"Il 18 Binding Proteins"

Abstract: The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for delecting hIL-18 and for inhibiting hIL-18 activity. e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

Patent Information

Application #

Filing Date

23 November 2010

Publication Number

09/2012

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

ABBOTT LABORATORIES

D-377 AP6A/1, 100 ABBOT PARK ROAD, ABBOTT PARK, IL 60064 U.S.A.

Inventors

1. GHAYUR TARIQ

1014 WASHINGTON STREET, HOLLISTON, MASSACHUSETTS 01746 U.S.A.

2. LABKOVSKY BORIS

107A-5 BROADMEADOW ROAD, MARLBOROUGH, MA 01752 U.S.A.

3. VOSS JEFFREY W.

257 SHREWSBURY STREET, HOLDEN, MA 01520 U.S.A.

4. GREEN LARRY

464 HILL STREET, SAN FRANCISCO, CA 94114 U.S.A.

5. BABCOOK JOHN

4480 W. 12TH AVENUE, VANCOUVER, BRITISH COLUMBIA V6R 2R2 CANADA.

6. JIA XIAO-CHI

2262 S. BEVERLY DRIVE, LOS ANGELES, CA 90034 U.S.A.

7. WIELER JAMES

508 BROUGHTON DRIVE, BEVERLY, MA 01915 U.S.A.

8. KANG JASPAL SINGH

16727 109 AVENUE, SURREY, BRITISH COLUMBIA V4N 5H6 CANADA.

9. HEDBERG BRAD

#1607-63 KEEFER PLACE, VANCOUVER, BRITISH COLUMBIA V6B 6N6 CANADA.