Abstract: The purpose of the present invention is to provide a material that can very efficiently remove the activated leukocyte-activated platelet complex. The present invention provides a material that removes the activated leukocyte-activated platelet complex, which is a water-insoluble carrier having a surface to which a compound having a charge-bearing functional group is bonded, wherein the profile length ratio of this surface is 4 to 7.
WE CLAIM:
1. A material for removing an activated leukocyte-activated platelet complex,
the material being a water-insoluble carrier to the surface of which carrier a
compound(s) having a charged functional group(s) is(are) bound,
wherein an extending length ratio of said surface is 4 to 7.
2. The material for removing, according to claim 1, wherein a center line mean roughness of said surface is 2 to 10 um.
3. The material for removing, according to claim 1 or 2, wherein the absolute value of charge amount of the functional group(s) is 0.3 to 3.0 mmol per 1 g dry weight of said water-insoluble carrier.
4. The material for removing, according to any one of claims 1 to 3, wherein said charged functional group is an amino group.
5. The material for removing, according to any one of claims 1 to 4, wherein said water-insoluble carrier is in the form of fibers, and the fiber has a fiber diameter of 1 to 100 um.
6. The material for removing, according to any one of claims 1 to 5, wherein said water-insoluble carrier comprises one or more polymers selected from the group consisting of polystyrene, polysulfone, and polyethersulfone.
7. The material for removing, according to any one of claims 1 to 6, wherein the material adsorbs and removes an activated leukocyte, IL-6, IL-8, or HMGB-1.
8. A column for blood purification, the column comprising the material for removing, according to any one of claims 1 to 7.
9. A column for blood purification for treating a respiratory disease, the column comprising the material for removing, according to any one of claims 1 to 7.
| # | Name | Date |
|---|---|---|
| 1 | 201947049826.pdf | 2019-12-04 |
| 2 | 201947049826-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [04-12-2019(online)].pdf | 2019-12-04 |
| 3 | 201947049826-STATEMENT OF UNDERTAKING (FORM 3) [04-12-2019(online)].pdf | 2019-12-04 |
| 4 | 201947049826-PROOF OF RIGHT [04-12-2019(online)].pdf | 2019-12-04 |
| 5 | 201947049826-PRIORITY DOCUMENTS [04-12-2019(online)].pdf | 2019-12-04 |
| 6 | 201947049826-FORM-26 [04-12-2019(online)].pdf | 2019-12-04 |
| 7 | 201947049826-FORM 1 [04-12-2019(online)].pdf | 2019-12-04 |
| 8 | 201947049826-DRAWINGS [04-12-2019(online)].pdf | 2019-12-04 |
| 9 | 201947049826-DECLARATION OF INVENTORSHIP (FORM 5) [04-12-2019(online)].pdf | 2019-12-04 |
| 10 | 201947049826-COMPLETE SPECIFICATION [04-12-2019(online)].pdf | 2019-12-04 |
| 11 | 201947049826-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [04-12-2019(online)].pdf | 2019-12-04 |
| 12 | abstract_201947049826.jpg | 2019-12-09 |
| 13 | Correspondence by Agent_Form1,Power of Attorney_10-12-2019.pdf | 2019-12-10 |
| 14 | 201947049826-FORM 3 [22-01-2020(online)].pdf | 2020-01-22 |
| 15 | 201947049826-FORM 3 [08-04-2021(online)].pdf | 2021-04-08 |
| 16 | 201947049826-FORM 18 [03-05-2021(online)].pdf | 2021-05-03 |
| 17 | 201947049826-FER.pdf | 2022-02-14 |
| 18 | 201947049826-OTHERS [27-07-2022(online)].pdf | 2022-07-27 |
| 19 | 201947049826-Information under section 8(2) [27-07-2022(online)].pdf | 2022-07-27 |
| 20 | 201947049826-FORM 3 [27-07-2022(online)].pdf | 2022-07-27 |
| 21 | 201947049826-FER_SER_REPLY [27-07-2022(online)].pdf | 2022-07-27 |
| 22 | 201947049826-CLAIMS [27-07-2022(online)].pdf | 2022-07-27 |
| 23 | 201947049826-Correspondence_Affidavit_10-08-2022.pdf | 2022-08-10 |
| 24 | 201947049826-PatentCertificate05-09-2022.pdf | 2022-09-05 |
| 25 | 201947049826-IntimationOfGrant05-09-2022.pdf | 2022-09-05 |
| 1 | SearchHistory(25)-convertedE_14-02-2022.pdf |