“Methods For Preparing Eszopiclone Crystalline Form A Substantially

“Methods For Preparing Eszopiclone Crystalline Form A Substantially Pure Eszopiclone And Optically Enriched Eszopiclone”

Abstract: The present invention provides methods for preparing eszopiclone Form A, substantially chemically pure eszopiclone, or eszopiclone with low level(s) of residual solvent(s). The present invention also provides eszopiclone with low level(s) of residual solvent(s). The present invention also provides a process for optical enrichment of eszopiclone free base. For instance, one of the embodiments of the invention is directed to a method of preparing eszopiclone Form A, wherein the method comprises crystallizing eszopiclone free base from a solvent selected from the group consisting of isopropanol (IPA), methyl isobutyl ketone (MIBK), acetone, n-butanol, i-butanolisobutanol, 2-butanol, tetrahydrofuran (THF), dimethyl carbonate, methanol, ethanol,...

Patent Information

Application #

Filing Date

29 September 2008

Publication Number

21/2009

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

TEVA PHARMACEUTICAL INDUSTRIES LTD.

5 Basel Street P.O. Box 3190 Petah Tiqva

Inventors

1. MARIOARA MENDELOVICI

Elyezer Ben-Yehuda 16/20 Rehovot

2. ANITA LIBERMAN

14 Michael Neeman Tel-Aviv

3. ALEX MAINFELD

Hapardes 7A/2 Kfar-saba

4. NINA FINKELSTEIN

Katzenelson St. 23B/17 Herzliya 46290

Specification

see the attachment

Documents

Application Documents

#	Name	Date
1	8148-DELNP-2008_EXAMREPORT.pdf	2016-06-30
1	Translation-Search Report.pdf	2011-08-20
2	Form-1.pdf	2011-08-20
2	Priority Document.pdf	2011-08-20
3	Power of Authority.pdf	2011-08-20
5	Power of Authority.pdf	2011-08-20
6	Form-1.pdf	2011-08-20
6	Priority Document.pdf	2011-08-20
7	8148-DELNP-2008_EXAMREPORT.pdf	2016-06-30
7	Translation-Search Report.pdf	2011-08-20