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Mosquito Repellent Composition

Abstract: The present invention relates to an insect repellent composition. The present invention more particularly relates to a mosquito repellent composition comprising naturally derived oils.

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Patent Information

Application #
Filing Date
06 March 2023
Publication Number
37/2024
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application

Applicants

UPL LIMITED
UPL House, 610 B/2, Bandra Village, off Western Express Highway, Bandra-East, Mumbai 400 051, Maharashtra, India

Inventors

1. SHUKLA, Deepak
UPL House, 610 B/2, Bandra Village, off Western Express Highway, Bandra-East, Mumbai 400051, Maharashtra, India
2. LOKHANDE, Pradnya
UPL House, 610 B/2, Bandra Village, off Western Express Highway, Bandra-East, Mumbai 400051, Maharashtra, India
3. SRIVASTAVA, Krishna
UPL House, 610 B/2, Bandra Village, off Western Express Highway, Bandra-East, Mumbai 400051, Maharashtra, India

Specification

DESC:
FIELD OF THE INVENTION
The present invention relates to an insect repellent composition. The present invention more particularly relates to a mosquito repellent composition comprising naturally derived oils.

BACKGROUND OF THE INVENTION
Insect-borne illnesses are a significant contributor to sickness and mortality globally. Some insects are dangerous and can injure people by causing skin rashes, infections, and even diseases. Numerous products have been created to help us defend ourselves against these insects. These products were created with the intention of killing, preventing reproduction or proliferation, and weakening sensory systems to impair perception.

Mosquitoes are regarded as the most dreaded of all the insects that spread disease. In terms of hygiene, mosquitoes are a particularly dangerous bug since they carry pathogens that can lead to diseases like dengue, yellow fever, encephalitis, and malaria. It is difficult to deny that the mosquito is a dangerous, lethal bug, especially considering the fact that millions of people die from malaria each year throughout the world.

It is preferable to use a mosquito repellent to ward off mosquitoes because it poses no risk to human health. There are numerous insect repellents available. In particular, N,N-diethyl-m-toluamide (DEET) has become popular due to its highly effective ability to deter mosquitoes. However, DEET has been prohibited from use on kids, pregnant women, nursing mothers, hypotensive patients, people with sensitive skin, and other groups due to its pungent odour and high skin penetration.

N,N-diethyl benzamide (DEBA), a multipurpose insect repellent approved for direct application to human skin, clothing, household pets, tents, bedrolls, and screens, is another option for repelling mosquitoes.

DEET & DEBA are currently the most effective mosquito repellents and are available in various commercial compositions containing as high as up to 95% DEET content. Although insect repellents containing DEET and DEBA are efficient at preventing mosquito bites, they have also been linked to cancer, birth defects, headaches, eye and skin irritation, shortness of breath, ataxia, and other health problems. Additionally, contact urticaria, skin eruptions, or toxic encephalopathy in youngsters are among the negative consequences. Additionally, since some of the synthetic pesticides used to control vectors are not naturally degradable, they are permanently harming the ecosystem. These issues emphasise the requirement for the creation of efficient and secure non-DEET substitutes.

Due to the aforementioned issue, DEET replacement efforts have been extensive. Eucalyptus oil, lemongrass oil, and neem oil are known to be excellent at keeping mosquitoes away, but they are not as effective as DEET.

Due to the aforementioned factors, there are issues with the practical application of mosquito repellents that contain ingredients like eucalyptus oil, eucalyptus citrodora oil, lemongrass oil, neem oil, sage oil, lavender oil, tea tree oil, geranium oil, and rosemary oil, soyabean oil, wheat germ oil, bhutika oil , clove essential oil, devadaru oil, cedarwood oil or thyme oil or combination thereof. As a result, in-depth investigations and research are conducted to create brand-new insect repellents created from naturally derived oils.

OBJECTS OF THE INVENTION
It is an object of the present invention to provide an insect (mosquito) repellent composition comprising naturally derived oils being harmless to a human body.

It is another object of the present invention to provide a mosquito repellent composition having excellent mosquito repellent effect.

Yet another object of the present invention is to provide insect repellent composition having enhanced repellent activity of the naturally derived oils as compared to synthetic oils.

Yet another object of the present invention is to provide insect repellent composition comprising naturally derived eucalyptus citrodora oil.

Still another object of the present invention is to provide insect repellent composition comprising naturally derived eucalyptus oil and at least one another naturally derived oil selected from eucalyptus citrodora oil, lemongrass oil, neem oil, sage oil, lavender oil, tea tree oil, geranium oil, and rosemary oil, soyabean oil, wheat germ oil, bhutika oil , clove essential oil, devadaru oil, cedarwood oil or thyme oil or combination thereof.

SUMMARY OF THE INVENTION
According to an aspect of the present invention there is provided an insect repellent composition comprising at least one naturally derived oils selected from naturally derived eucalyptus oil, eucalyptus citrodora oil, lemongrass oil, neem oil, sage oil, lavender oil, tea tree oil, geranium oil, and rosemary oil, soyabean oil, wheat germ oil, bhutika oil , clove essential oil, devadaru Oil, cedarwood oil or thyme oil or combination thereof and at least one excipient.

According to an aspect of the present invention there is provided an insect repellent composition comprising:
i. at least one naturally derived oil; and
ii. at least one excipient.

According to another aspect of the present invention there is provided an insect repellent composition comprising:
i. naturally derived Eucalyptus Citrodora oil; and
ii. at least one excipient.

According to another aspect of the present invention there is provided an insect repellent composition comprising:

i. naturally derived Eucalyptus Citrodora oil;
ii. lemongrass oil; and
iii. at least one excipient.

According to another aspect of the present invention there is provided an insect repellent composition comprising:

i. naturally derived Eucalyptus Citrodora oil;
ii. lemongrass oil;
iii. neem oil; and
iv. at least one excipient.

As a result of extensive study and research to overcome the drawbacks seen in the use of commercially available mosquito repellent based on DEET and DEBA, the present inventors have surprisingly developed a mosquito repellent composition comprising of naturally derived oils with enhanced mosquito repellent activity when compared to the synthetic oils-based mosquito repellent. The present invention's mosquito repellent composition has improved mosquito repellent activity when compared to DEET and DEBA-based mosquito repellents and other herbal ingredients based mosquito repellents.

DETAILED DESCRIPTION OF THE INVENTION
For the purposes of the following detailed description, it is to be understood that the invention may assume various alternative variations and step sequences, except where expressly specified to the contrary.

Thus, before describing the present invention in detail, it is to be understood that this invention is not limited to particularly exemplified systems or process parameters that may of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments of the invention only and is not intended to limit the scope of the invention in any manner. The use of examples anywhere in this specification including examples of any terms discussed herein is illustrative only, and in no way limits the scope and meaning of the invention or of any exemplified term. Likewise, the invention is not limited to various embodiments given in this specification. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In the case of conflict, the present document, including definitions will control.

It should be noted that, as used in this specification, the singular forms “a,” “an” and “the” include plural referents unless the content clearly dictates otherwise. The terms “preferred” and “preferably” refer to embodiments of the invention that may afford certain benefits, under certain circumstances.

As used herein, the terms “comprising” “including,” “having,” “containing,” “involving,” and the like are to be understood to be open-ended, i.e., to mean including but not limited to. It should be emphasized that the term “comprises/comprising” when used in this specification is taken to specify the presence of stated features, steps or components but does not preclude the presence or addition of one or more other features, steps, components or groups thereof.

Accordingly, it should be apparent to those skilled in the art that the following description of exemplary embodiments of the present invention are provided for illustration purpose only and not for the purpose of limiting the scope of the invention as defined by the appended claims and their equivalents.

The present invention relates to an insect repellent composition comprising an insect repellent composition comprising naturally derived oils. The present invention more particularly relates to mosquito repellent composition comprising at least one of the naturally derived oils selected from naturally derived eucalyptus oil, Eucalyptus Citrodora oil, lemongrass oil, neem oil, sage oil, Lavender oil, Tea Tree oil, geranium oil, and rosemary oil, soyabean oil, Wheat germ oil, Bhutika Oil , Clove essential oil, Devadaru Oil, cedarwood oil or thyme oil or combination thereof and at least one excipient, which possesses enhanced, mosquito repellent activity.

The term “repellent” as it relates to mosquito, includes killing of the insect.

The term “naturally derived” relates to ingredients that have been taken (or “derived”) from nature for e.g., plants.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. The terminology used in the description of the disclosure herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure.

In one embodiment of the present invention there is provided an insect repellent composition comprising at least one naturally derived oils selected from eucalyptus oil, Eucalyptus Citrodora oil, lemongrass oil, neem oil, sage oil, Lavender oil, Tea Tree oil, geranium oil, and rosemary oil, soyabean oil, Wheat germ oil, Bhutika Oil , Clove essential oil, Devadaru Oil, cedarwood oil or thyme oil or combination thereof and at least one excipient.

In an embodiment of the present invention there is provided an insect repellent composition comprising:
iii. at least one naturally derived oil; and
iv. at least one excipient.

In an embodiment, the naturally derived oil includes but are not limited to eucalyptus oil, eucalyptus citrodora oil, lemongrass oil, neem oil, sage oil, lavender oil, tea tree oil, geranium oil, and rosemary oil, soyabean oil, wheat germ oil, bhutika oil , clove essential oil, devadaru oil, cedarwood oil or thyme oil or combination thereof.

In another embodiment, the present disclosure provides an insect repellent composition comprising:
i. at least one naturally derived oil selected from eucalyptus oil, eucalyptus citrodora oil, lemongrass oil, neem oil, sage oil, lavender oil, tea tree oil, geranium oil, and rosemary oil, soyabean oil, wheat germ oil, bhutika oil, clove essential oil, devadaru oil, cedarwood oil or thyme oil or combination thereof; and
ii. at least one excipient

In another embodiment of the present invention there is provided an insect repellent composition comprising:
i. naturally derived eucalyptus oil; and
ii. at least one excipient.

In another embodiment of the present invention there is provided an insect repellent composition comprising:

i. naturally derived eucalyptus oil;
ii. lemongrass oil; and
iii. at least one excipient.

In an embodiment, lemongrass oil is a naturally derived lemongrass oil.

In yet another embodiment of the present invention there is provided an insect repellent composition comprising:

i. naturally derived eucalyptus oil;
ii. lemongrass oil;
iii. neem oil; and
iv. at least one excipient.

In an embodiment, lemongrass and neem oil are naturally derived oils.

In an embodiment, the concentration of naturally derived oils is in the range from about 0.01% w/v to about 50% w/v of the total weight of the composition.

In an embodiment of the present invention the concentration of the naturally derived Eucalyptus oil (active component p-menthane-3,8-diol, or PMD) is in the range from 0.01 to 50% w/v of the total composition.

In another embodiment, the concentration of Eucalyptus oil is in the range of 1% w/v to 25% w/v of the total composition.

In another embodiment, the concentration of Eucalyptus oil is in the range of 5% w/v to 20% w/v of the total composition.

In an embodiment of the present invention eucalyptus oil is the naturally derived Eucalyptus citriodora oil.

In an embodiment of the present invention, the concentration of Lemongrass oil is in the range from 0.01 to 30% w/v of the total composition.

In another embodiment, the concentration of Lemongrass oil is in the range from 1 to 20% w/v of the total composition.

In another embodiment, the concentration of Lemongrass oil is in the range from 2% to 15% w/v of the total composition.

In another embodiment, the concentration of Lemongrass oil is in the range from 3 to 10 % w/v of the total composition.

In an embodiment of the present invention, the concentration of neem oil neem oil is in the range from 0.01 to 50% w/v of the total composition.

In another embodiment, the concentration of neem oil is in the range from 1 % to 40 % w/v of the total composition of the total composition.

In another embodiment, the concentration of neem oil is in the range from 5 % to 30 % w/v of the total composition of the total composition.

In another embodiment, the concentration of neem oil is in the range from 10 % to 20 % w/v of the total composition of the total composition.

In another embodiment of the present invention, the concentration of Thyme oil is in the range from 0.01 to 30% w/v of the total composition.

In another embodiment of the present invention, the concentration of excipient is in the range from 0.01 to 99 % w/v of the total composition.

In an embodiment the excipient comprises solvents, surfactant, fragrance, antioxidants, preservatives, perfume, or a combination thereof.

In an embodiment of the present invention solvents includes but are not limited to hydrocarbon solvents, Methanol, Ethanol, Isopropanol (IPA), Butanol, Pentanol, or Hexanol or a combination thereof.

In another embodiment of the present invention, hydrocarbon solvents are selected from dearomatized hydrocarbon fluid. Some examples of hydrocarbon solvents are benzene, kerosene and xylene. Few of the examples of hydrocarbon solvent are benzene, Heptane, Hexane, Isopar M, Kerosene, Ligroin, Limonene, Mesitylene, Methylcyclohexane, white spirit, xylene etc.

In an embodiment, the concentration of solvent is in the range from 10% to 70% w/v of the total composition.

In another embodiment, the concentration of solvent is in the range from 20% to 60% w/v of the total composition.

In another embodiment, the concentration of solvent is in the range from 30% to 60% w/v of the total composition.

In an embodiment of the present invention, surfactants are selected from Tween 20, Anionic Surfactants, Nonionic Surfactants, Cationic Surfactants and zwitterionic surfactant.

In an embodiment, anionic surfactant include but are not limited to ammonium lauryl sulfate, sodium lauryl sulfate (sodium dodecyl sulfate, SLS, or SDS), alkyl-ether sulfates sodium laureth sulfate (sodium lauryl ether sulfate or SLES), sodium myreth sulfate, Docusate (dioctyl sodium sulfosuccinate) Perfluorooctanesulfonate (PFOS), Perfluorobutanesulfonate,Alkyl-aryl ether phosphates, Alkyl ether phosphates, Carboxylates, sodium stearate, sodium lauroyl sarcosinate, carboxylate-based fluorosurfactants such as perfluorononanoate, perfluorooctanoate (PFOA or PFO) or a combination thereof.

In an embodiment cationic surfactants include but are not limited to quaternary ammonium salts: cetrimonium bromide (CTAB), cetylpyridinium chloride (CPC), benzalkonium chloride (BAC), benzethonium chloride (BZT), dimethyldioctadecylammonium chloride, dioctadecyldimethylammonium bromide (DODAB) or combinations thereof.

In an embodiment zwitterionic surfactants include but are not limited to phospholipids phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, sphingomyelins, Lauryl dimethylamine oxide, myristamine oxide or combination thereof.

In an embodiment, non-ionic surfactants Ethoxylates, Fatty alcohol ethoxylates, Narrow-range ethoxylate, Octaethylene glycol monododecyl ether, Pentaethylene glycol monododecyl ether.

Other surfactant that may be employed in the formulation includes Fatty acid ethoxylates, Fatty acid ethoxylates, Ethoxylated amines and/or fatty acid amides, Polyethoxylated tallow amine, Cocamide monoethanolamine, Cocamide diethanolamine, Terminally blocked ethoxylates Poloxamers, Fatty acid esters of polyhydroxy compounds, Fatty acid esters of glycerol, Fatty acid esters of sorbitol, Spans, Tweens, Polyglycosides, alkylamidopropylamine N-oxide (APAO), alkyldimethylamine N-oxide (AO), alkylbetaine (Bt), alkylamidopropylbetaine (APB). Cocamidopropyl betaine, cocoamphoacetate, cocoamphodiacetate.

In an embodiment, the concentration of surfactant is in the range from 0.01% w/v to 10% w/v of the total composition.

In an embodiment, the concentration of surfactant is in the range from 1% w/v to 5% w/v of the total composition.

In an embodiment, the insect repellent composition is formulated in the form of spray, semisolid, liquid vaporiser, aerosol, cream, lotion, semisolid, emulsion, flowable, invert emulsion, solid, suspension composition etc.

In an embodiment, the aerosol or spray formulation comprises propellants selected from chlorofluorocarbons, fluorocarbons (trichloromonofluoromethane, dichlorodifluoromethane), hydrocarbons (propane, butane, isobutane), hydrochlorofluorocarbons, hydrofluorocarbons, inert gases (nitrogen, NO2, CO2), compressed gases or a combination thereof.

The insect repellent composition of the present invention provides enhanced, mosquito repellent activity of the naturally derived oils as compared to synthetic oils.

The following examples illustrate the disclosure, but by no means intend to limit the scope of the invention.

In an embodiment, the present invention provides a process for preparation of insect repellent composition. To prepare the composition solvents are first mixed in a vessel, slowly add antioxidants/preservatives to the vessel containing the solvents under stirring, add perfume under stirring and mix. Process the naturally derived oils and add the oils in the vessel containing solvents, antioxidants and perfume. Stop stirring & filter above mixture to obtain the final insect repellent composition.

In another embodiment, the present invention provides a process for preparation of insect repellent composition. To prepare the composition solvents are first mixed in a vessel, slowly add antioxidants/preservatives to the vessel containing the solvents under stirring (100-200 RPM), add perfume under stirring and mix for 5 to 10 minutes. Melt the eucalyptus citriodora oil at 80-90? to get a clear solution and then add melted eucalyptus citriodora oil in the vessel containing solvents, antioxidants and perfume. Add lemon grass oil under stirring and mix the solution of 30-45 minutes to obtain a clear solution. Stop stirring and filter above mixture through cotton filter or sparkling filter to obtain the insect repellent composition.

EXAMPLES
The present invention will now be explained in detail by reference to the following formulation examples and a test example, which should not be construed as limiting the scope of the present invention.

Below mentioned formulations have been prepared by the process as described herein. Solvent(s) were mixed in a vessel, antioxidants/preservatives were slowly added to the vessel containing the solvents under stirring (100-200 RPM), perfume was added under stirring and was mixed for 5 to 10 minutes. Naturally derived oils were added in the vessel containing solvents, antioxidants and perfume under stirring. the above mixture was then filtered to obtain final composition.

EXAMPLE 1: MOSQUITO REPELLENT ROLL ON

Table 1
Sr. No. Raw materials % W/V
1 Isopropanol (IPA) 55-65
2 Naturally derived Lemon Grass Oil 1-30
3 Naturally derived Eucalyptus Citriodora Oil 0.01-50
4 Surfactant 0.01-10
5 Fragrance 0-5
6 Water purified Q.S.
Total 100.00

EXAMPLE 2: MOSQUITO REPELLENT BODY SPRAY

Table 2
Sr. No. Raw materials % W/V
1 Isopropanol (IPA) 55-65
2 Naturally derived Lemon Grass Oil 1-30
3 Naturally derived Eucalyptus Citriodora Oil 0.01-50
4 Surfactant 0.01-10
5 Fragrance 0-5
6 Water purified Q.S.
Total 100.00

EXAMPLE 3: MOSQUITO REPELLENT ROOM SPRAY

Table 3
Sr. No. Raw materials % W/V
1 Isopropanol (IPA) 55-65
2 Naturally derived Lemon Grass Oil 1-30
3 Naturally derived Eucalyptus Citriodora Oil 0.01-50
4 Surfactant 0.01-10
5 Fragrance 0-5
6 Water purified Q.S.
Total 100.00

EXAMPLE 4: MOSQUITO REPELLENT LIQUID VAPORIZER

Table 4
Sr. No. Ingredient FORMULATION 1
% W/V
1 Hydrocarbon Solvent 1 10-70
2 Hydrocarbon Solvent 2 10-70
3 Antioxidant 0.01-10
4 Naturally derived Eucalyptus citriodora oil 0.1-10
5 Lemon grass oil 0.1-10
6 Perfume 0.01
Total 100.00

EXAMPLE 5: MOSQUITO REPELLENT WITH AZADIRACHTIN

Table 5
Sr. No. Raw materials % W/V
1 Butanol 55-65
2 Naturally derived Neem Oil 1-30
3 Surfactant 0.01-10
4 Fragrance 0-5
5 Water purified Q.S.
Total 100.00

EXAMPLE 6: MOSQUITO REPELLENT SPRAY

Table 6
Sr. No. Raw materials % W/V
1 Isopropanol (IPA) 55-65
2 Naturally derived Neem oil 1-30
3 Naturally derived Eucalyptus Citriodora Oil 0.01-50
4 Surfactant 0.01-10
5 Fragrance 0-5
6 Water purified Q.S.
Total 100.00

EXAMPLE 7: MOSQUITO REPELLENT SPRAY

Table 7
Sr. No. Raw materials % W/V
1 Ethanol 55-65
2 Naturally derived Neem oil 1-50
3 Naturally derived Lemon Grass Oil 1-30
4 Surfactant 0.01-10
5 Fragrance 0-5
6 Water purified Q.S.
Total 100.00

EXAMPLE 8: MOSQUITO REPELLENT SPRAY

Table 8
Sr. No. Raw materials % W/V
1 Ethanol 55-65
2 Naturally derived Neem oil 0-50
3 Naturally derived Thyme Oil 1-30
4 Surfactant 0.01-10
5 Fragrance 0-5
6 Water purified Q.S.
Total 100.00

EXAMPLE 9: MOSQUITO REPELLENT SPRAY

Table 9
Sr. No. Raw materials % W/V
1 Isopropanol (IPA) 61.5
2 Naturally derived Lemon Grass Oil 3
3 Naturally derived Eucalyptus Citriodora Oil 20
4 Surfactant 2.5
5 Fragrance 1
6 Water purified QS
Total 100.00

EXAMPLE 10 : EFFICAY OF NATURAL PMD Vs. SYNTHETIC PMD

The below experimental data demonstrates the enhanced repellent effect of natural PMD envisaged according to the present invention as compared to synthetic PMD.

Table 10
NO EXAMPLE REPELLENCE DATA % KNOCKDOWN of Mosquito
1 Natural PMD 80.66
2 Natural PMD 85.66
3 Synthetic PMD 63.88
4 Synthetic PMD 69.90
5 Synthetic PMD 54.56

Conclusion: Natural PMD has enhanced repellent effect as compared to synthetic PMD

EXAMPLE 11: Comparison of commercially available formulation (with other herbal ingredients) with formulation comprising natural Eucalyptus oil of the present invention.

Table 11
Sr. No. FORMULATION 1
FORMULATUON 2
FORMULATION 3
WITH NATURAL PMD
1 Purified Water CCTG Isopropanol (IPA)
2 Cold Pressed Soybean Oil Lemon grass oil Naturally Lemon Grass Oil
3 Cold Pressed Castor Oil Rose gerenium oil Naturally derived Eucalyptus Citriodora Oil (PMD)
4 Cedar Essential Oil lemon Eucalyptus oil Tween 20
5 Citronella Essential Oil Vit. E oil Fragrance
6 Lemongrass Essential Oil Purified Water
7 Peppermint Essential Oil
8 Rosemary Essential Oil
9 Synthetic Eucalyptus Oil

RESULTS: REPELLENCE EFFECT
Table 12
SR. NOS. FORMULATIONS
% KNOCKDOWN
1 FORMULATION 1
(Market sample) 31.33
2 FORMULATUON 2
(Market sample) 46.66
3 FORMULATION 3 WITH NATURAL PMD 85.66

EXAMPLE 12: COMPARISON OF FORMULATION COMPRISING NATURAL PMD WITH DEET, DEBA, AND MARKET COMPETITIVE PRODUTS

Table 13
SR.NO FORMULATIONS KT 50 KT 95 KNOWKDOWN %
1 Herbal 18% (Eucalyptus citriodora oil + lemon grass oil) 33.01 429.07 35.33
2 Herbal 9% (Eucalyptus citriodora oil + lemon grass oil) 457.47 -
3 DEET 20% 37.32 495.33 62.66
4 DEBA 20% 27.75 275.00 77.33
5 BUG OFF 36.56 476.02 66.66
6 Synthetic PMD 30% 26.20 207.71 80.66
7 Natural PMD 20% 26.421 230.86 85.66

EXAMPLE 13: EFFECT OF DIFFERENT ALCOHOLIC SOLVENT ON THE REPELLENCE EFFECT

Table 14
Sr no. Ingredients Isopropanol (IPA) Methanol Ethanol Butanol Pentanol Hexanol
FORM. 1 FORM. 2 FORM. 3 FORM. 4 FORM. 5 FORM. 6
% w/v % w/v % w/v % w/v % w/v % w/v
1 Alcohol 55-65 55-65 55-65% 55-65% 55-65% 55-65%
2 Lemon Grass Oil 0-30 0-30 0-30 0-30 0-30 0-30
3 Eucalyptus Citriodora Oil 0.01-50 0.01-50 0.01-50 0.01-50 0.01-50 0.01-50
4 Tween 20 0.01-10 0.01-10 0.01-10 0.01-10 0.01-10 0.01-10
5 Fragrance 0-5 0-5 0-5 0-5 0-5 0-5
6 Water purified q.s. q.s. q.s. q.s. q.s. q.s.

RESULTS: % REPELLENCE TESTING

Table 15
Sr.no. Formulations % Repellence
1 Formulation 1 85.66
2 Formulation 2 62.00
3 Formulation 3 57.85
4 Formulation 4 71.26
5 Formulation 5 67.10
6 Formulation 6 58.62

It was thus found that the presence of isopropanol significantly enhanced the mosquito repellent effect of naturally derived essential oil especially of naturally derived Eucalyptus oil.

The foregoing description of the specific embodiments reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and/or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments in this disclosure have been described in terms of different embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the embodiments as described herein.

Throughout this specification, the term ‘combinations thereof’ or ‘any combination thereof’ or ‘any combinations thereof’ are used interchangeably and are intended to have the same meaning, as regularly known in the field of patents disclosures.

As regards the embodiments characterized in this specification, it is intended that each embodiment be read independently as well as in combination with another embodiment. For example, in case of some embodiments 1 reciting 3 alternatives A, B and C, some embodiments 2 reciting 3 alternatives D, E and F and some embodiments 3 reciting 3 alternatives G, H and I, it is to be understood that the specification unambiguously discloses embodiments corresponding to combinations A, D, G; A, D, H; A, D, I; A, E, G; A, E, H; A, E, I; A, F, G; A, F, H; A, F, I; B, D, G; B, D, H; B, D, I; B, E, G; B, E, H; B, E, I; B, F, G; B, F, H; B, F, I; C, D, G; C, D, H; C, D, I; C, E, G; C, E, H; C, E, I; C, F, G; C, F, H; C, F, I, unless specifically mentioned otherwise.

Any discussion of documents, acts, materials, devices, articles and the like that has been included in this specification is solely for the purpose of providing a context for the disclosure. It is not to be taken as an admission that any or all of these matters form a part of the prior art base or were common general knowledge in the field relevant to the disclosure as it existed anywhere before the priority date of this application.
,CLAIMS:
1. An insect repellent composition comprising:
a. at least one naturally derived oil selected from eucalyptus oil, eucalyptus citrodora oil, lemongrass oil, neem oil, sage oil, lavender oil, tea tree oil, geranium oil, rosemary oil, soyabean oil, wheat germ oil, bhutika oil, clove essential oil, devadaru oil, cedarwood oil, thyme oil or a combination thereof; and
b. at least one excipient.

2. The composition as claimed in claim 1, wherein the naturally derived oils are employed in a concentration in the range from about 0.01% w/v to about 50% w/v of the total weight of the composition.

3. The composition as claimed in claim 1, wherein the excipient is selected from solvents, surfactant, fragrance, antioxidant, perfume, or a combination thereof.

4. The composition as claimed in claim 3, wherein the solvents are selected from hydrocarbon solvents, methanol, ethanol, isopropanol (IPA), butanol, pentanol, or hexanol or a combination thereof.

5. The composition as claimed in claim 4, wherein the solvents are employed in a concentration in the range from about 30% to 60% w/v of the total composition.

6. The composition as claimed in claim 3, wherein surfactants are selected from tween 20, anionic surfactants, nonionic surfactants, cationic surfactants and zwitterionic surfactant.

7. The composition as claimed in claim 6, wherein the surfactants are employed in a concentration in the range from about 0.01% w/v to about 10% w/v of the total composition.

8. The composition as claimed in claim 1, wherein the insect repellent composition is formulated in the form of spray, semisolid, liquid vaporiser, aerosol, cream, lotion, semisolid, emulsion, flowable, invert emulsion, solid, suspension composition.

9. The composition as claimed in claim 1, wherein the naturally derived oils have a higher insect repellent activity as compared to synthetic oils.

Documents

Application Documents

# Name Date
1 202321014870-STATEMENT OF UNDERTAKING (FORM 3) [06-03-2023(online)].pdf 2023-03-06
2 202321014870-PROVISIONAL SPECIFICATION [06-03-2023(online)].pdf 2023-03-06
3 202321014870-POWER OF AUTHORITY [06-03-2023(online)].pdf 2023-03-06
4 202321014870-FORM 1 [06-03-2023(online)].pdf 2023-03-06
5 202321014870-Proof of Right [08-05-2023(online)].pdf 2023-05-08
6 202321014870-ORIGINAL UR 6(1A) ASSIGNMENT-230523.pdf 2023-05-25
7 202321014870-REQUEST FOR CERTIFIED COPY [28-07-2023(online)].pdf 2023-07-28
8 202321014870-CORRESPONDENCE(IPO)-(CERTIFIED COPY)-(08-08-2023).pdf 2023-08-08
9 202321014870-ORIGINAL U-R 6(1A) ASSIGNMENT-190623.pdf 2023-09-15
10 202321014870-ENDORSEMENT BY INVENTORS [05-03-2024(online)].pdf 2024-03-05
11 202321014870-COMPLETE SPECIFICATION [05-03-2024(online)].pdf 2024-03-05
12 202321014870-FORM 18 [12-03-2024(online)].pdf 2024-03-12