Modulating Apolipoprotein (A) Expression


Updated over 1 year ago

Abstract

Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments the apo(a) targeting oligomeric compounds are conjugated to N- Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat prevent or ameliorate diseases disorders or conditions related to apo(a) and/or Lp(a). Certain diseases disorders or conditions related to apo(a) and/or Lp(a) include inflammatory cardiovascular and/or metabolic diseases disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases disorders or conditions in an individual in need thereof.

Information

Application ID 201847020374
Invention Field CHEMICAL
Date of Application 2018-05-31
Publication Number 23/2018

Applicants

Name Address Country Nationality
IONIS PHARMACEUTICALS, INC. 2855 Gazelle Court, Carlsbad, CA 92010, USA U.S.A. U.S.A.

Inventors

Name Address Country Nationality
VINEY, Nicholas, J. 2855 Gazelle Ct, Carlsbad, CA 92010. U.S.A. U.K.
GEARY, Richard, S. 2855 Gazelle Ct, Carlsbad, CA 92010. U.S.A. U.S.A.
WANG, Yanfeng 2855 Gazelle Ct, Carlsbad, CA 92010. U.S.A. U.S.A.
YU, Zhengrong 2855 Gazelle Ct, Carlsbad, CA 92010. U.S.A. U.S.A.
GUNAWAN, Rudy 2855 Gazelle Ct, Carlsbad, CA 92010. U.S.A. Indonesia

Specification

Documents

Name Date
201847020374-AMENDED DOCUMENTS [05-03-2020(online)].pdf 2020-03-05
201847020374-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [31-05-2018(online)].pdf 2018-05-31
201847020374-COMPLETE SPECIFICATION [31-05-2018(online)].pdf 2018-05-31
201847020374-DECLARATION OF INVENTORSHIP (FORM 5) [31-05-2018(online)].pdf 2018-05-31
201847020374-DRAWINGS [31-05-2018(online)].pdf 2018-05-31
201847020374-FER.pdf 2022-06-15
201847020374-FORM 1 [31-05-2018(online)].pdf 2018-05-31
201847020374-FORM 13 [05-03-2020(online)].pdf 2020-03-05
201847020374-FORM 18 [05-11-2019(online)].pdf 2019-11-05
201847020374-FORM 3 [08-11-2018(online)].pdf 2018-11-08
201847020374-FORM 3 [09-12-2022(online)].pdf 2022-12-09
201847020374-FORM 3 [26-09-2019(online)].pdf 2019-09-26
201847020374-FORM 3 [29-04-2019(online)].pdf 2019-04-29
201847020374-FORM 4(ii) [09-12-2022(online)].pdf 2022-12-09
201847020374-Information under section 8(2) [09-12-2022(online)].pdf 2022-12-09
201847020374-POWER OF AUTHORITY [31-05-2018(online)].pdf 2018-05-31
201847020374-PRIORITY DOCUMENTS [31-05-2018(online)].pdf 2018-05-31
201847020374-PROOF OF RIGHT [31-05-2018(online)].pdf 2018-05-31
201847020374-RELEVANT DOCUMENTS [05-03-2020(online)].pdf 2020-03-05
201847020374-SEQUENCE LISTING(PDF) [31-05-2018(online)].pdf 2018-05-31
201847020374-STATEMENT OF UNDERTAKING (FORM 3) [31-05-2018(online)].pdf 2018-05-31
201847020374-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [31-05-2018(online)].pdf 2018-05-31
abstract 201847020374.jpg 2018-06-04
Correspondence by Agent_Assignment_12-06-2018.pdf 2018-06-12

Orders

Applicant Section Controller Decision Date URL