of Example 43A (80 mg, 0.24 mmol) was treated with p-loluenesulfonic acid monohydratc TSOHH2O (Aldrich, 57 mg, 0.30 mmol) in EtOAc/EtOH (v. 4:1, 5 mL) at ambient temperature for 10 hours. The mixture was concentrated under reduced pressure to provide the title compound. H NMR (300 MHz, CD3OD) 6 2.36 (s, 3 H), 2.37 - 2.48 (m, 6 H), 2.47 - 2.63 (m, 2 H), 2.84 (s, 3 H), 3.83 -4.02 (m. 2 H), 5.27 - 5.50 (m, 1 H), 6.48 (d, J=2.37 Hz, 1 H), 7.32 (t, J=1.70 Hz, 1 H), 7.53-7.67(m, 2H), 7.71 (d, J=8.14 Hz, 2 H), 7.99 (s, 1 H), 8.29 (d, J=1.36 Hz, 1 H), 8.64 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH3): m/z 335 (M+H)^ Anal. Calculated for C20H22N4OI.I5C7H8SO.VO.75H2O: C, 61.71; H, 6.04; N, 10.26. Found: C, 61.74; H, 5.72; N, 9.87.

Example 44 l6-(lH-Indol-6-vl)-pvridin-3-vll-|(em/o)-8-methvl-8-aza-bicvclo[3.2.1|oct-3-vll-amine
trifluoroacetatc The product of Example 20A (139 mg, 0.55 mmol) was coupled with indole-6-boronic acid (Frontier Scientific. 165 mg, 1.02 mmol) according to the procedure of Example 8 to provide the title compound. 'H NMR (300 MHz, CD3OD) 8 2.18 - 2.63 (m, 8 H) 2.84 (s, 3 H) 3.82 (I, J=6.10 Hz, 1 H) 3.96 (s, 2 H) 6.57 (dd, J=3.05, 0.68 Hz, 1 H) 7.41 - 7.47 (m, 2 H) 7.74 - 7.93 (m, 4 H) 8.10 (d, J=9.16 Hz, 1 H) ppm. MS (DCI/NH3): m/z 333 (M+H)^ Anal. Calculated for C2iH24N4'2.45 CF3CO2H: C, 50.85; H. 4.36; N, 9.16. Found: C. 50.72; H, 4.43; N, 9.25.
Example 45 5- {6-1 (g/7 Jo)-9-methyl-9-azabicvclo| 3.3.11nonan-3-yloxv1pvridazin-3-vl I -1 H-indole
trifluoroacetatc
Example 45A (CT^/o)-9-Methvl-9-azabicvclo|3.3.1 |nonan-3-ol (f';Wf;)-9-methyl-9-azabicyclo[3.3.1 |nonan-3-ol was prepared according to the procedure as described in WO 03062235. 'H NMR (300 MHz, CD3OD) 8 1.22 - 1.32 (m, 2H), 1.35- 1.47 (m, 3 H), 1.98 (tt, J=13.60, 5.21 Hz, 2 H). 2.30 - 2.56 (m, 6 H), 2.87-2.96 (m, 2 H), 4.04 - 4.15 (m, 1 H) ppm. MS (DCI/NH3): m/z 156 (M+Hf.
Example 45B (c^nJo)-3-(6-chloropvridazin-3-yloxv)-9-methvl-9-azabicvclo|3.3.1|nonane The product of Example 45A ( 467 mg, 3.0 mmol) was coupled with 3,6-dichloropyridazine ( 614 mg, 3.3 mmol) according to the procedure of Example 1 A. H NMR (300 MHz, CD3OD) 8 1.59 (ddd, J=14.41, 6.27, 6.10 Hz, 1 H), 1.77 (dd, J=14.92, 5.76 Hz, 2 H), 2.06 - 2.28 (m, 4 H), 2.52 - 2.82 (m, 3 H). 2.90 (s, 3 H), 3.51 (t, J=5.76 Hz, 2H), 5.55(tt, J=6.91, 1.74 Hz, 1 H), 7.26 (d, J=:9.16 Hz, 1 H), 7.69 (d, J=9.16 Hz, 1 H) ppm. MS (DCI/NH3): m/z 268 (M+H)^
Example 45C

5-|6-|(f^nc/r;)-9-methyl-9-azabicvclo|3.3.1|nonan-3-yloxvlpvridazin-3-vU-lH-indole
trifluoroacetate The product of example 45B (145 mg, 0.54 mmol) was coupled with indole-5-boronic acid (Ryscor, 165 mg, 1.02 mmol) according to the procedure of Example IB to provide the title compound. 'H NMR (300 MHz, CD^OD) 8 1.57 - 1.81 (m, 2 H) 1.95 -2.47 (m, 5 H) 2.67 - 2.92 (m. 3 H) 2.98 - 3.06 (m, 3 H) 3.65 0- J=5.09 Hz, 2 H) 5.61 (t, J=6.95 Hz, 1 H) 6.59 (d, J=3.05 Hz, 1 H) 7.34 (d, J=3.05 Hz, 1 H) 7.37 - 7.43 (m, 1 H) 7.55 (d, J=8.48 Hz, 1 H) 7.74 (dd, J=8.65, 1.86 Hz, 1 H) 8.18 (d, J=1.70 Hz, 1 H) 8.20 -8.27 (m, 1 H) ppm. MS (DCI/NH3): m/z 349 (M+H)\ Anal. Calculated for C2iH24N4O-2.10CF3CO2H: C, 51.48; H, 4.47; N, 9.53. Found: C, 51.31; H, 4.33; N, 9.36.
Example 46 (endo)-3-[6-(Benzo|blthiophcn-5-yl)pyridazin-3-yloxyl-9-mcthyl-9-azabicvcloi3.3.1 Inonane trifluoroacetate The product of Example 45B (145 mg, 0.54 mmol) was coupled with the product of lOA (280 mg, 1.02 mmol) according to the procedure of Example IB to provide the title compound. 'H NMR (300 MHz. CD3OD) 8 1.56 - 1.81 (m, 2 H), 1.94 - 2.48 (m, 5 H), 2.68 - 2.92 (m, 3 H), 2.98 - 3.08 (m, 3 H), 3.65 (t, J=5.09 Hz, 2 H), 5.66 (t, J=6.95 Hz, 1 H), 7.34 (d, J=9.16 Hz, 1 H), 7.50 (d, J=5.76 Hz, 1 H), 7.68 (d, J=5.76 Hz, 1 H), 7.96 - 8.02 (m, 1 H), 8.04 - 8.10 (m, 1 H), 8.20 (d, J=9.49 Hz, 1 H), 8.45 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH3): m/z 366 (M+H)^ Anal. Calculated for C2iH23N30S-1.13 CF3CO2H: C, 56.51; H, 4.92; N, 8.50. Found: C. 56.56; H. 4.75; N, 8.44.
Example 47 5-{5-|(endo)-8-Mcthvl-8-a/a-bicvclo[3.2.1]oct-3-vloxvl-Pvrazin-2-vU-lH-pviTolo|2,3-
bl pyridine bistosylatc
Example 47A 5-(4.4.5,5-Tctramcthvl-ri,3.2ldioxaborolan-2-yl)-lH-pvrrolo[2.3-blpyridine 5-Bromo-lH-pyrrolo|2,3-blpyridine (Chemgenx, 0.90 g, 4.57 mmol) was coupled with bis(pinacolalo)diboron (Aldrich, 1.27 g, 5.0 mmol) according to the procedure of Example lOA. 'H NMR (300 MHz, CDCI3) 8 1.37 (s, 12 H) 6.52 (d, J=3.73 Hz, 1 H).

7.38{d,J=3.73Hz, 1 H), 8.34 (d, J=1.36 Hz, 1 H). 8.49 (d. J=1.70 Hz, 1 H) ppm; m/z
245 (M+H)^
Example 47B 5-|5-|(endo)-8-Mcthvl-8-aza-bicvclo|3.2.1loct-3-vloxvl-pvrazin-2-vU-lH-pviTolor2,3-
blpvridine tosylatc The product from Example 41C (207 mg, 0.60 mmol), was coupled with the product of Example 47A (200.0 mg, 0.82 mmol) according to the procedure of Example lOB. 'H NMR (300 MHz, CD3OD) 8 1.98 - 2.09 (m, 2 H), 2.10 - 2.32 (m, 6 H), 2.40 (s, 3 H), 5.32 (t, J=5.09 Hz, 1 H), 6.58 (d, J=3.39 Hz, 1 H), 7.44 (d, J=3.73 Hz, 1 H), 8.25 (d, J=1.36 Hz, 1 H), 8.53 (d, J=2.03 Hz, 1 H), 8.65 (d, J=1.36 Hz, 1 H), 8.78 (d, J=2.03 Hz, 1 H) ppm. MS (DCI/NH3) m/z 336 (M+H)^
Example 47C 5-i5-|(endo)-8-Methyl-8-aza-bicyclo|3.2.1|oct-3-yloxyl-pyrazin-2-yU-lH-pynolo[2,3-
blpvridine bistosylate The product of Example 47B (90 mg, 0.27 mmol) was treated with p-toluenesulfonic acid monohydrate TSOHH2O (Aldrich, 95 mg, 0.5 mmol) in EtOAc/EtOH (v. 4:1, 10 mL) at ambient temperature for 10 hours. The mixture was concentrated under reduced pressure to provide the title compound. H NMR (300 MHz, CD^OD) 6 2.35 (s, 6H), 2.38 - 2.45 (m, 2 H). 2.45 - 2.61 (m, 6 H), 2.85 (s, 3 H), 3.85 -4.07 (m, 2 H), 5.46 (t, J=4.75 Hz, 1 H), 6.97 (d. J=3.39 Hz. 1 H), 7.22 (d, J=7.80 Hz, 4 H) 7.70(d,J=8.14Hz,4H), 7.76(d,J=3.73Hz, 1 H), 8.42 (d, J= 1.36 Hz, 1 H), 8.85 (d, J-1.36 Hz, 1 H), 9.04 (d, J=1.70 Hz, 1 H), 9.27 (d, J=1.70 Hz, 1 H) ppm. MS (DCI/NH3): m/z 336 (M+H)^ Anal. Calculated for C,9H2|N50-2.17 CyHsSO.r 1.00 H.O: C, 56.48; H, 5.59; N, 9.63. Found: C, 56.48; H, 5.37; N, 9.67.

Example 48 5-(5-l(e.w)-8-Methvl-8-aza-bicvclol3.2.1loct-3-vloxvl-pvridin-2-vII-lH-pvrrolof2,3-
bjpyridine bistosylatc
Example 48A
5-{5-l(exo)-8-Methvl-8-aza-bicvclof3.2.11oct-3-vloxvl-pvridin-2-vl}-lH-pviTolol2.3-
blpyridinc The product from Example 1 lA (152 mg, 0.60 mmol), was coupled with the product of Example 47A (200.0 mg, 0.82 mmol) according to the procedure of Example 9B. 'HNMR(300MHZ.CD3OD) 8 1.76- 1.92 (m, 4 H), 2.06 - 2.20 (m, 4 H), 2.36 (s, 3 H). 3.18-3.31 (m, 2 H), 4.64-4.79 (m, 1 H), 6.57 (d, J=3.39 Hz, 1 H), 7.43 (d,J=3.73 Hz, 1 H), 7.81 (d, J=8.82 Hz. 1 H), 8.29 (d, J=3.05 Hz, 1 H), 8.45 (d, J=2.03 Hz, 1 H), 8.72 (d. J=2.03 Hz, 1 H) ppm. MS (DCI/NHO m/z 335 (M+H)^
Example 48B 5-15-[(exo)-8-Methvl-8-aza-bicyclo| 3.2.1 |oct-3-vloxvl-pvridin-2-vll-lH-pyrrolo(2,3-
blpvridine bistosylate The product of Example 48A (100 mg, 0.30 mmol) was treated with p-lolucnesulfonic acid monohydrate TsOH-H20 (Aldrich, 95 mg, 0.5 mmol) in EtOAc/EtOH (v. 4:1, 10 mL) at ambient temperature for 10 hours. The mixture was concentrated under reduced pressure to provide the title compound. H NMR (300 MHz, CD,OD) 8 2.18 - 2.47 (m, 2 H), 2.15-2.40 (m, lOH), 2.46 - 2.60 (m, 2 H), 2.85 (s, 3 H), 3.99 - 4.06 (m, 2 H), 4.95 - 5.19 (m, 1 H), 6.83 (d, J=3.39 Hz, 1 H), 7.22 (d, J=8.14 Hz, 4 H), 7.66 (d, J=3.39 Hz, 1 H), 7.70 (d, J=8.48 Hz, 4 H), 8.09 (d, J=8.82 Hz, 1 H), 8.48 (d, J=2.71 Hz, 1 H), 8.87 (d, J=2.03 Hz, 1 H), 8.91 (d, J=2.03 Hz. 1 H) ppm. MS (DCI/NH3): nVz 335 iM+H)\ Anal. Calculated for C2oH22N40-2.14 C7H8SOr0.50 H.O: C, 59.01; H, 5.68; N, 7.87. Found: C, 58.88; H, 5.63; N, 7.47.

Example 49 5-(5-l(exo)-8-Methvl-8-aza-bicvclol3.2.1loct-3-vloxvl-pvridin-3-vU-lH-indole
tri( hydrochloride)
Example 49A (t:'A-o)-3-(5-Chloro-pyridin-3-yloxy)-8-mcthyl-8-aza-bicyclo[3.2.1]octane {endoyTropinc (Aldrich, 0.56 g, 4.0 mmol), was coupled with 3-chloro-5-hydroxy-pyridine (Aldrich, 0.26 g, 2.0 mmol), in the presence of DIAD (di-isopropyl azadicarboxylate, Aldrich, 0.81 g, 4.0 mmol) and Ph.^P (Aldrich, 1.14 g, 4.0 mmol) in THE (anhydrous, Aldrich, 20 mL) at ambient temperature for two days. The reaction mixture was concentrated. The title product was purified by chromatography (SiO?, CH2CI2: MeOH : NHvHaO, 90:10:1, Rj. 0.45). 'H NMR ( 300 MHz , CD3OD) 6 1.66 -1.91 (m, 4 H), 1.98 - 2.19 (m, 4 H), 2.33 (s, 3 H), 3.22 - 3.28 (m. 2 H), 4.58 - 4.79 (m, 1 H), 7.49 (dd,J=2.37, 1.70 Hz, IH), 8.11 (d,J=1.70Hz, 1 H), 8.15 (d, J=2.37 Hz, 1 H) ppm. MS (DCI/NH3) m/z 255 (M+H)^ 253 (M+H)^
Example 49B 5-{5-[(gA(;)-8-Methyl-8-aza-bicyclo|3.2.1|oct-3-vloxyl-pvridin-3-yU-lH-indole Under N2, the mixture of the product from Example 49A (250 mg, 1.00 mmol) was coupled with 5-Indolylboronic acid (Rsycor, 240.0 mg, 1.50 mmol) according to the procedure of Example 9B. 'H NMR (300 MHz, CD3OD) 8 1.71 - 1.92 (m, 4 H), 2.02 -2.21 (m, 4 H), 2.34 (s, 3 H), 3.23 - 3.30 (m, 2 H), 4.63 - 4.80 (m, 1 H), 6.54 (d, J=3.05 Hz, 1 H), 7.29 (d, J=3.39 Hz, 1 H), 7.38 (dd, J=8.48, 2.03 Hz. 1 H), 7.47 - 7.53 (m, 1 H), 7.58 - 7.64 (m, 1 H), 7.83 (d, J=1.36 Hz, 1 H), 8.15 (d, J=2.71 Hz, 1 H), 8.39 (d, J=1.70 Hz. 1 H) ppm. MS (DCI/NH3) m/z 334 (M+H)^
Example 49C 5-{5-|(exo)-8-Methyl-8-aza-bicyclo|3.2.l1oct-3-vloxvl-pvridin-3-vll-lH-indole
tri(hydrochloride) The product of Example 49B (90 mg, 0.27 mmol) was treated with HCl (Aldrich, 4 M in dioxane, 0.25 mL, 1.0 mmol) in 'PrOAc/'PrOH (v. 4:1, 5 niL) at ambient

temperature for 2 hoours to provide the title compound, 'H NMR (300 MHz. CD3OD) 5 2.01 - 2.66 (m, 8 H), 2.83 (s. 3 H), 3.92 - 4.09 (m. 2 H), 4.98 - 5.15 (m, 1 H), 6.61 (d, J=3.05 Hz, 1 H), 7.33 - 7.40 (m, 1 H), 7.50 - 7.63 (m, 2 H). 8.04 - 8.10 (m, 2 H), 8.44 (d, J=1.70 Hz, 1 H), 8.80 (s, 1 H) ppm. MS (DCI/NH3): nVz 334 (M+Hf. Anal. Calculated for C2iH23N3O-3.00HCl-4.60 H2O: C, 47.98; H, 6.14: N. 7.85. Found: C, 47.62; H, 6.38; N, 7.62.
Example 50 5-{5-[(gAX')-8-Methyl-8-aza-bicyclo[3.2.11oct-3-yloxy|-pyrazin-2-vlMH-indoletosylate
Example 50A (gA-o)-3-(5-Iodo-pyrazin-2-yloxv)-8-methYl-8-aza-bicvclo| 3.2.1 loctane Under N2, the mixture of product from 7C (0.42 g. 3.0 mmol) was treated with potassium t-butoxide (Aldrich, 0.32 g, 3.3 mmol) in THF (anhydrous, Aldrich, 50 mL) at ambient temperature for 1 hours. The product of Example 41B (1.00 g, 3.5 mmol) and was added. The mixture was stirred at ambient temperature for 4 hours and quenched with water (5 mL). The mixture was concentrated and the residue was purified by chromatography (150 g Si02, EtOAc : MeOH : NH3H2O, 90:10; 1, Rr. 0.40) to provide the title compound. 'H NMR (300 MHz, CD3OD) 6 1.90 - 2.25 (m, 4 H), 2.31 - 2.60 (m, 4 H), 2.84 (s, 3 H), 3.94 - 4.11 (m, 2 H), 5.32 - 5.57 (m, 1 H), 8.06 (d, J=1.36 Hz, 1 H), 8.42 (d, J=1.36 Hz, 1 H) ppm; MS (DCI/NH3) m/z 346 (M+H)^
Example 508 5-{5-l(exo)-8-MethYl-8-aza-bicyclo|3.2.1|oct-3-vloxvl-pvrazin-2-vl|-lH-indole The product from Example 50A (200 mg, 0.58 mmol). was coupled with 5-indolylboronic acid (Rsycor, 143.3 mg, 0.89 mmol) according to the procedure of Example 9B. 'H NMR (300 MHz, CD3OD) 5 1.95 - 2.17 (m, 2 H), 2.16 - 2.31 (m, 2 H), 2.36 - 2.47 (m, 2 H), 2.48 - 2.67 (m, 2 H), 2.85 (s, 3 H), 3.90 - 4.17 (m, 1 H). 5.36 - 5.69 (m, 1 H), 6.53 (d, J=3.39 Hz, 1 H), 7.29 (d, J=3.05 Hz, 1 H), 7.48 (d, J=8.48 Hz, 1 H) 7.69 (dd, J=8.48, 1.70 Hz, 1 H), 8.13(s, 1 H) 8.20 (d, J= 1.36 Hz, 1 H), 8.62 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH3) m/z 335 (M+H)^.

Example 50C 5-{5-|(cxo)-8-Methyl-8-aza-bicyclo|3.2.1|oct-3-yloxy|-pvrazin-2-yl]-iH-indole tosylate
The product of Example SOB (170 mg, 0.50 mmol) was treated with p-toluenesulfonic acid monohydrate TsOH-H20 (Aldrich, 100 mg, 0.51 mmol) in EtOAc/EtOH (v. 4:1, 5 mL) at ambient temperature for 10 hours. The mixture was concentrated under reduced pressure to provide the title compound. 'H NMR (300 MHz, CD3OD) 6 2.01 - 2.15 (m, 2 H), 2.16 - 2.30 (m, 2 H), 2.36 (s, 3 H), 2.39 - 2.49 (m, 2 H), 2.52 - 2.67 (m, 2 H), 2.84 (s, 3 H), 3.96 - 4.13 (m, 2 H), 5.43 - 5.70 (m, 1 H), 7.23 (d, J=8.14 Hz, 2 H), 7.30 (s, 1 H), 7.49 (d, J=8.48 Hz, 1 H), 7.62 - 7.75 (m, 4 H), 8.12 (s, 1 H), 8.22 (d, J=1.36 Hz, 1 H), 8.68 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NHO: nVz 335 (M+H)^
Example 51 4-|5-|(exo)-8-Methvl-8-aza-bicyclo|3.2.1 |oct-3-vloxvl-pvrazin-2-vl}-lH-indole tosylate
Example 51A 4-(5-r(exo)-8-Methyl-8-aza-bicvclol3.2.1 |oct-3-yloxvl-pvrazin-2-yl|-lH-indole The product from Example 50A (200 mg, 0.58 mmol), was coupled with 4-indolylboronic acid (Apollo, 143.3 mg, 0.89 mmol) according to the procedure of Example 98. 'H NMR (300 MHz, CD3OD) 8 2.02 - 2.28 (m, 4 H), 2.34 - 2.48 (m, 2 H), 2.50 - 2.65 (m, 2 H), 2.86 (s, 3 H), 3.96 - 4.07 (m. 2 H), 5.45 - 5.68 (m, 1 H), 6.82 (d, J=4.07 Hz, 1 H), 7.23 (t, J=7.60 Hz 1 H), 7.35 (d, J=3.39 Hz, 1 H), 7.41 (d, J=6.44 Hz, 1 H), 7.48(d, J=8.14Hz, 1 H), 8.29 (d, J=1.36 Hz, 1 H), 8.65 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NHv) nVz 335 (M+H)^
Example 51B 4-{5-|(exo)-8-Methvl-8-aza-bicvclo|3.2.l|oct-3-vloxvl-pvrazin-2-vl|-lH-indole tosylate
The product of Example 51A (120 mg, 0.36 mmol) was treated with p-toluenesulfonic acid monohydrate TSOHH2O (Aldrich, 68 mg, 0.36 mmol) in EtOAc/EtOH (v. 4:1, 5 mL) at ambient temperature for 10 hours. The mixture was concentrated under reduced pressure to provide the title compound. H NMR (300 MHz, CDiOD) 8 2.02 - 2.17 (m, 2 H), 2.18 - 2.32 (m, 2 H), 2.36 (s, 3 H), 2.38 - 2.50 (m, 2 H),

2.52 - 2.69 (ra, 2 H), 2.85 (s. 3 H), 4.00 - 4.11 (m, 2 H), 7.17 - 7.28 (m, 1 H), 7.35 (s, 1 H), 7.42(d,J=7.12Hz, 1 H), 7.49 (d, J=8.14 Hz. 1 H), 7.70 (d, J=8.14 Hz, 1 H), 8.30 (d, .1=1.70 Hz, 1 H), 8.67 (d, J=1.36 Hz, 1 H) ppin. MS (DCI/NH,): m/z 335 (M+Hf.
Example 52 6-i5-|(cxo)-8-Mcthyl-8-aza-bicyclo|3.2.1loct-3-vloxvl-pyrazin-2-yl 1-lH-indole tosylate
Example 52A 6-(5-[(exo)-8-Methvl-8-aza-bicyclol3.2.11oct-3-yloxy1-pyrazin-2-yl|-lH-indolc The product from Example 41C (200 mg, 0.58 mmol). was coupled with 6-indolylboronic acid (Frontier Scientific, 143.3 mg, 0.89 mmol) according to the procedure of Example 9B. 'H NMR (300 MHz, CD3OD) 8 1.97 - 2.16 (m, 2 H), 2.14 -2.26(m, 2H), 2.31 - 2.65 (m, 4 H), 2.81 (s, 3 H), 3.84 - 4.05 (m. 2 H), 5.33 - 5.71 (m, 1 H), 6.47 (d, J=3.05 Hz, 1 H), 7.31 (d, J=3.05 Hz, 1 H), 7.48 - 7.73 (m, 2 H), 7.99 (s, 1 H), 8.20 (d, J=1.36 Hz, 1 H), 8.63 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH3) m/z 335 (M+Hf.
Example 52B 6-{5-|(exo)-8-Methvl-8-aza-bicvclo|3.2. l|oct-3-vloxvl-pvrazin-2-vl1-lH-indole tosylate
The product of Example 52A (90 mg. 0.27 mmol) was treated with p-loluenesulfonic acid monohydrate TsOH-H20 (Aldrich, 57 mg, 0.30 mmol) in EtOAc/EtOH (v. 4:1, 5 mL) at ambient temperature for 10 hours. The mixture was concentrated under reduced pressure to provide the title compound. H NMR (300 MHz, CD3OD) 5 2.01 - 2.14 (m, 2 H), 2.16 - 2.31 (m. 2 H), 2.36 (s, 3 H), 2.39 - 2.51 (m, 2 H), 2.50 - 2.65 (m, 2 H), 2.84 (s. 3 H), 3.98 - 4.08 (m, 2 H). 5,41 - 5.68 (m. 1 H), 6.48 (d, J=2.37 Hz, 1 H), 7.23 (d, J=7.80 Hz, 2 H), 7.32 (s, 1 H), 7.55 - 7.67 (m, 2 H), 7.71 (d, J=8.48 Hz, 2 H), 7.99 (s, 1 H), 8.22 (d, J=1.36 Hz, 1 H), 8.65 (d, J=1.36 Hz, 1 H) ppm. MS (DCI/NH3): m/z 335 (M+H)^
Example 53 ((:^»J6')-A^-(5-(lH-hidol-5-vl)pvridin-3-vl)-8-methvl-8-azabicvclo[3.2.1]octan-3-amine
Example 53A

(enJ6>)-N-(5-Bromopyridin-3-vl)-8-methvl-8-azabicyclo|3.2.1loctan-3-amine 8-Mcthyl-8-azabicyclo[3.2.11octan-3-onc (Aldrich. 695 mg, 5.0 mmol) reacted with bromopyridin-3-amine (950 mg, 5.5 mmol) according to the procedure of Example 2()A to give the title compound (650 mg, yield. 44%). 'H NMR (300 MHz, CD3OD) 5 1.54 - 2.25 (m, 8 H), 2.29 (s, 3 H), 3.16 |s (broad), 2 H), 3.50 (I, J=6.61 Hz. 1 H), 7.08 (t, 7=2.20 Hz, 1 H), 7.79 (d, 7=1.70 Hz, 1 H). 7.85 (d, 7=2.37 Hz, 1 H) ppm; MS (DCI/NHO: m/z 298 (M+H)', 296 (M+H)^
Example 53B (t^«^/o)-A^-(5-(lH-Indol-5-y])pyridin-3-vl)-8-methvl-8-azabicvclo[3.2.1 loctan-3-amine/;-
tosylatc The product of Example 53 A (150 mg, 0.5 mmol) was coupled with indole-5-boronic acid (Frontier, 150 mg, 0.93 mmol) according to the procedure of Example 93 to provide the free base of the title compound (82 mg, yield, 50%), which was treated with p-toluenesulfonic acid hydrate (Aldrich, 47 mg. 0.25 mmol) in EtOAc/EtOH (v. 10:1, 5 mL) at room temperature for 16 hours. The precipitate was collected and dried to give the title compound (99.3 mg. yield, 67.2%>). 'H NMR (300 MHz, CD3OD) 8 2.15- 2.30 (m, 2 H). 2.30 - 2.42 (m, 5.5 H), 2.42 - 2.63 (m, 4 H). 2.82 (s, 3 H), 3.81 (t, .7=5.9 Hz, 1 H), 3.93 Is (broad), 2 H), 6.54 (d, 7=2.4 Hz, 1 H), 7.21 (d, 7=8.1 Hz, 3 H), 7.32 (d, ,7=3.1 Hz, 1 H), 7.39 (dd, 7=8.4, 1.7 Hz, 1 H), 7.47 - 7.59 (m, 2 H), 7.70 (d, 7=8.5 Hz, 3 H), 7.86 (d, ,7=1.7 Hz, 1 H), 7.90 (d, 7=2.4 Hz, 1 H), 8.23 (d. .7=1.7 Hz, 1 H) ppm. MS DCl/NHV): in/z 333 (M+H)^ Anal. Calculated for C2iH24N4-1.50C7H8O3S-1.20H2O: C, 61.78; H, 6.32; N, 9.15. Found: C, 61.78; H, 6.19; N. 8.99.

Example 54 {eiulo)-N-{5-{ 1 H-lndol-4-yl )pyridin-3-vl)-8-methvl-8-azabicvclo[3.2.1 |octan-3-amine p-
tosylate Example 54A (mt/o)-/>/-(5-(lH-Indol-4-yl)pyridin-3-yl)-8-methvl-8-azabicyclo|3.2.l1octan-3-amine The product of Example 53A (150 mg, 0.5 mmol) was coupled with indole-4-boronic acid (Frontier, 150 mg, 0.93 mmol) according to the procedure of Example 9B to provide the title compound (80 mg, yield, 48%), 'H NMR (300 MHz, CD3OD) 8 1.78 -1.96 (m, 2 H), 2.05 - 2.16 (m, 4 H), 2.17 - 2.30 (m, 2 H), 2.33 (s, 3 H), 3.21 |s (broad), 2 HI, 3.63 (t, 7=6.8 Hz,IH), 6.57 (d, 7=3.4 Hz, 1 H), 7.08 (d, 7=7.1 Hz, 1 H), 7.15-7.26 (m, 2 H), 7.31 (d, 7=3.1 Hz, 1 H), 7.42 (d, 7=7.8 Hz, 1 H). 7.89 (d, 7=2.7 Hz, 1 H), 8.05 (d, 7=1.7 Hz, 1 H) ppm; MS DCI/NH3): m/z 333 (M+H)^
Example 54B (t'myo)-A^-(5-(lH-Indol-4-yl)pyridin-3-vl)-8-methyl-8-azabicyclo[3.2.1|octan-3-aminep-
tosylate The product of Example 54A (80 mg, 0.24 mmol) was treated with p-tolucnesulfonic acid hydrate (Aldrich, 47 mg, 0.25 mmol) in EtOAc/EtOH (v. 10:1, 5 mL) at room temperature for 16 hours. The precipitate was collected and dried to give the title compound (85.3 mg, yield, 58.5%). 'H NMR (300 MHz, CD3OD) 8 2.17 - 2.31 (m, 2 H), 2.31 -2.41 (m, 5.8 H), 2.41 - 2.60 (m, 4 H), 2.82 (s, 3 H), 3.79 (t, 7=5.9 Hz, 1 H), 3.93 Is (broad), 2 H), 7.16 (dd, J=7.5, 1.0 Hz, 1 H), 7.21-7.27 (m, 5.2 H), 7.37 (d, 7=3.1 Hz, 1 H), 7.50 (d, .7=8.1 Hz, 1.0 H), 7.62 - 7.66 (m, 1.0 H). 7.70 (d, 7=8.1 Hz, 3.2 H), 7.99 (d, 7=2.4 Hz, 1 H), 8.24 (d, 7=1.4 Hz, 1 H) ppm. MS DCI/NH3): m/z 333 (M+H)^ Anal. Calculated for C2iH24N4-1.60C7HxO3S1.20H2O: C. 61.43; H, 6.28; N, 8.90. Found: C, 61.72; H, 6.26; N, 8.64.

Example 55 (e/7c/(;)-A^-(5-(lH-Indol-6-yl)pyridin-3-yl)-8-methvl-8-azabicvclo[3.2.1|octan-3-aminep-
tosylate Example 55A (mc/r;)-A^-(5-(lH-hidol-6-yl)pvridin-3-yl)-8-methyl-8-azabicyclo(3.2.11octan-3-amine The product of Example 53A (150 mg, 0.5 mmol) was coupled with indolc-6-boronic acid (Frontier, 150 mg, 0.93 mmol) according to the procedure of Example 9B to provide the free base of the title compound (102 mg, yield, 60%). 'H NMR (300 MHz, CD3OD) 5 1.80 - 1.98 (m, 2 H), 2.06 - 2.19 (m, 4 H), 2.19-2.32 (m, 2 H), 2.35 (s, 3 H), 3.24 Is (broad), 2 H), 3.64 (t, 7=6.8 Hz,l H), 6.47 (d, 7=3.4 Hz, 1 H), 7.16 - 7.21 (m, 1 H), 7.22 - 7.34 (m, 2 H), 7.57 - 7.67 (m, 2 H), 7.83 (d, 7=2.7 Hz, 1 H), 8.06 (d, 7=2.0 Hz, 1 H) ppm; MS DCI/NH3): m/z 333 (M+H)^
Example 55B (t^/i(io)-A^-(5-(lH-Indol-6-yl)pvridin-3-yl)-8-methyl-8-azabicvclo[3.2.11octan-3-amine p-
tosylate The product of Example 55A (102 mg, 0.3 mmol) was treated with p-toluenesulfonic acid hydrate (Aldrich, 57 mg, 0.30 mmol) in EtOAc/EtOH (v. 10:1, 5 mL) at room temperature for 16 hours. The precipitate was collected and dried to give the title compound (137.2mg, yield, 59.4%). 'H NMR (300 MHz, CD3OD) 2.16 - 2.64 (m, 12.2 H), 2.82 (s, 3 H), 3.78 (t, 7=6.3 Hz. 1 H), 3.92 |s (broad). 2 H), 6.48 (d, 7=4.1 Hz, 1 H), 7.22 (d, 7=7.8 Hz, 2.8 H), 7.27 (dd, 7=8.1, 1.7 Hz, 1 H), 7.30 (d, 7=3.1 Hz, 1 H), 7.31 - 7.34 (m, 1 H), 7.61 - 7.66 (m, 2 H). 7.70 (d, 7=8.1 Hz, 2.8 H), 7.88 (d, 7=2.4 Hz, 1 H), 8.17 (d, 7=1.7 Hz, 1 H) ppm. MS DCI/NH3): m/z 333 (M+H)'. Anal. Calculated for C2|H24N4-1.40C7HHO3S-0.70H2O: C, 63.11; H, 6.29; N, 9.56. Found: C, 63.17; H, 6.61; N, 9.43.
Example 56 (c/?d^o)TA^-(5-l2-(trifluoromethvl)-lH-indol-5-vl|pvridin-3-vll-8-Methvl-8-
azabicvclo[3.2.1 |octan-3-amine fumarate The product of Example 9A (110 mg, 0.4 mmol) was coupled with the product of Example 7A (300 mg, 0.97 mmol) according to the procedure described in Example 93

to provide the free base of the title compound (38 mg, yield, 22.5%), which was (38 mg.0.09 mmol) was then treated with fumaric acid (12 mg, 0.1 mmol) in EtOAc/EtOH (v. 10:1, 5 mL ) at room temperature for 16 hours. The precipitate was filtered and dried to give the title compound (50.4 mg, yield, 99%). 'H NMR (300 MHz, CD3OD) 6 2.28 -2.37 (m, 4H), 2.42- 2.57 (m, 4 H), 2.84 (s, 3 H), 3.02 Is(broad), 2 H|, 4.80-4.90 (m, 1 H) 6.72 (s, 2.6 H), 6.97 (s, 1 H), 7.47 - 7.57 (m, 2 H), 7.85 (d, 7=8.8 Hz, 2 H). 8.17 (s, 1 H) 8.30 (s, 1 H) ppm. MS DCI/NH3): m/z402 (M+H)^ Anal. Calculated for C22H22F3N4O-1.30C4O4H4: C, 59.15; H. 4.96; N, 7.61. Found: C, 59.29; H. 5.07; N, 7.37.
Example 57 5-i5-[(gnc/r;)-8-Methyl-8-azabicvclo| 3.2.1 |octan-3-yloxy|pyridin-2-vll-lH-pvrrolo|2,3-
blpyridine tosylate
Example 57A 5-{ 5-1 (gnt/o)-8-Methvl-8-aza-bicvclo| 3.2.1 |oct-3-yloxyl-pyridin-2-Yll-lH-pvrrolo|2,3-
bjpyridine The product of Example 9A (200 mg, 0.80 mmol), was coupled with the product of Example 47A (244.0 mg, 1.0 mmol) according to the procedure of Example 9B. to provide the title compound (190 mg, yield. 1\%). 'H NMR (300 MHz, CD3OD) 8 1.93 -2.27 (m, 8 H), 2.33 (s, 3 H). 3.20 [s (broad.), 2 H], 4.69 (t. 7=5.1 Hz. 1 H), 6.57 (d, 7=3.4 Hz, 1 H), 7.39 - 7.48 (m, 2 H), 7.83 (d, 7=8.5 Hz. 1 H), 8.25 (d, 7=2.7 Hz, 1 H), 8.46 (d, ./=2.0 Hz. 1 H), 8.73 (d, 7=2.4 Hz, 1 H) ppm. MS (DCl/NH,) m/z 335 (M-i-H)^
Example 57 B 5-|5-|(tw/o)-8-Methvl-8-aza-bicvclol3.2.1|oct-3-vloxvl-pyridin-2-vll-lH-pvrrolo|2,3-
b [pyridine tosylate The product of Example 48A (80 mg, 0.24 mmol) was treated with p-toluenesulfonic acid monohydrate TSOHH2O (Aldrich, 57 mg, 0.3 mmol) in EtOAc/EtOH (v. 4:1, 10 mL) at ambient temperature for 10 hours. The precipitated solid was filtered and dried to provide the title compound (100 nig, yield, 79.6%). H NMR (300 MHz, CD3OD) 8 2.27 - 2.69 (m. 11 H), 2.84 (s, 3 H), 3.84 - 4.08 (m, 2 H), 4.84 -

4.94 (m, 1 H), 6.62 (d, 7=3.4 Hz, I H), 7.23 (d, 7=8.1 Hz, 2 H), 7.47 (d, 7=3.7 Hz, 1 H), 7.56 (dd, 7=8.8, 3.1 Hz, 1 H), 7.71 (d, 7=8.1 Hz, 2 H), 7.92 (d, 7=8.8 Hz, 1 H), 8.36 (d, ,7=2.7 Hz, 1 H), 8.56 (d, 7=2.0 Hz, 1 H), 8.77 (d, 7=2.0 Hz. 1 H) ppm. MS (DCyNHV): m/z 335 {M+Uf. Anal. Calculated for C20H22N4OI.IO C7H8SO.vO.8O H2O: C, 61.81; H. 6.07; N, 10.41. Found: C, 62.15; H, 5.92; N, 10.05.
Example 58 5-{5-[(g/u/o)-8-Methyl-8-azabicvclol3.2.1|octan-3-yloxvlpvridin-2-yllindohn-2-one
bis(hydrochloric acid)
Example 58A 5-(4,4,5,5-Tetramethvl-1.3,2-dioxaborolan-2-yl)indolin-2-one Under N2, 5-Bromoindolin-2-one (Aldrich, 2.11 g, 10.0 mmol) was coupled with bis(pinacolato)dibon (Frontier Scientific, 3.05 g, 12 mmol) in the pre.sence of KOAc (Aldrich, 1.50 g, 15.0 mmol) under the catalysis of PdCl2(dppt>CH2Cl2 (Aldrich, 163 mg, 0.2 mmol) in anhydrous dioxane (Aldrich, 50 mL) at 85 °C for 15 hours. After the reaction was completed, it was cooled down to ambient temperature and diluted with EtOAc (100 mL). The mixture was then washed with brine (2x10 mL) and concentrated. The residue was purified with chromatography on silica gel (EtOAc/hexanes, v. 1 : 1, Ri=0.5) to provide the title compound (2.43 g. yield, 93.8%). 'H NMR (300 MHz, CD^0D)5 1.24 (s, 12H), 3.51(s, 2H), 6.88(d,./=8.5Hz. 1 H), 7.52 - 7.75 (m, 2 H) ppm. MS (DCI/NH3): m/z 260 (M+H)^
Example 58B 5-{5-[((?»^/(j)-8-Methyl-8-azabicvclo[3.2.1|octan-3-Yloxv]pyridin-2-vllindolin-2-one The product of Example 9A (200 mg, 0.80 mmol). was coupled with the product of Example 58A (260 mg, 1.0 mmol) according to the procedure of Example 9B. to provide the title compound (130 mg, yield, 46.4%). 'H NMR (300 MHz, CD.^OD) 5 1.93 - 2.04 (m, 2 H), 2.06 - 2.15 (m. 7=2.4 Hz. 4 H), 2.14 - 2.25 (m, 2 H), 2.33 (s, 3 H), 3.20 [s (broad). 2 H). 4.67 (t. 7=5.1 Hz, 1 H), 6.96 (d, 7=8.1 Hz, 1 H). 7.38 (dd, 7=8.8, 3.1 Hz, 1 H). 7.69 - 7.80 (m. 3 H). 8.18 (d, 7=3.1 Hz, 1 H) ppm. MS (DCI/NH.O nVz 350 (M+H)^

Example 58C 5-15-[(em76')-8-Methvl-8-azabicyclo[3.2.1 |octan-3-yloxvlpyridin-2-yl lindolin-2-one
bis(hydrochloric acid) The product of Example 48A (80 mg, 0.24 mmol) was treated with p-toluenesulfonic acid monohydrale TSOHH2O (Aldrich. 57 mg, 0.3 mmol) in EtOAc/EtOH (v. 4:1, 10 mL) at ambient temperature for 10 hours. The precipitated solid was filtered and dried to provide the title compound (100 mg, yield, 79.6%). 'H NMR (300 MHz, CD3OD) 8 2.31 - 2.67 (m, 8 H), 2.85 (s, 3 H), 3.68 (s, 2 H), 3.90 - 4.08 (m, 2 H), 5.03 (t, 7=4.6 Hz, 1 H), 7.14 (d, 7=9.2 Hz, 1 H). 7.73 - 7.82 (m, 2 H), 8.22 - 8.34 (m, 2 H), 8.53 (d, 7=2.4 Hz, 1 H)ppm. MS (DCI/NH,) m/z 350 (M+H)\ Anal. Calculated for C2iH23N3O2-2.00 HCl-3.0 H.O: C, 52.95: H, 6.56; N, 8.82. Found: C, 52.67; H, 6.47; N, 8.62.
Example 59 5-{ 5-|(<^/K/o)-8-Azabicvclol3.2.1 loctan-3-vloxvlpvridin-2-vl 1-lH-indole
bis(hvdrochloric acid) Example 59A (fnc/»)-3-(6-Chloropvridin-3-vloxv)-8-azabicvclo[3.2.1 joctanc To a solution of the product of Example 9A (253 mg, 1.0 mmol) in anhydrous 1,2-dichloroethane (Aldrich, 10 mL) was added 1-chloroethyl carbonochloridate (Aldrich, 286 mg, 2.0 mmol). The mixture was healed to rcilux for 15 hours. It was then concentrated, the residue was diluted with 5 niL of methanol. The soltuion was stirred at 65 °C for 1 h. and then concentrated. The residue was purified with chromatography on silica gel (CH2Cl2:MeOH:NH3-H20, v. 90:10:2, Rr=0.1) to give the title compound (180 mg, yield, 75%). 'H NMR (300 MHz, CD3OD) 5 2.03 - 2.62 (m, 8 H), 4.01 - 4.14 (m, 2 H), 4.75-4.82 (m, 1 H), 7.37 - 7.42 (m. 1 H). 7.44 (d, 7=3.1 Hz, 1 H), 8.03 - 8.13 (m, 1 H) ppm. MS (DCI/NH3) m/z 241 (M+H)^ 239 (M+H)^
Example 59B 5-i5-|(^^nJo)-8-Azabicvclo[3.2.11octan-3-vloxylpvridin-2-vl}-lH-indole The product of Example 59A (180 mg, 0.75 mmol), was coupled with IH-indol-5-ylboronic acid (160 mg, 1.0 mmol) according to the procedure of Example 9B. to

provide the title compound (120 mg, yield, 50.1 %). 'H NMR (300 MHz, CD3OD) 5 1.77 - 1.94 (m, 2 H), 1.96 - 2.07 (m, 2 H), 2.07 - 2.30 (m, 4 H), 3.46 - 3.59 (m, 2 H), 4.73 (t, .7=4.9 Hz, 1 H), 6.51 (d, 7=4.1 Hz, 1 H), 7.26 (d, 7=3.1 Hz, 1 H), 7.39 (dd, 7=8.8, 3.1 Hz, 1 H), 7.45 (d, 7=8.5 Hz, 1 H), 7.62 (dd, 7=8.5, 1.7 Hz, 1 H), 7.77 (d, 7=8.8 Hz, 1 H). 8.03 (d. 7=1.7 Hz, I H), 8.17 (d, 7=2.7 Hz, 1 H) ppm. MS (DCI/NHO m/z 320 (M+Hf.
Example 59C 5-{5-|(ew/o)-8-Azabicvclol3.2.1|octan-3-yloxy|pvridin-2-vn-lH-indole
bis(hydrochloric acid) The product of Example 59B (120 mg, 0.38 mmol) was treated with HCl (4 M, in dioxane, 0.2 mL, 0.8 mmol) in EtOAc (5.0 mL) at ambient temperature for 10 hours. The precipitated solid was filtered and dried to provide the title compound (130 mg, yield, 79.6%). 'H NMR (300 MHz, CD3OD) 8 2.09 - 2.26 (m, 2 H). 2.28 - 2.43 (m, 2 H), 2.40 -2.59 (m, 4 H), 4.02 - 4.23 (m, 2 H), 5.02 (t, 7=4.4 Hz, 1 H), 6.65 (d, 7=3.1 Hz, 1 H), 7.42 (d, 7=3.4 Hz, 1 H), 7.57-7.71 (m, 2 H), 8.15 (s, 1 H), 8.19 (dd, 7=9.1, 2.7 Hz, 1 H), 8.29 (d, 7=9.1 Hz,l H), 8.44 (d, 7=2.7 Hz, 1 H) ppm. MS (DCI/NH3) m/z 320 (M+H)^. Anal. Calculated for C2oH2iN30-2.00HCh 1.18 H.O: C, 58.08; H, 6.18; N, 10.16. Found: C, 57.73; H, 6.37; N, 9.95.
Example 60 (//^,J/-.55.^.s)-3-(6-(lH-hidol-5-vl)pvridin-3-vloxv)-8-methvl-8-azabicvclo|3.2.rioctane
8-oxide 3-Chlorobcnzoperoxoic acid (Aldrich, 70-75%, 240 mg, 1.0 mmol) was added to a solution of product of example 9B (333 mg, 1.0 mmol) in MeOH (10 mL). It was then slined at ambient temperature for 4 hours. The solution was directly purified by preparative HPLC [GiLson, column, Xtcrra® 5 |.im, 40 x 100 mm. Eluting Solvent, MeCN / H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide) (v. 10/90 to 75/25 over 20 minutes. Flow rate of 40 mlVminute, uv detector set to 250 nm|. The fractions with lower rention time were collected and concentrated under reduced pressure to provide the title compound (130 mg, yield, 37.2%). H NMR (300 MHz, CD3OD) 8 2.19 - 2.42 (m, 4 H), 2.45 - 2.74 (m, 4 H), 3.34 (s, 3 H), 3.57 - 3.70 (m, 2 H). 4.72 (t, 7=5.3 Hz, 1 H), 6.52 (d, 7=2.4 Hz, 1 H), 7.27 (d, 7=3.1 Hz, 1 H), 7.40 - 7.52

(m, 2 H), 7.64 (dd, /=8.5, 1.7 Hz, 1 H), 7.80 (d, .7=8.8 Hz, I H), 8.05 (d, 7=2.0 Hz, 1 H), 8.23 (d, 7=3.1 Hz. 1 H) ppm; MS (DCI/NH3) m/z 350 (M+H)^
Example 61 (7/e,Jr,55'.gr)-3-(6-(lH-Indol-5-vl)pvridin-3-vloxv)-8-methvl-8-azabicvclo|3.2.11octane
8-oxide 3-Chlorobenzoperoxoic acid (Aldrich, 70-75%, 240 mg, 1.0 mmol) was added to a solution of product of example 9B (333 mg. 1.0 mmol) in MeOH (10 mL). It was then stirred at ambient temperature for 4 hours. The solution was directly purified by preparative HPLC [Gilson. column, Xterra® 5 |.im, 40 x 100 mm. Eluting Solvent, MeCN / H2O (0.1 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide) (v. 10/90 to 75/25 over 20 minutes. Flow rate of 40 mL/minute, uv detector set to 250 nm]. The fractions with higher rention lime were collected and concentrated under reduced pressure to provide the title compound (110 mg, yield, 31.5%). 'H NMR (300 MHz, CD3OD) 6 1.96 - 2.07 (m, 2 H), 2.19 - 2.37 (m, 2 H), 2.44 - 2.59 (m, 2 H), 3.06 (dt, 7=15.3,4.2Hz, 2H), 3.24(s, 3H), 3.47-3.59(m, 2H),4.71 -4.81 (m, 1 H), 6.52 (d, 7=3.1 Hz, 1 H), 7.27 (d, .7=3.4 Hz, 1 H), 7.42 - 7.50 (m, 2 H), 7.64 (dd, 7=8.5, 1.7 Hz, 1 H). 7.80 (d, 7=8.8 Hz, 1 H), 8.05 (d, 7=1.7 Hz, 1 H), 8.24 (d, 7=3.1 Hz, 1 H) ppm; MS (DCI/NH3) m/z 350 (M+H)^
Example 62 4-{5-|(t^nJo)-8-Azabicyclo|3.2.1|octan-3-yloxylpyridin-2-yl|-lH-indole trinuoroacetate
The product of Example 59A (120 mg, 0.50 mmol), was coupled with IH-indol-4-ylboronic acid (Frontier, 121 mg. 0.75 mmol) according to the procedure of Example 9B. The crude mixture was purified with preparative HPLC (Gilson, column, Xterra® 5 |.un. 40 X 100 mm. Eluting Solvent. MeCN / H2O containing 0.1% v. TFA (90% to 10% over 25 minutes. Flow rate of 40 mL/minute, uv detector set to 254 imi). The fractions containing the desired product were collected and concentrated under reduced pressure and the residue was stiired in ether/ethanol (v. 10/1, 5 mL) at ambient temperature for 16 hours to provide the title compound. (80 mg, yield, 29.2%). 'H NMR (300 MHz, CD3OD) 6 2.06 - 2.24 (m, 2 H), 2.25 - 2.60 (m, 6 H) ,4.00 - 4.33 (m, 2 H), 4.90 - 5.02 (m, 1 H), 6.72 (dd, 7=3.39, 1.02 Hz, 1 H), 7.25 - 7.32 (m. 1 H), 7.34 - 7.39 (m, 1 H), 7.43

(d, 7=3.05 Hz, 1 H), 7.58 (dt, 7=7.80, 1.02 Hz, 1 H), 7.93 (dd, ,/=8.99, 2.88 Hz, 1 H), 8.11 (d, 7=8.82 Hz, 1 H), 8.46 (d, 7=2.71 Hz. 1 H) ppm. MS (DCI/NHO m/z 320 (M+Hf .Anal. Calc. for C2()H2iN3O-2.00CF3CO2H-0.50H:O: C, 51.80; H, 4.35; N, 7.55. Found: C, 51.84; H. 4.28; N. 7.30.
Example 63 5-{5-[(gAY;)-8-Azabicyclor3.2.11octan-3-yloxy|pyridin-2-yl}-lH-indo]c bis(hydrochloric
acid) Example 63A (g.vo)-3-(6-Chloropvridin-3-vloxv)-8-azabicvclo| 3.2.1 loctane To a solution of the product of Example 1 lA (2.52 g, 9.97 mmol) in 1,2-dichloroethane (25 ml) (anhydrous) was added 1-chloroethyl carbonochloridate (5.54 ml, 49.9 mmol) The mixture was then healed to 100°C for 50h. h was then cooled down to ambient temperature, 25 mL of MeOH was added. The mixtue was then heated to reflux for 1 hour. It is concentrated and the crude was purified with chromatography on silica gel (CH2Cl2:MeOH:NHvH20, v. 90:10:2, R,=0.15) to give the title compound (180 mg, yield, 75%). 'H NMR (300 MHz, CD3OD) 8 1.56 - 1.71 (m, 2 H), 1.74 - 1.94 (m, 4 H), 2.01 - 2.26 (m, 2 H), 3.46 - 3.73 (m, 2 H). 4.58 - 4.76 (m, 1 H), 7.32 (d, 7=8.1 Hz. 1 H), 7.43 (dd, 7=8.8, 3.0 Hz, 1 H), 8.01 (d, 7=2.7 Hz, 1 H) ppm. MS (DCI/NH3) m/z 241 (M+H)^ 239 (M+H)^
Example 63B 5- {5-1 (eA-o)-8-Azabicvclol 3.2.1 loctan-3-vloxvlpvridin-2-yl 1 -1 H-indole The procduct of Example 63 A (0.24 g, 1.0 mmol) was coupled with lH-indol-5-ylboronic acid (Frontier, 0.241 g, 1.50 mmol) acceding to the procedure of Example 9B to provide the title compound (0.25 g, yield, 79 % ). 'H NMR (300 MHz, CD3OD) 8 1.69- 1.83 (m, 2 H), 1.86- 1.99 (m, 4 H), 2.18 - 2.32 (m. 2 H), 3.67 - 3.87 (m, 2 H), 4.69 - 4.82 (m, 1 H), 6.52 (d, 7=2.37 Hz, 1 H), 7.27 (d, 7=3.05 Hz, 1 H), 7.45 (dl, 7=8.48, 0.85 Hz, 1 H), 7.49 (dd, 7=8.82, 3.05 Hz, 2 H), 7.62 (dd, .7=8.48, 1.70 Hz, 2 H), 7.76 (d, 7=8.14 Hz, 2 H), 8.03 (d, 7=1.36 Hz, 2 H), 8.22 (d, 7=2.37 Hz, 1 H) ppm; MS (DCI/NH3) m/z 320 (M+H)^
Example 63C

5-f 5-[(gAV9)-8-AzabicvcIo|3.2.11octan-3-yloxy|pyridin-2-v] 1-1 H-indole bi.s(hydrochloric
acid) The product of Example 63B (0.25 g, 0.79 mmol) was treated with HCl (Aldrich, 4 M in dioxane, 0.5 mL, 2.0 mmol) in EtOAc/EtOH (v. 10/1, 10 mL). The precipitated solid was filtered and dried to give the title compound (0.20 g. yield, 64.9%). 'H NMR (300 MHz, CD:,OD) 81.94 - 2.13 (m, 2 H), 2.12 - 2.35 (m, 4 H), 2.42 - 2.68 (m, 2 H), 4.09 - 4.37 (m, 2 H), 5.05 - 5.28 (m, 1 H), 6.67 (d, 7=3.39 Hz, 1 H), 7.43 (d, 7=3.05 Hz, 1 H), 7.57 - 7.72 (m, 2 H), 8.16 (s, 1 H), 8.27 - 8.39 (m, 2 H), 8.52 (d, 7=2.37 Hz, 1 H) ppm; MS (DCI/NH3) m/z 320 (M+H)^Ana]. Calc. for C2oH2iN30-2.00HCI-0.90H20; C, 58.80; H, 6.12; N, 10.29. Found: C, 58.50; H, 5.86; N, 10.08
Example 64 5-f5-|(gn<7(;)-8-Azabicvclo(3.2.1 |octan-3-vloxvlpvridin-2-vllindolin-2-one
The product of Example 59A (119 mg, 0.50 mmol), was coupled with the product of Example 58A (194 mg, 0.75 mmol) according to the procedure of Example 9B. to provide the title compound (150 mg, yield, 89.0%). 'H NMR (300 MHz, DMSO-D(,) 5 ] .86 - 2.42 (m, 8 H), 3.54 (s. 2 H), 3.89 - 4.06 (m, 2 H), 4.83 (t, 7=4.07 Hz, 1 H), 6.88 (d, 7=7.80 Hz, 1 H), 7.47 (dd, 7=8.82, 3.05 Hz, 1 H), 7.78 - 7.94 (m, 3 H), 8.32 (d. 7=2.71 Hz, 1 H), 10.50 (s, 1 H) ppm; MS (DCI/NH3) m/z 336 (M+H)^
Example 65 5-{5-[(c^nJo)-8-Azabicyclo[3.2.1|octan-3-yloxylpvridin-2-vli-lH-pyiTolol2.3-blpyridine The product of Example 59A (200 mg, 0.80 mmol), was coupled with the product of Example 47A (183 mg, 0.75 mmol) according to the procedure of Example 9B. to provide the title compound (80 mg, yield, 49.9%.). 'H NMR (300 MHz. DMSO-D,) 5 1.89 - 2.16 (m, 4 H), 2.17 - 2.40 (m, 4 H), 3.78 - 4.26 (m. 2 H), 4.86 (t, 7=4.24 Hz, 1 H), 6.51 (dd, 7=3.39, 1.70 Hz, 1 H), 7.46 - 7.58 (m, 2 H), 7.97 (d, 7=8.82 Hz, 1 H), 8.39 (d, 7=2.71 Hz, 1 H), 8.52 (d, 7=2.03 Hz, 1 H), 8.88 (d, 7=2.03 Hz, 1 H), 11.70 (s, 1 H) ppm; MS (DCI/NH3) m/z 321 (M+H)^.
Example 66

5-{5-|(eAY))-8-Azabicvclof3.2.1|octan-3-vloxvlpvridin-2-vll-lH-pvrrolo|2.3-b1pvridine The product of Example 63A (200 mg, 0.80 mmol) was coupled with the product of Example 47A (183 mg, 0.75 mmol) according to the procedure of Example 9B. to provide the title compomid (120 mg, yield, 74.9%). 'H NMR (300 MHz, DMSO-Dft) 8 1.82-2.18(m,6H), 2.18-2.40 (m, 2 H), 3.91 - 4.30 (m. 2 H), 4.71 - 5.30 (m, 1 H),6.51 (dd, 7=3.39, 1.70 Hz, 1 H), 7.47 - 7.55 (m, 1 H), 7.61 (dd. 7=8.82, 3.05 Hz, 1 H), 7.94 (d, 7=8.82 Hz, 1 H), 8.42 (d, 7=2.71 Hz, 1 H), 8.52 (d, 7=2.03 Hz, 1 H), 8.88 (d, 7=2.03 Hz, 1 H), 11.71 (s, 1 H)ppm;MS(DCyNH,,)nVz321 (M+H)^
Compositions of the Invention
The invention also provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of formula (I) in combination with a pharmaceutically acceptable carrier. The compositions comprise compounds of the invention formulated together with one or more non-toxic pharmaceutically acceptable carriers. The pharmaceutical compositions can be formulated for oral administration in solid or liquid form, for parenteral injection or for rectal administration.
The term "pharmaceutically acceptable carrier," as used herein, means a non¬toxic, inert solid, semi-solid or liquid filler, diluent, encapsulating material or formulation auxiliary of any type. Some examples of materials which can serve as pharmaceutically acceptable carriers are sugars such as lactose, glucose and sucrose; starches such as corn starch and potato starch; cellulose and its derivatives such as sodium carboxymcthyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; cocoa butter and suppository waxes; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols; such a propylene glycol; esters such as ethyl oleate and ethyl laurate; agar; buffering agents such as magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen-free water; isotonic saline; Ringer's solution; ethyl alcohol, and phosphate buffer solutions, as well as other non¬toxic compatible lubricants such as sodium lauryl sulfate and magnesium stearate, as well as coloring agents, releasing agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the composition, according to the judgment of one skilled in the art of formulations.
The pharmaceutical compositions of this invention can be administered to humans

and other mammals orally, rectally, parenterally, intracisternally, intravaginally, intraperitoneally, topically (as by powders, ointments or drops), bucally or as an oral or nasal spray. The term "parenterally," as used herein, refers to modes of administration, including intravenous, intramuscular, intraperitoneal, intrasternal, subcutaneous, intraarticular injection and infusion.
Pharmaceutical compositions for parenteral injection comprise pharmaceutically acceptable sterile aqueous or nonaqueous solutions, dispersions, suspensions or emulsions and sterile powders for reconstitution into sterile injectable solutions or dispersions. Examples of suitable aqueous and nonaqueous cairiers, diluents, solvents or vehicles include water, ethanol, polyols (propylene glycol, polyethylene glycol, glycerol, and the like, and suitable mixtures thereof), vegetable oils (such as olive oil) and injectable organic esters such as ethyl oleate, or suitable mixtures thereof. Suitable Huidity of the composition may be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersions, and by the use of surfactants.
These compositions can also contain adjuvants such as preservative agents, wetting agents, emulsifying agents, and dispersing agents. Prevention of the action of microorganisms can be ensured by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, and the like. It also can be desirable to include isotonic agents, for example, sugars, sodium chloride and the like. Prolonged absorption of the injectable pharmaceutical form can be brought about by the use of agents delaying absorption, for example, aluminum monostearatc and gelatin.
In some cases, in order to prolong the effect of a drug, it is often desirable to slow the absorption of the drug from subcutaneous or intramuscular injection. This can be accomplished by the use of a liquid suspension of crystalline or amorphous material with poor water solubility. The rate of absorption of the drug can depend upon its rate of dissolution, which, in turn, may depend upon crystal size and crystalline form. Alternatively, dissolving or suspending the drug in an oil vehicle can administer a parenterally administered drug form.
Suspensions, in addition to the active compounds, can contain suspending agents, for example, ethoxylated isostearyl alcohols, polyoxyethylcnc sorbitol and sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar-agar.

tragacanth, and mixtures thereof.
If desired, and for more effective distribution, the compounds of the invention can be incorporated into slow-release or targeted-delivery systems such as polymer matrices, liposomes, and microspheres. They may be sterilized, for example, by filtration through a bacteria-retaining filter or by incorporation of sterilizing agents in the form of sterile solid compositions, which may be dissolved in sterile water or some other sterile injectable medium immediately before use.
Injectable depot forms are made by forming microencapsulated matrices of the drug in biodegradable polymers such as polylactide-polyglycolide. Depending upon the ratio of drug to polymer and the nature of the particular polymer employed, the rate of drug release can be controlled. Examples of other biodegradable polymers include poly(orthoesters) and poly(anhydrides) Depot injectable formulations also are prepared by entrapping the drug in liposomes or microemulsions which are compatible with body tissues.
The injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter or by incorporating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable medium just prior to use.
Injectable preparations, for example, sterile injectable aqueous or oleaginous suspensions can be formulated according to the known art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation also can be a sterile injectable solution, suspension or emulsion in a nontoxic, parenterally acceptable diluent or solvent .such as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that can be employed are water. Ringer's solution, U.S.P. and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil can be employed including synthetic mono- or diglyceridcs. In addition, fatty acids such as oleic acid are used in the preparation of injectables.
Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules. In such solid dosage forms, one or more compounds of the invention is mixed with at least one inert pharmaceutic ally acceptable carrier such as sodium citrate or dicalcium phosphate and/or a) fillers or extenders such as starches.

lactose, sucrose, glucose, mannitol, and salicylic acid; b) binders such as carboxymclhylcellulose, alginates, gelatin, polyvinylpynolidinonc, sucrose, and acacia; c) humectants such as glycerol; d) disintegrating agents such as agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates, and sodium carbonate; c) solution retarding agents such as paraffin; f) absorption accelerators such as quaternary ammonium compounds; g) wetting agents such as cetyl alcohol and glycerol monostearale; h) absorbents such as kaolin and bentonite clay; and i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, and mixtures thereof. In the case of capsules, tablets and pills, the dosage form may also comprise buffering agents.
Solid compositions of a similar type may also be employed as fillers in soft and hard-filled gelatin capsules using lactose or milk sugar as well as high molecular weight polyethylene glycols.
The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings and other coatings well-known in the pharmaceutical formulating art. They can optionally contain opacifying agents and can also be of a composition that they release the active ingredient{s) only, or preferentially, in a certain part of the intestinal tract in a delayed manner. Examples of materials useful for delaying release of the active agent can include polymeric substances and waxes.
Compositions for rectal or vaginal administration are preferably suppositories which can be prepared by mixing the compounds of this invention with suitable non-irritating carriers such as cocoa butter, polyethylene glycol or a suppository wax which are solid at ambient temperature but liquid at body temperature and therefore melt in the rectum or vaginal cavity and release the active compound.
Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, microemulsions, solutions, suspensions, syrups and elixirs, hi addition to the active compounds, the liquid dosage forms may contain inert diluents commonly used in the art such as, for example, water or other solvents, solubiiizing agents and emulsifiers such as ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl bcnzoate, propylene glycol, 1,3-butylenc glycol, dimethylformamide. oils (in particular, cottonseed, groundnut, corn, germ, olive, castor, and sesame oils), glycerol.

tetrahydrofurfuryl alcohol, polyethylene glycols and fatty acid esters of sorbitan, and mixtures thereof.
Besides inert diluents, the oral compositions can also include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents.
Dosage forms for topical or transdermal administration of a compound of this invention include ointments, pastes, creams, lotions, gels, powders, solutions, sprays, inhalants or patches. A desired compound of the invention is admixed under sterile conditions with a pharmaceutically acceptable canicr and any needed preservatives or buffers as may be required. Ophthalmic formulation, eardrops, eye ointments, powders and solutions are also contemplated as being within the scope of this invention.
The ointments, pastes, creams and gels may contain, in addition to an active compound of this invention, animal and vegetable fats, oils, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide, or mixtures thereof.
Powders and sprays can contain, in addition to the compounds of this invention, lactose, talc, silicic acid, aluminum hydroxide, calcium silicates and polyamide powder, or mixtures of these substances. Sprays can additionally contain customary propellants such as chlorofluorohydrocarbons.
Compounds of the invention also can be administered in the form of liposomes. As is known in the art, liposomes are generally derived from phospholipids or other lipid substances. Liposomes are formed by mono- or multi-lamellar hydraled liquid crystals that are dispersed in an aqueous medium. Any non-toxic, physiologically acceptable and metabolizable lipid capable of forming liposomes may be used. The present compositions in liposome form may contain, in addition to the compounds of the invention, stabilizers, preservatives, and the like. The preferred lipids are the natural and synthetic phospholipids and phosphatidylcholines (lecithins) used separately or together.
Methods to form liposomes are known in the art. See, for example, Prcscolt, Ed., Methods in Cell Biology, Volume XIV, Academic Press, New York, N. Y., (1976), p 33 et seq.
Dosage forms for topical administration of a compound of this invention include powders, sprays, ointments and inhalants. The active compound is mixed under sterile

conditions with a pharmaceutically acceptable carrier and any needed preservatives, buffers or propellants. Ophthalmic formulations, eye ointments, powders and solutions are also contemplated as being within the scope of this invention. Aqueous liquid compositions of the invention also are particularly useful.
The compounds of the invention can be used in the form of pharmaceutically acceptable salts, esters, or amides derived from inorganic or organic acids. The term "pharmaceutically acceptable saUs, esters and amides," as used herein, include salts, zwitterions, esters and amides of compounds of formula (1) which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, and the like, are commensurate with a reasonable benefit/risk ratio, and are effective for their intended use.
The term "pharmaceutically acceptable salt" refers to those salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, and the like, and are commensurate with a reasonable benefit/risk ratio. Pharmaceutically acceptable salts are well-known in the art. The salts can be piepared in situ during the final isolation and purification of the compounds of the invention or separately by reacting a free base function with a suitable organic acid.
Representative acid addition salts include, but are not limited to acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, fumarate. glycerophosphate, hemisulfate, heptanoatc, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxyethansulfonate (isethionate), lactate, maleate, methanesulfonate. nicotinate, 2-naphthalencsulfonate, oxalate, pamoate, pectinate, persulfate, 3-phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, phosphate, glutamate, bicarbonate, p-toluenesulfonate and undecanoate.
Also, the basic nitrogen-containing groups can be quaternized with such agents as lower alkyl halides such as methyl, ethyl, propyl, and butyl chlorides, bromides and iodides; dialkyl sulfates such as dimethyl, diethyl, dibutyl and diamyl sulfates; long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides; arylalkyl halides such as benzyl and phenethyl bromides and others. Water or oil-soluble

or dispersible products are thereby obtained.
Examples of acids which can be employed to form pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, hydrobromic acid, sulphuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, succinic acid, and citric acid.
Basic addition salts can be prepared in situ during the final isolation and purification of compounds of this invention by reacting a carboxylic acid-containing moiety with a suitable base such as the hydroxide, carbonate or bicarbonate of a pharmaceutically acceptable metal cation or with ammonia or an organic primary, secondary or tertiary amine. Pharmaceutically acceptable salts include, but are not limited to, cations based on alkali metals or alkaline earth metals such as lithium, sodium, potassium, calcium, magnesium, and aluminum salts, and the like, and nontoxic quaternary ammonia and amine cations including ammonium, letramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylaminc, diethylamine, ethylamine and the such as. Other representative organic amines useful for the formation of base addition salts include ethylenediamine, ethanolamine, diethanolamine, piperidine, and piperazine.
The term "pharmaceutically acceptable ester," as used herein, refers to esters of compounds of the invention which hydrolyze in vivo and include those that break down readily in the human body to leave the parent compound or a salt thereof. Examples of pharmaceutically acceptable, non-toxic esters of the invention include C|-to-C6 alkyl esters and C5-I0-C7 cycloalkyl esters, although Ci-to-C4 alkyl esters arc preferred. Esters of the compounds of formula (I) can be prepared according to conventional methods. Pharmaceutically acceptable esters can be appended onto hydroxy groups by reaction of the compound that contains the hydroxy group with acid and an aikylcarboxylic acid such as acetic acid, or with acid and an aryicarboxylic acid such as benzoic acid, hi the case of compounds containing carboxylic acid groups, the pharmaceutically acceptable esters are prepared from compounds containing the carboxylic acid groups by reaction of the compound with base such as triethylaminc and an alkyl halide, alkyl trifilate. for example with methyl iodide, benzyl iodide, cyclopentyl iodide. They also can be prepared by reaction of the compound with an acid such as hydrochloric acid and an aikylcarboxylic acid such as acetic acid, or with acid and an aryicarboxylic acid such as benzoic acid.

The term "pharmaceutically acceptable amide," as used herein, refers to non-toxic amides of the invention derived from ammonia, primary Ci-to-Cc, alkyl amines and secondary Ci-to-C6 dialkyl amines. In the case of secondary amines, the amine can also be in the form of a 5- or 6-membered heterocycle containing one nitrogen atom. Amides derived from ammonia, Ci-to-C^ alkyl primary amides and Ci-to-Ci dialkyl secondary amides arc preferred. Amides of the compounds of formula (I) can be prepared according to conventional methods. Pharmaceutically acceptable amides can be prepared from compounds containing primary or secondary amine groups by reaction of the compound that contains the amino group with an alkyl anhydride, aryl anhydride, acyl halide, or aroyl halide. In the case of compounds containing carboxylic acid groups, the pharmaceutically acceptable esters are prepared from compounds containing the carboxylic acid groups by reaction of the compound with base such as triethylamine, a dehydrating agent such as dicyclohexyl carbodiimidc or carbonyl diimidazole, and an alkyl amine, dialkylamine, for example with methylamine, diethylamine, piperidine. They also can be prepared by reaction of the compound with an acid such as sulfuric acid and an alkylcarboxylic acid such as acetic acid, or with acid and an arylcarboxylic acid such as benzoic acid under dehydrating conditions as with molecular sieves added. The composition can contain a compound of the invention in the form of a pharmaceutically acceptable prodrug.
The term "pharmaceutically acceptable prodrug" or "prodrug," as used herein, represents those prodrugs of the compounds of the invention which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, initation, allergic response, and the like, commensurate with a reasonable benefit/risk ratio, and effective for their intended use. Prodrugs of the invention can be rapidly transformed in vivo to a parent compound of formula (I), for example, by hydrolysis in blood. A thorough discussion is provided in T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, V. 14 of the A.C.S. Symposium Series, and in Edward B. Roche, cd., Biorcversible Caniers in Drug Design, American Pharmaceutical Association and Pergamon Press (1987).
The invention contemplates pharmaceutically active compounds either chemically synthesized or formed by in vivo biotransformation to compounds of formula (I).

Determination of Biological Activity To determine the effectiveness of representative compounds of this invention as a7 nAChRs, the compounds of the invention were evaluated according to the T^HJ-DPPB binding or the [ H]-methyllycaconitine (MLA) binding assay (both measures of a7 NNR binding) and considering the [^Hl-cytisinc binding assay (measure of a4p2 interactions), which were performed as described below.
I Hl-Cvtisine binding
Binding conditions were modified from the procedures described in Pabreza LA, Dhawan, S, Kellar KJ, f3H]-Cytisine Binding to Nicotinic Cholinergic Receptors in Brain, Mol. Pharm. 39: 9-12, 1991. Membrane enriched fractions from rat brain minus cerebellum (ABS Inc., Wilmington, DE) were slowly thawed at 4 °C, washed and resuspcnded in 30 volumes of BSS-Tris buffer (120 mM NaCl/5 mM KCl/2 mM CaCl2/2 mM MgCl2/50 mM Tris-Cl, pH 7.4, 4 °C). Samples containing 100-200 |jg of protein and 0.75 nM [3H]-cytisine (30 C/mmol; Perkin Elmcr/NEN Life Science Products, Boston, MA) were incubated in a final volume of 500 |JL for 75 minutes at 4 °C. Seven log-dilution concentrations of each compound were tested in duplicate. Non-specific binding was determined in the presence of 10 |uM (-)-nicotine. Bound radioactivity was isolated by vacuum filtration onto prewetted glass fiber filter plates (Millipore, Bedford, MA) using a 96-well filtration apparatus (Packard histruments, Meriden. CT) and were then rapidly rinsed with 2 mL of ice-cold BSS buffer (120 niM NaCl/5 niM KCl/2 mM CaCl2/2 mM MgCh). Packai'd MicroScint-20® scintillation cocktail (40 yiL) was added to each well and radioactivity determined using a Packard TopCount® instrument. The ICso values were determined by nonlinear regression in Microsoft Excel" software. Kj values were calculated from the ICsos using the Cheng-Prusoff equation, where Kj = ICso/H-ILigandl/Ko].
r^HI-Methvllvcaconitine (MLA) binding
Binding conditions were similar to those for |3H|-cytisine binding. Membrane enriched fractions from rat brain minus cerebellum (ABS Inc., Wilmington, DE) were slowly thawed at 4 °C, washed and resuspended in 30 volumes of BSS-Tris buffer (120 mM NaCl 5 mM KCl, 2 mM CaCl2, 2 mM MgCb, and 50 mM Tris-Cl, pH 7.4, 22 °C).

Samples containing 100-200 |ug of protein, 5 nM |3H]-MLA (25 d/mmol; Perkin Elnicr/NEN Life Science Products, Boston, MA) and 0.1% bovine serum albumin (BSA, Millipore, Bedford, MA) were incubated in a final volume of 500 |uL for 60 minutes at 22 °C. Seven log-dilution concentrations of each compound were tested in duplicate. Non¬specific binding was determined in the presence of 10 |JM MLA. Bound radioactivity was isolated by vacuum filtration onto glass fiber filter plates pre wetted with 2% BSA using a 96-well filtration appaialus (Packard Instruments, Mcriden, CT) and were then rapidly rinsed with 2 mL of ice-cold BSS. Packard MicroScint-2()® scintillation cocktail (40 i^L) was added to each well and radioactivity was determined using a Packard TopCount" instrument. The ICso values were determined by nonlinear regression in Microsoft Excel" software. Ki values were calculated from the IC-sos using the Cheng-Prusoff equation, where Kj = IC-so/l-i-ILigandl/Kol.
I'Hl-DPPB binding
[^HJ-DPPB, r^HJ-(S,S)-2,2-dimethyl-5-(6-phenyl-pyridazin-3-yl)-5-aza-2-azonia-bicyclo|2.2.1]heptane iodide, binding to the a7 nAChR subtype was determined using membrane enriched fractions from rat brain minus cerebellum or human cortex (ABS Inc., Wilmington, DE). Pellets were thawed at 4°C, washed and resuspended with a Polylron at a setting of 7 in 30 volumes of BSS-Tris buffer (120 mM NaCl, 5 mM KCl, 2 mM CaCb. 2 mM MgCl2, and 50 mM Tris-Cl, pH 7.4, 4°C). Seven log-dilution concentrations of test compounds containing 100-200 |ug of protein, and 0.5 nM | H|-DPPB (62.8 Ci/mmol; R46V, Abbott Labs) were incubated in a final volume of 500 |ul for 75 minutes at 4°C in duplicate. Non-specific binding was determined in the presence of 10 |JM methyllycaconitine. Bound radioactivity was collected on Millipore Multiscreen® harvest plates FB presoaked with 0.3% PEI using a Packard cell harvester, washed with 2.5 ml ice-cold buffer, and radioactivity was determined using a Packard TopCount Microplate beta counter. IC.-so values were determined by nonlinear regression in Microsoft® Excel or Assay Explorer. Kj values were calculated from the ICjos using the Cheng-Prusoff equation, where K, = ICso/l+ILigandl/Kol. |-^H]-DPPB was obtained according to the preparation procedures described below.

|lV1ethvl--^H|2,2-Dimethvl-5-(6-phenvl-pvridazin-3-vl)-5-a7.a-2-azonia-bicyclo[2.2.l1hcptane; iodide Preparation
[Methyl-^H]2,2-dimethyl-5-(6-phenyl-pyridazin-3-yl)-5-aza-2-a7X)nia-bicyclo[2.2.1]hcptane; iodide used in the |^H|-DPPB binding assay above was prepared according to the following procedures.
Step 1: Preparation of t-Butyl (S.S)-5-(6-Phenyl-pyridazin-3-yl)-2,5-diaza-bicyclo[2.2.1|heptane-2-carboxvlate
Triethylamine (20 mL) was added to a suspension of t-butyl (S,S)-2,5-diazabicyclo|2.2.1]heptane-2-carboxylate (3.43 g, 17.3 mmol, Aldrich Chemical Company) and 3-chloro-6-phenylpyridazinc (3.30 g. 17.3 mmol, Aldrich Chemical Company) in toluene (50 mL) and the mixture was heated under nitrogen at 100 °C for 7 days. The dark mixture was cooled to room temperature, and the resulting precipitate was isolated by filtration, washed with toluene (15 mL) and dried under vacuum to provide the title compound as an off-white solid (3.00 g). The filtrate was concentrated and the residue wa purified by column chromatography on silica gel, eluting with ethyl acetate, to provide additional product (0.41 g, total yield 3.41 g, 56%): MS (DCi/NH3) m/z 353 (M+H)+.
Step 2: Preparation of (S,S)-2-Methvl 5-(6-phenvl-pvridazin-3-vl)-2,5-diaza-bicvclo|2.2.riheptane
The product obtained from Step 1 (3.41 g. 9.7 mmol) was dissolved in formic acid (20 mL) and treated with formalin (37% by weight, 1.0 g, 12.3 mmol). The mixture was heated at 100 °C for Ih, and the brown solution was cooled to room temperature and concentrated under vacuum. The residue was purified by column chromatogiaphy on silica gel, eluting with CH2C12 - CH30H - NH40H (95:5:1) to provide the title compound as an off-white solid (2.50 g, 96%): MS (DCI/NH3) m/z 267 (M+H)+.
Step 3: Preparation of I ^HI-(S,S)-2.2-Dimcthvl-5-(6-phenvl-pvridazin-3-vl)-5-aza-2-azonia-bicvclo|2.2■l jheptane iodide (I Hj-DPPB)
r^H]Methyl iodide in toluene (250 mCi in 0.1 mL, 85Ci/mmol, American Radiolabeled Chemicals, Inc.) was combined with a solution of the product obtained
92

from Step 2 in dichloromethane (0.788 mg, 2.96 mmole in 0.45 mL). The vial was capped and the mixture was allowed to react overnight al room temperature. Methanol was added and the solvents were evaporated to give 42 mCi. The product was taken up in methanol for HPLC purification.
Step 4: Purification by High Performance Liquid Chromatography (HPLC)
About 7 mCi of [ H]-DPPB was evaporated to dryness and the residue was dissolved in total about 4.5 ml acetonitrile:water:TFA (15:85:0.1). Approximately 0.9 mL per injection were made onto a Phcnomenex Luna C18(2) column (5 micron, 250 mm x 4.6 mm ID) using an Agilent HPLC system. |3Hj-DPPB was eluted by a gradient mobile phase from 10% B to 20% B in 20 min where Mobile Phase A= 0.1 % tritiuoroacetic acid in water and Mobile Phase B= 0.1% tritiuoroacetic acid in acetonitrile al a flow rate of approximately 1 mL/min. Peak detection and chromatograms were obtained with an Agilent variable wavelength UV detector set at 275 nm. The fractions containing |3H]-DPPB were collected at approximately 14 minutes using an Agilent fraction collector. The fractions were combined and the solvents were evaporated in vacuo. The residue was dissolved in 200 proof ethanol (2 mL) to give 0.7 mCi.
Step 5: Determination of Purity and Specific Activity
[^H|-DPPB was assayed using an Agilent 1100 series HPLC system consisting of a quaternary pump, an autosampler, and a photodiode airay UV detector. A Packard Radiomatic A 500 radioactivity detector was conncclcd to the HPLC system. For radiodetection, a 500 mL flow cell and a 3:1 ratio of Ultima-Flo M .scintillation cocktail to HPLC mobile phase were used. The analyses were performed using a Phenomenex Luna C'**(2) column (5 microns, 250 mm x 4.6 mm ID). The mobile phase consisted of a giadient starting with 10% B and ramping to 20% B in 20 minutes followed by ramping to 90% B in 1 minute and hold at 90% B for 9 minutes, where Mobile Phase A = 0.1 % trifluoroacetic acid in water and Mobile Phase B= 0.1% trifluoroacetic acid in acetonitrile. The flow rate was set at approximately I mL/min and the UV detection was set at 275 nm.
The radiochemical purity of [''H]-DPPB was found to be >98%. The specific activity was determined to be 62.78 Ci/mmol by mass spectroscopy.

Compounds of the invention had Kj values of from about 1 nanomolar to about 10 micromolar when tested by the [^H]-MLA assay, many having a K, of less than 1 micromolar. | H]-Cytisine binding values of compounds of the invention ranged from about 1 nanomolar to at least 100 micromolar. Alternatively, the K, value as measured by r H]-DPPB assay can be used in place of the Ki MLA-
Methods of the hivention
Compounds and compositions of the invention arc useful for modulating the effects of nAChRs, and more particularly a? nAChRs. In particular, the compounds and compositions of the invention can be used for treating and preventing disorders modulated by a? nAChRs. Typically, such disorders can be ameliorated by selectively modulating the a? nAChRs in a mammal, preferably by administering a compound or composition of the invention, either alone or in combination with another active agent, for example, as part of a therapeutic regimen. Also, some compounds of the invention possess affinity at the a4p2 nAChRs in addition to a7 nAChRs, and selective compounds with dual affinities at both receptor subtypes also are expected to have beneficial effects.
The compounds of the invention, including but not limited to those specified in the examples, possess an affinity for nAChRs, and more particularly a7 nAChRs. As a7 nAChRs ligands, the compounds of the invention can be useful for the treatment and prevention of a number of a7 nAChR-niediated diseases or conditions.
For example, a7 nAChRs have been shown to play a significant role in enhancing cognitive function, including aspects of learning, memory and attention (Levin, E.D., J. Ncurobiol. 53: 633-640, 2002). As such, a7 ligands are suitable for the treatment of cognitive disorders including, for example, attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia. Pick's Disease, dementia associated with Lewy bodies, and dementia associated with Down's syndrome, as well as cognitive deficits associated with schizophrenia.
In addition, a7-containing nAChRs have been shown to be involved in the neuroprotective effects of nicotine both in vitro (Jonnala, R. B. and Buccafusco, J. J., J. Ncurosci. Res. 66: 565-572, 2001) and in vivo (Shimohama, S. et al.. Brain Res. 779:

359-363, 1998). More particularly, neurodegeneration underlies several progressive CNS disorders, including, but not limited to, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis. Huntington's disease, dementia with Lewy bodies, as well as diminished CNS function resulting from traumatic brain injury. For example, the impaired function of a7 nAChRs by P-amyloid peptides linked to Alzheimer's disease has been implicated as a key factor in development of the cognitive deficits associated with the disease (Liu, Q.-S., Kawai, H., Berg, D. K., PNAS 98: 4734-4739, 2001). The activation of a7 nAChRs has been shown to block this neurotoxicity (Kihara, T. el al., J. Biol. Chem. 276: 13541-13546, 2001). As such, selective ligands that enhance a7 activity can counter the deficits of Alzheimer's and other neurodegenerative diseases.
Schizophrenia is a complex disease that is characterized by abnormalities in perception, cognition, and emotions. Significant evidence implicates the involvement of al nAChRs in this disease, including a measured deficit of these receptors in post¬mortem patients (Leonard, S. Eur. J. Pharmacol. 393: 237-242, 2000). Deficits in sensory processing (gating) are one of the hallmarks of schizophrenia. These deficits can be nomialized by nicotinic ligands that operate at the al nAChR (Adler L. E. et al. Schizophrenia Bull. 24: 189-202. 1998; Stevens. K. E. et al., Psychophaimacology 136: 320-327, 1998). Thus, al ligands demonstrate potential in the treatment schizophrenia.
Angiogenesis, a process involved in the giowth of new blood vessels, is important in beneficial systemic functions, such as wound healing, vascularization of skin grafts, and enhancement of circulation, for example, increased circulation around a vascular occlusion. Non-selective nAChR agonists like nicotine have been shown to stimulate angiogenesis (Hecschen, C. et al.. Nature Medicine 7: 833-839, 2001). Improved angiogenesis has been shown to involve activation of the al nAChR (Heeschen, C. et al, J. Clin. Invest. 110: 527-536, 2002). Therefore, nAChR ligands that are selective for the al subtype offer improved potential for stimulating angiogenesis with an improved side effect profile.
A population of al nAChRs in the spinal cord modulate serotonergic transmission that have been associated with the pain-relieving effects of nicotinic compounds (Cordero-Erausquin, M. and Changeux, J.-P. PNAS 98:2803-2807, 2001). The al nAChR ligands demonstrate therapeutic potential for the treatment of pain states.

including acute pain, post-surgical pain, as well as chronic pain states including inflammatory pain and neuropathic pain. Moreover, a7 nACHRs are expressed on the surface of primary macrophages that are involved in the inflammation response, and that activation of the a7 receptor inhibits release of TNF and other cytokines that trigger the inflammation response (Wang, H. et al Nature 421: 384-388, 2003). Therefore, selective a7 ligands demonstrate potential for treating conditions involving TNF-mediated diseases, for example, rheumatoid arthritis, Crohn's disease, ulcerative colitis, inflammatory bowel disease, organ transplant rejection, acute immune disease associated with organ transplantation, cloronic immune disease associated with organ transplantation, septic shock, toxic shock syndrome, sepsis syndrome, depression, and rheumatoid spondylitis.
The mammalian sperm acrosomc reaction is an cxocytosis process important in fertilization of the ovum by sperm. Activation of an a? nACliR on the sperm cell has been shown to be essential for the acrosome reaction (Son. J.-H. and Meizel, S. Biol. Rcproduct. 68: 1348-1353 2003). Consequently, selective a7 agents demonstrate utility for treating fertility disorders.
Compounds of the invention are particularly useful for treating and preventing a condition or disorder affecting cognition, ncurodcgeneration, and schizophrenia.
Cognitive impairment associated with schizophrenia often limits the ability of patients to function normally, a symptom not adequately treated by commonly available treatments, for example, treatment with an atypical antipsychotic. (Rowley, M. et al., J. Med. Chcm. 44: 477-501, 2001). Such cognitive deficit has been linked to dysfunction of the nicotinic cholinergic system, in particular with decreased activity at al receptors. (Friedman, J. 1. et al., Biol Psychiatry, 51: 349-357, 2002). Thus, activators of a7 receptors can provide useful treatment for enhancing cognitive function in schizophrenic patients who are being treated with atypical antipsychotics. Accordingly, the combination of an al nAChR ligand and an atypical antipsychotic would offer improved therapeutic utility. Specific examples of suitable atypical antipsychotics include, but are not limited to, clozapine, risperidone, olanzapine, quietapinc, ziprasidonc, zotepinc, iloperidone, and the like.
Actual dosage levels of active ingredients in the pharmaceutical compositions of

this invention can be varied so as to obtain an amount of the active compound(s) that is effective to achieve the desired therapeutic response for a particular patient, compositions and mode of administration. The selected dosage level will depend upon the activity of the particular compound, the route of administration, the severity of the condition being treated and the condition and prior medical history of the patient being treated. However, it is within the skill of the art to start doses of the compound at levels lower than required to achieve the desired therapeutic effect and to gradually increase the dosage until the desired effect is achieved.
When used in the above or other treatments, a therapeutically effective amount of one of the compounds of the invention can be employed in pure form or, where such forms exist, in pharmaceutically acceptable salt, ester, amide or prodrug form. Alternatively, the compound can be administered as a pharmaceutical composition containing the compound of interest in combination with one or more pharmaceutically acceptable carriers. The phrase "therapeutically effective amount" of the compound of the invention means a sufficient amount of the compound to treat disorders, at a reasonable benefit/risk ratio applicable to any medical treatment. It will be understood, however, that the total daily usage of the compounds and compositions of the invention will be decided by the attending physician within the scope of sound medical judgment. The specific therapeutically effective dose level for any particular patient will depend upon a variety of factors including the disorder being treated and the severity of the disorder; activity of the specific compound employed; the specific composition employed; the age, body weight, general health, sex and diet of the patient; the time of administration, route of administration, and rate of excretion of the specific compound employed; the duration of the treatment; drugs used in combination or coincidental with the specific compound employed; and like factors well-known in the medical arts. For example, it is well within the skill of the art to start doses of the compound at levels lower than required to achieve the desired therapeutic effect and to gradually increase the dosage until the desired effect is achieved.
The total daily dose of the compounds of this invention administered to a human or lower animal range from about 0.010 mg/kg body weight to about 1 g/kg body weight. More preferable doses can be in the range of from about 0.010 mg/kg body weight to about 100 mg/kg body weight. If desired, the effective daily dose can be divided into

multiple doses for purposes of administration. Consequently, single dose compositions may contain such amounts or submultiples thereof to make up the daily dose.
Compounds of the invention are a7 nAChRs ligands that modulate function of a7 nAChRs by altering the activity of the receptor or signaling. The compounds can be inverse agonists that inhibit the basal activity of the receptor or antagonists that completely block the action of receptor-activating agonists. The compounds also can be partial agonists that partially block or partially activate the a7 nAChR receptor or agonists that activate the receptor. Binding to a7 receptor also trigger key signaling processes involving various kinases and phosphatases and protein-protein interactions that are important to effects on memory, cytoprotection, gene transcription and disease modification. Therefore, the administration of a therapeutically effective amount of a compound of formula (I) to a mammal provides a method of selectively modulating the effects of a4(32, a7, or both a4p2 and a7 nicotinic acetylcholine receptors.
Furthermore, the administration of a therapeutically effective amount of a compound of formula (I) toa mammal provides a method of treating or preventing a condition or disorder selected from the group consisting of attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia. Pick's Disease, dementia associated with Lewy bodies, dementia associated with Down's syndrome, amyotrophic lateral sclerosis. Huntington's disease, diminished CNS function associated with traumatic brain injury, acute pain, post-surgical pain, chronic pain, inflammatory pain, neuropathic pain, infertility, need for new blood vessel growth associated with wound healing, need for new blood vessel growth associated with vascularization of skin grafts, and lack of circulation, more particularly circulation around a vascular occlusion, rheumatoid arthritis, Crohn's disease, ulcerative colitis, inflammatory bowel disease, organ transplant rejection, acute immune disease associated with organ transplantation, chronic immune disease associated with organ transplantation, septic shock, toxic shock syndrome, sepsis syndrome, depression, and rheumatoid spondylitis. More prefered, the administration of a therapeutically effective amount of a compound of formula (I) toa mammal provides a method of treating cognitive disorders, neurodegeneration, and schizophrenia. Furthermore, compounds of formula (I) may also be administered in combination with an atypical antipsychotic.

It is understood that the foregoing detailed description and accompanying examples are merely illustrative and are not to be taken as limitations upon the scope of the invention, which is defined solely by the appended claims and their equivalents. Various changes and modifications to the disclosed embodiments will be apparent to those skilled in the art. Such changes and modifications, including without limitation those relating to the chemical structures, substituents, derivatives, intermediates, syntheses, formulations, or methods of use of the invention, may be made without departing from the spirit and scope thereof.

WHAT IS CLAIMED IS:
1. The compound of formula (I).

or a pharmaceutically acccplable salt, ester, amide, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N^-0 ;
R is hydrogen, alkyl, cycloalkyiaikyl and arylalkyl: L is selected from the group consisting of O, S, and -N(Ra)-: Ar' is a 6-membered aryl or 6 membercd heteroaryl ring; and Ar' is a bicyclic heteroaryl; and
Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar2 is
then L is O or S.
2. The compound of claim 1, wherein Ar' is selected from the group consisting of:



wherein Rj, R2, R3, R4 and R5 are independently selected from the group consisting of acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy. alkoxyalkyl, alkoxycarbonyl, alkoxyimino, aikoxysulfonyl, alkyl, alkylsulfonyl. alkynyl. amino, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto. nitro, ihioalkoxy, -NRpRj, (NRgRj)alkyl, (NRgR,)alkoxy, (NRgR,)carbonyl, and (NRgRj)sulfonyl;
Rg and R, are each independently selected from the gioup consisting of hydrogen
and alkyl.
3. The compound of claim 1, wherein Ar~ is selected from the group consisting of



wherein Zi, Z?, Z3 and Z4 are each independently nitrogen or are carbon, wherein the carbon atom is optionally substituted with a substituent selected from the group consisting of hydrogen, halogen, alkyl, -ORc -alkyl-ORc -NRjRe, and -alkyl-NRjRe;
Rb is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl;
Re is alkyl;
Rd and Re are each independently selected from the group consisting of hydrogen and alkyl,
Rb and R7 are each independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino. alkoxysulfonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfonyl, alkynyl, carboxy, cyano, formyl, haloalkoxy, haloalkyl, halo, hydrogen, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy, -NRgRj, (NRgRi)alkyl, (NRgR|)alkoxy, (NReRj)carbonyl, and (NRgRi)sulfonyl; Rg and Rj, are each independently selected from the group consisting of hydrogen and alkyl.
4. The compound of claim 2, wherein
A is N; R is methyl or hydrogen; L is O; n is 2; and Ar" is selected from the group of consisting of:

5. The compound of claim 2, wherein
A is N; R is methyl or hydrogen; L is O; n is 2; Ar' is

6. The compound of claim 2, wherein
A is N; R is methyl or hydrogen; L is O; n is 2; Ar' is
Ar' is

7. The compound of claim 1, selected from the group consisting of:
5-{6-[(endo)-8-methyl-8-aza-bicyclo| 3.2.1 |oct-3-yloxy|-pyridazin-3-yl )-lH-
indole;
(endo;)-3-(6-benzo[b|thiophen-5-yl-pyridazin-3-yloxy)-8-methyl-8-aza-bicyclo|3.2.r] octane;
(endo)-3-[6-(benzofuran-5-yl)-pyridazin-3-yloxyl-8-mcthyl-8-aza-bicyclo|3.2.1|octane;
6-{6-|(endo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxyl-pyridazin-3-yl}-lH-
indole;
5-{6-|((endo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxyl-pyridazin-3-yl}-iH-
indazolc;
l-methyl-5-{6-|(endo)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy|-pyridazin-3-
yl}-lH-indole;
5-{6-|(endo)-8-methyl-8-aza-bicycIo|3.2.1 |oct-3-yloxy|-pyridazin-3-yl }-2-

trifluoromethyl-1 H-indole;
5-{6-[(endo;)-8-melhyl-8-aza-bicyclo[3.2.1]ocl-3-yloxy|-pyridazin-3-yl}-lH-indole;
5-{5-[(endo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxy]-pyiidin-2-yl}-l H-indole;
(endo;)-3-(6-benzo[b]thiophen-5-yl-pyridin-3-yloxy)-8-melhyl-8-aza-bicyclo[3.2.1]oclane;
5-{5-|(exo)-8-methyl-8-aza-bicyclo(3.2.1|ocl-3-yloxy]-pyridin-2-yl}-lH-iiidolc;
(exo)-3-f6-(benzofuran-5-yl)-pyridin-3-yloxy)-8-mcthyl-8-aza-bicyclo[3.2.1|octane;
5-{5-[(exo;)-8-methyl-8-aza-bicyclo[3.2.11ocl-3-yloxyl-pyridin-2-yl}-lH-indazolc;
5-{5-[(exo)-8-methyl-8-aza-bicyclol3.2.1 Joct-3-yloxy]-pyridin-2-yl )-2-trifluoromethyl-1 H-indole;
4-{5-[(exo)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy|-pyridin-2-yl}-lH-indole;
5-{6-[(endo)-8-methyl-8-aza-bicyclo|3.2.1|ocl-3-yloxyl-pyridin-3-yl}-lH-indole;
(endo)-3-(5-benzo[b]thiophen-5-yl-pyridin-2-yloxy)-8-methyl-8-aza-bicyclo|3.2.1]octane;
5-{6-[(exo)-8-methyl-8-aza-bicyclo| 3.2. l]oct-3-yloxyj-pyridin-3-yl}-l H-indole;
[6-(lH-indol-5-yl)-pyridin-3-yl|-l(endo)-8-methyl-8-aza-bicyclo[3.2.1|oct-3-yl|-amine;
[6-(benzofuran-5-yl)-pyridin-3-yl]-|(endo)-8-inethyl-8-aza-bicyclo[3.2.1|oct-3-yl)-aminc;
[(endo)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl|-|6-(2-trifluoromethyl-lH-indol-5-yl)-pyridin-3-yl|-amine;
[6-(lH-indazol-5-yl)-pyridin-3-ylJ-((endo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-
ylj-amine;
f6-(lH-indol-4-yl)-pyridin-3-yl|-|(endo)-8-mcthyl-8-aza-bicyclo[3.2.11ocl-3-ylJ-
aminc;
|(endo)-8-aza-bicyclo[3.2.1]ocl-3-yll-|6-(lH-indol-5-yl)-pyridin-3-yl]-amine ; 14-( lH-indol-5-yl)-phenyl]-[(endo)-8-mcthyl-8-aza-bicyclo|3.2.1 loct-3-yll-amine; |4-(lH-indazol-5-yl)-phcnyl|-[(endo)-8-methyl-8-aza-bicyclo[3.2.11oct-3-yl]-
amine;
[(endo)-8-mcthyl-8-aza-bicyclo[3.2.1]oct-3-yll-f4-(l-melhyl-lH-indol-5-yl)-
phenyl]-amine;

(4-benzo|b]thiophen-5-yl-phenyl)-|(endo;)-8-methyl-8-aza-bicycio[3.2.1]oct-3-yl]-amine;
[4-(benzofuran-5-yl)-phenyl]-[(endo)-8-methyl-8-aza-bicyclo[3.2.1|oct-3-yl]-aminc;
f4-(lH-indol-4-yl)-phenyl]-[(endo)-8-methyl-8-aza-bicyclo[3.2.1|oct-3-yll-aminc;
|3-(lH-indol-5-yl)-phenyl]-(endo)-8-i-ncthyl-8-aza-bicyclo|3.2.1]oct-3-yl|-aminc;
[3-(lH-indol-4-yl)-phenyl]-[(endo)-8-mcthyl-8-aza-bicyclof3.2.1|oct-3-ylJ-amine;
5-{ 6-[((endo)-8-methyl-8-aza-bicyclo[3.2.1 ]ocl-3-yloxy]-pyridazin-3-yl }-2-trinuoromethyl-lH-indole;
4-{6-|(end)-8-methyl-8-aza-bicyclo|3.2.1 |oct-3-yloxy]-pyridazin-3-yl}-lH-indolc;
5-{6-[(exo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxy|-pyridin-3-yl}-lH-indole;
5-{6-[(exo)-8-melhyl-8-aza-bicyclo|3.2.11oct-3-yloxyl-pyridm-3-yl}-2-trifluoromethyl-1 H-indole;
4-{6-[((exo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxy|-pyridazin-3-yl)-lH-indole;
6-{5-|(endo)-8-methyl-8-aza-bicyclo|3.2.1joct-3-yloxy]-pyridin-2-yl)-l H-indole;
5-{5-|(endo;)-8-methyl-8-aza-bicyclo| 3.2. lloct-3-yloxy|-pyrazin-2-yI 1-1 H-indole;
4-{5-l(end9)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy|-pyrazin-2-yl|-l H-indole;
6-{5-[(endo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-yIoxy]-pyrazin-2-yl]-l H-indole;
|6-(lH-indol-6-yl)-pyridin-3-yll-|((endo;)-8-mcthyl-8-aza-bicyclo|3.2.11oct-3-yn-
amine;
5-{6-|(endo)-9-methyl-9-azabicyclo[3.3.1|nonan-3-yloxy]pyridazin-3-yl}-lH-
indole;
(endo)-3-[6-(benzo|b|thiophen-5-yl)pyridazin-3-yloxy]-9-methyl-9-azabicyclo[3.3.1]nonane;
5-{5-[(endo;)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxyl-pyrazin-2-yl}-lH-pyiTolo[2,3-bJpyridine;
5-{5-[(exo)-8-methyl-8-aza-bicyclo|3.2.11oct-3-yloxy|-pyridin-2-yl}-lH-pyrrolo|2.3-bJpyridine;
5-{5-|(exo)-8-methyl-8-aza-bicyclo|3.2.1|oct-3-yloxy|-pyridin-3-yl}-l H-indole;
5-{5-I(exo)-8-methyl-8-aza-bicycIo(3.2.1|ocl-3-yloxy|-pyrazin-2-yi)-lH-indolc;
4-{5-[(exo)-8-methyl-8-aza-bicyclo|3.2.11oct-3-yloxy|-pyrazin-2-yl)-lH-indole;

6-{5-((endo)-8-methy]-8-aza-bicyclo|3.2.rjoct-3-yloxyl-pyrazin-2-yl)-IH-indole. (endo)-A'-(5-(lH-Indol-5-yl)pyridin-3-yl)-8-methyl-8-a/abicyclo| 3.2.1 ]octan-3-amine;
(endo)-A^-(5-(lH-Indol-4-yl)pyridin-3-yl)-8-methyl-8-azabicyclo|3.2.1]octan-3-amine;
(endo)A'-CS-C lH-Indol-6-yl)pyridin-3-yl)-8-melhyl-8-azabicyclo|3.2.1 loctan-3-amine;
(endo)-A-{5-[2-(trifluoromethyl)-lH-indol-5-yl]pyridin-3-yl}-8-Mclhyl-8-azabicyclol 3.2.1 ]octan-3-amine;
5- {5-[(endo)-8-Methyl-8-azabicycIo| 3.2.1 |octan-3-yloxyJpyridin-2-yl} -1H-pyrrolo|2,3-blpyridinc;
5-{5-[(endo)-8-Methyl-8-azabicyclo|3.2.1]octan-3-yloxy]pyridin-2-yl}indolin-2-one;
5- {5-[(endo)-8-Azabicyclo[3.2.1 ]octan-3-yloxy ]pyridin-2-yl}-1 H-indole;
{/Rir,55,<^.v)-3-(6-(lH-Indol-5-yl)pyridin-3-yloxy)-8-methyl-8-azabicyclo[3.2. IJoctane 8-oxide;
(,ir,5.S,8r)-3-(6-(lH-Indol-5-yl)pyridin-3-yloxy)-8-methyl-8-azabicyclo|3.2.I]octane 8-oxide;
4-{5-|(endo)-8-Azabicyclo| 3.2.1 |octan-3-yloxy|pyridin-2-yl}-lH-indole;
5-{5-|(endo)-8-Azabicyclo[3.2.11octan-3-yloxy|pyridin-2-yl}-lH-indolc;
5-{5-[(endo)-8-Azabicyclor3.2.r|octan-3-yloxy|pyridin-2-yl}indolin-2-one;
5-{5-|(endo)-8-Azabicyclo[3.2.1|octan-3-yloxy|pyridin-2-yl}-lH-pyrrolo[2,3-blpyridine;
5-{5-[(endo)-8-Azabicyclo[3.2.11octan-3-yloxy|pyridin-2-yl}-lH-pyrrolo|2,3-bjpyridine.
8. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
9. A method of selectively modulating the effects of a7 nicotinic acetylcholine receptors, nicotinic acetylcholine receptors, or both a7 and a4|32 nicotinic acetylcholine receptors in a mammal comprising administering an effective amount of a

compound of claim 1.
10. A method of treating or preventing a condition or disorder selected from the group consisting of attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia. AIDS dementia. Pick's Disease, dementia associated with Lewy bodies, dementia associated with Down's syndrome, amyotrophic lateral sclerosis, Huntington's disease, diminished CNS function associated with traumatic brain injury, acute pain, post-surgical pain, chronic pain, inflammation, inflammatory pain, neuropathic pain, infertility, need for new blood vessel growth associated with wound healing, need for new blood vessel growth associated with vascularization of skin grafts, and lack of circulation, rheumatoid arthritis, Crohn's disease, ulcerative colitis, inflammatory bowel disease, organ transplant rejection, acute immune disease associated with organ transplantation, chronic immune disease associated with organ transplantation, septic shock, toxic shock syndrome, sepsis syndrome, depression, and rheumatoid spondylitis, comprising the step of administering a compound of claim 1.