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Heteroaryl Carboxamide Compound
Abstract: Provided is a compound which is useful as an active ingredient for a pharmaceutical composition for treating cancer associated with the activation of an immunocyte or cancer having resistance to an anti-PD-1 antibody/anti-PD-L1 antibody therapy. The present inventors have studied about a compound useful as an active ingredient for a pharmaceutical composition for treating cancer associated with the activation of an immunocyte or cancer having resistance to an anti-PD-1 antibody/anti-PD-L1 antibody therapy. As a result, it is confirmed that a heteroaryl carboxamide compound has a DGK? (DGKzeta) inhibiting activity, and this confirmation leads to the accomplishment of the present invention. The heteroaryl carboxamide compound according to the present invention has a DGK? inhibiting activity, and can be used as a therapeutic agent for cancer associated with the activation of an immunocyte or cancer having resistance to an anti-PD-1 antibody/anti-PD-L1 antibody therapy.
Notices, Deadlines & Correspondence
Patent Information
Applicants
ASTELLAS PHARMA INC.
KOTOBUKI PHARMACEUTICAL CO., LTD.
Inventors
1. WATANABE, Hideyuki
2. KAMIKUBO, Takashi
3. KAMIKAWA, Akio
4. WASHIO, Takuya
5. SEKI, Yohei
6. OKUYAMA, Keiichiro
7. IKEDA, Osamu
8. TOMIYAMA, Hiroshi
9. IWAI, Yoshinori
10. NAKAMURA, Akihiko
11. MIYASAKA, Kozo
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202347038971-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [07-06-2023(online)].pdf | 2023-06-07 |
| 2 | 202347038971-STATEMENT OF UNDERTAKING (FORM 3) [07-06-2023(online)].pdf | 2023-06-07 |
| 3 | 202347038971-PROOF OF RIGHT [07-06-2023(online)].pdf | 2023-06-07 |
| 4 | 202347038971-PRIORITY DOCUMENTS [07-06-2023(online)].pdf | 2023-06-07 |
| 5 | 202347038971-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [07-06-2023(online)].pdf | 2023-06-07 |
| 6 | 202347038971-FORM 1 [07-06-2023(online)].pdf | 2023-06-07 |
| 7 | 202347038971-DECLARATION OF INVENTORSHIP (FORM 5) [07-06-2023(online)].pdf | 2023-06-07 |
| 8 | 202347038971-COMPLETE SPECIFICATION [07-06-2023(online)].pdf | 2023-06-07 |
| 9 | 202347038971-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [07-06-2023(online)].pdf | 2023-06-07 |
| 10 | 202347038971.pdf | 2023-06-18 |
| 11 | 202347038971-RELEVANT DOCUMENTS [26-06-2023(online)].pdf | 2023-06-26 |
| 12 | 202347038971-MARKED COPIES OF AMENDEMENTS [26-06-2023(online)].pdf | 2023-06-26 |
| 13 | 202347038971-FORM 13 [26-06-2023(online)].pdf | 2023-06-26 |
| 14 | 202347038971-Annexure [26-06-2023(online)].pdf | 2023-06-26 |
| 15 | 202347038971-AMMENDED DOCUMENTS [26-06-2023(online)].pdf | 2023-06-26 |
| 16 | 202347038971-FORM-26 [13-07-2023(online)].pdf | 2023-07-13 |
| 17 | 202347038971-FORM 3 [16-11-2023(online)].pdf | 2023-11-16 |
| 18 | 202347038971-FORM 18 [30-10-2024(online)].pdf | 2024-10-30 |