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Material For Removing Activated Leukocyte Activated Platelet Complex

Abstract: The purpose of the present invention is to provide a material that can very efficiently remove the activated leukocyte-activated platelet complex. The present invention provides a material that removes the activated leukocyte-activated platelet complex, which is a water-insoluble carrier having a surface to which a compound having a charge-bearing functional group is bonded, wherein the profile length ratio of this surface is 4 to 7.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
04 December 2019
Publication Number
50/2019
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2022-09-05
Renewal Date

Applicants

TORAY INDUSTRIES, INC.
1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666

Inventors

1. TOMITA, Naotoshi
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558
2. SHIMADA, Kaoru
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558
3. TAKAHASHI, Hiroshi
c/o Shiga Plant, Toray Industries, Inc., 1-1, Sonoyama 1-chome, Otsu-shi, Shiga 5208558

Specification

WE CLAIM:
1. A material for removing an activated leukocyte-activated platelet complex,
the material being a water-insoluble carrier to the surface of which carrier a
compound(s) having a charged functional group(s) is(are) bound,
wherein an extending length ratio of said surface is 4 to 7.
2. The material for removing, according to claim 1, wherein a center line mean roughness of said surface is 2 to 10 um.
3. The material for removing, according to claim 1 or 2, wherein the absolute value of charge amount of the functional group(s) is 0.3 to 3.0 mmol per 1 g dry weight of said water-insoluble carrier.
4. The material for removing, according to any one of claims 1 to 3, wherein said charged functional group is an amino group.
5. The material for removing, according to any one of claims 1 to 4, wherein said water-insoluble carrier is in the form of fibers, and the fiber has a fiber diameter of 1 to 100 um.
6. The material for removing, according to any one of claims 1 to 5, wherein said water-insoluble carrier comprises one or more polymers selected from the group consisting of polystyrene, polysulfone, and polyethersulfone.
7. The material for removing, according to any one of claims 1 to 6, wherein the material adsorbs and removes an activated leukocyte, IL-6, IL-8, or HMGB-1.
8. A column for blood purification, the column comprising the material for removing, according to any one of claims 1 to 7.
9. A column for blood purification for treating a respiratory disease, the column comprising the material for removing, according to any one of claims 1 to 7.

Documents

Application Documents

# Name Date
1 201947049826.pdf 2019-12-04
2 201947049826-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [04-12-2019(online)].pdf 2019-12-04
3 201947049826-STATEMENT OF UNDERTAKING (FORM 3) [04-12-2019(online)].pdf 2019-12-04
4 201947049826-PROOF OF RIGHT [04-12-2019(online)].pdf 2019-12-04
5 201947049826-PRIORITY DOCUMENTS [04-12-2019(online)].pdf 2019-12-04
6 201947049826-FORM-26 [04-12-2019(online)].pdf 2019-12-04
7 201947049826-FORM 1 [04-12-2019(online)].pdf 2019-12-04
8 201947049826-DRAWINGS [04-12-2019(online)].pdf 2019-12-04
9 201947049826-DECLARATION OF INVENTORSHIP (FORM 5) [04-12-2019(online)].pdf 2019-12-04
10 201947049826-COMPLETE SPECIFICATION [04-12-2019(online)].pdf 2019-12-04
11 201947049826-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [04-12-2019(online)].pdf 2019-12-04
12 abstract_201947049826.jpg 2019-12-09
13 Correspondence by Agent_Form1,Power of Attorney_10-12-2019.pdf 2019-12-10
14 201947049826-FORM 3 [22-01-2020(online)].pdf 2020-01-22
15 201947049826-FORM 3 [08-04-2021(online)].pdf 2021-04-08
16 201947049826-FORM 18 [03-05-2021(online)].pdf 2021-05-03
17 201947049826-FER.pdf 2022-02-14
18 201947049826-OTHERS [27-07-2022(online)].pdf 2022-07-27
19 201947049826-Information under section 8(2) [27-07-2022(online)].pdf 2022-07-27
20 201947049826-FORM 3 [27-07-2022(online)].pdf 2022-07-27
21 201947049826-FER_SER_REPLY [27-07-2022(online)].pdf 2022-07-27
22 201947049826-CLAIMS [27-07-2022(online)].pdf 2022-07-27
23 201947049826-Correspondence_Affidavit_10-08-2022.pdf 2022-08-10
24 201947049826-PatentCertificate05-09-2022.pdf 2022-09-05
25 201947049826-IntimationOfGrant05-09-2022.pdf 2022-09-05

Search Strategy

1 SearchHistory(25)-convertedE_14-02-2022.pdf

ERegister / Renewals

3rd: 15 Sep 2022

From 06/06/2020 - To 06/06/2021

4th: 15 Sep 2022

From 06/06/2021 - To 06/06/2022

5th: 15 Sep 2022

From 06/06/2022 - To 06/06/2023

6th: 11 May 2023

From 06/06/2023 - To 06/06/2024

7th: 14 May 2024

From 06/06/2024 - To 06/06/2025

8th: 03 May 2025

From 06/06/2025 - To 06/06/2026