Abstract: The present disclosure provides a composition for inhibiting growth of skin infection causing pathogenic microorganisms. In particular, the present disclosure provides a composition comprising synergistic concentrations of (a) lauramine oxide and (b) at least one essential oil selected from the group consisting of Trachyspermum copticum oil, Melaleuca ericifolia oil and linalool (Ex Basil). Also provided are formulations comprising said composition, methods of preparation and use of same.
[cannot able to paste description]
I/We claim:
1. A topical anti-microbial composition comprising synergistic concentrations
of:
i. lauramine oxide, and
ii. at least one essential oil selected from the group consisting of Trachyspermum copticum oil, Melaleuca ericifolia oil and linalool (Ex Basil).
2. The composition as claimed in claim 1, wherein the synergistic concentration
of lauramine oxide is in the range of 0.61 - 1.22 ppm.
3. The composition as claimed in any of the claims 1-2, wherein the synergistic
concentration of at least one essential oil selected from:
i. Trachyspermum copticum oil is in the range of 195.31 - 781.25 ppm; ii. Melaleuca ericifolia oil is in the range of 1562.5 - 6250 ppm; and iii. linalool (Ex Basil) is in the range of 781.25 - 1562.5 ppm.
4. The composition as claimed in any of the claims 1-3, wherein the composition
comprises:
lauramine oxide in the range of 0.61 - 1.22 ppm; and Trachyspermum copticum oil in the range of 195.31 - 781.25 ppm.
5. The composition as claimed in any of the claims 1-3, wherein the composition
comprises:
lauramine oxide in the range of 0.61 - 1.22 ppm; and Melaleuca ericifolia oil in the range of 1562.5 - 6250 ppm.
6. The composition as claimed in any of the claims 1-3, wherein the composition
comprises:
lauramine oxide in the range of 0.61 - 1.22 ppm; and linalool (Ex Basil) in the range of 781.25 - 1562.5 ppm.
7. The composition as claimed in any of the claims 1-3 or 4, wherein the ratio of
lauramine oxide to Trachyspermum copticum oil is in the range of 1: 150 to
1:1400.
8. The composition as claimed in any of the claims 1-3 or 5, wherein the ratio of
lauramine oxide to Melaleuca ericifolia oil is in the range of 1: 1300 to
1:11000.
9. The composition as claimed in any of the claims 1-3 or 6, wherein the ratio of
lauramine oxide to linalool is in the range of 1: 600 to 1:2600.
10. An anti-microbial formulation comprising a composition as claimed in any of
the claims 1-9.
11. The formulation as claimed in claim 10, further comprising one or more
cosmetically acceptable excipients selected from the group consisting of fatty
acids, alkalis, viscosity modifiers, polymers, humectants, colors, solubilizer,
opacifier, binder, fragrances, surfactants, chelating agents, emulsifying agent,
neutralizing agents, preservative, emollients and diluents.
12. The formulation as claimed in claim 11, wherein the formulation comprises of
i. weight concentration of at least one fatty acid is in the range of 10 to
70%; ii. weight concentration of at least one surfactant is in the range of 0.1 to
20%; iii. weight concentration of at least one polymer is in the range of 0.005-
2%; iv. weight concentration of at least one chelating agent is in the range of
0.001-5%; v. weight concentration of at least one emollient is in the range of 0.001-
10%; vi. weight concentration of at least one humectant is in the range of 0.01-
5%;
vii. weight concentration of at least one emulsifying agent is in the range
of 0.01-5%; viii. weight concentration of at least one fragrance is in the range of 0.01-3%; and
ix. weight concentration of at least one cosmetically acceptable additive is in the range of 0.001-5%. 13. The formulation as claimed in any of the claims 10-12, wherein
i. at least one polymer is selected from the group consisting of (a) at least one starch; (b) at least one modified starch; (c) at least one gum; (d) at least one carbomer; (e) at least one silicone based polymer; (f) at least one acrylate; (g) at least one cellulose based polymer; and (h) combinations thereof;
ii. at least one chelating agent is selected from the group consisting of dimercapto-succinic acid (DMSA), dimercapto-propane sulfonate (DMPS), alpha lipoic acid (ALA), calcium disodium versante (CaNa2-EDTA), disodium EDTA, dimercaprol (BAL), etidronic acid, ethyleneglycoltetraacetic acid, ethylenediaminedisuccinic acid, and combinations thereof;
iii. at least one emollient is selected from the group consisting of lanolin, octyldodecanol, hexyl decanol, oleyl alcohol, decyloleate, isopropyl stearate, isopropyl palmitate, isopropyl myristate, hexyl laureate, dioctyl cyclohexane, PPG-15 stearyl ether, isohexadecane, stearic acid, cetyl alcohol, mineral oil, at least one ester, at least one alcohol, at least one essential oil and extracts thereof, at least one silicone oil, linear polydimethylsiloxanes, cyclic polydimethylsiloxanes, volatile silicones, and combinations thereof;
iv. at least one humectant selected from the group consisting of at least one silicone, at least one silicone oil, at least one silicone polymer, at least one cyclized derivative of silicone, at least one polyol, at least
one acrylate polymer, at least one biopolymer, and combinations thereof; v. at least one emulsifying agent selected from the group consisting of oxyalkylenated fatty acid esters of polyols, PEG-100 stearate & glyceryl stearate, oxyalkylenated fatty acid esters of sorbitan, oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty alcohol ethers, alkoxylated or non-alkoxylated sugar esters, sorbitan esters, esters of diacids, esters of fatty alcohols, acrylates, PEG based emulsifiers, polyglyceryl based emulsifiers, silicones, dimethicones, mixture of glycerylmonostearate and of polyethylene glycol stearate and combinations thereof;
vi. at least one fragrance selected from the group consisting of blend of essential oils, blend of synthetic aroma compounds, and combinations thereof; and
vii. at least one cosmetically acceptable additive is selected from the group consisting of colorants, antioxidants, free radical scavengers, vitamins, anti-aging agents, thickeners, and combinations thereof.
14. An anti-microbial personal cleansing formulation, comprising:
i. at least one C8 to C18 fatty acid in a range of 10 to 25% by weight;
ii. at least one alkali in a range of 0.001 to 5% by weight;
iii. at least one solubilizer in a range of 5 to 40% by weight;
iv. optionally, at least one chelating agent in a range of 0.001 to 5 % by weight;
v. lauramine oxide in a range of 0.61 - 1.22 ppm;
vi. Trachyspermum copticum oil in a range of 195.31 - 781.25 ppm or Melaleuca ericifolia oil in a range of 1562.5 - 6250 ppm or linalool (Ex Basil) in a range of 781.25 - 1562.5 ppm; and
vii. water to make up 100% weight.
15. An anti-microbial personal cleansing formulation, comprising:
46
i. at least one surfactant in a range of 2 to 20% by weight;
ii. at least one polymer in a range of 0.1 to 15% by weight;
iii. at least one solubilizer in a range of 0 to 10% by weight;
iv. optionally, at least one chelating agent in a range of 0.001-5%) by weight;
v. lauramine oxide in a range of 0.61 - 1.22 ppm;
vi. Trachyspermum copticum oil in a range of 195.31 - 781.25 ppm or Melaleuca ericifolia oil in a range of 1562.5 - 6250 ppm or linalool (Ex Basil) in a range of 781.25 - 1562.5 ppm; and
vii. water to make up 100%> weight.
16. An anti-microbial soap bar formulation, comprising:
i. at least one sodium salt of fatty acid in a range of 30-95%> by weight; ii. at least one humectant and emollient in a range of 0.5 to 10%> by
weight; iii. at least one binder in a range of 0.5 to 10%> by weight; iv. optionally, at least one opacifier in a range of 0.001 to 3% by weight; v. optionally, at least one chelating agent in a range of 0.001-5%) by
weight; vi. lauramine oxide in a range of 0.61 - 1.22 ppm;
vii. Trachyspermum copticum oil in a range of 195.31 - 781.25 ppm or Melaleuca ericifolia oil in a range of 1562.5 - 6250 ppm or linalool (Ex Basil) in a range of 781.25 - 1562.5 ppm; and viii. water to make up 100%> weight.
17. A topical anti-microbial formulation, comprising:
i. at least one polymer in a range of 0.005-5%) by weight;
ii. at least one emulsifying agent in a range of 0.01-5%) by weight; iii. at least one humectant in a range of 0.01-10%o by weight; iv. at least one preservative in a range of 0.001-1%> by weight;
v. at least one neutralizing agent in a range of 0-0.75% by weight;
vi. optionally, at least one chelating agent in a range of 0.001-5% by
weight; vii. lauramine oxide in a range of 0.61 - 1.22 ppm; viii. Trachyspermum copticum oil in a range of 195.31 - 781.25 ppm or
Melaleuca ericifolia oil in a range of 1562.5 - 6250 ppm or linalool
(Ex Basil) in a range of 781.25 - 1562.5 ppm; and ix. water to make up 100% weight.
| # | Name | Date |
|---|---|---|
| 1 | Form 5 [29-03-2017(online)].pdf | 2017-03-29 |
| 2 | Form 3 [29-03-2017(online)].pdf | 2017-03-29 |
| 3 | Drawing [29-03-2017(online)].pdf | 2017-03-29 |
| 4 | Description(Complete) [29-03-2017(online)].pdf_136.pdf | 2017-03-29 |
| 5 | Description(Complete) [29-03-2017(online)].pdf | 2017-03-29 |
| 6 | PROOF OF RIGHT [30-05-2017(online)].pdf | 2017-05-30 |
| 7 | Form 26 [30-05-2017(online)].pdf | 2017-05-30 |
| 8 | Correspondence by Agent_Proof of Right_02-06-2017.pdf | 2017-06-02 |