Hetero Ring Derivative

Abstract: [Abstract] [Object] A novel and excellent method for preventing or treating rejection in the transplantation of various organs, allergy diseases, autoimmune diseases, hematologic tumor, or the like, based on a PDK5-selective inhibitory action and/or an IL-2 production inhibitory action, and/or a B cell proliferation inhibitory action (including an activation inhibitory action), is provided [Means for Solution] It was found that a 3-substituted triazine or 3-substituted pyrimidine derivative exhibits a PI3K5-selective inhibitory action, and/or an EL-2 production inhibitory action, and/or a B cell proliferation inhibitory action (including an activation inhibitory action), and can be an agent for preventing or treating rejection in the transplantation of various /""\ 15 organs, allergy diseases (asthma, atopic dermatitis, etc.), autoimmune diseases (rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, etc.), hematologic tumor (leukemia etc.), or the like, thereby completing the present invention. [Selected Figure] None

Patent Information

Application #

Filing Date

12 August 2011

Publication Number

51/2014

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

ASTELLAS PHARMA INC.

3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU, TOKYO 1038411

Inventors

1. TAKAHASHI, FUMIT

C/O ASTELLAS PHARMA INC., 3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU, TOKYO 103-8411

2. IMADA, SUNAO

C/O ASTELLAS PHARMA INC., 3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU, TOKYO 103-8411

3. SHIWAKU, MASAHIKO (DECEASED)

C/O ASTELLAS PHARMA INC, 3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU, TOKYO 103-8411

4. SHIWAKU, YASUMASA AND SHIWAKU, ATSUKO (LEGAL HEIRS OF SHIWAKU, MASAHIKO (DECEASED)

16, OHMACHI 2-CHOME, AKOU-SHI, HYOUGO 678-0205

5. KATO, KOJI

C/O ASTELLAS PHARMA INC., 3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU, TOKYO 103-8411

6. FUKAHORI, HIDEHIKO

C/O ASTELLAS PHARMA INC., 3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU, TOKYO 103-8411

Specification

PLS SEE ATTACHEMENT.

Documents

Application Documents

#	Name	Date
1	5869-CHENP-2011 DESCRIPTION(COMPLETE) 12-08-2011.pdf	2011-08-12
1	5869-CHENP-2011-Form-13-120811.pdf	2016-11-30
2	5869-CHENP-2011 CLAIMS 12-08-2011.pdf	2011-08-12
2	5869-CHENP-2011 FORM-3 19-01-2012.pdf	2012-01-19
3	5869-CHENP-2011 CORRESPONDENCE OTHERS 19-01-2012.pdf	2012-01-19
3	5869-CHENP-2011 POWER OF ATTORNEY 12-08-2011.pdf	2011-08-12
4	5869-CHENP-2011 ABSTRACT 12-08-2011..pdf	2011-08-12
4	5869-CHENP-2011 PCT 12-08-2011..pdf	2011-08-12
5	5869-CHENP-2011 FORM-5 12-08-2011..pdf	2011-08-12
5	5869-CHENP-2011 CORRESPONDENCE OTHERS 12-08-2011..pdf	2011-08-12
6	5869-CHENP-2011 FORM-3 12-08-2011..pdf	2011-08-12
6	5869-CHENP-2011 FORM-1 12-08-2011..pdf	2011-08-12
7	5869-CHENP-2011 FORM-2 12-08-2011..pdf	2011-08-12
7	5869-CHENP-2011 FORM-13 12-08-2011..pdf	2011-08-12
8	5869-CHENP-2011 FORM-2 12-08-2011..pdf	2011-08-12
8	5869-CHENP-2011 FORM-13 12-08-2011..pdf	2011-08-12
9	5869-CHENP-2011 FORM-3 12-08-2011..pdf	2011-08-12
9	5869-CHENP-2011 FORM-1 12-08-2011..pdf	2011-08-12
10	5869-CHENP-2011 CORRESPONDENCE OTHERS 12-08-2011..pdf	2011-08-12
10	5869-CHENP-2011 FORM-5 12-08-2011..pdf	2011-08-12
11	5869-CHENP-2011 ABSTRACT 12-08-2011..pdf	2011-08-12
11	5869-CHENP-2011 PCT 12-08-2011..pdf	2011-08-12
12	5869-CHENP-2011 CORRESPONDENCE OTHERS 19-01-2012.pdf	2012-01-19
12	5869-CHENP-2011 POWER OF ATTORNEY 12-08-2011.pdf	2011-08-12
13	5869-CHENP-2011 CLAIMS 12-08-2011.pdf	2011-08-12
13	5869-CHENP-2011 FORM-3 19-01-2012.pdf	2012-01-19
14	5869-CHENP-2011-Form-13-120811.pdf	2016-11-30
14	5869-CHENP-2011 DESCRIPTION(COMPLETE) 12-08-2011.pdf	2011-08-12