The following specification particularly describes the invention and the manner in which it is
to be performed.
FIELD OF THE INVENTION
[0001] The present invention relates to "Method for producing Direct Metal Glycinates and use of Direct Metal Glycinates and more particularly to Manufacturing of the same.
[0002] BACKGROUND OF THE INVENTION
[0003] The meaning of the method is described for producing acyl glycinate salts of formula
(ID
o
en)
R1 N COOB
H
in which Rl represents a saturated linear or branched alkyl radical comprising 1 to 21 carbon atoms or a monounsaturated or polyunsaturated linear or branched alkenyl radical comprising 2 to 21 carbon atoms, and B represents a cation, and/or the corresponding protonated acyl glycinic acid. Said method is characterized in that one or more fatty acid
monoethanol amides of formula (I)
(i) o
in which Rl has the meaning indicated above is/are oxidized with oxygen in the presence of an optionally supported bimetallic catalyst: consisting of gold and a metal from group VIII of the periodic table in the alkaline medium in order to obtain one or.more acyl glycinate salts of formula (II). In order to produce the protonated acyl glycinic acids, the acyl glycinate salt/s of formula (II). is/are additionally reacted with an acid.
[0004] Structural characterization of calcium glycinate. magnesium glycinate and zinc glycinate
Metal glycinate chelates are shaped by glycine and metal mixtures through synthetic responses. Calcium glycinate, magnesium glycinate and zinc glycinate are sorts of new-type and ideal supplement supplements, which have good physico-synthetic properties and bioactivities.
They are significant for prophylaxis and treat metal de~ciency. The primary portrayal shows that the metal particle is clung to the amino and carboxyl gathering to shape two "ve-membered rings. This paper predominantly concentrates on the construction portrayal of the metal chelated Glycinates by their solvency, infrared range, warm investigation, mass spectrometry, raction, the metal items and glycine items in calcium glycinate, magnesium glycinate and zinc glycinate.
[0005] The main objective of this invention is to utilise in the following sectors :
Metal glycinate chelates are framed by glycine and metal mixtures through compound responses,
and
are sorts of new-type and ideal supplement supplements, which have palatable physico-substance

properties and bioactivities. They are the crude materials of incredible amount of medical care items
having enormous market in China. In any case, they are confined in light of the fact that their designs not distinguished. Calcium glycinate, magnesium glycinate and zinc glycinate are framed by 2 to 1 chelate, and themetal particle is attached to the amino and carboxyl gathering to shape two "ve-membered rings.
Ion chromatography method was a high sensitivity, good accuracy method for the content analysis of metal ions.We used ion chromatographic methods to determine the metal ion contents of calcium glycinate and magnesium glycinate.10 But we could not determine zinc ion by the ion chromatography, so we used the inductively coupled plasma mass spectrometry (ICP-MS) to simultaneously determine the calcium, magnesium and zinc ion contents.11 The concentration of calcium and magnesium cations (Ca2b, Mg2p) was determined with a Dionex ICS-3000 dual system consisting of a dual pump (DP) module, an eluent generator (EG) module, a detector chromatography (DC) module (single temperature zone con'guration), and an autosampler (AS). The eluent contained 60 mmol/L sodium hydroxide (NaOH), and the °ow rate was 0.25 mL/min. Detection was the conductivity detector (CD) with integrated cell held at 350 C. The conductivity suppressor was CSRS ULTRA II (4 mm), the guard column was lonpac CG12A (cations) (4 0 50 mm), and the column was lonpac CS12A (cations) (4 D 250 mm). The concentrations of zinc cations (Zn2p) was carried out on an ICP-MS (ICP-MS X-7, Thermo Scienti'c), which was operated with the plasma screen plus sensitivity enhancement option "tted, Xt interface cones, and with Peltier cooling of the spray chamber. A standard quartz nebulizer was used, together with a standard quartz impact bead spray chamber and standard single piece,1.5 mm ID injector quartz torch. The instrument was operated using standard instrument operation. Plasma Lab software was applied to instrument control, data acquisition, and analysis. The instrumental and operating condition were optimized with the commentated tune solution. The operating parameters of ICP-MS instrument were as follows: RF power 1830W, coolant gas °ow 14.3 L/min, auxiliary gas °ow 0.95 L/min, nebulizer gas °ow 0.87 L/min, pump rate 1.0 mL/min, and peak jumping data acquisition mode: dwell time 10 s, duration time 60 s, and three replicates per sample. The isotope of SC (IS) was monitored at m/z 45, full validation according to the FDA guidelines was, as far as applicable for ICP-MS, performed for the assay.
SUMMARY OF THE INVENTION
[0006] METHOD FOR THE PRODUCTION OF ACYL GYLCINATES BY
MEANS OF DIRECT OXIDATION
[0007] A strategy is portrayed for delivering acyl glycinate salts of recipe (II) in which Rl addresses a soaked direct or expended alkyl extremist containing 1 to 21 carbon molecules or a monounsaturated or polyunsaturated straight or stretched alkenyl revolutionary involving 2 to 21 carbon particles, and B addresses a cation, or potentially the relating protonated acyl glycinic corrosive. Said strategy is portrayed in that at least one unsaturated fat monoethanol amides of recipe (I) in which Rl has the significance shown above is/are oxidized with oxygen within the sight of an alternatively upheld bimetallic impetus comprising of gold and a metal from bunch VIII of the intermittent table in the antacid medium to get at least one acyl glycinate salts of equation (II). To create the protonated acyl glycinic acids, the acyl glycinate salt/s of equation (II) is/are also responded with a corrosive.
[0008] The Manufacturing Process: Preparation of Sodium Acylglvcinates According to the Prior Art.
[0009] This process according to the prior art requires a relatively expensive and reactive raw material, namely the fatty acid chloride, and has the further disadvantage that one mole of sodium chloride NaCI is formed per mole of amino acid surfactant, i.e. the compound of the

formula (lla). This sodium chloride goes into the wastewater from the reaction and there represents a problem for biological water treatment plants since sodium chloride can impair the purification performance of such plants.
[0010] There is thus a need for a process for preparing amino acid surfactants, especially amino acid surfactants based on the amino acid glycine, known as acylglycinates and their protonated parent acids, which do not have the abovementioned disadvantages.
[0011] It has surprisingly been found that acylated glycines and salts thereof, known as acylglycinate salts or acylglycinates for short, can also be obtained, as an alternative to the customary fatty acid chloride route according to the prior art, by direct oxidation of fatty acid monoethanolamides by means of atmospheric oxygen or pure oxygen in the presence of transition metal catalysts.

A manufacturing method for producing Direct Metal Glycinates and use of Direct Metal Glycinates, the Metal amino acid chelates are produces by metal salts and glycine amino acid produced insitu the glycine is synthesized by chemical reaction after purification the insitu glycine amino acid is further converted into amino acid chelate by its reaction with 'metal oxide / hydroxide etc, the mentioned method is economical scalable without effluent and required much less energy;
The method as claimed in claiml, further comprises the preparing amino chelates that are free of interfering ions, and optionally, electrically neutral. In one embodiment, the compsosition is prepared by reacting in an aqueous solution a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a metal amino acid chelate andan essentially'inert calcium sulfate,
The method as claimed in claiml, further comprises processing the producing acyl glycinate
salts of formula (II) ? , v .
TO
A
N COOB
H

-.in which Rl represents a saturated linear or branched alkyl radical comprising 1 to 21 carbonratoms'6rVmonouhsaturated or polyunsaturated linear or branchedlilkenyl radical comprising 2 to 21 carbon atoms, and B represents a cation, and/or the corresponding protonated acyl glycinic acid. Said method is characterized in that one or more fatty acid
"monoethanol amides of formula (I)-

(i)
,OH * *- - * M
in which R1 has .the meaning indicated above is/areoxidized withoxygen in the presence :. v- of an optionally "supported bimetallic catalyst consisting of gold andalnetal from group VIII of the periodic table in the alkaline medium in order to obtain one or more acyl glycinate salts of formula (II). In order to produce the protonated acyl glycinic acids, the acyl glycinate salt/s of formula (II) is/are additionally reacted with an acid. The method as claimed in claiml, further comprises the composition can be prepared by reacting in an aqueous solution, a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially alLof the, ions present iii solution to react.forming a ., 1 positively charged metal amino acid chelate having a hydroxide counter-ion, and a calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 1:1 to 2:1.
The method as claimed in claiml, further comprises compositions and methods of preparing a ino acid chelates that are essentially free of interfering ions with the proviso a hydroxide ion is not *■ considered to be interfering. Alternatively, amino acid chelates that areteiectrically neutral and do _ . not containjiydroxide complex ions can also be formed