Method For Producing High Purity Ceramide

Abstract: Provided is a method for producing an optically active ceramide by an N acylation (amidation) reaction of an optically active aminodiol wherein a crude ceramide produced therein is purified by an industrially advantageous process. Namely provided is a method for producing a high purity ceramide that has high diastereo purity with high yield. A high purity ceramide is produced by: a step wherein a ceramide represented by general formula (1) is produced by reacting an aminodiol with an alkyl ester having 1 5 carbon atoms of an aliphatic carboxylic acid having 12 24 carbon atoms said aliphatic carboxylic acid optionally having a hydroxyl group in a hydrocarbon solvent having 5 10 carbon atoms; and a step wherein an alcohol having 1 3 carbon atoms is added into the reaction mixture obtained in the preceding step thereby causing crystals to precipitate. (In the formula R represents an alkyl group which has 13 17 carbon atoms and optionally has a carbon carbon unsaturated bond; R represents an alkyl group which has 11 23 carbon atoms and optionally has a hydroxyl group; and * represents an optically active state.)

Patent Information

Application #

Filing Date

03 June 2014

Publication Number

27/2015

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

TAKASAGO INTERNATIONAL CORPORATION

37 1 Kamata 5 chome Ohta ku Tokyo 1448721 Japan

Inventors

1. ISHIDA Kenya

c/o TAKASAGO INTERNATIONAL CORPORATION 37 1 Kamata 5 chome Ohta ku Tokyo 1448721

2. YAGI Kenji

c/o TAKASAGO INTERNATIONAL CORPORATION 4 11 Nishiyawata 1 chome Hiratsuka shi Kanagawa 2540073

Specification

Documents

Application Documents

#	Name	Date
1	1086-MUMNP-2014-ENGLISH TRANSLATION-(30-04-2015).pdf	2015-04-30
2	1086-MUMNP-2014-CORRESPONDENCE-(30-04-2015).pdf	2015-04-30
3	spec.pdf	2018-08-11
4	form5.pdf	2018-08-11
5	form3.pdf	2018-08-11
6	ABSTRACT1.jpg	2018-08-11
7	1086-MUMNP-2014.pdf	2018-08-11
8	1086-MUMNP-2014-OTHERS-310815.pdf	2018-08-11
9	1086-MUMNP-2014-OTHERS-140815.pdf	2018-08-11
10	1086-MUMNP-2014-OTHERS-040915.pdf	2018-08-11
12	1086-MUMNP-2014-OTHER DOCUMENT-240215.pdf	2018-08-11
13	1086-MUMNP-2014-FORM PCT-ISA-237(26-8-2014).pdf	2018-08-11
14	1086-MUMNP-2014-FORM PCT-IB-338(26-8-2014).pdf	2018-08-11
15	1086-MUMNP-2014-Form 3-310815.pdf	2018-08-11
16	1086-MUMNP-2014-FORM 3(9-10-2014).pdf	2018-08-11
17	1086-MUMNP-2014-FORM 26(6-6-2014).pdf	2018-08-11
18	1086-MUMNP-2014-FORM 1(6-6-2014).pdf	2018-08-11
19	1086-MUMNP-2014-ENGLISH TRANSLATION(2-7-2014).pdf	2018-08-11
20	1086-MUMNP-2014-Correspondence-310815.pdf	2018-08-11
21	1086-MUMNP-2014-CORRESPONDENCE-240215.pdf	2018-08-11
22	1086-MUMNP-2014-Correspondence-140815.pdf	2018-08-11
23	1086-MUMNP-2014-Correspondence-040915.pdf	2018-08-11
24	1086-MUMNP-2014-Correspondence-010615.pdf	2018-08-11
25	1086-MUMNP-2014-CORRESPONDENCE(9-10-2014).pdf	2018-08-11
26	1086-MUMNP-2014-CORRESPONDENCE(6-6-2014).pdf	2018-08-11
27	1086-MUMNP-2014-CORRESPONDENCE(26-8-2014).pdf	2018-08-11
28	1086-MUMNP-2014-CORRESPONDENCE(2-7-2014).pdf	2018-08-11