Description:HERBICIDAL COMPOSITION

FIELD OF THE INVENTION
The present invention relates to a stable, synergistic herbicidal composition and a process for preparation thereof. Further, the present invention also relates to a method for combating narrow-leaved weeds, broad-leaved weeds and sedges in agricultural crops, particularly in wheat.

BACKGROUND OF THE INVENTION
Weed control is an important practice for crops growth. The losses caused by weeds in agricultural production environments include reduced crop quality, increased irrigation costs, increased harvesting costs, reduced land value, injury to livestock and crop damage from insects and pests harbored by the weeds. Further, weeds may compete with crop plants for the essential nutrients and may produce toxic or irritant chemicals that cause human or animal health problems. Some of the weed varieties also produce immense quantities of seed or vegetative reproductive parts or both that contaminate agricultural products and perpetuate the species in agricultural land.

The main issue with using herbicides is the emergence of pest resistance to that specific herbicide, necessitating the use of a more concentrated herbicidal formulation. A higher concentration of herbicide may be hazardous to human beings and have negative effects on the environment. In the past, people have explored a variety of alternatives and options to solve this issue, leading to the development of poly herbicides mixtures, the use of non-toxic chemicals, and the development of innovative formulations that deliver an effective amount of the herbicide just where it is needed. However, using a poly combination with a lot of herbicides can be problematic because it is akin to mixing up a bunch of herbicides with distinct chemical, behavioral, and physical characteristics. Additionally, it presents difficulties for the formulator in terms of the stability and compatibility of each herbicide as well as the excipients utilized in the formulation.

Clodinafop-propargyl is a commonly used herbicide. Clodinafop-propargyl is chemically known as prop-2-ynyl (2R)-2-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenoxy]propanoate, having a chemical structure as below:

Clodinafop-propargyl is a selective systemic post emergence herbicide, used for the control of grassy weeds in cereals, mainly wheat. It belongs to aryloxyphenoxy propionate class of herbicides. Clodinafop-propargyl may act as a peroxisomal proliferating agent and alters monooxygenase activity in subfamilies of cytochrome P450 which are known to be involved in the synthesis or catabolism of steroid hormones.

Metribuzin is a synthetic organic compound and a widely used herbicide applied in preemergence and postemergence on intensive vegetable crops. Metribuzin is chemically known as 4-amino-6-tert-butyl-3-methylsulfanyl-1, 2, 4-triazin-5-one, having a chemical structure as below:

It is known for its efficiency and relatively low toxicity. Metribuzin is slightly soluble in water, and slightly soluble in several organic solvents. Metribuzin belongs to Triazinone class of herbicide. The mode of action of Metribuzin is that it acts by inhibiting photosystem II of photosynthesis by disrupting electron transfer. This results in death due to starvation in the target plant.

Metsulfuron-methyl is an organic compound classified as a sulfonylurea herbicide, which kills broadleaf weeds and some annual grasses. Metsulfuron-methyl is chemically known as methyl 2-[(4-methoxy-6-methyl-1, 3, 5-triazin-2-yl)carbamoyl sulfamoyl] benzoate, having a chemical structure as below:

Metsulfuron methyl is a selective herbicide, meaning that it can control target broadleaf weeds, grasses, trees and invasive bush, while doing no harm to select desired grasses. It is a systemic compound with foliar and soil activity that inhibits cell division in shoots and roots. Metsulfuron methyl acts by inhibiting cell division in the shoots and roots of the plant, and it is biologically active at low use rates.

The protection of crops from weeds and other vegetation which inhibit crop growth is a constantly recurring problem in agriculture. To help combat this problem, researchers in the field of synthetic chemistry have produced an extensive variety of chemicals and chemical formulations effective in the control of such unwanted growth. Chemical herbicides of many types have been disclosed in the literature and a large number are in commercial use. However, there remains a need for compositions and methods that are effective in controlling undesirable vegetation.

There is therefore a continuing need to a find new compositions having superior biological properties for use in controlling or preventing infestation of plants; for example, compounds possessing a greater herbicidal efficacy, an advantageous spectrum of activity, an increased safety profile, improved physio-chemical properties, or compositions possessing a broad spectrum of activity, improved crop tolerance, synergistic interactions or potentiating properties, or compositions which display a more rapid onset of action or which have long lasting residual activity or which enable a reduction in the number of applications and/or a reduction in the application rate of the compounds and compositions required for effective control of a phytopathogen, thereby enabling beneficial resistance-management practices, reduced environmental impact and reduced operator exposure.

Surprisingly, the inventors of the present invention have found that the novel and synergistic composition of Clodinafop-propargyl, Metribuzin, Metsulfuron methyl and vegetable oil, as described herein, provides a solution to the above-mentioned problems.

OBJECT(S) OF THE INVENTION
It is an object of the present invention to provide a novel, synergistic herbicidal composition for controlling weeds in various agricultural crops.

It is another object of the present invention to provide an herbicidal composition comprising Clodinafop- propargyl, Metribuzin, Metsulfuron methyl and vegetable oil.

It is yet another object of the present invention to provide an herbicidal composition having enhanced efficacy in comparison to the solo application of individual actives.

It is yet another object of the present invention to provide an herbicidal composition for enhancing crop yield without having any phytotoxicity.

It is yet another object of the present invention to provide a process for preparing the synergistic herbicidal composition.

It is yet another object of the present invention to provide a method for combating weeds in various agricultural crops without causing any phytotoxicity.

SUMMARY OF THE INVENTION
In one aspect, the present invention provides a novel, stable, synergistic, environmentally safe, herbicidal composition comprising:
a. Clodinafop- propargyl in an amount ranging from 4-20% w/w;
b. Metribuzin in an amount ranging from 10-30% w/w;
c. Metsulfuron methyl in an amount ranging from 0.1-25% w/w;
d. at least one safener in an amount ranging from 1-10% w/w;
e. at least one vegetable oil in an amount ranging from 0.1-5% w/w; and
f. at least one agriculturally acceptable excipient.

In another aspect, the present invention provides a process for the preparation of an herbicidal composition, comprising:
a. obtaining a homogeneous mixture of at least one wetting cum dispersing agent, wetting agent, emulsifier and filler;
b. adding Clodinafop- propargyl technical, Metribuzin technical., Metsulfuron methyl technical and Cloquintocet Mexyl to the homogenous mixture of step (a);
c. mixing the mixture of step (b) in a blender;
d. grinding the mixture of step (c) in a jet mill to obtain a particle having size less than 10 microns;
e. blending the mass obtained in step (d) (Post blending mix) to obtain a homogenous mass;
f. transferring the blended material obtained in step (e) into a post blender;
g. adding vegetable oil to the mixture obtained in step (f) and mix well to get a uniform powder.

In yet another aspect, the present invention provides a method for combating weeds in various agricultural crops without substantial harm to the crops, which comprises treating the plants, or cuttings thereof or the locus of the useful plants with an herbicidal composition comprising a) herbicidally active amount of the Clodinafop-propargyl; b) an herbicidally active amount of Metribuzin; c) an herbicidally active amount of Metsulfuron methyl and vegetable oil along with at least one agriculturally acceptable excipient.

TECHNICAL ADVANCEMENTS OF THE INVENTION
The herbicidal composition as disclosed in the present invention comprises Clodinafop- propargyl, Metribuzin, Metsulfuron methyl and vegetable oil as described herein above and has several associated technical advantages including but not limited to:
? enhanced weeds control;
? synergistic action;
? broad spectrum of weed management;
? reduced active dosage;
? plant health benefits; and
? reduced environmental impact.

DETAILED DESCRIPTION OF THE INVENTION
Abbreviations
D.M. Demineralized Water
RTU Ready to Use
WG Wettable granules
A.I/a.i Active Ingredients
WC No. of weeds in control plot
WT No. of weeds in treated plot
DAA Days After Application
QS Quantum satis

Those skilled in the art will be aware that the invention described herein is subject to variations and modifications other than those specifically described herein. It is to be understood that the invention described herein includes all such variations and modifications. The invention also includes all such steps, features, compositions and compounds referred to or indicated in this specification, individually or collectively, and all combinations of any two or more of said steps or features.

Unless otherwise specified, all terms used in disclosing the invention, including technical and scientific terms, have the meaning as commonly understood by one of the ordinary skills in the art to which the invention belongs. For further guidance, term definitions may be included to better appreciate the teaching of the present invention.

The terminology used, in the present invention, is only for the purpose of explaining a particular embodiment and such terminology shall not be considered to limit the scope of the present invention. As used in the present disclosure, the forms "a,” “an” and “the” may be intended to include the plural forms as well, unless the context clearly suggests otherwise. The terms “comprises” “comprising” “including,” and “having,” are open ended transitional phrases and therefore specify the presence of stated features, integers, steps, operations, elements, modules, units and/or components, but do not forbid the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.

The particular sequence of steps disclosed in the method and process of the present invention is not to be construed as necessarily requiring their performance as described or illustrated. It is also to be understood that additional or alternative steps may be taken.

As used herein, the term “and/or” includes any and all combinations of one or more of the associated listed elements.

As used herein, the term “plant” refers to any plant or part thereof including serial and subterranean parts of the plant. It is contemplated that the parts of the plant may be for example, flowers, fruits or vegetables, shoots, leaves, needles, stalks, stems, fruiting bodies, seeds also roots and that parts of the plants may or may not be attached to the remainder of the plant.

As used herein, the term “weed” refers to the unwanted plant which competes for resources with the crop or plant of interest.

As used herein, the term “herbicide” refers to a substance which adversely affects the existence and growth of the target weed.

As used herein the term “herbicidally effective amount” is that quantity of the herbicide active ingredient, applied in an amount which will provide the required control of weed on commercial crops. The amount is dependent upon many factors including, for example, type of formulations, the crop, weed sought to be controlled and environmental conditions.

As used herein, the term “weight percent”, “wt-%”, “percent by weight”, “% by weight” and variations thereof, refer to the concentration of a substance as the weight of that substance divided by the total weight of the composition and multiplied by 100. It is understood that, as used here, “percent”, “%” and the like are intended to be synonymous with “weight percent”, “wt. %”, etc.

As used herein, the term “agriculturally acceptable excipient” refers to an ingredient, additive, component or supplement, liquid or solid, suitable for incorporation in agricultural compositions.

The details of biological material used in the present invention:

Using vegetable oil in the present herbicidal compositions offered several advantages.

Some of these advantages include:
? Vegetable oils are biodegradable which reduces the accumulation of harmful chemicals in soil and water bodies, promoting environmental health.
? Vegetable oils have low toxicity levels compared to synthetic chemicals commonly used in herbicides, reducing the risk of harm to non-target organisms.
? Vegetable oil-based herbicides offer selective weed control, targeting specific types of weeds while sparing desired crops or vegetation.
? Vegetable oils enhance the adhesion and penetration of herbicidal compounds onto plant surfaces, which improves the efficacy of the herbicide, leading to more effective weed control.
? Vegetable oils may enhance the performance of herbicidal compounds through synergistic effects.
? Vegetable oil-based herbicides can reduce runoff compared to water-soluble herbicides, preventing the contamination of nearby water sources with herbicidal chemicals, preserving aquatic ecosystems and water quality.

These benefits make vegetable oil-based herbicides a promising option for sustainable weed management in agriculture.

The vegetable oil was procured from 4825 Jalan Permatang Pauh, 13400 Butterworth, P.W. Malaysia.

In one aspect, the present invention provides a novel, stable, synergistic, environmentally safe, herbicidal composition comprising a) Clodinafop- propargyl in an amount ranging from 4-20% w/w; b) Metribuzin in an amount ranging from 10-30% w/w; c) Metsulfuron-methyl in an amount ranging from 0.1-25% w/w; d) at least one safener in an amount ranging from 1-10% w/w; e) at least one vegetable oil present in amount ranging from 0.1-5% w/w and f) at least one agriculturally acceptable excipient.

In an embodiment of the present invention, Clodinafop- propargyl is present in an amount ranging from 4-20% w/w.

In a preferred embodiment of the present invention, Clodinafop- propargyl is present in an amount of 10% w/w.

In an embodiment of the present invention, Metribuzin is present in an amount ranging from 10-30% w/w.
In a preferred embodiment of the present invention, Metribuzin is present in an amount of 17% w/w.

In an embodiment of the present invention, Metsulfuron- methyl is present in an amount ranging from 0.1-25% w/w.

In a preferred embodiment of the present invention, Metsulfuron methyl is present in amount of 0.53% w/w.

In an embodiment of the present invention, said safener is selected from mefenpyr-diethyl, isoxadifen-ethyl, cloquintocet-mexyl, dichlormid, benoxacor, fenclorim, flurazole, fluxofenim, and combinations thereof.

In a preferred embodiment of the present invention, said safener is cloquintocet-mexyl.
In an embodiment of the present invention, said safener is present in an amount ranging from 1-10% w/w.

In a preferred embodiment of the present invention, said safener is present in an amount of 2.5% w/w.

In an embodiment of the present invention, said vegetable oil is selected from the group consisting of olive oil, sunflower oil, canola oil, coconut oil, safflower oil, corn oil, peanut oil, cottonseed oil, palm-kernel oil, and soybean oil.

In an embodiment of the present invention, said vegetable oil is present in an amount ranging from 0.1-5% w/w.

In a preferred embodiment of the present invention, said vegetable oil is present in an amount of 1% w/w.

In an embodiment of the present invention, said agriculturally acceptable excipient is selected from the group consisting of at least one anti-freeze agent, at least one dispersing agent, at least one wetting agent, at least one deformer, at least one anti-bacterial or biocide, at least one thickener, and a combination thereof.
In a preferred embodiment of the present invention, said agriculturally acceptable excipient comprises a combination of at least a wetting cum dispersing agent, wetting agent, emulsifier and filler.

In an embodiment of the present invention, said at least one wetting cum dispersing agent is selected from the group consisting of alkyl phenol Ethoxylate, salts of alkyl naphthyl sulphonate, salts of alkyl aryl sulphonate, derivative of sulfonated fatty alcohol, anionic sulphonate, blend of aromatic sulphonic acid sodium salt, Blend of alkyl aryl sulphonic acid sodium salt and combination thereof.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is anionic sulphonate.

In an embodiment of the present invention, said wetting cum dispersing agent is present in an amount ranging from 0.5-5% w/w.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is present in an amount of 3% w/w.

In an embodiment of the present invention, said at least one wetting agent is selected from the group of consisting of blend of alkyl naphthalene sulfonate, sodium salt, amine salt of poly aryl phenyl ether phosphate, Sodium laurel sulphate, poly alkyl aryl ethylene oxide phosphate ester, taurates and combination thereof.

In a preferred embodiment of the present invention, said wetting agent is taurates.

In an embodiment of the present invention, said wetting agent is present in an amount ranging from 0.5-3% w/w.

In a preferred embodiment of the present invention, said wetting agent is present in an amount of 1.50% w/w.

In an embodiment of the present invention, said at least one emulsifier is selected from the group consisting of polyoxyethylenealkyl ether, glycerol monostearate, fatty alcohol alkoxylates and oxoalcohol alkoxylates,sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, alkylpolyglycosides, N-alkylgluconamides, alkylmethyl sulfoxides, alkyldimethylphosphine, fatty Alcohol Alkoxylate and combination thereof.

In a preferred embodiment of the present invention, said emulsifier is fatty Alcohol Alkoxylate.
In an embodiment of the present invention, said emulsifier is present in an amount ranging from 10-40.0% w/w.

In a preferred embodiment of the present invention, said emulsifier is present in an amount of 25% w/w.

In an embodiment of the present invention, said at least one filler is selected from the group consisting of silicone emulsions, precipitate silica, long-chain alcohols, fatty acids, organic fluorine compounds and combinations thereof.

In a preferred embodiment of the present invention, said filler is precipitate silica.

In an embodiment of the present invention, said filler present in an amount ranging from 15.0-65.0% w/w.

In a preferred embodiment of the present invention, said filler is present in amount of 40.47% w/w.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is present in an amount of 3% w/w, wetting agent is present in an amount of 1.50% w/w, emulsifier is present in an amount of 25% w/w, and filler is present in an amount of 40.47% w/w.

In a preferred embodiment, said herbicidal composition comprises:
a. Clodinafop - propargyl is present in an amount of 10% w/w;
b. Metribuzin is present in an amount of 17% w/w;
c. Metsulfuron methyl is an amount of 0.53% w/w;
d. at least one safener is present in an amount of 2.50% w/w;
e. at least one vegetable oil is present in an amount of 1% w/w; and
f. at least one agriculturally acceptable excipient.

In an embodiment of the present invention, said herbicidal composition is formulated in a form selected from the group comprising water-soluble concentrates (SL), emulsifiable concentrates (EC), emulsions (EW), micro-emulsions (ME), Suspension concentrates (SC), oil-based suspension concentrates (OD), flowable suspensions (FS), wettable granules (WG), water-soluble granules (SG), wettable powders (WP), water-dispersible granule (WDG). water soluble powders (SP), granules (GR), encapsulated granules (CG), fine granules (FG), macrogranules (GG), dry flowables (DF), aqueous suspo-emulsions (SE), capsule suspensions (CS) and microgranules (MG).

In a preferred embodiment of the present invention, said herbicidal composition is in the form of wettable granule (WG).

Wettable granule (WG) formulation has following advantages over other types of formulations:
? Wettable granules are easier to handle, and store compared to some other solid formulations like dusts because they are less prone to generating dust during handling.
? Wettable granules, due to their larger particle size, have reduced drift during application compared to dust formulations, ensuring targeted and accurate application, minimizing off-target effects.
? These granules readily disperse in water, forming a stable suspension, which ensures a consistent distribution of the active ingredient.
? These granules provide uniform coverage over the treated area enhancing the efficacy of the agrochemical.
? Wettable granules have additives that enhance their adherence to plant surfaces. This promotes better retention and absorption of the active ingredients, improving efficacy.
? As they are designed for dispersion in water, wettable granules typically have lower environmental impact compared to certain formulations.
? Wettable granules often have good stability, with longer shelf lives compared to some liquid formulations.

The herbicidal composition of the present invention is a Ready to Use Formulation (RTU). The ready to use formulation has various advantages over the tank mix of the active ingredients. These advantages include very few or no inhalation hazards, easy handling, low chances of sedimentation, being environmentally safer, good efficacy without phytotoxicity, lower transportation costs, and scientific practice as the formulation is prepared after stability and compatibility studies.

In another aspect, the present invention provides a process for the preparation of an herbicidal composition, comprising:
a. obtaining a homogeneous mixture of at least one wetting cum dispersing agent, wetting agent, emulsifier and filler;
b. adding Clodinafop- propargyl technical, Metribuzin technical, Metsulfuron methyl technical and Cloquintocet Mexyl to the homogenous mixture of step (a);
c. mixing the mixture of step (b) in a blender,
d. grinding the mixture of step (c) in a jet mill to obtain a particle having size less than 10 microns.
e. blending the mass obtained in step (d) (Post blending mix) to obtain a homogenous mass;
f. transferring the blended material obtained in step (e) into a post blender;
g. adding vegetable oil to the mixture obtained in step (f) and mix well to get a uniform powder.

In an embodiment of the present invention, said at least one wetting cum dispersing agent is selected from the group consisting of alkyl phenol Ethoxylate, salts of alkyl naphthyl sulphonate, anionic sulphonate, salts of alkyl aryl sulphonate, derivative of sulfonated fatty alcohol, blend of aromatic sulphonic acid sodium salt, blend of alkyl aryl sulphonic acid sodium salt and combination thereof.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is anionic sulphonate.

In an embodiment of the present invention, said wetting cum dispersing agent is present in an amount ranging from 0.5-5% w/w.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is present in an amount of 3% w/w.

In an embodiment of the present invention, said at least one wetting agent is selected from the group of consisting of blend of alkyl naphthalene sulfonate, sodium salt, amine salt of poly aryl phenyl ether phosphate, Sodium laurel sulphate, poly alkyl aryl ethylene oxide phosphate ester, taurates and combination thereof.

In a preferred embodiment of the present invention, said wetting agent is taurates.

In an embodiment of the present invention, said wetting agent is present in an amount ranging from 0.5-3% w/w.

In a preferred embodiment of the present invention, said wetting agent is present in an amount of 1.50% w/w.

In an embodiment of the present invention, said at least one emulsifier is selected from the group consisting of polyoxyethylenealkyl ether, glycerol monostearate, fatty alcohol alkoxylates and oxoalcohol alkoxylates,sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, alkylpolyglycosides, N-alkylgluconamides, alkylmethyl sulfoxides, alkyldimethylphosphine, fatty Alcohol Alkoxylate and combination thereof.

In a preferred embodiment of the present invention, said emulsifier is fatty Alcohol Alkoxylate.
In an embodiment of the present invention, said emulsifier is present in an amount ranging from 10-40.0% w/w.

In a preferred embodiment of the present invention, said emulsifier is present in an amount of 25% w/w.

In an embodiment of the present invention, said at least one filler is selected from the group consisting of silicone emulsions, precipitate silica, long-chain alcohols, fatty acids, organic fluorine compounds and combinations thereof.

In a preferred embodiment of the present invention, said filler is precipitate silica.

In an embodiment of the present invention, said filler is present in an amount ranging from 15.0-65.0% w/w.
In a preferred embodiment of the present invention, said filler is present in amount of 40.47% w/w.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is present in an amount of 3% w/w, wetting agent is present in an amount of 1.50% w/w, emulsifier is present in an amount of 25% w/w, and filler is present in an amount of 40.47% w/w.

In an embodiment of the present invention, said safener is selected from mefenpyr-diethyl, isoxadifen-ethyl, cloquintocet-mexyl, dichlormid, benoxacor, fenclorim, flurazole, fluxofenim, and combinations thereof.

In a preferred embodiment of the present invention, said safener is cloquintocet-mexyl.

In an embodiment of the present invention, said safener is present in an amount ranging from 1-10% w/w.

In a preferred embodiment of the present invention, said safener is present in an amount of 2.50% w/w.

In an embodiment of the present invention, Clodinafop- propargyl is present in an amount ranging from 4-20% w/w.

In a preferred embodiment of the present invention, Clodinafop- propargyl is present in an amount of 10% w/w.

In an embodiment of the present invention, Metribuzin is present in an amount ranging from 10-30% w/w.

In a preferred embodiment of the present invention, Metribuzin is present in an amount of 17% w/w.

In an embodiment of the present invention, Metsulfuron- methyl is present in an amount ranging from 0.1-25% w/w.
In a preferred embodiment of the present invention, Metsulfuron methyl is present in amount of 0.53% w/w.

In an embodiment of the present invention, said vegetable oil is selected from the group consisting of olive oil, sunflower oil, canola oil, coconut oil, safflower oil, corn oil, peanut oil, cottonseed oil, palm-kernel oil, and soybean oil.

In yet another aspect, the present invention provides a method for combating weeds in crops of useful plants without substantial harm to the crops, which comprises treating the useful plants, seeds or cuttings thereof or the locus of the useful plants with a herbicidally active amount of an herbicidal composition.

In an embodiment, said herbicidal composition comprises:
a. Clodinafop - propargyl;
b. Metribuzin;
c. Metsulfuron methyl;
d. at least one safener;
e. at least one vegetable oil; and
f. at one agriculturally acceptable excipient.

In an embodiment of the present invention, Clodinafop- propargyl is present in an amount ranging from 4-20% w/w.

In a preferred embodiment of the present invention, Clodinafop- propargyl is present in an amount of 10% w/w.

In an embodiment of the present invention, Metribuzin is present in an amount ranging from 10-30% w/w.

In a preferred embodiment of the present invention, Metribuzin is present in an amount of 17% w/w.

In an embodiment of the present invention, Metsulfuron- methyl is present in an amount ranging from 0.1-25% w/w.
In a preferred embodiment of the present invention, Metsulfuron methyl is present in amount of 0.53% w/w.

In an embodiment of the present invention, said safener is selected from mefenpyr-diethyl, isoxadifen-ethyl, cloquintocet-mexyl, dichlormid, benoxacor, fenclorim, flurazole, fluxofenim, and combinations thereof.

In a preferred embodiment of the present invention, said safener is cloquintocet-mexyl.

In an embodiment of the present invention, said safener is present in an amount ranging from 1-10% w/w.

In a preferred embodiment of the present invention, said safener is present in an amount of 2.50% w/w.

In an embodiment of the present invention, said vegetable oil is selected from the group consisting of olive oil, sunflower oil, canola oil, coconut oil, safflower oil, corn oil, peanut oil, cottonseed oil, palm-kernel oil, and soybean oil.

In an embodiment of the present invention, said vegetable oil is present in an amount ranging from 0.1-5% w/w.

In a preferred embodiment of the present invention, said vegetable oil is present in an amount of 1% w/w.

In an embodiment of the present invention, said agriculturally acceptable excipient is selected from the group consisting of at least one anti-freeze agent, at least one dispersing agent, at least one wetting agent, at least one deformer, at least one anti-bacterial or biocide, at least one thickener, and a combination thereof.

In a preferred embodiment of the present invention, said agriculturally acceptable excipient comprises a combination of at least a wetting cum dispersing agent, wetting agent, emulsifier and filler.

In an embodiment of the present invention, said at least one wetting cum dispersing agent is selected from the group consisting of alkyl phenol Ethoxylate, salts of alkyl naphthyl sulphonate, salts of alkyl aryl sulphonate, derivative of sulfonated fatty alcohol, anionic sulphonate, blend of aromatic sulphonic acid sodium salt, Blend of alkyl aryl sulphonic acid sodium salt and combination thereof.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is anionic sulphonate.

In an embodiment of the present invention, said wetting cum dispersing agent is present in an amount ranging from 1.0-9.0% w/w.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is present in an amount of 3% w/w.

In an embodiment of the present invention, said at least one wetting agent is selected from the group of consisting of blend of alkyl naphthalene sulfonate, sodium salt, amine salt of poly aryl phenyl ether phosphate, Sodium laurel sulphate, poly alkyl aryl ethylene oxide phosphate ester, taurates and combination thereof.

In a preferred embodiment of the present invention, said wetting agent is taurates.

In an embodiment of the present invention, said wetting agent is present in an amount ranging from 1.0-6.0% w/w.

In a preferred embodiment of the present invention, said wetting agent is present in an amount of 1.50% w/w.

In an embodiment of the present invention, said at least one emulsifier is selected from the group consisting of polyoxyethylenealkyl ether, glycerol monostearate, fatty alcohol alkoxylates and oxoalcohol alkoxylates,sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, alkylpolyglycosides, N-alkylgluconamides, alkylmethyl sulfoxides, alkyldimethylphosphine, fatty Alcohol Alkoxylate and combination thereof.

In a preferred embodiment of the present invention, said emulsifier is fatty Alcohol Alkoxylate.
In an embodiment of the present invention, said emulsifier is present in an amount ranging from 15.0-40.0% w/w.

In a preferred embodiment of the present invention, said emulsifier is present in an amount of 25% w/w.

In an embodiment of the present invention, said at least one filler is selected from the group consisting of silicone emulsions, precipitate silica, long-chain alcohols, fatty acids, organic fluorine compounds and combinations thereof.

In a preferred embodiment of the present invention, said filler is precipitate silica.

In an embodiment of the present invention, said filler is present in an amount ranging from 15.0-65.0% w/w.

In a preferred embodiment of the present invention, said filler is present in amount of 40.47% w/w.

In a preferred embodiment of the present invention, said wetting cum dispersing agent is present in an amount of 3% w/w, wetting agent is present in an amount of 1.50% w/w, emulsifier is present in an amount of 25% w/w, and filler is present in an amount of 40.47% w/w.

In a preferred embodiment, said herbicidal composition comprises:
a. Clodinafop - propargyl is present in an amount of 10% w/w;
b. Metribuzin is present in an amount of 17% w/w;
c. Metsulfuron methyl is an amount of 0.53% w/w;
d. at least one safener is present in an amount of 2.50% w/w;
e. at least one vegetable oil in an amount of 1% w/w; and
f. at least one agriculturally acceptable excipient.

In an embodiment of the present invention, said herbicidal composition is formulated in a form selected from the group comprising water-soluble concentrates (SL), emulsifiable concentrates (EC), emulsions (EW), micro-emulsions (ME), Suspension concentrates (SC), oil-based suspension concentrates (OD), flowable suspensions (FS), wettable granules (WG), water-soluble granules (SG), wettable powders (WP), water-dispersible granule (WDG). water soluble powders (SP), granules (GR), encapsulated granules (CG), fine granules (FG), macrogranules (GG), dry flowables (DF), aqueous suspo-emulsions (SE), capsule suspensions (CS) and microgranules (MG).

In a preferred embodiment of the present invention, said herbicidal composition is in the form of wettable granule (WG).

In a preferred embodiment of the present invention, said herbicidal composition is applied at the dosage of 300-1000g/ha to the crops.

The examples of weeds controlled by the present herbicidal composition in the initial field evaluation are Echinocloa colonum, Commelina bengalensis, Cyanotis axillaris, Setaria glauca, Parthenium hysterophorus, Cilosia indica, Phalaris miner, Chenopodium album, Fumarai etc.

The herbicidal composition of the present invention has an outstanding herbicidal activity against monocotyledonous and dicotyledonous weeds, the tolerant, or cross-tolerant, cereal plants such as wheat, rye, barley, oats etc.

The foregoing description of the embodiments has been provided for purposes of illustration and not intended to limit the scope of the present invention. Individual components of a particular embodiment are generally not limited to that particular embodiment but are interchangeable. Such variations are not to be regarded as a departure from the present invention, and all such modifications are considered to be within the scope of the present invention.

The present invention is further described in light of the following experiments which are set forth for illustration purposes only and not to be construed for limiting the scope of the invention. The following experiments can be scaled up to industrial/commercial scale and the results obtained can be extrapolated to industrial scale.
EXAMPLES
The examples below are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.

Example 1: Preparation of herbicidal composition as wettable granules (WG).

Table 1 below provides an herbicidal composition as described in the present invention, formulated as wettable granules (WG).

Table 1: Chemical Composition of CCP 10153 WG
Ingredients Tentative percentage w/w
Clodinafop- propargyl technical (Basis of 100.0%) 10% w/w
Metribuzin technical (Basis of 100.0%) 17% w/w
Metsulfuron-methyl technical (Basis of 100.0%) 0.53% w/w
Safener (Cloquintocet mexyl) 2.50% w/w
Vegetable oil 1% w/w
Wetting cum dispersing agent (anionic sulphonate) 3% w/w
Wetting agent (taurate) 1.50% w/w
Emulsifier (Fatty Alcohol Alkoxylate) 25% w/w
Filler (precipitate silica) 40.47% w/w
D.M Water QS to 100%

Table 2: Quality parameters of WG formulation
S. No. Parameter Desired quality
1 Description Description – the material shall consist of dry, free flowing powder, shall wet on mixing with water providing solution suitable for spray. The material shall be free from visible extraneous matter.
2 A.I. Content Clodinafop- propargyl - 10% w/w (±5%)
Metribuzin - 17% w/w (±5%)
Metsulfuron-methyl – 0.53% (±5%)
Cloquintocet Mexyl – 2.50% (±5%)
3 Persistent foaming not more than 60 ml after 1 min
4 Wettability max 60 sec.
5 Suspensibility Suspensibility- 75% min.
6 Acidity Acidity as H2SO4 – 0.5% max

Example 2: Field evaluation of the bio efficacy of the present herbicidal composition
The presently disclosed herbicidal trimix (coded as CCP 10153 WG) was tested for its bio efficacy against narrow leaved, broad leaved and sedges weeds in wheat crop in a local variety during Rabi season 2022 at Hisar, Haryana. The plants were aligned in the plot size of 50 sq meter. The trial was laid out in a random block design consisting of a total of 13 treatments in three replications. The trial was conducted at a temperature of 23ºC under 87% relative humidity, no winds and under optimum soil moisture conditions.

Measured quantity of the chemical was added to required volume of water @ 375 lit. /ha for spraying. The spray tank was filled with ½ the quantity of clean required volume of water and then the measured chemical (according to the dose) was added followed by the rest half quantity of water. The solution was stirred well before application. Knapsack sprayer fitted with boom along with flood jet nozzle was used to apply the herbicidal solution.

Table 3 below provides the treatment details of the wheat crop in the trial experiment conducted. For convenience, the present composition has been represented by the code “CCP 10153 WG”.

S. No. Treatments a.i (g)/ha (ml/g)/ha
1. Untreated - -
2. CCP-71545 WG 35 + 75 + 2.25 +5 500
3. CCP-0715 WP 35 + 75 + 2.25 500
4. CCP-10153 WG 50 + 85 + 2.65 + 5 500
5. CCP-1017 WP 50 + 85 + 2.65 500
6. CCP-12206 WG 60 + 100 + 3.0 + 5 500
7. CCP-1220 WP 60 + 100 500
8. CCP-71545 WG 70 + 75 + 2.25 + 5 500
9. CCP-0715 WP 70 + 75 500
10. Clodinafop 15 WP 60 400
11. Metsulfuron methyl 20% WP 4 20
12. Metribuzin 70% WP 525 750

Note:
CCP-71545 WG Clodinafop 07%+Metribuzin 15%+Metsulfuron 0.45 + Vegetable oil 1% WP
CCP-0715 WP Clodinafop 07%+Metribuzin 15%+Metsulfuron 0.45 WP
CCP-10153 WG Clodinafop 10%+Metribuzin 17%+Metsulfuron 0.53 WP + Vegetable oil 1% WP
CCP-1017 WP Clodinafop 10%+Metribuzin 17%+Metsulfuron 0.53 WP
CCP-12206 WG Clodinafop 12%+Metribuzin 20%+Metsulfuron 0.60 WP + Vegetable oil 1% WP
CCP-1220 WP Clodinafop 12%+Metribuzin 20%+Metsulfuron 0.60 WP
CCP-71545 WG Clodinafop 07%+Metribuzin 15%+Metsulfuron 0.45 WP + Vegetable oil 1% WP
CCP-0715 WP Clodinafop 07%+Metribuzin 15%+Metsulfuron 0.45 WP

EVALUATION OF BIO-EFFICACY AGAINST WEEDS MANAGEMENT

Evaluation Method for Weeds Management
Weed count: A quadrate (0.5m × 0.5m) was placed at 3 randomly selected places in all the plots of the experimental field and the number of weed flora were counted uniformly at 15 and 30 days after application.

Weed control: The weed control was calculated based on no. of live weed flora at 15 and 30 days after application.
Percent weed control = WC – WT
…………. × 100
WC
Where WC= No. of weed in control plot
WT= No. of weed in treated plot

Table 4a: Effect of herbicidal treatment on weed density of narrow leaved weeds at 14,21 and 28 DAA.
Treatments gm a.i./Ha Dose/Ha % Population reduction (Phalaris minor)
14 DAA % Control 21 DAA % Control 28 DAA % Control
Untreated - - 19 - 25 - 27 -
CCP-71545 WG 35 + 75 + 2.25 +5 500 5 73.68 5 80.00 5 81.48
CCP-0715 WP 35 + 75 500 7.5 60.53 7.5 70.00 7.5 72.22
CCP-10153 WG 50 + 85 + 2.65 + 5 500 1.5 92.11 1.5 94.00 1.5 94.44
CCP-1017 WP 50 + 85 + 2.65 500 4 78.95 3 88.00 2.7 90.00
CCP-12206 WG 60 + 100 + 3.0 + 5 500 1.9 90.00 1.9 92.40 1.9 92.96
CCP-1220 WP 60 + 100 500 2.1 88.95 2.1 91.60 2.1 92.22
CCP-71545 WG 70 + 75 + 2.25 + 5 500 7.9 58.42 7.9 68.40 7.9 70.74
CCP-0715 WP 70 + 75 500 8.5 55.26 8.5 66.00 8.5 68.52
MKTS-1 60 400 11 42.11 11 56.00 11 59.26
MKTS-2 4 20 16 15.79 16 36.00 16 40.74
MKTS-3 525 750 9 52.63 9 64.00 9 66.67
Note:
MKTS-1: Clodinofop 15% WP
MKTS-2: Metsulfuron methyl 20% WP
MKTS-3: Metribuzin 70% WP

As seen in Table 4a, treatment with Clodinafop- propargyl alone at 60 g a.i/ha results in about 42.11% control of the weeds in 14 DAA. Metribuzin alone at 525 g a.i/ha results in about 52.63% control of the weeds in 14 DAA. Treatment with Metsulfuron-methyl alone at 4g/ha results in 15.79% control of the weeds in 14 DAA. However, unexpectedly and surprisingly, advantageously, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl + vegetable oil at dosage of 50 g a.i/ha + 85 g a.i/ha + 2.65 g a.i/ha + 5 g a.i/ha respectively results in about 92.11% control of the weeds in 14 DAA. It can be observed that when the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl + vegetable oil is applied, it synergistically enhances the overall activity of the herbicidal composition. The results obtained were superior to other combinations at different weight concentrations.

Further as seen in above table, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl (without vegetable oil) results in 78.95% control of the weeds in 14 DAA. However, unexpectedly and surprisingly, advantageously, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl + vegetable oil results in about 92.11% control of the weeds in 14 DAA.
Table 4b: Effect of herbicidal treatment on weed density of broad leaves weeds at 14 DAA, 21 DAA and 28 DAA.
Treatments gm a.i./Ha Dose/Ha % Population reduction (Chenopodium album)
14 DAA % Control 21 DAA % Control 28 DAA % Control
Untreated 17 19 24
CCP-71545 WG 35 + 75 + 2.25 +5 500 6 64.71 7 63.16 8 66.67
CCP-0715 WP 35 + 75 500 8 52.94 9 52.63 10 58.33
CCP-10153 WG 50 + 85 + 2.65 + 5 500 1.6 90.59 1.5 92.11 1.2 95.00
CCP-1017 WP 50 + 85 + 2.65 500 2.9 82.94 2.2 88.42 3 87.50
CCP-12206 WG 60 + 100 + 3.0 + 5 500 2 88.24 1.9 90.00 1.6 93.33
CCP-1220 WP 60 + 100 500 2.4 85.88 2.1 88.95 1.5 93.75
CCP-71545 WG 70 + 75 + 2.25 + 5 500 8 52.94 7.5 60.53 7.9 67.08
CCP-0715 WP 70 + 75 500 9 47.06 7.9 58.42 8.5 64.58
Clodinofop 15 WP 60 400 15 11.76 16 15.79 18 25.00
Metsulfuron methyl 20% WP 4 20 8 52.94 6 68.42 9 62.50
Metribuzin 70% WP 525 750 6 64.71 5 73.68 7 70.83

As seen in Table 4b, treatment with Clodinafop- propargyl alone at 60 g a.i/ha results in about 11.76% control of the weeds in 14 DAA. Metribuzin alone at 525 g a.i/ha results in about 64.71% control of the weeds in 14 DAA. Treatment with Metsulfuron-methyl alone at 4g/ha results in 52.94% control of the weeds in 14 DAA. However, unexpectedly and surprisingly, advantageously, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl + vegetable oil at dosage of 50 g a.i/ha + 85 g a.i/ha + 2.65 g a.i/ha + 5 g a.i/ha respectively results in about 90.59% control of the weeds in 14 DAA. It can be observed that when the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl + vegetable oil is applied, it synergistically enhances the overall activity of the herbicidal composition. The results obtained were superior to other possible combinations at different weight concentrations.
Further as seen in above table, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl (without vegetable oil) results in 82.59% control of the weeds in 14 DAA. However, unexpectedly and surprisingly, advantageously, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl along with vegetable oil results in about 90.59% control of the weeds in 14 DAA.

Table 4c: Effect of herbicidal treatment on weed density of broad leaves weeds at 14 DAA, 21 DAA and 28 DAA.

Treatments gm a.i./Ha Dose/Ha % Population reduction (Fumaria spp.)
14 DAA % Control 21 DAA % Control 28 DAA % Control
Untreated 15 17 19
CCP-71545 WG 35 + 75 + 2.25 +5 500 7 53.33 8 52.94 9 52.63
CCP-0715 WP 35 + 75 500 9 40.00 10 41.18 11 42.11
CCP-10153 WG 50 + 85 + 2.65 + 5 500 0 100.00 0 100.00 1 94.74
CCP-1017 WP 50 + 85 + 2.65 500 1 93.33 1 94.12 2 89.47
CCP-12206 WG 60 + 100 + 3.0 + 5 500 3 80.00 2 88.24 3 84.21
CCP-1220 WP 60 + 100 500 4 73.33 3 82.35 2 89.47
CCP-71545 WG 70 + 75 + 2.25 +5 500 6 60.00 5 70.59 6 68.42
CCP-0715 WP 70 + 75 500 7 53.33 6 64.71 7 63.16
Clodinofop 15 WP 60 400 14 6.67 15 11.76 17 10.53
Metsulfuron methyl 20% WP 4 20 5 66.67 7 58.82 8 57.89
Metribuzin 70% WP 525 750 4 73.33 5 70.59 6 68.42

As seen in Table 4c, treatment with Clodinafop- propargyl alone at 60 g a.i/ha results in about 6.67% control of the weeds in 14 DAA. Metribuzin alone at 525 g a.i/ha results in about 73.33% control of the weeds in 14 DAA. Treatment with Metsulfuron-methyl alone at 4g/ha results in 66.67% control of the weeds in 14 DAA. However, unexpectedly and surprisingly, advantageously, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl + vegetable oil at dosage of 50 g a.i/ha + 85 g a.i/ha + 2.65 g a.i/ha + 5 g a.i/ha respectively results in about 100% control of the weeds in 14 DAA. It can be observed that when the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl + vegetable oil is applied, it synergistically enhances the overall activity of the herbicidal composition. The results obtained were superior to other possible combinations at different weight concentrations.

Further as seen in above table, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl (without vegetable oil) results in 93.33% control of the weeds in 14 DAA. However, unexpectedly and surprisingly, advantageously, the combination of Clodinafop- propargyl + Metribuzin + Metsulfuron-methyl along with vegetable oil results in about 100% control of the weeds in 14 DAA.

Example 3: Evaluation of Phytotoxicity
Visual observations were recorded at 3, 7 and 10 days after application (DAA) of testing products. The parameters were observed leaf injury on tip/surface, necrosis, vein clearing, epinasty, hyponasty and wilting. The score scale (1-10) followed for leaf injury on tips/surface is given.

Table 5: Phytotoxicity symptoms scoring and rating for leaf injury on tip/surface.
Leaf injury on tips/surface Rating
0-10% 1
11-20% 2
21-30% 3
31-40% 4
41-50% 5
51-60% 6
61-70% 7
71-80% 8
81-90% 9
91-100% 10

Table 6 (a): Phytotoxic effect of various treatments on Wheat crop after 3 DAA

Table 6 (b): Phytotoxic effect of various treatments on Wheat crop after 7 DAA

Table 6 (c): Phytotoxic effect of various treatments on Wheat crop after 10 DAA

Note:
MKTS-1: Clodinofop 15% WP
MKTS-2: Metsulfuron methyl 20% WP
MKTS-3: Metribuzin 70% WP

As seen in Table 6 (a), (b) and (c), there is no phytotoxicity associated with treatment of any of the ingredients to the plants, suggesting that said composition is completely safe to use.
The present invention provides a novel and synergistic combination of Clodinafop- propargyl, Metribuzin, Metsulfuron-methyl and vegetable oil, which significantly enhances the economic value of crops. While the present specification illustrates various concentrations across which enhanced results are seen, in particular, the combination of Clodinafop- propargyl, Metribuzin, Metsulfuron methyl and vegetable oil at dosage of 50 gm a.i/ha, 85 gm a.i/ha, 2.65 gm a.i/ha and 5 gm a.i/ha respectively shows the best results in controlling weeds. There is a clear and significant enhancement which is not anticipated or expected.

From the foregoing it will be observed that numerous modifications and variations can be effectuated without departing from the true spirit and scope of the novel concepts of the present invention. It is to be understood that no limitations with respect to the specific embodiments illustrated is intended or should be inferred. It should be understood that all such modifications and improvements have been deleted herein for the sake of conciseness and readability but are properly within the scope of the following claims.
, Claims:We Claim:
1. An herbicidal composition comprising:
a. Clodinafop- propargyl in an amount ranging from 4-20% w/w;
b. Metribuzin in an amount ranging from 10-30% w/w;
c. Metsulfuron methyl in amount ranging from 0.1-25% w/w;
d. at least one safener in an amount ranging from 1-10% w/w;
e. at least one vegetable oil in an amount ranging from 0.1-5%w/w; and
f. at least one agriculturally acceptable excipient.

2. The herbicidal composition as claimed in claim 1, wherein said safener is selected from mefenpyr-diethyl, isoxadifen-ethyl, cloquintocet-mexyl, dichlormid, benoxacor, fenclorim, flurazole, fluxofenim, and combinations thereof.

3. The herbicidal composition as claimed in claim 2, wherein said safener is cloquintocet-mexyl.

4. The herbicidal composition as claimed in claim 1, wherein said agriculturally acceptable excipient is selected from the group comprising of wetting cum dispersing agent, wetting agent, emulsifier, deformer, demineralized water, adjuvant, or any combinations thereof.

5. The herbicidal composition as claimed in claim 4, wherein said wetting cum dispersing agent is present in an amount ranging from 1.0-9.0% w/w, wetting agent is present in an amount 1.0-6.0% w/w, emulsifier is present in an amount 15.0-40.0% w/w, and filler is present in an amount of 15.0-65.0% w/w.

6. The herbicidal composition as claimed in claim 1, wherein said herbicidal composition comprises:
a. Clodinafop- propargyl is present in amount of 10% w/w;
b. Metribuzin is present in amount of 17% w/w;
c. Metsulfuron methyl is present in amount of 0.53% w/w;
d. at least one safener is present in an amount of 2.50% w/w;
e. at least one vegetable oil in an amount of 1% w/w; and
f. at least one agriculturally acceptable excipients.
7. The herbicidal composition as claimed in claim 1, wherein said herbicidal composition is in a form selected from the group comprising of water-soluble concentrates (SL), emulsifiable concentrates (EC), emulsions (EW), micro-emulsions (ME), Suspension concentrates (SC), oil-based suspension concentrates (OD), flowable suspensions (FS), water-dispersible granules (WDG), wettable granules (WG) water-soluble granules (SG), wettable powders (WP), water soluble powders (SP), granules (GR), encapsulated granules (CG), fine granules (FG), macro granules (GG), dry flowable (DF), aqueous Suspo-emulsions (SE), capsule suspensions (CS) and microgranules (MG).

8. The herbicidal composition as claimed in claim 7, wherein said herbicidal composition is wettable granules (WG).

9. A process for the preparation of an herbicidal composition in wettable granules formulation (WG), the process comprises:
a. obtaining a homogeneous mixture of at least one wetting cum dispersing agent, wetting agent, emulsifier and filler;
b. adding Clodinafop- propargyl technical, Metribuzin technical., Metsulfuron methyl technical and Cloquintocet Mexyl to the homogenous mixture of step (a);
c. mixing the mixture of step (b) in a blender;
d. grinding the mixture of step (c) in a jet mill to obtain a particle having size less than 10 microns;
e. blending the mass obtained in step (d) (Post blending mix) to obtain a homogenous mass;
f. transferring the blended material obtained in step (e) into a post blender;
g. adding vegetable oil to the mixture obtained in step (f) and mix well to get a uniform powder.

10. The process as claimed in claim 9, wherein said safener is cloquintocet-mexyl present in an amount of 2.50% w/w.

11. The process as claimed in claim 9, wherein said wetting cum dispersing agent is present in an amount 3.0% w/w, wetting agent is present in an amount 1.50% w/w, emulsifier is present in an amount 25.0% w/w, and deformer is present in an amount of 40.47% w/w.

12. A method for combating weeds in crops of useful plants without causing substantial harm to the crops, which comprises treating the useful plants, seeds or cuttings thereof or the locus of the useful plants with a herbicidally active amount of a herbicidal composition.

13. The method as claimed in claim 12, wherein said herbicidal composition comprising:
a. Clodinafop- propargyl in an amount ranging from 4-20% w/w;
b. Metribuzin in an amount ranging from 10-30% w/w;
c. Metsulfuron methyl in an amount ranging from 0.1-25% w/w;
d. at least one safener in an amount ranging from 1-10% w/w;
e. at least one vegetable oil in an amount ranging from 0.1-5%; and
f. at least one agriculturally acceptable excipient.

14. The method as claimed in claim 12, wherein said safener is cloquintocet-mexyl.

15. The method as claimed in claim 12, wherein said agriculturally acceptable excipient is selected from the group comprising of wetting cum dispersing agent, wetting agent, emulsifier, deformer, demineralized water, adjuvant, or any combinations thereof.

16. The method as claimed in claim 12, wherein said herbicidal composition is in a form selected from the group comprising of water-soluble concentrates (SL), emulsifiable concentrates (EC), emulsions (EW), micro-emulsions (ME), Suspension concentrates (SC), oil-based suspension concentrates (OD), flowable suspensions (FS), water-dispersible granules (WG), wettable granules (WG) water-soluble granules (SG), wettable powders (WP), water soluble powders (SP), granules (GR), encapsulated granules (CG), fine granules (FG), macro granules (GG), dry flowable (DF), aqueous Suspo-emulsions (SE), capsule suspensions (CS) and microgranules (MG).

17. The method as claimed in claim 16, wherein said herbicidal composition is applied in the form of wettable granules (WG).