Abstract: The purpose of the present invention is to provide an adsorption material capable of selectively adsorbing immunosuppressive leukocytes. The present disclosure provides an immunosuppressive leukocyte adsorption material containing a water-insoluble carrier to which is bonded one or more nitrogen-containing compounds selected from polyamines represented by a prescribed formula and aliphatic amines represented by a prescribed formula, the water-insoluble carrier having the form of fibers or particles, the diameter of the fibers or the particles being 15-50 µm, and the arithmetic mean roughness of the surface of the water-insoluble carrier being 0.1-3.0 µm.
WE CLAIM:
[Claim 1]
An adsorption material for immunosuppressive leukocyte, the adsorption material comprising
a water-insoluble carrier to which at least one nitrogen-containing compound is bound, the nitrogen-containing compound being selected from a polyamine represented by following Formula (1), a primary aliphatic amine represented by following Formula (2), and a secondary aliphatic amine represented by Formula (3),
wherein the water-insoluble carrier has a form of fiber or particle, the fiber or the particle has a diameter of 15 to 50 um, and the water-insoluble carrier has a surface with an arithmetic mean roughness of 0.1 to 3.0 um:
R1R2N-X-NR3R4 … Formula (1)
in Formula (1), X is a saturated or unsaturated aliphatic hydrocarbon group having 2 to 20 carbon atoms, or a heteroatom-containing carbon chain in which 1 to 5 carbon atoms of a saturated or unsaturated aliphatic hydrocarbon group having 3 to 20 carbon atoms are replaced with a nitrogen atom, a hydrogen atom that bonds to the nitrogen atom may be replaced with an alkyl group that may have an amino group, and R1 to R4 are each independently a hydrogen atom or an alkyl group;
NH2R5 … Formula (2)
in Formula (2), R5 is a saturated or unsaturated aliphatic hydrocarbon group having 1 to 12 carbon atoms;
NHR6R7 … Formula (3)
in Formula (3), R6 and R7 are each independently a saturated or unsaturated aliphatic hydrocarbon group having 1 to 12 carbon atoms.
[Claim 2]
The adsorption material according to claim 1,
wherein the nitrogen-containing compound comprises the polyamine represented by the Formula (1).
[Claim 3]
The adsorption material according to claim 1 or 2,
wherein the nitrogen-containing compound binds to the water-insoluble carrier via a linker.
[Claim 4]
The adsorption material according to any one of claims 1 to 3, wherein the water-insoluble carrier has a form of fiber.
[Claim 5]
The adsorption material according to any one of claims 1 to 4,
wherein the immunosuppressive leukocyte is a LAP positive lymphocyte
or a LAP positive monocyte.
[Claim 6]
An adsorption column comprising the adsorption material according to any one of claims 1 to 5.
[Claim 7]
The adsorption column according to claim 6,
wherein the adsorption column is used for a blood purification therapy.
| # | Name | Date |
|---|---|---|
| 1 | 202047006010-FORM 3 [05-08-2020(online)].pdf | 2020-08-05 |
| 1 | 202047006010.pdf | 2020-02-12 |
| 2 | 202047006010-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [12-02-2020(online)].pdf | 2020-02-12 |
| 2 | 202047006010-Correspondence_26-02-2020.pdf | 2020-02-26 |
| 3 | 202047006010-STATEMENT OF UNDERTAKING (FORM 3) [12-02-2020(online)].pdf | 2020-02-12 |
| 3 | 202047006010-Form1_(Proof of Right)_26-02-2020.pdf | 2020-02-26 |
| 4 | 202047006010-PROOF OF RIGHT [12-02-2020(online)].pdf | 2020-02-12 |
| 4 | 202047006010-Form26_General Power of Attorney_26-02-2020.pdf | 2020-02-26 |
| 5 | 202047006010-PRIORITY DOCUMENTS [12-02-2020(online)].pdf | 2020-02-12 |
| 5 | 202047006010-FORM-26 [18-02-2020(online)].pdf | 2020-02-18 |
| 6 | 202047006010-FORM 1 [12-02-2020(online)].pdf | 2020-02-12 |
| 6 | 202047006010-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [12-02-2020(online)].pdf | 2020-02-12 |
| 7 | 202047006010-DRAWINGS [12-02-2020(online)].pdf | 2020-02-12 |
| 7 | 202047006010-COMPLETE SPECIFICATION [12-02-2020(online)].pdf | 2020-02-12 |
| 8 | 202047006010-DECLARATION OF INVENTORSHIP (FORM 5) [12-02-2020(online)].pdf | 2020-02-12 |
| 9 | 202047006010-DRAWINGS [12-02-2020(online)].pdf | 2020-02-12 |
| 9 | 202047006010-COMPLETE SPECIFICATION [12-02-2020(online)].pdf | 2020-02-12 |
| 10 | 202047006010-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [12-02-2020(online)].pdf | 2020-02-12 |
| 10 | 202047006010-FORM 1 [12-02-2020(online)].pdf | 2020-02-12 |
| 11 | 202047006010-PRIORITY DOCUMENTS [12-02-2020(online)].pdf | 2020-02-12 |
| 11 | 202047006010-FORM-26 [18-02-2020(online)].pdf | 2020-02-18 |
| 12 | 202047006010-PROOF OF RIGHT [12-02-2020(online)].pdf | 2020-02-12 |
| 12 | 202047006010-Form26_General Power of Attorney_26-02-2020.pdf | 2020-02-26 |
| 13 | 202047006010-STATEMENT OF UNDERTAKING (FORM 3) [12-02-2020(online)].pdf | 2020-02-12 |
| 13 | 202047006010-Form1_(Proof of Right)_26-02-2020.pdf | 2020-02-26 |
| 14 | 202047006010-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [12-02-2020(online)].pdf | 2020-02-12 |
| 14 | 202047006010-Correspondence_26-02-2020.pdf | 2020-02-26 |
| 15 | 202047006010.pdf | 2020-02-12 |
| 15 | 202047006010-FORM 3 [05-08-2020(online)].pdf | 2020-08-05 |