WE CLAIM:
[Claim 1]
A guanidine derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof: [Formula 1]

wherein
R1 to R6 each independently represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, a cyano group, a methoxycarbonyl group or a hydroxy group, wherein
in each of the alkyl group having 1 to 3 carbon atoms and the alkoxy group having 1 to 3 carbon atoms, 1 to 5 hydrogen atoms are optionally replaced, each independently, with a halogen atom;
X and Y each independently represent N or CH, and Z represents N or CR7, with the proviso that X, Y and Z neither represent N at the same time nor represent the group other than N at the same time;
R7 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms or a hydroxy group;
R8 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms;
A represents S(=0)2, C(=0) or CH2;
R9 represents an alkoxy group having 1 to 3 carbon atoms; an amino group; a dimethylamino group; an alkyl group having 1 to 6 carbon atoms in which 1 to 3 hydrogen atoms are optionally replaced, each independently, with a halogen atom, a

methoxy group or a phenyl group; a cycloalkyl group having 3 to 6 carbon atoms in which 1 to 3 hydrogen atoms are optionally replaced, each independently, with a halogen atom; an aryl group in which 1 or 2 hydrogen atoms are optionally replaced, each independently, with a halogen atom, a trifluoromethyl group, an alkoxy group having 1 to 3 carbon atoms, a hydroxy group or a cyano group; or a heteroaryl group in which one hydrogen atom is optionally replaced with a halogen atom, a methyl group or a cyano group; and
R10 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a hydroxy group or an amino group. [Claim 2]
The guanidine derivative or the pharmacologically acceptable salt thereof according to claim 1, wherein
R1 and R4 are each independently a hydrogen atom, a fluorine atom, a chlorine atom, a methyl group, a trifluoromethyl group, a methoxy group, an isopropoxy group, a trifluoromethoxy group or a cyano group;
R2, R3, R5 and R6 are each independently a hydrogen atom, a fluorine atom or a chlorine atom;
the combination of X to Z is X = CH, Y = N, and Z = CR7, X = CH, Y = CH, and Z = N, X = N, Y = CH, and Z = CH, or X = N, Y = CH, and Z = N;
R7 is a hydrogen atom, a fluorine atom, a methyl group, a methoxy group or a hydroxy group;
R8 is a hydrogen atom or a methyl group;
A is S(=0)2;
R9 is a dimethylamino group; a benzyl group; a cycloalkyl group having 3 to 6 carbon atoms; a phenyl group in which one hydrogen atom is optionally replaced with a halogen atom, an alkoxy group having 1 to 3 carbon atoms, a hydroxy group or a cyano group; or a heteroaryl group in which one hydrogen atom is optionally replaced with a halogen atom, a methyl group or a cyano group; and
R10 is a hydrogen atom, a methyl group, a hydroxy group or an amino group.

[Claim 3]
The guanidine derivative or the pharmacologically acceptable salt thereof according to claim 1, wherein
R1 and R4 are each independently a hydrogen atom, a fluorine atom, a chlorine atom, a methyl group, a trifluoromethyl group, a methoxy group, a trifluoromethoxy group or a cyano group;
each of R2, R3, R5 and R6 is a hydrogen atom;
the combination of X to Z is X = CH, Y = N, and Z = CR7, X = CH, Y = CH, and Z = N, X = N, Y = CH, and Z = CH, or X = N, Y = CH, and Z = N;
R7 is a hydrogen atom, a fluorine atom, a methyl group, a methoxy group or a hydroxy group;
R8 is a hydrogen atom;
A is S(=0)2;
R9 is a dimethylamino group; a cycloalkyl group having 3 to 6 carbon atoms; a 2-thienyl group; a 5-chloro-2-thienyl group; a 3-thienyl group; a 2-furyl group; a 3-furyl group; a 2-benzothienyl group; or a phenyl group in which one hydrogen atom is optionally replaced with a halogen atom, an alkoxy group having 1 to 3 carbon atoms, a hydroxy group or a cyano group; and
R10 is a hydrogen atom, a methyl group, a hydroxy group or an amino group. [Claim 4]
The guanidine derivative or the pharmacologically acceptable salt thereof according to claim 1, wherein
each of R1 and R4 is a chlorine atom;
each of R2, R3, R5 and R6 is a hydrogen atom;
the combination of X to Z is X = CH, Y = N, and Z = CR7, X = CH, Y = CH, and Z = N, X = N, Y = CH, and Z = CH, or X = N, Y = CH, and Z = N;
R7 is a hydrogen atom, a fluorine atom, a methyl group, a methoxy group or a hydroxy group;
R8 is a hydrogen atom;

A is S(=0)2;
R9 is a dimethylamino group; a cycloalkyl group having 3 to 6 carbon atoms; a 2-thienyl group; a 5-chloro-2-thienyl group; a 3-thienyl group; a 2-furyl group; a 3-furyl group; a 2-benzothienyl group; or a phenyl group in which one hydrogen atom is optionally replaced with a halogen atom, an alkoxy group having 1 to 3 carbon atoms, a hydroxy group or a cyano group; and
R10 is a hydrogen atom, a methyl group, a hydroxy group or an amino group. [Claim 5]
The guanidine derivative or the pharmacologically acceptable salt thereof according to claim 1, wherein
R1 and R4 are each independently a hydrogen atom, a fluorine atom, a chlorine atom, a methyl group, a trifluoromethyl group, a methoxy group, a trifluoromethoxy group or a cyano group;
each of R2, R3, R5 and R6 is a hydrogen atom;
XisCH;
YisN;
Z is CR7;
R7 is a hydrogen atom or a fluorine atom;
R8 is a hydrogen atom;
A is S(=0)2;
R9 is a dimethylamino group; a cycloalkyl group having 3 to 6 carbon atoms; a 2-thienyl group; a 5-chloro-2-thienyl group; a 3-thienyl group; a 2-furyl group; a 3-furyl group; a 2-benzothienyl group; or a phenyl group in which one hydrogen atom is optionally replaced with a halogen atom, a methoxy group, an ethoxy group, a hydroxy group or a cyano group; and
R10 is a hydrogen atom. [Claim 6]
The guanidine derivative or the pharmacologically acceptable salt thereof according to claim 1, wherein

R1 and R4 are each independently a hydrogen atom, a fluorine atom, a chlorine atom, a methyl group, a trifluoromethyl group, a methoxy group, a trifluoromethoxy group or a cyano group;
each of R2, R3, R5 and R6 is a hydrogen atom;
the combination of X to Z is X = CH, Y = N, and Z = CR7, or X = CH, Y = CH, andZ=N;
R7 is a hydrogen atom;
R8 is a hydrogen atom;
A is C(=0);
R9 is an ethoxy group; an amino group; a dimethylamino group; a 2-thiazolyl group; a 4-thiazolyl group; a 2-thienyl group; a 3-thienyl group; a 2-pyridyl group; a 2-furyl group; an alkyl group having 2 to 5 carbon atoms in which 1 to 3 hydrogen atoms are optionally replaced, each independently, with a fluorine atom, a methoxy group or a phenyl group; a cycloalkyl group having 3 to 6 carbon atoms in which 1 or 2 hydrogen atoms are optionally replaced with fluorine atom(s); or a phenyl group in which one hydrogen atom is optionally replaced with a fluorine atom, a chlorine atom, a trifluoromethyl group, a methoxy group or a cyano group; and
R10 is a hydrogen atom. [Claim 7]
The guanidine derivative or the pharmacologically acceptable salt thereof according to claim 1, wherein
each of R1 and R4 is a chlorine atom;
each of R2, R3, R5 and R6 is a hydrogen atom;
the combination of X to Z is X = CH, Y = N, and Z = CR7, or X = CH, Y = CH, andZ=N;
R7 is a hydrogen atom;
R8 is a hydrogen atom;
A is C(=0);

R9 is an ethoxy group; an amino group; a dimethylamino group; a 2-thiazolyl group; a 4-thiazolyl group; a 2-thienyl group; a 3-thienyl group; a 2-pyridyl group; a 2-furyl group; an alkyl group having 2 to 5 carbon atoms in which 1 to 3 hydrogen atoms are optionally replaced, each independently, with a fluorine atom, a methoxy group or a phenyl group; a cycloalkyl group having 3 to 6 carbon atoms in which 1 or 2 hydrogen atoms are optionally replaced with fluorine atom(s); or a phenyl group in which one hydrogen atom is optionally replaced with a fluorine atom, a chlorine atom, a trifluoromethyl group, a methoxy group or a cyano group; and
R10 is a hydrogen atom. [Claim 8]
A medicament comprising the guanidine derivative or the pharmacologically acceptable salt thereof according to any one of claims 1 to 7 as an active ingredient. [Claim 9]
A mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibitor comprising the guanidine derivative or the pharmacologically acceptable salt thereof according to any one of claims 1 to 7 as an active ingredient. [Claim 10]
A therapeutic or prophylactic agent for autoimmune disease comprising the guanidine derivative or the pharmacologically acceptable salt thereof according to any one of claims 1 to 7 as an active ingredient. [Claim 11]
A therapeutic or prophylactic agent for psoriasis comprising the guanidine derivative or the pharmacologically acceptable salt thereof according to any one of claims 1 to 7 as an active ingredient. [Claim 12]
A therapeutic or prophylactic agent for allergic disease comprising the guanidine derivative or the pharmacologically acceptable salt thereof according to any one of claims 1 to 7 as an active ingredient. [Claim 13]

A therapeutic or prophylactic agent for atopic dermatitis comprising the guanidine derivative or the pharmacologically acceptable salt thereof according to any one of claims 1 to 7 as an active ingredient.