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Immunosuppressive Leukocyte Adsorption Material And Adsorption Column

Abstract: The purpose of the present invention is to provide an adsorption material capable of selectively adsorbing immunosuppressive leukocytes. The present disclosure provides an immunosuppressive leukocyte adsorption material containing a water-insoluble carrier to which is bonded one or more nitrogen-containing compounds selected from polyamines represented by a prescribed formula and aliphatic amines represented by a prescribed formula, the water-insoluble carrier having the form of fibers or particles, the diameter of the fibers or the particles being 15-50 µm, and the arithmetic mean roughness of the surface of the water-insoluble carrier being 0.1-3.0 µm.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
12 February 2020
Publication Number
11/2020
Publication Type
INA
Invention Field
BIO-MEDICAL ENGINEERING
Status
Email
patent@depenning.com
Parent Application

Applicants

TORAY INDUSTRIES, INC.
1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 103-8666
NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
Seta Tsukinowa-cho, Otsu-shi, Shiga 520-2192

Inventors

1. UENO, Yoshiyuki
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
2. KASUYA ,Junichi
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
3. ARAKANE, Toru
c/o Tokyo Head Office, Toray Industries, Inc., 1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 103-8666
4. MATSUNAGA, Ryo
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
5. SEKIYA, Yumiko
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 520-8558
6. UEDA, Yuji
2-22, Matsuzaki-cho 1-chome, Abeno-ku, Osaka-shi, Osaka 545-0053
7. TERAMOTO, Kazuo
c/o National University Corporation Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu-shi, Shiga 520-2192
8. OGASAWARA, Kazumasa
c/o National University Corporation Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu-shi, Shiga 520-2192

Specification

WE CLAIM:
[Claim 1]
An adsorption material for immunosuppressive leukocyte, the adsorption material comprising
a water-insoluble carrier to which at least one nitrogen-containing compound is bound, the nitrogen-containing compound being selected from a polyamine represented by following Formula (1), a primary aliphatic amine represented by following Formula (2), and a secondary aliphatic amine represented by Formula (3),
wherein the water-insoluble carrier has a form of fiber or particle, the fiber or the particle has a diameter of 15 to 50 um, and the water-insoluble carrier has a surface with an arithmetic mean roughness of 0.1 to 3.0 um:
R1R2N-X-NR3R4 … Formula (1)
in Formula (1), X is a saturated or unsaturated aliphatic hydrocarbon group having 2 to 20 carbon atoms, or a heteroatom-containing carbon chain in which 1 to 5 carbon atoms of a saturated or unsaturated aliphatic hydrocarbon group having 3 to 20 carbon atoms are replaced with a nitrogen atom, a hydrogen atom that bonds to the nitrogen atom may be replaced with an alkyl group that may have an amino group, and R1 to R4 are each independently a hydrogen atom or an alkyl group;
NH2R5 … Formula (2)
in Formula (2), R5 is a saturated or unsaturated aliphatic hydrocarbon group having 1 to 12 carbon atoms;
NHR6R7 … Formula (3)
in Formula (3), R6 and R7 are each independently a saturated or unsaturated aliphatic hydrocarbon group having 1 to 12 carbon atoms.
[Claim 2]

The adsorption material according to claim 1,
wherein the nitrogen-containing compound comprises the polyamine represented by the Formula (1).
[Claim 3]
The adsorption material according to claim 1 or 2,
wherein the nitrogen-containing compound binds to the water-insoluble carrier via a linker.
[Claim 4]
The adsorption material according to any one of claims 1 to 3, wherein the water-insoluble carrier has a form of fiber.
[Claim 5]
The adsorption material according to any one of claims 1 to 4,
wherein the immunosuppressive leukocyte is a LAP positive lymphocyte
or a LAP positive monocyte.
[Claim 6]
An adsorption column comprising the adsorption material according to any one of claims 1 to 5.
[Claim 7]
The adsorption column according to claim 6,
wherein the adsorption column is used for a blood purification therapy.

Documents

Application Documents

# Name Date
1 202047006010-FORM 3 [05-08-2020(online)].pdf 2020-08-05
1 202047006010.pdf 2020-02-12
2 202047006010-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [12-02-2020(online)].pdf 2020-02-12
2 202047006010-Correspondence_26-02-2020.pdf 2020-02-26
3 202047006010-STATEMENT OF UNDERTAKING (FORM 3) [12-02-2020(online)].pdf 2020-02-12
3 202047006010-Form1_(Proof of Right)_26-02-2020.pdf 2020-02-26
4 202047006010-PROOF OF RIGHT [12-02-2020(online)].pdf 2020-02-12
4 202047006010-Form26_General Power of Attorney_26-02-2020.pdf 2020-02-26
5 202047006010-PRIORITY DOCUMENTS [12-02-2020(online)].pdf 2020-02-12
5 202047006010-FORM-26 [18-02-2020(online)].pdf 2020-02-18
6 202047006010-FORM 1 [12-02-2020(online)].pdf 2020-02-12
6 202047006010-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [12-02-2020(online)].pdf 2020-02-12
7 202047006010-DRAWINGS [12-02-2020(online)].pdf 2020-02-12
7 202047006010-COMPLETE SPECIFICATION [12-02-2020(online)].pdf 2020-02-12
8 202047006010-DECLARATION OF INVENTORSHIP (FORM 5) [12-02-2020(online)].pdf 2020-02-12
9 202047006010-DRAWINGS [12-02-2020(online)].pdf 2020-02-12
9 202047006010-COMPLETE SPECIFICATION [12-02-2020(online)].pdf 2020-02-12
10 202047006010-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [12-02-2020(online)].pdf 2020-02-12
10 202047006010-FORM 1 [12-02-2020(online)].pdf 2020-02-12
11 202047006010-PRIORITY DOCUMENTS [12-02-2020(online)].pdf 2020-02-12
11 202047006010-FORM-26 [18-02-2020(online)].pdf 2020-02-18
12 202047006010-PROOF OF RIGHT [12-02-2020(online)].pdf 2020-02-12
12 202047006010-Form26_General Power of Attorney_26-02-2020.pdf 2020-02-26
13 202047006010-STATEMENT OF UNDERTAKING (FORM 3) [12-02-2020(online)].pdf 2020-02-12
13 202047006010-Form1_(Proof of Right)_26-02-2020.pdf 2020-02-26
14 202047006010-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [12-02-2020(online)].pdf 2020-02-12
14 202047006010-Correspondence_26-02-2020.pdf 2020-02-26
15 202047006010.pdf 2020-02-12
15 202047006010-FORM 3 [05-08-2020(online)].pdf 2020-08-05