DESC:FIELD OF THE INVENTION:
The present invention relates to synergistic pesticidal composition comprising A) Chlorantraniliprole B) at least one insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid C) at least one more insecticide selected from 5 Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate with one or more inactive excipients. The present invention also relates to process for preparing the said composition and its use in crops. 10 BACKGROUND OF THE INVENTION
Chlorantraniliprole was first disclosed WO 03/015518. Chlorantraniliprole is chemically known as 3-bromo-4'-chloro-1-(3-chloro-2-pyridyl)-2'-methyl-6'-15 (methylcarbamoyl)pyrazole-5-carboxanilide and having chemical structure as below;
Chlorantraniliprole has efficient mechanism which is activated by ryanodine receptor, excessive release of intracellular stores of calcium ions, resulting in the 20 death of the insect paralysis. Chlorantraniliprole is efficient broad-spectrum, for the purpose of Noctuidae phosphorus wing, bore fruit moth, leaf roller Branch, flour moth and other mouth Coleoptera Curculionidae, Chrysomelidae, Diptera Agromyzidae etc. are good control effect.
25 CN103109823A relates to novel composition butene-fipronil and chlorantraniliprole pesticide composition. The butene-fipronil and chlorantraniliprole pesticide composition comprises the components of butene-
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fipronil and chlorantraniliprole serving as active ingredients, as well as the balance of a pesticide adjuvant, wherein the weight ratio of the butene-fipronil and the chlorantraniliprole is (1:20)-(20:1), and the sum of the weight of the butene-fipronil and the chlorantraniliprole accounts for 0.1-80% of the weight of the composition.
5 CN102484994B relates to novel composition of matrine and Chlorantraniliprole, quality ratio matrine and Chlorantraniliprole of 50:1 to 1:50. The compositions include Matrine, oxymatrine and matrine mixture, or a series of alkaloids obtained from Sophora, bitter beans, broad beans and other plant roots extract and its preparations. 10
CN101720769A relates to novel composition and a preparation method and application thereof, wherein the insecticidal composition is a mixture comprising a compound (A), i.e. pymetrozine and a compound (B), i.e. chlorantraniliprole.
15 CN102318611A relates to a novel synergistic insecticidal composition which is a mixture of a compound (A) flubendiamide and a compound (B) chlorantraniliprole. The insecticidal composition can be processed in missible oils, suspending agents, wettable powders and water dispersible granules. The weight ratio of the compound (A) flubendiamide to the compound (B) chlorantraniliprole is (1-100) :( 1-100). 20
CN 200910069468 relates to novel composition comprising chlorantraniliprole with synergistic effective dose, abamectin or emamectin benzoate, and one of cyhalothrin, dursban, diazinon, acetamiprid, cypermethrin, alpha cypermethrin, thiamethoxam, thiacloprid, fenvalerate, propargite, diafenthiuron, benfuracarb, 25 azocyclotin, buprofezin, ethofenprox, phonamiphos, fipronil, flufenoxuron, monosultap, dimehypo, imidacloprid, flufenoxuron, chlorfluazuron, pleocidin and tebufenozide, wherein the mass percentage of the three compositions is that: the chlorantraniliprole is 1 to 35 percent, the abamectin or the emamectin benzoate is 1 to 10 percent, and any one of the insecticides is 1 to 50 percent. The invention 30 discloses a process for processing the compositions and application of the
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compositions in preparing insecticides for controlling agricultural, forestry and gardening insect pests.
However still there is a need for a pesticidal composition which overcomes some of the existing problems and can be prepared easily without much complex 5 manufacturing process.
Inventors of the present invention have surprisingly found that the pesticidal composition comprising synergistically effective amounts of A) Chlorantraniliprole B) at least one insecticide selected from Clothianidin, Thiamethoxam and 10 Imidacloprid C) at least one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate with one or more inactive excipients described herein in can provide solution to the above mentioned problems. Further the present invention increase efficacy against target insect-pests, broaden the activity means to control more than 15 one insect-pests at a time, reduce the total loading of insecticides in to the environment, provide safety to the applicators and crop ecosystem and last but not least delay or to manage resistance development. SUMMARY OF THE INVENTION 20 It is an aspect of the present invention is to provide, with a view to effective resistance management and effective control of harmful insects, at application rates which are as low as possible, compositions which, at a reduced total amount of active compounds applied, have improved activity against the harmful pests and a 25 broadened activity spectrum, in particular for certain indications.
We have accordingly found that this object is achieved by the present insecticidal compositions, defined herein, comprising A) Chlorantraniliprole B) at least one insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid C) at least 30 one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos,
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Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate with one or more inactive excipients.
Accordingly, in a main aspect of the present invention provides an insecticidal composition comprising A) Chlorantraniliprole B) at least one insecticide selected 5 from Clothianidin, Thiamethoxam and Imidacloprid C) at least one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate with one or more inactive excipients.
Accordingly, in a second aspect, the present invention provides a method of 10 preparing the insecticidal composition comprising A) Chlorantraniliprole B) at least one insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid C) at least one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate with one or more inactive excipients. 15
Accordingly, in a third aspect, the present invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against pathogenic damage or pest damage by applying to the plant propagation material an insecticidal composition defined in the 20 first aspect.
DETAILED DESCRIPTION OF THE INVENTION
The present invention provides solution to all the problems mentioned above by 25 providing the insecticidal composition.
The present invention provides an insecticidal composition comprising A) Chlorantraniliprole B) at least one insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid C) at least one more insecticide selected from 30 Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate with one or more inactive excipients.
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"Effective amounts” as mentioned herein means that amount which, when applied treatment of crops, is sufficient to effect such treatment.
The term “formulation” and “composition” as used herein conveys the same 5 meaning and can be used interchangeably.
The formulation or composition of the present invention can be in various physical forms, for example in the form of a GR (Granules, Soil Applied Granules), CR Granules (Controlled/Sustained Release Granules), MS (Microsphere/Microcapsule 10 Granules, SG (Soluble Granules), WG or WDG (Water Dispersible Granules), WP (Wettable Powder), SC (Suspension Concentrate), FS (Flowable Suspsension), CS (Capsule Suspension), SE (Suspo Emulsion), ZE (A mixed formulation of CS and SE), ZW (A mixed formulation of CS and EW) and OD (Oil Dispersion). 15 As per one embodiment, the synergistic pesticidal composition comprises A) Chlorantraniliprole B) at least one insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid C) at least one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate with one or more inactive excipients wherein active 20 ingredients are present in concentration as described below:
Compound A
Compound B
Compound C
Active ingredients
Chlorantraniliprole
Clothianidin Thiamethoxam Imidacloprid
Bifenthrin
Cartap Hydrochloride
Chlorpyrifos
Lambda Cyhalothrin
Thiocyclam
Hydrogen Oxalate
Concentration
0.1-20%
0.1-30%
0.1-50%
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According to a specific embodiment, the application rates of Chlorantraniliprole are from 10 g/ha to 80 g/ha. According to a specific embodiment, the application rates of Clothianidin are from 10 g/ha to 150 g/ha. According to a specific embodiment, the application rates of Thiamethoxam are from 10 g/ha to 150 g/ha. According to a specific embodiment, the application rates of Bifenthrin are from 10 g/ha to 100 5 g/ha. According to a specific embodiment, the application rates of Cartap Hydrochloride are from 100 g/ha to 750 g/ha. According to a specific embodiment, the application rates of Thiocyclam Hydrogen Oxalate are from 100 g/ha to 750 g/ha. 10 In another embodiment of the present invention the pesticidal composition comprising A) Chlorantraniliprole B) at least one insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid C) at least one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate with one or more inactive excipients effective 15 for control of Insect-pests in the crops selected from GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Jute (Corchorus oliotorus), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Ragi (Eleusine coracana), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) 20 , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Castor (Ricinus communis), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), 25 Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum 30 lycopersicun) , Potato (Solanum tuberosum) , Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus),
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Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa subsp rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango 5 (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain 10 (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation 15 (Dianthus caryophyllus).
In one embodiment of the present invention, the pesticidal composition of present invention controls pests and insects listed below;
20
Insects from the order of the Lepidoptera, for example Agrotis ypsilon, Alabama argillacea, Anticarsia gemmatalis, Cacoecia murinana, Capua reticulana, Chilo auricilius, Chilo infuscatellus, Chilo partellus, Chilo sacchariphagus, Chilo suppressalis, Choristoneura fumiferana, Choristoneura occidentalis, Cirphis unipuncta, Cnaphalocrocis medinalis, Cydia pomonella, Diatraea saccharalis, 25 Dendrolimus pini, Diaphania nitidalis, Earias vittella, Earias insulana, Elasmopalpus lignosellus, Emmalocera depressella, Eupoecilia ambiguella, Evetria bou-liana, Exelastis atomosa, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, Helicoverpa armigera, Helicoverpa virescens, Helicoverpa zea, Hellula undalis, Hibernia defoliaria, Hyphantria cunea, Hyponomeuta malinellus, Keiferia 30 lycopersicella, Laphygma exigua, Leucinodes orbonalis, Leucoptera coffeella, Leucoptera scitella, Lithocol-letis blancardella, Lobesia botrana, Loxostege
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sticticalis, Lymantria dispar, Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestra brassicae, Marasmia pantalis, Maruca vitrata, Maruca testulalis, Mythimna separata, Orgyia pseu-dotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris bras-sicae, Plathypena scabra, Plutella 5 xylostella, Pseudoplusia includens, Rhyacionia frus-trana, Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, Scrobipalpula absoluta, Sesamia inferens, Sitotroga cerealella, Sparganothis pilleriana, Spilosoma obliqua, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni, Tryporyza novella, Tuta absoluta and 10 Zeiraphera Canadensis. Beetles (Coleoptera), for example Adoretus bicolor, Agrilus sinuatus, Agriotes lineatus, Agriotes obscu-rus, Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum, Anomala benghalensis, Aphthona euphoridae, Apogonia aerea, Athous haemorrhoidalis, Atomaria linearis, Blasto-phagus piniperda, Blitophaga undata, Bruchus rufimanus, 15 Bruchus pisorum, Bruchus lentis, Byctiscus betulae, Cassida nebulosa, Cerotoma trifurcata, Cetonia aurata, Ceuthorrhynchus assimilis, Ceuthorrhynchus napi, Chaetocnema tibialis, Chiloloba acuta, Conoderus vespertinus, Crioceris asparagi, Ctenicera ssp., Diabrotica longicornis, Diabrotica semipunctata, Diabrotica punctata, Diabrotica speciosa, Diabrotica virgifera, Dicladispa armigera, Epila-20 chna varivestis, Epitrix hirtipennis, Eutinobothrus brasiliensis, Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Hylobius abietis, Hypera brunneipennis, Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, Leptinotarsa decemlineata, Lepidiota stigma, Limonius califomicus, Lissorhoptrus oryzophilus, Maladera indica, Melanotus communis, Meligethes aeneus, 25 Melolontha hippocastani, Melolontha melolontha, Oberea brevis, Oulema oryzae, Ortiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllobius pyri, Phyllotreta chrysocephala, Phyllophaga sp., Phyllopertha horticola, Phyllotreta nemorum, Phyllotreta striolata, Popillia japonica, Sitona lineatus and Sito-philus gran aria, flies, mosquitoes (Diptera), e.g. Atherigona orientalis, Calliphora vicina, 30 Ceratitis capitata, Chrysomya bezziana, Chrysomya hominivorax, Chrysomya macellaria, Chrysops discalis, Chrysops silacea, Chrysops atlanticus, Cochliomyia
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hominivorax, Contarinia sorghicola Cordylobia anthropophaga, Culicoides furens, Culiseta inornata, Culiseta melanura, Dacus cucurbi-tae, Dacus oleae, Dasineura brassicae, Delia antique, Delia coarctata, Delia platura, Delia radicum, Dermatobia hominis, Fannia canicularis, Geomyza Tripunctata, Gaster-ophilus intestinalis, Glossina morsitans, Glossina palpalis, Glossina fuscipes, Glossina tachinoides, 5 Haematobia irritans, Haplodiplosis equestris, Hippelates spp., Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Liriomyza sativae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola destructor, Melanagromyza obtuse, Muscina stabulans, Oestrus ovis, Ophiomyia phaseli, Opomyza florum, Orseolia oryzae, Oscinella frit, 10 Pegomya hysocyami, Phorbia antiqua, Phorbia brassicae, Phor-bia coarctata, Phlebotomus argentipes, Psorophora columbiae, Psila rosae, Psoro-phora discolor, Prosimulium mixtum, Rhagoletis cerasi, Rhagoletis pomonella, Sar-cophaga haemorrhoidalis, Sarcophaga sp., Simulium vittatum, Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, and Tabanus similis, Tipula ol-eracea, 15 and Tipula paludosa, thrips (Thysanoptera), e.g. Dichromothrips corbetti, Dichromothrips ssp , Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Scirtothrips dorsalis, Thrips oryzae, Thrips palmi and Thrips tabaci, termites (Isoptera), e.g. Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, 20 Odontotermes obesus, Reticulitermes flavipes, Termes natalensis. cockroaches (Blattaria - Blattodea), e.g. Blattella germanica, Penplaneta americana, Periplaneta japonica and Blatta orientalis, true bugs (Hemiptera), e.g. Acrosternum hilare, Acyrtho-siphon pisum, Acyrthosiphon onobrychis, Adelges laricis, Aleurolobus barodensis, Amrasca biguttula biguttula, Amrasca devastans, Amritodus atkinsoni, 25 Aphidula nasturtii, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gossypii, Aphis crassivora, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Aulacorthum solani, Bemisia argentifolii, Bemisia tabaci, Brachycaudus cardui, Brachy-caudus helichrysi, Brachycaudus persicae, Brachycaudus prunicola, Brevicoryne brassicae, Capitophorus horni, Cavalerius sweeti, Cerosipha gossypii, 30 Ceratovacuna lanigera, Chaetosiphon fragaefolii, Cicadulina spp., Clavigralla gibbosa, Cryptomyzus ribis, Dreyfusia nordmannianae, Dreyfusia piceae,
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Dysdercus cingulatus, Dysaphis radicola, Dysaulacorthum pseudosolani, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Hyperomyzus lactucae, Idioscopus spp. Leptoglossus phyllopus, Leptocorisa acuta, Lygus lineolaris, Lygus pratensis, Macrosiphum avenae, Macrosiphum euphorbiae, Ma-crosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, 5 My-zus persicae, Myzus ascalonicus, Myzus cerasi, Myzus varians, Nezara viridula, Nasonovia ribis-nigri, Nilaparvata lugens, Nephotettix virescens, Nephotettix nigropictus, Pemphigus bursarius, Perkinsiella saccharicida, Peregrinus maidis, Phorodon humuli, Planococcus spp., Pseudococcus spp., Pyrilla perpusilla, Psylla mail, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, 10 Rhopalosi-phum padi, Rhopalosiphum insertum, Saccharicoccus sacchari, Sappaphis mala, Sappaphis mail, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Sogatella furcifera, Trialeurodes vaporariorum, Toxoptera aurantiia, Psylla spp., Rhopalosiphum spp., Sitobion spp., ants, bees, wasps, sawflies (Hymenoptera), e.g. Athalia rosae, Atta cephalotes, Atta capiguara, Atta 15 cephalotes, Atta laevigata, Atta robusta, Atta sexdens, Atta texana, Crematogaster spp., Hoplocampa minuta, Hoplocampa testudinea, Monomorium pha-raonis, Solenopsis geminata, Solenopsis invicta, Solenopsis richteri, Solenopsis xyloni, Pogonomyrmex barbatus, Pogonomyrmex californicus, Pheidole megacephala, Dasy-mutilla occidentalis, Bombus spp. Vespula squamosa, Paravespula vulgaris, 20 Paraves-pula pennsylvanica, Paravespula germanica, Dolichovespula maculata, Vespa crabro, Polistes rubiginosa, Camponotus floridanus, and Linepithema humile, crickets, grasshoppers, locusts (Orthoptera), e.g. Acheta domestica, Gryllotalpa gryllo-talpa, Locusta migratoria, Melanoplus bivittatus, Melanoplus femurrubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melanoplus 25 spretus, Nomadacris septemfasciata, Schistocerca americana, Schistocerca gregaria, Dociostaurus maroccanus, Tachycines asynamorus, Oedaleus senegalensis, Zonozerus variegatus, Hieroglyphus daganensis, Kraussaria angulifera, Calliptamus italicus, Chortoicetes terminifera, and Locustana pardalina, Arachnoidea, such as arachnids (Acarina), e.g. of the families Argasidae, Ixodidae and Sarcoptidae, such 30 as Amblyomma americanum, Amblyomma variegatum, Ambryomma maculatum, Argas persicus, Boophilus annulatus, Boophilus decoloratus, Boophilus microplus,
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Dermacentor silvarum, Dermacentor andersoni, Dermacentor variabilis, Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Ixodes pacificus, Ornithodorus moubata, Ornithodorus hermsi, Ornithodo-rus turicata, Ornithonyssus bacoti, Otobius megnini, Dermanyssus gallinae, Psoroptes ovis, Rhipicephalus sanguineus, Rhipicephalus appendiculatus, Rhipicephalus 5 evertsi, Sarcoptes scabiei, and Eriophyidae spp. such as Aculus schlechtendali, Phyllocoptrata oleivora and Eriophyes sheldoni; Tarsonemidae spp. such as Phytonemus pallidus and Polyphagotarsonemus latus; Tenuipalpidae spp. such as Brevipalpus phoenicis; Tetra-nychidae spp. such as Tetranychus cinnabarinus, Tetranychus kanzawai, Tetranychus pacificus, Tetranychus telarius and 10 Tetranychus urticae, Panonychus ulmi, Panony-chus citri, and Oligonychus pratensis; Araneida, e.g. Latrodectus mactans, and Loxos-celes reclusa, fleas (Siphonaptera), e.g. Ctenocephalides felis, Ctenocephalides canis, Xenopsylla cheopis, Pulex irritans, Tunga penetrans, and Nosopsyllus fasciatus, silverfish, firebrat (Thysanura), e.g. Lepisma saccharina and Thermobia domestica,centipedes 15 (Chilopoda), e.g. Scutigera coleoptrata, millipedes (Diplopoda), e.g. Narceus spp., Earwigs (Dermaptera), e.g. forficula auricularia, lice (Phthiraptera), e.g. Pediculus humanus capitis, Pediculus humanus corporis, Pthi-rus pubis, Haematopinus eurystemus, Haematopinus suis, Linognathus vituli, Bovicola bovis, Menopon gallinae, Menacanthus stramineus and Solenopotes capillatus. Plant parasitic 20 nematodes such as root-knot nematodes, Meloidogyne arenaria, Meloi-dogyne chitwoodi, Meloidogyne exigua, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica and other Meloidogyne species; cyst nematodes, Globodera rostochiensis, Globodera pallida, Globodera tabacum and other Globodera species, Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, 25 and other Heterodera species; seed gall nematodes, Anguina funesta, Anguina tritici and other Anguina species; stem and foliar nematodes, Aphelenchoides besseyi, Aphelen-choides fragariae, Aphelenchoides ritzemabosi and other Aphelenchoides species; sting nematodes, Belonolaimus longicaudatus and other Belonolaimus species; pine nematodes, Bursaphelenchus xylophilus and other Bursaphelenchus 30 species; ring ne-matodes, Criconema species, Criconemella species, Criconemoides species, and Me-socriconema species; stem and bulb nematodes, Ditylenchus
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destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and other Ditylenchus species; awl nematodes, Dolichodorus species; spiral nematodes, Helicotylenchus dihystera, Helicotylenchus multicinctus and other Helicotylenchus species, Rotylenchus robustus and other Roty-lenchus species; sheath nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; 5 lance nematodes, Hoplolaimus columbus, Hoplolai-mus galeatus and other Hoplolaimus species; false root-knot nematodes, Nacobbus aberrans and other Nacobbus species; needle nematodes, Longidorus elongates and other Longidorus species; pin nematodes, Paratylenchus species; lesion nematodes, Pratylenchus brachyurus, Pratylenchus coffeae, Pratylenchus curvitatus, Pratylenchus goodeyi, 10 Pratylencus neglectus, Pratylenchus penetrans, Pratylenchus scribneri, Pratylenchus vulnus, Pratylenchus zeae and other Pratylenchus species; Radinaphelenchus cocophilus and other Radinaphelenchus species; burrowing nematodes, Radopholus similis and other Radopholus species; reniform nematodes, Rotylenchulus reniformis and other Rotylenchulus species; Scutellonema species; stubby root 15 nematodes, Tri-chodorus primitivus and other Trichodorus species; Paratrichodorus minor and other Paratrichodorus species; stunt nematodes, Tylenchorhynchus claytoni, Tylenchorhyn-chus dubius and other Tylenchorhynchus species and Merlinius species; citrus nematodes, Tylenchulus semipenetrans and other Tylenchulus species; dagger nematodes, Xiphinema americanum, Xiphinema index, 20 Xiphinema diversicaudatum and other Xi-phinema species; and other plant parasitic nematode species.
The pesticidal composition according to the invention can be applied to any and all developmental stages of pests, such as egg, larva, pupa, and adult. The pests may be 25 controlled by contacting the target pest, its food supply, habitat, breeding ground or its locus with an effective amount of the composition of present invention.
The inventive mixtures or of composition comprising the mixtures are highly effective in controlling insect pests, in Sugarcane crop- Termites Odontotermes 30 spp., Coptotermes spp., Heterotermes spp., Leucotermes spp., Microtermes obesi, Whitegrub, Holotrichia consanguinea, Holotrichia serrata, Maladera insanabilis,
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Brahmina spp., Melolontha spp., Lepidiota spp., Anomala spp., Phyllognathus spp., Leucopholis spp., Wireworms, Limonius spp., Agriotes spp., Early shoot borer Chilo infuscatellus, Pink borer Sesamia inferens, Top shoot borer Scirpophaga excerptalis, Root borer Emmalocera depressella, Internode borer: Chilo sacchariphagus indicus, Stalk borer Chilo auricilius, White woolly aphid 5 Ceratovacuna lanigera, Black bug Cavelerius sweeti, Whitefly Aleurolobus barodensis, Pyrilla Pyrilla perpusilla, Mealybug Saccharicoccus sacchari. In rice/paddy crop- Termites, root weevil Lissorhoptus oryzophilus, Echinocnemus oryzae, Hydronomodius molitor, stem borer, Chilo suppressalis, Schirpophaga incertulas, Sesamia inferens, Hoppers, Nilaparvata lugens, Sogatella furcifella, 10 Nephotettix nigropictus, Gall midge, Orseolia oryzae, Leaffolder Cnaphalocrocis medinalis, Rice bug, Leptocorisa spp., Stink bug, Nezara spp., Rice Hispa, Dicladispa armigera, Caseworm Nymphula depuctalis, whorl maggot, Hydrellia spp., black bug, Scotinophara coarctata, armyworm, Mythimna separate, Mole cricket Gryllotalpa spp., Stem maggot, Chlorops oryzae and soil earthworm 15 (oligochaeta).
Method of Applications :
The composition of present invention can be applied by any of the below mentioned method; 20
Broadcasting of Granules, Controlled Release Granules (CR), Slow release and Fast release Microsphere/Microcapsule Granules (MS) by manual (by hand), by hand or power operated granules spreader, by machine operated soil granules applicators. It can be a sand mix or fertilizer mix broadcasting. Broadcasting can be done before or after crop sowing, planting or transplanting or at the time of land preparation. In 25 sugarcane, broadcasting can be done manually by mixing it with sand or fertilizer and by spreading over cane sett, in open furrow before covering it with soil at the time of planting. In rice, broadcasting can be done manually by mixing it with sand or fertilizer after transplanting the crop.
Seed treatment to seeds, plant propagating materials 30
Page 15 of 44
Foliar application / spraying
Soil drenching
Through drip irrigation
Nursery bed application
Mixing in to soil or other plant growing media in protected cultivations, green 5 houses, net houses, poly houses. The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased. Noteworthy, the health of a plant when applying the method according to the invention, is increased 10 independently of the pesticidal properties of the active ingredients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which result for example in an activation of the plant's own natural defense system. As a result, the health of a plant is increased even in the absence of pest pressure. Accordingly, in an especially 15 preferred embodiment of the method according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. The above identified indicators for the health condition of a plant may be interdependent or they may result from each other. An increase in plant vigor may for example result in an increased yield and/or tolerance to abiotic or biotic stress. 20 One indicator for the condition of the plant is the yield. "Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and/or 25 processed after harvesting. In an especially preferred embodiment of the invention, the yield of the treated plant is increased. 30
Page 16 of 44
In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically. According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product 5 of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention. Increased yield can be characterized, among others, by the following improved 10 proper-ties of the plant: increased plant weight, increased plant height, increased biomass such as higher overall fresh weight (FW), increased number of flowers per plant, higher grain yield, more tillers or side shoots (branches), larger leaves, increased shoot growth, increased protein content, increased oil content, increased starch content, increased pigment content, increased leaf are index. 15 A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance. In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the 20 plant vigor of the plants treated according to the method of the invention, is increased synergistically. Improved plant vigor can be characterized, among others, by the following improved properties of the plant: improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less plant verse/lodging), improved emergence, enhanced 25 root growth and/or more developed root system, enhanced nodulation, in particular rhizobial nodulation, bigger leaf blade, bigger size, increased plant weight, increased plant height, increased tiller number, increased number of side shoots, increased number of flowers per plant, increased shoot growth, increased root growth (extensive root system), increased yield when grown on poor soils or 30
Page 17 of 44
unfavorable climate, enhanced photosynthetic activity (e.g. based on increased stomatal conductance and/or increased C02 assimilation rate), increased stomatal conductance, increased C02 assimilation rate, enhanced pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, earlier and improved germination, earlier grain maturity, improved self-defense mechanisms, improved 5 stress tolerance and resistance of the plants against biotic and abiotic stress factors such as fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and/or salt stress, less non-productive tillers, less dead basal leaves, less input needed (such as fertilizers or water), greener leaves, complete maturation under shortened vegetation periods, less fertilizers needed, less seeds needed, easier 10 harvesting, faster and more uniform ripening, longer shelf-life, longer panicles, delay of senescence, stronger and/or more productive tillers, better extractability of ingredients, improved quality of seeds (for being seeded in the following seasons for seed production), better nitrogen uptake, improved reproduction, reduced production of ethylene and/or the inhibition of its reception by the plant. 15 The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components). 20 Another indicator for the condition of the plant is the "quality" of a plant and/or its products. In an especially preferred embodiment of the invention, the quality of the treated 25 plant is increased. In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically. 30
Page 18 of 44
According to the present invention, enhanced quality means that certain plant characteristics such as the content or composition of certain ingredients are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the application of the mixtures of the present invention. Enhanced quality can be characterized, among 5 others, by following improved properties of the plant or its product: increased nutrient content, increased protein content, increased content of fatty acids, increased metabolite content, increased carotenoid content, increased sugar content, increased amount of essential amino acids, improved nutrient composition, improved protein composition, improved composition of fatty acids, improved 10 metabolite composition, improved carotenoid composition, improved sugar composition, improved amino acids composition, improved or optimal fruit color, improved leaf color, higher storage capacity, higher process ability of the harvested products. 15 Another indicator for the condition of the plant is the plant's tolerance or resistance to biotic and/or abiotic stress factors. Biotic and abiotic stress, especially over longer terms, can have harmful effects on plants. Biotic stress is caused by living organisms while abiotic stress is caused for example by environmental extremes. According to the present invention, "enhanced tolerance or resistance to biotic 20 and/or abiotic stress factors" means (1) that certain negative factors caused by biotic and/or abiotic stress are diminished in a measurable or noticeable amount as compared to plants exposed to the same conditions, but without being treated with a mixture according to the invention and (2) that the negative effects are not diminished by a direct action of the mixture according to the invention on the stress 25 factors, e.g. by its fungicidal or insecticidal action which directly destroys the microorganisms or pests, but rather by a stimulation of the plants' own defensive reactions against said stress factors.
One or more inactive excipient is selected from including but not limited to 30 dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-
Page 19 of 44
microbial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”), fillers, fillers and buffering agent. Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or stearic barrier to re-aggregation of 5 particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersants are sodium lignosulphonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulphonate formaldehyde condensates. Tristyrylphenolethoxylate phosphate esters 10 are also used. Nonionics such as alkylarylethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersants for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the 15 ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersants used herein include but not limited to sodium lignosulphonates; sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenolethoxylate 20 phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EO-PO block copolymers; and graft copolymers or mixtures thereof.
Anti-freezing agent as used herein can be selected from the group consisting of polyethylene glycols, methoxypolyethylene glycols, polypropylene glycols, 25 polybutylene glycols, glycerin and ethylene glycol.
Water-based formulations often cause foam during mixing operations in production. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two 30 types of anti-foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane while the non-silicone anti-foam
Page 20 of 44
agents are water-insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.
A wetting agent is a substance that when added to a liquid increases the spreading 5 or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a 10 spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules. Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations include but not limited to sodium lauryl sulphate; sodium dioctylsulphosuccinate; alkyl phenol ethoxylates; and aliphatic alcohol 15 ethoxylates and the salts thereof which are standard in agricultureor mixtures thereof. Suspension aid in the present description denotes a natural or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate 20 its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chlorinated 25 hydrocarbons, liquefied gases, and the like or mixtures thereof). Biocides / Microorganisms cause spoilage of formulated products. Therefore anti-microbial agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt; sorbic acid 30 and its sodium or potassium salts; benzoic acid and its sodium salt; p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium
Page 21 of 44
benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates or mixtures thereof. Thickeners or gelling agents are used mainly in the formulation of suspension 5 concentrates, emulsions and suspo-emulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. 10 Examples of these types of materials, include, but are limited to, montmorillonite, bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of 15 these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixtures. 20
The quick coating agent can be a conventionally available sticker, for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate 25 and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymersand mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic 30 polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate
Page 22 of 44
polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of 5 biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood 10 rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof.
Buffering agent as used herein is selected from group consisting of calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated 15 apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.
The solvent for the formulation of the present invention may include water, water-20 soluble alcohols and dihydroxy alcohol ethers. The water-soluble alcohol which can be used in the present invention may be lower alcohols or water-soluble macromolecular alcohols. The term "lower alcohol", as used herein, represents an alcohol having 1-4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, etc. Macromolecular alcohol is not limited, as 25 long as it may be dissolved in water in a suitable amount range, polyethylene glycol, sorbitol, glucitol, etc. The examples of suitable dihydroxy alcohol ethers used in the present invention may be dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, 30 dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. The
Page 23 of 44
examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, and the like. Any of the above mentioned solvent can be used either alone or in combination thereof.
5 Following materials can be also used as fillers, fillers cum absorbent or bulk carrier in solid formulations (WG, Granules, Slow/fast release granules etc.) and as buffering, dispersing, wetting or anti-freezing agents in liquid formulations (SC, ZC) are; Zinc Sulphate Monohydrate (ZnSO4,H2O), Zinc Sulphate Heptahydrate (ZnSO4,7H2O ), Zinc Oxysulphate (ZnSO4xZnO), Zinc Oxide (ZnO), Zinc 10 carbonate (ZnCO3), Zinc Chloride (ZnCl2), Zinc EDTA/Zinc chelate, Zinc Gluconate, Zinc Lactate Gluconate, Zinc Polyflavonoid, Zinc lignosulphate, Sulphur, Single superphosphate, Triple super phosphate, rock phosphate, potassium chloride, potassium sulphate, potassium schoenite, Sulphur, Di-ammonium phosphate, Manganese sulphate, sodium tetraborate, copper sulphate, ferrous 15 sulphate, ammonium molybdate, chelated iron as Fe-EDTA, magnesium sulphate, boric acid, di-sodium octa borate tetra hydrate, di-sodium tetra borate penta hydrate, anhydrous borax, zincated bentonite sulphur, boronated sulphur. The materials from plant, animal or soil origin are humic acid (sodium salt or potassium salt, Ammonium humate, Potassium humate), fulvic acid (Potassium fulvate, Zinc 20 Fulvate), protein hydrolysate (N containing organic compounds), organic nitrogen, amino acids and peptides, seaweed extract (Ascophyllum nodosum), microbial extract, plant extract, vitamin B, chitin, chitosan and microbial inoculants. The major microbial are nitrogen fixing or solubilizing (Rhizobium spp., Azotobacter spp., Azospirillum spp., Acetobacter spp.), Phosphate solubilizing microbes 25 (Bacillus megaterium var. phosphaticum, Bacillus polymyxa), potash solubilizing microbes (Bacillus licheniformis, Frateuria aurantia), sulphur solubilizing microbes (Thiobacillus thiooxidans), VAM (Vesicular Arbuscular Mycorrhiza) (Glomus fasciculatum), fungus, Potassium mobilizing microbes, zinc solubilizing microbes (Acinetobacter calcoaceticus), Bacillus subtilis, Bacillus thuringiensis var. kurstaki, 30 Pseudomonas fluorescens, Beauveria bassina, Metarrhizium anisopliae, Varticillium
Page 24 of 44
lecanii, Trichoderma viride, Trichoderma harzianum, Paecilomyces lilacinus, Trichoderma spp. Etc.
Humic acid (sodium salt or potassium salt, Ammonium humate, Potassium humate), fulvic acid (Potassium fulvate, Zinc Fulvate), protein hydrolysate (N 5 containing organic compounds), organic nitrogen, amino acids and peptides, seaweed extract (Ascophyllum nodosum), microbial extract, plant extract, vitamin B, chitin, chitosan and microbial inoculants, VAM (Vesicular Arbuscular Mycorrhiza) (Glomus fasciculatum) may be used as fillers, fillers cum absorbent or bulk carrier in solid formulations (WDG/WG, Granules, Slow/fast release granules) 10 and as buffering, dispersing, wetting or anti-freezing agents in liquid formulations (SC, SE, ZC, ZE).
Example 1: Granules formulation of chlorantraniliprole 0.5% + clothianidin 1% + bifenthrin 0.5% : 15
Chemical composition
% (w/w)
chlorantraniliprole a.i.
0.50
clothianidin a.i.
1.00
bifenthrin a.i.
0.50 polyaryl phenol ethoxylate & calcium dodecyl benzene solphonate Blend
1.00
phosphoric acid
0.05
azo dye
0.05
diacetone alcohol
2.00
china clay
3.00
river sand
Q.S.
TOTAL
100.00
Manufacturing process of Granules (GR)
Step 1
Charged required quantity of carrier into the booth mixture with help of bucket elevator, then add other raw material (as technical, solvent, Surfactant, stabilizer, and binder) into the booth mixture and at this point add filler and allow mixing for another 20 minutes for homogenization.
Step 2
After completion of raw material addition and proper mixing, stop booth mixture for sampling.
Page 25 of 44
Step 3
Sample is sent for QC approval and approved material is unloaded in 25 Kg HDPE wooven bags.
Example 2: Granules formulation of chlorantraniliprole 0.5% + clothianidin 1% + cartap hydrochloride 3.75% :
5
Chemical composition
% (w/w)
chlorantraniliprole a.i.
0.50
clothianidin a.i.
1.00
cartap hydrochloride a.i.
3.75 polyaryl phenol ethoxylate & calcium dodecyl benzene solphonate Blend
1.00
phosphoric acid
0.05
azo dye
0.05
diacetone alcohol
2.00
china clay
2.00
river sand
Q.S.
TOTAL
100.00
Procedure: as per Example 1
Example 3: Granules formulation of chlorantraniliprole 0.5% + clothianidin 1% + thiocyclam hydrogen oxalate 3%: 10
chemical composition
% (w/w)
chlorantraniliprole a.i.
0.50
clothianidin a.i.
1.00
thiocyclam hydrogen oxalate a.i.
3.00 polyaryl phenol ethoxylate & calcium dodecyl benzene solphonate Blend
1.00
phosphoric acid
0.05
azo dye
0.05
diacetone alcohol
2.00
china clay
2.00
river sand
Q.S.
TOTAL
100.00
Procedure: as per Example 1
Page 26 of 44
Example 4: Granules formulation of chlorantraniliprole 0.5% + thiamethoxam 1% + bifenthrin 0.5% Granules
5
chemical composition
% (w/w)
chlorantraniliprole a.i.
0.50
thiamethoxam a.i.
1.00
bifenthrin a.i.
0.50 polyaryl phenol ethoxylate & calcium dodecyl benzene solphonate Blend
1.00
phosphoric acid
0.05
azo dye
0.05
diacetone alcohol
2.00
china clay
3.00
river sand
Q.S.
TOTAL
100.00
Procedure: as per Example 1
10
Example 5: Granules formulation of chlorantraniliprole 0.5% + thiamethoxam 1% + cartap hydrochloride 3.75%
chemical composition
% (w/w)
chlorantraniliprole a.i.
0.50
thiamethoxam a.i.
1.00
cartap hydrochloride a.i.
3.75 polyaryl phenol ethoxylate & calcium dodecyl benzene solphonate Blend
1.00
phosphoric acid
0.05
azo dye
0.05
diacetone alcohol
2.00
china clay
2.00
river sand
Q.S.
TOTAL
100.00
15
Procedure: as per Example 1
Page 27 of 44
Example 6: Granules formulation of chlorantraniliprole 0.5% + thiamethoxam 1% + thiocyclam hydrogen oxalate 3%
5
chemical composition
% (w/w)
chlorantraniliprole a.i.
0.50
thiamethoxam a.i.
1.00
thiocyclam hydrogen oxalate a.i.
3.00 polyaryl phenol ethoxylate & calcium dodecyl benzene solphonate Blend
1.00
phosphoric acid
0.05
azo dye
0.05
diacetone alcohol
2.00
china clay
2.00
river sand
Q.S.
TOTAL
100.00
Procedure: as per Example 1
10
Example 7: Zeon Concentrate (ZC) formulation of chlorantraniliprole 5% + clothianidin 12.5% + bifenthrin 10%
Chemical Composition
Percent (% w/w)
Chlorantraniliprole a.i.
5.00
Clothianidin a.i.
12.50
Bifenthrin a.i.
10.00
Acralic graft polymer
1.50
Fatty alcohol Ethoxylated
0.75
MonoEthyleneGlycol
2.50
Sodium salt of naphthalene sulfonate condensate
0.50
1, 2- benzisothiazolin-3-one
0.10
Toluene Diisocynate 0.32
Polymethyl polyphenyl Isocynate
0.02
Mixture of heavy Aromatic Hydrocarbons
8.00
Silicon Dioxide
0.30
Polyaryl phenol ethoxylate
0.50
Modified styrene acrylic polymer
1.00
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Xanthan powder
0.10
Silicone Antifoam
0.50
Water
QS
Total
100.00
Manufacturing proccess of Zeon Concentrate (ZC)
Part 1 Capsule suspension
Step 1
Oil Phase: Take required quantity C-9 Solvent in vessel then add required quantity of Technical and Add Polymethaline polyphenyl isocynate and Toluen Diisocynate and homogenise for approx. for 1 hours.
Step 2
Aqueous Phase: Take required quantity of water Add required quantity of Wetting agent, dispersing agent & Monoethylene Glycol and homogenize the contents for 1 hours.
Step 3
Now mix the oil phase slowly in aqueous phase then stir for another 1 hours till required particle size is achieved.
Step 4
Finally add required quantity of 2% of xanthum gum solution to this formulation
Step 5
Final product is sent for QC approval.
Part 2 Suspension Concentrate
Step 1
Charge required quantity of DM water need to be taken in designated vessel for Suspension concentrate production.
Step 2
Add required quantity of Wetting agent, antifreeze, dispersing agent & suspending agents and homogenize the contents for 45 – 60 minutes using high shear homogenizer.
Step 3
Then add technical and other remaining adjuvants excluding ‘thickener’ are added to it and homogenized to get uniform slurry ready for grinding.
Step 4
Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 5
After grinding material is transferred in CS Vessel.
Step 6
Final product is sent for QC approval.
Part 3 Mixing CS + SC
Step 1
After getting approval from QC department SC part is added in CS Vessel and homogenized for 30 minutes.
Step 2
Finally remaining 2% Xanthum Gum is added to it and homogenized for 20 minutes.
Step 3
Now Final Formulation is sent for quality check.
Step 4
After approval material is packed in required pack sizes.
5
Procedure: as per Example 7
Page 29 of 44
Example 8: Zeon Concentrate (ZC) formulation of chlorantraniliprole 5% + clothianidin 12.5% + lambda cyhalothrin 2.5%
5
Chemical Composition
Percent (% w/w)
Chlorantraniliprole a.i.
5.00
Clothianidin a.i.
12.50
Lambda Cyhalothrin a.i.
2.50
Acralic graft polymer
1.50
Fatty alcohol Ethoxylated
1.00
MonoEthyleneGlycol
2.50
Sodium salt of naphthalene sulfonate condensate
0.50
1, 2- benzisothiazolin-3-one
0.20
Toluene Diisocynate 0.01
Polymethyl polyphenyl Isocynate
0.02
Aromatic C-9 solvent
1.50
Silicon Dioxide
0.30
Polyaryl phenol ethoxylate
0.15
Calcium dodecyl benzene sulfonate
0.15
Modified styrene acrylic polymer
0.20
Xanthan powder
0.15
Silicone Antifoam
0.50
Water
QS
Total
100.00
Procedure: as per Example 7
10
Example 9: Zeon Concentrate (ZC) formulation of chlorantraniliprole 5% + thiamethoxam 12.5% + bifenthrin 10%
15
Chemical Composition
Percent (% w/w)
Chlorantraniliprole a.i.
5.00
Thiamethoxam a.i.
12.50
Bifenthrin a.i.
10.00
Page 30 of 44
Acralic graft polymer
1.50
Fatty alcohol Ethoxylated
0.75
MonoEthyleneGlycol
2.50
Sodium salt of naphthalene sulfonate condensate
0.50
1, 2- benzisothiazolin-3-one
0.10
Toluene Diisocynate 0.32
Polymethyl polyphenyl Isocynate
0.02
Mixture of heavy Aromatic Hydrocarbons
8.00
Silicon Dioxide
0.30
Polyaryl phenol ethoxylate
0.50
Modified styrene acrylic polymer
1.00
Xanthan powder
0.10
Silicone Antifoam
0.50
Water
QS
Total
100.00
Procedure: as per Example 7
5
Example 10: Zeon Concentrate (ZC) formulation of chlorantraniliprole 5% + thiamethoxam 12.5% + lambda cyhalothrin 2.5%
Chemical Composition
Percent (% w/w)
Chlorantraniliprole a.i.
5.00
Thiamethoxam a.i.
12.50
Lambda Cyhalothrin a.i.
2.50
Acralic graft polymer
1.50
Fatty alcohol Ethoxylated
1.00
MonoEthyleneGlycol
2.50
Sodium salt of naphthalene sulfonate condensate
0.50
1, 2- benzisothiazolin-3-one
0.20
Toluene Diisocynate 0.01
Polymethyl polyphenyl Isocynate
0.02
Aromatic C-9 solvent
1.50
Silicon Dioxide
0.30
Polyaryl phenol ethoxylate
0.15
Calcium dodecyl benzene sulfonate
0.15
Page 31 of 44
Modified styrene acrylic polymer
0.20
Xanthan powder
0.15
Silicone Antifoam
0.50
Water
QS
Total
100.00
Example 11 to 28 Most Preferred formulations
Ex no
a.i.1
a.i.2
a.i.3
Formulation Strength (%)
Formulation Type
Application Rate (g per hectare)
g.a.i per hectare
a.i.1
a.i.2
a.i.3
11
0.5%
a.i.2(1): 1%
Bifenthrin : 0.5%
2
Granule
10000
50.00
100.00
50.00
12
0.5%
a.i.2(1): 1%
Cartap Hydrochloride : 3.75%
5.25
Granule
10000
50.00
100.00
375.00
13
0.4%
a.i.2(1): 0.8%
Chlorpyrifos : 6%
7.2
Granule
12500
50.00
100.00
750.00
14
0.5%
a.i.2(1):1%
Thiocyclam Hydrogen Oxalate: 3%
4.5
Granule
10000
50.00
100.00
300.00
15
0.5%
a.i.2(2) :1%
Bifenthrin : 0.5%
2
Granule
10000
50.00
100.00
50.00
16
0.5%
a.i.2(2) :1%
Cartap Hydrochloride: 3.75%
5.25
Granule
10000
50.00
100.00
375.00
17
0.4%
a.i.2(2) :0.8%
Chlorpyrifos : 6%
7.2
Granule
12500
50.00
100.00
750.00
18
0.5%
a.i.2(2) :1%
Thiocyclam Hydrogen Oxalate : 3%
4.5
Granule
10000
50.00
100.00
300.00
19
0.5%
a.i.2(3) :1%
Bifenthrin : 0.5%
2
Granule
10000
50.00
100.00
50.00
20
0.5%
a.i.2(3) :1%
Cartap Hydrochloride: 3.75%
5.25
Granule
10000
50.00
100.00
375.00
21
0.4%
a.i.2(3) :0.8%
Chlorpyrifos : 6%
7.2
Granule
12500
50.00
100.00
750.00
22
0.5%
a.i.2(3) :1%
Thiocyclam Hydrogen Oxalate : 3%
4.5
Granule
10000
50.00
100.00
300.00
23
5%
a.i.2(1) :12.5%
Bifenthrin : 10%
27.5
ZC
400
20.00
50.00
40.00
24
5%
a.i.2(1) :12.5%
Lambda Cyhalothrin: 2.5%
20
ZC
400
20.00
50.00
10.00
25
5%
a.i.2(2)
Bifenthrin :
27.5
ZC
400
20.
50.0
40.0
Page 32 of 44
:12.5%
10%
00
0
0
26
5%
a.i.2(2) :12.5%
Lambda Cyhalothrin : 2.5%
20
ZC
400
20.00
50.00
10.00
27
5%
a.i.2(3)
Bifenthrin: 10 %
27.5
ZC
400
20.00
50.00
40.00
28
5%
a.i.2(3) :12.5%
Lambda Cyhalothrin : 2.5%
20
ZC
400
20.00
50.00
10.00
[a.i.1: Chlorantraniliprole ; a.i.2(1): Clothianidin; a.i.2(2): Thiamethoxam; a.i.2(3): Imidacloprid;]
Biological Examples:
Field experiments of inventive synergistic mixtures of 5
chlorantraniliprole+clothianidin+bifenthrin,
chlorantraniliprole+clothianidin+thiocyclam hydrogen oxalate, chlorantraniliprole+thiamethoxam+bifenthrin,
chlorantraniliprole+thiamethoxam+thiocyclam hydrogen oxalate
on sugarcane crop evaluate bio-efficacy against different insect-pests damaging the 10 crops.
A synergistic effect exists wherever the action of a combination of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticidal activity than the sum of 15 the pesticidal activities of the individual components.
In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “Calculation of the synergistic and antagonistic responses of insecticide combinations” published in the journal Weeds, 20 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two active components can be calculated as follows:
Page 33 of 44
The synergistic insecticidal action of the inventive mixtures can be demonstrated by the experiments below. 5
FIELD BIO-EFFICACY STUDIES:
EXPERIMENT 1:
10
Control of Sugarcane insect-pests.
Crop & Variety : Sugarcane, Co-0118
Location : Dhanaula, Dist. Amroha, Uttar Pradesh
Treatments : 8 (Set 1), 24 (Set 2)
Plot size : 50 sq. mt. (10 m x 5 m) 15
Spacing : 90 cm row to row
Planting material : 3 budded setts, 4 setts per meter
Date of sowing : 16 March 2017
Date of Application : At the time of planting, 16 March 2017
Method of Application: In furrow application, over the setts and then cover up with 20 soil
Date of Harvesting : 16 March 2018
Fertilizer : 100 kg per ha. DAP (diammonium phosphate) as basal dose at plating.
Agronomic Practices : Fertilizer, irrigation, inter culturing, earthing up and 25 weeding done as per the crop requirement.
Observation Methods: 30
Germination (%):
The germination (%) was recorded after 45 days of planting using following formula.
E = X + Y + Z - { XY + YZ + XZ } + ( X Y Z )
100 10000
Where E = Expected % control by mixture of three products A, B and C in a defined dose
X = Observed % control by product A
Y = Observed % control by product B
Z = Observed % control by product C
Ratio = Observed Control %
Expected Control %
Ratio of O/E > 1, means synergism observed.
Page 34 of 44
Number of emerging shoots
Percent germination of Buds = ----------------------------------------- X 100
Total number of buds planted
5
Shoot count:
The number of shoots were counted from 1 mrl (meter row length) from randomly selected 5 spot per plot.
The percent increase in shoot over untreated control were calculated by below formula. 10
Number of shoots in treatment
Percent increase over untreated control = 100 X ------------------------------------------------ - 100
Number of shoots in untreated control
15
Early shoot borer (Chilo infuscatellus) incidence (%):
Fifty shoots per plot were selected randomly and presence of characteristic “dead heart” (damaged shoots) were recorded to calculate per cent shoot damage by early shoot borer. 20
Damaged shoots
Percent shoot damage = -------------------------------------------------- X 100
Total number of shoots observed (50)
Plant damage by Termite (Odontotermes spp. And Microtermes spp.) (%): 25
Ten plants at random from each plot were observed to record the plant damage due to termites at 60 and 120 days after sowing (planting)
Damaged plants 30
Percent plant damage = ------------------------------------------- X 100
Total number of plants observed
Plant damage by White grub (Holotrichia consanguinea) (%): 35
Ten plants at random from each plot were observed to record the plant damage due to white grub at 120 days after sowing (planting).
Damaged plants due to White grub 40
Percent plant damage = ------------------------------------------------- X 100
Total number of plants observed
White grub larval count:
Page 35 of 44
The soil from three spot (30 cm x 30 cm x 30 cm) at random from each plot were dugged out from root zone taken out and presence of grub / larvae were recorded at 120 days after sowing (planting).
Table 1:Synergism in efficacy against early shoot borer (Chilo infuscatellus) control 5 in sugarcane (Set 1)
Treatment Details
Formulation (kg or ml per h)
Active Ingredient (g/h)
% Early shoot borer control Observed
% Early shoot borer control Expected
Colby Ratio o/e
45 DAS
60 DAS
45 DAS
60 DAS
45 DAS
60 DAS
Chlorantraniliprole 0.5%+ Clothianidin 1%+Bifenthrin 0.5% Granule
10 kg
50+100+50
100.0
98.8
91.71
89.35
1.09
1.11
Chlorantraniliprole 0.5% Granule + Clothianidin 1% Granule (tank mix)
10 kg+10 kg
50+100
82.6
78.8
84.98
81.45
0.97
0.97
Chlorantraniliprole 0.5% Granule +Bifenthrin 10% EC (tank mix)
10 kg+500 ml
50+50
81.2
80.4
83.55
81.52
0.97
0.99
Clothianidin 1% Granule +Bifenthrin 10% EC (tank mix)
10 kg+500 ml
100+50
70.6
64.6
72.18
66.94
0.98
0.97
Chlorantraniliprole 0.5% Granule
10 kg
50
70.2
67.8
Clothianidin 1% Granule
10 kg
100
49.6
42.4
Bifenthrin 10% EC
500 ml
50
44.8
42.6
Unweeded control
0
0
0.0
0.0
kg- killogram, h-hectare, UTC- Untreated Check, DAS- Days After sowing
The field trials data (table 1) shows that synergistic activities of chlorantraniliprole+clothianidin+bifenthrin has been observed in terms of efficacy 10 against early shoot borer infesting sugarcane crop.
Table 2: Treatment details
Treatment Number
Composition
Application Rate/Hectare
Formulation (kg)
gram active
1
Chlorantraniliprole 0.5%+Clothianidin 1%+Bifenthrin 0.5% Granule
10 kg
50+100+50
2
Chlorantraniliprole 0.5%+Clothianidin 1%+Thiocyclam 3% Granule
10 kg
50+100+300
3
Chlorantraniliprole 0.5%+Thiamethoxam 1%
10 kg
50+100+50
Page 36 of 44
+Bifenthrin 0.5% Granule
4
Chlorantraniliprole 0.5%+Thiamethoxam 1%+Thiocyclam 3% Granule
10 kg
50+100+300
5
Chlorantraniliprole 0.5%+Imidacloprid 1% +Bifenthrin 0.5% Granule
10 kg
50+100+50
6
Chlorantraniliprole 0.5%+Imidacloprid 1%+Thiocyclam 3% Granule
10 kg
50+100+300
7
Chlorantraniliprole 0.5%+Clothianidin 1% Granule
10 kg
50+100
8
Chlorantraniliprole 0.5%+Thiamethoxam 1% Granule
10 kg
50+100
9
Chlorantraniliprole 0.5%+Imidacloprid 1% Granule
10 kg
50+100
10
Chlorantraniliprole 0.5%+Bifenthrin 0.5% Granule
10 kg
50+50
11
Chlorantraniliprole 0.5%+Thiocyclam Hydrogen Oxalate 3% Granule
10 kg
50+300
12
Clothianidin 1%+Bifenthrin 0.5% Granule
10 kg
100+50
13
Clothianidin 1%+Thiocyclam 3% Granule
10 kg
100+300
14
Thiamethoxam 1% +Bifenthrin 0.5% Granule
10 kg
100+50
15
Thiamethoxam 1%+Thiocyclam 3% Granule
10 kg
100+300
16
Imidacloprid 1% +Bifenthrin 0.5% Granule
10 kg
100+50
17
Imidacloprid 1%+Thiocyclam 3% Granule
10 kg
100+300
18
Chlorantraniliprole 0.5% Granule
10 kg
50
19
Clothianidin 1% Granule
10 kg
100
20
Thiamethoxam 1% Granule
10 kg
100
21
Imidacloprid 1% Granule
10 kg
100
22
Bifenthrin 0.5% Granule
10 kg
50
23
Thiocyclam Hydrogen Oxalate 3% Granule
10 kg
300
24
Untreated control
0
0
kg- killogram, h-hectare, DAS- Days After Sowing
Table 3: Efficacy of inventive synergistic ready mix against insect-pest of sugarcane crop
Treatment Number
Germination (%)
No. of shoots
% Increase of shoots
Early shoot
% Plant Damage by
% Plant damage
White grub
Page 37 of 44
per mrl
over Untreated Control
borer incidence (%)
Termite
by White grub
larvae per cubic feet
45 DAS
45 DAS
45 DAS
60 DAS
60 DAS
120 DAS
120 DAS
120 DAS
1
100.0
22.6
94.8
0.00
0.00
0.00
0.00
0.00
2
100.0
23.0
98.3
0.00
0.00
0.00
0.00
0.00
3
100.0
22.4
93.1
0.00
0.00
0.00
0.00
0.00
4
100.0
22.6
94.8
0.00
0.00
0.00
0.00
0.00
5
100.0
22.4
93.1
0.00
0.00
0.00
0.00
0.00
6
100.0
22.2
91.4
0.00
0.00
0.00
0.00
0.00
7
99.2
19.8
70.7
0.24
0.12
0.26
0.10
0.34
8
99.4
19.6
69.0
0.22
0.14
0.32
0.12
0.46
9
98.4
18.4
58.6
0.32
0.16
0.42
0.16
0.52
10
95.2
18.2
56.9
0.42
2.64
3.62
0.68
1.42
11
92.4
16.4
41.4
0.26
2.86
3.42
0.72
1.84
12
95.6
17.4
50.0
1.24
0.18
0.32
0.18
0.28
13
98.2
19.8
70.7
1.20
0.22
0.42
0.24
0.32
14
90.2
17.2
48.3
1.62
0.18
0.38
0.20
0.42
15
96.4
19.4
67.2
1.24
0.14
0.26
0.16
0.62
16
88.4
18.2
56.9
2.44
0.18
0.34
0.42
1.12
17
90.2
17.4
50.0
1.46
0.22
0.28
0.62
1.26
18
88.6
15.6
34.5
1.64
3.60
4.20
1.28
2.64
19
92.4
18.4
58.6
1.48
0.40
0.68
0.20
0.58
20
93.2
18.2
56.9
1.24
0.32
0.72
0.22
0.72
21
86.4
15.6
34.5
1.82
0.86
0.92
0.36
0.82
22
80.2
14.6
25.9
2.84
2.86
3.62
1.12
2.46
23
84.2
13.8
19.0
1.66
2.40
4.23
1.42
2.86
24
78.4
11.6
0.0
3.24
3.82
5.28
1.82
3.28
DAS- Days After Sowing, mrl-meter row length
The field trial results presented in table 3 shows synergistic activity between three active ingredient of chlorantraniliprole+clothianidin+ bifenthrin, chlorantraniliprole + clothianidin+ thiocyclam hydrogen oxalate, chlorantraniliprole+thiamethoxam+ bifenthrin, chlorantraniliprole+ thiamethoxam+ thiocyclam hydrogen oxalate, 5 chlorantraniliprole + Imidacloprid+ bifenthrin, chlorantraniliprole + Imidacloprid+thiocyclam hydrogen oxalate by giving excellent germination (100%), about >90 % increase in shoots cane over control, excellent protection against early shoot borer (no incidence), excellent protection against termite with longer residual control (up to 120 days) and excellent protection against white grub 10
Page 38 of 44
damage (no damage). The visible characters were observed were increase in number of roots (root mass), more number of secondary and tertiary roots, dark green color of leaf, increased leaf blades width, leaf shinning, stem girth, plant/ shoot height and no lodging compared to other treatments. ,CLAIMS:CLAIMS We claim [CLAIM 1] An insecticidal composition comprising A) Chlorantraniliprole; B) insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid; C) further one more insecticide selected Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate and salts thereof; and one or more other inactive excipients. [CLAIM 2] The insecticidal composition as claimed in claim 1 wherein the component (A) Chlorantraniliprole is in ratio of 0.1-20%, component (B) insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid is in ratio of 0.1-30% and component (C) further one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate and salts thereof is in ratio of 0.1 to 50%. [CLAIM 3] The insecticidal composition as claimed in claim 1-2, wherein inactive excipients are selected from the group consisting of dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”), fillers, fillers and buffering agent.
[CLAIM 4] The insecticidal composition as claimed in claim 3, wherein inactive excipients are selected from Zinc Sulphate Monohydrate (ZnSO4,H2O), Zinc Sulphate Heptahydrate (ZnSO4,7H2O ), Zinc Gluconate, Zinc Lactate Gluconate, Sulphur, humic acid (sodium salt
Page 40 of 44
or potassium salt, Ammonium humate, Potassium humate), fulvic acid (Potassium fulvate, Zinc Fulvate), protein hydrolysate (N containing organic compounds), amino acids and peptides, seaweed extract (Ascophyllum nodosum), microbial extract, plant extract, vitamin B, chitin, chitosan and microbial inoculants, VAM (Vesicular Arbuscular Mycorrhiza) (Glomus fasciculatum), fungus. [CLAIM 5] The insecticidal composition as claimed in claim 1-4, wherein the formulations comprises of Granules (GR) or Zeon Concentrate (ZC) formulation. [CLAIM 6] The insecticidal composition as claimed in claim 5, wherein the Granules (GR) formulation comprises: a) component (A) Chlorantraniliprole is in ratio of 0.1-20%, component (B) insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid is in ratio of 0.1-30% and component (C) further one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate and salts thereof is in ratio of 0.1 to 50%; b) polyaryl phenol ethoxylate & calcium dodecyl benzene solphonate Blend; c) phosphoric acid; d) azo dye; e) diacetone alcohol; f) china clay; g) river sand. [CLAIM 7] The insecticidal composition as claimed in claim 5, wherein, the Zeon Concentrate (ZC) formulation comprises:
Page 41 of 44
a) component (A) Chlorantraniliprole is in ratio of 0.1-20%, component (B) insecticide selected from Clothianidin, Thiamethoxam and Imidacloprid is in ratio of 0.1-30% and component (C) further one more insecticide selected from Bifenthrin, Cartap Hydrochloride, Chlorpyrifos, Lambda Cyhalothrin and Thiocyclam Hydrogen Oxalate and salts thereof is in ratio of 0.1 to 50%; b) Acralic graft polymer; c) Fatty alcohol Ethoxylated; d) MonoEthyleneGlycol; e) Sodium salt of naphthalene sulfonate condensate; f) 1, 2- benzisothiazolin-3-one; g) Toluene Diisocynate; h) Polymethyl polyphenyl Isocynate; i) Mixture of heavy Aromatic Hydrocarbons; j) Silicon Dioxide; k) Polyaryl phenol ethoxylate; l) Modified styrene acrylic polymer; m) Xanthan powder; n) Silicone Antifoam. [CLAIM 8] The insecticidal composition as claimed in any of the preceding claims, wherein the said composition is to be used to manage or control Insect-pests in the crops selected from GMO (Genetically Modified Organism) and Non GMO varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Maize (Zea mays), Sorghum (Sorghum bicolor), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum) , Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus) , Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame
Page 42 of 44
(Sesamum indicum), Castor (Ricinus communis), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum) , Sapota (Manilkara zapota), Tea (Camellia sinensis), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum). [CLAIM 9] The insecticidal composition as claimed in any of the preceding claims, wherein the said composition control pests and insects from the order of the insects from the order of the Lepidoptera, for example Agrotis ypsilon, Chilo auricilius, Chilo infuscatellus, Chilo partellus, Chilo sacchariphagus, Chilo suppressalis, Cnaphalocrocis medinalis, Cydia pomonella, Earias vittella, Earias insulana, Exelastis atomosa, Helicoverpa armigera, Helicoverpa virescens, Helicoverpa zea, Hellula undalis, Leucinodes orbonalis, Maruca vitrata, Maruca testulalis, Mythimna separata, Pectinophora
Page 43 of 44
gossypiella, Phyllocnistis citrella, Pieris bras-sicae, Plutella xylostella, Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, Sesamia inferens, Sitotroga cerealella, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Trichoplusia ni, Tryporyza novella, Tuta absoluta. Beetles (Coleoptera), for example Diabrotica spp. Epila-chna varivestis, Holotrichia consanguinea, Holotrichia serrata, Leptinotarsa decemlineata, flies, mosquitoes (Diptera), e.g. Atherigona orientalis, Dacus cucurbi-tae, Dacus oleae, Liriomyza sativae, Liriomyza trifolii, Melanagromyza obtuse, thrips (Thysanoptera), e.g. Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Scirtothrips dorsalis, Thrips oryzae, Thrips palmi and Thrips tabaci, termites (Isoptera), e.g. Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis. true bugs (Hemiptera), e.g. Acyrtho-siphon pisum, Amrasca biguttula biguttula, Amrasca devastans, Amritodus atkinsoni, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gossypii, Aphis crassivora, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Aulacorthum solani, Bemisia argentifolii, Bemisia tabaci, Brevicoryne brassicae, Clavigralla gibbosa, Dysdercus cingulatus, Empoasca fabae, Macrosiphum euphorbiae, Myzus persicae, Nilaparvata lugens, Nephotettix virescens, Nephotettix nigropictus, Planococcus spp., Pseudococcus spp., Pyrilla perpusilla, Psylla mail, Psylla piri, Saccharicoccus sacchari, Sogatella furcifera, Trialeurodes vaporariorum, Toxoptera aurantiia, Psylla spp., Rhopalosiphum spp., Sitobion spp.