“Kinase Inhibitors”

Abstract: The present invention provides kinase inhibitors of Formula (I). Wherein R1, R2, X and Z are as described herein, or a pharmaceutically acceptable salt thereof.

Patent Information

Application #

Filing Date

07 May 2008

Publication Number

12/2009

Publication Type

INA

Invention Field

PHARMACEUTICALS

Status

Email

Parent Application

Applicants

ELI LILLY AND COMPANY

Lilly Corporate Center Indianapolis IN 46285 US

Inventors

1. BASTIAN, Jolie, Anne

5143 Oak Farm Drive Indianapolis Indiana 46237 US;

2. BLAS DE BLAS, Jesus, Andres

Lilly S.A. Avenida De la Industria 30 E-28100 Alcobendas Madrid ES;

3. DE DIOS, Alfonso

13330 Grouse Pointe Trail Carmel Indiana 46033 US;

4. HUDZIAK, Kevin, John

5944 Magnificent Lane Indianapolis Indiana 46234 US;

5. LI, Tiechao

12853 Turnham Drive Fishers Indiana 46038 US;

6. LOPEZ DE URALDE-GARMENDIA, Beatriz

Lilly S.A. Avenida De la Industria 30 E-28100 Alcobendas Madrid ES;

7. MADER, Mary, Margaret

11188 Avery Row Fishers Indiana 46038 US;

8. MYERS, Michael, Ray

11227 Windermere Boulevard Fishers Indiana 46074 US;

9. POBANZ, Mark, Andrew

3845 Earhart Drive Westfield Indiana 46074 US;

10. SHIH, Chuan

12532 Pebblepointe Pass Carmel Indiana 46033 US;

11. ZHONG, Boyu

11261 Williams Court Carmel Indiana 46033 US;

Specification

The p38 kinase is a mitogen-activated protein (MAP) kinase that belongs to the serine/threonine kinase superfamily. This kinase is activated by extracellular stresses such as heat, UV light, and osmotic stress, as well as by inflammatory stimuli such as lipopolysaccharide...........

Documents

Application Documents

#	Name	Date
1	3894-delnp-2008-Form-13-(14-05-2008).pdf	2008-05-14
1	3894-DELNP-2008_EXAMREPORT.pdf	2016-06-30
2	3894-DELNP-2008-Form-26-(19-05-2010).pdf	2010-05-19
2	Form-1.pdf	2011-08-21
3	3894-DELNP-2008-Correspondence-Others-(19-05-2010).pdf	2010-05-19
3	Form-3.pdf	2011-08-21
4	Form-5.pdf	2011-08-21
5	3894-DELNP-2008-Correspondence-Others-(19-05-2010).pdf	2010-05-19
5	Form-3.pdf	2011-08-21
6	3894-DELNP-2008-Form-26-(19-05-2010).pdf	2010-05-19
6	Form-1.pdf	2011-08-21
7	3894-delnp-2008-Form-13-(14-05-2008).pdf	2008-05-14
7	3894-DELNP-2008_EXAMREPORT.pdf	2016-06-30