Abstract: The purpose of the present invention is to provide a material for blood purification having the ability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification that includes a water-insoluble material in which a ligand having amide groups and amino groups is bonded to a substrate the amide group content being 3.0-7.0 mmol per gram dry weight of the water-insoluble material and the amino group content being 1.0-7.0 mmol per gram dry weight of the water-insoluble material.
1. A material for blood purification, the material comprising a water-insoluble
material in which a ligand having an amide group(s) and an amino group(s) is bound
to a substrate,
wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and
wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.
2. The material for blood purification, according to claim 1, wherein the ligand
having the structure represented by Formula (I) below is bound to the substrate:
vwwwwww
I °
H H2
(I)
(wherein X is an amino group; and the wavy line represents a position at which the ligand is bound to the substrate).
3. The material for blood purification, according to claim 1 or 2, wherein the
ligand has a phenyl group, and the ligand having the structure represented by
Formula (II) below is bound to the substrate:
wwwwww
N C A
H H2
(I I) (wherein X is an amino group; A is a linker; B is a hydrogen atom or halogen atom;
and the wavy line represents a position at which the ligand is bound to the substrate);
and
wherein the content of the phenyl group is more than 0 mmol and not more than
7.0 mmol per 1 g dry weight of the water-insoluble material.
4. The material for blood purification, according to any one of claims 1 to 3,
wherein the substrate is a polystyrene or polysulfone, or a derivative thereof.
5. The material for blood purification, according to any one of claims 1 to 4, wherein the material is in the form of fibers or particles.
6. The material for blood purification, according to any one of claims 1 to 5, wherein the material is in the form of a knitted fabric having an opening ratio of 0.1 to 30.0%.
7. The material for blood purification, according to any one of claims 1 to 6, wherein the material is for removing a cytokine and an activated leukocyte-activated platelet complex.
8. An apparatus for blood purification, the apparatus comprising the material for blood purification, according to any one of claims 1 to 7.
| # | Name | Date |
|---|---|---|
| 1 | 201947008664-IntimationOfGrant01-02-2024.pdf | 2024-02-01 |
| 1 | 201947008664.pdf | 2019-03-06 |
| 2 | 201947008664-PatentCertificate01-02-2024.pdf | 2024-02-01 |
| 2 | 201947008664-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [06-03-2019(online)].pdf | 2019-03-06 |
| 3 | 201947008664-STATEMENT OF UNDERTAKING (FORM 3) [06-03-2019(online)].pdf | 2019-03-06 |
| 3 | 201947008664-FORM 3 [08-04-2022(online)].pdf | 2022-04-08 |
| 4 | 201947008664-PRIORITY DOCUMENTS [06-03-2019(online)].pdf | 2019-03-06 |
| 4 | 201947008664-CLAIMS [01-04-2022(online)].pdf | 2022-04-01 |
| 5 | 201947008664-POWER OF AUTHORITY [06-03-2019(online)].pdf | 2019-03-06 |
| 5 | 201947008664-FER_SER_REPLY [01-04-2022(online)].pdf | 2022-04-01 |
| 6 | 201947008664-FORM 3 [01-04-2022(online)].pdf | 2022-04-01 |
| 6 | 201947008664-FORM 1 [06-03-2019(online)].pdf | 2019-03-06 |
| 7 | 201947008664-Information under section 8(2) [01-04-2022(online)].pdf | 2022-04-01 |
| 7 | 201947008664-DRAWINGS [06-03-2019(online)].pdf | 2019-03-06 |
| 8 | 201947008664-OTHERS [01-04-2022(online)].pdf | 2022-04-01 |
| 8 | 201947008664-DECLARATION OF INVENTORSHIP (FORM 5) [06-03-2019(online)].pdf | 2019-03-06 |
| 9 | 201947008664-COMPLETE SPECIFICATION [06-03-2019(online)].pdf | 2019-03-06 |
| 9 | 201947008664-FORM-26 [01-03-2022(online)].pdf | 2022-03-01 |
| 10 | 201947008664-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [06-03-2019(online)].pdf | 2019-03-06 |
| 10 | 201947008664-FER.pdf | 2021-11-09 |
| 11 | 201947008664-FORM 3 [31-12-2020(online)].pdf | 2020-12-31 |
| 11 | 201947008664-Proof of Right (MANDATORY) [12-03-2019(online)].pdf | 2019-03-12 |
| 12 | 201947008664-FORM 18 [26-06-2020(online)].pdf | 2020-06-26 |
| 12 | Correspondence by Agent_Form 1_14-03-2019.pdf | 2019-03-14 |
| 13 | 201947008664-FORM 3 [04-06-2019(online)].pdf | 2019-06-04 |
| 13 | 201947008664-FORM 3 [22-06-2020(online)].pdf | 2020-06-22 |
| 14 | 201947008664-FORM 3 [04-06-2019(online)].pdf | 2019-06-04 |
| 14 | 201947008664-FORM 3 [22-06-2020(online)].pdf | 2020-06-22 |
| 15 | 201947008664-FORM 18 [26-06-2020(online)].pdf | 2020-06-26 |
| 15 | Correspondence by Agent_Form 1_14-03-2019.pdf | 2019-03-14 |
| 16 | 201947008664-FORM 3 [31-12-2020(online)].pdf | 2020-12-31 |
| 16 | 201947008664-Proof of Right (MANDATORY) [12-03-2019(online)].pdf | 2019-03-12 |
| 17 | 201947008664-FER.pdf | 2021-11-09 |
| 17 | 201947008664-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [06-03-2019(online)].pdf | 2019-03-06 |
| 18 | 201947008664-COMPLETE SPECIFICATION [06-03-2019(online)].pdf | 2019-03-06 |
| 18 | 201947008664-FORM-26 [01-03-2022(online)].pdf | 2022-03-01 |
| 19 | 201947008664-DECLARATION OF INVENTORSHIP (FORM 5) [06-03-2019(online)].pdf | 2019-03-06 |
| 19 | 201947008664-OTHERS [01-04-2022(online)].pdf | 2022-04-01 |
| 20 | 201947008664-DRAWINGS [06-03-2019(online)].pdf | 2019-03-06 |
| 20 | 201947008664-Information under section 8(2) [01-04-2022(online)].pdf | 2022-04-01 |
| 21 | 201947008664-FORM 1 [06-03-2019(online)].pdf | 2019-03-06 |
| 21 | 201947008664-FORM 3 [01-04-2022(online)].pdf | 2022-04-01 |
| 22 | 201947008664-FER_SER_REPLY [01-04-2022(online)].pdf | 2022-04-01 |
| 22 | 201947008664-POWER OF AUTHORITY [06-03-2019(online)].pdf | 2019-03-06 |
| 23 | 201947008664-CLAIMS [01-04-2022(online)].pdf | 2022-04-01 |
| 23 | 201947008664-PRIORITY DOCUMENTS [06-03-2019(online)].pdf | 2019-03-06 |
| 24 | 201947008664-FORM 3 [08-04-2022(online)].pdf | 2022-04-08 |
| 24 | 201947008664-STATEMENT OF UNDERTAKING (FORM 3) [06-03-2019(online)].pdf | 2019-03-06 |
| 25 | 201947008664-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [06-03-2019(online)].pdf | 2019-03-06 |
| 25 | 201947008664-PatentCertificate01-02-2024.pdf | 2024-02-01 |
| 26 | 201947008664.pdf | 2019-03-06 |
| 26 | 201947008664-IntimationOfGrant01-02-2024.pdf | 2024-02-01 |
| 1 | 201947008664E_02-11-2021.pdf |