GAS AND LIGHT PROOF, DOUBLE-SHELL BLISTER PACKS FOR MEDICINAL CONTENTS
Field of the Invention
[0001] The present invention is related t o a high gas barrier and light proof, double-shell
blister pack for medicinal contents, such as medication and analogous pharmaceutical products.
The present invention also discloses a process for the production of this blister pack.
State of the Art
[0002] Blister packs are well known by those skilled in the art. They are produced on blister
lines for the pharmaceutical industry t o pack for example tablets and capsules by forming a
packaging film t o a cavity form, filling the tablet and sealing it by a lidding foil. If no gas barrier
is needed, in particular no aluminum layer, usual films such as (PVC, PVDC/PVC, PP, PS, etc.) are
easily thermoformable and constitute the bottom film of a single-shell blister in which cavities
of a large variety of sizes can be thermoformed.
[0003] US 5,011,019 discloses a single-shell blister pack with lid comprising an aluminium
layer (Fig. l ) and a double-shell (Fig.2) blister packaging without aluminium barrier layer. The
plastic film is heated and formed by air pressure or by a plug to form the cavity by press-trough
process (PTP). Since no aluminum layer is present here, high forma bilities can be achieved
leading t o a small blister size.
[0004] For blister packaging with total gas and light barrier requirements, laminates with
an aluminum layer are required. The presence of such an aluminum layer considerably limits the
depth of the cavities in a deep-drawing process since the elongation-at-break is conditioned by
this aluminum layer. Therefore, a process called "stretch cold forming" is used. In this process,
the periphery of a future cavity is maintained in place by clamping while the cavity is deepdrawn.
[0005] For single-shell blister packs with aluminum layer, it is state of the art that the
bottom foil is formed and the lid foil is unformed. Forming tools form the Al laminate according
to a cold forming process by means of plugs and a clamping. The multiaxial deformability is
nevertheless limited. Single-shell blisters of this type are notably disclosed in EP 1 780 005 Bl,
EP 1 733 872 Al, WO 2007/042174 Al, WO 2007/057081 Al and US 2010/0155288 Al.
[0006] A well-known example of a single-shell blister pack according to the prior art has
the following structure: polyamide (PA) 25 miti / Al 45 miti / PVC 60 miti . This structure can be
multiaxially stretch-coldformed by about 30 %.
[0007] EP 0 637 285 Bl discloses a stretch-formed single-shell blister pack for freeze drying
applications with a plurality of compartments made from a stretch-formable multilayer
structure comprising a metal layer of 8 t o 80 miti and a plastic support layer of biaxially oriented
polyamide on each side having a thickness between 20 and 30 miti . The lid is not stretch-formed
and comprises an aluminium layer from 15 to 25 miti . The blister pack is aimed for a process
where a liquid is poured into the cavity and freeze dried, which requests a high resistance against
temperature differences without curling and suggests the use of symmetrical film structures.
[0008] DE 102011001929 (Amcor) discloses a single-shell blister packaging using
amorphous PET of a preferred thickness between 200 and 300 miti and a tensile strength at break
much lower than 200 N/mm 2 (MPa). Typical non-oriented PET (A-PET) for thermoforming
exhibits a tensile strength at break between 55 and 75 N/mm 2 (MPa) t o allow thermoformability
- see http://en.wikipedia.org/wiki/Polyethylene terephthalate. Furthermore, the multilayer
structures disclosed in DE 102011001929 do not have two or more support layers of oriented
polymer layer with a tensile strength at break higher than 200 N/mm 2 (MPa), and in particular
no aluminum layer sandwiched between those support layers.
Aims of the Invention
[0009] The present invention aims t o provide a double-shell packaging for medicinal
contents exhibiting a total light barrier and a high gas barrier, wherein the only gas diffusion is
limited to the edges.
[0010] The present invention also aims t o optimize the size of the double-shell packaging
by considerably reducing the ratio film laminate versus medicinal content by adapting the
double-shell cavity size closely to the capsule or tablet size, thereby reducing the global size of
the blister packaging and of the over-packaging with a logical positive effect on the global CO2
balance.
[0011] The present invention further provides a process for the production of a spaceefficient
double-shell blister according to the invention.
Summary of the Invention
[0012] The present invention discloses a double-shell blister packaging for medicinal
contents comprising one or more cavity(ies) of an optimized shape for the medicinal content,
said double-shell packaging being the assembly of a first and a second multilayer structures
sealed to each other via one or more seal layer(s), each multilayer structure comprising one or
more aluminum layer(s) with a thickness of at least 20 miti, preferably 30 miti, and two or more
support layers, wherein said two or more support layers have a tensile strength at break
measured in machine and transversal direction of 200 N/mm 2 or more, and an elongation at
break of 50 %or more, preferably 70 %or more, measured according to EN ISO 527-3 published
in 1995; sample type 2, part 1-6, each of said multilayer structures comprising cavities which,
arranged face to face, enclose in use said medicinal content.
[0013] Particular embodiments of the present invention comprise one or more of the
following features:
- the one or more aluminium layer(s) is/are sandwiched between the two or more support
layers;
- the ratio of the volume of the cavity to the volume of the medicinal content is comprised
between 1.8 and 1, prefera bly between 1.6 and 1.1, and most prefera bly between 1.5 and
1.2;
- the stress/strain curves measured on said support layer present a positive slope for the
measurement of the strain hardening according to EN ISO 527-3 published in 1995, sample
type 2, part 1-6;
- the thickness of the one or more aluminium layer(s) within the one or more cavity(ies), due
to the stretch-coldforming process, represents at least 30 % of the thickness of the one or
more aluminium layer(s) in the multilayer structure in the periphery of said cavities;
- the blister is of a tearable push-through or a peelable type comprising one or more seal
layer(s) selected from the group consisting of heat-seal lacquer with a thickness of 15 miti or
less, preferably 10 miti or less, a seal-initiation temperature determined by welding trials of
125 °C or less, preferably 110 °C or less, and a melting temperature determined by differential
scanning calorimetry of 125 °C or less, preferably 120 °C or less, and most preferably of 115 °C
or less, measured under a heating speed of 20 °C/min between 50 and 150 °C and
represented by the peak maximum of the second run;
- the blister is of a tearable push-through or a peelable type comprising one or more seal
layer(s) comprising coextruded polymer films and extrusion coatings with a thickness of
50 miti or less, preferably 35 miti or less, a seal-initiation temperature determined by welding
trials of 135 °C or less, preferably 120 °C or less, and a melting temperature determined by
differential scanning calorimetry of 135 °C or less, preferably 125 °C or less, and most
preferably of 115 °C or less, measured under a heating speed of 20 °C/min between 50 and
150 °C and represented by the peak maximum of the second run;
- the seal layer for the peelable blister has a peel strength comprised between 2 and
10 N/15mm;
- the seal peelable seal layer comprises LLDPE, poly-l-butene and inorganic filler material;
- the seal layer for the tearable blister type is selected from the group consisting of a linear
low-density polyethylene of a density between 0.902 and 0.925 g/cm 3, partially or entirely
neutralized ionomer, EMA, EBA, polyethylene obtained by metallocene catalysis, ethylene
vinyl acetate, polyethyleneterephtalate glycol;
- the peelable seal layer for the peelable blister type comprises compositions selected from
the group consisting of polyolefin blends and/or copolymers of modified ethylene acrylate,
blends of linear low-density polyethylene or polyethylene obtained by metallocence catalysis
and polybutylene;
- the peelable seal layer for the peelable blister comprises lacquer compositions selected from
the group consisting of phenoxy resins, blends of copolymers of methacrylic ester, olefins
and ethylidennorbornen as binder, blends of polybutylmetacrylate, polybutyl-ethacrylate
and acrylic resins as binder, tackifier based on alphamethylstyrene, maleic acid anhydride
modified copolymers of vinylacetat and vinylchloride and water-based dispersions based on
ethylenevinylacetate, ethylene acrylic acid and metacrylic acid and salts thereof;
- said multilayer structures additionally comprise two or more adhesive or tie layers selected
from the group consisting of EAA, ionomers, EMA and EBA.
[0014] The present invention further discloses a process for the manufacturing of the
blister packaging according to the invention, comprising the following steps:
- supplying a first and second multilayer structures comprising one or more aluminium layer(s)
with a thickness of at least 30 miti and two or more support layers, said multilayer structures
having a multidirectional deformability of 35 %or more;
- stretch-cold forming of said first and second multilayers to form one or more cavity(ies);
- filling said one or more cavity(ies) of one of the first or second multilayer structure with the
medicinal content;
- sealing the first and second multilayer structures face t o face;
- cutting the sealed multilayer into blister packaging units;
- conditioning in over-pack boxes or bags.
[0015] The process according to the invention may comprise an additional step of cutting
a weakening line or a tear notch into the first and/or second multilayer structure(s) t o allow a
push-through opening or a tear opening.
Brief Description of the Drawings
[0016] Fig. 1 to 3 are schematic representations of the cross-diffusion phenomenon in
single-shell blister pack according to the prior art. Since such single-shell packaging for medicinal
contents have a lid and a shell both comprising aluminium layer, no other diffusion than crossdiffusion
is possible.
[0017] Fig. 4 represents the comparisons between single-shell blister packs of the prior art
and double-shell blister packs according t o the invention. Due to stretch-cold forming, the global
size of the blister pack can be considerably reduced.
[0018] Fig. 5 represents a top view of the dimensions between a prior art single-shell pack
with lid (b) for a capsule 00 which is 23.3 mm long with a diameter of 8.5 mm (which was taken
as reference for the calculations in Table 2) and the dimension of the double-shell pack according
to the invention (a).
[0019] Fig. 6 represents a first configuration of the double-shell blister pack according to
the invention, wherein the medicinal content (a capsule 00) is packed in a double-shell structure
where the aluminium layer is situated between two support layers and one seal layer. The
adhesive, primer or extrusion coated tie layers are not represented.
[0020] Fig. 7 represents a second configuration of the double-shell blister pack according
to the invention, wherein the medicinal content (a capsule 00) is packed in a double-shell
structure where the aluminium layer is sandwiched between two support layers. Again, the
possible adhesive, primer or extrusion coated tie layers are not represented.
[0021] Fig. 8 represents a burst pressure test of the multilayer structure used for the
double-shell blister according to the present invention.
[0022] Fig. 9 represents the process scheme for the production of the double-shell blister
according t o the invention.
[0023] Key
1. Double-shell blister pack
2. Support layer
3. Seal layer
4. Aluminum layer
5. Medicinal content
6. Forming station
7. Filling station
8. Sealing station
9. Cutting station
10. Packing station
Detailed Description of the Invention
[0024] Tablet blisters are produced on blister lines for the pharmaceutical industry to pack
a medicinal content, for example tablets and capsules, by forming a multilayer packaging film to
a cavity form, filling the medicinal content and sealing it by a lidding foil. The presence of an
aluminium layer with a thickness of at least 30 miti within the multilayer of the bottom and of
the lidding foil guarantees a total gas and light barrier, if necessary.
[0025] The expression "medicinal content" in the present invention has to be understood
in its largest sense and comprises tablets, pills, capsules but also contents which are not strictly
considered for medical use but requesting a high gas barrier.
[0026] A first target of the present invention is to create a double-shell gas-tight blister,
comprising an aluminium barrier layer of at least 20 miti, preferably 30 miti, with a comparable
cavity size as an ordinary double-shell thermoform blister (without aluminium layer as gas and
light barrier).
[0027] To reach this target, the present invention uses a multilayer laminate comprising
an aluminium layer with an increased multiaxial deformability of at least 35 %, preferably of at
least 40 %. Two multilayer structures with increased multiaxial deformability can be cold-formed
(stretch-cold forming) creating cavities in each part (top and bottom) that are arranged
symmetrically t o each other, those cold-formed parts being assembled by sealing after having
been filled with their medicinal content. The size of such a double-shell configuration is
considerably reduced compared t o a single shell with a flat lid. The requested quantity of
multilayer structure can be reduced by at least 50 %, and preferably by at least 70 %- see Fig. 5
and Table 2. The size of the cavity is optimized and just slightly bigger than the size of the
medicinal content by about 5 to 60 %, preferably 10 to 40 %and more preferably 10 to 30 %.
[0028] A burst test t o test multiaxial deformability is performed by preparing a strip with
a width of 20 cm out of the multilayer structure, which is introduced under a calotte, in case of
bursting during the test, the testing time has to be adjusted and the tests have to be repeated
over the whole width of the strip. The measured values have t o be averaged and the standard
deviation is being calculated (see Fig. 8).
[0029] The good formability of a standard cold-formed multilayer structure is achieved by
supporting the weakest layer in the laminate, i.e. the aluminium foil, by means of at least two
strong plastic layers. Oriented polyamide (oPA) film of 25 miti is generally used for that purpose
as well as other plastics having a tensile strength at break in machine transversal direction of at
least 200 N/mm 2 and an elongation at break of at least 50 %, preferably at least 70 %, measured
according t o EN ISO 527-3 published in 1995, sample type 2, parts 1-6.
[0030] The present invention discloses the use of at least two or more of such stiff polymer
films, either both on one side of the aluminium layer or sandwiching the aluminium layer.
[0031] Non-limitative examples of such stiff polymer layer are oriented polymer layer such
as oPET's (>230 M Pa in M D und TD), oPPS, oPS, oEVOH, or non-oriented aromatic polyamides
(aramid) or PEEK. Preferred polymers are specific polyamide formulations developed for higher
stiffness applications. An example for a typical structure of a final laminate according to the
invention is (tie or adhesive layers are not mentioned here):
oPA 25 miti (outside)/ Al 60 miti /oPA 25 miti /PETG 35 miti (inside)
In this structure, oPA works as support layer, aluminium as barrier layer and PETG as seal layer.
[0032] The use of such relatively thick multilayer structures requests high sealing
temperatures on the jaws since the heat has to cross several layers before it reaches the seal
layer. This creates a phenomenon called the "Hot Tack Issue" where the air in the cavity is
overheated, thus increasing the pressure in the cavity. At that stage, the seal layer is still molten
and air penetrates the periphery of the cavity leading to a poor seal and cross-diffusion barrier.
[0033] To overcome this problem, high-viscosity melt at the necessary seal temperature is
needed. The most convenient seal layers are therefore combinations of a low seal temperature
and high molecular weight, (high viscous seal layer), as thin as possible to avoid an insulation
effect. Non-limitative examples for such films are PETG 35 miti, various LLDPE versions with
densities between 0.902 and 0.925 g/cm 3 or multilayer films based on it, as well as ionomers
films/coatings. High MW lacquers or thin coatings (1-10 miti ) are possible alternatives (see
examples) as seal layer as well as highly mineral filled coatings since they have a high-melt
viscosity. The key features for sealing layer are melting point determined by DSC and sealinitiation
temperature which should be lower than 125 °C, preferably lower than 120 °C and
even lower than 115 °C if possible.
[0034] To determine the seal-initiation temperature (SIT), seal trials are started at a
temperature low enough t o avoid any seal (seal strength = 0 N/15 mm), then the temperature
is progressively increased (5 or 10 °C steps) and when a seal occurs, the strength is measured
and the SIT is considered as determined above 2 N/15 mm seal strength.
[0035] The double-shell blister packaging according t o the invention needs an opening
mechanism chosen between peeling, pushing-through or tearing.
[0036] The tear-open solution can be achieved by the use of appropriate plastic that
breaks easily and thin enough Al layers. Such plastic structures are mostly oriented or
intrinsically brittle. As non-limitative examples, mention may be made of PETG, oPA, oPET, etc.
[0037] Another option t o achieve "easy tear" is specific weakening by laser-cutting (in
distinct areas and trough specific layers only) or mechanically (punching/scratching at specific
area into specific layers only) at the blister production line after forming or during the laminate
production process. These techniques are well known by those skilled in the art.
[0038] The peelable solution often uses seal layer composed of a matrix polymer and a
dispersed-phase inorganic or organic material, that substantially weakens the cohesive strength
leading to an easy opening. Well-known examples are e.g. polyethylene blended with poly-1-
butene (PE/PB-1) or polyethylene with talcum added. For lacquers, debonding agents are used
but adhesively-failing structures can possibly be used.
[0039] The peel and seal strength is given in N/15 mm. The test procedure generates a
cross seal at appropriate temperature using sealing jaws of 10 mm, the sealing pressure is
50 N/cm 2, +/- N/cm 2, sealing time 0.5 sec. To measure the peel or seal force via a testing
machine, the test velocity is 100 mm/min and the takedown angle 90 ° .
[0040] The push-through solution needs t o take care on the tablet, which should not break,
and therefore needs a cavity that must be sufficiently weak or breaking easily. This is an opposite
requirement to the high-strength demand to achieve exceptionally high formability. Therefore,
the push-through design feature can be achieved after forming, i.e. on the blister line. Laser
ablation/cutting can be used to weaken the layers or scratching/ punching can again be used t o
weaken the laminate in a certain region/area, enabling easy breaking of the laminate when
pushing the tablet through.
[0041] Another advantage of the present invention is the sustainability of the double-shell
blister pack since "thick" laminates lead t o a higher CO2 emission than thin foils and one would
expect a worse CO2 emission balance per square meter for the structures according to the
invention than for the combinations used in a standard single-shell blister as they are thicker
and heavier. Nevertheless, the blister pack according to the invention can pack up to 75 % more
tablets or capsules, as the cavity area size is up to 75 %smaller leading to a better CO2 emission
balance than for prior-art blisters (see Table 2).
[0042] Another aim of the present invention is to considerably reduce the so-called crossdiffusion.
Cross-diffusion is the moisture and gas entering the cavity by diffusion through the
seal layer (see Fig. 1 to 3). Humidity is an important issue in pharmaceutical applications. Table
1 shows calculated cross-diffusions based on the available perimeter of the cavity of a blister
pack conditioned by a double-shell configuration. The single-shell blister bottom foil with same
inner side as the double-shell blister bottom foil and the lid of the prior art is taken as 100 %
reference for the respective example.
[0043] The calculations take into account the water-vapor transmission coefficients
(g/m /day) of the individual layer of the bottom and the lid foil on the inner sides (IS and sealing
side of the Al foil) - see relevant layer for cross-diffusion in Fig. 3. The calculation also takes into
account the thickness of these individual layers and the available perimeter relative t o a singleshell
blister pack with lid (perimeter where humidity may enter the cavity by cross diffusion).
Fig. 5 and Table 2 allow the calculation of the perimeter that represents about 55 % of the
perimeter of a single-shell cavity.
[0044] The double-shell example B (PA25/PA25/AI/PE) achieves a cross-diffusion
reduction of 27 %compared t o the single-cavity blister example B of the prior art. Important is
the reduction in perimeter, where the cross-diffusion enters the cavity, by reduction of the
blister-cavity size and minimizing the thickness of the seal layer. This is achieved by reducing the
blister-cavity size and subsequently the perimeter through which cross-diffusion occurs by using
an Al laminate with increased multidirectional deformability (approximately 40 %) and by
forming both lid and bottom foil creating a double-shell according to the invention. The cavities
are formed in a blister line forming both lid and bottom foil. A scheme of a blister line for that
purpose is shown in Fig. 9.
[0045] The most important difference to a usual blister line is the second forming station
for the lid and the possible presence of a second sealing station to heat the multilayer structure
from both sides.
[0046] Further advantages of the present invention are:
- less space in shelf / less volume consumed in the shelves;
- less secondary costs (smaller folding carton, less air transported in truck);
- higher line productivity (more tablets packed per minute);
- smaller in the pocket of a patient.
[0047] The extremely low cross-diffusion rate of this type of packaging is evaluated at
approximately 1.4* 10 6 g water-vapor/day. On the contrary, the best thermoform blister
typically has a cross-diffusion rate of approximately. 1* 10 4 g water/day entering the cavity
under 40 °C/75 % relative humidity outside of the blister and 40 °C/0 % rh. inside, wherein the
blister tablet is considered as an infinite water absorption sink.
[0048] This low quantity of water-vapor diffusion is difficult t o measure and it can only be
performed by using several blisters having several cavities over long periods of time (half a year
for example, 10 blisters with 10 cavities). Then, a difference of 0.1 mg can be measured.
Examples: 1.4* 10-6* 10 blisters* 10 cavities*183 days (half year) = 0,026 g in half a year. And
1.83 g for the thermoform case, which corresponds to half a year at 40/75, is a typical storage
condition for pharmaceutical companies (so called ICH conditions).
[0049] For the aluminium layer, soft temper types are used as multidirectional
stretchability is required. Non-limitative exemples are: EN AW 8006, EN AW 8021, EN AW 8021A,
EN AW 8021B, EN AW 8014.
[0050] The above-mentioned Al alloys can be milled, and after soft tempering, their
elongation at break is above 8 %and tensile strength is above 60 MPa. The surface of the Al foil
must be homogeneous and free of oil. Optionally, the surface of the aluminium foil can be
surface treated (corona, plasma, chemically, primer, washed with solvent MEK). The alloy should
be fine grained with small and uniform grain sizes, there should be more than five, preferably
seven, grain layers above each other across the thickness.
[0051] The so-called support layers are specific plastic layers which, due t o their intrinsic
stiffness or thickness, reach a tensile strength at break above 200 N/mm 2 in machine and
transversal direction, and an elongation/strain at break above 50 % in machine and transversal
direction. Furthermore, the strain hardening should have a substantially positive slope in the
corresponding technical stress/strain curves. The determination of the tensile strength and
elongation at break as well as technical stress/strain curves is performed by a (Zwick/lnstron)
tensile testing machine according t o EN ISO 527-3 1995, sample type 2, part 1-6.
Examples
[0052] The following tables show examples of typical structures according t o the invention
for top and bottom of peelable double-shell blisters (examples 1 to 6) and tear-open blisters
(examples 7 t o 12). The commercial types of the polyurethane adhesives, primer, and
coextruded tie layer as well as the support layer and the seal layers are specified below.
- PP MAH is Orevac ® 18750 from Arkema (MAH = maleic acid anhydride grafted polypropylene)
- PE MAH is Plexar® 3243 from Equistar (MAH grafted LLDPE, linear low density polyethylene)
- PI (polyimide) is Kapton ® from DuPont™
- oPPS (oriented polyphenylenesulfid) is Torelina ® 3030 from Toray
- Aramid is Mictron ® from Toray; aramid is aromatic polyamide
- PVC is Perlalux mono 60H from Perlen Packaging; PVC is polyvinylchloride
- Coex film Rayopeel P med ® from Amcor Flexibles Gent-Extrusion with LDPE, LLDPE and PB-1
as peelable component used for medical applications
- oPA is Honeywell Capran ® Emblem(TM) 2500 (bi-axially oriented film of nylon 6)
- oPET is Mylar ® 813 from Du Pont (bi-axially oriented film of polyethyleneterephtalate)
- PETG film is Amcor Flexibles Gent-Extrusion Rayopet G® film, based on Eastar 6763 from
Eastman
- Peelable PETG film from Amcor Flexibles Gent-Extrusion according to EP2540492
- Cast coextruded PP film with a Borealis C2,C4 PP ter-polymer TD215BF (Ml = 6 and melt
temperature = 130 °C) sealant layer and a Borealis homo PP HD214C melt index = 8 and melt
temperature = 162°C) layer, with a layer ratio ter-polymer/homo polymer (1/2)
- Blown coextruded PE film with a Dex Plastomers C8-based mVLDPE Exact0201FX (density
0.902, melt index = 1.1 and melt temperature = 96 °C) sealant layer and an Exxon Mobil C4-
based LLDPE 1001XV (density 0.918, melt index = 1.0 and melt temperatures at 111 °C and
122 °C) layer, with a layer ratio (1/3)
- Peelable seal lacquer is composed of 5 % Dow Ucar™ VMCH, 25 % Degalan N80 from Evonik
and 70 % solvent methylethylketone (MEK)
- Tight seal lacquer is 7% Dow Ucar™ VMCH, 18 % Evonik Degalan P24 and 75 % M EK
- PU adhesive is Henkel Liofol® 6800 1,5 %, Henkel Liofol® 3640 75 %and 23.5 %solvent ethylacetate
- PU Primer is Luphen ® 700, a water-based polyester PU elastomer dispersion from BASF
(The lacquers, primers and adhesives are applied with roller coating, solvent is evaporated in a
drying oven) .The lamination step of the examples is achieved by extrusion lamination or
solvent-based adhesive lamination.
The layer thickness and weight of the various examples is reported in the following tables

Table 1
* relative t o the single-shell cavity referenced at 100 %
IS: inside seal
HSL: heat-seal lacquer
Table 2
Size comparison calculation of single-shell blister with lid and double-shell blister according to the invention
Capsule 00 (23.3 mm length and 8.5 mm diameter)
1 Forming depth

CLAIMS
1. Double-shell blister packaging (1) for medicinal contents (5) comprising one
or more cavity(ies), wherein the ratio of the volume of the cavity(ies) to the volume of the
medicinal content (5) is comprised between 1.8 and 1, preferably between 1.6 and 1.1, and most
preferably between 1.5 and 1.2, said double-shell packaging being the assembly of a first and of
a second multilayer structures sealed to each other via one or more seal layer(s) (3), each
multilayer structure comprising one or more aluminum layer(s) (4) with a thickness of at least
20 miti, preferably 30 miti, and two or more support layers (2), wherein said two or more support
layers (2) have a tensile strength at break measured in machine and transversal direction of
200 N/mm 2 or more, and an elongation at break of 50 % or more, preferably 70 % or more,
measured according to EN ISO 527-3 published in 1995, sample type 2, part 1-6, each of said
multilayer structures comprising cavities which, arranged face t o face, enclose in use said
medicinal content (5).
2. Blister packaging (1) according to Claim 1, wherein said one or more
aluminium layer(s) (5) is/are sandwiched between the two or more support layers (2).
3. Blister packaging (1) according to any of the preceding claims, wherein the
stress/strain curves measured on said support layer (2) present a positive slope for the
measurement of the strain hardening according t o EN ISO 527-3 published in 1995, sample type
2, part 1-6.
4. Blister packaging (1) according to any of the preceding claims, wherein the
thickness of the one or more aluminium layer(s) (4) within the one or more cavity(ies), due t o
the stretch cold forming process, represents at least 30 % of the thickness of the one or more
aluminium layer(s) (4) in the multilayer structure in the periphery of said cavities.
5. Blister packaging (1) according t o any of the preceding claims, wherein said
blister is of a tearable, push-trough or a peelable type comprising one or more seal layer(s) (3)
selected from the group consisting of heat-seal lacquer with a thickness of 15 miti or less,
preferably 10 miti or less, a seal-initiation temperature determined by welding trials of 125 °C or
less, preferably 110 °C or less, and a melting temperature determined by differential scanning
calorimetry of 125 °C or less, preferably 120 °C or less, and most preferably of 115 °C or less,
measured under a heating speed of 20 °C/min between 50 and 150 °C and represented by the
peak maximum of the second run.
6. Blister packaging (1) according t o any of the preceding claims, wherein said
blister is of a tearable, push-trough or a peela ble type comprising one or more seal layer(s) (3)
comprising coextruded polymer films and extrusion coatings with a thickness of 50 miti or less,
preferably 35 miti or less, a seal-initiation temperature determined by welding trials of 135 °C or
less, preferably 120 °C or less, and a melting temperature determined by differential scanning
calorimetry of 135 °C or less, preferably 125 °C or less, and most preferably of 115 °C or less,
measured under a heating speed of 20 °C/min between 50 and 150 °C and represented by the
peak maximum of the second run.
7. Blister packaging (1) according to any of the preceding claims, wherein the
seal layer (3) for the peelable blister has a peel strength comprised between 1.2 and 10 N/15mm.
8. Blister packaging according to any of the preceding claims, wherein said
peelable seal layer comprises LLDPE, poly-l-butene and inorganic filler material.
9. Blister packaging (1) according to any of the preceding claims, wherein the
seal layer (3) for the tearable or push-through blister type is selected from the group consisting
of a linear low-density polyethylene of a density between 0.902 and 0.925 g/cm , partially or
entirely neutralized ionomer, EMA, EBA, polyethylene obtained by metallocene catalysis,
ethylene vinyl acetate, polyethyleneterephtalate glycol.
10. Blister packaging (1) according t o any of the preceding claims, wherein said
peelable seal layer (3) for the peelable blister type comprises compositions selected from the
group consisting of polyolefin blends and/or copolymers of modified ethylene acrylate, blends
of linear low density polyethylene or polyethylene obtained by metallocene catalysis and
polybutylene.
11. Blister packaging (1) according t o any of the preceding claims, wherein said
peelable seal layer (3) for the peelable blister comprises lacquer compositions selected from the
group consisting of phenoxy resins, blends of copolymers of methacrylic ester, olefins and
ethylidennorbornen as binder, blends of polybutylmetacrylate, polybutylethacrylate and acrylic
resins as binder, tackifier based on alphamethylstyrene, maleic acid anhydride modified
copolymers of vinylacetate and vinylchloride and water-based dispersions based on
ethylenevinylacetate, ethylene acrylic acid and metacrylic acid and salts thereof.
12. Blister packaging (1) according t o any of the preceding claims, wherein said
multilayer structures additionally comprise two or more adhesive or tie layers selected from the
group consisting of EAA, ionomers, EMA and EBA.
13. Blister packaging (1) according to any of the preceding claims, said packaging
comprising weakening lines or tear notches in the polymer layer(s) on the top and/or on the
bottom of said first and/or second multilayer structure(s), the weakening lines preserving the
barrier effect of the aluminium layer.
14. Process for the manufacturing of the blister packaging according to any of
the preceding claims, comprising the following steps:
- supplying a first and second multilayer structures comprising one or more aluminium layer(s)
(4) with a thickness of at least 20 miti, preferably 30 miti, and two or more support layers (2)
having a tensile strength at break measured in machine and transversal direction of
200 N/mm 2 or more, and an elongation at break of 50 %or more, preferably 70 %or more,
measured according to EN ISO 527-3 published in 1995, sample type 2, part 1-6, said
multilayer structures having a multidirectional deformability of 35 %or more;
- stretch-cold forming of said first and second multilayers to form one or more cavity(ies);
- filling said one or more cavity(ies) of one of the first or second multilayer structure with the
medicinal content (5);
- sealing the first and second multilayer structures face t o face;
- cutting the sealed multilayer into blister packaging units (1);
- conditioning in over-pack boxes or bags.
15. Process according t o Claim 14, comprising an additional step of cutting a
weakening line or a tear notch into the first and/or second multilayer structure(s) t o allow a
push-through opening or a tear opening of said blister packaging.
16. Process according t o Claim 15, wherein the cutting of a weakening line or a
tear notch is performed by laser cutting through the polymer layer(s) on the top and/or the
bottom of the first and/or second multilayer structure(s), the laser beam being stopped by the
aluminium layer to keep a total gas barrier.