Abstract: A method and system for removing one or more of air, oxygen, and moisture form cavities of a container for storage of pharmaceutical product is disclosed. The disclosed method and system are based on blowing, by a first fluid blowing unit, a fluid in the one or more cavities of the container to replace the oxygen and moisture from the one or more cavities of the container; dispensing a product in each of the one or more cavities of the container; creating vacuum, by a vacuum unit, in the one or more cavities of the container; blowing, by a second fluid blowing unit, the fluid in the one or more cavities of the container to replace residue oxygen and moisture from the one or more cavities of the container; and sealing, using a sealing unit, by applying one or more sealing layers on the container.
Claims:1. A method for packaging a pharmaceutical product in a container to remove one or more of air, oxygen and moisture from one or more cavities of the container, the method comprising steps of:
blowing, by a first fluid blowing unit, a fluid in the one or more cavities of the container to replace the oxygen and moisture from the one or more cavities of the container prior feeding the pharmaceutical product(s) into the cavities;
dispensing, a product in each of the one or more cavities of the container;
creating vacuum, by a vacuum unit, in the one or more cavities of the container; and
blowing, by a second fluid blowing unit, the fluid in the one or more cavities of the container to replace residue oxygen and moisture from the one or more cavities of the container prior closing the container by sealing lid to the filled bottom material.
2. The method as claimed in claim 1, wherein the method comprises a step of blowing inert dry gas prior the vacuum station.
3. The method as claimed in claim 1, wherein the method comprises a step of sealing, using a sealing unit, by applying one or more sealing layers on the container.
4. The method as claimed in claim 1, wherein the fluid is any or a combination of dry air and inert gas.
5. The method as claimed in claim 1, wherein the product is a pharmaceutical product.
6. The method as claimed in claim 1, wherein the step of blowing the fluid in the one or more cavities is performed from any or a combination of a top of the container and from sides of the container to remove the oxygen and moisture from surrounding the filled products in the one or more cavities.
7. The method as claimed in claim 1, wherein each of the first fluid blowing unit and the second blowing unit comprises one or more rows of openings to blow fluid streams in the one or more cavities, wherein the openings of each of the one or more rows of openings are arranged such that the fluid streams coming out of adjacent openings of the openings cross each other.
8. The method as claimed in anyone of the claims 1-7, wherein the container is a blister pack.
9. A system for removing one or more of an air, oxygen and a moisture from one or more cavities of a container for storage of one or more pharmaceutical products, the system comprising:
one or more fluid blowing units adapted to blow a fluid in the one or more cavities of the container to replace one or more of the air, oxygen and moisture from the one or more cavities, said each of the one or more fluid blowing units comprises one or more rows of openings to blow fluid streams in the one or more cavities, and the openings of each of the one or more rows of openings are arranged such that the fluid streams coming out of adjacent openings of the openings cross each other; and
a vacuum unit adapted to create vacuum in the one or more cavities of the container.
10. The system as claimed in claim 9, wherein the fluid is any or a combination of dry air and inert gas.
11. The system as claimed in claim 9, wherein each of the one or more fluid blowing units is made of a temperature resistant polymeric material or metal.
12. The system as claimed in claim 9, wherein the system comprises a sealing unit with flat sealing tools to provide the sealed container lacking geometric patterns.
, Description:TECHNICAL FIELD
[0001] The present invention relates to the technical field of packaging process of pharmaceutical product. In particular, it pertains to a method and a system to remove humid air and/or oxygen from one or more cavities of a medical container for storage of pharmaceutical product to improve the shelf life of the product.
BACKGROUND
[0002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Conventionally, medical containers such as blister packs are now widely used for packaging of moisture sensitive pharmaceutical products such as tablets, capsules and like. The medical container such as blister pack include multiple pockets, or cavities which may be large enough to receive the individual tablet or capsule, and a flat aluminium foil can be heat sealed to the container. The products packed into such packaging needs to be protected until the shelf live is over, which may be normally 3 to 5 years in case of pharmaceutical products.
[0004] During packaging process, air present in a production area will enter into cavities of the medical containers as well. Generally, relative humidity, which is usually 50% in the production also ingresses into the packages. During packaging of any pharmaceutical drug products such as tablets, capsules, pills etc. in a container or blister, there can be some percent of oxygen and humidity present in the air inside the container. After completion of packaging, the air with some amount of oxygen and/or humidity will remain in the container. This may lead to oxygen or humidity induced drug degradation. The oxygen induced drug degradation is a factor that can limit the shelf life, usually as indicated by the expiration date of any drug product. In the case of drugs that are highly oxygen-sensitive, such degradation may render a drug to be unmarketable or may cause a pharmaceutical company manufacturing such oxygen-sensitive drugs to be excluded from competition by causing huge losses to them. Therefore, there is a drawback due to presence of oxygen and humidity in blisters or in any other pharmaceutical product carrying containers. There might be a decrement in shelf life of the product if humid air and/or oxygen is not removed out of the blister/container before sealing or packing the blister/container.
[0005] Efforts have been made in past to provide devices or techniques for removing humid air and/or oxygen from the containers carrying oxygen-sensitive products like drugs, food items or any other products as well. Most of the conventional techniques may not be able to remove humid air and/or oxygen efficiently and completely as some residual oxygen may remain present in the container after sealing as well. Further, the conventional techniques are expensive, not precise and time consuming while attempting removal of oxygen and moisture from the containers, and they may require additional costly equipments as well. Some of the techniques involve including drying substance/ desiccants such as fish bone blister, silica gel desiccants, or Ca etc., however such chemicals react with humidity within the cavity of the containers and making the process more complex and final packaging very expensive and yet not very satisfactory to avoid migration of moisture and air into pack through sealed seam areas. Besides, conventional equipment used for sealing for example rotary and platen sealing tools have a special sealing geometry (knurs). The resultant packs accordingly would contain geometrical patterns allowing migration in and out of the cavity to happen via the open areas in the sealed layer which can’t be avoided.
[0006] Thus, the available methods/techniques and equipment do not provide an efficient solution to remove the air entering the packaging from the environment completely. Especially critical area around the filled product such as the areas of radius of the filled product and behind the product particularly in the cavities of the blister pack.
[0007] Therefore, there is a need in the art to provide an efficient, simple, and cost-effective method for removing moisture and/or oxygen completely from a container for storage of pharmaceutical products during packaging process to improve the shelf life of the products.
OBJECTS OF THE INVENTION
[0008] A general object of the present disclosure is to remove humid air completely from a container for storage of pharmaceutical products during packaging process to improve the shelf life of the products.
[0009] Another object of the present disclosure is to provide a method and system for removing oxygen and moisture from cavities of a container for storage of pharmaceutical products during packaging process to improve the shelf life of the products.
SUMMARY
[0010] The present invention relates to the field of packaging process of pharmaceutical products. In particular, it pertains to a method and system to remove humid air completely from a medical container for storage of pharmaceutical products during packaging process to improve the shelf life of the products.
[0011] In an aspect, the present disclosure provides a method for packaging of a pharmaceutical product in a container to remove one or more of air, oxygen and moisture from one or more cavities of the container, the method can include steps of: blowing, by a first fluid blowing unit, a fluid in the one or more cavities of the container to replace the oxygen and moisture from the one or more cavities; dispensing a product in each of the one or more cavities of the container; creating vacuum, by a vacuum unit, in the one or more cavities of the container; and blowing, by a second fluid blowing unit, the fluid in the one or more cavities of the container to replace residue oxygen and moisture from the one or more cavities of the container.
[0012] In an aspect, the disclosed method can include a step of sealing, using a sealing unit, the container by applying one or more sealing layers on the container at a sealing station.
[0013] In an aspect, the container is a blister pack, preferably a blister pack without any geometrical pattern to minimise avoid ingress or cross migration of one or more of air, oxygen and moisture through sealed seam area during the storage to increase the product shelf life.
[0014] In an embodiment, the fluid is any or a combination of dry air and inert gas.
[0015] In an embodiment, the product is an air and/or moisture sensitive product.
[0016] In an embodiment, the product is a pharmaceutical product selected from but not limiting to dosage form such as tablet, caplet, capsule, pill, lozenges, or like.
[0017] In an embodiment, blowing the fluid in the one or more cavities can be performed from any or a combination of a top of the container and from sides of the container to remove the oxygen and moisture from surrounding the filled products in the one or more cavities.
[0018] In an embodiment, vacuum creation and fluid blowing are performed to remove air and/or moisture especially from death areas/critical area such as area around the products (related to radius of the product) and behind the products in the cavities and filled up with any or a combination of the dry air and inert gas.
[0019] In an embodiment, each of the first fluid blowing unit and the second blowing unit can include one or more rows of openings to blow fluid streams in the one or more cavities.
[0020] In an embodiment, the openings of each of the one or more rows of openings can be arranged such that the fluid streams coming out of adjacent openings of the openings cross each other.
[0021] In an embodiment, the fluid streams to be blown are with the force and in direction such that the product would not change place in cavity and would not pose problem during sealing.
[0022] In an embodiment, the vacuum creation to be as strong such that filled product would not be taken out of cavity.
[0023] In an embodiment, the fluid blowing units can be made from material acceptable for pharmaceutical operation which does not contaminate the product and is not influenced by heat radiation from the sealing station.
[0024] In another aspect, the present disclosure provides a system for removing one or more of oxygen and moisture from one or more cavities of a container for storage of one or more pharmaceutical products, the disclosed system can include one or more fluid blowing units adapted to blow a fluid in the one or more cavities of the container to replace the oxygen and moisture from the one or more cavities, said one or more fluid blowing units can include one or more rows of openings to blow fluid streams in the one or more cavities; and a vacuum unit adapted to create vacuum in the one or more cavities of the container.
[0025] In an embodiment, the openings of each of the one or more rows of openings of the fluid blowing unit are arranged such that the fluid streams coming out of adjacent openings, of the openings cross each other.
[0026] In an embodiment, the fluid is any or a combination of dry air and inert gas.
[0027] In an embodiment, each of the one or more fluid blowing units is made of a temperature resistant polymeric material.
[0028] In an embodiment, according to the present disclosure the sealing unit can include flat sealing tools such as rollers or plates without sealing structures for example geometrical patterns (knurs) like dots, or lines thereon so that the air is completely removed between base and lid material which are compressed in a single line during sealing with minimum contact area. The resultant sealed pack without geometrical patterns like dots, lines or criss-cross patterns and less sealing area reduce or eliminate migration of air and/or humid air during storage which otherwise could ingress through the sealed area with geometrical patterns created with sealing tools known in the art.
[0029] Various objects, features, aspects and advantages of the inventive subject matter will become more apparent from the following detailed description of preferred embodiments, along with the accompanying drawing figures in which like numerals represent like components.
BRIEF DESCRIPTION OF THE DRAWINGS
[0030] The accompanying drawings are included to provide a further understanding of the present disclosure, and are incorporated in and constitute a part of this specification. The drawings illustrate exemplary embodiments of the present disclosure and, together with the description, serve to explain the principles of the present disclosure.
[0031] In the figures, similar components and/or features may have the same reference label. Further, various components of the same type may be distinguished by following the reference label with a second label that distinguishes among the similar components. If only the first reference label is used in the specification, the description is applicable to any one of the similar components having the same first reference label irrespective of the second reference label.
[0032] FIG. 1 illustrates an exemplary representation of a flow diagram of the method for packaging a container to remove oxygen and moisture from one or more cavities of the container, in accordance an embodiment of the present disclosure.
[0033] FIG. 2 illustrates an exemplary implementation of the system for removing oxygen and moisture from one or more cavities of a container for storage of one or more pharmaceutical products, in accordance with an embodiment of the present disclosure.
[0034] FIGs. 3A to 3D illustrates exemplary representation of a fluid blowing unit of the system for removing oxygen and moisture from one or more cavities of a container for storage of one or more pharmaceutical products, in accordance with an embodiment of the present disclosure.
DETAILED DESCRIPTION
[0035] As used in the description herein and throughout the claims that follow, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise.
[0036] In some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
[0037] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g. “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
[0038] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is herein deemed to contain the group as modified thus fulfilling the written description of all groups used in the appended claims.If the specification states a component or feature “may”, “can”, “could”, or “might” be included or have a characteristic, that particular component or feature is not required to be included or have the characteristic.
[0039] Exemplary embodiments will now be described more fully hereinafter with reference to the accompanying drawings, in which exemplary embodiments are shown. This disclosure may however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete and will fully convey the scope of the disclosure to those of ordinary skill in the art. Moreover, all statements herein reciting embodiments of the disclosure, as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents as well as equivalents developed in the future (i.e., any elements developed that perform the same function, regardless of structure).
[0040] Various terms as used herein are shown below. To the extent a term used in a claim is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.
[0041] Embodiment explained herein relates to a method and a system to remove one or more of air, oxygen and moisture completely from a medical container for storage of pharmaceutical products during packaging process to improve the shelf life of the products.
[0042] In an aspect, the present disclosure provides a method for packaging of a pharmaceutical product in a container to remove one or more of air, oxygen and moisture from one or more cavities of a container, the method can include steps of: blowing, by a first fluid blowing unit, a fluid in the one or more cavities of the container to replace the oxygen and moisture from the one or more cavities; dispensing a product in each of the one or more cavities of the container; creating vacuum, by a vacuum unit, in the one or more cavities of the container; and blowing, by a second fluid blowing unit, the fluid in the one or more cavities of the container to replace residue oxygen and moisture from the one or more cavities of the container.
[0043] In an aspect, the disclosed method can include a step of sealing, using a sealing unit, the container by applying one or more sealing layers on each of the one or more cavities of the container at a sealing station.
[0044] In an embodiment, the fluid is any or a combination of dry air and inert gas.
[0045] In an embodiment, the product is an oxygen (air) and/or moisture sensitive product.
[0046] In an embodiment, the product is a pharmaceutical product selected from but not limiting to dosage form such as tablet, caplet, capsule, pill, lozenges, or like.
[0047] In an embodiment, blowing the fluid in the one or more cavities can be performed from any or a combination of a top of the container and from sides of the container to remove the oxygen and moisture from surrounding the filled products in the one or more cavities.
[0048] In an embodiment, vacuum creation and fluid blowing are performed to remove air and/or moisture especially from death areas/critical area such as area around the products (related to radius of the products) and behind the product in the cavities and filled up with any or a combination of the dry air and inert gas.
[0049] In an embodiment, each of the first fluid blowing unit and the second blowing unit can include one or more rows of openings to blow fluid streams in the one or more cavities.
[0050] In an embodiment, the openings of each of the one or more rows of openings can be arranged such that the fluid streams coming out of adjacent openings of the openings cross each other.
[0051] In an embodiment, the fluid stream to be blown is with the force and in direction such that the product would not change place in cavity and would not pose problem during sealing.
[0052] In an embodiment, vacuum creation to be as strong such that filled product would not be taken out of cavity.
[0053] In another embodiment of the present disclosure provides a system for removing one or more of oxygen and moisture from one or more cavities of a container for storage of one or more pharmaceutical products, the disclosed system is based one or more fluid blowing units adapted to blow a fluid in the one or more cavities of the container to replace the oxygen and moisture from the one or more cavities, said one or more fluid blowing units can include one or more rows of openings to blow fluid streams in the one or more cavities; and a vacuum unit adapted to create vacuum in the one or more cavities of the container.
[0054] In an embodiment, each of the one or more fluid blowing units can include one or more rows of openings to blow fluid streams in the one or more cavities of the container for packaging. The openings of each of the one or more rows of openings of the fluid blowing unit can be arranged such that the fluid streams coming out of adjacent openings of the openings cross each other.
[0055] In an embodiment, the fluid blowing units can be made from material acceptable for pharmaceutical operation which does not contaminate the product and is not influenced by the heat radiation from sealing station.
[0056] Referring to FIG. 1, where a flow diagram of the proposed method for packaging of a pharmaceutical product in a container to remove oxygen and moisture from one or more cavities of the container is shown, the disclosed method 100, can include at a step 102, blowing, by a first fluid blowing unit, a fluid in the one or more cavities of the container to replace the oxygen and moisture from the one or more cavities of the container. Blowing of the fluid is performed prior to a sealing station. The fluid blowing unit blows the fluid for example as a kind of fluid curtain into the cavities and blows out the air from the container entering from the production environment.
[0057] In an embodiment, the fluid can be any or a combination of a dry air and inert gas.
[0058] In an embodiment, the disclosed method 100 can include at a step 104, dispensing a product in each of the one or more cavities of the container. The product is a pharmaceutical product selected from but not limiting to dosage form such as capsule, tablet, and the like.
[0059] In an embodiment, the disclosed method 100 can include at a step 106, creating vacuum, by a vacuum unit, in the one or more cavities of the container. Creation of vacuum in the cavities removes the air from surrounding of the filed product in the cavity such as area related to radius of the filled product and area behind the filled product.
[0060] In an embodiment, the created vacuum can be as strong such that the filled product remains at its position in the cavity and does not get displaced.
[0061] In an embodiment, the disclosed method 100 can include at a step 108, blowing, by a second fluid blowing unit, the fluid in the one or more cavities of the container to replace residual oxygen and moisture from the one or more cavities of the container. The area around the filled products in the cavities is filled with any of the dry air or inert gas results in about 100% replacement of the humidity and oxygen (humid air) is achieved.
[0062] In an embodiment, the fluid stream can be as strong such that the filled product remains at its place in the cavity.
[0063] In an embodiment, the blowing the fluid in the one or more cavities of the container can be performed from of top of the container or from side of the container based on requirement. Seam ???
[0064] In an embodiment, the disclosed method 100 can include at a step 110, sealing, using a sealing unit, the one or more cavities of the container by applying one or more sealing layers on each of the one or more cavities of the container at a sealing station. The sealing layer can be a lacquer, coating or film on the of aluminium and/or barrier material.
[0065] In an embodiment, the sealed container is a blister pack. As per one specific embodiment, the blister pack provided in accordance with the method of the present disclosure lacks any geometrical pattern on the sealed area to minimise / avoid ingress or migration of one or more of air, oxygen and moisture through sealed seam area during the storage to increase the product shelf life.
[0066] In an embodiment, each of the first fluid blowing unit and the second fluid blowing unit can be shaped of any of a tube, flat or rounded plate, and having one or more rows of openings to blow fluid streams in the one or more cavities. The openings of each of the one or more rows of openings can be arranged such that the fluid streams coming out of adjacent openings of the openings cross each other.
[0067] In an embodiment, each of the first fluid blowing unit and the second fluid blowing unit can be made of material which cannot contaminate the product and influenced by the heat radiation from the sealing station. In an embodiment, each of the first fluid blowing unit and the second fluid blowing unit can be made temperature resistance plastic such as polyoxymethylene (POM), polyamide, Teflon or medical approved metal.
[0068] FIG. 2 illustrates an exemplary implementation of the system for removing oxygen and moisture from one or more cavities of a container for storage of one or more pharmaceutical products, in accordance with an embodiment of the present disclosure. The system can include one or more fluid blowing units as a first fluid blowing unit 202-1 and a second fluid blowing unit 202-2 (collectively referred to as fluid blowing units 202) to blow a fluid in the one or more cavities such as a cavity 204-1 and 204-2 (collectively referred to as cavities 204) of a container/medial container 206 to replace the oxygen and moisture from the cavities 204, and a vacuum unit 208 to create vacuum in the cavities 202 of the container 206.
[0069] In an embodiment, each of the first fluid blowing unit and second fluid blowing unit can include one or more rows of openings (shown in FIG. 3) to blow fluid streams in the cavities 204.
[0070] In an embodiment, the openings of each of the one or more rows of openings of each of the first fluid blowing unit 202-1 and second fluid blowing unit 2020-2 can be arranged such that the fluid streams coming out of adjacent openings of the openings cross each other (shown in FIG. 3A and 3B).
[0071] In an embodiment, the fluid blowing units 202 are configured to blow fluid as fluid curtain into the cavities 204 and blow out the humid air from production environment.
[0072] In an embodiment, the fluid is any or a combination of dry air and inert gas.
[0073] In an embodiment, each of the one or more fluid blowing units is made of a temperature resistant polymeric material such as polyoxymethylene (POM), polyamide, Teflon or medical approved metal.
[0074] In an embodiment, the first fluid blowing unit 202-1 can be configured to blow fluid into the cavities 204 before filling of the product 214 in the cavities 204.
[0075] In an embodiment, the vacuum unit 208 is configured to create vacuum prior blowing inert gas or dry air in the cavities 202 before sealing of the cavities 204 at the sealing station 210 and after filling of the products in the cavities 204 of the container 206. The created vacuum can be as strong such that the filled product 214 remains at its position in the cavity.
[0076] In an embodiment, the second fluid blowing unit 202-2 can be configured to blow fluid into the cavity before sealing of the cavities 204 at a sealing station 210 by a sealing unit 212 and after filling of the products in the cavities 204 of the container 206. The fluid stream can be as strong such that the filled product 214 remains at its place in the cavity.
[0077] In an embodiment, the blowing the fluid in the one or more cavities of the container can be performed from of top of the container or from side of the container based on requirement.
[0078] In an embodiment, each of the first fluid blowing unit 202-1 and the second fluid blowing unit 202-2 can be shaped of any of a tube, flat or rounded plate.
[0079] In an embodiment, openings of each of the first fluid blowing unit 202-1 and the second fluid blowing unit 202-2 can be of in any geometry, and the geometry can be identical or a mix of two or more geometries.
[0080] In an exemplary embodiment, the vacuum unit 108 can be a tube shaped with all available and possible geometries such as round, oval, rectangular etc, or a bended sheet with a hollow space with openings, wherein the openings can be in one or multiple rows. The openings can be in any geometry, the geometry of the openings can be identical or a mix of two or more geometries.
[0081] Referring to FIGs. 3A to 3D, illustrate exemplary representations of a fluid blowing unit 202 of the system for removing oxygen and moisture from one or more cavities of a container for storage of one or more pharmaceutical products, in accordance with an embodiment of the present disclosure.
[0082] In an embodiment, according to the present disclosure there is provided a sealing unit can include flat sealing tools such as rollers or plates without sealing structures for example dots or geometrical patterns (knurs) thereon so that the air is completely removed between base and lid material which are compressed in a single line during sealing with minimum contact area. The resultant sealed pack without geometrical patterns like dots, lines or criss-cross pattern and less sealing area reduces or eliminates migration of air and/or humid air during storage which otherwise could ingress through sealed seam area with geometrical patterns created with sealing tools known in the art.
[0083] It should be apparent to those skilled in the art that many more modifications besides those already described are possible without departing from the inventive concepts herein. The inventive patient matter, therefore, is not to be restricted except in the spirit of the appended claims. Moreover, in interpreting both the specification and the claims, all terms should be interpreted in the broadest possible manner consistent with the context. In particular, the terms “includes” and “including” should be interpreted as referring to elements, components, or steps in a non-exclusive manner, indicating that the referenced elements, components, or steps may be present, or utilized, or combined with other elements, components, or steps that are not expressly referenced. Where the specification claims refers to at least one of something selected from the group consisting of A, B, C ….and N, the text should be interpreted as requiring only one element from the group, not A plus N, or B plus N, etc. The foregoing description of the specific embodiments will so fully reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and/or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the appended claims.
[0084] While embodiments of the present disclosure have been illustrated and described, it will be clear that the disclosure is not limited to these embodiments only. Numerous modifications, changes, variations, substitutions, and equivalents will be apparent to those skilled in the art, without departing from the spirit and scope of the disclosure, as described in the claims.
ADVANTAGES OF THE INVENTION
[0085] The present disclosure provides a system to remove humid air completely from a container for storage of pharmaceutical products during packaging process to improve the shelf life of the products.
[0086] The present disclosure provides an improved method for packaging a medial container to remove oxygen (air) and moisture from the container.
[0087] The present disclosure provides a method and system for removing oxygen and moisture from cavities of a container for storage of pharmaceutical products during packaging process to improve the shelf life of the products.
[0088] The present disclosure provides a simple and cost-effective method which can be easily implemented for packaging a medial container to remove oxygen and moisture from the container.
| Section | Controller | Decision Date |
|---|---|---|
| # | Name | Date |
|---|---|---|
| 1 | 201921039825-IntimationOfGrant17-05-2024.pdf | 2024-05-17 |
| 1 | 201921039825-STATEMENT OF UNDERTAKING (FORM 3) [01-10-2019(online)].pdf | 2019-10-01 |
| 2 | 201921039825-FORM 1 [01-10-2019(online)].pdf | 2019-10-01 |
| 2 | 201921039825-PatentCertificate17-05-2024.pdf | 2024-05-17 |
| 3 | 201921039825-DRAWINGS [01-10-2019(online)].pdf | 2019-10-01 |
| 3 | 201921039825-Annexure [14-05-2024(online)].pdf | 2024-05-14 |
| 4 | 201921039825-Written submissions and relevant documents [14-05-2024(online)].pdf | 2024-05-14 |
| 4 | 201921039825-DECLARATION OF INVENTORSHIP (FORM 5) [01-10-2019(online)].pdf | 2019-10-01 |
| 5 | 201921039825-Correspondence to notify the Controller [27-04-2024(online)].pdf | 2024-04-27 |
| 5 | 201921039825-COMPLETE SPECIFICATION [01-10-2019(online)].pdf | 2019-10-01 |
| 6 | Abstract1.jpg | 2019-10-05 |
| 6 | 201921039825-AMENDED DOCUMENTS [25-04-2024(online)].pdf | 2024-04-25 |
| 7 | 201921039825-Proof of Right (MANDATORY) [28-12-2019(online)].pdf | 2019-12-28 |
| 7 | 201921039825-Correspondence to notify the Controller [25-04-2024(online)].pdf | 2024-04-25 |
| 8 | 201921039825-FORM-26 [28-12-2019(online)].pdf | 2019-12-28 |
| 8 | 201921039825-FORM 13 [25-04-2024(online)].pdf | 2024-04-25 |
| 9 | 201921039825-FORM 18 [21-05-2021(online)].pdf | 2021-05-21 |
| 9 | 201921039825-MARKED COPIES OF AMENDEMENTS [25-04-2024(online)].pdf | 2024-04-25 |
| 10 | 201921039825-FER.pdf | 2022-03-16 |
| 10 | 201921039825-POA [25-04-2024(online)].pdf | 2024-04-25 |
| 11 | 201921039825-FER_SER_REPLY [16-09-2022(online)].pdf | 2022-09-16 |
| 11 | 201921039825-US(14)-HearingNotice-(HearingDate-29-04-2024).pdf | 2024-04-15 |
| 12 | 201921039825-CLAIMS [16-09-2022(online)].pdf | 2022-09-16 |
| 12 | 201921039825-CORRESPONDENCE [16-09-2022(online)].pdf | 2022-09-16 |
| 13 | 201921039825-CLAIMS [16-09-2022(online)].pdf | 2022-09-16 |
| 13 | 201921039825-CORRESPONDENCE [16-09-2022(online)].pdf | 2022-09-16 |
| 14 | 201921039825-FER_SER_REPLY [16-09-2022(online)].pdf | 2022-09-16 |
| 14 | 201921039825-US(14)-HearingNotice-(HearingDate-29-04-2024).pdf | 2024-04-15 |
| 15 | 201921039825-FER.pdf | 2022-03-16 |
| 15 | 201921039825-POA [25-04-2024(online)].pdf | 2024-04-25 |
| 16 | 201921039825-FORM 18 [21-05-2021(online)].pdf | 2021-05-21 |
| 16 | 201921039825-MARKED COPIES OF AMENDEMENTS [25-04-2024(online)].pdf | 2024-04-25 |
| 17 | 201921039825-FORM-26 [28-12-2019(online)].pdf | 2019-12-28 |
| 17 | 201921039825-FORM 13 [25-04-2024(online)].pdf | 2024-04-25 |
| 18 | 201921039825-Proof of Right (MANDATORY) [28-12-2019(online)].pdf | 2019-12-28 |
| 18 | 201921039825-Correspondence to notify the Controller [25-04-2024(online)].pdf | 2024-04-25 |
| 19 | Abstract1.jpg | 2019-10-05 |
| 19 | 201921039825-AMENDED DOCUMENTS [25-04-2024(online)].pdf | 2024-04-25 |
| 20 | 201921039825-Correspondence to notify the Controller [27-04-2024(online)].pdf | 2024-04-27 |
| 20 | 201921039825-COMPLETE SPECIFICATION [01-10-2019(online)].pdf | 2019-10-01 |
| 21 | 201921039825-Written submissions and relevant documents [14-05-2024(online)].pdf | 2024-05-14 |
| 21 | 201921039825-DECLARATION OF INVENTORSHIP (FORM 5) [01-10-2019(online)].pdf | 2019-10-01 |
| 22 | 201921039825-DRAWINGS [01-10-2019(online)].pdf | 2019-10-01 |
| 22 | 201921039825-Annexure [14-05-2024(online)].pdf | 2024-05-14 |
| 23 | 201921039825-PatentCertificate17-05-2024.pdf | 2024-05-17 |
| 23 | 201921039825-FORM 1 [01-10-2019(online)].pdf | 2019-10-01 |
| 24 | 201921039825-STATEMENT OF UNDERTAKING (FORM 3) [01-10-2019(online)].pdf | 2019-10-01 |
| 24 | 201921039825-IntimationOfGrant17-05-2024.pdf | 2024-05-17 |