“Methods For Isolating Propargylated Aminoindans”

Abstract: Disclosed is a process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan having the structure (I) wherein R1 is H, hydroxyl, alkoxy or (II) wherein Y is 0 or S; R2 and R3 is each independently, C1-8 alkyl, C6-12 aryl, C6-12 aralkyl, each optionally halo substituted, or hydrogen ; where the reaction mixture further comprises a solven, a primary aminoindan having the structure (III) wherein R1 is defined as above, and a tertiary aminoindan having the structure (IV) the process comprising d) adding an acid to the reaction mixture; e) crystallizing the mono-propargylated aminoindan under conditions suitable for the formation of a crystalline salt of the mono-propargylated aminoindan ; and f) recovering the crystall...

Patent Information

Application #

Filing Date

28 May 2008

Publication Number

12/2009

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

TEVA PHARMACEUTICAL INDUSTRIES, LTD

5 Basel Street P.O.Box 3190 49131 Petach-Tikva Israel.

Inventors

1. FRENKEL, Anton

2/20 Shlomo Ha-Meleh Street 42268 Netanya Israel

2. LIDOR-HADAS, Ramy

19 Mor Street Kafar-Saba 44242 Israel

3. GUREVICH, Eduard

60/1 Kironi Street 49390 Petach-tikva Israel

4. ATTILI, Gsan

P.O.B 2034 44915 Tire Israel

Specification

PLEASE SEE THE SPECIFICATION ATTACHED.

Documents

Orders

Section	Controller	Decision Date

Application Documents

#	Name	Date
1	4541-delnp-2008-Form-18 (09-11-2009).pdf	2009-11-09
1	4541-delnp-2008.pdf	2018-07-23
2	4541-DELNP-2008_EXAMREPORT.pdf	2016-06-30
2	4541-delnp-2008-Correspondence-Others (09-11-2009).pdf	2009-11-09
3	Form-5.pdf	2011-08-21
3	4541-delnp-2008-Abstract-(12-09-2014).pdf	2014-09-12
4	Form-3.pdf	2011-08-21
4	4541-delnp-2008-Claims-(12-09-2014).pdf	2014-09-12
5	Form-1.pdf	2011-08-21
5	4541-delnp-2008-Correspondence Others-(12-09-2014).pdf	2014-09-12
6	Drawings.pdf	2011-08-21
6	4541-delnp-2008-Drawings-(12-09-2014).pdf	2014-09-12
7	4541-delnp-2008-Form-3-(31-03-2014).pdf	2014-03-31
7	4541-delnp-2008-Form-2-(12-09-2014).pdf	2014-09-12
8	4541-delnp-2008-Correspondence Others-(31-03-2014).pdf	2014-03-31
9	4541-delnp-2008-Form-3-(31-03-2014).pdf	2014-03-31
9	4541-delnp-2008-Form-2-(12-09-2014).pdf	2014-09-12
10	4541-delnp-2008-Drawings-(12-09-2014).pdf	2014-09-12
10	Drawings.pdf	2011-08-21
11	Form-1.pdf	2011-08-21
11	4541-delnp-2008-Correspondence Others-(12-09-2014).pdf	2014-09-12
12	Form-3.pdf	2011-08-21
12	4541-delnp-2008-Claims-(12-09-2014).pdf	2014-09-12
13	Form-5.pdf	2011-08-21
13	4541-delnp-2008-Abstract-(12-09-2014).pdf	2014-09-12
14	4541-DELNP-2008_EXAMREPORT.pdf	2016-06-30
14	4541-delnp-2008-Correspondence-Others (09-11-2009).pdf	2009-11-09
15	4541-delnp-2008.pdf	2018-07-23
15	4541-delnp-2008-Form-18 (09-11-2009).pdf	2009-11-09