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"Imaging Neuroinflammation"
Abstract: The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo imaging agent is provided that binds with high affinity to PBR, has good uptake into the brain following administration, and which preferentially binds to tissues expressing higher levels of PBR. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. A cassette for the automated synthesis of the in vivo imaging agent is also provided. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.
Notices, Deadlines & Correspondence
Patent Information
Applicants
GE HEALTHCARE LIMITED
Inventors
1. HARY JOHN WADSWORTH
2. BO SHAN
3. DENNIS O'SHEA
4. JOANNA MARIE PASSMORE
5. WILLIAM JOHN TRIGG
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 2380-DELNP-2011-AbandonedLetter.pdf | 2018-02-01 |
| 1 | 2380-delnp-2011-Form-1-(11-07-2011).pdf | 2011-07-11 |
| 2 | 2380-DELNP-2011-FER.pdf | 2017-05-31 |
| 2 | 2380-delnp-2011-Correspodence Others-(11-07-2011).pdf | 2011-07-11 |
| 3 | 2380-delnp-2011-Form-5.pdf | 2011-10-05 |
| 3 | 2380-delnp-2011-Correspondence-Others-(02-07-2014).pdf | 2014-07-02 |
| 4 | 2380-delnp-2011-Form-3.pdf | 2011-10-05 |
| 4 | 2380-delnp-2011-Form-3-(02-07-2014).pdf | 2014-07-02 |
| 5 | 2380-delnp-2011-Form-2.pdf | 2011-10-05 |
| 5 | 2380-delnp-2011-Correspondence Others-(04-03-2013).pdf | 2013-03-04 |
| 6 | 2380-delnp-2011-Form-1.pdf | 2011-10-05 |
| 6 | 2380-delnp-2011-Correspondence Others-(11-09-2012).pdf | 2012-09-11 |
| 7 | 2380-delnp-2011-Form-18-(11-09-2012).pdf | 2012-09-11 |
| 7 | 2380-delnp-2011-Drawings.pdf | 2011-10-05 |
| 8 | 2380-delnp-2011-Description (Complete).pdf | 2011-10-05 |
| 8 | 2380-delnp-2011-Correspondence others-(15-03-2012).pdf | 2012-03-15 |
| 9 | 2380-delnp-2011-Form-3 (15-03-2012).pdf | 2012-03-15 |
| 9 | 2380-delnp-2011-Correspondence Others.pdf | 2011-10-05 |
| 10 | 2380-delnp-2011-Claims.pdf | 2011-10-05 |
| 10 | 2380-DELNP-2011-Correspondence Others-(11-10-2011).pdf | 2011-10-11 |
| 11 | 2380-delnp-2011-Abstract.pdf | 2011-10-05 |
| 11 | 2380-DELNP-2011-Form-3-(11-10-2011).pdf | 2011-10-11 |
| 12 | 2380-delnp-2011-Abstract.pdf | 2011-10-05 |
| 12 | 2380-DELNP-2011-Form-3-(11-10-2011).pdf | 2011-10-11 |
| 13 | 2380-delnp-2011-Claims.pdf | 2011-10-05 |
| 13 | 2380-DELNP-2011-Correspondence Others-(11-10-2011).pdf | 2011-10-11 |
| 14 | 2380-delnp-2011-Correspondence Others.pdf | 2011-10-05 |
| 14 | 2380-delnp-2011-Form-3 (15-03-2012).pdf | 2012-03-15 |
| 15 | 2380-delnp-2011-Correspondence others-(15-03-2012).pdf | 2012-03-15 |
| 15 | 2380-delnp-2011-Description (Complete).pdf | 2011-10-05 |
| 16 | 2380-delnp-2011-Drawings.pdf | 2011-10-05 |
| 16 | 2380-delnp-2011-Form-18-(11-09-2012).pdf | 2012-09-11 |
| 17 | 2380-delnp-2011-Correspondence Others-(11-09-2012).pdf | 2012-09-11 |
| 17 | 2380-delnp-2011-Form-1.pdf | 2011-10-05 |
| 18 | 2380-delnp-2011-Correspondence Others-(04-03-2013).pdf | 2013-03-04 |
| 18 | 2380-delnp-2011-Form-2.pdf | 2011-10-05 |
| 19 | 2380-delnp-2011-Form-3.pdf | 2011-10-05 |
| 19 | 2380-delnp-2011-Form-3-(02-07-2014).pdf | 2014-07-02 |
| 20 | 2380-delnp-2011-Form-5.pdf | 2011-10-05 |
| 20 | 2380-delnp-2011-Correspondence-Others-(02-07-2014).pdf | 2014-07-02 |
| 21 | 2380-DELNP-2011-FER.pdf | 2017-05-31 |
| 21 | 2380-delnp-2011-Correspodence Others-(11-07-2011).pdf | 2011-07-11 |
| 22 | 2380-delnp-2011-Form-1-(11-07-2011).pdf | 2011-07-11 |
| 22 | 2380-DELNP-2011-AbandonedLetter.pdf | 2018-02-01 |
Search Strategy
| 1 | searchstrategy_25-05-2017.pdf |