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"Muscarinic Receptor Antagonists"

Abstract: This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the prepration of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

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Patent Information

Application #
Filing Date
14 March 2007
Publication Number
33/2007
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application

Applicants

RANBAXY LABORATORIES LIMITED
12TH FLOOR, DEVIKA TOWER,6, NEHRU PLACE, NEW DELHI-110019

Inventors

1. MOHAMMAD SALMAN
PLOT NO.20, SECTOR-18, UDYOG VIHAR INDUSTRIAL AREA, GURGAON-122 001,HARYANA,INDIA
2. PAKALA KUMARA SAVITHRU SARMA
PLOT NO.20, SECTOR-18, UDYOG VIHAR INDUSTRIAL AREA, GURGAON-122 001,HARYANA,INDIA
3. SANKARANARAYANAN DHARMARAJAN
PLOT NO.20, SECTOR-18, UDYOG VIHAR INDUSTRIAL AREA, GURGAON-122 001,HARYANA,INDIA
4. ANITA CHUGH
PLOT NO.20, SECTOR-18, UDYOG VIHAR INDUSTRIAL AREA, GURGAON-122 001,HARYANA,INDIA
5. SUMAN GUPTA
PLOT NO.20, SECTOR-18, UDYOG VIHAR INDUSTRIAL AREA, GURGAON-122 001,HARYANA,INDIA

Specification

Field of the Invention This present invention generally relates to muscarinic receptor antagonists, which are suitable, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Background of the Invention Muscarinic receptors as members of the G Protein Coupled Receptors (GPCRs) are composed of a family of 5 receptor sub-types (Mi, M2, M3, M4 and M5) and are activated by the neurotransmitter acetylcholine. These receptors are widely distributed on multiple organs and tissues and are critical to the maintenance of central and peripheral cholinergic neurotransmission. The regional distribution of these receptor sub-types in the brain and other organs has been documented (for example, the M] subtype is located primarily in neuronal tissues such as cereberal cortex and autonomic ganglia, the Ma subtype is present mainly in the heart where it mediates cholinergically induced bradycardia, and the Mj subtype is located predominantly on smooth muscle and salivary glands (Nature, 323, p.411 (1986); Science, 237, p.527 (1987)). A review in Current Opinions in Chemical Biology, 3, p. 426 (1999), as well as in Trends in Pharmacological Sciences, 22, p. 409 (2001) by Eglen et. al., describes the biological potentials of modulating muscarinic receptor subtypes by ligands in different disease conditions, such as Alzheimer's Disease, pain, urinary disease condition, chronic obstructive pulmonary disease, and the like. A review in J. Med. Chem., 43, p. 4333 (2000), by Felder et. al. describes therapeutic opportunities for muscarinic receptors in the central nervous system and elaborates on muscarinic receptor structure and function, pharmacology and their therapeutic uses. The pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists are presented in a review in Molecules, 6, p. 142 (2001). Birdsall et al. in Trends in Pharmacological Sciences, 22, p. 215 (2001) have also summarized the recent developments on the role of different muscarinic receptor subtypes using different muscarinic receptor of knock out mice. Muscarinic agonists such as muscarine and pilocarpine and antagonists such as atropine have been known for over a century, but little progress has been made in the discovery of receptor subtype-selective compounds, making it difficult to assign specific functions to the individual receptors. Although classical muscarinic antagonists such as atropine are potent bronchodilators, their clinical utility is limited due to high incidence of both peripheral and central adverse effects such as tachycardia, blurred vision, dryness of mouth, constipation, dementia, etc.. Subsequent development of the quarterly derivatives of atropine such as ipratropium bromide are better tolerated than parenterally administered options, but most of these are not ideal anti-cholinergic bronchodilators, due to lack of selectivity for muscarinic receptor sub-types, resulting in doselimiting side-effects such as thirst, nausea, mydriasis and those associated with the heart such as tachycardia mediated by the Ma receptor. Annual Review of Pharmacological ToxicoL, 41, p. 691 (2001), describes the pharmacology of the lower urinary tract infections. Although anti-muscarinic agents such as oxybutynin and tolterodine that act non-selectively on muscarinic receptors have been used for many years to treat bladder hyperactivity, the clinical effectiveness of these agents has been limited due to the side effects such as dry mouth, blurred vision and constipation. Tolterodine is considered to be generally better tolerated than oxybutynin. (Steers et. al., in Curr. Opin. Invest. Drugs, 2, 268; Chappie et. al., in Urology, 55, 33; Steers et al., Adult and Pediatric Urology, ed. Gillenwatteret al., pp 1220-1325, St. Louis, MO; Mosby. 3rd edition (1996)). There remains a need for development of new highly selective muscarinic antagonists which can interact with distinct subtypes, thus avoiding the occurrence of adverse effects. WO 04/005252 discloses azabicyclo derivatives described as muscarinic receptor antagonists. WO 04/004629, WO 04/052857, WO 04/067510, WO 04/014853, WO 04/014363 discloses 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives described as useful muscarinic receptor antagonists. WO 04/056811 discloses flaxavate derivatives as muscarinic receptor antagonists. WO 04/056810 discloses xanthene derivatives as muscarinic receptor antagonists. WO 04/056767 discloses l-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists. WO 04/089363, WO 04/089898, WO 04/069835, WO 04/089900 and WO 04/089364 discloses substituted azabicyclohexane derivatives as muscarinic receptor antagonists. Compounds having antagonistic activity against muscarinic receptors have been described in Japanese patent application Laid Open Number 92921/1994 and 135958/1994; WO 93/16048; U.S. Patent No. 3,176,019; GB 940,540; EP 0325 571; WO 98/29402; EP 0801067; EP 0388054; WO 9109013; U.S. Patent No. 5,281,601. Also, U.S. Patent Nos. 6,174,900, 6,130,232 and 5,948,792; WO 97/45414 are related to 1,4-disubstituted piperidine derivatives; WO 98/05641 describes fluorinated, 1,4-disubstitued piperidine derivatives; WO 93/16018 and WO96/33973 are other references of interest. US Patent No. 5,397,800 discloses l-azabicyclo[2.2.1]heptanes. US Patent No.5, 001,160 describes l-aryl-l-hydroxy-l-substituted-3-(4-substituted-l-piperazinyl)-2- propanones. WO 01/42213 describes 2-biphenyl-4-piperidinyl ureas. WO 01/42212 describes carbamate derivatives. WO 01/90081 describes amino alkyl lactam. WO 02/53564 describes novel quinuclidine derivatives. WO 02/00652 describes carbamates derived from arylalkyl amines. WO 02/06241 describes l,2,3,5-tetrahydrobenzo(c)azepin-4-one derivatives. U.S. application No. 20030105071 describes thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonic receptors and transporters, and method of use thereof. J. Med. Chem., 44, p. 984 (2002), describes cyclohexylmethylpiperidinyltriphenylpropioamide derivatives as selective Ma antagonist discriminating against the other receptor subtypes. J. Med. Chem., 36, p. 610 (1993), describes the synthesis and antimuscarinic activity of some l-cycloalkyl-l-hydroxy-l-phenyl-3-(4-substituted piperazinyl)-2-propanones and related compounds. J. Med. Chem., 34> P-3065 (1991), describes analogues of oxybutynin, synthesis and antimuscarinic activity of some substituted 7-amino-l-hydroxy-5-heptyn-2-ones and related compounds. Summary of the Invention In one aspect, there are provided muscarinic receptor antagonists, which can be useful as safe and effective therapeutic or prophylactic agents for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems. Also provided are processes for synthesizing such compounds. In another aspect, pharmaceutical compositions containing such compounds are provided together with acceptable carriers, excipients or diluents which can be useful for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems. The enantiomers, diastereomers, N-oxides, polymorphs, pharmaceutically acceptable salts and pharmaceutically acceptable solvates of these compounds as well as metabolites having the same type of activity are also provided, as well as pharmaceutical compositions comprising the compounds, their metabolites, enantiomers, diastereomers, N-oxides, polymorphs, solvates or pharmaceutically acceptable salts thereof, in combination with a pharmaceutically acceptable carrier and optionally included excipients. Other aspects will be set forth in the description which follows, and in part will be apparent from the description or may be learnt by the practice of the invention. In accordance with one aspect, there are provided compounds having the structure of Formula I: and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, esters, enantiomers, diastereomers, N-oxides, polymorphs, metabolites, wherein represents an optional double bond; X can be alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclyl alkyl, or heteroarylalkyl. RI can be hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, aryloxy; -(CH2)o-2- heterocyclylalkyl, or -(CH2)o-2-heteroarylalkyl. R2 can be -(CH2)o-2-heteroaryl, -(CH2)o-2-heterocyclyl, or -(CH2)o-2-aryl, or RI and R2 may together combine to form a (un)saturated monocyclic or bicyclic ring system containing 0-4 heteroatoms (O, N or S) wherein the ring can be optionally substituted with one or more of alkyl; alkenyl; alkynyl; cycloalkyl; alkaryl; alkoxy; aryloxy; halogen (F, Cl, Br, I); heterocyclyl; heteroaryl; heterocyclylalkyl; heteroarylalkyl; carboxy; nitro; cyano; -C(=O)NRxRy (wherein Rx and Ry can be hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, hydroxy, alkoxy, aryloxy, -(CH2)o-2-heteroaryl, or - (CH2)o-2-heterocyclyl); -NRxRy (wherein Rx and Ry are as defined above), or -O-C(=O)NRxRy (wherein Rx and Ry are as defined above). G can be -OR (wherein R represents hydrogen or unsubstituted lower (Ci-Ce) alkyl); -NOR (wherein R is the same as defined above); -NHYR' (wherein R' is hydrogen, alkyl or aryl and Y is -C(=0), -SO or -SO2); or oxygen (provided that RI and R2 together does not form a pyrrolidine, 4- hydroxy piperidine, 4-pyrrolidinyl piperidine, piperazine or azabicyclo [3.1.0] hexane ring). The following definitions apply to terms as used herein. The term "alkyl," unless otherwise specified, refers to a monoradical branched or unbranched saturated hydrocarbon chain having from 1 to 20 carbon atoms. This term is exemplified by groups such as methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, t-butyl, nhexyl, n-decyl, tetradecyl, and the like. Alkyl may further be substituted with one or more substituents such as alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkenyl, acyl, acylamino, acyloxy, alkoxycarbonylamino, azido, cyano, halogen, hydroxy, oxo, thiocarbonyl, carboxy, carboxyalkyl, arylthio, thiol, alkylthio, aryloxy, aminosulfonyl, aminocarbonylamino, -NRxRy, -C(=O)NRxRy, -0- C(=O)NRxRy (wherein Rx and Ry are the same as defined earlier), nitro, -S(O)nR3 wherein Ra is alkyl, aryl or heteroaryl. Unless otherwise constrained by the definition, all substituents may be further substituted by 1-3 substituents chosen from alkyl, carboxy, -NRxRy, -C(=0)NRxRy, -OC(= O)NRxRy (wherein Rx and Ry are the same as defined earlier), hydroxy, alkoxy, halogen, CFs, cyano, and -S(O)nR3, where Ra is the same as defined earlier and n is 0, 1 or 2. Alkyl groups may also be interrupted by 1-5 atoms of groups independently chosen from oxygen, sulfur and -NRa-, where Ra is chosen from hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl. Unless otherwise constrained by the definition, all substituents may be further substituted by 1-3 substituents chosen from alkyl, carboxy, -NRxRy, -C(=O)NRxRy, -O-C(=O)NRxRy (wherein Rx and Ry are the same as defined earlier), hydroxy, alkoxy, halogen, CFs, cyano, and -S(O)nR3 where n and RS are the same as defined earlier. The term "alkenyl," unless otherwise specified, refers to a monoradical of a branched or unbranched unsaturated hydrocarbon group preferably having from 2 to 20 carbon atoms with cis or trans geometry. Particular alkenyl groups include ethenyl or vinyl, 1-propylene or allyl, isopropylene, bicyclo[2.2.1]heptene, and the like. In the event that alkenyl is attached to the heteroatom, the double bond cannot be alpha to the heteroatom. Alkenyl may further be substituted with one or more substituents such as alkyl, alkynyl, alkoxy, cycloalkyl, cycloalkenyl, acyl, acylamino, acyloxy, -NRxRy, -C(=O)NRxRy, -O-C(=O)NRxRy (wherein Rx and Ry are the same as defined earlier), alkoxycarbonylamino, azido, cyano, halogen, hydroxy, oxo, thiocarbonyl, carboxy, arylthio, thiol, alkylthio, aryl, alkaryl, aryloxy, heterocyclyl, heteroaryl, heterocyclyl alkyl, heteroaryl alkyl, aminosulfonyl, aminocarbonylamino, alkoxyamino, nitro, S(O)nR3 (wherein R3 is the same as defined earlier). Unless otherwise constrained by the definition, all substituents may optionally be further substituted by 1-3 substituents chosen from alkyl, carboxy, hydroxy, alkoxy, halogen, -CF3, cyano, -NRxRy, -C(=O)NRxRy, -O-C(=O)NRxRy (wherein Rx and Ry are the same as defined earlier) and -S(O)nR3, where R3 and n are the same as defined earlier. The term "alkynyl," unless otherwise specified, refers to a monoradical of an unsaturated hydrocarbon, preferably having from 2 to 20 carbon atoms. Particular alkynyl groups include, for example, ethynyl, propargyl or propynyl, and the like. In the event that alkynyl is attached to the heteroatom, the triple bond cannot be alpha to the heteroatom. Alkynyl may further be substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkoxy, cycloalkyl, cycloalkenyl, acyl, acylamino, acyloxy, alkoxycarbonylamino, azido, cyano, halogen, hydroxy, oxo, thiocarbonyl, carboxy, arylthio, thiol, alkylthio, aryl, alkaryl, aryloxy, aminosulfonyl, aminocarbonylamino, nitro, heterocyclyl, heteroaryl, heterocyclylalkyl, heteroarylalkyl, -NRxRy,- C(=O)NRxRy, -OC(=O)NRxRy (wherein Rx and Ry are the same as defined earlier), -S(O)nR3 wherein R3 is the same as defined earlier. Unless otherwise constrained by the definition, all substituents may optionally be further substituted by 1-3 substituents chosen from alkyl, carboxy, carboxyalkyl, hydroxy, alkoxy, halogen, CF3, -NRxRy, -C(=O)NRxRy, -O-C(=O)NRxRy (wherein Rx and Ry are the same as defined earlier), cyano, and -S(O)nR3, where R3 and n are the same as defined earlier. The term "cycloalkyl" refers to cyclic alkyl groups of from 3 to 20 carbon atoms having a single cyclic ring or multiple condensed rings. Such cycloalkyl groups include, by way of example, single ring structures such as cyclopropyl, cyclobutyl, cyclopentyl, cyclooctyl, and the like, or multiple ring structures such as adamantanyl, and bicyclo [2.2.1]heptane, or cyclic alkyl groups to which is fused an aryl group, (for example, indane, and the like. Spiro groups are also envisioned. Cycloalkyl groups may further be substituted with one or more substituents such as alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkenyl, acyl, acylamino, acyloxy, alkoxycarbonylamino, azido, cyano, halogen, hydroxy, oxo, thiocarbonyl, carboxy, carboxyalkyl, arylthio, thiol, alkylthio, aryl, alkaryl, aryloxy, aminosulfonyl, aminocarbonylamino, -NRxRy, -C(=O)NRxRy, -O-C(=O)NRxRy (wherein Rx and Ry are the same as defined earlier), nitro, heterocyclyl, heteroaryl, heterocyclylalkyl, heteroarylalkyl, S(O)nR3 wherein R3 is same as defined earlier. Unless otherwise constrained by the definition, all substituents may optionally be further substituted by 1-3 substituents chosen from alkyl, carboxy, hydroxy, alkoxy, halogen, CF3, -NRxRy, -C(=O)NRxRy, OC(= O)NRxRy (wherein Rx and Ry are the same as defined earlier), cyano and -S(O)nR3, where R3 and n are the same as defined earlier. The term "alkoxy" denotes the group O-alkyl wherein alkyl is the same as defined above. The term "alkaryl" refers to aryl linked through alkyl (wherein alkyl is the same as defined above) portion and the said alkyl portion contains carbon atoms from 1-6 and aryl is as defined below. The term "aryl" herein refers to a carbocyclic aromatic group, (for example, phenyl, biphenyl or naphthyl ring and the like optionally substituted with 1 to 3 substituents selected from the group consisting of halogen (F, Cl, Br, I), hydroxy, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, acyl, aryloxy, cyano, nitro, -NRxRy, -C(=O)NRxRy, -O-C(=O)NRxRy (wherein Rx and Ry are the same as defined earlier), carboxy, heterocyclyl, heteroaryl, heterocyclylalkyl, heteroarylalkyl or amino carbonylamino. The aryl group may optionally be fused with heterocyclyl, cycloalkyl or heteroaryl ring system. The term "carboxy" as defined herein refers to -C(=:O)O-R4 wherein R* is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl and cycloalkyl. The term "heteroaryl," unless otherwise specified, refers to an aromatic ring structure containing 5 to 7 ring atoms, or a bicyclic aromatic group having 8 to 12 ring atoms, with one or more heteroatom(s) (N, O or S) optionally substituted with 1 to 3 substituent(s) such as halogen (F, Cl, Br, I), hydroxy, alkyl, alkenyl, alkynyl, cycloalkyl, acyl, carboxy, aryl, alkoxy, alkaryl, cyano, nitro, aminocarbonylamino, -NRxRy, -C(=O)NRxRy and -O-C(=O)NRxRy (wherein Rx and Ry are the same as defined earlier). Examples of heteroaryl groups include pyridinyl, pyridazinyl, pyrimidinyl, pyrrolyl, oxazolyl, thiazolyl, thienyl, isoxazolyl, triazinyl, furanyl, benzofuranyl, indolyl, benzothiazolyl, benzoxazolyl, and the like. The term 'heterocyclyl" unless and otherwise specified refers to a non-aromatic monocyclic or bicyclic cycloalkyl group having 5 to 10 atoms in which 1 to 3 carbon atoms in a ring are replaced by heteroatoms (O, S or N), and are optionally benzofused or fused heteroaryl of 5-6 ring members and the heterocyclyl group can be optionally substituted with substituents for example halogen (F, Cl, Br, I), hydroxy, alkyl, alkenyl, alkynyl, cycloalkyl, acyl, aryl, alkoxy, alkaryl, cyano, nitro, oxo, carboxy, aminocarbonylamino, -C(=O)NRxRy, -OC(=O)NRxRy (wherein Rx and Ry are the same as defined earlier). Examples of heterocyclyl groups include tetrahydrofuranyl, dihydrofuranyl, dihydropyridinyl, piperidinyl, piperazinyl, dihydrobenzofuryl, azabicyclohexyl, dihydroindolyl, and the like. "Heteroarylalkyl" refers to heteroaryl (wherein heteroaryl is same as defined earlier) linked through alkyl (wherein alkyl is the same as defined above) portion and the said alkyl portion contains from l-6carbon atoms. "Heterocyclylalkyl" refers to heterocyclyl (wherein heterocyclyl is same as defined earlier) linked through alkyl (wherein alkyl is the same as defined above) portion and the said alkyl portion contains from 1-6 carbon atoms. "Acyl" refers to -C(=0)R" wherein R" is selected from the group hydrogen, alkyl, cycloalkyl, aryl, alkaryl, hydroxy, alkoxy, heteroaryl, heterocyclyl, heteroarylalkyl or heterocyclylalkyl. The term "protecting groups" is used herein to refer to known moieties which have the desirable property of preventing specific chemical reaction at a site on the molecule undergoing chemical modification intended to be left unaffected by the particular chemical modification. Also the protecting group, unless otherwise specified, may be used with groups such as hydroxy, amino, carboxy and example of such groups are found in T.W. Greene and P.G.M. Wuts, "Protective Groups in Organic Synthesis", 2nd ED, John Wiley and Sons, New York, N.Y. The species of the, for example, carboxylic protecting groups, amino protecting groups or hydroxy protecting groups employed is not critical so long as the derivatised moiety/moieties is/are stable to conditions of subsequent reactions and can be removed at the appropriate point without disrupting the remainder of the molecule. In accordance with a second aspect, there is provided a method for treatment or prophylaxis of an animal or a human suffering from a disease or disorder of the respiratory, urinary and gastrointestinal systems, wherein the disease or disorder is mediated through muscarinic receptors. The method includes administration of at least one compound having the structure of Formula I. In accordance with a third aspect, there is provided a method for treatment or prophylaxis of an animal or a human suffering from a disease or disorder associated with muscarinic receptors, comprising administering to a patient in need thereof, an effective amount of a muscarinic receptor antagonist compound as described above. In accordance with a fourth aspect, there is provided a method for treatment or prophylaxis of an animal or a human suffering from a disease or disorder of the respiratory system such as bronchial asthma, chronic obstructive pulmonary disorders (COPD), pulmonary fibrosis, and the like; urinary system which induce such urinary disorders as urinary incontinence, lower urinary tract symptoms (LUTS), etc.; and gastrointestinal system such as irritable bowel syndrome, obesity, diabetes and gastrointestinal hyperkinesis with compounds as described above, wherein the disease or disorder is associated with muscarinic receptors. In accordance with a fifth aspect, there are provided processes for preparing the compounds as described above. The compounds described herein exhibit significant potency in terms of their activity, as determined by in vitro receptor binding and functional assays and in vivo experiments using anaesthetized rabbits. The compounds that were found active in vitro were tested in vivo. Some of the compounds are potent muscarinic receptor antagonists with high affinity towards MS receptors. Therefore, pharmaceutical compositions for the possible treatment for the disease or disorders associated with muscarinic receptors are provided. In addition, the compounds can be administered orally or parenterally. Detailed Description of the Invention The compounds of the present invention may be prepared by techniques well known in the art and familiar to the average synthetic organic chemist. In addition, the compounds of the present invention may be prepared, for example, by generally following the reaction scheme(s) as depicted below. (Figure Removed) The compound of Formula Vlllb, X, IXa, XI and XIa may be prepared, for example, by the reaction sequence as shown in Scheme I. The preparation comprises reacting a compound of Formula II (wherein X is the same as defined earlier) with a compound of Formula T2 (wherein T2 is lithium acetylide, cerium acetylide, sodium acetylide, potassium acetylide or lithium acetylide in complex with diethylamine), to give a compound of Formula III, which is further reacted with mercuric acetate to give a compound of Formula IV, which is hydrolysed to give a compound of Formula V, which is halogenated to give a compound of Formula VI (wherein hal is F, Cl, Br or I), which is reacted with a compound of Formula VII to give a compound of Formula VIII (wherein RI and R2 are the same as defined earlier). Path a: The compound of Formula VIII can be reacted with a compound of Formula -NH2OR to give compound of Formula X (wherein R is the same as defined earlier) Path b: The compound of Formula VIII can be reduced to give a compound of Formula IX (when R2 is (CHl>"" N _ /NP wherein P represents a protecting group such as alkaryl or acyl) Path bl: The compound of Formula IX undergoes N-derivatization (when Rl and R2 together joins to form piperazine) to give a compound of Formula IXa. Path b2: The compound of Formula IX undergoes deprotection to give a compound of Formula XI (wherein W is "' or, which undergoes reductive amination (when W is to give a compound of Formula XIa. Path c: The compound of Formula VIII can undergo reductive amination reaction to give a compound of Formula Villa. _ . , Path d: The compound of Formula VIII (when R2 is ^^ ) can undergo deprotection to give a compound of Formula VHIb. The compound of Formula II can be reacted with a compound of Formula T2 in an organic solvent (for example, tetrahydrofuran, diethyl ether or 1 ,4-dioxane) to give a compound of Formula III which can be reacted with mercuric acetate in the presence of a corresponding anhydride (for example, acetic anhydride) in an organic solvent (for example, acetic acid, propionic acid or formic acid) to give a compound of Formula IV which can be hydrolyzed in the presence of an inorganic base (for example, potassium hydroxide, sodium hydroxide or lithium hydroxide) in an organic solvent (for example, methanol, ethanol, propanol or isopropanol) to give a compound of Formula V which can be halogenated in the presence of a halogenating agent (for example, pyridine hydrobromide perbromide, 2-pyrrolidone hydrobromide perbromide, N-bromosuccinimide, Nchlorosuccinimide or N-iodosuccinimide) in an organic solvent (for example, tetrahydrofuran, diethyl ether or 1,4-dioxane) to give a compound of Formula VI which can be reacted with a compound of Formula VII in the presence of an organic base (for example, triethylamine, pyridine, diisopropylamine or N-methylmorpholine in an organic solvent (for example, dichloromethane, dichloroethane, chloroform or carbon tetrachloride) to give a compound of Formula VIII which can be reacted with a compound of Formula -NH2OR (path a) in the presence of an organic base (for example, pyridine, triethylamine or trimethylamine) in an organic solvent (for example, ethanol, methanol, propanol or isopropanol) to give a compound of Formula X. The reduction of the compound of Formula VIII (path b) can be carried out in the presence of a reducing agent (for example, sodium borohydride, sodium cyanoborohydride or lithium aluminium hydride) in an organic solvent (for example, methanol, ethanol, propanol or isopropanol) to give a compound of Formula IX. The compound of Formula IX undergoes N-derivatization (path bl) to give a compound of Formula IXa in an organic solvent (for example, acetonitrile, dichloromethane, chloroform or carbon tetrachloride) in the presence of a base (for example, potassium carbonate, sodium carbonate or sodium bicarbonate). The compound of Formula IX undergoes (path b2) undergo deprotection in the presence of a deprotecting agent (for example, palladium on carbon in presence of hydrogen gas or palladium on carbon in ammonium formate solution) in an organic solvent (for example, methanol, ethanol, propanol or isopropyl alcohol) to a give a compound of Formula XI, which undergoes reductive amination to give a compound of Formula XIa with formaldehyde in an organic solvent (for example, acetonitrile or dichloromethane) with formaldehyde in the presence of reducing agent (for example, sodium cyanoborohydride or sodium triacetoxy borohydride).. The reductive amination of a compound of Formula VIII (path c) with formaldehyde to give a compound of Formula VIII can be carried out in an organic solvent (for example, acetonitrile or dichloromethane) with formaldehyde in the presence of reducing agent (for example, sodium cyanoborohydride or sodium triacetoxy borohydride). The compound of Formula VIII (when R.2 is ~^ ) (path d) can undergo deprotection to give a compound of Formula Vlllb in the presence of a deprotecting agent (for example, palladium on carbon in presence of hydrogen gas or palladium on carbon in ammonium formate solution) in an organic solvent (for example, methanol, ethanol, propanol or isopropyl alcohol). Particular compounds generally prepared in this manner are shown here: 3-(3-Azabicyclo[3.1.0]hex-6-ylamino)-l-cyclopentyl-l-phenyl-propane-l,2-diol (Compound No. 3) 3-(3-Azabicyclo[3.1.0]hex-6-ylamino)-l,l-diphenyl-propane-l,2-diol (Compound No. 5) 3-(3-Benzyl-3-azabicyclo[3.1.0]hex-6-ylmethyl)-methyl-amino]-1 -cyclopentyl-1 -phenyl-propane- 1,2-diol (Compound No. 6) 3 - [(3 -benzyl-3 -aza-bicyclo [3.1.0] hex-6-ylmethyl)-methyl-amino] -1 -cyclopentyl-1 -hydroxy-1 - phenyl-propan-2-one-oxime (Compound No. 8) 3-[(3-Azabicyclo[3.1.0]hex-6-ylmethyl)-methyl-amino]-l -cyclopentyl- l-phenyl-propane-l,2-diol (Compound No. 9) 1-Cyclopentyl-l-phenyl-3-(piperazin-l-yl)-propane-l,2-diol (Compound No. 10) l-Cyclopentyl-3-(4-methyl-piperazin-l-yl)-l-phenyl-propane-l,2-diol (Compound No. 11) 3-(4-Benzyl-piperazin-l-yl)-l-cyclopentyl-l-phenyl-propane-l,2-diol (CompoundNo. 12) 1-Cyclopentyl-l-phenyl-3-(piperidin-l-yl)-propane-l,2-diol (Compound No. 13) l-Cyclopentyl-l-hydroxy-l-phenyl-3-(piperidin-l-yl)-propan-2-one (Compound No. 14) l-Cyclopentyl-l-hydroxy-3-(morpholin-4-yl)-l-phenyl-propane-2-one (Compound No. 15) l-Cyclopentyl-3-(morpholin-4-yl)-l-phenyl-propane-l,2-diol (Compound No. 16) 3-(l-Benzyl-piperidin-4-ylamino)-1 -cyclopentyl-1 -hydroxy-1 -phenyl-propan-2-one (Compound No. 17) 3-(1 -Benzyl-piperidin-4-ylamino). 1 -cyclopentyl-l-phenyl-l,2-diol (Compound No. 18) 3-[(l-Benzyl-piperidin-4-yl)-methyl-amino]-l-cyclopentyl-l-hydroxy-l-phenyl-propan-2-one (Compound No. 19) 3-( 1 -Benzyl-piperidin-4-ylamino)-1 -cyclopentyl-1 -hydroxy-1 -phenyl-propan-2-one oxime (Compound No. 20) l-Cyclopentyl-3-(3,5-dimethyl-piperazin-l-yl)-l-hydroxy-1-phenyl-propan-2-one (Comp No. 21) l-Cyclopentyl-3-(3,5-dimethyl-piperazin-l-yl)-l-phenyl-propane-l,2-diol (CompoundNo. 22) 1 -Cyclopentyl-1 -hydroxy-3-[methyl-(l -methyl-piperidin-4-yl)-amino] -1-phenyl-propan-2-one (Compound No. 23) 1 -Cyclopentyl-3-[methyl-(l -methyl-piperidin-4-yl)-amino]-1 -phenyl-propane-1,2-diol (Compound No. 24) 3-[(3-Benzyl-3-aza-bicyclo[3.1.0]hex-6-yl)-methyl-amino]-l-cyclopentyl-l-hydroxy-1-phenylpropan- 2-one (Compound No. 25) 3-[(3-Benzyl-3-aza-bicyclo[3.1.0]hex-6-yl)-methyl-amino]-l -cyclopentyl-1 -phenyl-propane-1,2- diol (Compound No. 26) 3-[(3-Aza-bicyclo[3.1.0]hex-6-yl)-methyl-amino]-l-cyclopentyl-l-hydroxy-1-phenyl-propan-2-one (Compound No. 27) 3-( 1 -Benzyl-piperidin-4-ylamino)-1 -cyclopentyl-1 -hydroxy-1 -phenyl-propan-2-one (Compound No. 28) 3-(l-Benzyl-pyrrolidin-3-ylamino)-l-cyclopentyl-l-propan-l,2-diol (Compound No. 29) l,l-Diphenyl-3-piperazin-l-yl-propane-l,2-diol (Compound No. 30) 3-(4-Methyl-piperazin-l-yl)-l,l-diphenyl-propane-l,2-diol (Compound No. 31) 1 -Hydroxy-3 - [methyl-( 1 -methyl-piperidin-4-yl)-amino)-1,1 -diphenyl-propan-2-one (Compound No. 32) 3-[Methyl-(l-methyl-piperidin-4-yl)-amino]-l,l-diphenyl-propane-1,2-diol (Compound No. 33) 3-( 1 -Benzyl-pyrrolidin-3-ylamino)-1 -cyclopentyl-1 -hydroxy-1 -phenyl-propan-2-one (Compound No. 34) 3 - [(1 -Benzyl -pyrrolidin-3 -yl)-methyl-amino] -1 -cyclopentyl-1 -hydroxy-1 -phenyl-propan-2-one (Compound No. 35) 3-[4-(4-Chloro-benzyl)-piperazin-l-yl]-l-cyclopentyl-l-phenyl-propane-l,2-diol (Comp No. 36) 1-Cyclopentyl-l-hydroxy-3-(3-methyl-piperazin-l-yl)-l-phenyl-propan-2-one (Compound No. 39) l-Cyclopentyl-3-(3-methyl-piperazin-l-yl)-l-phenyl-propane-1,2-diol (Compound No. 40) l-Cyclopentyl-3-[l,4]diazepan-1-yl-l-hydroxy-l-phenyl-propan-2-one (CompoundNo. 41) l-Cyclopentyl-3-[l,4]diazepan-l-yl-l-phenyl-propane-l,2-diol (Compound No. 42) 3-[l,4']Bipiperidinyl-r-yl-l-cyclopentyl-l-hydroxy-l-phenyl-propan-2-one (Compound No. 43) 3-[l,4']Bipiperidinyl-l'-yl-l-cyclopentyl-l-phenyl-propane-l,2-diol (Compound No. 44) (2R)-1 -Cyclopentyl-3 - {[2-(dimethylamino)ethyl] amino} -1 -hydroxy-1 -phenylacetone (Compound No. 45) l-Cyclopentyl-3-[r-(3-cyclopentyl-2,3-dihydroxy-3-phenyl-propyl)-[4,4']bipiperidinyl-l-yl]-lphenyl- propane-l,2-diol (CompoundNo. 46) 3-(l-Benzyl-pyrrolidin-3-ylamino)-l,l-diphenyl-propane-l,2-diol (Compound No. 47) 3-[4-(2-Benzo[l,3]dioxol-5-yl-ethyl)-[l,4]diazepan-l-yl]-l-cyclopentyl-l-phenyl-propane-l,2-diol (Compound No. 51) l-Cyclopentyl-3-dimethylamino-l -hydroxy-l-phenyl-propan-2-one (Compound No. 53) l-Cyclopentyl-3-dimethylamino-l-phenyl-propane-l,2-diol (CompoundNo. 54) 3-[l,4]Diazepan-l-yl-l-hydroxy-l,l-diphenyl-propan-2-one (CompoundNo. 55) 3-[l,4]Diazepan-l-yl-l,l-diphenyl-propane-l,2-diol (CompoundNo. 56) 3-[4-(2-Benzo[l,3]dioxol-5-yl-ethyl)-[l,4]diazepan-l-yl]-l-hydroxy-l,l-diphenyl-propan-2-one (Compound No. 57) 3-[4-(2-Benzo[l,3]dioxol-5-yl-ethyl)-[l,4]diazepan-l-yl]-l,l-diphenyl-propane-l,2-diol (Compound No. 58) 1 -Cyclopentyl-3-(4-hydroxy-piperidin-l-yl)-l-phenyl-propane-l,2-diol (CompoundNo. 59) l-Cyclopentyl-3-(2-dimethylamino-ethylamino)-l-phenyl-propane-l,2-diol (Compound No. 60) l-Cyclopentyl-l-hydroxy-3-(4-methyl-[l,4]diazepan-l-yl)-l-phenyl-propan-2-one (Comp No. 61) l-Cyclopentyl-3-(4-methyl-[l,4]diazepan-l-yl)-l-phenyl-propane-l,2-diol (Compound No. 62) l-[l,4]Diazepan-l-yl-3-hydroxy-4-methyl-3-phenyl-pentan-2-one (Compound No. 63) l-[l,4]Diazepan-l-yl-4-methyl-3-phenyl-pentane-2,3-diol (CompoundNo. 64) l-Cyclopentyl-l-hydroxy-3-imidazol-l-yl-l-phenyl-propan-2-one (Compound No. 65) 1-Cyclopentyl-3-imidazol-1-yl-l-phenyl-propane-1,2-diol (Compound No. 66) l-Cyclopentyl-l-hydroxy-3-(2-methyl-imidazol-1-yl)-l-phenyl-propan-2-one (Compound No. 67) l-Cyclopentyl-3-(2-methyl-imidazol-l-yl)-l-phenyl-propane-1,2-diol (Compound No. 68) l-Cyclopentyl-l-hydroxy-3-(2-isopropyl-imidazol-l-yl)-l-phenyl-propan-2-one (CompNo. 69) 1 -Cyclopentyl-3-(2-isopropyl-imidazol-l-yl)-l-phenyl-propane- 1,2-diol (Compound No. 70) l-Cyclopentyl-l-hydroxy-3-(2-methyl-4,5-dihydro-imidazol-l-yl)-l-phenyl-propan-2-one (Compound No. 71) 1-Cyclopentyl-l-hydroxy-l-phenyl-3-pyrrolidin-l-yl-propan-2-one (Compound No. 72) l-Cyclopentyl-l-phenyl-3-pyrrolidin-l-yl-propane-1,2-diol (Compound No. 73) 3-Azepan-l-yl-l-cyclopentyl-l-hydroxy-l-phenyl-propan-2-one (Compound No. 74) 3-Azepan-l-yl-l-cyclopentyl-l-phenyl-propane- 1,2-diol (Compound No. 75) l-Cyclopentyl-l-hydroxy-3-(3-hydroxy-piperidin-l-yl)-l-phenyl-propan-2-one (Comp No. 76) l-Cyclopentyl-3-(3-hydroxy-piperidin-l-yl)-l-phenyl-propane-l,2-diol (Compound No. 77) 3-(4-Benzyl-piperidin-l-yl)-l-cyclopentyl-l-hydroxy-l-phenyl-propan-2-one (Compound No. 78) 1 -Cyclopentyl-3-(2-dimethylamino-ethylamino)-l-phenyl-propane- 1,2-diol (Compound No. 80) (2R)-l-Cyclopentyl-l-hydroxy-3-(2-methyl-imidazol-l-yl)-l-phenyl-propan-2-one (Comp No. 81) 5-(3-Cyclopentyl-3-hydroxy-2-oxo-3-phenyl-propyl)-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (Compound No. 82) Methanesulfonic acid 3-(3-cyclopentyl-3-hydroxy-2-oxo-3-phenyl-propyl)-3-aza-bicyclo[3.2.1]oct- 8-yl ester (Compound No. 83) Methanesulfonic acid 3-(3-cyclopentyl-3-hydroxy-2-oxo-3-phenyl-propyl)-3-aza-bicyclo[3.2.1]oct- 8-yl ester (Compound No. 84) (2R)-l-Cyclopentyl-l-hydroxy-3-(2-methyl-4,5-dihydro-imidazol-l-yl)-l-phenyl-propan-2-one (Compound No. 85) (Figure Removed) The compounds of Formula XI may also be prepared, (for example, by the reaction sequence as shown in Scheme II. The preparation comprises hydrogenating a compound of Formula III (where X is the same as defined earlier except alkyne) to give a compound of Formula XII, which can be oxidized to give a compound of Formula XIII, which can be reacted with a compound of Formula VII to give a compound of Formula IX (wherein RI and RI are the same as undefined earlier), which can be deprotected (when R2 is N—/ wherein P is the same as defined earlier) to give a compound of Formula XI. Hydrogenation of a compound of Formula III can be carried out in the presence of a reducing agent (for example, palladium on calcium carbonate or sodium in liquid ammonia solution) in a hydrocarbon (for example, toluene, heptane, xylene or benzene) to give a compound of Formula XII which can be oxidized in the presence of an oxidising agent (for example, mchloroperbenzoic acid, perbenzoic acid or peracetic acid) in an organic solvent (for example, dichloromethane, dichloroethane, carbon tetrachloride or chloroform) to give a compound of Formula XIII which can be reacted with a compound of Formula VII in the presence of an organic base (for example, triethylamine, pyridine, N-methylmorpholine or diisopropylethylamine) in an organic solvent (for example, dichloromethane, dichloroethane, carbon tetrachloride or chloroform) to give a compound of Formula IX which can be deprotected in the presence of a deprotecting agent (for example, palladium on carbon in hydrogen gas or palladium on carbon in ammonium formate solution in an organic solvent (for example, methanol, ethyl acetate, ethanol or isopropanol) to give compound of Formula XI. Particular exemplary compounds prepared according to the procedure described are shown here: (R or S) 3-(3-Benzyl-3-azabicyclo[3.1.0]hex-6-ylamino)-l-cyclopentyl-l-phenyl-propane-l,2-diol (Compound No. 1) (R or S) 3-(3-Benzyl-3-azabicyclo[3.1.0]hex-6-ylamino)-l,l-diphenyl-propane-l,2-diol (Compound No. 2) (Ror S) 3-[(3-Benzyl-3-azabicyclo[3.1.0]hex-6-ylmethyl-amino)]-l-cyclopentyl-l-phenyl-propane- 1,2-diol (Compound No. 4) (R or S) 3-(3-Benzyl-3-azabicyclo[3.1.0]hex-6-ylamino)-l-cyclopentyl-l-phenyl-propane-l,2-diol (Compound No. 7) The compounds of Formula XI may be prepared, for example, by the reaction sequence as shown in Scheme III. The preparation comprises reacting a compound of Formula II (wherein X is the same as defined earlier) with vinyl magnesium bromide to give a compound of Formula XII, which can be oxidized to give a compound of Formula XIII, which can be reacted with a compound of Formula VII to give a compound of Formula IX (wherein RI and R2 are the same as defined earlier), which can be deprotected (when RI is give a compound of Formula XI. wherein P is the same as defined earlier) to (Figure Removed) The reaction of a compound of Formula II with vinyl magnesium bromide can be carried out in an organic solvent (for example, tetrahydrofuran, diethyl ether or dioxane) to give a compound of Formula XII which can undergo oxidation in the presence of an oxidizing agent (for example, m-chloroperbenzoic acid, perbenzoic acid or peracetic acid) in an organic solvent (for example, dichloromethane, dichloroethane, carbon tetrachloride or chloroform) to give a compound of Formula XIII which on reaction with a compound of Formula VII in the presence of an organic base (for example, triethylamine, pyridine, N-methylmorpholine or di-isopropyl ethylamine in an organic solvent (for example, dichloromethane, dichloroethane, carbon tetrachloride or chloroform) can give a compound of Formula IX which can undergo deprotection in the presence of a deprotecting agent (for example, palladium on carbon or palladium on carbon) in ammonium formate solution in an organic solvent (for example, methanol, ethyl acetate, ethanol or isopropanol) to give a compound of Formula XI. The compounds of Formula XVIII may be prepared, for example, by the reaction sequence as shown in Scheme IV. The preparation comprises reacting a compound of Formula IX (wherein X is the same as defined earlier) with a compound of Formula Rs-hal (wherein RS is mesyl, tosyl or 4-nitrobenzenesulphonyl group and hal is the same as defined earlier) to give of Formula XIV, which can be treated with sodium azide to give a compound of Formula XV, which can be further reduced to give a compound of Formula XVI, which is reacted with a compound of Formula XVII to give a compound of Formula XVIII (wherein R' and Y the same as defined earlier). The compound of Formula IX can be reacted with a compound of Formula Rs-hal in the presence of an organic base (for example, triethyl amine or trimethyl amine) in an organic solvent (for example, dichloromethane, chloroform or carbon tetrachloride) to give a compound of Formula XIV which can be reacted with sodium azide in an organic solvent (for example, dimethylformamide or dimethylsulphoxide) to give a compound of Formula XV which can be reduced with a suitable reducing agent (for example, triphenylphosphine or lithium aluminum hydride) in an organic solvent (for example, tetrahydrofuran or 1,4-dioxane) to give a compound of Formula XVI which can be reacted with a compound of Formula XVII in the presence of an organic base (for example, triethylamine or pyridine) in an organic solvent (for example, dichloromethane, carbon tetrachloride or ethyl acetate) to give a compound of Formula XVIII. Scheme V X FormulaXX FormuteXXI The compounds of Formulae XX and XXI may be prepared, for example, by the reaction sequence as shown in Scheme V. The preparation comprises N-derivatizing a compound of Formula XIX to give a compound of Formula XX, which undergoes reduction to give a compound of Formula XXI. The N-derivatization of a compound of Formula XIX to give a compound of Formula XX can be carried out in an organic solvent (for example, acetonitrile, dichloromethane, chloroform or carbon tetrachloride) in the presence of a base (for example, potassium carbonate, sodium carbonate or sodium bicarbonate). The reduction of a compound of Formula XX to give a compound of Formula XXI can be carried out in the presence of a reducing agent (for example, sodium borohydride, sodium cyanoborohydride or lithium aluminium hydride) in an organic solvent (for example, methanol, ethanol, propanol or isopropanol). Particular exemplary compounds prepared according to the procedure described are shown here: 3-[4-(2-Benzo[l,3]dioxol-5-yl-ethyl)-piperazin-l-yl]-l-cyclopentyl-l-phenyl-propane-l,2-diol (Compound No. 37) 3 - [4-(2-Benzo [1,3] dioxol-5 -yl-ethyl)-piperazin-1 -yl] -1 -cyclopentyl-1 -phenyl-propane-1,2-diol (Compound No. 38) 1 -Cyclopentyl-3-[4-(3-methyl-but-2-enyl)-piperazin-1 -yl]-1 -phenyl-propane-1,2-diol (Compound No. 48) 3 - [4-(2-Benzo[ 1,3] dioxol-5 -yl-ethyl)- [ 1,4] diazepan-1 -yl] -1 -cyclopentyl-1 -hydroxy-1 -phenylpropan- 2-one (Compound No. 49) 1 -Cyclopentyl-3 - {4- [2-(2,3 -dihydro-benzofuran-5-yl)-ethyl] -[1,4] diazepan-1 -yl} -1 -hydroxy-1 - phenyl-propan-2-one (Compound No. 50) 1 -Cyclopentyl-3 - {4- [2-(2,3 -dihydro-benzofuran-5 -yl)-ethyl] - [ 1,4] diazepan-1 -y 1} -1 -phenylpropane- 1,2-diol (Compound No. 52) 3 - [4-(2-Benzo [1,3] dioxol-5-yl-ethyl)- [ 1,4]diazepan-1 -yl] -1 -cyclopentyl-1 -phenyl-propane-1,2-diol (Compound No. 79) In the above scheme, where specific bases, condensing agents, protecting groups, deprotecting agents, solvents, catalysts, temperatures, etc. are mentioned, it is to be understood that other bases, condensing agents, protecting groups, deprotecting agents, solvents, catalysts, temperatures, etc. known to those skilled in the art may be used. Similarly, the reaction temperature and duration may be adjusted according to the desired needs. Suitable salts of the compounds represented by the Formula I were prepared so as to solubilize the compound in aqueous medium for biological evaluations, as well as to be compatible with various dosage formulations and also to aid in the bioavailability of the compounds. Examples of such salts include pharmacologically acceptable salts such as inorganic acid salts (for example, hydrochloride, hydrobromide, sulphate, nitrate and phosphate), organic acid salts (for example, acetate, tartarate, citrate, fumarate, maleate, tolounesulphonate and methanesulphonate). When carboxyl groups are included in the Formula I as substituents, they may be present in the form of an alkaline or alkali metal salt (for example, sodium, potassium, calcium, magnesium, and the like). These salts may be prepared by various techniques, such as treating the compound with an equivalent amount of inorganic or organic, acid or base in a suitable solvent. Because of their valuable pharmacological properties, the compounds described herein may be administered to an animal for treatment orally, or by a parenteral route. The pharmaceutical compositions described herein can be produced and administered in dosage units, each unit containing a certain amount of at least one compound described herein and/or at least one physiologically acceptable addition salt thereof. The dosage may be varied over extremely wide limits, as the compounds are effective at low dosage levels and relatively free of toxicity. The compounds may be administered in the low micromolar concentration, which is therapeutically effective, and the dosage may be increased as desired up to the maximum dosage tolerated by the patient. The compounds described herein can be produced and formulated as their enantiomers, diastereomers, N-Oxides, polymorphs, solvates and pharmaceutically acceptable salts, as well as metabolites having the same type of activity. Pharmaceutical compositions comprising the molecules of Formula I or metabolites, enantiomers, diastereomers, N-oxides, polymorphs, solvates or pharmaceutically acceptable salts thereof, in combination with pharmaceutically acceptable carrier and optionally included excipient can also be produced. The examples mentioned below demonstrate general synthetic procedures, as well as specific preparations of particular compounds. The examples are provided to illustrate the details of the invention and do not limit the scope of the present invention. Examples Various solvents, such as acetone, methanol, pyridine, ether, tetrahydrofuran, hexanes, and dichloromethane, were dried using various drying reagents according to procedures described in the literature. IR spectra were recorded as Nujol mulls or a thin neat film on a Perkin Elmer Paragon instrument. Nuclear Magnetic Resonance (NMR) spectra were recorded on a Varian XL-300 MHz instrument using tetramethylsilane as an internal standard. Example 1: Preparation of 1 -cvclopentyl-1 -hydroxy-1 -phenvl propvne A solution of n-butyl lithium (15%, 54.0 mL, 92.0 mM) in dry tetrahydrofuran (200.0 mL) was saturated with dry acetylene gas at -78°C. To the reaction mixture thus obtained was added phenyl cyclopentyl ketone (8.0 g, 46.0 mM) in dry tetrahydrofuran (50.0 mL) dropwise at the same temperature under stirring. The reaction mixture was brought to 25-30°C under stirring and saturated ammonium chloride solution (30.0 mL) was added, followed by stirring for 5 minutes. The organic layer was separated and washed with saturated brine solution (30.0 mL). Tetrahydrofuran was distilled off under reduced pressure and the residue was purified through column chromatography using 10% ethyl acetate in hexane solvent mixture as an eluent to get the title organic compound. Yield: 87% (8.0 g); IR (DCM): 3422.8, 3299.9, 2110.9 cm'1; [H NMR (CDC13):5 7.65-7.67 (m, 2H), 7.28-7.39 (m, 3H), 2.68 (s, 1H), s, 1H), 2.38-2.43 (m, 1H), 1.57-1.78 (m, 5H), 1.40-1.50 (m, 3H). Example 2: Preparation of 1 -cyclopentvl-1 -acetoxy-1 -phenvl-2-propanone To a solution of 1 -cyclopentyl-1 -hydroxy-1-phenyl-2-propyne (3.0 g, 15 mM) in glacial acetic acid (21.0 mL) was added acetic anhydride (2.1 mL) followed by addition of mercuric acetate (5.3 g, 16.5 mM) portionwise. The reaction mixture was stirred for 72 hours at 25-30°C followed by addition of thioacetamide (1.2 g, 16.5 mM). Stirring was continued for three hours at the same temperature. The reaction mixture was diluted with ether (150.0 mL). The reaction mixture was filtered through celite pad. The filtrate was washed with water, saturated sodium bicarbonate solution, dried over anhydrous sodium sulphate and concentrated under reduced pressure to furnish title organic compound. Yield: 82% (3.2 g); IR (DCM): 1743.1, 1720.4 cm'1; *H NMR (CDC13):8 7.27-7.38 (m, 5H), 2.94- 3.04 (m, 1H), 2.27 (s, 3H), 1.92 (s, 3H), 1.27-1.70 (m, 8H). Example 3: Preparation of 1 -cyclopentyl-1 -hydroxy-1 -phenyl-2-propanone To a solution of 1-cyclopentyl-1-acetoxy-l-phenyl-2-propanone (4.0 g, 15.4 mM) in methanol (20.0 mL), aqueous potassium hydroxide solution (1.3 g, 23.0 mM, 1.5 mL of water) was added and the reaction mixture was refluxed for 2 hours. Cooled the reaction mixture to room temperature and methanol was removed under reduced pressure. The residue thus obtained was diluted with water (10.0 mL) and extracted with ethyl acetate (3x25.0 mL). The ethyl acetate layer was washed with water and brine solution. Dried over anhydrous sodium sulphate and concentrated under reduced pressure to get the title organic compound. Yield: 90% (3.2 g); IR (DCM): 3456.6, 1704.5 cm"1; 'H NMR (CDC13):8 7.52-7.54 (m, 2H), 7.27- 7.38 (m, 3H), 4.61 (s, 1H, OH), 3.02-3.07 (m, 1H), 2.11 (s, 3H), 1.26-1.72 (m, 8H). Example 4: Preparation of 3 -bromo-1 -cyclopentyl-1 -hydroxy-1 -phenyl-2-propanone To a solution of 1-cyclopentyl-1-hydroxy-1-phenyl-2-propanone (3.4 g, 15.6 mM) in dry tetrahydrofuran (150.0 mL), tetrahydrofuran solution of pyridine hydrobromide perbromide (6.0 g, 18.7 mM, 85% pure, 100.0 mL of dry tetrahydrofuran) was added dropwise at room temperature and the stirring was continued for 36 hour at the same temperature. The solid so separated was filtered and the filtrate was concentrated under reduced pressure. The residue was purified through column chromatography using 2% ethyl acetate in hexane as an eluent to get the title organic compound. Yield: 64% (3.0 g); IR (DCM): 1721.5 cm'1; 'HNMR (CDC13):5 7.50-7.53 (m, 2H), 7.28-7.40 (m, 3H), 4.05-4.2 (m, 2H), 3.80 (s, 1H, -OH), 3.02-3.08 (m, 1H), 1.28-1.43 (m, 8H). Example 5: Preparation of 1 -cvclopentyl-1 -hydroxv-1 -phenyl-2-propene To a solution of 1 -cyclopentyl-1 -hydroxy-1-phenyl-2-propyne (5.0 g, 24.8 mM) in toluene (50.0 mL), palladium on calcium carbonate (0.5 g) was added and the reaction mixture was subjected to hydrogenation at room temperature under atmospheric pressure. The reaction mixture was filtered and the residue thus obtained was purified through column chromatography using 2% ethyl acetate in hexane as an eluent to get the title organic compound. IR (DCM): 3479.9 cm"1; *HNMR (CDC13):8 7.19-7.47 (m, 5H), 6.21-6.31 (m, 1H), 5.12-5.31 (m, 2H), 2.47-2.58 (m, 1H), 1.36-1.57 (m, 8H). Example 6: Preparation of 1 -cvclopentyl-l-hvdroxv-l-phenvl-2,3-epoxy propane To a solution of l-cyclopentyl-l-hydroxy-l-phenyl-2-propene (0.95 g, 4.7 mM) in dry dichloromethane (10.0 mL) at 0-5°C, dichloromethane solution of m-chloroperbenzoic acid (2.03 g, 5.9 mM, 15.0 mL dichloromethane) was added dropwise. The reaction mixture was stirred at room temperature for 12 hour and triethylamine (3.0 mL) was added to the reaction mixture and stirred for 15 minutes. The reaction mixture was poured onto saturated sodium bicarbonate solution (10.0 mL) and dichloromethane layer was separated, washed with saturated sodium bicarbonate solution (10.0 mL), water (10.0 mL) and brine solution. Dried over anhydrous sodium sulphate and concentrated under reduced pressure. The residue was purified by column chromatography using 5% ethyl acetate in hexane to get non-polar epoxide-A (0.28 g) and polar epoxide-B (0.5 g). Non polar epoxide-A: IR (KBr): 3477.5 cm'1; !H NMR (CDC13):6 7.18-7.46 (m, 5H), 3.36-3.38 (m, 1H), 2.57-2.63 (m, 2H), 1.32-1.67 (m, 9H). Polar epoxide-B: IR (KBr): 3390.7 cm'1; 'H NMR (CDC13):S 7.24-7.50 (m, 5H), 3.48-3.50 (m, 1H), 2.97-2.99 (m, 1H), 2.83-2.86 (m, 1H), 2.50 (m, 1H), 1.33-1.71 (m, 8H). Example 7: Preparation of 1.1 -diphenyl-1 -hvdroxv-2-propvne. The title compound was prepared by using benzophenone in place of phenyl cyclopentyl ketone following the procedure mentioned for the synthesis of 1-cyclopentyl-1-hydroxy-l-phenyl- 2-propyne. IR (DCM): 3540.0, 3438.4 cm'1; !H NMR (CDC13):8 7.59-7.62 (m, 4H), 7.27-7.36 (m, 6H), 2.89 (s, 1H), 2.86 (s, 1H). Example 8: Preparation of 1 .l-diphenvl-l-hvdroxy-2-propene The title compound was prepared by using corresponding acetylenic compound following the procedure mentioned for the synthesis of 1-cyclopentyl-l-hydroxy-l-phenyl-2-propene. Yield: 90%; IR (DCM): 3449.4 cm'1; 'H NMR (CDC13):5 7.24-7.43 (m, 10H), 6.47-6.56 (m, 1H), 5.30-5.35 (m, 2H). Example 9: Preparation of l.l-diphenvl-l-hvdroxy-2.3-epoxv-propane The title compound was a prepared starting from the corresponding olefin following the procedure mentioned for the synthesis of 1-cyclopentyl-l-hydroxy-l-phenyl-2,3-epoxy propane. Polar epoxide B: Yield: 69%; IR (KBr): 3382.9 cm'1; !H NMR (CDC13):8 7.48-7.50 (m, 2H), 7.24- 7.38 (m, 8H), 3.78-3.80 (m, 1H), 2.97-2.99 (m, 1H), 2.77-2.80 (m, 1H), 2.55 (s, 1H). Example 10: Preparation of (la. 5a. 6a)-6-methvlamino-methyl-3-benzyl-3- azabicvclo[3.1 .OJhexane Step a: Preparation of (la, 5a, 6

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# Name Date
1 1979-delnp-2007-abstract.pdf 2011-08-21
1 1979-delnp-2007-form-2.pdf 2011-08-21
2 1979-delnp-2007-claims.pdf 2011-08-21
2 1979-delnp-2007-form-1.pdf 2011-08-21
3 1979-delnp-2007-correspondence-others.pdf 2011-08-21
3 1979-delnp-2007-description(complete).pdf 2011-08-21
4 1979-delnp-2007-correspondence-others.pdf 2011-08-21
4 1979-delnp-2007-description(complete).pdf 2011-08-21
5 1979-delnp-2007-claims.pdf 2011-08-21
5 1979-delnp-2007-form-1.pdf 2011-08-21
6 1979-delnp-2007-abstract.pdf 2011-08-21
6 1979-delnp-2007-form-2.pdf 2011-08-21