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Material For Blood Purification

Abstract: The purpose of the present invention is to provide a material for blood purification having the ability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification that includes a water-insoluble material in which a ligand having amide groups and amino groups is bonded to a substrate the amide group content being 3.0-7.0 mmol per gram dry weight of the water-insoluble material and the amino group content being 1.0-7.0 mmol per gram dry weight of the water-insoluble material.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
06 March 2019
Publication Number
11/2019
Publication Type
INA
Invention Field
BIO-MEDICAL ENGINEERING
Status
Email
patent@depenning.com
Parent Application
Patent Number
Legal Status
Grant Date
2024-02-01
Renewal Date

Applicants

TORAY INDUSTRIES, INC.
1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666

Inventors

1. KANDA, Shungo
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558
2. TAKAHASHI, Hiroshi
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558
3. TOMITA, Naotoshi
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558

Specification

1. A material for blood purification, the material comprising a water-insoluble
material in which a ligand having an amide group(s) and an amino group(s) is bound
to a substrate,
wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and
wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.
2. The material for blood purification, according to claim 1, wherein the ligand
having the structure represented by Formula (I) below is bound to the substrate:
vwwwwww
I °
H H2
(I)
(wherein X is an amino group; and the wavy line represents a position at which the ligand is bound to the substrate).
3. The material for blood purification, according to claim 1 or 2, wherein the
ligand has a phenyl group, and the ligand having the structure represented by
Formula (II) below is bound to the substrate:
wwwwww
N C A
H H2
(I I) (wherein X is an amino group; A is a linker; B is a hydrogen atom or halogen atom;
and the wavy line represents a position at which the ligand is bound to the substrate);
and
wherein the content of the phenyl group is more than 0 mmol and not more than
7.0 mmol per 1 g dry weight of the water-insoluble material.
4. The material for blood purification, according to any one of claims 1 to 3,

wherein the substrate is a polystyrene or polysulfone, or a derivative thereof.
5. The material for blood purification, according to any one of claims 1 to 4, wherein the material is in the form of fibers or particles.
6. The material for blood purification, according to any one of claims 1 to 5, wherein the material is in the form of a knitted fabric having an opening ratio of 0.1 to 30.0%.
7. The material for blood purification, according to any one of claims 1 to 6, wherein the material is for removing a cytokine and an activated leukocyte-activated platelet complex.
8. An apparatus for blood purification, the apparatus comprising the material for blood purification, according to any one of claims 1 to 7.

Documents

Application Documents

# Name Date
1 201947008664-IntimationOfGrant01-02-2024.pdf 2024-02-01
1 201947008664.pdf 2019-03-06
2 201947008664-PatentCertificate01-02-2024.pdf 2024-02-01
2 201947008664-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [06-03-2019(online)].pdf 2019-03-06
3 201947008664-STATEMENT OF UNDERTAKING (FORM 3) [06-03-2019(online)].pdf 2019-03-06
3 201947008664-FORM 3 [08-04-2022(online)].pdf 2022-04-08
4 201947008664-PRIORITY DOCUMENTS [06-03-2019(online)].pdf 2019-03-06
4 201947008664-CLAIMS [01-04-2022(online)].pdf 2022-04-01
5 201947008664-POWER OF AUTHORITY [06-03-2019(online)].pdf 2019-03-06
5 201947008664-FER_SER_REPLY [01-04-2022(online)].pdf 2022-04-01
6 201947008664-FORM 3 [01-04-2022(online)].pdf 2022-04-01
6 201947008664-FORM 1 [06-03-2019(online)].pdf 2019-03-06
7 201947008664-Information under section 8(2) [01-04-2022(online)].pdf 2022-04-01
7 201947008664-DRAWINGS [06-03-2019(online)].pdf 2019-03-06
8 201947008664-OTHERS [01-04-2022(online)].pdf 2022-04-01
8 201947008664-DECLARATION OF INVENTORSHIP (FORM 5) [06-03-2019(online)].pdf 2019-03-06
9 201947008664-COMPLETE SPECIFICATION [06-03-2019(online)].pdf 2019-03-06
9 201947008664-FORM-26 [01-03-2022(online)].pdf 2022-03-01
10 201947008664-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [06-03-2019(online)].pdf 2019-03-06
10 201947008664-FER.pdf 2021-11-09
11 201947008664-FORM 3 [31-12-2020(online)].pdf 2020-12-31
11 201947008664-Proof of Right (MANDATORY) [12-03-2019(online)].pdf 2019-03-12
12 201947008664-FORM 18 [26-06-2020(online)].pdf 2020-06-26
12 Correspondence by Agent_Form 1_14-03-2019.pdf 2019-03-14
13 201947008664-FORM 3 [04-06-2019(online)].pdf 2019-06-04
13 201947008664-FORM 3 [22-06-2020(online)].pdf 2020-06-22
14 201947008664-FORM 3 [04-06-2019(online)].pdf 2019-06-04
14 201947008664-FORM 3 [22-06-2020(online)].pdf 2020-06-22
15 201947008664-FORM 18 [26-06-2020(online)].pdf 2020-06-26
15 Correspondence by Agent_Form 1_14-03-2019.pdf 2019-03-14
16 201947008664-FORM 3 [31-12-2020(online)].pdf 2020-12-31
16 201947008664-Proof of Right (MANDATORY) [12-03-2019(online)].pdf 2019-03-12
17 201947008664-FER.pdf 2021-11-09
17 201947008664-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [06-03-2019(online)].pdf 2019-03-06
18 201947008664-COMPLETE SPECIFICATION [06-03-2019(online)].pdf 2019-03-06
18 201947008664-FORM-26 [01-03-2022(online)].pdf 2022-03-01
19 201947008664-DECLARATION OF INVENTORSHIP (FORM 5) [06-03-2019(online)].pdf 2019-03-06
19 201947008664-OTHERS [01-04-2022(online)].pdf 2022-04-01
20 201947008664-DRAWINGS [06-03-2019(online)].pdf 2019-03-06
20 201947008664-Information under section 8(2) [01-04-2022(online)].pdf 2022-04-01
21 201947008664-FORM 1 [06-03-2019(online)].pdf 2019-03-06
21 201947008664-FORM 3 [01-04-2022(online)].pdf 2022-04-01
22 201947008664-FER_SER_REPLY [01-04-2022(online)].pdf 2022-04-01
22 201947008664-POWER OF AUTHORITY [06-03-2019(online)].pdf 2019-03-06
23 201947008664-CLAIMS [01-04-2022(online)].pdf 2022-04-01
23 201947008664-PRIORITY DOCUMENTS [06-03-2019(online)].pdf 2019-03-06
24 201947008664-FORM 3 [08-04-2022(online)].pdf 2022-04-08
24 201947008664-STATEMENT OF UNDERTAKING (FORM 3) [06-03-2019(online)].pdf 2019-03-06
25 201947008664-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [06-03-2019(online)].pdf 2019-03-06
25 201947008664-PatentCertificate01-02-2024.pdf 2024-02-01
26 201947008664.pdf 2019-03-06
26 201947008664-IntimationOfGrant01-02-2024.pdf 2024-02-01

Search Strategy

1 201947008664E_02-11-2021.pdf

ERegister / Renewals

3rd: 09 Mar 2024

From 08/09/2019 - To 08/09/2020

4th: 09 Mar 2024

From 08/09/2020 - To 08/09/2021

5th: 09 Mar 2024

From 08/09/2021 - To 08/09/2022

6th: 09 Mar 2024

From 08/09/2022 - To 08/09/2023

7th: 09 Mar 2024

From 08/09/2023 - To 08/09/2024

8th: 02 Aug 2024

From 08/09/2024 - To 08/09/2025

9th: 31 Jul 2025

From 08/09/2025 - To 08/09/2026