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Hydrogen Sulfide Probe For Cancer Biomarker
Abstract: The invention discloses a fluorescence probe with mitochondrial targeting and two-photon property, its preparation method and application in detecting and tracking endogenous H2S in samples or living cells. The fluorescent probe is prepared by a four-step preparation method and demonstrates a UV-vis absorption increment ?ab= 395 nm and ~ 43 fold higher fluorescence intensity in the presence of H2S. The probe further demonstrates stability, selectivity for H2S over competing agents and sensitivity as low as 20 nm. A method of detecting endogenous H2S rapidly in the absence of any external stimulators is provided. Samples are contacted with the probe and the changes in fluorescence are monitored to detect H2S levels. The disclosed probe is non-toxic and suitable as a biomarker and therapeutic molecule in cancer and other diseases.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
18 April 2017
Publication Number
43/2018
Publication Type
INA
Invention Field
PHYSICS
Status
Email
paralegal.maxval@maxval.com
Parent Application
Patent Number
Legal Status
Grant Date
2024-12-18
Renewal Date
Applicants
Amrita Vishwa Vidyapeetham
Amrita School Of Engineering,
Amritanagar,
Coimbatore,Tamil Nadu,
India-
Inventors
1. Mr. SANKARPRASAD BHUNIYA
Amrita Centre for Industrial Research &Innovation, Amrita School of engineering, Coimbatore, Amrita University, India 64112.
2. Ms. NANDITA MISHRA
School of Biotechnology, Amrita University, Kollam, Kerala, India 695019.
3. Mr. KONDAPA NAIDU BOBBA
Amrita Centre for Industrial Research &Innovation, Amrita School of engineering, Coimbatore, Amrita University, India 64112.
4. Ms. NITHYA VELUSAMY
Amrita Centre for Industrial Research &Innovation, Amrita School of engineering, Coimbatore, Amrita University, India 64112.
5. Ms. ANUPAMA BINOY
School of Biotechnology, Amrita University, Kollam, Kerala, India 695019.
6. Ms. DIVYA NEDUNGADI
School of Biotechnology, Amrita University, Kollam, Kerala, India 695019.
Specification
DESC:As attached. ,CLAIMS:As attached.
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
| u/s15 | RESMI C SENAN | 2021-07-23 |
| 43 | RESMI C SENAN | 2024-12-18 |
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 201741013739- Certificate of Inventorship-044000212( 19-03-2025 ).pdf | 2025-03-19 |
| 1 | 201741013739-EDUCATIONAL INSTITUTION(S) [07-03-2025(online)].pdf | 2025-03-07 |
| 1 | 201741013739-IntimationOfGrant18-12-2024.pdf | 2024-12-18 |
| 1 | 201741013739-Written submissions and relevant documents [12-11-2024(online)].pdf | 2024-11-12 |
| 1 | Form 3 [18-04-2017(online)].pdf | 2017-04-18 |
| 2 | 201741013739- Certificate of Inventorship-044000213( 19-03-2025 ).pdf | 2025-03-19 |
| 2 | 201741013739-Correspondence to notify the Controller [25-10-2024(online)].pdf | 2024-10-25 |
| 2 | 201741013739-EVIDENCE FOR REGISTRATION UNDER SSI [07-03-2025(online)].pdf | 2025-03-07 |
| 2 | 201741013739-PatentCertificate18-12-2024.pdf | 2024-12-18 |
| 2 | Description(Provisional) [18-04-2017(online)].pdf | 2017-04-18 |
| 3 | 201741013739-FORM 8A [18-03-2025(online)]-1.pdf | 2025-03-18 |
| 3 | 201741013739-FORM-26 [27-09-2017(online)].pdf | 2017-09-27 |
| 3 | 201741013739-IntimationOfGrant18-12-2024.pdf | 2024-12-18 |
| 3 | 201741013739-Response to office action [03-12-2024(online)].pdf | 2024-12-03 |
| 3 | 201741013739-ReviewPetition-HearingNotice-(HearingDate-28-10-2024).pdf | 2024-09-26 |
| 4 | 201741013739-FER.pdf | 2021-10-17 |
| 4 | 201741013739-FORM 8A [18-03-2025(online)].pdf | 2025-03-18 |
| 4 | 201741013739-PatentCertificate18-12-2024.pdf | 2024-12-18 |
| 4 | 201741013739-Written submissions and relevant documents [12-11-2024(online)].pdf | 2024-11-12 |
| 4 | Correspondence by Agent_Power of Attorney_04-10-2017.pdf | 2017-10-04 |
| 5 | 201741013739-US(14)-HearingNotice-(HearingDate-11-06-2021).pdf | 2021-10-17 |
| 5 | 201741013739-Response to office action [03-12-2024(online)].pdf | 2024-12-03 |
| 5 | 201741013739-Proof of Right (MANDATORY) [02-11-2017(online)].pdf | 2017-11-02 |
| 5 | 201741013739-EDUCATIONAL INSTITUTION(S) [07-03-2025(online)].pdf | 2025-03-07 |
| 5 | 201741013739-Correspondence to notify the Controller [25-10-2024(online)].pdf | 2024-10-25 |
| 6 | 201741013739-Written submissions and relevant documents [12-11-2024(online)].pdf | 2024-11-12 |
| 6 | 201741013739-ReviewPetition-HearingNotice-(HearingDate-28-10-2024).pdf | 2024-09-26 |
| 6 | 201741013739-FORM-24 [17-09-2021(online)].pdf | 2021-09-17 |
| 6 | 201741013739-EVIDENCE FOR REGISTRATION UNDER SSI [07-03-2025(online)].pdf | 2025-03-07 |
| 6 | 201741013739-ENDORSEMENT BY INVENTORS [09-03-2018(online)].pdf | 2018-03-09 |
| 7 | 201741013739-Correspondence to notify the Controller [25-10-2024(online)].pdf | 2024-10-25 |
| 7 | 201741013739-DRAWING [09-03-2018(online)].pdf | 2018-03-09 |
| 7 | 201741013739-FER.pdf | 2021-10-17 |
| 7 | 201741013739-FORM-26 [15-09-2021(online)].pdf | 2021-09-15 |
| 7 | 201741013739-IntimationOfGrant18-12-2024.pdf | 2024-12-18 |
| 8 | 201741013739-COMPLETE SPECIFICATION [09-03-2018(online)].pdf | 2018-03-09 |
| 8 | 201741013739-FORM 4 [20-08-2021(online)].pdf | 2021-08-20 |
| 8 | 201741013739-PatentCertificate18-12-2024.pdf | 2024-12-18 |
| 8 | 201741013739-ReviewPetition-HearingNotice-(HearingDate-28-10-2024).pdf | 2024-09-26 |
| 8 | 201741013739-US(14)-HearingNotice-(HearingDate-11-06-2021).pdf | 2021-10-17 |
| 9 | 201741013739-FER.pdf | 2021-10-17 |
| 9 | 201741013739-FORM 3 [09-10-2018(online)].pdf | 2018-10-09 |
| 9 | 201741013739-FORM-24 [17-09-2021(online)].pdf | 2021-09-17 |
| 9 | 201741013739-Response to office action [03-12-2024(online)].pdf | 2024-12-03 |
| 9 | 201741013739-Written submissions and relevant documents [26-06-2021(online)].pdf | 2021-06-26 |
| 10 | 201741013739-Correspondence to notify the Controller [09-06-2021(online)].pdf | 2021-06-09 |
| 10 | 201741013739-FORM-26 [15-09-2021(online)].pdf | 2021-09-15 |
| 10 | 201741013739-RELEVANT DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 10 | 201741013739-US(14)-HearingNotice-(HearingDate-11-06-2021).pdf | 2021-10-17 |
| 10 | 201741013739-Written submissions and relevant documents [12-11-2024(online)].pdf | 2024-11-12 |
| 11 | 201741013739-CLAIMS [27-04-2021(online)].pdf | 2021-04-27 |
| 11 | 201741013739-Correspondence to notify the Controller [25-10-2024(online)].pdf | 2024-10-25 |
| 11 | 201741013739-FORM 3 [09-11-2018(online)].pdf | 2018-11-09 |
| 11 | 201741013739-FORM 4 [20-08-2021(online)].pdf | 2021-08-20 |
| 11 | 201741013739-FORM-24 [17-09-2021(online)].pdf | 2021-09-17 |
| 12 | 201741013739-Written submissions and relevant documents [26-06-2021(online)].pdf | 2021-06-26 |
| 12 | 201741013739-ReviewPetition-HearingNotice-(HearingDate-28-10-2024).pdf | 2024-09-26 |
| 12 | 201741013739-FORM-26 [15-09-2021(online)].pdf | 2021-09-15 |
| 12 | 201741013739-FORM 13 [09-11-2018(online)].pdf | 2018-11-09 |
| 12 | 201741013739-COMPLETE SPECIFICATION [27-04-2021(online)].pdf | 2021-04-27 |
| 13 | 201741013739-AMMENDED DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 13 | 201741013739-Correspondence to notify the Controller [09-06-2021(online)].pdf | 2021-06-09 |
| 13 | 201741013739-DRAWING [27-04-2021(online)].pdf | 2021-04-27 |
| 13 | 201741013739-FER.pdf | 2021-10-17 |
| 13 | 201741013739-FORM 4 [20-08-2021(online)].pdf | 2021-08-20 |
| 14 | 201741013739-CLAIMS [27-04-2021(online)].pdf | 2021-04-27 |
| 14 | 201741013739-FER_SER_REPLY [27-04-2021(online)].pdf | 2021-04-27 |
| 14 | 201741013739-REQUEST FOR CERTIFIED COPY [09-08-2019(online)].pdf | 2019-08-09 |
| 14 | 201741013739-US(14)-HearingNotice-(HearingDate-11-06-2021).pdf | 2021-10-17 |
| 14 | 201741013739-Written submissions and relevant documents [26-06-2021(online)].pdf | 2021-06-26 |
| 15 | 201741013739-COMPLETE SPECIFICATION [27-04-2021(online)].pdf | 2021-04-27 |
| 15 | 201741013739-Correspondence to notify the Controller [09-06-2021(online)].pdf | 2021-06-09 |
| 15 | 201741013739-FORM-24 [17-09-2021(online)].pdf | 2021-09-17 |
| 15 | 201741013739-OTHERS [27-04-2021(online)].pdf | 2021-04-27 |
| 15 | 201741013739-Response to office action (Mandatory) [19-08-2019(online)].pdf | 2019-08-19 |
| 16 | 201741013739-Response to office action (Mandatory) [17-09-2019(online)].pdf | 2019-09-17 |
| 16 | 201741013739-FORM-26 [15-09-2021(online)].pdf | 2021-09-15 |
| 16 | 201741013739-FORM 18 [15-10-2019(online)].pdf | 2019-10-15 |
| 16 | 201741013739-DRAWING [27-04-2021(online)].pdf | 2021-04-27 |
| 16 | 201741013739-CLAIMS [27-04-2021(online)].pdf | 2021-04-27 |
| 17 | 201741013739-Response to office action (Mandatory) [17-09-2019(online)].pdf | 2019-09-17 |
| 17 | 201741013739-FORM 4 [20-08-2021(online)].pdf | 2021-08-20 |
| 17 | 201741013739-FORM 18 [15-10-2019(online)].pdf | 2019-10-15 |
| 17 | 201741013739-FER_SER_REPLY [27-04-2021(online)].pdf | 2021-04-27 |
| 17 | 201741013739-COMPLETE SPECIFICATION [27-04-2021(online)].pdf | 2021-04-27 |
| 18 | 201741013739-DRAWING [27-04-2021(online)].pdf | 2021-04-27 |
| 18 | 201741013739-OTHERS [27-04-2021(online)].pdf | 2021-04-27 |
| 18 | 201741013739-Response to office action (Mandatory) [19-08-2019(online)].pdf | 2019-08-19 |
| 18 | 201741013739-Written submissions and relevant documents [26-06-2021(online)].pdf | 2021-06-26 |
| 19 | 201741013739-Correspondence to notify the Controller [09-06-2021(online)].pdf | 2021-06-09 |
| 19 | 201741013739-FER_SER_REPLY [27-04-2021(online)].pdf | 2021-04-27 |
| 19 | 201741013739-FORM 18 [15-10-2019(online)].pdf | 2019-10-15 |
| 19 | 201741013739-REQUEST FOR CERTIFIED COPY [09-08-2019(online)].pdf | 2019-08-09 |
| 20 | 201741013739-AMMENDED DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 20 | 201741013739-CLAIMS [27-04-2021(online)].pdf | 2021-04-27 |
| 20 | 201741013739-DRAWING [27-04-2021(online)].pdf | 2021-04-27 |
| 20 | 201741013739-OTHERS [27-04-2021(online)].pdf | 2021-04-27 |
| 20 | 201741013739-Response to office action (Mandatory) [17-09-2019(online)].pdf | 2019-09-17 |
| 21 | 201741013739-Response to office action (Mandatory) [19-08-2019(online)].pdf | 2019-08-19 |
| 21 | 201741013739-FORM 18 [15-10-2019(online)].pdf | 2019-10-15 |
| 21 | 201741013739-FORM 13 [09-11-2018(online)].pdf | 2018-11-09 |
| 21 | 201741013739-COMPLETE SPECIFICATION [27-04-2021(online)].pdf | 2021-04-27 |
| 22 | 201741013739-CLAIMS [27-04-2021(online)].pdf | 2021-04-27 |
| 22 | 201741013739-DRAWING [27-04-2021(online)].pdf | 2021-04-27 |
| 22 | 201741013739-FORM 3 [09-11-2018(online)].pdf | 2018-11-09 |
| 22 | 201741013739-REQUEST FOR CERTIFIED COPY [09-08-2019(online)].pdf | 2019-08-09 |
| 22 | 201741013739-Response to office action (Mandatory) [17-09-2019(online)].pdf | 2019-09-17 |
| 23 | 201741013739-Response to office action (Mandatory) [19-08-2019(online)].pdf | 2019-08-19 |
| 23 | 201741013739-RELEVANT DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 23 | 201741013739-FER_SER_REPLY [27-04-2021(online)].pdf | 2021-04-27 |
| 23 | 201741013739-Correspondence to notify the Controller [09-06-2021(online)].pdf | 2021-06-09 |
| 23 | 201741013739-AMMENDED DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 24 | 201741013739-Written submissions and relevant documents [26-06-2021(online)].pdf | 2021-06-26 |
| 24 | 201741013739-REQUEST FOR CERTIFIED COPY [09-08-2019(online)].pdf | 2019-08-09 |
| 24 | 201741013739-FORM 13 [09-11-2018(online)].pdf | 2018-11-09 |
| 24 | 201741013739-FORM 3 [09-10-2018(online)].pdf | 2018-10-09 |
| 24 | 201741013739-OTHERS [27-04-2021(online)].pdf | 2021-04-27 |
| 25 | 201741013739-FORM 3 [09-11-2018(online)].pdf | 2018-11-09 |
| 25 | 201741013739-FORM 4 [20-08-2021(online)].pdf | 2021-08-20 |
| 25 | 201741013739-AMMENDED DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 25 | 201741013739-COMPLETE SPECIFICATION [09-03-2018(online)].pdf | 2018-03-09 |
| 25 | 201741013739-FORM 18 [15-10-2019(online)].pdf | 2019-10-15 |
| 26 | 201741013739-DRAWING [09-03-2018(online)].pdf | 2018-03-09 |
| 26 | 201741013739-FORM 13 [09-11-2018(online)].pdf | 2018-11-09 |
| 26 | 201741013739-FORM-26 [15-09-2021(online)].pdf | 2021-09-15 |
| 26 | 201741013739-RELEVANT DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 26 | 201741013739-Response to office action (Mandatory) [17-09-2019(online)].pdf | 2019-09-17 |
| 27 | 201741013739-ENDORSEMENT BY INVENTORS [09-03-2018(online)].pdf | 2018-03-09 |
| 27 | 201741013739-FORM 3 [09-10-2018(online)].pdf | 2018-10-09 |
| 27 | 201741013739-FORM 3 [09-11-2018(online)].pdf | 2018-11-09 |
| 27 | 201741013739-FORM-24 [17-09-2021(online)].pdf | 2021-09-17 |
| 27 | 201741013739-Response to office action (Mandatory) [19-08-2019(online)].pdf | 2019-08-19 |
| 28 | 201741013739-US(14)-HearingNotice-(HearingDate-11-06-2021).pdf | 2021-10-17 |
| 28 | 201741013739-REQUEST FOR CERTIFIED COPY [09-08-2019(online)].pdf | 2019-08-09 |
| 28 | 201741013739-RELEVANT DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 28 | 201741013739-Proof of Right (MANDATORY) [02-11-2017(online)].pdf | 2017-11-02 |
| 28 | 201741013739-COMPLETE SPECIFICATION [09-03-2018(online)].pdf | 2018-03-09 |
| 29 | 201741013739-AMMENDED DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 29 | 201741013739-DRAWING [09-03-2018(online)].pdf | 2018-03-09 |
| 29 | 201741013739-FER.pdf | 2021-10-17 |
| 29 | 201741013739-FORM 3 [09-10-2018(online)].pdf | 2018-10-09 |
| 29 | Correspondence by Agent_Power of Attorney_04-10-2017.pdf | 2017-10-04 |
| 30 | 201741013739-COMPLETE SPECIFICATION [09-03-2018(online)].pdf | 2018-03-09 |
| 30 | 201741013739-ENDORSEMENT BY INVENTORS [09-03-2018(online)].pdf | 2018-03-09 |
| 30 | 201741013739-FORM 13 [09-11-2018(online)].pdf | 2018-11-09 |
| 30 | 201741013739-FORM-26 [27-09-2017(online)].pdf | 2017-09-27 |
| 30 | 201741013739-ReviewPetition-HearingNotice-(HearingDate-28-10-2024).pdf | 2024-09-26 |
| 31 | 201741013739-Correspondence to notify the Controller [25-10-2024(online)].pdf | 2024-10-25 |
| 31 | 201741013739-DRAWING [09-03-2018(online)].pdf | 2018-03-09 |
| 31 | 201741013739-FORM 3 [09-11-2018(online)].pdf | 2018-11-09 |
| 31 | 201741013739-Proof of Right (MANDATORY) [02-11-2017(online)].pdf | 2017-11-02 |
| 31 | Description(Provisional) [18-04-2017(online)].pdf | 2017-04-18 |
| 32 | Form 3 [18-04-2017(online)].pdf | 2017-04-18 |
| 32 | Correspondence by Agent_Power of Attorney_04-10-2017.pdf | 2017-10-04 |
| 32 | 201741013739-Written submissions and relevant documents [12-11-2024(online)].pdf | 2024-11-12 |
| 32 | 201741013739-RELEVANT DOCUMENTS [09-11-2018(online)].pdf | 2018-11-09 |
| 32 | 201741013739-ENDORSEMENT BY INVENTORS [09-03-2018(online)].pdf | 2018-03-09 |
| 33 | 201741013739-FORM 3 [09-10-2018(online)].pdf | 2018-10-09 |
| 33 | 201741013739-FORM-26 [27-09-2017(online)].pdf | 2017-09-27 |
| 33 | 201741013739-Proof of Right (MANDATORY) [02-11-2017(online)].pdf | 2017-11-02 |
| 33 | 201741013739-Response to office action [03-12-2024(online)].pdf | 2024-12-03 |
| 34 | 201741013739-COMPLETE SPECIFICATION [09-03-2018(online)].pdf | 2018-03-09 |
| 34 | 201741013739-PatentCertificate18-12-2024.pdf | 2024-12-18 |
| 34 | Correspondence by Agent_Power of Attorney_04-10-2017.pdf | 2017-10-04 |
| 34 | Description(Provisional) [18-04-2017(online)].pdf | 2017-04-18 |
| 35 | 201741013739-DRAWING [09-03-2018(online)].pdf | 2018-03-09 |
| 35 | 201741013739-FORM-26 [27-09-2017(online)].pdf | 2017-09-27 |
| 35 | 201741013739-IntimationOfGrant18-12-2024.pdf | 2024-12-18 |
| 35 | Form 3 [18-04-2017(online)].pdf | 2017-04-18 |
| 36 | 201741013739-ENDORSEMENT BY INVENTORS [09-03-2018(online)].pdf | 2018-03-09 |
| 36 | 201741013739-EVIDENCE FOR REGISTRATION UNDER SSI [07-03-2025(online)].pdf | 2025-03-07 |
| 36 | Description(Provisional) [18-04-2017(online)].pdf | 2017-04-18 |
| 37 | 201741013739-EDUCATIONAL INSTITUTION(S) [07-03-2025(online)].pdf | 2025-03-07 |
| 37 | 201741013739-Proof of Right (MANDATORY) [02-11-2017(online)].pdf | 2017-11-02 |
| 37 | Form 3 [18-04-2017(online)].pdf | 2017-04-18 |
| 38 | 201741013739- Certificate of Inventorship-044000213( 19-03-2025 ).pdf | 2025-03-19 |
| 38 | Correspondence by Agent_Power of Attorney_04-10-2017.pdf | 2017-10-04 |
| 39 | 201741013739- Certificate of Inventorship-044000212( 19-03-2025 ).pdf | 2025-03-19 |
| 39 | 201741013739-FORM-26 [27-09-2017(online)].pdf | 2017-09-27 |
| 40 | Description(Provisional) [18-04-2017(online)].pdf | 2017-04-18 |
| 41 | Form 3 [18-04-2017(online)].pdf | 2017-04-18 |
Search Strategy
| 1 | 2020-10-2712-59-03E_27-10-2020.pdf |