DESC:FIELD OF THE INVENTION
[0001] The present invention relates to an insecticide composition and a process for preparing the same.
BACKGROUND OF THE INVENTION
[0002] The background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Pest infestations pose significant adverse effect on economically important agricultural crops such as cotton, brinjal, okra, tomato, chilli, soybean, chick pea and cabbage. Particularly, cotton an important fiber and cash crop and chilli a spices crop which plays a dominant role in the industrial and agricultural economy are infested by major insects such as sucking insects which includes thrips, aphids, whiteflies and jassids and caterpillars such as helicoverpa, spodoptera and pink bollworm.
[0004] To address this problem, researchers are trying to produce an extensive variety of active ingredients and active ingredients formulations effective in the control of insects. Chemical insecticides of many types have been disclosed in the art and a large number are in commercial use. In crop protection, it is desirable in principle to increase specificity and reliability of action of insecticidal active ingredients.
[0005] Imidacloprid, emamectin benzoate, ethion, fenpropathrin, fipronil, dimethoate, lambda cyhalothrin, methomyl, spinosad, thiacloprid, diafenthiuron, thiamethoxam, novaluron, lufenuron are compounds independently known in the art for their insecticidal potency. They are disclosed in ‘The Pesticide Manual’ 15th Edition, published 2009 by the British Crop Protection Council, and are also commercially available.
[0006] Two way combination of diafenthiuron with acetamiprid, fipronil with acetamiprid, emamectin benzoate with fipronil are known in the art and are in commercial use.
[0007] However, certain insect pests are becoming more and more resistant to a number of most widely used insecticides available in the art. Thus, on one hand even more stringent conditions are being placed on the type and use rate of insecticide, while on the other hand approved insecticides are becoming less and less effective over time in insect pests available in the art.
[0008] Furthermore, it is very expensive and time consuming to seek and obtain registration of a new insecticide compound, including its proposed use rate. Approval data required must not only include evidence of efficacy at the application rates proposed but also safety of insecticide when applied at the recommended level, also the recommended level of insecticide that may be applied per unit of area is under pressure from governmental, as well as for economic and environmental reasons.
[0009] Accordingly, demonstration of synergism by combination of existing insecticide agents, permits use of individual agents of synergistic combination at lower rates than when used alone, and in many instances ameliorates increasing resistance to insecticidal effectiveness.
[0010] Thus, there is a great need in the art for environmentally safe, stable, synergistic, broad-spectrum, better efficacious, insecticide composition comprising combination of three active ingredients having different mode of action, showing one or more of advantage such as stability, synergistic effect, faster onset of insecticide action, a broad-spectrum and long-lasting action, reduced dosage of active ingredients, reduced application rate of the insecticide thereby rendering such combination environmentally safe, and reduce or delay the development of resistance in pests, which is necessary to obtain acceptable insect pest control and a process for preparing such insecticide composition or formulation comprising the same.
SUMMARY OF THE INVENTION
[0011] The present invention provides an insecticide composition comprising emamectin benzoate, acetamiprid and lambda-cyhalothrin and inactive excipients
[0012] The present invention provides an insecticide composition comprising emamectin benzoate, acetamiprid and lambda-cyhalothrin and inactive excipients consisting of a dispersing agent, an emulsifier, a pH modifier, a co-solvent and a solvent.
[0013] The insecticide composition comprises emamectin benzoate in an amount of from 0.1% to 30 % w/w, acetamiprid in an amount of from 0.1% to 40% w/w and lambda-cyhalothrin in an amount of from 0.1% to 25% w/w, dispersing agent in an amount of from 0.01% to 9% w/w, an emulsifier in an amount of from 0.3% to 28 % w/w, a pH modifier in an amount of from 0.01% to 5% w/w, a co-solvent in an amount of from 0.01 % to 35% w/w and a solvent in an amount of from 1.0% to 95% w/w.
[0014] The insecticide composition of the present invention is formulated in a number of ways for suitable application. Examples of suitable formulations include water-dispersible granule (WDG), a water-soluble granule (SG), a wettable powder (WP), a water-dispersible powder (WDP), a water-soluble powder (SP), a granule (GR), an encapsulated granule (CG), a fine granule (FG), a macrogranule (GG), a microgranule (MG), a suspension concentrate (SC), a water-soluble concentrate (SL), an emulsifiable concentrate (EC), an emulsion (EW), a micro-emulsion (ME), a flowable suspension (FS), a suspoemulsion (SE), ZC formulation (ZC), soil applied granules (SAG), dustable powder (DP), a gel, a water-dispersible tablet (WT), an oil-dispersion (OD), a dispersible concentrate (DC) or a microencapsulated suspension (CS).
[0015] The insecticide composition of the present invention is preferably formulated as a dispersible concentrate (DC).
[0016] The present invention provides a process for preparing the insecticide composition. The process comprises mixing emamectin benzoate, acetamiprid and lambda-cyhalothrin.
[0017] Preferably, the present invention provides a process for preparing dispersible concentrate (DC) formulation comprising the steps of
a) mixing the inactive excipients to obtain a solution;
b) adding emamectin benzoate, acetamiprid and lambda-cyhalothrin to the solution and continuing to mix to obtain a transparent homogeneous solution; and
c) filtering the transparent homogeneous solution to obtain the dispersible concentrate (DC).
[0018] Various objects, features, aspects and advantages of the inventive subject matter will become more apparent from the following detailed description of preferred embodiments.
DETAILED DESCRIPTION OF THE INVENTION
[0019] The following is a detailed description of embodiments of the present disclosure. The embodiments are in such detail as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims.
[0020] Unless the context requires otherwise, throughout the specification which follow, the word “comprise” and variations thereof, such as, “comprises” and “comprising” are to be construed in an open, inclusive sense that is as “including, but not limited to.”
[0021] Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
[0022] As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the content clearly dictates otherwise. It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.
[0023] In some embodiments, the numbers expressing quantities of ingredients, properties such as concentration, process conditions, and so forth, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term “about.” Accordingly, in some embodiments, the numerical parameters set forth in the written description are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.
[0024] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein.
[0025] All methods described herein is performed in suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g. “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
[0026] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments.
[0027] The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus, if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.
[0028] The present invention does not use any ‘biological materials’ that is the materials which are capable of reproducing itself or being reproduced in a biological system.
[0029] The present disclosure provides an insecticide composition comprising emamectin benzoate, acetamiprid and lambda-cyhalothrin.
[0030] Emamectin benzoate chemically known as (4?R)-4?-deoxy-4?-(methylamino) avermectin B1 benzoate (1:1) is an avermectin insecticide. It is a contact insecticide with negligible toxicity to non-target organisms. It allosterically activates glutamate-gated chloride channels (GluCls), causing paralysis in the insects.
[0031] Acetamiprid chemically known as (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide is a pyridylmethylamine, neonicotinoid insecticide. It is a systemic insecticide and it acts by binding to the acetylcholine site on nicotinoyl acetylcholine receptors (nAChRs), causing a range of symptoms from hyperexcitation to lethargy and paralysis in the insects.
[0032] Lambda-cyhalothrin chemically known as (R)-cyano(3-phenoxyphenyl)methyl (1S,3S)-rel-3-[(1Z)-2-chloro-3,3,3-trifluoro-1-propen-1-yl]-2,2-dimethylcyclopropanecarboxylate is a pyrethroid ester insecticide. It is a contact insecticide and it acts by disrupting the gating mechanism of sodium channels that are involved in the generation and conduction of nerve impulses, causing rapid paralysis and death of the insects.
[0033] Emamectin benzoate controls the insects of the order lepidoptera which include caterpillars such as helicoverpa and spodoptera. Acetamiprid controls the insects of the order homoptera which include sucking pests such as whiteflies, aphids and jassids. Lambda-cyhalothrin controls the insects of the order lepidoptera which include caterpillar pink bollworm and insects of the order homoptera which include sucking pest thrips. By combining emamectin benzoate, acetamiprid with lambda-cyhalothrin the broad spectrum of insects of both the orders, order lepidoptera which include caterpillars such as helicoverpa, spodoptera, pink bollworm and order homoptera which include sucking pests such as thrips, jassids, aphids, and whiteflies are controlled at one time. Therefore, the present invention is based upon a surprising finding that the combination of the above described three active components displays a synergistic insecticidal effect in controlling broad spectrum of insects when applied in combination comprising all three active ingredients.
[0034] The synergistic effects of the combination of emamectin benzoate, acetamiprid and lambda-cyhalothrin will provide one or more of a number of advantages over the use of each active ingredient alone. In particular, the rate of application of each active ingredient is markedly reduced, when the three compounds are used in combination, while maintaining a high level of insecticidal efficacy. Especially, the use of the combination of emamectin benzoate, acetamiprid and lambda-cyhalothrin has the potential to control insects at a low application rate, in particular at a rate of application at which the individual active ingredients alone are less effective. A treatment using the combination of emamectin benzoate, acetamiprid and lambda-cyhalothrin controls a wider variety of insect pests compared to the compounds when used alone. The use of a composition comprising the three aforementioned active ingredients also has a speed/onset of action which is faster than that which would have been predicted from the speed/onset of action of each ingredient used individually and in combination of two ingredients. Also, the synergistic effect allow a long-lasting action, better control of broad spectrum of insects with only one or a few applications, and a broadening of possible application period.
[0035] The insecticide composition according to the present disclosure is advantageous in the protection of crops such as cotton, brinjal, okra, tomato, chilli, soybean, chick pea and cabbage. Preferably, cotton and chilli crop.
[0036] The insecticide composition is applied to the insects in a variety of ways, at various application timing and at various concentrations. The insecticide composition is applied to the insects by foliar application. The application of the insecticide composition is done on the crops from vegetative phase to reproductive phase.
[0037] The total application rate of emamectin benzoate, acetamiprid and lambda-cyhalothrin varies and covers a wide range, for example from 1 to 500g/ml per hectare (g/ml/ha). Preferably, the application rate ranges from 450 to 500 g/ml per hectare.
[0038] According to embodiments, the insecticide composition disclosed herein is applied in a single treatment or in several treatments (sequential application).
[0039] The amount of active ingredients emamectin benzoate, acetamiprid and lambda-cyhalothrin present in the composition covers a wide range. In some preferred embodiments, the composition comprises, by weight, from 0.1-30% of emamectin benzoate, from 0.1-40% of acetamiprid and from 0.1 -25.0 % of lambda-cyhalothrin. In preferred embodiments, the total amount of emamectin benzoate, acetamiprid and lambda-cyhalothrin in the composition range from 0.3% to 95% by weight of the composition.
[0040] The insecticide composition of the present disclosure is formulated by mixing emamectin benzoate, acetamiprid and lambda-cyhalothrin. In an embodiment the mixture of emamectin benzoate, acetamiprid and lambda-cyhalothrin is mixed with inactive excipients. Suitable excipients will depend upon such factors as the type of formulation and the manner of the end use of the formulation, and will be known to a person skilled in the art. In some preferred embodiments, the one or more inactive excipients are selected from dispersing agent, an emulsifier, a pH modifier, a co-solvent, a solvent, an anti-crystalline agent, a wetting agent, a rheology modifier, a spreading agent, an inert carrier, a stabilizing agent, an anti-caking agent, an anti-foaming agent, an antioxidant, a biocide, an anti-freezing agent and a combination thereof.
[0041] In a specific preferred embodiments, the inactive excipients consist of a dispersing agent, an emulsifier, a pH modifier, a co-solvent and a solvent.

[0042] The dispersing agent is selected from sulfonates of condensed naphthalene, naphthalene formaldehyde condensates, alkoxylated linear alcohols, sodium alkyl benzene sulfonates, ammonium salts of sulfonated naphthalene, lignosulphonates, phenyl naphthalene sulphonates, ethoxylated alkyl phenols, ethoxylated fatty acids, polyaromatic sulfonates, sodium alkyl aryl sulfonates, maleic anhydride copolymers, phosphate esters, condensation products of aryl/alkyl sulphonic acids and formaldehyde, addition products of ethylene oxide and fatty acid esters, polycarboxylates, alkali earth metal salt of alkylbenzene sulfonate, calcium dodecylbenzene sulfonate, salts of sulfonated naphthalene, polystyrenated acrylated co- polymer, salts of polyacrylic acids, salts of phenol sulfonic acids and mixtures thereof. The dispersing agent is present in an amount of from 0.01% to 9.0% by weight based on a total weight of the composition.
[0043] Suitable emulsifier for use in the formulation includes all substances which normally can be used for this purpose in agrochemical formulations. Examples of the excipient include substances which can be ionic or non-ionic emulsifier or surfactant. The ionic substances can be selected from cationic surfactants, or anionic surfactants and a combination thereof.
[0044] The ionic emulsifier or surfactant can be selected from the group consisting of but not limiting to calcium salt of alkylaryl sulfonates, calcium dodecylbenzene sulfonate, ethoxylated and/or propoxylated di- or tri-styrylphenol phosphate, ethoxylated and/or propoxylated di- or tri-styrylphenol sulfate, phenyl sulfonate, alkynaphtalenesulphonate ethoxylated and/or propoxylated alcohol phosphate ester, ethoxylated and/or propoxylated alkylaryl phosphate ester, suphosuccinate, salts of polyacrylic acids, salts of lignosulphonic acid, salts of phenylsulphonic or naphthalenesulphonic acids, sulphosuccinic ester salts, taurine derivatives, especially alkyl taurates, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols, phosphoric esters of polyethoxylated phenols or alcohols polycarboxylate and mixtures thereof.
[0045] The non-ionic emulsifier or surfactant can be selected from the group consisting of but not limiting to alkoxylated alcohols, ethoxylated alcohols, ethoxylated propoxylated alcohols, alkylphenolethoxylates, alkoxylated tristyrylphenols, tristyryphenol ethoxylate, alkoxylated tributylphenols, alkylaminethoxylates, ethoxylated propoxylated polyaryl phenol, ethoxylated poly adducts of ethylene oxide and propylene oxide, ethoxylated fatty acids, sorbitan esters and their ethoxylates, sorbitol esters, propylene glycol esters of fatty acids and polyglycerol esters, ethoxylated ricinoleic acid triglycerides castor oil ethoxylate and mixtures thereof. The emulsifier is present in an amount of from 0.3% to 28 % by weight based on a total weight of the composition.
[0046] The pH modifier is selected from sodium silicate, potassium silicate, magnesium silicate, manganese silicate, sodium pyrophosphate, sodium acetate, sodium oxalate, sodium carbonate, sodium bicarbonate, sodium bentonite, sodium acetate, attapulgite, diatomaceous earth, sodium zeolite, trisodium phosphate, trisodium citrate, magnesium carbonate, magnesium sulphate, monoethanol amine, triethanol amine, triethylamine, dibasic esters selected from dimethyl succinate, dimethyl glutarate, dimethyl adipate , ortho phosphoric acid, oxalic acid, citric acid, hydrochloric acid and mixtures thereof. The pH modifier is present in an amount of from 0.01% to 5% by weight based on a total weight of the composition.
[0047] Suitable co-solvents are selected from the group comprising of solvent naphtha (heavy, medium, light), turpentine oil, xylene, toluene, 1,2,4-trimethylbenzene(pseudocumene) and mixtures thereof. The co-solvent is present in an amount of from 0.01 % to 35% by weight based on a total weight of the composition.
[0048] Suitable solvents for use in the composition are selected from all customary organic solvents which dissolve one or more of the active ingredients employed. Suitable organic solvents for the compounds emamectin benzoate, acetamiprid and lambda-cyhalothrin are known in the art. Preferred solvents include, but not limited to, deionized (DI) water, N-alkyl pyrrolidone, N-methyl-2-pyrrolidone, dimethylformamide (DMF), dimethylsulfoxide (DMSO) and mixtures thereof. The solvent is present in an amount of from 1.0% to 95% by weight based on a total weight of the composition.
[0049] The anti-crystalline agent is selected from vinyl pyrrolidone polymer, polyvinyl alcohol, sodium polyacrylate co-polymer and mixtures thereof. The anti-crystalline agent is present in an amount of from 0 % to 10% by weight based on a total weight of the composition.
[0050] The wetting agent is selected from alkyl phenol ethoxylate, fatty oil ethoxylate, phenyl naphthalene sulphonates, alkyl naphthalene sulfonates, sodium alkyl naphthalene sulfonate, sodium salt of sulfonated alkyl carboxylate, dioctyl sulfosuccinate sodium salt, polyoxyalkylated ethyl phenols, polyoxyethoxylated fatty alcohols, polyoxyethoxylated fatty amines, lignin derivatives, alkane sulfonates, alpha olefin sulfonates, alkylbenzene sulfonates, salts of polycarboxylic acids, salts of esters of sulfosuccinic acid, octyl phenol ether sulphate, anionic phosphate esters, disodium laureth sulfosuccinate, diisodecyl sodium sulfosuccinate, alkylnaphthalenesulfonates, alkylbenzenesulfonates, alkylpolyglycol ether sulfonates, alkyl ether phosphates, alkyl ether sulfates and alkyl sulfosuccinic monoesters, and mixtures thereof. The wetting agent is present in an amount of from 0 % to 15% by weight based on a total weight of the composition.
[0051] The rheology modifier is selected from hydrophobic silica, fume silica, bentonite, diatomaceous earth, montmorillonite, attapulgites or hydroxymethyl cellulose, xanthan gum, polyvinyl alcohol, and its derivatives, derivative of hectorite clay, benton, thickening silica, hydrated clay minerals, magnesium aluminium silicates and mixtures thereof. The rheology modifier is present in an amount of from 0 % to 15% by weight based on a total weight of the composition.
[0052] Suitable spreading agents are selected from the group comprising of polyoxyethylene alkyl ether, trisiloxane ethoxylate, polysorbates, ethoxylated tristyrylphenol phosphate, sodium lauryl sulphate, sodium methyl oleoyl taurate and mixtures thereof. The spreading agents is present in the composition in an amount ranging from 0 to 15 % w/w.
[0053] Suitable inert carrier(s) for use in the composition include, but not limited to, natural ground minerals, such as kaolin or china clay, alumina, talc, chalk, quartz, attapulgite, montmorillonite, and diatomaceous earth, or synthetic ground minerals, such as highly dispersed silicic acid, aluminium oxide, silicates, and calcium phosphates and calcium hydrogen phosphates, crushed and fractionated natural minerals, such as calcite, marble, pumice, precipitated silica, sepiolite, bentonite, river sand, zeolites, starch, sand, talc, quartz, dolomite, synthetic granules of inorganic and organic ground materials and mixtures thereof. The inert carrier is present in an amount of from 0% to 90% by weight based on a total weight of the composition.
[0054] The stabilizing agent is selected from modified hydrophobic silica, colloidal silica, precipitated silica, hydrophobic silica powder and mixtures thereof. Preferably, the stabilizing agent is dimethyldichlorosilane treated fumed silica. In another embodiment, the stabilizing agent is selected fromgamma butyrolactone, butylated hydroxyl toluene and its derivatives, epichlorhydrin, quinone derivatives, hydrazine hydrates and its derivatives, general class UV stabilizers, glycols and its derivatives and mixtures thereof. The stabilizing agent is present in an amount of from 0 to 8% by weight based on a total weight of the composition.
[0055] The anti-caking agent is selected from kaolin clay, precipitate silica, colloidal silica, fumed silica, talc, gypsum, silicates, calcium carbonate, magnesium carbonate, magnesium sulfate, and mixtures thereof. The anti-caking agent is present in an amount of from 0 to 5% by weight based on a total weight of the composition.
[0056] Suitable anti-foaming agents for use in the composition include all substances which normally be used for this purpose in agrochemical compositions. Particularly preferred anti-foaming agents polydimethylsiloxanes, perfluoroalkylphosphonic acids and mixtures thereof. The anti-foaming agent is present in an amount of from 0 to 5% w/w by weight based on a total weight of the composition.
[0057] Suitable antioxidants are all substances which normally be used for this purpose in agrochemical compositions, as is known in the art. Preferred antioxidant is butylated hydroxytoluene. The antioxidant is present in an amount of from 0 to 5% w/w by weight based on a total weight of the composition.
[0058] The biocide is selected from 1,2-benzisothiazolin-3-one, formaldehyde and mixtures thereof. The biocide is present in an amount of from 0 to 1% by weight based on a total weight of the composition.
[0059] Suitable anti-freezing agents include organic solvents which are completely miscible with water, such as ethylene glycol, propylene glycol, other glycols, glycerine urea and mixtures thereof. The anti-freezing agent is present in the composition in an amount of from 0 to 12% w/w.
[0060] In one specific embodiment the composition comprises emamectin benzoate in an amount of from 0.1% to 30 % w/w, acetamiprid in an amount of from 0.1% to 40% w/w and lambda-cyhalothrin in an amount of from 0.1% to 25% w/w, dispersing agent in an amount of from 0.01% to 9% w/w, an emulsifier in an amount of from 0.3% to 28% w/w, a pH modifier in an amount of from 0.01% to 5% w/w, a co-solvent in an amount of from 0.01 % to 35% w/w and a solvent in an amount of from 1.0% to 95% w/w.
[0061] According to embodiments of the present disclosure, the insecticide combination exists as mixed formulations of emamectin benzoate, acetamiprid lambda-cyhalothrin and inactive excipients, which is then used in a conventional way by diluting with water or prepared as tank mixes by jointly diluting separately formulated or partially separately formulated active ingredients with water or with aqueous solutions.
[0062] In various embodiments, the insecticide composition comprising the combination of emamectin benzoate, acetamiprid and lambda-cyhalothrin is formulated in liquid or solid form. In preferred embodiments, the disclosed insecticide composition is formulated as a water-dispersible granule (WDG), a water-soluble granule (SG), a wettable powder (WP), a water-dispersible powder (WDP), a water-soluble powder (SP), a granule (GR), an encapsulated granule (CG), a fine granule (FG), a macrogranule (GG), a microgranule (MG), a suspension concentrate (SC), a water-soluble concentrate (SL), an emulsifiable concentrate (EC), an emulsion (EW), a micro-emulsion (ME), a flowable suspension (FS), a suspoemulsion (SE), ZC formulation (ZC), soil applied granules (SAG), dustable powder (DP), a gel, a water-dispersible tablet (WT), an oil-dispersion (OD), a dispersible concentrate (DC) or a microencapsulated suspension (CS).
[0063] In a preferred embodiment, the insecticide composition comprising the combination of emamectin benzoate, acetamiprid and lambda-cyhalothrin is formulated as a dispersible concentrate (DC).
[0064] The dispersible concentrate (DC) is a stable homogeneous liquid which is free from visible suspended matter and sediment, and is applied as dispersion after dilution in water.
[0065] In one embodiment, the dispersible concentrate (DC) comprises:
a) 0.1 – 30.0% w/w emamectin benzoate;
b) 0.1% to 40.0% w/w acetamiprid;
c) 0.1% to 25.0% w/w lambda-cyhalothrin;
d) 0.01 - 9.0% w/w dispersing agent;
e) 0.3 – 28.0% w/w emulsifier;
f) 0.01 – 5.0% w/w pH modifier;
g) 0.01– 35.0% w/w co-solvent; and
h) 1.0% to 95.0% w/w solvent.
[0066] In a specific embodiment, the dispersible concentrate (DC) comprises:
a) 0.1 – 30.0% w/w emamectin benzoate;
b) 0.1% to 40.0% w/w acetamiprid;
c) 0.1% to 25.0%w/w lambda-cyhalothrin;
d) 0.01 - 9.0% w/w dispersing agent is selected from the group comprising of calcium dodecylbenzene sulfonate, polystyrenated acrylated co- polymer, salts of polyacrylic acids, and mixtures thereof;
e) 0.3 – 28.0% w/w emulsifier is selected from the group comprising of,ethoxylated propoxylated alcohols, tristyryphenol ethoxylate, ethoxylated propoxylated polyaryl phenol, ethoxylated poly adducts of ethylene oxide and propylene oxide, propylene glycol esters of fatty acids and polyglycerol esters, and mixtures thereof;
f) 0.01 – 5.0% w/w pH modifier is selected from the group comprising of sodium acetate, trisodium phosphate, trisodium citrate, ortho phosphoric acid, oxalic acid, citric acid, and mixtures thereof;
g) 0.01 – 35.0% w/w co-solvent is selected from the group comprising of solvent naphtha (heavy, medium, light), 1,2,4-trimethylbenzene(pseudocumene), and mixtures thereof; and
h) 1.0% to 95.0% w/w solvent is selected from the group comprising of deionized (DI) water, N-alkyl pyrrolidone, N-methyl-2-pyrrolidone, dimethylformamide (DMF), dimethylsulfoxide (DMSO), and mixtures thereof.
[0067] In a more specific embodiment, the dispersible concentrate (DC) comprises
a) emamectin benzoate in an amount of 2.2% w/w;
b) acetamiprid in an amount of 4.0% w/w;
c) lambda-cyhalothrin in an amount of 5.0% w/w;
d) calcium dodecylbenzene sulfonate in an amount of 3.0% w/w,
e) ethoxylated propoxylated polyarylphenol in an amount of 12% w/w,
f) ortho phosphoric acid in an amount of 0.8% w/w,
g) solvent naphtha in an amount of 8.0% w/w; and
h) N-methyl-2-pyrrolidone in an amount of 65% w/w.
[0068] The present disclosure further provides a process for preparing the insecticide composition described herein. The insecticide composition is prepared by mixing the respective active compounds and the inactive excipients.
[0069] In one embodiment, the present disclosure provides a process for preparing the dispersible concentrate (DC) comprising the steps of:
a) mixing the inactive excipients to obtain a solution;
b) adding emamectin benzoate, acetamiprid and lambda-cyhalothrin to the solution and continuing to mix to obtain a transparent homogeneous solution; and
c) filtering the transparent homogeneous solution to obtain the dispersible concentrate (DC).

[0070] In a specific embodiment, the inactive excipients consist of a dispersing agent, an emulsifier, a pH modifier, a co-solvent and a solvent.
[0071] The present disclosure is further explained in the form of following examples. However, it is to be understood that the foregoing examples are merely illustrative and are not to be taken as limitations upon the scope of the invention. Various changes and modifications to the disclosed embodiments will be apparent to those skilled in the art. Such changes and modifications may be made without departing from the scope of the invention.
EXAMPLES
[0072] Example 1: Insecticide composition of the present invention is shown below in Table A.
Table A
Ingredients Concentration (% w/w)
Emamectin benzoate 0.1 – 30.0
Acetamiprid 0.1 – 40.0
Lambda-cyhalothrin 0.1 – 25.0
Dispersing agent 0.01 - 9.0
Emulsifier 0.3 – 28.0
pH modifier 0.01 – 5.0
Co-solvent 0.01 – 35.0
Solvent 1.0 – 95.0

[0073] Dispersible concentrate (DC) formulation of the present invention is shown below in Table B.
Table B
Ingredients Example 2 Example 3 Example 4
% w/w % w/w % w/w
Emamectin benzoate 2.2 1.0 3.0
Acetamiprid 4.0 3.0 5.5
Lambda-cyhalothrin 5.0 7.5 4.0
Calcium dodecylbenzene sulfonate 3.0 2.8 3.3
Ethoxylated propoxylated polyarylphenol 12.0 12.2 11.7
Ortho phosphoric acid 0.8 0.5 0.6
Solvent naphtha 8.0 8.0 8.0
N-methyl-2-pyrrolidone QS QS QS
Total 100.00 100.00 100.00

[0074] The process for preparing the dispersible concentrate (DC) formulation comprises the steps as below.
[0075] N-methyl-2-pyrrolidone which is a water miscible solvent and solvent naphtha which is a water immiscible co-solvent along with pH modifier ortho phosphoric acid, dispersing agent calcium dodecylbenzene sulfonate and emulsifier ethoxylated propoxylated polyarylphenol as mentioned in Examples 2 to 4 were mixed by stirring for 15 minutes to obtain a solution. The active ingredients, emamectin benzoate, acetamiprid and lambda-cyhalothrin were added to the solution and stirring was continued to mix for 1 to 2 hours until the active ingredients were completely dissolved and a clear and transparent homogenous solution was obtained. The homogeneous solution was filtered to remove any extraneous matter to obtain the dispersible concentrate (DC) having the pH ranging from 3.0 to 6.0, particularly 3.7 to 4.8.
[0076] According to the FAO (Food and Agricultural Organization)/WHO manual, the “accelerated storage test” is considered as an indicative of product stability. That is accelerated storage test data provides an indication that the product is stable for at least two years at ambient temperature. Further, the FAO/WHO manual indicates storage at 54°C ± 2°C for 14 days as the default test conditions.
[0077] The “ambient sample” is the sample at the room temperature which is before subjecting to the accelerated storage test.
[0078] The ambient samples of the dispersible concentrate (DC) formulation of the above examples were subjected to the accelerated storage test to find out the product stability.
[0079] Table 1 shows the physical and chemical properties of the dispersible concentrate (DC) formulation, before and after the accelerated storage test. The dispersible concentrate (DC) formulation was prepared according to the above Example 2.
S. No. Tests Product specifications Ambient sample
(before) Accelerated storage sample tested @ 54±2°c for 14 days
(after)
1 Appearance Cream to white color suspension Complies Complies
2 Active Ingredient /content test % w/w Emamectin benzoate
content
2.09 – 2.42 2.20 2.18
(0.5%)*
3 Acetamiprid content 3.80 – 4.40 4.00 3.96
(0.25%*)
4 Lambda cyhalothrin
content 4.75 – 5.50 5.00 4.99
(0.2%*)
5 Persistent Foam, mL Max. 60 15 14
6 Wet sieve passing through 45 micron % w/w Min. 98.0 99.98 99.98
7 pH of 1% aq. dispersion 3.0 – 6.0 4.15 4.20
8 Dispersion stability Time hr. Limits of stability
0 Initial dispersion completed Complies
Complies

0.5 No Cream and no sedimentation seen after 0.5 hours (creaming and sedimentation should not be more than 2 ml in 100 ml dilution). Nil
Nil

24.0 Re-dispersion completed Complies
Complies

24.5 No Cream and no sedimentation seen after 24.5 hours (creaming and sedimentation should not be more than 2 ml in 100 ml dilution). Nil Nil
9 Particle size distribution, µ d(10)
d(50)
d( 90) Max. 10 µ
0.39
1.68
3.07 0.37
1.72
3.10
10 Moisture content,% w/w Max. 1.0 0.42 0.42

[0080] The results in Table 1 show that the appearance of the ambient sample of the dispersible concentrate (DC) formulation before and after the accelerated storage test (@54±2°C for 14 days) remained the same that is ‘cream to white color suspension’.
[0081] Further, the content of emamectin benzoate, acetamiprid and lambda-cyhalothrin is found to be 2.20% w/w, 4.00% w/w, 5.00% w/w, respectively before subjecting the ambient sample to the accelerated storage test. After subjecting the ambient sample to the accelerated storage test (that is storing at 54±2°C for 14 days in the HDPE containers) the content of emamectin benzoate, acetamiprid and lambda-cyhalothrin is found to be almost same, that is 2.18% w/w, 3.96 % w/w, 4.99% w/w respectively. It indicates that the content of emamectin benzoate, acetamiprid and lambda-cyhalothrin is degraded only by 0.5%, 0.25 % and 0.2% respectively and falls within the product specification range and hence the content of the active ingredients in the composition is stable.
[0082] The active ingredients acetamiprid and lambda-cyhalothrin are stable in the acidic, alkaline and neutral pH, but the active ingredient emamectin benzoate is stable only in acidic pH ranging from 3.0 to 6.0, more specifically 3.7 to 4.8 and it degrades outside this pH range. Therefore, in the present invention pH modifier is added in the composition to alter and maintain the pH of the composition in the acidic pH ranging from 3.0–6.0, more specifically 3.7 to 4.8 to maintain the stability of the composition.
[0083] The pH of the ambient sample of the dispersible concentrate formulation before subjecting it to the accelerated storage test is found to be 4.15. However, even after subjecting the ambient sample to the accelerated storage test (that is storing at 54±2°C for 14 days in the HDPE containers) the pH is found to be almost same, that is 4.20. It indicates that the dispersible concentrate is adhering to the pH range of 3.0 – 6.0 and hence the formulation is stable.
[0084] Dispersion stability test is performed to ensure that a sufficient proportion of active ingredient is homogeneously dispersed in the spray liquid to give a satisfactory and effective mixture throughout spraying. The ambient sample and accelerated storage sample of the dispersible concentrate formulation, subjected to dispersion stability test did not show any cream or sedimentation even after 0.5 hours of the dispersion or 24.5 hours of the re-dispersion test.
[0085] Tests such as persistent foam and moisture content were conducted for the ambient sample of the dispersible concentrate (DC) formulation, before and after accelerated storage test. The results indicated that persistent foam test showed low persistent foam of 15 ml and 14 ml indicating the less froth formation and moisture content test showed low moisture content of 0.42% indicating no turbidity and no crystal growth formation in the formulation.
[0086] The ambient sample of the dispersible concentrate (DC) formulation was diluted in water and is tested for its particle size by particle size distribution test by using laser diffraction method using Malvern MS3000 and wet sieve passing test by using 45µ wet sieve. The particle size distribution test showed that particle size distribution of the ambient sample is d(10) is 0.39µ, d(50) is 1.68 µ and d(90) is 3.07µ and the particle size distribution of the accelerated storage sample was found to be almost same that is d(10) is 0.37µ, d(50) is 1.72 µ and d(90) is 3.10µ and wet sieve passing test showed passing of 99.98 %w/w of particles of the formulation through the 45µ wet sieve indicating the low particle size (d(90) is 3.10µ) of the formulation. Therefore, both the tests confirm the low particle size (d(90) is 3.10µ) and no crystal growth after the accelerated storage test.
[0087] The particle size distribution of dispersible concentrates is directly related to the efficacy, dispersion stability, and required dosage of the combination. That is the smaller particle size (3.10 µ) of the dispersible concentrate of the present invention provide better dispersion stability, since small particle sizes enable the brownian motion to dominate over gravitational force, provides a larger specific surface area, which will further increase the dissolution rate, adhesion, and penetrability to the target pest, improving the efficacy and bioavailability of the formulation which leads to the increased insecticidal activity.
[0088] In view of the above test results, dispersible concentrate (DC) formulation of the present invention prepared in accordance with the above examples are extrapolated to be stable for 2 years.
[0089] The advantages of the dispersible concentrate compositions of the present invention include storage stability, reduced settling of the suspension during storage or on dilution, excellent adherence to its target surface, simple production process saves production and equipment costs, spray mixtures obtained from the dispersible concentrates have uniform distribution of the active substances, simple and easy handling for the users as the dilution is made with the desired amount of water. Also, as the DC formulation is diluted in water, it forms a stable dispersion of fine particles size of from 0.01 to 100. microns, more specifically 0.1 to 10 microns which lead to the improved bio-efficacy.
Example 5: Field Tests
[0090] The dispersible concentrate (DC) of Example 2 was tested for its biological activity and the results are shown in Tables 2 to 5 below:

Table 2: Field test results of the emamectin benzoate, acetamiprid, lambda-cyhalothrin dispersible concentrate (DC) applied against thrips in cotton at the Dehgam, Gujarat location in the Kharif season 2021.

Types Treatment Dosage Mean no. of thrips/ leaf
%
Reduction
over UTC
(16 DAA)
g a.i./ha Formulation (g/ml/ha) Before 16 DAA
Example 2
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(recommended dosage)
11 + 25 + 20 500 145.8 8.3 95.79
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(5% reduced recommended dosage) 10.45+ 23.75 + 19 475 144.8 9.5 95.08
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(10% reduced recommended dosage)

9.9 + 22.5 + 18 450 150.0 10.8 94.53
Individual ingredients
Emamectin benzoate 5%SG 11 220 149.8 111 43.74
Lambda-cyhalothrin 5%EC 25 500 146.8 88.2 55.29
Acetamiprid 20%SP

20 100 149.4 110.1 44.19
Conventional Combinations Diafenthiuron 40.1% + Acetamiprid 3.9%WP 250.63 + 24.38 625 151.8 95.1 51.79
Chlorantraniliprole 9.3%+ Lambda cyhalothrin 4.6% ZC 23.25 + 11.5 250 149.4 91.2 53.77
Acetamiprid 1.1%+ Cypermethrin 5.50% EC 11 + 55 1000 148.3 98.2 50.22
Untreated check - - 146.4 197.3 0
DAA- Days after application
[0091] As seen from the above results, 16 days after application of the insecticide composition comprising emamectin benzoate in an amount of 2.2%, acetamiprid in an amount of 4% and lambda-cyhalothrin in an amount of 5% at the application rate of 500, 475 and 450 g/ml per hectare (g/ml/ha) the thrips population was reduced to the greater extent that is 95.79%, 95.08% and 94.53 percent reduction of the thrips respectively in comparison to the untreated check.

[0092] The results were better in comparison to the individual compounds emamectin benzoate, acetamiprid and lambda-cyhalothrin. That is the registered formulation of emamectin benzoate 5%SG alone at the application rate of 220 g/ml per hectare showed only 43.74% reduction of the thrips. And the registered formulation of lambda cyhalothrin 5%EC alone at the application rate of 500 g/ml per hectare showed only 55.29% reduction of the thrips. Likewise, the registered formulation of acetamiprid 20%SP alone at the application rate of 100 g/ml per hectare showed only 44.19% reduction of the thrips.

[0093] Further, the results exhibited by the DC formulation of the present invention was better in comparison to the conventional formulations such as diafenthiuron 40.1% + acetamiprid 3.9%WP, chlorantraniliprole 9.3%+ lambda cyhalothrin 4.6% ZC and acetamiprid 1.1%+ cypermethrin 5.50%EC available in the market. That is diafenthiuron 40.1% + acetamiprid 3.9%WP, at the higher application rate of 625 g/ml per hectare showed only 51.79% reduction of the thrips which is 44% lesser than the thrips reduction of the present invention (95.79%). Further, chlorantraniliprole 9.3%+ lambda cyhalothrin 4.6% ZC at the application rate of 250 g/ml per hectare showed only 53.77% reduction of the thrips which is 42.02% lesser than the thrips reduction of the present invention (95.79%). Similarly, acetamiprid 1.1%+ cypermethrin 5.50%EC at the higher application rate of 1000 g/ml per hectare showed only 50.22% reduction of the thrips which is 45.57% lesser than the thrips reduction of the present invention (95.79%).

[0094] Similarly, the results of Tables 3, 4 and 5 shown below presents that the compositions comprising chlorantraniliprole, acetamiprid and lambda-cyhalothrin formulated into DC resulted in greater than 90% reduction of jassids and pink bollworm and 100% reduction of spodoptera litura in comparison to the untreated check. Also, the percentage reduction of jassids, pink bollworm and spodoptera litura by the present composition is higher than the individual compounds as well as conventional combinations.

Table 3: Field test results of the emamectin benzoate, acetamiprid, lambda-cyhalothrin dispersible concentrate (DC) applied against jassids in cotton at the Dehgam, Gujarat location in the Kharif season 2021.

Types Treatment Dosage Mean no. of jassids/ leaf
(DAA) %
Reduction
over UTC
(16 DAA)
g a.i./ha Formulation (g/ml/ha) Before 16 DAA
Example 2
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(recommended dosage)
11 + 25 + 20 500 3.7 1.5 90.90
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(5% reduced recommended dosage) 10.45+ 23.75 + 19 475 5 2.8 83.03
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(10% reduced recommended dosage)

9.9 + 22.5 + 18 450 5.3 3.5 78.78
Individual ingredients
Emamectin benzoate 5%SG 11 220 3.4 17 0
Lambda-cyhalothrin 5%EC 25 500 7.5 9.3 43.46
Acetamiprid 20%SP

20 100 6.4 7.4 55.15
Conventional Combinations Diafenthiuron 40.1% + Acetamiprid 3.9%WP 250.63 + 24.38 625 5.1 6.9 58.18
Chlorantraniliprole 9.3%+ Lambda cyhalothrin 4.6% ZC 23.25 + 11.5 250 5.7 7.5 54.54
Acetamiprid 1.1%+ Cypermethrin 5.50% EC 11 + 55 1000 7.1 8.3 49.69
Untreated check - - 6.5 16.5 0

DAA- Days after application

Table 4: Field test results of the emamectin benzoate, acetamiprid, lambda-cyhalothrin dispersible concentrate (DC) applied against pink bollworm in cotton at the Dehgam, Gujarat location in the Kharif season 2021.
Types Treatment Dosage Mean no.of damaged bolls/50 boll/10 plants %
Reduction
over UTC
(9 DAA)
g a.i./ha Formulation (g/ml/ha) 9 DAA
Example 2
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(recommended dosage)
11 + 25 + 20 500 1.0 90.82
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(5% reduced recommended dosage) 10.45+ 23.75 + 19 475 1.5 86.23
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(10% reduced recommended dosage)

9.9 + 22.5 + 18 450 2.0 81.65
Individual ingredients
Emamectin benzoate 5%SG 11 220 10.6 2.75
Lambda-cyhalothrin 5%EC 25 500 6.6 39.44
Acetamiprid 20%SP

20 100 9.9 9.17
Conventional Combinations Diafenthiuron 40.1% + Acetamiprid 3.9%WP 250.63 + 24.38 625 8.3 23.85
Chlorantraniliprole 9.3%+ Lambda cyhalothrin 4.6% ZC 18.6 + 9.2 200 3.3 69.72
Acetamiprid 1.1%+ Cypermethrin 5.50% EC 11 + 55 1000 7.4 32.11
Untreated check - - 10.9 0

DAA- Days after application

Table 5: Field test results of the emamectin benzoate, acetamiprid, lambda-cyhalothrin dispersible concentrate (DC) applied against spodoptera litura in cotton at Guntur, Andra Pradesh location in the Kharif season 2021.
Types Treatment Dosage Mean no. of spodoptera larvae/ leaf %
Reduction
over UTC
(15 DAA
g a.i./ha Formulation (g/ml/ha) Before 15 DAA
Example 2
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC
(recommended dosage) 11 + 25 + 20 500 1.20 0 100
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(5% reduced recommended dosage) 10.45+ 23.75 + 19 475 1.27 0.30 92.62
Emamectin benzoate 2.2% + Acetamiprid 4%+ Lambda Cyhalothrin 5% DC

(10% reduced recommended dosage)

9.9 + 22.5 + 18 450 1.27 0.50 87.71
Individual ingredients
Emamectin benzoate 5%SG 11 220 1.33 1.00 75.41
Lambda-cyhalothrin 5%EC 25 500 1.40 1.25 69.28
Acetamiprid 20%SP

20 100 1.13 4.47 0
Conventional Combinations Chlorantraniliprole 9.3%+ Lambda cyhalothrin 4.6% ZC 18.6 + 9.2 200 1.40 1.00 75.42
Acetamiprid 1.1%+ Cypermethrin 5.50% EC 11 + 55 1000 1.07 2.13 47.54
Chlorantraniliprole 18.5%SC 25 125 1.00 1.00 75.41
Untreated check - - 1.40 4.07 0

DAA- Days after application
[0095] Accordingly, from the test results shown above, it is evident that there is an unexpected and surprising result i.e., synergistic effect of the combination of emamectin benzoate, acetamiprid, lambda-cyhalothrin in the control of thrips, jassids, pink bollworm and spodoptera litura in the cotton fields. As can be seen from Tables 2 to 5, the combined administration of emamectin benzoate, acetamiprid, lambda-cyhalothrin resulted in significant reduction in insect population as compared to single administration of the individual insecticides. It is also evident that the combination in accordance with the present invention exhibits a superior insecticidal effect as compared to other known registered insecticide combination products available in the market.
[0096] The foregoing examples are merely illustrative and are not to be taken as limitations upon the scope of the invention. Various changes and modifications to the disclosed examples will be apparent to those skilled in the art. Such changes and modifications may be made without departing from the scope of the invention.

,CLAIMS:We Claim:
1. An insecticide composition comprising emamectin benzoate, acetamiprid, lambda-cyhalothrin and inactive excipients.
2. The insecticide composition as claimed in claim 1, wherein the inactive excipients consist of a dispersing agent, an emulsifier, a pH modifier, a co-solvent and a solvent.
3. The insecticide composition as claimed in claim 2, wherein the dispersing agent is selected from the group comprising of lignosulphonates, phenyl naphthalene sulphonates, polyaromatic sulfonates, sodium alkyl aryl sulfonates, maleic anhydride copolymers, phosphate esters, condensation products of aryl/alkyl sulphonic acids and formaldehyde, addition products of ethylene oxide and fatty acid esters, polycarboxylates alkali earth metal salt of alkylbenzene sulfonate, calcium dodecylbenzene sulfonate, salts of sulfonated naphthalene, polystyrenated acrylated co- polymer, salts of polyacrylic acids, salts of phenol sulfonic acids, and mixtures thereof.
4. The insecticide composition as claimed in claim 2, wherein the emulsifier is selected from the group comprising of polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols, phosphoric esters of polyethoxylated phenols or alcohols or polycarboxylate, alkoxylated alcohols, ethoxylated alcohols, ethoxylated propoxylated alcohols, alkylphenolethoxylates, alkoxylated tristyrylphenols, tristyryphenol ethoxylate, alkoxylated tributylphenols, alkylaminethoxylates, ethoxylated propoxylated polyaryl phenol, ethoxylated poly adducts of ethylene oxide and propylene oxide, ethoxylated fatty acids, sorbitan esters and their ethoxylates, sorbitol esters, propylene glycol esters of fatty acids and polyglycerol esters, ethoxylated ricinoleic acid triglycerides or castor oil ethoxylate, and mixtures thereof.
5. The insecticide composition as claimed in claim 2, wherein the pH modifier is selected from the group comprising of sodium silicate, potassium silicate, magnesium silicate, manganese silicate, sodium pyrophosphate, sodium acetate, sodium oxalate, sodium carbonate, sodium bicarbonate, sodium bentonite, sodium acetate, attapulgite, diatomaceous earth, sodium zeolite, trisodium phosphate, trisodium citrate, magnesium carbonate, magnesium sulphate, monoethanol amine, triethanol amine, triethylamine, dibasic esters selected from dimethyl succinate, dimethyl glutarate, dimethyl adipate, ortho phosphoric acid, oxalic acid, citric acid, hydrochloric acid, and mixtures thereof.
6. The insecticide composition as claimed in claim 2,wherein the co-solvent is selected from the group comprising of solvent naphtha (heavy, medium, light), turpentine oil, xylene, toluene, 1,2,4-trimethylbenzene(pseudocumene) and mixtures thereof.
7. The insecticide composition as claimed in claim 2, wherein the solvent is selected from the group comprising of deionized (DI) water, N-alkyl pyrrolidone, N-methyl-2-pyrrolidone, dimethylformamide (DMF), dimethylsulfoxide (DMSO), and mixtures thereof.
8. The insecticide composition as claimed in claim 1 or 2, wherein the composition comprises emamectin benzoate in an amount of from 0.1% to 30 % w/w, acetamiprid in an amount of from 0.1% to 40% w/w and lambda-cyhalothrin in an amount of from 0.1% to 25% w/w, dispersing agent in an amount of from 0.01% to 9% w/w, an emulsifier in an amount of from 0.3% to 28% w/w, a pH modifier in an amount of from 0.01% to 5% w/w, a co-solvent in an amount of from 0.01 % to 35% w/w and a solvent in an amount of from 1.0% to 95% w/w.
9. The insecticide composition as claimed in claim 1, wherein the composition is formulated as a water-dispersible granule (WDG), a water-soluble granule (SG), a wettable powder (WP), a water-dispersible powder (WDP), a water-soluble powder (SP), a granule (GR), an encapsulated granule (CG), a fine granule (FG), a macrogranule (GG), a microgranule (MG), a suspension concentrate (SC), a water-soluble concentrate (SL), an emulsifiable concentrate (EC), an emulsion (EW), a micro-emulsion (ME), a flowable suspension (FS), a suspoemulsion (SE), ZC formulation (ZC), soil applied granules (SAG), dustable powder (DP), a gel, a water-dispersible tablet (WT), an oil-dispersion (OD), a dispersible concentrate (DC) or a microencapsulated suspension (CS).
10. The insecticide composition as claimed in claim 9, wherein the composition is in the form of a dispersible concentrate (DC).
11. The insecticide composition as claimed in claim 10, wherein the dispersible concentrate (DC) comprises:
a) 0.1 – 30.0% w/w emamectin benzoate;
b) 0.1% to 40.0% w/w acetamiprid;
c) 0.1% to 25.0% w/w lambda-cyhalothrin;
d) 0.01 - 9.0% w/w dispersing agent;
e) 0.3 – 28.0% w/w emulsifier;
f) 0.01 – 5.0% w/w pH modifier;
g) 0.01– 35.0% w/w co-solvent; and
h) 1.0% to 95.0% w/w solvent.

12. The insecticide composition as claimed in claim 11, wherein the dispersible concentrate (DC) comprises:
a) 0.1 – 30.0% w/w emamectin benzoate;
b) 0.1% to 40.0% w/w acetamiprid;
c) 0.1% to 25.0%w/w lambda-cyhalothrin;
d) 0.01 - 9.0% w/w dispersing agent is selected from the group comprising of calcium dodecylbenzene sulfonate, polystyrenated acrylated co- polymer, salts of polyacrylic acids, and mixtures thereof;
e) 0.3 – 28.0% w/w emulsifier is selected from the group comprising of,ethoxylated propoxylated alcohols, tristyryphenol ethoxylate, ethoxylated propoxylated polyaryl phenol, ethoxylated poly adducts of ethylene oxide and propylene oxide, propylene glycol esters of fatty acids and polyglycerol esters, and mixtures thereof;
f) 0.01 – 5.0% w/w pH modifier is selected from the group comprising of sodium acetate, trisodium phosphate, trisodium citrate, ortho phosphoric acid, oxalic acid, citric acid, and mixtures thereof;
g) 0.01 – 35.0% w/w co-solvent is selected from the group comprising of solvent naphtha (heavy, medium, light), 1,2,4-trimethylbenzene(pseudocumene), and mixtures thereof; and
h) 1.0% to 95.0% w/w solvent is selected from the group comprising of deionized (DI) water, N-alkyl pyrrolidone, N-methyl-2-pyrrolidone, dimethylformamide (DMF), dimethylsulfoxide (DMSO), and mixtures thereof.

13. The insecticidal composition as claimed in claim 11 comprising:
a) emamectin benzoate in an amount of 2.2% w/w;
b) acetamiprid in an amount of 4.0% w/w;
c) lambda-cyhalothrin in an amount of 5.0% w/w;
d) calcium dodecylbenzene sulfonate in an amount of 3.0% w/w,
e) ethoxylated propoxylated polyarylphenol in an amount of 12% w/w,
f) ortho phosphoric acid in an amount of 0.8% w/w,
g) solvent naphtha in an amount of 8.0% w/w; and
h) N-methyl-2-pyrrolidone in an amount of 65% w/w.

14. A process for preparing the dispersible concentrate (DC) as claimed in claim 10, the process comprising:
a) mixing the inactive excipients to obtain a solution;
b) adding emamectin benzoate, acetamiprid and lambda-cyhalothrin to the solution and continuing to mix to obtain a transparent homogeneous solution; and
c) filtering the transparent homogeneous solution to obtain the dispersible concentrate (DC).

15. The process for preparing the dispersible concentrate (DC) as claimed in claim 14, wherein the inactive excipients consist of a dispersing agent, an emulsifier, a pH modifier, a co-solvent and a solvent.