PREPARATION METHOD OF ALDEHYDE COMPOUND
TECHNICAL FIELD [0001]
The present invention relates to a preparation method of an aldehyde compound, a preparation method of an amine compound and a preparation method of an isocyanate compound using the aldehyde compound obtained by the preparation method.
BACKGROUND ART [0002]
As a preparation method of an aldehyde compound using norbornene compound, for example, methods described in Patent Documents 1 to 3 are knovm. [0003]
Patent Documents 1 to 3 disclose methods for preparing formyl cyan norbornene by hydroformylating cyan norbornene using a mixed H2/CO gas in the presence of a catalyst. Patent Documents 1 and 2 disclose an example using a metal compound as a catalyst. Moreover, since it is possible to obtain a target compound v/ith high selectivity, and it is possible to suppress the reaction pressure to be low, a rhodium complex is preferably used as the catalyst. [0004]
Patent Document 1 describes that the catalyst may be used at 0.1% by v/eight to 10 % by weight with respect to cyan norbornene.

Patent Document 2 describes that v/ith the catalyst concentration of 0.5 mmol/l to 10 ramol/l, triarylphosphine can be used in a range of 3 moles to 300 moles with respect to 1 mole of rhodium. [0005]
Patent Document 4 discloses a method of hydroformylating an olefin-based compound using a mixed H2/CO gas in the presence of a transition metal catalyst and a trivalent phosphorus compound. Furthermore;, it is described that as the content of the metal catalyst, a free metal content is 10 ppm to 1,000 ppm based on the v/eight or volume of the catalyst composition. [0006]
Patent Document 5 describes a metal ligand complex catalyst, and exemplifies rhodium as a metal and an organic phosphorus ligand as a ligand. In addition, it is described that the amount of these used, in a case of calculating as a free metal, is a metal concentration in a range of about 1 ppm to 10,000 ppm, and a molar ratio of ligand:metal is 1:1 to 200:1.
In addition. Patent Document 6 discloses a method of preparing an aldehyde compound by hydroformylating a linear olefin compound. [0007]
In Examples of Patent Document 6, an example of hydroformylating 7-octenal in the presence of a rhodium catalyst and bisphosphite is described. In addition, it is described that about 3 ppmmol of rhodium is used with respect to 1 mole of 7-octenal, and rhodium atoms/phosphorus atoms ia 1/20 as a molar ratio. On the other hand, in paragraph 0084 of Patent Document 6, it is described that 2 moles to 1,000 moles in terms of phosphorus atom is preferable with respect

to 1 mole of a metal, and in a case of exceeding 1,000 moles, the reaction rate tends to be extremely lov7.
RELATED DOCUMENT PATENT DOCUMENT [0008]
[Patent Document 1] Japanese Laid-open Patent Publication No. 57-193438
[Patent Document 2] Japanese Laid-open Patent Publication No. 60-72844
[Patent Document 3] United States Patent No. 3,143,570
[Patent Document 4] Japanese Translation of PCT International Application No. 2010-538818
[Patent Document 5] Japanese Translation of PCT International Application No. 2003-505438
[Patent Document 6] Japanese Laid-open Patent Publication No. 2008-031125
DISCLOSURE OF THE INVENTION [0009]
In recent years, the amount of rare metal used has increased v;ith technological developments, and depletion of rare metal resources and rising prices have become a problem. Therefore, reducing the amount of so-called rare metals used and effective use thereof have been v/idely sought. [0010]
However, it is found that in the hydroformylation reaction of

a norbornene compound, for example, cyanonorbornene, v/hen reducing the amount of a metal compound which is a catalyst, a problem in productivity such as decrease in the reaction rate or decrease in the yield due to stopping of the reaction itself occurs. In industrial production, decrease in the reaction rate causes a problem in connection to the next step, and thus, production cannot be efficiently performed. [0011]
The present invention has been made in consideration of the above problems, and an object of the present invention is to provide an industrially advantageous method in which the amount of a metal which is an expensive catalyst is reduced, and which can suppress decrease in the reaction rate even in a case where the amount of the metal is reduced v;hen aldehyde is prepared.
[0012]
As a result of thorough studies of factors decreasing the reaction rate in order to solve the above problems, the present inventor found that when acrylonitrile is present in the reaction system, the reaction rate is decreased. Furthermore, the present inventor found that by controlling the amount of the acrylonitrile, it is possible to prepare aldehyde v/ithout a decrease in the reaction rate, and made the present invention.
The present invention can be described as follows.
[0013]
[1] A preparation method of an aldehyde compound having a step of reacting a compound represented by the following general formula
(al) V7ith hydrogen and carbon monoxide in the presence of a metal

compound including 0.01 ppmmol to 10 ppmmol of a metal belonging to Groups 8 to 10 with respect to 1 mole of the compound and a phosphorus compound, in which the amount of acrylonitrile included in the compound represented by the general formula (al) in the step is equal to or less than 200-fold by mole v/ith respect to 1 mole of the metal belonging to Groups 8 to 10.
(In the formula (al), n represents 0, 1, or 2.) [0014]
[2] The preparation method of an aldehyde compound according to [1], in v;hich the metal compound including the metal belonging to Groups 8 to 10 is a rhodium compound^ a cobalt compound, a ruthenium compound, or an iron compound.
[3] The preparation method of an aldehyde compound according to [1] or [2] , in v/hich the metal compound including the metal belonging to Groups 8 to 10 is a rhodium compound.
[4] The preparation method of an aldehyde compound according to any one of [1] to [3], in which the amount of the metal belonging to Groups 8 to 10 is 1 ppmmol to 5 ppmmol v/ith respect to 1 mole of the compound represented by the general formula (al).
[5] The preparation method of an aldehyde compound according to any one of [1] to [4], in v/hich the phosphorus compound is a trivalent phosphorus compound.

[6] The preparation method of an aldehyde compound according to any one of [Ij to [5], in which the compound represented by the general formula (al) is a compound represented by the following chemical formula (1) .
[0015]
[7] A preparation method of an amine compound, including a step of reacting the aldehyde compound obtained by the preparation method according to any one of [1] to [6] with ammonia, and v;ith hydrogen in the presence of a catalyst,
[8] A preparation method of an isocyanate compound including a step of reacting the amine compound obtained by the preparation method according to [7] v/ith a carbonylating agent. [0016]
Moreover, the "phosphorous compound" in the present invention means a phosphorous compound capable of forming a complex with a metal belonging to Groups 8 to 10.
In addition, in the present invention, in a case vAere a material B is used in the amount of 1 x 10"^ moles with respect to 1 mole of a material A, the amount of the material B is indicated as 1 ppmmol. [0017]
According to the preparation method of an aldehyde compound of the present invention, a decrease in the reaction rate generated when

the amount of metal v/hich is a catalyst is reduced is suppressed, and industrially advantageous preparation of an aldehyde compound can be achieved. Since the preparation method of an amine compound and the preparation method of an isocyanate compound of the present invention include the preparation method of an aldehyde compound as one step, according to the present invention, the effect is exhibited that productivity and yield of the isocyanate compound and the amine compound also are excellent.
BRIEF DESCRIPTION OF THE DRAWINGS [0018]
The above-described objects, other objects, features, and advantages v/ill be made clearer from the preferred embodiments described belov7, and the follov/ing accompanying drawings, [0019]
FIG. 1 is a ^H-NMR chart of the compound obtained in Example 1.
FIG. 2 is a -"-H-NMR chart of the compound obtained in Example 2.
FIG. 3 is a ■'"H-NMR chart of the compound obtained in Example 3.
DESCRIPTION OF EMBODIMENTS [0O2O]
Hereinafter, the preparation method of an aldehyde compound of the present embodiment will be described, and the preparation method of an amine compound, and then, the preparation method of an isocyanate compound will be described. [0021]
The compound represented by the follov/ing general formula (al)

(hereinafter, referred to as the compound (al)) used in the preparation method of an aldehyde compound of the present embodiment is synthesized through a Diels-Alder reaction of acrylonitrile and a compound having a conjugated double bond. [0022]
[0023]
In the formula (al), n represents 0, 1, or 2, and 0 or 1 is preferable, and 1 is more preferable.
Moreover, the compound (al) may be an endo compound or an exo compound, and may be a mixture including these in arbitrary proportions. [0024]
Examples of the compound having a conjugated double bond include butadiene, cyclopentadiene, and 1,3-cyclohexadiene. Moreover, since cyclopentadiene which is a raw material is present as dicyclopentadiene which is a dimer under the conditions of room temperature and atmospheric pressure, and the dicyclopentadiene is decomposed under the reaction conditions, producing cyclopentadiene, in general, dicyclopentadiene is used in the reaction. In the present embodiment, dicyclopentadiene is preferably used.
This step can be performed under the conditions of a reaction temperature of 100°C to 250''C and a reaction time of 0.1 hours to

10 hours. Acrylonitrile included in the compound (al) is an unreacted material in the preparation step. Specifically, an unreacted acrylonitrile is included in the reaction liquid obtained after synthesizing the compound (al). 5 [0025]
In the step, the amount of acrylonitrile is adjusted such that the amount of acrylonitrile in the synthesis step of an aldehyde compound described below becomes equal to or less than 200-fold by mole, preferably equal to or less than 140-fold by mole, and more
10 preferably equal to or less than 50-fold by mole v/ith respect to 1 mole of the metal belonging to Groups 8 to 10. Although the lower limit value is not particularly limited, the lower limit value is preferably equal to or greater than 0 . 05-fold by mole. When the lower limit value is the above value, the step of reducing the amount of
15 acrylonitrile is simple and does not influence productivity, and thus, it is preferable. Moreover, the upper limit value and the lov/er limit value can be suitably combined. [0026]
Specifically, a method of adjusting the above reaction
20 conditions or the amount of acrylonitrile as a raw material such that the amount of acrylonitrile included in the reaction liquid after synthesizing the compound (al) becomes the above amount, or a method of adjusting the amount of acrylonitrile to the above amount by reducing the amount of acrylonitrile included in the reaction liquid
25 after synthesizing the compound (al) can be exemplified. As the method of reducing the amount of acrylonitrile, distillation under decreased pressure, purification using a column, or the like can be

10
exemplified, however, the method is not particularly limited. [0027]

The compound (al) including acrylonitrile in a predetermined 5 range is allov/ed to react with hydrogen and carbon monoxide in the presence of "a metal compound including a metal belonging to Groups 8 to 10" in 0.01 ppramol to 10 ppmmol with respect to 1 mole of the compound (al) and a phosphorus compound. Specifically, the above reaction can be performed on the compound (al) in which the amount 10 of acrylonitrile is adjusted, in a state in which the amount of acrylonitrile in the reaction system is adjusted to the amount in the above range. [0028]
In the present embodiment, n of the compound (al) is more 15 preferably 1. Specifically, the compound is represented by the following chemical formula (1). [0029]
[0030] 20 Moreover, the compound represented by the chemical formula (1) may be an endo compound or an exo compound, and may be a mixture including these in arbitrary proportions.
The metal compound including a metal belonging to Groups 8 to

11
10 used in the reaction of the present embodiment is a rhodium compound, a cobalt compound, a ruthenium compound, or an iron compound. [0031]
Examples of the rhodium compound include Rh(acac)(00)2^ 5 Rh(acac)3, RhCl (CO) (PPha) 2, RhCKPPhaJs, RhBr (CO) (PPha) 2, Rh2(C0)8, Rh4(CO)i2, and Rh6(CO)i6, Examples of the cobalt compound include HCo (CO) 3/ HCo (CO) 4, C02 (CO) e, andHCos (CO) 9. Examples of the ruthenium compound include Ru(C0)3 (PPh3)2, RUCI2 (PPhs) 3/ RUCI3 (PPha) 3, and Rua (CO) 12. In addition, examples of the iron compound include Fe (CO) 5, 10 Fe(CO)4PPh3, and Fe (CO) 4 (PPh3) 2. Moreover, "acac" means acetylacetonato. [0032]
The rhodium compound used in the reaction of the present embodiment is not particularly limited as long as it is a compound 15 including monovalent rhodium metal, and rhodium carbonyl catalysts such as dicarbonylacetylacetonato rhodium (Rh(acac) (C0)2) / dodecacarbonyl tetrarhodium (Rh4(C0)i2), hexadecacarbonyl hexarhodium (Rhe(C0)i6), and octacarbonyl dirhodium (Rh2(CO)8); and rhodium chloride can be exemplified. 20 [0033]
The phosphorus compound used in the reaction of the present embodiment is not particularly limited as long as it is a trivalent phosphorus compound, and the compound represented by the following formula is preferably used. 25 (R^sP (R^0)3P In the above formula, R''' and R^ may be the same as or different

12
from each other, and each of R"^ and R^ represents an alkyl group having 1 to 16 carbon atoms or an aryl group having 6 to 16 carbon atoms which may have a substituent. [0034] 5 As the phosphorus compound, specifically, trivalent phosphorus compounds such as triphenyl phosphite, triphenyl phosphine, trimethyl phosphine, triethyl phosphine, tripropyl phosphine, tri(methyl benzene)phosphine, tri(ethyl benzene)phosphine, 1,2-bis(diphenyl phosphino)ethylene, 1,3-bis(diphenyl 10 phosphino)propane, 2,2-bis(diphenyl phosphino)-1,1-binaphthyl,
trimethoxy phosphite, triethoxy phosphite, tripropoxy phosphite, triisopropoxy phosphite, trimethylphenyl phosphite, and tris(2, 4-di-tert-butylphenyl) phosphite can be exemplified.
In the hydroformylation reaction using these rav/ materials, the 15 amount of metal belonging to Groups 8 to 10 to be used is 0.01 ppmmol to 10 ppmmol, and preferably 1 ppmmol to 10 ppmmol, and more preferably 1 ppmmol to 5 ppmmol with respect to 1 mole of the compound (al). When the amount is in the above numerical range, it is possible to ensure smooth progress of the reaction v/ithout excessively using an 20 expensive catalyst. [0035]
In addition, the amount of phosphorus compound used is preferably equal to or greater than 100-fold by mole, and more preferably equal to or greater than 100-fold by mole and equal to 25 or less than 10,000-fold by mole with respect to the metal belonging to Groups 8 to 10.
Moreover, the above numerical range can be combined arbitrarily.

13
[0036]
Synthesis of the aldehyde compound, specifically, can be performed in the follov/ing manner.
First, a rhodium compound, a phosphorus compound, and a compound 5 (al) which is a raw material are put in a reactor. While supplying hydrogen and a carbon monoxide gas thereto, the mixture is allowed to react at a temperature of 3D°C to 120° C and a pressure of 0.1 MPa to 1.0 MPa for 1 hour to 8 hours. Moreover, the hydroformylation reaction can be performed by suitably selecting a homogeneous
10 reaction system configured of only an oil phase or a two-layer reaction system configured of a water layer and an oil layer.
Thus, the compound (al) is hydroformylated, whereby an aldehyde compound is synthesized. [0037]
15 Moreover, the hydroformylation reaction can also be performed without a solvent, or can be performed using a substituted or unsubstituted aromatic compound, a substituted or unsubstituted aliphatic hydrocarbon compound, or alcohol, and for example, the hydroformylation reaction can also be performed in a solvent such
20 as toluene, benzene, hexane, octane, acetonitrile, benzonitrile, ortho-dichlorobenzene, ethanol, pentanol, or octanol. The hydroformylation reaction in the present embodiment is also excellent in reactivity at a high concentration, and thus, the hydroformylation reaction can be performed without a solvent. As a result, since a
25 step of distilling off a solvent or the like is not required, the step becomes simple, the volume efficiency also is improved, and the production efficiency also is excellent.

14
The aldehyde compound represented by the following general formula (bl) is synthesized from the compound of the general formula (al) by the preparation method of the present embodiment. [0038]
[0039]
In a case where n is 1 or 2, the compound represented by the general formula (bl) can be obtained as any one of "a compound in v/hich the 2-po3ition and the 5-position are substituted with
10 predetermined groups (hereinafter, referred to as a 2,5-isomer) " and "a compound in which the 2-position and the 6-position are substituted with predetermined groups (hereinafter, referred to as a 2, 6-isomer) ", or can be obtained as a mixture including these in arbitrary proportions. In addition^ each of the 2,5-isomer and the 2,6-isomer
15 can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions. [0040]
20 Moreover, in a case where n is 0, the compound represented by the general formula (bl) can be obtained as any one of a cis-type and a trans-type, or can also be obtained as a mixture including these in arbitrary proportions,

15
In the general formula (bl) , n is the same as that in the general formula (al) .
In the present embodiment, the compound represented by the general formula (bl) is preferably obtained, and as the compound, the compound represented by the following chemical formula (2) can be exemplified. [0041]
[0042]
10 Moreover, the aldehyde compound represented by the chemical formula (2) can be obtained as any one of "a compound in vfhich the 2-position of bicyclo [2.2.1] heptane is substituted with a cyano group and the 5-positlon is substituted with an aldehyde group (hereinafter, referred to as a 2, 5-isomer) " and "a compound in which the 2-position
15 is substituted v/ith a cyano group and the 6-position is substituted with an aldehyde group (hereinafter, referred to as a 2,6-isomer)", or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isom6r can be obtained as any one of an endo-endo compound, an endo-exo
20 compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least

16
tv/o types of these in arbitrary proportions,
After the hydroformylation reaction is finished, a target aldehyde compound can be obtained by performing a predetermined purification step. 5 [0043]

The preparation method of an amine compound of the present embodiment includes the f ollov/ing steps.
Step (a): Using the compound (al) including acrylonitrile in 10 a predetermined range, the compound (al) is allowed to react with hydrogen and carbon monoxide in the presence of a metal compound including a metal belonging to Groups 8 to 10 and a phosphorus compound.
Step (b): The aldehyde compound obtained in the step (a) is 15 reacted with ammonia, and reacted with hydrogen in the presence of a catalyst. [0044]
The preparation method of an amine compound of the present embodiment includes the preparation method of an aldehyde compound 20 described above as the step (a). Therefore, in the step (a), the aldehyde compound can be industrially advantageously prepared by the method in the present invention, and thus, improvement in the productivity and yield of the amine compound v^hich is a target compound becomes excellent. 25 Moreover, since the step (a) is the same as the step in the above-described "the preparation method of an aldehyde compound", the description thereof will not be repeated.

17
[0045]
In the step (b) , by performing imination by reacting the aldehyde compound obtained in the step (a) and represented by the general formula (bl) vjith ammonia and hydrogenation in the presence of a 5 catalyst, an amine compound is synthesized. [0046]
As the catalyst, metal catalysts such as nickel, platinum, palladium, and ruthenium can be used. In a case v/here the aldehyde compound has a cyano group as a substituent, a -CH2-NH2 group is 10 produced by hydrogen reduction. [0047]
In this manner, in the step (b), the aldehyde group of the aldehyde compound becomes an amino group by imination, and the cyano group also becomes an amino group by hydrogen reduction, and thus, 15 the amine compound represented by the following general formula (cl) having two amino groups is synthesized. [0048]
[0049] 20 In the formula (cl) , n is the same as that in the general formula (al).
In a case v/here n is 1 or 2, the compound represented by the general formula (cl) can be obtained as any one of "a compound in

which the 2-position and the 5-position are substituted v/ith predetermined groups {hereinafter, referred to as a 2,5-isomer) " and "a compound in which the 2-position and the 6-position are substituted with predetermined groups (hereinafter, referred to as a 2, 6-isomer} ", 5 or can be obtained as a mixture including these in arbitrary
proportions. In addition, each of the 2,.5-isomer and the 2, 6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least 10 tv;o types of these in arbitrary proportions. [0050]
Moreover, in a case where n is 0, the compound represented by the general formula (cl) can be obtained as any one of a cis-type and a trans type, or can also be obtained as a mixture including these 15 at an arbitrary proportion.
The compound of the general formula (cl) is preferably obtained, and as the compound, the compound represented by the follov/ing chemical formula (3) in which n is 1 can be exemplified. [0051]
20
[0052]
Moreover, the amine compound represented by the chemical formula (3) can be obtained as any one of "a compound in which the 2-position

19
and the 5-position of bicyclo[2.2.l]heptane are substituted with aminomethyl groups (hereinafter, referred to as a 2,5-isomer)" and "a compound in which the 2-position and the 6-position are substituted v/ith aminomethyl groups (hereinafter, referred to as a 2,6-isomer) ", 5 or can be obtained as a mixture including these in arbitrary
proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration of the substituent, or can be obtained as a mixture including at least 10 two types of these in arbitrary proportions. [0053]
The above imination and hydrogenation reaction, specifically, can be performed in the foilov/ing manner • First, an aldehyde compound, a solvent, and a catalyst are introduced into a reactor, and an ammonia 15 gas is blown thereinto. Furthermore, hydrogen is injected at a pressure until the pressure in the reactor becomes about 1 MPa, then, the temperature is raised to about 100"C, and the reaction is allov/ed to proceed for about 1 hour to 10 hours at this temperature and pressure v/hile supplying hydrogen. As the solvent, for example, an alcohol 20 having 1 to 8 carbon atoms or v;ater is preferably used.
Furthermore, after the reaction is finished, general catalyst filtration, desolventizing, and a purification step are performed, whereby a target amine compound can be obtained. [0054] 25
The preparation method of an isocyanate compound of the present embodiment includes the f ollov/ing steps.

20
Step (a): Using the compound (al) including acrylonitrile in a predetermined range, the compound (al) is allowed to react with hydrogen and carbon monoxide in the presence of a metal compound including a metal belonging to Groups 8 to 10 and a phosphorus 5 compound.
Step (b): The aldehyde compound obtained in the step (a) is reacted with ammonia, and reacted with hydrogen in the presence of a catalyst.
Step (c) : The amine compound obtained in the step (b) is reacted 10 v/ith a carbonylating agent. [0055]
The preparation method of an isocyanate compound of the present embodiment includes the preparation method of an aldehyde compound described above as the step (a) . Therefore, in the step (a), the 15 aldehyde compound can be industrially advantageously prepared by the method in the present invention, and thus, the productivity and yield of the isocyanate compound which is a target compound also become excellent. [0056] 20 Moreover, since the step (a) is the same as the step in the above-described "the preparation method of an aldehyde compound", and the step (b) is the same as the step in the above-described "the preparation method of an amine compound", the description thereof v/ill not be repeated. 25 [0057]
In the step (c) , by reacting the amine compound obtained in the step (b) represented by the general formula (cl) with a carbonylating

21
agent under predetermined conditions, an isocyanate compound represented by the follov/ing general formula (dl) is synthesized. As the carbonylating agent, phosgene, urea derivatives, carbonate derivatives, or carbon monoxide can be used. 5 [0058]
[0059]
In the formula (dl) , n is the same as that in the general formula (al).
10- In a case v;here n is 1 or 2, the compound represented by the general formula (dl) can be obtained as any one of "a compound in vjhich the 2-position and the 5-position are substituted with predetermined groups (hereinafter, referred to as a 2,5-isomer) " and "a compound in v;hich the 2-position and the 6-position are substituted
15 with predetermined groups (hereinafter, referred to as a 2, 6-isomer) ", or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound depending on a steric configuration
20 of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions. [0060]
Moreover, in a case where n is 0, the compound represented by

22
the general formula (dl) can be obtained as any one of a cis-type and a trans-type^, or can also be obtained as a mixture including these in arbitrary proportions.
The compound of the general formula (dl) is preferably obtained, and as the compound, the compound represented by the following chemical formula (4) in v/hich n is 1 can be exemplified. [0061]
[0062]
10 Moreover, the isocyanate compound represented by the chemical formula (4) can be obtained as any one of "a compound in v;hich the 2-position and the 5-position of bicyclo[2.2.1]heptane are substituted with isocyanatomethyl groups (hereinafter, referred to as a 2,5-isomer)" and "a compound in which the 2-position and the
15 6"position are substituted v/ith isocyanatomethyl groups (hereinafter, referred to as a 2,6-isomer)", or can be obtained as a mixture including these in arbitrary proportions. In addition, each of the 2,5-isomer and the 2,6-isomer can be obtained as any one of an endo-endo compound, an endo-exo compound, and an exo-exo compound
20 depending on a steric configuration of the substituent, or can be obtained as a mixture including at least two types of these in arbitrary proportions. [0063]

23
In a case of using phosgene as a carbonylating agent, as the step (c), specifically, a method in v/hich first, an amine compound and a solvent are introduced into a reactor, then, the mixture is subjected to a hydrochlorination reaction using hydrochloric acid 5 then, and reacted v/ith phosgene or a method in v/hich a carbamoyl chloride compound is obtained by directly reacting with phosgene, and the obtained carbamoyl chloride compound is subjected to a thermal decomposition can be exemplified. Furthermore, after the reaction is finished, a general purification step is performed, v/hereby a
10 target isocyanate compound can be obtained. [0064]
Moreover, although the reaction solvent in a case of using phosgene as a carbonylating agent is not particularly limited, an organic aromatic compound having a high boiling point or an ester
15 compound which has a high solubility of hydhydrochloric acid at the time of a salt formation reaction and a high solubility of phosgene and a lov/ solubility of hydhydrochloric acid at the time of a phosgenation reaction are preferably used. Examples of the organic aromatic compound having a high boiling point include
20 1,2-diethylbenzene, 1,3-diethylbenzene, 1,4-diethylbenzene, isopropylbenzene, 1,2,4-trimethylbenzene, amylbenzene, diamylbenzene, triamylbenzene, dodecylbenzene, p-cymene, cumene methylphenyl ether, ethylphenyl ether, diisoamyl ether, n-hexyl ether, ortho-dichlorobenzene, para-chlorotoluene, bromobenzene,
25 and 1,2,4-trichlorobenzene. In addition, although the ester
compound is not particularly limited, acetic esters such as isoamyl acetate and isooctyl acetate are preferable. Among these exemplified

24
solvents, a particularly preferred solvent for performing the present
invention is an aromatic halogen compound.
[0065]
The isocyanate compound obtained by the present embodiment can 5 be used as a raw material of optical materials or paint. Moreover,
the amine compound obtained by the present embodiment can be used
as paint or a rav/ material for a curing agent.
[Examples]
[0066] 10 Hereinafter, the present invention will be further described
in more detail with Examples, and the scope of the present invention
is not limited to Examples.
[0067]
[Reference Example] 15 [Synthesis of bicyclo[2.2.1]"5-heptene-2-carbonitrile]
195.0 g (1.40 mol) of dicyclopentadiene having a purity of 95%
and 163.6 g (3.08 mol) of acrylonitrile in which 0.36 g (1.8 mmol)
of N-nitrosodiphenylamine v;as added v/ere introduced into a 1,000 ml
autoclave, then, the mixture was allov/ed to react at 160°C for 5 hours 20 with stirring, and after the temperature was raised to 180°C and the
resultant product was allowed to react for 2 hours, the reaction was
finished. 355.6 g of reaction liquid including
bicyclo[2.2.1]-5-heptene-2-carbonitrile v;as obtained, and v/hen
analysis of the reaction liquid v/as performed, 331.2 g (2.78 mol) 25 of bicyclo [2.2.1] -5-heptene-2-carbonitrile was found to be contained
therein. 352.4 g of a reaction liquid including 328.2 g (2.75 mol)
of the obtained bicyclo[2.2.1]-5-heptene-2"carbonitrile was

25
obtained. [0068]
[Example 1]
[Synthesis of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 5 2-cyano-6"formyl bicyclo[2.2.1]heptane]
50.0 mg (0.194 mmol) of rhodium acetylacetonatodicarbonyl and 16.0 g (0.133 mol) of the bicyclo[2.2.1]-5-heptene-2-carbonitrile, and 1.2 g (3.87 mmol) of triphenyl phosphite were introduced into a glass container having an internal volume of 0 .1 L, then, the mixture 10 was stirred at 25°C, and a catalyst master liquid was adjusted. Then, 0.81 g (0.009 mmol in terms of Rh) of the catalyst master liquid and 218.6 g (1,8 mol) of bicyclo[2.2.1]-5"heptene-2-carbonitrile obtained as a main fraction by distilling the reaction liquid obtained by the method in Reference Example under decreased pressure, and 5 . 656 15 g (18.23 romol) of triphenyl phosphite were introduced into an
electromagnetic stirring type autoclave made of S[JS316IJ having an internal volume of 0. 5 L, and the mixture was stirred at 25°C, whereby 225.1 g of a Rh catalyst adjusting liquid v/as obtained. When the amount of acrylonitrile included in the 20 bicyclo[2.2.1]-5-heptene-2-carbonitrile at this time was measured by the following analytical method, the result was 0.1 ppm (0.0004 mmol) . The amount corresponds to 0.05-fold by mole with respect to 1 mole of rhodium.
Miount of rhodium used: 5 ppmmol with respect to 1 mole of 25 bicyclo[2.2.1]-5-heptene-2-carbonitrile [0069]
[Quantitative Analysis Method of Acrylonitrile]

26
GC model: GC-2014, manufactured by Shimadzu Corporation Column: DB~5, manufactured by J&W Scientific, inner diameter of 0.53 mm, length of 60 ra, and thickness of 1.5 \im
Temperature conditions : Column of 60°C, inlet of 150°C, detector
5 of aoo^c
Carrier gas: Nitrogen Injection volume: 1 pL [0070]
Then, after sufficiently replacing with nitrogen, replacement
10 by a mixed gas having a volume ratio of carbon monoxide/hydrogen of 50/50 v/as sufficiently performed. The same gas was supplied until the pressure in the autoclave became 0.6 MPaG, and under stirring, the temperature v/as raised to 80°C, v/hereby a hydroformylation reaction was started. Since the pressure in the autoclave was
15 decreased v/ith the progress of the reaction, the mixed gas was
continuously supplied such that the pressure v/as maintained at 0. 6 MPaG, the liquid temperature was adjusted so as to be maintained at 80°C, and a reaction v/as performed for 4.5 hours. After the reaction was finished, the mixed gas in the system v/as purged v;ith nitrogen,
20 whereby 275.0 g of a reaction liquid including 2-cyano-5, (6)-formyl bicyclo[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed, 259.4 g {1.74 mol) of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was found to be contained therein. The reaction yield was 96.7 mol%.
25 The results are shov/n in Table 1. [0071]
255.1 g (1.71 mol) of 2"cyano-5,(6)-formyl

27
bicyclo[2.2.1]heptane, 263.8 g of a reaction liquid including 4.7 g (0.02 mol) of triphenyl phosphite, and 14.0 g of water were introduced into a four^-neck reaction flask having an internal volume of 2 L equipped with a reflux condenser, a stirring blade, and a 5 thermometer, and after stirring the mixture, the temperature v/as raised to 80°C, and hydrolysis was performed for 2 hours. When analysis of the obtained solution v/as performed, 252.1 g (1.69 mol) 'hf 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was found to be contained therein, and 10 triphenyl phosphite was not detected.
6.4 g (0.012 mol) of 20% by weight aqueous potassium hydrogencarbonate solution of v;as added dropv/ise to the hydrolyzed solution so as to give pH of 7.0 at 25°C. [0072] 15 Then, distillation was performed under a decreased pressure, whereby 264 g of a solution including 250.6 g (1.68 mol) of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo [2 . 2 .1] heptane was obtained. The solution v/as purified by distillation under a decreased pressure, v/hereby 244.7 g (1.64 mol) 20 of a mixture of 2-cyano-5-formyl bicyclo[2.2.1]heptane and
2-cyano-6-formyl bicyclo [2 , 2 .1] heptane v/as obtained. The ''"H-NMR
chart of the mixture is shown in FIG. 1.
[0073]
[Example 2] 25 [Synthesis of 2,5~bisaminomethyl-bicyclo[2.2.1]heptane and 2, 6-bisaminomethyl-bicycIo[2.2.1]heptane]
89.5 g (0.6 mol) of 2-cyano-5-formyl bicyclo [2. 2 .1] heptane and

28
2-cyano-6"formyl bicycle[2.2.1]heptane obtained in Example 1, 89.5 g of methanol, and 4.5 g (dried mass) of a Raney cobalt catalyst (94% by mass of cobalt, 3.5% by mass of aluminum, and 2.1% by mass of manganese) obtained by developing a cobalt-aluminum alloy containing 5 manganese v/ere put into an electromagnetic stirring type autoclave made of stainless steel having an internal volume of 0.5 L, and 24.5 g (1.44 mol) of an ammonia gas was blown thereinto.
Then, after sufficiently replacing with nitrogen, replacement with hydrogen v?as performed. Furthermore, hydrogen v/as supplied
10 until the pressure in the autoclave became 1.2 MPaG, and under stirring, the temperature was raised to 100°C, whereby a reaction was started. Since the pressure in the autoclave was decreased with the progress of the reaction, hydrogen v;as continuously supplied such that the pressure v;as maintained at 1.2 MPaG, the liquid temperature was
15 adjusted so as to be maintained at 100"C, and a hydrogenation reaction v/as performed for 6 hours. [0074]
After cooling the resultant product to room temperature, the Raney cobalt catalyst v/as removed by filtration, and ammonia and
20 methanol v/ere distilled off at 4 kPa and 60°C, v/hereby 102.0 g of a solution including 2,5-bisaminomethyl-bicyclo[2.2.1]heptane and 2,6-blsaminomethyl-bicyclo[2.2.1]heptane was obtained.
102.0 g of the obtained solution including 2,5"bisaminomethyl-bicycle[2.2.1]heptane and
25 2,6~bisaminomethyl-bicyclo[2.2.1]heptane was introduced into a 200 mL flask, and distillation was performed under a decreased pressure, whereby 79.0 g of a purified mixture of

29
2, 5-bisaminomethyl-bicyclo[2.2.1]heptane and
2,6-bisaminomethyl-bicycle[2.2.1]heptane was obtained.
The ^H-NMR chart of the mixture is shown in FIG. 2, The same operation v/as repeated two times, whereby 158 g of a purified mixture 5 of 2,5"bisaminomethyl-bicyclo[2.2.Ijheptane and
2, 6-bisaminomethyl-bicycle [2,2 .1]heptane v/as obtained. [0075]
[Example 3]
[Synthesis of 2,5-bisisocyanatomethyl-bicyclo[2.2.l]heptane
10 and 2,6-bisisocyanatomethyl-bicyclo[2.2.1]heptane]
958 g of orthodichlorobenzene v/as introduced into a five-neck reaction flask having an internal volume of 2 L equipped with a reflux condenser, a stirring blade, a thermometer, a gas blowing tube, and a rav/ material introducing tube, and 154.2 g {1.0 mol) of
15 2,5-bisaminomethyl-bicyclo[2.2.1]heptane and
2,6-bisaminomethyl-bicycle[2.2.Ijheptane obtained in Example 2 and 702 g of orthodichlorobenzene v/ere put into a rav/ material tank. Then, after raising the temperature of a reaction flask to 120°C at 0.1 MPa, introductions of hydrochloric acid gas at a rate of 43.8 g/hr
20 from a hydrochloric acid blov/ing tube and an amine diluted with a solvent at a rate of 428.1 g/hr from the raw material tank through the raw material introducing pump into the reaction flask were started at the same time, and the entire amount v/as introduced over 2 hours. Furthermore, aging was performed for 1 hour while introducing a
25 hydrochloric acid gas at 20 g/hr. After the reaction was finished, the temperature of a hydrochloride reaction mass v/as raised to 160 °C, then, phosgene v/as blown in at 100 g/hr {1.0 mol/hr) from a phosgene

30
blowing tube, and the reaction was allov/ed to proceed for 6 hours while the temperature was maintained. After the reaction was finished, the unreacted phosgene and hydrochloric acid gas in the system were purged with nitrogen, and desolventizing was performed, 5 whereby 200.9 g of a solution including
2, 5"bisisocyanatomethyl-bicyclo[2.2.1]heptane and 2,6-bisisocyanatomethyl-bicyclo[2.2,l]heptane was obtained. Furthermore, distillation was performed under a decreased pressure, whereby 175.7 g of a mixture of
10 2,5-bisisocyanatomethyl-bicyclo[2.2.1]heptane and
2,6-bisisocyanatomethyl"bicyclo[2.2.1]heptane having a purity of 99,0% was obtained. The ^H-NMR chart of the mixture is shovm in FIG. 3. [0076]
15 [Example 4]
[Synthesis of 2-cyano-5-formyl bicyclo[2.2.l]heptane and 2-cyano-6"formyl bicyclo[2.2.1]heptane]
After a catalyst master liquid v-zas prepared in the same manner as in Example 1, 0.81 mg (0.009 mm.ol in terms of Rh) of the catalyst
20 master liquid and 218.9 g {1.8 mol) of
bicyclo [2.2.1] -5-heptene-2-carbonitrile obtained as a main fraction by distilling the reaction liquid obtained by the method in Reference Example under decreased pressure, and 5.656 g (18.23 mmol) of triphenyl phosphite v/ere introduced into an electromagnetic stirring
25 type autoclave made of SUS316L having an internal volume of 0.5 L, and the mixture was stirred at 25°C, whereby 225,4 g of a Rh catalyst adjusting liquid v/as obtained. When the amount of acrylonitrile

31
included in the bicycle [2.2.1] -5-heptene-2-carbonitrile at this time was measured by the above analytical method, the result v/as 101 ppm (0.417 mmol) . The amount corresponds to 46-fold by mole with respect to 1 mole of rhodium used. 5 Amount of rhodium used: 5 ppmmol with respect to 1 mole of bicycle[2.2.1]-5-heptene-2-carbonitrile [0077]
Then, after sufficiently replacing with nitrogen, replacement by a mixed gas having a volume ratio of carbon monoxide/hydrogen of
10 50/50 was sufficiently performed. The same gas v/as supplied until the pressure in the autoclave became 0. 6 MPaG, and under stirring, the temperature was raised to 80°C, whereby a hydroformylation reaction was started. Since the pressure in the autoclave was decreased with the progress of the reaction, the mixed gas was
15 continuously supplied such that the pressure v/as maintained at 0.6 MPaG, the liquid temperature v/as adjusted so as to be maintained at 80°C, and a hydroformylation reaction was performed for 4.9 hours. After the reaction was finished, the mixed gas in the system was purged with nitrogen, whereby 274,8 g of a reaction liquid including
20 2-cyanO"5-formyl bicyclo [2 . 2 . l]heptane and 2-cyano-'6"formyl
bicycle[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed, 260.9 g (1.75 mol) of the compounds v/as found to be contained therein. The reaction yield v/as 97.2 mol%. The results are shown in Table 1,
25 [0078]
[Example 5]
[Synthesis of 2-cyano-5-formyl bicyclo[2.2.1]heptane and

32
2-cyano-6"formyl bicyclo[2.2.1]heptane]
After a catalyst master liquid was prepared in the same manner as in Example 1, 0.81 mg (0.009 mmol in terms of Rh) of the catalyst master liquid and 218.4 g (1.8 mol) of 5 bicyclo [2.2.1] -5-heptene-2-carbonitrile obtained as a main fraction by distilling the reaction liquid obtained by the method in Reference Example under decreased pressure, and 5.656 g (18.23 mmol) of triphenyl phosphite were introduced into an electromagnetic stirring type autoclave made of SUS316L having an internal volume of 0.5 L,
10 and the mixture was stirred at 25°C, whereby 224.9 g of a Rh catalyst adjusting liquid v/as obtained. When the amount of acrylonitrile included in the bicyclo [2. 2.1] -5-heptene-2-carbonitrile at this time was measured under the above analysis conditions, the result was 201 ppm (0.827 mmol). The amount corresponds to 91-fold by mole with
15 respect to 1 mole of rhodium used.
Amount of rhodium used (condition (1)) : 5 ppimmol with respect to 1 mole of bicyclo[2.2.1]-5-heptene~2-carbonitrile [0079]
A hydroformylation reaction v/as performed for 5.8 hours u.nder
20 the same reaction conditions as in Example 4. After the reaction was finished, the mixed gas in the system was purged with nitrogen, whereby 274.0 g of a reaction liquid including 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed,
25 262.9g (1.76mol) of the compounds was found to be contained therein. The reaction yield was 97.8 mol%. The results are shovm in Table 1.

33
[0080]
[Example 6]
[Synthesis of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane] 5 After a catalyst master liquid v/as prepared in the same manner as in Example 1, 0.81 mg {0.009 mmol in terms of Rh) of the catalyst master liquid and 218.4 g (1.8 mol) of
bicyclo [2.2.1] -5-heptene-2-carbonitrile obtained as a main fraction by distilling the reaction liquid obtained by the method in Reference
10 Example under decreased pressure, and 5.656 g (18.23 mmol) of
triphenyl phosphite v/ere introduced into an electromagnetic stirring type autoclave made of SUS316L having an internal volume of 0.5 L, and the mixture was stirred at 25"C, whereby 224.9 g of a Rh catalyst adjusting liquid was obtained. When the amount of acrylonitrile
15 included in the bicyclo [2 .2.1] -5-heptene-2-carbonitrile at this time was measured under the above analysis conditions, the result was 302 ppm (1.239 mmol) . The amount corresponds to 137-fold by mole with respect to 1 mole of rhodium used.
Amount of rhodium used: 5 ppmmol with respect to 1 mole of
20 bicyclo[2.2.1]-5-heptene-2-carbonitrile [0081]
A hydroformylation reaction was performed for 5.6 hours under the same reaction conditions as in Example 4, After the reaction was finished, the mixed gas in the system was purged with nitrogen,
25 whereby 274.0 g of a reaction liquid including 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed,

34
261.2 g (1.75 mol) of the compounds was found to be contained therein. The reaction yield vjas 97.2 mol%. The results are shovm in Table 1.
[0082] 5 [Example 7]
[Synthesis of 2-cyano-5-formyl bicyclo[2.2.1]heptane and 2-cyano-6-formyl bicyclo[2,2.1]heptane]
After a catalyst master liguid was prepared in the same manner as in Example 1, 0.81 mg {0.009 mmol in terms of Rh) of the catalyst
10 master liquid and 218.4 g (1.8 mol) of
bicyclo [2 .2 .1] "5"heptene-2-carbonitrile obtained as amain fraction by distilling the reaction liquid obtained by the method in Reference Example under decreased pressure, and 5.656 g (18.23 mmol) of triphenyl phosphite were introduced into an electromagnetic stirring
15 type autoclave made of SUS316L having an internal volume of 0.5 L, and the mixture was stirred at 25°C, whereby 225.0 g of a Rh catalyst adjusting liquid v/as obtained. When the amount of acrylonitrile included in the bicyclo [2.2.1] -5"heptene-2-carbonitrile at this time was measured under the above analysis conditions, the result was 323
20 ppm (1.359 mmol). The amount corresponds to 150-fold by mole v/ith respect to 1 mole of rhodium used.
Amount of rhodium used: 5 ppmmol v/ith respect to 1 mole of bicyclo[2.2.1]-5-heptene-2-carbonitrile [0083]
25 A hydroformylation reaction was performed for 6.7 hours under the same reaction conditions as in Example 4. After the reaction was finished, the mixed gas in the system was purged with nitrogen,

35
whereby 276.0 g of a reaction liquid including 2-cyano"5"formyl bicyclo[2.2.1]heptane and 2-cyano~6"formyl bicycle[2.2.1]heptane was obtained. When analysis of the reaction liquid was performed, 258 . 3 g (1.73 mol) of the compounds was found to be contained therein. 5 The reaction yield was 96.3 mol%. The results are shov/n in Table 1. [0084]
[Example 8]
[Synthesis of 2-cyano--5-formyl bicyclo [2 . 2 .1] heptane and
10 2"cyano-6-formyl bicyclo[2.2,1]heptane]
After a catalyst master liquid was prepared in the same manner as in Example 1, 0.81 mg (0.009 mmol in terms of Rh) of the catalyst master liquid and 218.4 g (1.8 mol) of bicyclo [2.2.1] -5-heptene-2-carbonitrile obtained as a main fraction
15 by distilling the reaction liquid obtained by the method in Reference Example under decreased pressure, and 5.656 g (18.23 mmol) of triphenyl phosphite were introduced into an electromagnetic stirring type autoclave made of SUS316L having an internal volume of 0.5 L, and the mixture was stirred at 25°C, v/hereby 224.8 g of a Rh catalyst
20 adjusting liquid vias obtained. When the amount of acrylonitrile included in the bicyclo [2.2.1] -5-heptene-2-carbonitrile at this time was measured under the above analysis conditions, the result was 409 ppm (1.723 mmol) . The amount corresponds to 190-fold by mole with respect to 1 mole of rhodium used.
25 Amount of rhodium used: 5 ppramol v/ith respect to 1 mole of bicyclo[2.2.1]-5"heptene-2-carbonitrile [0085]

36
A hydroformylation reaction was performed for 6.8 hours under the same reaction conditions as in Example 4. After the reaction was finished, the mixed gas in the system was purged with nitrogen, whereby 278.3 g of a reaction liquid including 2-cyano-5-formyl 5 blcyclo[2.2.l]heptane and 2-cyano-6"formyl bicycle[2.2.IJheptane v/as obtained. When analysis of the reaction liquid was performed, 259.6 g (1.74 mol) of the compounds was found to be contained therein. The reaction yield was 96.4 mol%. The results are shown in Table 1.
10 [0086]
[Comparative Example 1]
[Synthesis of 2'cyano-5-formyl bicycle[2.2.1]heptane and 2-cyano-6-formyl bicycle[2.2.1]heptane]
After a catalyst master liquid v/as prepared in the same manner
15 as in Example 1, 0.81 rag (0.009 mmol in terms of Rh) of the catalyst master liquid and 219.6 g (1.8 mol) of
bicyclo [2.2.1] -5-heptene-2-carbonitrile obtained as a main fraction by distilling the reaction liquid obtained by the method in Reference Example under decreased pressure, and 5.656 g (18.23 mmol) of
20 triphenyl phosphite v/ere introduced into an electromagnetic stirring type autoclave made of SUS316L having an internal volume of 0.5 L, and the mixture was stirred at 25°C, whereby 226.1 g of a Rh catalyst adjusting liquid V7as obtained. When the amount of acrylonitrile included in the bicyclo [2 .2.1] -5"heptene"2-carbonitrile at this time
25 was measured under the above analysis condit ions, the result was 4 60 ppm (1.904 mmol) . The amount corresponds to 210-fold by mole v;ith respect to 1 mole of rhodium used.

Amount of rhodium used: 5 ppmmol with respect to 1 mole of bicyclo[2.2.1]-5-heptene-2-carbonitrile [0087]
A hydroformylation reaction was performed for 5,0 hours under the same reaction conditions as in Example 4. After the reaction was finished, the mixed gas in the system v/as purged with nitrogen, whereby 258.8 g of a reaction liquid including 2-cyano-5-formyl bicyclo[2.2.l]heptane and 2-cyano-6-formyl bicyclo[2.2.1]heptane was obtained. When analysis of the reaction liquid v/as performed, 190. 6 g (1.28 mol) of the compounds was found to be contained therein. The reaction yield was 71 mol%. The results are shown in Table 1.
In Examples 1 and 4 to 8, a high yield equal to or greater than 90% could be achieved at a reaction time of 4 hours to 7 hours, however, in Comparative Example 1, a yield at a reaction time of 5 hours was 71%. [0090]
This application claims priority from Japanese Patent Application No. 2012-247510 filed on November 9, 2012, the content Of which is incorporated herein by reference in its entirety,

CLAIMS
1. A preparation method of an aldehyde compound, comprising:
a step of reacting a compound represented by the following general formula (al) v/ith hydrogen and carbon monoxide in the presence of a metal compound including 0.01 ppmmol to 10 ppmmol of a metal belonging to Groups 8 to 10 with respect to 1 mole of the compound and a phosphorus compound^
wherein the amount of acrylonitrile included in the compound represented by the general formula (al) in the step is equal to or less than 200-fold by mole with respect to 1 mole of the metal belonging to Groups 8 to 10.
(In the formula (al) ^ n represents 0,. 1, or 2.)
2 . The preparation method of an aldehyde compound according to Claim
vjherein the metal compound including the metal belonging to Groups 8 to 10 is a rhodium compound, a cobalt compound, a ruthenium compound, or an iron compound.
3. The preparation method of an aldehyde compound according to Claim 1 or 2,

v/herein the metal compound including the metal belonging to Groups 8 to 10 is a rhodium compound.
4. The preparation method of an aldehyde compound according to any
one of Claims 1 to 3,
v/herein the amount of the metal belonging to Groups 8 to 10 is 1 ppmmol to 5 ppmmol v/ith respect to 1 mole of the compound represented by the general formula (al).
5. The preparation method of an aldehyde compound according to any
one of Claims 1 to 4,
wherein the phosphorus compound is a trivalent phosphorus compound.
6. The preparation method of an aldehyde compound according to any
one of Claims 1 to 5,
v/herein the compound represented by the general formula (al) is a compound represented by the following chemical formula (1).
7. A preparation method of an amine compound, comprising:
a step of reacting the aldehyde compound obtained by the preparation method according to any one of Claims 1 to 6 v;ith ammonia.

.and with hydrogen in the presence of a catalyst.
8. A preparation method of an isocyanatfs compound, comprising;
a step of reacting the amine compound obtained by the preparation 5 method according to Claim 7 with a carbonylating agent.