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Inhibitors Of Cytosolic Phospholipase A2
Abstract: This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2α). In some embodiments, the inhibitors have the Formula (I): wherein the constituent variables are as defined herein.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
26 November 2007
Publication Number
23/2008
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2014-07-28
Renewal Date
Applicants
WYETH
FIVE GIRALDA FARMS, MADISON, NEW JERSEY
Inventors
1. MCKEW JOHN C
56 VARNUM STREET, ARLINGTON, MA 02140
2. LEE KATHERINE L
167 ADAMS AVENUE, NEWTON, MA 02465
3. CHEN LILHREN
129 PAGE ROAD, BEDFORD, MA 01730
4. VARGAS RICHARD
523 WASHINGTON STREET, BRIGHTON, MA 02135
5. CLARK JAMES D
2 BRIMSTON LANE, ACTON, MA 01720
6. WILLIAMS CARA
11 OBSERVATORY ROAD, METHUEN, MA 01844
7. CLERIN VALERIE
32 HARDY AVENUE, WATERTOWN, MA 02472
8. MARUSIC SUZANA
70 DIVIDENCE ROAD, READING MA 01867
9. PONG KEVIN
61 ELDRIDGE DRIVE, ROBBINSVILLE, NJ 08691
Specification
(54) Title: INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2
(57) Abstract: This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic
phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLAα).
In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 4549-KOLNP-2007-PCT PRIORITY DOCUMENT NOTIFICATION.pdf | 2011-10-08 |
| 1 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [14-09-2022(online)].pdf | 2022-09-14 |
| 2 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [23-08-2022(online)].pdf | 2022-08-23 |
| 2 | 4549-KOLNP-2007-FORM 3.1.pdf | 2011-10-08 |
| 3 | 4549-KOLNP-2007-FORM 3-1.1.pdf | 2011-10-08 |
| 3 | 4549-KOLNP-2007-ASSIGNMENT WITH VERIFIED COPY [12-04-2022(online)].pdf | 2022-04-12 |
| 4 | 4549-KOLNP-2007-FORM-16 [12-04-2022(online)].pdf | 2022-04-12 |
| 4 | 4549-kolnp-2007-form 18.pdf | 2011-10-08 |
| 5 | 4549-KOLNP-2007-POWER OF AUTHORITY [12-04-2022(online)].pdf | 2022-04-12 |
| 5 | 4549-KOLNP-2007-CORRESPONDENCE OTHERS 1.1.pdf | 2011-10-08 |
| 6 | 4549-KOLNP-2007-CORRESPONDENCE 1.3.pdf | 2011-10-08 |
| 6 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [09-10-2021(online)].pdf | 2021-10-09 |
| 7 | 4549-KOLNP-2007-CORRESPONDENCE 1.2.pdf | 2011-10-08 |
| 7 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [29-09-2021(online)].pdf | 2021-09-29 |
| 8 | 04549-kolnp-2007-international search report.pdf | 2011-10-08 |
| 8 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [20-03-2020(online)].pdf | 2020-03-20 |
| 9 | 04549-kolnp-2007-international publication.pdf | 2011-10-08 |
| 9 | 4549-KOLNP-2007-FORM-26 [23-09-2019(online)].pdf | 2019-09-23 |
| 10 | 04549-kolnp-2007-gpa.pdf | 2011-10-08 |
| 10 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [25-03-2019(online)].pdf | 2019-03-25 |
| 11 | 04549-kolnp-2007-form 5.pdf | 2011-10-08 |
| 11 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [01-02-2019(online)].pdf | 2019-02-01 |
| 12 | 04549-kolnp-2007-form 3.pdf | 2011-10-08 |
| 12 | 4549-KOLNP-2007-Response to office action (Mandatory) [25-01-2019(online)].pdf | 2019-01-25 |
| 13 | 04549-kolnp-2007-form 1.pdf | 2011-10-08 |
| 13 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [30-03-2018(online)].pdf | 2018-03-30 |
| 14 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [13-01-2018(online)].pdf | 2018-01-13 |
| 14 | 04549-kolnp-2007-drawings.pdf | 2011-10-08 |
| 15 | 04549-kolnp-2007-description complete.pdf | 2011-10-08 |
| 15 | Assignment [27-04-2017(online)].pdf | 2017-04-27 |
| 16 | 04549-kolnp-2007-correspondence others.pdf | 2011-10-08 |
| 16 | Form 16 [27-04-2017(online)].pdf | 2017-04-27 |
| 17 | 04549-kolnp-2007-claims.pdf | 2011-10-08 |
| 17 | Other Document [27-04-2017(online)].pdf | 2017-04-27 |
| 18 | 04549-kolnp-2007-abstract.pdf | 2011-10-08 |
| 18 | Power of Attorney [27-04-2017(online)].pdf | 2017-04-27 |
| 19 | 4549-KOLNP-2007-(20-11-2012)-PETITION UNDER RULE 137.pdf | 2012-11-20 |
| 19 | Form 27 [23-03-2017(online)].pdf | 2017-03-23 |
| 20 | 4549-KOLNP-2007-(20-11-2012)-OTHERS.pdf | 2012-11-20 |
| 20 | Form 27 [21-03-2017(online)].pdf | 2017-03-21 |
| 21 | 4549-KOLNP-2007-(20-11-2012)-FORM-2.pdf | 2012-11-20 |
| 21 | Form 27 [20-03-2017(online)].pdf | 2017-03-20 |
| 22 | 4549-KOLNP-2007-(20-11-2012)-FORM-13.pdf | 2012-11-20 |
| 22 | 4549-KOLNP-2007_EXAMREPORT.pdf | 2016-06-30 |
| 23 | 4549-KOLNP-2007-(20-11-2012)-FORM-1.pdf | 2012-11-20 |
| 23 | Form 27 [25-04-2016(online)].pdf | 2016-04-25 |
| 24 | 4549-KOLNP-2007-(20-07-2015)-CORRESPONDENCE.pdf | 2015-07-20 |
| 24 | 4549-KOLNP-2007-(20-11-2012)-DRAWINGS.pdf | 2012-11-20 |
| 25 | 4549-KOLNP-2007-(20-07-2015)-PA.pdf | 2015-07-20 |
| 25 | 4549-KOLNP-2007-(20-11-2012)-DESCRIPTION (COMPLETE).pdf | 2012-11-20 |
| 26 | 262016.pdf | 2015-05-12 |
| 26 | 4549-KOLNP-2007-(20-11-2012)-CORRESPONDENCE.pdf | 2012-11-20 |
| 27 | 4549-KOLNP-2007-(20-11-2012)-CLAIMS.pdf | 2012-11-20 |
| 27 | 4549-KOLNP-2007-AFFIDAVIT.pdf | 2014-08-11 |
| 28 | 4549-KOLNP-2007-CANCELLED PAGES.pdf | 2014-08-11 |
| 28 | 4549-KOLNP-2007-(20-11-2012)-ABSTRACT.pdf | 2012-11-20 |
| 29 | 4549-KOLNP-2007-(22-11-2012)-CORRESPONDENCE.pdf | 2012-11-22 |
| 29 | 4549-KOLNP-2007-CORRESPONDENCE.pdf | 2014-08-11 |
| 30 | 4549-KOLNP-2007-(22-11-2012)-ANNEXURE TO FORM 3.pdf | 2012-11-22 |
| 30 | 4549-KOLNP-2007-EXAMINATION REPORT.pdf | 2014-08-11 |
| 31 | 4549-KOLNP-2007-(03-12-2012)-PETITION UNDER RULE 137.pdf | 2012-12-03 |
| 31 | 4549-KOLNP-2007-FORM 13.pdf | 2014-08-11 |
| 32 | 4549-KOLNP-2007-(03-12-2012)-CORRESPONDENCE.pdf | 2012-12-03 |
| 32 | 4549-KOLNP-2007-FORM 18-1.1.pdf | 2014-08-11 |
| 33 | 4549-KOLNP-2007-(03-12-2012)-ANNEXURE TO FORM 3.pdf | 2012-12-03 |
| 33 | 4549-KOLNP-2007-GPA.pdf | 2014-08-11 |
| 34 | 4549-KOLNP-2007-GRANTED-ABSTRACT.pdf | 2014-08-11 |
| 34 | 4549-KOLNP-2007-ASSIGNMENT.pdf | 2013-04-03 |
| 35 | 4549-KOLNP-2007-(17-04-2013)-OTHERS.pdf | 2013-04-17 |
| 35 | 4549-KOLNP-2007-GRANTED-CLAIMS.pdf | 2014-08-11 |
| 36 | 4549-KOLNP-2007-(17-04-2013)-FORM 5.pdf | 2013-04-17 |
| 36 | 4549-KOLNP-2007-GRANTED-DESCRIPTION (COMPLETE).pdf | 2014-08-11 |
| 37 | 4549-KOLNP-2007-(17-04-2013)-FORM 13.pdf | 2013-04-17 |
| 37 | 4549-KOLNP-2007-GRANTED-DRAWINGS.pdf | 2014-08-11 |
| 38 | 4549-KOLNP-2007-(17-04-2013)-FORM 1.pdf | 2013-04-17 |
| 38 | 4549-KOLNP-2007-GRANTED-FORM 1.pdf | 2014-08-11 |
| 39 | 4549-KOLNP-2007-(17-04-2013)-CORRESPONDENCE.pdf | 2013-04-17 |
| 39 | 4549-KOLNP-2007-GRANTED-FORM 2.pdf | 2014-08-11 |
| 40 | 4549-KOLNP-2007-(17-04-2013)-CLAIMS.pdf | 2013-04-17 |
| 40 | 4549-KOLNP-2007-GRANTED-FORM 3.pdf | 2014-08-11 |
| 41 | 4549-KOLNP-2007-(17-04-2013)-ASSIGNMENT.pdf | 2013-04-17 |
| 41 | 4549-KOLNP-2007-GRANTED-FORM 5.pdf | 2014-08-11 |
| 42 | 4549-KOLNP-2007-(11-11-2013)-CORRESPONDENCE.pdf | 2013-11-11 |
| 42 | 4549-KOLNP-2007-GRANTED-LETTER PATENT.pdf | 2014-08-11 |
| 43 | 4549-KOLNP-2007-(11-11-2013)-ANNEXURE TO FORM 3.pdf | 2013-11-11 |
| 43 | 4549-KOLNP-2007-GRANTED-SPECIFICATION-COMPLETE.pdf | 2014-08-11 |
| 44 | 4549-KOLNP-2007-INTERNATIONAL PUBLICATION.pdf | 2014-08-11 |
| 44 | 4549-KOLNP-2007-TRANSLATED COPY OF PRIORITY DOCUMENT.pdf | 2014-08-11 |
| 45 | 4549-KOLNP-2007-REPLY TO EXAMINATION REPORT.pdf | 2014-08-11 |
| 45 | 4549-KOLNP-2007-INTERNATIONAL SEARCH REPORT & OTHERS.pdf | 2014-08-11 |
| 46 | 4549-KOLNP-2007-PETITION UNDER RULE 137.pdf | 2014-08-11 |
| 46 | 4549-KOLNP-2007-OTHERS.pdf | 2014-08-11 |
| 47 | 4549-KOLNP-2007-PETITION UNDER RULE 137.pdf | 2014-08-11 |
| 47 | 4549-KOLNP-2007-OTHERS.pdf | 2014-08-11 |
| 48 | 4549-KOLNP-2007-REPLY TO EXAMINATION REPORT.pdf | 2014-08-11 |
| 48 | 4549-KOLNP-2007-INTERNATIONAL SEARCH REPORT & OTHERS.pdf | 2014-08-11 |
| 49 | 4549-KOLNP-2007-TRANSLATED COPY OF PRIORITY DOCUMENT.pdf | 2014-08-11 |
| 49 | 4549-KOLNP-2007-INTERNATIONAL PUBLICATION.pdf | 2014-08-11 |
| 50 | 4549-KOLNP-2007-(11-11-2013)-ANNEXURE TO FORM 3.pdf | 2013-11-11 |
| 50 | 4549-KOLNP-2007-GRANTED-SPECIFICATION-COMPLETE.pdf | 2014-08-11 |
| 51 | 4549-KOLNP-2007-GRANTED-LETTER PATENT.pdf | 2014-08-11 |
| 51 | 4549-KOLNP-2007-(11-11-2013)-CORRESPONDENCE.pdf | 2013-11-11 |
| 52 | 4549-KOLNP-2007-GRANTED-FORM 5.pdf | 2014-08-11 |
| 52 | 4549-KOLNP-2007-(17-04-2013)-ASSIGNMENT.pdf | 2013-04-17 |
| 53 | 4549-KOLNP-2007-(17-04-2013)-CLAIMS.pdf | 2013-04-17 |
| 53 | 4549-KOLNP-2007-GRANTED-FORM 3.pdf | 2014-08-11 |
| 54 | 4549-KOLNP-2007-(17-04-2013)-CORRESPONDENCE.pdf | 2013-04-17 |
| 54 | 4549-KOLNP-2007-GRANTED-FORM 2.pdf | 2014-08-11 |
| 55 | 4549-KOLNP-2007-(17-04-2013)-FORM 1.pdf | 2013-04-17 |
| 55 | 4549-KOLNP-2007-GRANTED-FORM 1.pdf | 2014-08-11 |
| 56 | 4549-KOLNP-2007-(17-04-2013)-FORM 13.pdf | 2013-04-17 |
| 56 | 4549-KOLNP-2007-GRANTED-DRAWINGS.pdf | 2014-08-11 |
| 57 | 4549-KOLNP-2007-(17-04-2013)-FORM 5.pdf | 2013-04-17 |
| 57 | 4549-KOLNP-2007-GRANTED-DESCRIPTION (COMPLETE).pdf | 2014-08-11 |
| 58 | 4549-KOLNP-2007-GRANTED-CLAIMS.pdf | 2014-08-11 |
| 58 | 4549-KOLNP-2007-(17-04-2013)-OTHERS.pdf | 2013-04-17 |
| 59 | 4549-KOLNP-2007-ASSIGNMENT.pdf | 2013-04-03 |
| 59 | 4549-KOLNP-2007-GRANTED-ABSTRACT.pdf | 2014-08-11 |
| 60 | 4549-KOLNP-2007-(03-12-2012)-ANNEXURE TO FORM 3.pdf | 2012-12-03 |
| 60 | 4549-KOLNP-2007-GPA.pdf | 2014-08-11 |
| 61 | 4549-KOLNP-2007-(03-12-2012)-CORRESPONDENCE.pdf | 2012-12-03 |
| 61 | 4549-KOLNP-2007-FORM 18-1.1.pdf | 2014-08-11 |
| 62 | 4549-KOLNP-2007-(03-12-2012)-PETITION UNDER RULE 137.pdf | 2012-12-03 |
| 62 | 4549-KOLNP-2007-FORM 13.pdf | 2014-08-11 |
| 63 | 4549-KOLNP-2007-(22-11-2012)-ANNEXURE TO FORM 3.pdf | 2012-11-22 |
| 63 | 4549-KOLNP-2007-EXAMINATION REPORT.pdf | 2014-08-11 |
| 64 | 4549-KOLNP-2007-(22-11-2012)-CORRESPONDENCE.pdf | 2012-11-22 |
| 64 | 4549-KOLNP-2007-CORRESPONDENCE.pdf | 2014-08-11 |
| 65 | 4549-KOLNP-2007-(20-11-2012)-ABSTRACT.pdf | 2012-11-20 |
| 65 | 4549-KOLNP-2007-CANCELLED PAGES.pdf | 2014-08-11 |
| 66 | 4549-KOLNP-2007-(20-11-2012)-CLAIMS.pdf | 2012-11-20 |
| 66 | 4549-KOLNP-2007-AFFIDAVIT.pdf | 2014-08-11 |
| 67 | 4549-KOLNP-2007-(20-11-2012)-CORRESPONDENCE.pdf | 2012-11-20 |
| 67 | 262016.pdf | 2015-05-12 |
| 68 | 4549-KOLNP-2007-(20-11-2012)-DESCRIPTION (COMPLETE).pdf | 2012-11-20 |
| 68 | 4549-KOLNP-2007-(20-07-2015)-PA.pdf | 2015-07-20 |
| 69 | 4549-KOLNP-2007-(20-11-2012)-DRAWINGS.pdf | 2012-11-20 |
| 69 | 4549-KOLNP-2007-(20-07-2015)-CORRESPONDENCE.pdf | 2015-07-20 |
| 70 | 4549-KOLNP-2007-(20-11-2012)-FORM-1.pdf | 2012-11-20 |
| 70 | Form 27 [25-04-2016(online)].pdf | 2016-04-25 |
| 71 | 4549-KOLNP-2007-(20-11-2012)-FORM-13.pdf | 2012-11-20 |
| 71 | 4549-KOLNP-2007_EXAMREPORT.pdf | 2016-06-30 |
| 72 | 4549-KOLNP-2007-(20-11-2012)-FORM-2.pdf | 2012-11-20 |
| 72 | Form 27 [20-03-2017(online)].pdf | 2017-03-20 |
| 73 | 4549-KOLNP-2007-(20-11-2012)-OTHERS.pdf | 2012-11-20 |
| 73 | Form 27 [21-03-2017(online)].pdf | 2017-03-21 |
| 74 | Form 27 [23-03-2017(online)].pdf | 2017-03-23 |
| 74 | 4549-KOLNP-2007-(20-11-2012)-PETITION UNDER RULE 137.pdf | 2012-11-20 |
| 75 | 04549-kolnp-2007-abstract.pdf | 2011-10-08 |
| 75 | Power of Attorney [27-04-2017(online)].pdf | 2017-04-27 |
| 76 | Other Document [27-04-2017(online)].pdf | 2017-04-27 |
| 76 | 04549-kolnp-2007-claims.pdf | 2011-10-08 |
| 77 | Form 16 [27-04-2017(online)].pdf | 2017-04-27 |
| 77 | 04549-kolnp-2007-correspondence others.pdf | 2011-10-08 |
| 78 | 04549-kolnp-2007-description complete.pdf | 2011-10-08 |
| 78 | Assignment [27-04-2017(online)].pdf | 2017-04-27 |
| 79 | 04549-kolnp-2007-drawings.pdf | 2011-10-08 |
| 79 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [13-01-2018(online)].pdf | 2018-01-13 |
| 80 | 04549-kolnp-2007-form 1.pdf | 2011-10-08 |
| 80 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [30-03-2018(online)].pdf | 2018-03-30 |
| 81 | 04549-kolnp-2007-form 3.pdf | 2011-10-08 |
| 81 | 4549-KOLNP-2007-Response to office action (Mandatory) [25-01-2019(online)].pdf | 2019-01-25 |
| 82 | 04549-kolnp-2007-form 5.pdf | 2011-10-08 |
| 82 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [01-02-2019(online)].pdf | 2019-02-01 |
| 83 | 04549-kolnp-2007-gpa.pdf | 2011-10-08 |
| 83 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [25-03-2019(online)].pdf | 2019-03-25 |
| 84 | 04549-kolnp-2007-international publication.pdf | 2011-10-08 |
| 84 | 4549-KOLNP-2007-FORM-26 [23-09-2019(online)].pdf | 2019-09-23 |
| 85 | 04549-kolnp-2007-international search report.pdf | 2011-10-08 |
| 85 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [20-03-2020(online)].pdf | 2020-03-20 |
| 86 | 4549-KOLNP-2007-CORRESPONDENCE 1.2.pdf | 2011-10-08 |
| 86 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [29-09-2021(online)].pdf | 2021-09-29 |
| 87 | 4549-KOLNP-2007-CORRESPONDENCE 1.3.pdf | 2011-10-08 |
| 87 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [09-10-2021(online)].pdf | 2021-10-09 |
| 88 | 4549-KOLNP-2007-CORRESPONDENCE OTHERS 1.1.pdf | 2011-10-08 |
| 88 | 4549-KOLNP-2007-POWER OF AUTHORITY [12-04-2022(online)].pdf | 2022-04-12 |
| 89 | 4549-KOLNP-2007-FORM-16 [12-04-2022(online)].pdf | 2022-04-12 |
| 89 | 4549-kolnp-2007-form 18.pdf | 2011-10-08 |
| 90 | 4549-KOLNP-2007-ASSIGNMENT WITH VERIFIED COPY [12-04-2022(online)].pdf | 2022-04-12 |
| 90 | 4549-KOLNP-2007-FORM 3-1.1.pdf | 2011-10-08 |
| 91 | 4549-KOLNP-2007-FORM 3.1.pdf | 2011-10-08 |
| 91 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [23-08-2022(online)].pdf | 2022-08-23 |
| 92 | 4549-KOLNP-2007-PCT PRIORITY DOCUMENT NOTIFICATION.pdf | 2011-10-08 |
| 92 | 4549-KOLNP-2007-RELEVANT DOCUMENTS [14-09-2022(online)].pdf | 2022-09-14 |