"Humanized Antibodies That Recognize Verotoxin Ii And Cell Line

"Humanized Antibodies That Recognize Verotoxin Ii And Cell Line Producing Same"

Abstract: The present invention discloses a combination of recombinant DNA and monoclonal antibody technologies to develop novel biologies for treating verotoxin producing E. coli (VTEC) infection for which no effective drug exists. Murine monoclonal antibodies, which neutralize verotoxin II, a verotoxin produced during VTEC infection, are known but the known antibodies have certain drawbacks for human treatment. The present invention provides improved humanized monoclonal antibodies that specifically bind to and neutralize verotoxin II, are substantially non-immunogenic in humans, and can be produced in a manner suitable for therapeutic use. The pharmaceutical compositions comprising humanized monoclonal antibodies are suitable for treating patients suffering or at risk of toxic effects from VTEC infection.

Patent Information

Application #

Filing Date

20 December 2000

Publication Number

38/05

Publication Type

INA

Invention Field

NO SUBJECT

Status

Email

Parent Application

Applicants

TEIJIN LIMITED

6-7, MNAMIHOMMACHI 1-CHOME, CHUO-KU, OSAKA-SHI, OSAKA

PROTEIN DESIGN LABS, INC.

34801 CAMPUS DRIVE, FREMONT, CA-94555

Inventors

1. MATSUMOTO YOH-ICHI

7-9-105, TATENOCHO, NERIMAKU, TOKYO 177-0054

2. IMAIZUMI ATSUCHI

5-10-8, NISHI-HIRAYAMA, HINO CITY, TOKYO 191-0055

3. KIMURA TSUYOSHI

2-19-2-401, ASAHIGAOKI, HINO CITY, TOKYO 191-0065

4. TAKEDO TAE

2-1-3, NUKUI-KITAMACHI, KOGANEI CITY TOKYO 184-0015

5. CO MANG SUNG

10952 WILKINSON AVENUE, CUPERTINO CA 95014

6. VASQUES MAXIMILIANO

3813 LOUIS ROAD, PALO ALTO, CA 94303